SIMILAR PATTERNS OF AMINO ACIDS FOR 1XKK_A_FMMA91_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k2p TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 428
MET A 449
THR A 474
GLY A 480
CYH A 481
ASP A 539
PHE A 540
 None
 1.03A 1xkkA-1k2pA:
29.5		 1xkkA-1k2pA:
31.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k2p TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 428
THR A 474
GLY A 480
CYH A 481
LEU A 483
ARG A 487
LEU A 528
ASP A 539
PHE A 540
 None
 0.91A 1xkkA-1k2pA:
29.5		 1xkkA-1k2pA:
31.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 ALA A 220
THR A 266
GLY A 272
ASP A 276
ARG A 279
LEU A 321
 None
 0.59A 1xkkA-1k9aA:
25.7		 1xkkA-1k9aA:
26.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 THR A 266
GLY A 272
ASP A 276
ARG A 279
LEU A 321
ASP A 332
 None
 0.57A 1xkkA-1k9aA:
25.7		 1xkkA-1k9aA:
26.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 THR A 334
GLY A 340
LEU A 343
ASP A 344
ARG A 347
LEU A 389
 P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
None
None
None
P16  A   2 (-4.4A)
 0.75A 1xkkA-1opkA:
29.2		 1xkkA-1opkA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  99
GLY A 153
LEU A 201
ASP A 212
PHE A 213
 ATP  A 535 (-3.6A)
ATP  A 535 ( 4.7A)
ATP  A 535 (-4.8A)
MG  A 536 (-3.3A)
5EA  A1001 (-3.6A)
 0.51A 1xkkA-1s9iA:
24.7		 1xkkA-1s9iA:
25.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 389
GLY A 441
CYH A 442
ASP A 445
LEU A 489
PHE A 501
 None
 0.45A 1xkkA-1snxA:
22.7		 1xkkA-1snxA:
31.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 389
MET A 410
ASP A 445
LEU A 489
ASP A 500
PHE A 501
 None
 0.86A 1xkkA-1snxA:
22.7		 1xkkA-1snxA:
31.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 389
MET A 410
GLY A 441
ASP A 445
LEU A 489
PHE A 501
 None
 0.77A 1xkkA-1snxA:
22.7		 1xkkA-1snxA:
31.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 MET A 410
ASP A 445
ARG A 448
LEU A 489
ASP A 500
PHE A 501
 None
 1.12A 1xkkA-1snxA:
22.7		 1xkkA-1snxA:
31.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 MET A 410
GLY A 441
ASP A 445
ARG A 448
LEU A 489
PHE A 501
 None
 1.07A 1xkkA-1snxA:
22.7		 1xkkA-1snxA:
31.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 621
THR A 670
GLY A 676
LEU A 679
ARG A 683
LEU A 799
 STI  A   3 (-3.5A)
STI  A   3 (-3.2A)
STI  A   3 ( 3.8A)
None
None
STI  A   3 (-4.4A)
 0.63A 1xkkA-1t46A:
24.4		 1xkkA-1t46A:
31.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA X  37
THR X  82
GLY X  88
LEU X  91
ASP X  92
LEU X 137
PHE X 149
 STU  X 902 (-3.1A)
STU  X 902 (-4.1A)
STU  X 902 (-3.5A)
None
None
STU  X 902 (-4.4A)
None
 0.89A 1xkkA-2dq7X:
24.9		 1xkkA-2dq7X:
32.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 THR X  82
GLY X  88
LEU X  91
ASP X  92
LEU X 137
ASP X 148
PHE X 149
 STU  X 902 (-4.1A)
STU  X 902 (-3.5A)
None
None
STU  X 902 (-4.4A)
STU  X 902 (-3.6A)
None
 0.91A 1xkkA-2dq7X:
24.9		 1xkkA-2dq7X:
32.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		9 ALA A 293
MET A 314
THR A 338
GLY A 344
LEU A 347
ASP A 348
LEU A 393
ASP A 404
PHE A 405
 H8H  A 534 (-3.2A)
None
H8H  A 534 (-3.1A)
H8H  A 534 (-3.3A)
None
None
H8H  A 534 (-4.5A)
H8H  A 534 (-4.2A)
None
 0.89A 1xkkA-2h8hA:
33.3		 1xkkA-2h8hA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 ALA A 293
THR A 338
GLY A 344
LEU A 347
ASP A 348
LEU A 393
ASP A 404
 QUE  A   1 (-3.5A)
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
None
QUE  A   1 ( 4.1A)
QUE  A   1 (-4.4A)
None
 0.76A 1xkkA-2hckA:
31.3		 1xkkA-2hckA:
27.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 MET A 314
THR A 338
GLY A 344
LEU A 347
ASP A 348
ASP A 404
 None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
None
QUE  A   1 ( 4.1A)
None
 0.97A 1xkkA-2hckA:
31.3		 1xkkA-2hckA:
27.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 271
THR A 316
GLY A 322
LEU A 325
ASP A 326
LEU A 371
 1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
None
None
1BM  A 499 (-4.4A)
 0.66A 1xkkA-2hk5A:
25.3		 1xkkA-2hk5A:
32.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 THR A 316
GLY A 322
LEU A 325
ASP A 326
LEU A 371
ASP A 382
 1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
None
None
1BM  A 499 (-4.4A)
1BM  A 499 (-4.4A)
 0.76A 1xkkA-2hk5A:
25.3		 1xkkA-2hk5A:
32.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 269
THR A 315
GLY A 321
LEU A 324
ASP A 325
ARG A 328
LEU A 370
 GIN  A 600 (-3.1A)
GIN  A 600 (-3.4A)
None
None
None
None
GIN  A 600 (-4.7A)
 0.54A 1xkkA-2hz0A:
29.8		 1xkkA-2hz0A:
34.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 271
THR A 316
GLY A 322
ASP A 326
LEU A 371
 1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.5A)
None
1N8  A 501 ( 4.3A)
 0.48A 1xkkA-2og8A:
24.9		 1xkkA-2og8A:
33.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 MET A 637
GLY A 669
LEU A 672
ARG A 676
LEU A 785
ASP A 796
 None
 1.37A 1xkkA-2ogvA:
27.0		 1xkkA-2ogvA:
32.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 THR A 663
GLY A 669
LEU A 672
ARG A 676
LEU A 785
ASP A 796
 None
 0.92A 1xkkA-2ogvA:
27.0		 1xkkA-2ogvA:
32.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		6 ALA A  46
GLY A 109
ASP A 113
LEU A 156
THR A 166
PHE A 168
 ATP  A 381 (-3.5A)
None
None
ATP  A 381 ( 4.8A)
ATP  A 381 ( 4.6A)
None
 0.87A 1xkkA-2phkA:
21.9		 1xkkA-2phkA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		6 GLY A 109
ASP A 113
LEU A 156
THR A 166
ASP A 167
PHE A 168
 None
None
ATP  A 381 ( 4.8A)
ATP  A 381 ( 4.6A)
MN  A 382 (-2.0A)
None
 1.02A 1xkkA-2phkA:
21.9		 1xkkA-2phkA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 215
THR A 265
GLY A 271
ASP A 275
LEU A 328
ASP A 339
 ADE  A 488 (-3.2A)
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
None
ADE  A 488 (-4.4A)
None
 0.52A 1xkkA-2qluA:
24.9		 1xkkA-2qluA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 215
THR A 265
GLY A 271
LEU A 328
ASP A 339
PHE A 340
 ADE  A 488 (-3.2A)
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
None
None
 0.87A 1xkkA-2qluA:
24.9		 1xkkA-2qluA:
25.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 749
MET A 772
THR A 796
GLY A 802
LEU A 805
LEU A 850
THR A 860
ASP A 861
PHE A 862
 GW7  A   1 (-3.3A)
GW7  A   1 ( 3.8A)
GW7  A   1 (-4.0A)
GW7  A   1 (-3.6A)
None
GW7  A   1 (-4.2A)
GW7  A   1 (-3.5A)
GW7  A   1 (-4.1A)
GW7  A   1 (-3.8A)
 0.47A 1xkkA-2r4bA:
39.6		 1xkkA-2r4bA:
76.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  51
GLY A 113
ASP A 117
LEU A 160
ASP A 171
PHE A 172
 B49  A1294 (-3.2A)
B49  A1294 (-3.6A)
None
B49  A1294 (-4.4A)
B49  A1294 (-4.2A)
None
 0.96A 1xkkA-2y7jA:
22.4		 1xkkA-2y7jA:
25.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 ALA A 273
THR A 319
GLY A 325
LEU A 328
ASP A 329
LEU A 374
 None
 0.82A 1xkkA-2zv7A:
24.7		 1xkkA-2zv7A:
31.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 THR A 319
GLY A 325
LEU A 328
ASP A 329
LEU A 374
ASP A 385
 None
 0.85A 1xkkA-2zv7A:
24.7		 1xkkA-2zv7A:
31.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 220
THR A 266
GLY A 272
ASP A 276
ARG A 279
LEU A 321
 None
 0.59A 1xkkA-3d7uA:
25.6		 1xkkA-3d7uA:
32.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 THR A 266
GLY A 272
ASP A 276
ARG A 279
LEU A 321
ASP A 332
 None
 0.57A 1xkkA-3d7uA:
25.6		 1xkkA-3d7uA:
32.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 169
GLY A 226
LEU A 275
THR A 293
PHE A 295
 VIN  A6331 (-3.4A)
VIN  A6331 (-3.4A)
VIN  A6331 (-4.5A)
VIN  A6331 (-3.6A)
None
 0.48A 1xkkA-3dtcA:
28.7		 1xkkA-3dtcA:
30.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6u SERINE/THREONINE-PRO
TEIN KINASE CHK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00498
(FHA) 		7 ALA A 247
GLY A 307
ASP A 311
LEU A 354
THR A 367
ASP A 368
PHE A 369
 None
 0.78A 1xkkA-3i6uA:
22.5		 1xkkA-3i6uA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		6 ALA A  80
MET A 104
GLY A 135
ASP A 139
LEU A 182
PHE A 194
 None
 1.14A 1xkkA-3iecA:
21.7		 1xkkA-3iecA:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		6 MET A 104
GLY A 135
ASP A 139
LEU A 182
ASP A 193
PHE A 194
 None
 1.23A 1xkkA-3iecA:
21.7		 1xkkA-3iecA:
25.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kex RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 THR A 768
GLY A 774
LEU A 777
ASP A 778
ARG A 781
LEU A 822
ASP A 833
PHE A 834
 ANP  A   1 ( 4.8A)
ANP  A   1 ( 4.9A)
None
None
None
ANP  A   1 (-4.7A)
MG  A1001 ( 3.1A)
None
 0.56A 1xkkA-3kexA:
36.0		 1xkkA-3kexA:
51.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 ALA A 665
THR A 713
GLY A 719
ARG A 726
LEU A 767
ASP A 778
 None
None
GOL  A 403 (-3.4A)
None
None
None
 0.81A 1xkkA-3kulA:
31.1		 1xkkA-3kulA:
34.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		12 ALA A 719
MET A 742
THR A 766
GLY A 772
CYH A 773
LEU A 775
ASP A 776
ARG A 779
LEU A 820
THR A 830
ASP A 831
PHE A 832
 ITI  A   1 (-2.9A)
ITI  A   1 (-3.4A)
ITI  A   1 (-3.8A)
ITI  A   1 (-3.5A)
ITI  A   1 (-4.8A)
None
None
None
ITI  A   1 (-4.6A)
ITI  A   1 (-3.8A)
ITI  A   1 ( 4.6A)
ITI  A   1 (-3.6A)
 0.75A 1xkkA-3lzbA:
38.3		 1xkkA-3lzbA:
87.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 109
GLY A 165
LEU A 168
ARG A 172
LEU A 212
THR A 222
 JOZ  A 361 (-3.4A)
None
None
None
None
JOZ  A 361 (-3.7A)
 0.70A 1xkkA-3nuuA:
22.3		 1xkkA-3nuuA:
28.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 109
GLY A 165
LEU A 168
LEU A 212
THR A 222
PHE A 224
 JOZ  A 361 (-3.4A)
None
None
None
JOZ  A 361 (-3.7A)
None
 0.96A 1xkkA-3nuuA:
22.3		 1xkkA-3nuuA:
28.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A 165
LEU A 168
ARG A 172
LEU A 212
THR A 222
ASP A 223
 None
None
None
None
JOZ  A 361 (-3.7A)
SO4  A   5 ( 4.5A)
 0.80A 1xkkA-3nuuA:
22.3		 1xkkA-3nuuA:
28.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A 165
LEU A 168
LEU A 212
THR A 222
ASP A 223
PHE A 224
 None
None
None
JOZ  A 361 (-3.7A)
SO4  A   5 ( 4.5A)
None
 1.04A 1xkkA-3nuuA:
22.3		 1xkkA-3nuuA:
28.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 ALA A 751
MET A 774
THR A 798
GLY A 804
CYH A 805
LEU A 807
ASP A 808
ARG A 811
LEU A 852
THR A 862
 03Q  A   1 (-3.1A)
03Q  A   1 (-4.5A)
03Q  A   1 (-4.1A)
03Q  A   1 ( 3.9A)
None
None
None
None
03Q  A   1 (-4.4A)
03Q  A   1 (-3.3A)
 1.13A 1xkkA-3pp0A:
29.5		 1xkkA-3pp0A:
73.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 ALA A 751
THR A 798
GLY A 804
CYH A 805
LEU A 807
ASP A 808
ARG A 811
LEU A 852
THR A 862
ASP A 863
 03Q  A   1 (-3.1A)
03Q  A   1 (-4.1A)
03Q  A   1 ( 3.9A)
None
None
None
None
03Q  A   1 (-4.4A)
03Q  A   1 (-3.3A)
03Q  A   1 (-4.0A)
 0.46A 1xkkA-3pp0A:
29.5		 1xkkA-3pp0A:
73.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 751
THR A 798
GLY A 804
LEU A 852
THR A 862
ASP A 863
PHE A 864
 03Q  A   1 (-3.1A)
03Q  A   1 (-4.1A)
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
03Q  A   1 (-3.3A)
03Q  A   1 (-4.0A)
03Q  A   1 (-4.2A)
 0.76A 1xkkA-3pp0A:
29.5		 1xkkA-3pp0A:
73.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		6 ALA A 576
THR A 625
GLY A 631
LEU A 683
ASP A 694
PHE A 695
 STU  A   1 (-3.3A)
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
None
 0.86A 1xkkA-3ppzA:
28.4		 1xkkA-3ppzA:
32.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4t ACTIVIN RECEPTOR
TYPE-2A

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 217
THR A 267
GLY A 273
LEU A 329
ASP A 340
PHE A 341
 TAK  A   2 (-3.5A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
None
None
 0.88A 1xkkA-3q4tA:
24.6		 1xkkA-3q4tA:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 443
THR A 489
GLY A 495
CYH A 496
LEU A 498
ARG A 502
LEU A 543
 PP2  A   1 (-3.2A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.2A)
None
None
None
PP2  A   1 (-4.6A)
 0.81A 1xkkA-3sxsA:
24.7		 1xkkA-3sxsA:
29.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  96
GLY A 150
LEU A 198
ASP A 209
PHE A 210
 ANP  A 401 (-3.2A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
MG  A 402 (-3.2A)
CHU  A 403 (-3.8A)
 0.43A 1xkkA-3wigA:
24.5		 1xkkA-3wigA:
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A2032
LEU A2035
ARG A2039
LEU A2086
ASP A2102
PHE A2103
 VGH  A3000 (-3.5A)
None
None
VGH  A3000 (-4.3A)
None
None
 0.90A 1xkkA-3zbfA:
24.5		 1xkkA-3zbfA:
38.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 649
THR A 697
GLY A 703
LEU A 751
ASP A 762
PHE A 763
 None
 0.91A 1xkkA-3zfxA:
31.6		 1xkkA-3zfxA:
36.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		6 ALA A 233
THR A 283
GLY A 289
ASP A 293
LEU A 343
ASP A 354
 TAK  A1507 (-3.3A)
TAK  A1507 (-3.6A)
TAK  A1507 (-3.5A)
None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.5A)
 0.73A 1xkkA-4c02A:
19.4		 1xkkA-4c02A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		7 ALA A 267
GLY A 324
LEU A 327
LEU A 371
THR A 381
ASP A 382
PHE A 383
 None
 1.06A 1xkkA-4c0tA:
20.8		 1xkkA-4c0tA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e93 TYROSINE-PROTEIN
KINASE FES/FPS

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		7 ALA A 588
GLY A 642
LEU A 645
ARG A 649
LEU A 690
ASP A 701
PHE A 702
 GUI  A 901 (-3.4A)
GUI  A 901 (-3.5A)
None
None
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
None
 0.83A 1xkkA-4e93A:
31.7		 1xkkA-4e93A:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		6 ALA A 400
MET A 424
GLY A 454
LEU A 501
ASP A 512
PHE A 513
 ANP  A 701 (-3.3A)
None
ANP  A 701 ( 4.2A)
ANP  A 701 (-4.5A)
MG  A 702 ( 3.1A)
None
 0.96A 1xkkA-4fl3A:
21.9		 1xkkA-4fl3A:
22.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 853
GLY A 908
CYH A 909
ASP A 912
LEU A 956
PHE A 968
 19S  A1201 (-3.3A)
19S  A1201 ( 3.8A)
None
None
19S  A1201 (-4.5A)
None
 0.85A 1xkkA-4hviA:
30.4		 1xkkA-4hviA:
33.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 908
CYH A 909
ASP A 912
LEU A 956
ASP A 967
PHE A 968
 19S  A1201 ( 3.8A)
None
None
19S  A1201 (-4.5A)
19S  A1201 ( 4.1A)
None
 0.94A 1xkkA-4hviA:
30.4		 1xkkA-4hviA:
33.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		9 ALA A 156
MET A 181
THR A 205
GLY A 211
LEU A 214
ASP A 215
ARG A 218
ASP A 270
PHE A 271
 None
 0.95A 1xkkA-4hzsA:
21.6		 1xkkA-4hzsA:
36.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		9 ALA A 156
THR A 205
GLY A 211
LEU A 214
ASP A 215
ARG A 218
LEU A 259
ASP A 270
PHE A 271
 None
 0.88A 1xkkA-4hzsA:
21.6		 1xkkA-4hzsA:
36.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 156
MET A 181
THR A 205
GLY A 211
LEU A 214
ASP A 215
ARG A 218
LEU A 259
 1G0  A 401 (-3.6A)
1G0  A 401 (-4.0A)
1G0  A 401 (-3.2A)
1G0  A 401 ( 4.5A)
None
None
None
1G0  A 401 (-4.6A)
 1.32A 1xkkA-4id7A:
30.5		 1xkkA-4id7A:
34.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 MET A 181
THR A 205
GLY A 211
LEU A 214
ASP A 215
ARG A 218
LEU A 259
ASP A 270
 1G0  A 401 (-4.0A)
1G0  A 401 (-3.2A)
1G0  A 401 ( 4.5A)
None
None
None
1G0  A 401 (-4.6A)
None
 1.27A 1xkkA-4id7A:
30.5		 1xkkA-4id7A:
34.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 ALA A 293
GLY A 344
LEU A 347
ASP A 348
LEU A 393
ASP A 404
PHE A 405
 0J9  A 601 (-3.3A)
0J9  A 601 ( 4.1A)
None
None
0J9  A 601 (-4.5A)
0J9  A 601 (-3.1A)
None
 0.43A 1xkkA-4k11A:
33.1		 1xkkA-4k11A:
26.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 MET A 314
GLY A 344
LEU A 347
ASP A 348
LEU A 393
ASP A 404
PHE A 405
 None
0J9  A 601 ( 4.1A)
None
None
0J9  A 601 (-4.5A)
0J9  A 601 (-3.1A)
None
 0.76A 1xkkA-4k11A:
33.1		 1xkkA-4k11A:
26.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		6 ALA A  49
THR A  95
GLY A 101
LEU A 150
ASP A 161
PHE A 162
 ANP  A 401 (-3.1A)
ANP  A 401 (-3.8A)
None
ANP  A 401 (-4.8A)
MG  A 403 ( 3.1A)
None
 0.61A 1xkkA-4m69A:
27.3		 1xkkA-4m69A:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		6 ALA A  45
GLY A 101
ASP A 105
LEU A 148
ASP A 159
PHE A 160
 STU  A 601 (-3.2A)
STU  A 601 ( 3.8A)
None
STU  A 601 (-4.2A)
STU  A 601 (-3.7A)
None
 1.19A 1xkkA-4rewA:
23.1		 1xkkA-4rewA:
21.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		7 ALA A  35
THR A  81
GLY A  87
LEU A  90
ASP A  91
ARG A  94
LEU A 136
 ACP  A1264 (-2.9A)
ACP  A1264 (-4.5A)
ACP  A1264 (-3.5A)
None
None
None
ACP  A1264 ( 4.8A)
 0.72A 1xkkA-4ueuA:
29.0		 1xkkA-4ueuA:
34.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		6 ALA A  35
THR A  81
LEU A  90
ARG A  94
LEU A 136
PHE A 148
 ACP  A1264 (-2.9A)
ACP  A1264 (-4.5A)
None
None
ACP  A1264 ( 4.8A)
None
 0.97A 1xkkA-4ueuA:
29.0		 1xkkA-4ueuA:
34.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		6 GLY A  87
LEU A  90
ASP A  91
ARG A  94
LEU A 136
ASP A 147
 ACP  A1264 (-3.5A)
None
None
None
ACP  A1264 ( 4.8A)
None
 0.76A 1xkkA-4ueuA:
29.0		 1xkkA-4ueuA:
34.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uy9 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 169
GLY A 226
LEU A 275
THR A 293
ASP A 294
PHE A 295
 None
 0.57A 1xkkA-4uy9A:
27.6		 1xkkA-4uy9A:
30.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 6 ALA B 288
THR B 334
GLY B 340
LEU B 343
ASP B 344
LEU B 389
 1N1  B 601 (-3.5A)
1N1  B 601 (-3.3A)
1N1  B 601 (-3.5A)
None
None
1N1  B 601 (-4.3A)
 0.87A 1xkkA-4xeyB:
26.3		 1xkkA-4xeyB:
29.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 6 THR B 334
GLY B 340
LEU B 343
ASP B 344
ARG B 347
LEU B 389
 1N1  B 601 (-3.3A)
1N1  B 601 (-3.5A)
None
None
None
1N1  B 601 (-4.3A)
 0.68A 1xkkA-4xeyB:
26.3		 1xkkA-4xeyB:
29.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		9 ALA A 428
MET A 449
THR A 474
GLY A 480
CYH A 481
LEU A 483
LEU A 528
ASP A 539
PHE A 540
 None
 1.09A 1xkkA-4xi2A:
30.9		 1xkkA-4xi2A:
25.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		9 MET A 449
THR A 474
GLY A 480
CYH A 481
LEU A 483
ARG A 487
LEU A 528
ASP A 539
PHE A 540
 None
 0.92A 1xkkA-4xi2A:
30.9		 1xkkA-4xi2A:
25.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		7 ALA A 428
GLY A 480
CYH A 481
LEU A 483
LEU A 528
ASP A 539
PHE A 540
 746  A 702 (-2.4A)
746  A 702 (-3.6A)
None
None
746  A 702 (-4.4A)
746  A 702 (-3.7A)
None
 0.83A 1xkkA-4y93A:
31.1		 1xkkA-4y93A:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		7 ALA A 428
THR A 474
GLY A 480
CYH A 481
LEU A 483
LEU A 528
PHE A 540
 746  A 702 (-2.4A)
746  A 702 (-3.7A)
746  A 702 (-3.6A)
None
None
746  A 702 (-4.4A)
None
 0.86A 1xkkA-4y93A:
31.1		 1xkkA-4y93A:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		7 GLY A 480
CYH A 481
LEU A 483
ARG A 487
LEU A 528
ASP A 539
PHE A 540
 746  A 702 (-3.6A)
None
None
None
746  A 702 (-4.4A)
746  A 702 (-3.7A)
None
 0.73A 1xkkA-4y93A:
31.1		 1xkkA-4y93A:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		7 THR A 474
GLY A 480
CYH A 481
LEU A 483
ARG A 487
LEU A 528
PHE A 540
 746  A 702 (-3.7A)
746  A 702 (-3.6A)
None
None
None
746  A 702 (-4.4A)
None
 0.58A 1xkkA-4y93A:
31.1		 1xkkA-4y93A:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 488
THR A 539
GLY A 545
LEU A 595
ASP A 606
PHE A 607
 4CV  A 801 (-3.5A)
4CV  A 801 (-2.8A)
4CV  A 801 ( 4.0A)
4CV  A 801 (-4.4A)
4CV  A 801 (-3.5A)
None
 1.00A 1xkkA-4yffA:
25.4		 1xkkA-4yffA:
26.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 ALA A  55
THR A 105
GLY A 111
ASP A 115
LEU A 158
PHE A 173
 ADP  A 506 (-3.3A)
ADP  A 506 ( 4.6A)
None
None
ADP  A 506 (-4.7A)
None
 1.06A 1xkkA-4ysjA:
23.5		 1xkkA-4ysjA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  44
GLY A  98
ASP A 102
LEU A 145
ASP A 165
PHE A 166
 51W  A 401 (-3.4A)
51W  A 401 (-3.7A)
None
51W  A 401 (-4.5A)
GOL  A 404 (-3.2A)
None
 0.94A 1xkkA-5ci7A:
22.7		 1xkkA-5ci7A:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  52
GLY A 111
LEU A 160
ASP A 171
PHE A 172
 ALA  A  52 (-0.0A)
GLY  A 111 (-0.0A)
LEU  A 160 (-0.6A)
ASP  A 171 ( 0.5A)
PHE  A 172 ( 1.3A)
 0.51A 1xkkA-5d7aA:
24.8		 1xkkA-5d7aA:
25.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 928
GLY A 984
ASP A 988
LEU A1030
ASP A1041
PHE A1042
 5U3  A1200 (-3.5A)
5U3  A1200 (-3.2A)
None
5U3  A1200 (-4.4A)
5U3  A1200 ( 4.9A)
None
 0.99A 1xkkA-5f1zA:
24.1		 1xkkA-5f1zA:
30.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A  43
THR A  82
GLY A  88
ASP A  92
ASP A 151
PHE A 152
 032  A 401 (-3.2A)
032  A 401 (-3.7A)
032  A 401 ( 4.0A)
032  A 401 (-4.3A)
032  A 401 (-4.6A)
032  A 401 (-4.1A)
 0.75A 1xkkA-5hesA:
28.0		 1xkkA-5hesA:
25.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta) 		PF00069
(Pkinase) 		6 GLY A 100
ASP A 104
LEU A 147
THR A 160
ASP A 161
PHE A 162
 None
 1.05A 1xkkA-5ig1A:
17.7		 1xkkA-5ig1A:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		6 ALA A  43
GLY A  99
ASP A 103
LEU A 146
ASP A 157
PHE A 158
 STU  A 601 (-3.3A)
STU  A 601 ( 4.0A)
None
STU  A 601 (-4.5A)
STU  A 601 (-3.5A)
None
 1.13A 1xkkA-5isoA:
23.1		 1xkkA-5isoA:
20.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 ALA A 743
GLY A 796
CYH A 797
LEU A 799
ASP A 800
ARG A 803
LEU A 844
THR A 854
ASP A 855
PHE A 856
 6HJ  A1101 (-3.1A)
6HJ  A1101 ( 4.5A)
6HJ  A1101 (-1.6A)
None
6HJ  A1101 ( 4.1A)
None
6HJ  A1101 ( 4.8A)
6HJ  A1101 (-3.9A)
6HJ  A1101 (-4.3A)
None
 0.81A 1xkkA-5j9zA:
32.5		 1xkkA-5j9zA:
99.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 297
GLY A 350
ASP A 354
LEU A 396
THR A 406
PHE A 408
 IPW  A 601 (-3.5A)
IPW  A 601 ( 3.8A)
None
IPW  A 601 (-4.5A)
IPW  A 601 (-3.7A)
None
 0.79A 1xkkA-5kbrA:
22.3		 1xkkA-5kbrA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  60
GLY A 116
LEU A 163
THR A 173
PHE A 175
 STU  A 901 (-3.3A)
STU  A 901 (-3.5A)
STU  A 901 (-4.5A)
STU  A 901 (-3.5A)
None
 0.44A 1xkkA-5lohA:
16.7		 1xkkA-5lohA:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		6 ALA A 909
GLY A 962
ASP A 966
LEU A1016
ASP A1027
PHE A1028
 ATP  A1200 (-3.5A)
ATP  A1200 ( 4.0A)
ATP  A1200 (-3.9A)
ATP  A1200 (-4.6A)
ATP  A1200 (-4.1A)
None
 1.00A 1xkkA-5lpyA:
23.0		 1xkkA-5lpyA:
26.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 7 ALA A 917
THR A 963
GLY A 969
LEU A1017
THR A1027
ASP A1028
PHE A1029
 ANP  A1201 (-3.3A)
ANP  A1201 (-3.9A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
ANP  A1201 ( 4.9A)
MG  A1202 ( 3.0A)
None
 0.61A 1xkkA-5wnoA:
35.6		 1xkkA-5wnoA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53

(Saccharomyces
cerevisiae) 		no annotation 7 ALA A 225
GLY A 279
ASP A 283
LEU A 326
THR A 338
ASP A 339
PHE A 340
 None
 1.06A 1xkkA-5xzwA:
18.7		 1xkkA-5xzwA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 6 ALA A  54
GLY A 105
ARG A 112
LEU A 153
ASP A 164
PHE A 165
 ANP  A 501 ( 3.7A)
ANP  A 501 ( 4.0A)
None
ANP  A 501 (-4.6A)
MG  A 502 ( 3.1A)
None
 0.93A 1xkkA-6ao5A:
24.6		 1xkkA-6ao5A:
26.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 6 ALA A  54
MET A  74
GLY A 105
LEU A 153
ASP A 164
PHE A 165
 ANP  A 501 ( 3.7A)
None
ANP  A 501 ( 4.0A)
ANP  A 501 (-4.6A)
MG  A 502 ( 3.1A)
None
 0.72A 1xkkA-6ao5A:
24.6		 1xkkA-6ao5A:
26.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1

(Homo sapiens) 		no annotation 6 ALA A 237
GLY A 294
ASP A 298
LEU A 347
ASP A 358
PHE A 359
 DL1  A 601 (-3.4A)
DL1  A 601 (-3.5A)
DL1  A 601 ( 4.9A)
DL1  A 601 (-3.9A)
DL1  A 601 (-3.1A)
None
 1.01A 1xkkA-6bfnA:
23.4		 1xkkA-6bfnA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 6 ALA A 217
MET A 239
THR A 264
GLY A 270
LEU A 273
LEU A 319
 FKY  A9001 (-3.3A)
FKY  A9001 (-4.2A)
FKY  A9001 (-3.0A)
FKY  A9001 (-3.3A)
None
FKY  A9001 ( 4.9A)
 0.98A 1xkkA-6cz4A:
30.1		 1xkkA-6cz4A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 6 MET A 239
GLY A 270
LEU A 273
ARG A 277
LEU A 319
ASP A 330
 FKY  A9001 (-4.2A)
FKY  A9001 (-3.3A)
None
None
FKY  A9001 ( 4.9A)
None
 0.92A 1xkkA-6cz4A:
30.1		 1xkkA-6cz4A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 6 MET A 239
THR A 264
GLY A 270
LEU A 273
ARG A 277
LEU A 319
 FKY  A9001 (-4.2A)
FKY  A9001 (-3.0A)
FKY  A9001 (-3.3A)
None
None
FKY  A9001 ( 4.9A)
 0.59A 1xkkA-6cz4A:
30.1		 1xkkA-6cz4A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6h20 -

(-) 		no annotation 6 ALA A 144
THR A 211
GLY A 101
LEU A 104
THR A 249
ASP A 250
 ASN  A 401 ( 4.3A)
ASN  A 401 (-4.0A)
None
None
ASN  A 401 ( 4.9A)
ASN  A 401 (-2.9A)
 1.27A 1xkkA-6h20A:
undetectable		 1xkkA-6h20A:
undetectable