SIMILAR PATTERNS OF AMINO ACIDS FOR 1XKK_A_FMMA91

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k2p TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 428
MET A 449
THR A 474
GLY A 480
CYH A 481
ASP A 539
PHE A 540
 None
 1.03A 1xkkA-1k2pA:
29.5		 1xkkA-1k2pA:
31.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k2p TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 428
THR A 474
GLY A 480
CYH A 481
LEU A 483
ARG A 487
LEU A 528
ASP A 539
PHE A 540
 None
 0.91A 1xkkA-1k2pA:
29.5		 1xkkA-1k2pA:
31.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 ALA A 220
THR A 266
GLY A 272
ASP A 276
ARG A 279
LEU A 321
 None
 0.59A 1xkkA-1k9aA:
25.7		 1xkkA-1k9aA:
26.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 THR A 266
GLY A 272
ASP A 276
ARG A 279
LEU A 321
ASP A 332
 None
 0.57A 1xkkA-1k9aA:
25.7		 1xkkA-1k9aA:
26.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 THR A 334
GLY A 340
LEU A 343
ASP A 344
ARG A 347
LEU A 389
 P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
None
None
None
P16  A   2 (-4.4A)
 0.75A 1xkkA-1opkA:
29.2		 1xkkA-1opkA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  99
GLY A 153
LEU A 201
ASP A 212
PHE A 213
 ATP  A 535 (-3.6A)
ATP  A 535 ( 4.7A)
ATP  A 535 (-4.8A)
MG  A 536 (-3.3A)
5EA  A1001 (-3.6A)
 0.51A 1xkkA-1s9iA:
24.7		 1xkkA-1s9iA:
25.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 389
GLY A 441
CYH A 442
ASP A 445
LEU A 489
PHE A 501
 None
 0.45A 1xkkA-1snxA:
22.7		 1xkkA-1snxA:
31.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 389
MET A 410
ASP A 445
LEU A 489
ASP A 500
PHE A 501
 None
 0.86A 1xkkA-1snxA:
22.7		 1xkkA-1snxA:
31.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 389
MET A 410
GLY A 441
ASP A 445
LEU A 489
PHE A 501
 None
 0.77A 1xkkA-1snxA:
22.7		 1xkkA-1snxA:
31.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 MET A 410
ASP A 445
ARG A 448
LEU A 489
ASP A 500
PHE A 501
 None
 1.12A 1xkkA-1snxA:
22.7		 1xkkA-1snxA:
31.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 MET A 410
GLY A 441
ASP A 445
ARG A 448
LEU A 489
PHE A 501
 None
 1.07A 1xkkA-1snxA:
22.7		 1xkkA-1snxA:
31.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 621
THR A 670
GLY A 676
LEU A 679
ARG A 683
LEU A 799
 STI  A   3 (-3.5A)
STI  A   3 (-3.2A)
STI  A   3 ( 3.8A)
None
None
STI  A   3 (-4.4A)
 0.63A 1xkkA-1t46A:
24.4		 1xkkA-1t46A:
31.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA X  37
THR X  82
GLY X  88
LEU X  91
ASP X  92
LEU X 137
PHE X 149
 STU  X 902 (-3.1A)
STU  X 902 (-4.1A)
STU  X 902 (-3.5A)
None
None
STU  X 902 (-4.4A)
None
 0.89A 1xkkA-2dq7X:
24.9		 1xkkA-2dq7X:
32.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 THR X  82
GLY X  88
LEU X  91
ASP X  92
LEU X 137
ASP X 148
PHE X 149
 STU  X 902 (-4.1A)
STU  X 902 (-3.5A)
None
None
STU  X 902 (-4.4A)
STU  X 902 (-3.6A)
None
 0.91A 1xkkA-2dq7X:
24.9		 1xkkA-2dq7X:
32.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		9 ALA A 293
MET A 314
THR A 338
GLY A 344
LEU A 347
ASP A 348
LEU A 393
ASP A 404
PHE A 405
 H8H  A 534 (-3.2A)
None
H8H  A 534 (-3.1A)
H8H  A 534 (-3.3A)
None
None
H8H  A 534 (-4.5A)
H8H  A 534 (-4.2A)
None
 0.89A 1xkkA-2h8hA:
33.3		 1xkkA-2h8hA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 ALA A 293
THR A 338
GLY A 344
LEU A 347
ASP A 348
LEU A 393
ASP A 404
 QUE  A   1 (-3.5A)
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
None
QUE  A   1 ( 4.1A)
QUE  A   1 (-4.4A)
None
 0.76A 1xkkA-2hckA:
31.3		 1xkkA-2hckA:
27.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 MET A 314
THR A 338
GLY A 344
LEU A 347
ASP A 348
ASP A 404
 None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
None
QUE  A   1 ( 4.1A)
None
 0.97A 1xkkA-2hckA:
31.3		 1xkkA-2hckA:
27.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 271
THR A 316
GLY A 322
LEU A 325
ASP A 326
LEU A 371
 1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
None
None
1BM  A 499 (-4.4A)
 0.66A 1xkkA-2hk5A:
25.3		 1xkkA-2hk5A:
32.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 THR A 316
GLY A 322
LEU A 325
ASP A 326
LEU A 371
ASP A 382
 1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
None
None
1BM  A 499 (-4.4A)
1BM  A 499 (-4.4A)
 0.76A 1xkkA-2hk5A:
25.3		 1xkkA-2hk5A:
32.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 269
THR A 315
GLY A 321
LEU A 324
ASP A 325
ARG A 328
LEU A 370
 GIN  A 600 (-3.1A)
GIN  A 600 (-3.4A)
None
None
None
None
GIN  A 600 (-4.7A)
 0.54A 1xkkA-2hz0A:
29.8		 1xkkA-2hz0A:
34.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 271
THR A 316
GLY A 322
ASP A 326
LEU A 371
 1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.5A)
None
1N8  A 501 ( 4.3A)
 0.48A 1xkkA-2og8A:
24.9		 1xkkA-2og8A:
33.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 MET A 637
GLY A 669
LEU A 672
ARG A 676
LEU A 785
ASP A 796
 None
 1.37A 1xkkA-2ogvA:
27.0		 1xkkA-2ogvA:
32.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 THR A 663
GLY A 669
LEU A 672
ARG A 676
LEU A 785
ASP A 796
 None
 0.92A 1xkkA-2ogvA:
27.0		 1xkkA-2ogvA:
32.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		6 ALA A  46
GLY A 109
ASP A 113
LEU A 156
THR A 166
PHE A 168
 ATP  A 381 (-3.5A)
None
None
ATP  A 381 ( 4.8A)
ATP  A 381 ( 4.6A)
None
 0.87A 1xkkA-2phkA:
21.9		 1xkkA-2phkA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		6 GLY A 109
ASP A 113
LEU A 156
THR A 166
ASP A 167
PHE A 168
 None
None
ATP  A 381 ( 4.8A)
ATP  A 381 ( 4.6A)
MN  A 382 (-2.0A)
None
 1.02A 1xkkA-2phkA:
21.9		 1xkkA-2phkA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 215
THR A 265
GLY A 271
ASP A 275
LEU A 328
ASP A 339
 ADE  A 488 (-3.2A)
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
None
ADE  A 488 (-4.4A)
None
 0.52A 1xkkA-2qluA:
24.9		 1xkkA-2qluA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 215
THR A 265
GLY A 271
LEU A 328
ASP A 339
PHE A 340
 ADE  A 488 (-3.2A)
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
None
None
 0.87A 1xkkA-2qluA:
24.9		 1xkkA-2qluA:
25.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 749
MET A 772
THR A 796
GLY A 802
LEU A 805
LEU A 850
THR A 860
ASP A 861
PHE A 862
 GW7  A   1 (-3.3A)
GW7  A   1 ( 3.8A)
GW7  A   1 (-4.0A)
GW7  A   1 (-3.6A)
None
GW7  A   1 (-4.2A)
GW7  A   1 (-3.5A)
GW7  A   1 (-4.1A)
GW7  A   1 (-3.8A)
 0.47A 1xkkA-2r4bA:
39.6		 1xkkA-2r4bA:
76.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  51
GLY A 113
ASP A 117
LEU A 160
ASP A 171
PHE A 172
 B49  A1294 (-3.2A)
B49  A1294 (-3.6A)
None
B49  A1294 (-4.4A)
B49  A1294 (-4.2A)
None
 0.96A 1xkkA-2y7jA:
22.4		 1xkkA-2y7jA:
25.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 ALA A 273
THR A 319
GLY A 325
LEU A 328
ASP A 329
LEU A 374
 None
 0.82A 1xkkA-2zv7A:
24.7		 1xkkA-2zv7A:
31.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 THR A 319
GLY A 325
LEU A 328
ASP A 329
LEU A 374
ASP A 385
 None
 0.85A 1xkkA-2zv7A:
24.7		 1xkkA-2zv7A:
31.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 220
THR A 266
GLY A 272
ASP A 276
ARG A 279
LEU A 321
 None
 0.59A 1xkkA-3d7uA:
25.6		 1xkkA-3d7uA:
32.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 THR A 266
GLY A 272
ASP A 276
ARG A 279
LEU A 321
ASP A 332
 None
 0.57A 1xkkA-3d7uA:
25.6		 1xkkA-3d7uA:
32.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 169
GLY A 226
LEU A 275
THR A 293
PHE A 295
 VIN  A6331 (-3.4A)
VIN  A6331 (-3.4A)
VIN  A6331 (-4.5A)
VIN  A6331 (-3.6A)
None
 0.48A 1xkkA-3dtcA:
28.7		 1xkkA-3dtcA:
30.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6u SERINE/THREONINE-PRO
TEIN KINASE CHK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00498
(FHA) 		7 ALA A 247
GLY A 307
ASP A 311
LEU A 354
THR A 367
ASP A 368
PHE A 369
 None
 0.78A 1xkkA-3i6uA:
22.5		 1xkkA-3i6uA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		6 ALA A  80
MET A 104
GLY A 135
ASP A 139
LEU A 182
PHE A 194
 None
 1.14A 1xkkA-3iecA:
21.7		 1xkkA-3iecA:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		6 MET A 104
GLY A 135
ASP A 139
LEU A 182
ASP A 193
PHE A 194
 None
 1.23A 1xkkA-3iecA:
21.7		 1xkkA-3iecA:
25.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kex RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 THR A 768
GLY A 774
LEU A 777
ASP A 778
ARG A 781
LEU A 822
ASP A 833
PHE A 834
 ANP  A   1 ( 4.8A)
ANP  A   1 ( 4.9A)
None
None
None
ANP  A   1 (-4.7A)
MG  A1001 ( 3.1A)
None
 0.56A 1xkkA-3kexA:
36.0		 1xkkA-3kexA:
51.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 ALA A 665
THR A 713
GLY A 719
ARG A 726
LEU A 767
ASP A 778
 None
None
GOL  A 403 (-3.4A)
None
None
None
 0.81A 1xkkA-3kulA:
31.1		 1xkkA-3kulA:
34.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		12 ALA A 719
MET A 742
THR A 766
GLY A 772
CYH A 773
LEU A 775
ASP A 776
ARG A 779
LEU A 820
THR A 830
ASP A 831
PHE A 832
 ITI  A   1 (-2.9A)
ITI  A   1 (-3.4A)
ITI  A   1 (-3.8A)
ITI  A   1 (-3.5A)
ITI  A   1 (-4.8A)
None
None
None
ITI  A   1 (-4.6A)
ITI  A   1 (-3.8A)
ITI  A   1 ( 4.6A)
ITI  A   1 (-3.6A)
 0.75A 1xkkA-3lzbA:
38.3		 1xkkA-3lzbA:
87.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 109
GLY A 165
LEU A 168
ARG A 172
LEU A 212
THR A 222
 JOZ  A 361 (-3.4A)
None
None
None
None
JOZ  A 361 (-3.7A)
 0.70A 1xkkA-3nuuA:
22.3		 1xkkA-3nuuA:
28.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 109
GLY A 165
LEU A 168
LEU A 212
THR A 222
PHE A 224
 JOZ  A 361 (-3.4A)
None
None
None
JOZ  A 361 (-3.7A)
None
 0.96A 1xkkA-3nuuA:
22.3		 1xkkA-3nuuA:
28.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A 165
LEU A 168
ARG A 172
LEU A 212
THR A 222
ASP A 223
 None
None
None
None
JOZ  A 361 (-3.7A)
SO4  A   5 ( 4.5A)
 0.80A 1xkkA-3nuuA:
22.3		 1xkkA-3nuuA:
28.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A 165
LEU A 168
LEU A 212
THR A 222
ASP A 223
PHE A 224
 None
None
None
JOZ  A 361 (-3.7A)
SO4  A   5 ( 4.5A)
None
 1.04A 1xkkA-3nuuA:
22.3		 1xkkA-3nuuA:
28.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 ALA A 751
MET A 774
THR A 798
GLY A 804
CYH A 805
LEU A 807
ASP A 808
ARG A 811
LEU A 852
THR A 862
 03Q  A   1 (-3.1A)
03Q  A   1 (-4.5A)
03Q  A   1 (-4.1A)
03Q  A   1 ( 3.9A)
None
None
None
None
03Q  A   1 (-4.4A)
03Q  A   1 (-3.3A)
 1.13A 1xkkA-3pp0A:
29.5		 1xkkA-3pp0A:
73.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 ALA A 751
THR A 798
GLY A 804
CYH A 805
LEU A 807
ASP A 808
ARG A 811
LEU A 852
THR A 862
ASP A 863
 03Q  A   1 (-3.1A)
03Q  A   1 (-4.1A)
03Q  A   1 ( 3.9A)
None
None
None
None
03Q  A   1 (-4.4A)
03Q  A   1 (-3.3A)
03Q  A   1 (-4.0A)
 0.46A 1xkkA-3pp0A:
29.5		 1xkkA-3pp0A:
73.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 751
THR A 798
GLY A 804
LEU A 852
THR A 862
ASP A 863
PHE A 864
 03Q  A   1 (-3.1A)
03Q  A   1 (-4.1A)
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
03Q  A   1 (-3.3A)
03Q  A   1 (-4.0A)
03Q  A   1 (-4.2A)
 0.76A 1xkkA-3pp0A:
29.5		 1xkkA-3pp0A:
73.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		6 ALA A 576
THR A 625
GLY A 631
LEU A 683
ASP A 694
PHE A 695
 STU  A   1 (-3.3A)
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
None
 0.86A 1xkkA-3ppzA:
28.4		 1xkkA-3ppzA:
32.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4t ACTIVIN RECEPTOR
TYPE-2A

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 217
THR A 267
GLY A 273
LEU A 329
ASP A 340
PHE A 341
 TAK  A   2 (-3.5A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
None
None
 0.88A 1xkkA-3q4tA:
24.6		 1xkkA-3q4tA:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 443
THR A 489
GLY A 495
CYH A 496
LEU A 498
ARG A 502
LEU A 543
 PP2  A   1 (-3.2A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.2A)
None
None
None
PP2  A   1 (-4.6A)
 0.81A 1xkkA-3sxsA:
24.7		 1xkkA-3sxsA:
29.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  96
GLY A 150
LEU A 198
ASP A 209
PHE A 210
 ANP  A 401 (-3.2A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
MG  A 402 (-3.2A)
CHU  A 403 (-3.8A)
 0.43A 1xkkA-3wigA:
24.5		 1xkkA-3wigA:
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A2032
LEU A2035
ARG A2039
LEU A2086
ASP A2102
PHE A2103
 VGH  A3000 (-3.5A)
None
None
VGH  A3000 (-4.3A)
None
None
 0.90A 1xkkA-3zbfA:
24.5		 1xkkA-3zbfA:
38.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 649
THR A 697
GLY A 703
LEU A 751
ASP A 762
PHE A 763
 None
 0.91A 1xkkA-3zfxA:
31.6		 1xkkA-3zfxA:
36.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		6 ALA A 233
THR A 283
GLY A 289
ASP A 293
LEU A 343
ASP A 354
 TAK  A1507 (-3.3A)
TAK  A1507 (-3.6A)
TAK  A1507 (-3.5A)
None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.5A)
 0.73A 1xkkA-4c02A:
19.4		 1xkkA-4c02A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		7 ALA A 267
GLY A 324
LEU A 327
LEU A 371
THR A 381
ASP A 382
PHE A 383
 None
 1.06A 1xkkA-4c0tA:
20.8		 1xkkA-4c0tA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e93 TYROSINE-PROTEIN
KINASE FES/FPS

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		7 ALA A 588
GLY A 642
LEU A 645
ARG A 649
LEU A 690
ASP A 701
PHE A 702
 GUI  A 901 (-3.4A)
GUI  A 901 (-3.5A)
None
None
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
None
 0.83A 1xkkA-4e93A:
31.7		 1xkkA-4e93A:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		6 ALA A 400
MET A 424
GLY A 454
LEU A 501
ASP A 512
PHE A 513
 ANP  A 701 (-3.3A)
None
ANP  A 701 ( 4.2A)
ANP  A 701 (-4.5A)
MG  A 702 ( 3.1A)
None
 0.96A 1xkkA-4fl3A:
21.9		 1xkkA-4fl3A:
22.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 853
GLY A 908
CYH A 909
ASP A 912
LEU A 956
PHE A 968
 19S  A1201 (-3.3A)
19S  A1201 ( 3.8A)
None
None
19S  A1201 (-4.5A)
None
 0.85A 1xkkA-4hviA:
30.4		 1xkkA-4hviA:
33.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 908
CYH A 909
ASP A 912
LEU A 956
ASP A 967
PHE A 968
 19S  A1201 ( 3.8A)
None
None
19S  A1201 (-4.5A)
19S  A1201 ( 4.1A)
None
 0.94A 1xkkA-4hviA:
30.4		 1xkkA-4hviA:
33.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		9 ALA A 156
MET A 181
THR A 205
GLY A 211
LEU A 214
ASP A 215
ARG A 218
ASP A 270
PHE A 271
 None
 0.95A 1xkkA-4hzsA:
21.6		 1xkkA-4hzsA:
36.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		9 ALA A 156
THR A 205
GLY A 211
LEU A 214
ASP A 215
ARG A 218
LEU A 259
ASP A 270
PHE A 271
 None
 0.88A 1xkkA-4hzsA:
21.6		 1xkkA-4hzsA:
36.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 156
MET A 181
THR A 205
GLY A 211
LEU A 214
ASP A 215
ARG A 218
LEU A 259
 1G0  A 401 (-3.6A)
1G0  A 401 (-4.0A)
1G0  A 401 (-3.2A)
1G0  A 401 ( 4.5A)
None
None
None
1G0  A 401 (-4.6A)
 1.32A 1xkkA-4id7A:
30.5		 1xkkA-4id7A:
34.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 MET A 181
THR A 205
GLY A 211
LEU A 214
ASP A 215
ARG A 218
LEU A 259
ASP A 270
 1G0  A 401 (-4.0A)
1G0  A 401 (-3.2A)
1G0  A 401 ( 4.5A)
None
None
None
1G0  A 401 (-4.6A)
None
 1.27A 1xkkA-4id7A:
30.5		 1xkkA-4id7A:
34.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 ALA A 293
GLY A 344
LEU A 347
ASP A 348
LEU A 393
ASP A 404
PHE A 405
 0J9  A 601 (-3.3A)
0J9  A 601 ( 4.1A)
None
None
0J9  A 601 (-4.5A)
0J9  A 601 (-3.1A)
None
 0.43A 1xkkA-4k11A:
33.1		 1xkkA-4k11A:
26.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 MET A 314
GLY A 344
LEU A 347
ASP A 348
LEU A 393
ASP A 404
PHE A 405
 None
0J9  A 601 ( 4.1A)
None
None
0J9  A 601 (-4.5A)
0J9  A 601 (-3.1A)
None
 0.76A 1xkkA-4k11A:
33.1		 1xkkA-4k11A:
26.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		6 ALA A  49
THR A  95
GLY A 101
LEU A 150
ASP A 161
PHE A 162
 ANP  A 401 (-3.1A)
ANP  A 401 (-3.8A)
None
ANP  A 401 (-4.8A)
MG  A 403 ( 3.1A)
None
 0.61A 1xkkA-4m69A:
27.3		 1xkkA-4m69A:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		6 ALA A  45
GLY A 101
ASP A 105
LEU A 148
ASP A 159
PHE A 160
 STU  A 601 (-3.2A)
STU  A 601 ( 3.8A)
None
STU  A 601 (-4.2A)
STU  A 601 (-3.7A)
None
 1.19A 1xkkA-4rewA:
23.1		 1xkkA-4rewA:
21.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		7 ALA A  35
THR A  81
GLY A  87
LEU A  90
ASP A  91
ARG A  94
LEU A 136
 ACP  A1264 (-2.9A)
ACP  A1264 (-4.5A)
ACP  A1264 (-3.5A)
None
None
None
ACP  A1264 ( 4.8A)
 0.72A 1xkkA-4ueuA:
29.0		 1xkkA-4ueuA:
34.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		6 ALA A  35
THR A  81
LEU A  90
ARG A  94
LEU A 136
PHE A 148
 ACP  A1264 (-2.9A)
ACP  A1264 (-4.5A)
None
None
ACP  A1264 ( 4.8A)
None
 0.97A 1xkkA-4ueuA:
29.0		 1xkkA-4ueuA:
34.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		6 GLY A  87
LEU A  90
ASP A  91
ARG A  94
LEU A 136
ASP A 147
 ACP  A1264 (-3.5A)
None
None
None
ACP  A1264 ( 4.8A)
None
 0.76A 1xkkA-4ueuA:
29.0		 1xkkA-4ueuA:
34.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uy9 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 169
GLY A 226
LEU A 275
THR A 293
ASP A 294
PHE A 295
 None
 0.57A 1xkkA-4uy9A:
27.6		 1xkkA-4uy9A:
30.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 6 ALA B 288
THR B 334
GLY B 340
LEU B 343
ASP B 344
LEU B 389
 1N1  B 601 (-3.5A)
1N1  B 601 (-3.3A)
1N1  B 601 (-3.5A)
None
None
1N1  B 601 (-4.3A)
 0.87A 1xkkA-4xeyB:
26.3		 1xkkA-4xeyB:
29.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 6 THR B 334
GLY B 340
LEU B 343
ASP B 344
ARG B 347
LEU B 389
 1N1  B 601 (-3.3A)
1N1  B 601 (-3.5A)
None
None
None
1N1  B 601 (-4.3A)
 0.68A 1xkkA-4xeyB:
26.3		 1xkkA-4xeyB:
29.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		9 ALA A 428
MET A 449
THR A 474
GLY A 480
CYH A 481
LEU A 483
LEU A 528
ASP A 539
PHE A 540
 None
 1.09A 1xkkA-4xi2A:
30.9		 1xkkA-4xi2A:
25.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		9 MET A 449
THR A 474
GLY A 480
CYH A 481
LEU A 483
ARG A 487
LEU A 528
ASP A 539
PHE A 540
 None
 0.92A 1xkkA-4xi2A:
30.9		 1xkkA-4xi2A:
25.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		7 ALA A 428
GLY A 480
CYH A 481
LEU A 483
LEU A 528
ASP A 539
PHE A 540
 746  A 702 (-2.4A)
746  A 702 (-3.6A)
None
None
746  A 702 (-4.4A)
746  A 702 (-3.7A)
None
 0.83A 1xkkA-4y93A:
31.1		 1xkkA-4y93A:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		7 ALA A 428
THR A 474
GLY A 480
CYH A 481
LEU A 483
LEU A 528
PHE A 540
 746  A 702 (-2.4A)
746  A 702 (-3.7A)
746  A 702 (-3.6A)
None
None
746  A 702 (-4.4A)
None
 0.86A 1xkkA-4y93A:
31.1		 1xkkA-4y93A:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		7 GLY A 480
CYH A 481
LEU A 483
ARG A 487
LEU A 528
ASP A 539
PHE A 540
 746  A 702 (-3.6A)
None
None
None
746  A 702 (-4.4A)
746  A 702 (-3.7A)
None
 0.73A 1xkkA-4y93A:
31.1		 1xkkA-4y93A:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		7 THR A 474
GLY A 480
CYH A 481
LEU A 483
ARG A 487
LEU A 528
PHE A 540
 746  A 702 (-3.7A)
746  A 702 (-3.6A)
None
None
None
746  A 702 (-4.4A)
None
 0.58A 1xkkA-4y93A:
31.1		 1xkkA-4y93A:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 488
THR A 539
GLY A 545
LEU A 595
ASP A 606
PHE A 607
 4CV  A 801 (-3.5A)
4CV  A 801 (-2.8A)
4CV  A 801 ( 4.0A)
4CV  A 801 (-4.4A)
4CV  A 801 (-3.5A)
None
 1.00A 1xkkA-4yffA:
25.4		 1xkkA-4yffA:
26.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 ALA A  55
THR A 105
GLY A 111
ASP A 115
LEU A 158
PHE A 173
 ADP  A 506 (-3.3A)
ADP  A 506 ( 4.6A)
None
None
ADP  A 506 (-4.7A)
None
 1.06A 1xkkA-4ysjA:
23.5		 1xkkA-4ysjA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  44
GLY A  98
ASP A 102
LEU A 145
ASP A 165
PHE A 166
 51W  A 401 (-3.4A)
51W  A 401 (-3.7A)
None
51W  A 401 (-4.5A)
GOL  A 404 (-3.2A)
None
 0.94A 1xkkA-5ci7A:
22.7		 1xkkA-5ci7A:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  52
GLY A 111
LEU A 160
ASP A 171
PHE A 172
 ALA  A  52 (-0.0A)
GLY  A 111 (-0.0A)
LEU  A 160 (-0.6A)
ASP  A 171 ( 0.5A)
PHE  A 172 ( 1.3A)
 0.51A 1xkkA-5d7aA:
24.8		 1xkkA-5d7aA:
25.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 928
GLY A 984
ASP A 988
LEU A1030
ASP A1041
PHE A1042
 5U3  A1200 (-3.5A)
5U3  A1200 (-3.2A)
None
5U3  A1200 (-4.4A)
5U3  A1200 ( 4.9A)
None
 0.99A 1xkkA-5f1zA:
24.1		 1xkkA-5f1zA:
30.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A  43
THR A  82
GLY A  88
ASP A  92
ASP A 151
PHE A 152
 032  A 401 (-3.2A)
032  A 401 (-3.7A)
032  A 401 ( 4.0A)
032  A 401 (-4.3A)
032  A 401 (-4.6A)
032  A 401 (-4.1A)
 0.75A 1xkkA-5hesA:
28.0		 1xkkA-5hesA:
25.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta) 		PF00069
(Pkinase) 		6 GLY A 100
ASP A 104
LEU A 147
THR A 160
ASP A 161
PHE A 162
 None
 1.05A 1xkkA-5ig1A:
17.7		 1xkkA-5ig1A:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		6 ALA A  43
GLY A  99
ASP A 103
LEU A 146
ASP A 157
PHE A 158
 STU  A 601 (-3.3A)
STU  A 601 ( 4.0A)
None
STU  A 601 (-4.5A)
STU  A 601 (-3.5A)
None
 1.13A 1xkkA-5isoA:
23.1		 1xkkA-5isoA:
20.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 ALA A 743
GLY A 796
CYH A 797
LEU A 799
ASP A 800
ARG A 803
LEU A 844
THR A 854
ASP A 855
PHE A 856
 6HJ  A1101 (-3.1A)
6HJ  A1101 ( 4.5A)
6HJ  A1101 (-1.6A)
None
6HJ  A1101 ( 4.1A)
None
6HJ  A1101 ( 4.8A)
6HJ  A1101 (-3.9A)
6HJ  A1101 (-4.3A)
None
 0.81A 1xkkA-5j9zA:
32.5		 1xkkA-5j9zA:
99.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 297
GLY A 350
ASP A 354
LEU A 396
THR A 406
PHE A 408
 IPW  A 601 (-3.5A)
IPW  A 601 ( 3.8A)
None
IPW  A 601 (-4.5A)
IPW  A 601 (-3.7A)
None
 0.79A 1xkkA-5kbrA:
22.3		 1xkkA-5kbrA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  60
GLY A 116
LEU A 163
THR A 173
PHE A 175
 STU  A 901 (-3.3A)
STU  A 901 (-3.5A)
STU  A 901 (-4.5A)
STU  A 901 (-3.5A)
None
 0.44A 1xkkA-5lohA:
16.7		 1xkkA-5lohA:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		6 ALA A 909
GLY A 962
ASP A 966
LEU A1016
ASP A1027
PHE A1028
 ATP  A1200 (-3.5A)
ATP  A1200 ( 4.0A)
ATP  A1200 (-3.9A)
ATP  A1200 (-4.6A)
ATP  A1200 (-4.1A)
None
 1.00A 1xkkA-5lpyA:
23.0		 1xkkA-5lpyA:
26.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 7 ALA A 917
THR A 963
GLY A 969
LEU A1017
THR A1027
ASP A1028
PHE A1029
 ANP  A1201 (-3.3A)
ANP  A1201 (-3.9A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
ANP  A1201 ( 4.9A)
MG  A1202 ( 3.0A)
None
 0.61A 1xkkA-5wnoA:
35.6		 1xkkA-5wnoA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53

(Saccharomyces
cerevisiae) 		no annotation 7 ALA A 225
GLY A 279
ASP A 283
LEU A 326
THR A 338
ASP A 339
PHE A 340
 None
 1.06A 1xkkA-5xzwA:
18.7		 1xkkA-5xzwA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 6 ALA A  54
GLY A 105
ARG A 112
LEU A 153
ASP A 164
PHE A 165
 ANP  A 501 ( 3.7A)
ANP  A 501 ( 4.0A)
None
ANP  A 501 (-4.6A)
MG  A 502 ( 3.1A)
None
 0.93A 1xkkA-6ao5A:
24.6		 1xkkA-6ao5A:
26.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 6 ALA A  54
MET A  74
GLY A 105
LEU A 153
ASP A 164
PHE A 165
 ANP  A 501 ( 3.7A)
None
ANP  A 501 ( 4.0A)
ANP  A 501 (-4.6A)
MG  A 502 ( 3.1A)
None
 0.72A 1xkkA-6ao5A:
24.6		 1xkkA-6ao5A:
26.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1

(Homo sapiens) 		no annotation 6 ALA A 237
GLY A 294
ASP A 298
LEU A 347
ASP A 358
PHE A 359
 DL1  A 601 (-3.4A)
DL1  A 601 (-3.5A)
DL1  A 601 ( 4.9A)
DL1  A 601 (-3.9A)
DL1  A 601 (-3.1A)
None
 1.01A 1xkkA-6bfnA:
23.4		 1xkkA-6bfnA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 6 ALA A 217
MET A 239
THR A 264
GLY A 270
LEU A 273
LEU A 319
 FKY  A9001 (-3.3A)
FKY  A9001 (-4.2A)
FKY  A9001 (-3.0A)
FKY  A9001 (-3.3A)
None
FKY  A9001 ( 4.9A)
 0.98A 1xkkA-6cz4A:
30.1		 1xkkA-6cz4A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 6 MET A 239
GLY A 270
LEU A 273
ARG A 277
LEU A 319
ASP A 330
 FKY  A9001 (-4.2A)
FKY  A9001 (-3.3A)
None
None
FKY  A9001 ( 4.9A)
None
 0.92A 1xkkA-6cz4A:
30.1		 1xkkA-6cz4A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 6 MET A 239
THR A 264
GLY A 270
LEU A 273
ARG A 277
LEU A 319
 FKY  A9001 (-4.2A)
FKY  A9001 (-3.0A)
FKY  A9001 (-3.3A)
None
None
FKY  A9001 ( 4.9A)
 0.59A 1xkkA-6cz4A:
30.1		 1xkkA-6cz4A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6h20 -

(-) 		no annotation 6 ALA A 144
THR A 211
GLY A 101
LEU A 104
THR A 249
ASP A 250
 ASN  A 401 ( 4.3A)
ASN  A 401 (-4.0A)
None
None
ASN  A 401 ( 4.9A)
ASN  A 401 (-2.9A)
 1.27A 1xkkA-6h20A:
undetectable		 1xkkA-6h20A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cm8 PHOSPHORYLATED MAP
KINASE P38-GAMMA

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  41
LYS A  56
LEU A  89
LEU A 107
MET A 112
 ANP  A 400 (-4.1A)
ANP  A 400 (-2.9A)
None
None
None
 0.68A 1xkkA-1cm8A:
21.2		 1xkkA-1cm8A:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LEU A 267
VAL A 275
LYS A 290
LEU A 320
MET A 337
 P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-4.5A)
None
None
 0.64A 1xkkA-1opkA:
29.2		 1xkkA-1opkA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua2 CELL DIVISION
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  18
VAL A  26
LEU A  77
LEU A  89
MET A  94
 ATP  A 381 (-4.4A)
ATP  A 381 (-4.0A)
None
None
None
 0.50A 1xkkA-1ua2A:
22.9		 1xkkA-1ua2A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua2 CELL DIVISION
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  18
VAL A  26
LYS A  41
LEU A  77
LEU A  89
 ATP  A 381 (-4.4A)
ATP  A 381 (-4.0A)
ATP  A 381 (-2.9A)
None
None
 0.76A 1xkkA-1ua2A:
22.9		 1xkkA-1ua2A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  19
VAL A  27
LEU A  79
LEU A  91
LEU A  95
 None
 0.69A 1xkkA-1zwsA:
11.9		 1xkkA-1zwsA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  19
VAL A  27
LYS A  42
LEU A  79
LEU A  91
LEU A  95
 None
 0.73A 1xkkA-2a2aA:
22.9		 1xkkA-2a2aA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b1p MITOGEN-ACTIVATED
PROTEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  78
LYS A  93
LEU A 126
LEU A 144
LEU A 148
MET A 149
 AIZ  A 501 ( 4.7A)
AIZ  A 501 (-3.8A)
None
AIZ  A 501 (-4.2A)
AIZ  A 501 ( 4.7A)
None
 0.49A 1xkkA-2b1pA:
18.4		 1xkkA-2b1pA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bdw HYPOTHETICAL PROTEIN
K11E8.1D

(Caenorhabditis
elegans) 		PF00069
(Pkinase) 		6 LEU A  19
VAL A  27
LYS A  42
LEU A  75
LEU A  87
LEU A  91
 None
 0.83A 1xkkA-2bdwA:
20.9		 1xkkA-2bdwA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 LEU A  19
VAL A  27
LYS A  42
LEU A  95
MET A  96
 ADP  A 500 (-4.3A)
ADP  A 500 (-4.3A)
ADP  A 500 (-2.9A)
ADP  A 500 ( 4.9A)
None
 0.70A 1xkkA-2f9gA:
21.2		 1xkkA-2f9gA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 LEU A 273
VAL A 281
LYS A 295
LEU A 325
MET A 341
LEU A 407
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.7A)
None
None
None
 0.58A 1xkkA-2h8hA:
33.3		 1xkkA-2h8hA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LEU A 273
VAL A 281
LYS A 295
LEU A 325
MET A 341
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
None
None
None
 0.62A 1xkkA-2hckA:
31.3		 1xkkA-2hckA:
27.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 248
VAL A 256
LYS A 271
LEU A 301
MET A 318
 GIN  A 600 ( 4.6A)
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.6A)
None
None
 0.76A 1xkkA-2hz0A:
29.8		 1xkkA-2hz0A:
34.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jam CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1G

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  29
VAL A  37
LEU A  84
LEU A  96
LEU A 100
 J60  A1305 (-3.9A)
J60  A1305 (-4.8A)
None
None
J60  A1305 (-4.4A)
 0.42A 1xkkA-2jamA:
14.8		 1xkkA-2jamA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jam CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1G

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  37
LYS A  52
LEU A  84
LEU A  96
LEU A 100
 J60  A1305 (-4.8A)
EDO  A1304 ( 2.9A)
None
None
J60  A1305 (-4.4A)
 0.59A 1xkkA-2jamA:
14.8		 1xkkA-2jamA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jc6 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1D

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  29
VAL A  37
LYS A  52
LEU A  84
LEU A  96
LEU A 100
 QPP  A1314 (-3.7A)
QPP  A1314 ( 4.6A)
None
None
None
QPP  A1314 (-4.5A)
 0.61A 1xkkA-2jc6A:
20.4		 1xkkA-2jc6A:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozo TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		6 LEU A 344
VAL A 352
LYS A 369
LEU A 401
LEU A 412
LEU A 482
 ANP  A 615 (-4.4A)
ANP  A 615 (-4.5A)
ANP  A 615 (-3.1A)
None
None
None
 0.91A 1xkkA-2ozoA:
31.6		 1xkkA-2ozoA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		6 LEU A  25
VAL A  33
LEU A  89
LEU A 101
LEU A 105
MET A 106
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
None
None
None
None
 0.56A 1xkkA-2phkA:
21.9		 1xkkA-2phkA:
26.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 724
VAL A 732
LYS A 751
LEU A 783
LEU A 794
LEU A 798
MET A 799
LEU A 864
 GW7  A   1 ( 4.2A)
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.9A)
GW7  A   1 (-3.9A)
GW7  A   1 (-4.1A)
GW7  A   1 (-4.5A)
None
GW7  A   1 ( 4.7A)
 0.33A 1xkkA-2r4bA:
39.6		 1xkkA-2r4bA:
76.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  19
VAL A  27
LYS A  42
LEU A  79
LEU A  91
LEU A  95
 ADP  A1303 ( 3.9A)
ADP  A1303 (-4.0A)
ADP  A1303 (-2.7A)
None
None
None
 0.70A 1xkkA-2w4kA:
17.1		 1xkkA-2w4kA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  52
VAL A  60
LEU A 104
LEU A 116
LEU A 120
 DKI  A1338 (-3.8A)
DKI  A1338 (-4.2A)
None
None
DKI  A1338 (-4.2A)
 0.44A 1xkkA-2w4oA:
22.1		 1xkkA-2w4oA:
27.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  60
LYS A  75
LEU A 104
LEU A 116
LEU A 120
 DKI  A1338 (-4.2A)
None
None
None
DKI  A1338 (-4.2A)
 0.63A 1xkkA-2w4oA:
22.1		 1xkkA-2w4oA:
27.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbi ACYL-COA
DEHYDROGENASE FAMILY
MEMBER 11

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		6 LEU A 127
VAL A 126
CYH A 153
LEU A 201
LEU A 219
LEU A 276
 None
 1.23A 1xkkA-2wbiA:
undetectable		 1xkkA-2wbiA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4f MYOSIN LIGHT CHAIN
KINASE FAMILY MEMBER
4

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 112
VAL A 120
LYS A 135
LEU A 166
LEU A 178
 16X  A1374 (-4.1A)
16X  A1374 (-4.8A)
16X  A1374 ( 4.3A)
None
None
 0.47A 1xkkA-2x4fA:
22.8		 1xkkA-2x4fA:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xk9 CHECKPOINT KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 226
VAL A 234
LYS A 249
LEU A 303
MET A 304
 XK9  A1511 (-3.8A)
XK9  A1511 (-4.8A)
XK9  A1511 (-4.2A)
XK9  A1511 (-4.1A)
None
 0.73A 1xkkA-2xk9A:
20.9		 1xkkA-2xk9A:
25.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  38
LEU A  93
LEU A 105
LEU A 109
MET A 110
 None
None
None
B49  A1294 ( 4.7A)
None
 0.45A 1xkkA-2y7jA:
22.4		 1xkkA-2y7jA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  38
LYS A  53
LEU A  93
LEU A 105
MET A 110
 None
 0.65A 1xkkA-2y7jA:
22.4		 1xkkA-2y7jA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2

(Mus musculus) 		PF00069
(Pkinase) 		5 LEU A  19
VAL A  27
LEU A  79
LEU A  91
LEU A  95
 AMP  A1302 (-3.7A)
AMP  A1302 (-4.2A)
None
None
AMP  A1302 ( 4.9A)
 0.55A 1xkkA-2yabA:
23.1		 1xkkA-2yabA:
25.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2

(Mus musculus) 		PF00069
(Pkinase) 		5 VAL A  27
LYS A  42
LEU A  79
LEU A  91
LEU A  95
 AMP  A1302 (-4.2A)
AMP  A1302 (-2.8A)
None
None
AMP  A1302 ( 4.9A)
 0.75A 1xkkA-2yabA:
23.1		 1xkkA-2yabA:
25.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  68
VAL A  76
LYS A  94
LEU A 127
LEU A 139
 STU  A   1 (-3.8A)
None
STU  A   1 (-2.8A)
None
None
 0.54A 1xkkA-2z7rA:
22.5		 1xkkA-2z7rA:
26.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A1002
VAL A1010
LEU A1062
LEU A1078
MET A1079
 S91  A   1 ( 4.1A)
S91  A   1 ( 4.9A)
None
S91  A   1 (-4.7A)
None
 0.57A 1xkkA-2z8cA:
22.4		 1xkkA-2z8cA:
31.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A1002
VAL A1010
LYS A1030
LEU A1062
LEU A1078
 S91  A   1 ( 4.1A)
S91  A   1 ( 4.9A)
S91  A   1 ( 4.2A)
None
S91  A   1 (-4.7A)
 0.61A 1xkkA-2z8cA:
22.4		 1xkkA-2z8cA:
31.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a14 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Thermotoga
maritima) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		5 LEU A   9
VAL A  91
LEU A 131
LEU A 138
LEU A 120
 None
 0.83A 1xkkA-3a14A:
undetectable		 1xkkA-3a14A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqr DEATH-ASSOCIATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  19
VAL A  27
LEU A  79
LEU A  91
LEU A  95
 4RB  A 401 ( 3.9A)
4RB  A 401 ( 4.4A)
PGO  A 501 ( 4.6A)
None
4RB  A 401 (-4.4A)
 0.47A 1xkkA-3bqrA:
20.9		 1xkkA-3bqrA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3coi MITOGEN-ACTIVATED
PROTEIN KINASE 13

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  39
LYS A  54
LEU A  87
LEU A 105
MET A 110
 None
 0.75A 1xkkA-3coiA:
19.1		 1xkkA-3coiA:
26.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		5 LEU A  29
VAL A  37
LEU A  86
LEU A  98
LEU A 170
 None
 0.72A 1xkkA-3dxnA:
25.2		 1xkkA-3dxnA:
27.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7o MITOGEN-ACTIVATED
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  40
LYS A  55
LEU A  88
LEU A 106
LEU A 110
MET A 111
 35F  A   1 ( 4.8A)
35F  A   1 ( 4.6A)
None
None
35F  A   1 (-4.5A)
None
 0.66A 1xkkA-3e7oA:
19.6		 1xkkA-3e7oA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  44
VAL A  52
LYS A  67
LEU A 106
LEU A 118
 985  A   1 (-4.1A)
985  A   1 (-4.5A)
985  A   1 ( 2.8A)
None
None
 0.65A 1xkkA-3f2aA:
16.9		 1xkkA-3f2aA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		5 VAL A  42
LYS A  57
LEU A  88
LEU A 100
LEU A 104
 DRK  A   1 ( 4.9A)
DRK  A   1 (-4.1A)
None
None
DRK  A   1 (-4.4A)
 0.54A 1xkkA-3f3zA:
22.2		 1xkkA-3f3zA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbz KINASE, CMGC CDK

(Giardia
intestinalis) 		PF00069
(Pkinase) 		6 LEU A  21
VAL A  29
LYS A  44
LEU A  77
LEU A  89
LEU A 162
 None
 1.10A 1xkkA-3gbzA:
18.1		 1xkkA-3gbzA:
27.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  38
LEU A  86
LEU A 104
LEU A 108
MET A 109
 NIL  A   1 ( 4.7A)
None
NIL  A   1 ( 4.3A)
NIL  A   1 ( 4.4A)
None
 0.63A 1xkkA-3gp0A:
20.5		 1xkkA-3gp0A:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  38
LYS A  53
LEU A  86
LEU A 104
LEU A 108
 NIL  A   1 ( 4.7A)
None
None
NIL  A   1 ( 4.3A)
NIL  A   1 ( 4.4A)
 0.67A 1xkkA-3gp0A:
20.5		 1xkkA-3gp0A:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hko CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 2
CALMODULIN-LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		5 VAL A  24
LYS A  39
LEU A  75
LEU A  87
LEU A  91
 ANP  A 329 (-4.4A)
ANP  A 329 (-2.7A)
None
None
ANP  A 329 ( 4.7A)
 0.79A 1xkkA-3hkoA:
20.1		 1xkkA-3hkoA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igo CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		5 LEU A  82
VAL A  90
LYS A 105
LEU A 154
LEU A 222
 ANP  A 610 ( 4.5A)
ANP  A 610 (-3.9A)
ANP  A 610 (-2.8A)
GOL  A   1 (-4.6A)
None
 0.80A 1xkkA-3igoA:
21.9		 1xkkA-3igoA:
24.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kex RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 696
VAL A 704
LYS A 723
LEU A 755
LEU A 766
 ANP  A   1 (-4.4A)
ANP  A   1 (-3.9A)
ANP  A   1 (-3.4A)
None
None
 0.40A 1xkkA-3kexA:
36.0		 1xkkA-3kexA:
51.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl8 CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE II

(Caenorhabditis
elegans) 		PF00069
(Pkinase) 		5 VAL A  27
LYS A  42
LEU A  75
LEU A  87
LEU A  91
 None
 0.56A 1xkkA-3kl8A:
21.4		 1xkkA-3kl8A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lij CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		5 LEU A  68
VAL A  76
LYS A  91
LEU A 124
LEU A 136
 ANP  A 522 (-4.6A)
ANP  A 522 (-4.1A)
ANP  A 522 (-3.5A)
None
None
 0.53A 1xkkA-3lijA:
23.2		 1xkkA-3lijA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  39
VAL A  47
LYS A  62
LEU A  96
LEU A 108
 QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-4.1A)
None
None
 0.78A 1xkkA-3lm5A:
23.3		 1xkkA-3lm5A:
27.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 694
VAL A 702
CYH A 751
LEU A 753
LEU A 768
MET A 769
 ITI  A   1 (-3.9A)
ITI  A   1 (-4.8A)
ITI  A   1 (-3.7A)
ITI  A   1 (-3.8A)
ITI  A   1 (-4.8A)
ITI  A   1 (-4.8A)
 1.14A 1xkkA-3lzbA:
38.3		 1xkkA-3lzbA:
87.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 694
VAL A 702
LEU A 753
LEU A 764
LEU A 768
MET A 769
 ITI  A   1 (-3.9A)
ITI  A   1 (-4.8A)
ITI  A   1 (-3.8A)
ITI  A   1 ( 4.2A)
ITI  A   1 (-4.8A)
ITI  A   1 (-4.8A)
 0.93A 1xkkA-3lzbA:
38.3		 1xkkA-3lzbA:
87.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 694
VAL A 702
LYS A 721
LEU A 753
LEU A 764
LEU A 768
 ITI  A   1 (-3.9A)
ITI  A   1 (-4.8A)
ITI  A   1 (-2.6A)
ITI  A   1 (-3.8A)
ITI  A   1 ( 4.2A)
ITI  A   1 (-4.8A)
 0.81A 1xkkA-3lzbA:
38.3		 1xkkA-3lzbA:
87.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 702
CYH A 751
LEU A 753
LEU A 768
MET A 769
LEU A 834
 ITI  A   1 (-4.8A)
ITI  A   1 (-3.7A)
ITI  A   1 (-3.8A)
ITI  A   1 (-4.8A)
ITI  A   1 (-4.8A)
None
 1.19A 1xkkA-3lzbA:
38.3		 1xkkA-3lzbA:
87.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 702
LEU A 753
LEU A 764
LEU A 768
MET A 769
LEU A 834
 ITI  A   1 (-4.8A)
ITI  A   1 (-3.8A)
ITI  A   1 ( 4.2A)
ITI  A   1 (-4.8A)
ITI  A   1 (-4.8A)
None
 1.01A 1xkkA-3lzbA:
38.3		 1xkkA-3lzbA:
87.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 702
LYS A 721
LEU A 753
LEU A 764
LEU A 768
LEU A 834
 ITI  A   1 (-4.8A)
ITI  A   1 (-2.6A)
ITI  A   1 (-3.8A)
ITI  A   1 ( 4.2A)
ITI  A   1 (-4.8A)
None
 0.95A 1xkkA-3lzbA:
38.3		 1xkkA-3lzbA:
87.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3niz RHODANESE FAMILY
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		5 VAL A  37
LYS A  51
LEU A  84
LEU A  96
MET A 101
 ADP  A 314 (-4.0A)
ADP  A 314 (-2.8A)
None
None
None
 0.78A 1xkkA-3nizA:
22.6		 1xkkA-3nizA:
29.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		6 LEU A 192
VAL A 200
LEU A 238
LEU A 261
LEU A 265
MET A 266
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
None
None
AMP  A 577 ( 4.9A)
None
 1.17A 1xkkA-3nyoA:
21.4		 1xkkA-3nyoA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		6 LEU A 192
VAL A 200
LEU A 249
LEU A 261
LEU A 265
MET A 266
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
None
None
AMP  A 577 ( 4.9A)
None
 0.70A 1xkkA-3nyoA:
21.4		 1xkkA-3nyoA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		6 VAL A 200
LYS A 215
LEU A 249
LEU A 261
LEU A 265
MET A 266
 AMP  A 577 (-4.3A)
AMP  A 577 (-2.8A)
None
None
AMP  A 577 ( 4.9A)
None
 0.77A 1xkkA-3nyoA:
21.4		 1xkkA-3nyoA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oht P38A

(Salmo salar) 		PF00069
(Pkinase) 		5 LYS A  54
LEU A  87
LEU A 105
LEU A 109
MET A 110
 1N1  A1000 (-4.5A)
None
1N1  A1000 (-4.2A)
1N1  A1000 (-4.7A)
None
 0.77A 1xkkA-3ohtA:
6.8		 1xkkA-3ohtA:
27.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oht P38A

(Salmo salar) 		PF00069
(Pkinase) 		5 VAL A  39
LEU A  87
LEU A 105
LEU A 109
MET A 110
 1N1  A1000 (-4.6A)
None
1N1  A1000 (-4.2A)
1N1  A1000 (-4.7A)
None
 0.77A 1xkkA-3ohtA:
6.8		 1xkkA-3ohtA:
27.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 726
VAL A 734
LEU A 785
LEU A 796
LEU A 800
MET A 801
 03Q  A   1 (-3.8A)
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.3A)
03Q  A   1 (-4.6A)
None
 0.31A 1xkkA-3pp0A:
29.5		 1xkkA-3pp0A:
73.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 734
LYS A 753
LEU A 785
LEU A 796
LEU A 800
MET A 801
 03Q  A   1 (-4.5A)
03Q  A   1 (-4.7A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.3A)
03Q  A   1 (-4.6A)
None
 0.55A 1xkkA-3pp0A:
29.5		 1xkkA-3pp0A:
73.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		5 LEU A  63
VAL A  71
LYS A  86
LEU A 130
LEU A 142
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.1A)
None
None
 0.68A 1xkkA-3q5iA:
21.2		 1xkkA-3q5iA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3soa CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA WITH A
BETA 7 LINKER

(Homo sapiens) 		PF00069
(Pkinase)
PF08332
(CaMKII_AD) 		5 LEU A  19
VAL A  27
LEU A  75
LEU A  87
LEU A  91
 DB8  A 445 (-3.5A)
DB8  A 445 (-4.5A)
None
None
None
 0.73A 1xkkA-3soaA:
19.3		 1xkkA-3soaA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Toxoplasma
gondii) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 LEU A  57
VAL A  65
LYS A  80
LEU A 114
LEU A 126
LEU A 198
 BK5  A 701 ( 4.2A)
BK5  A 701 (-4.2A)
BK5  A 701 (-3.5A)
BK5  A 701 ( 4.5A)
BK5  A 701 (-3.3A)
BK5  A 701 ( 4.9A)
 0.52A 1xkkA-3sxfA:
24.2		 1xkkA-3sxfA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		5 LEU A 295
LYS A 317
LEU A 349
LEU A 361
MET A 366
 None
 0.69A 1xkkA-3ulzA:
22.3		 1xkkA-3ulzA:
26.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w18 AURORA KINASE A

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 139
VAL A 147
LYS A 162
LEU A 196
LEU A 208
 N13  A 501 (-3.7A)
N13  A 501 ( 4.7A)
N13  A 501 (-2.9A)
N13  A 501 ( 4.8A)
N13  A 501 (-4.9A)
 0.52A 1xkkA-3w18A:
21.6		 1xkkA-3w18A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af3 AURORA KINASE B

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  83
VAL A  91
LYS A 106
LEU A 140
LEU A 152
 VX6  A 500 (-3.8A)
VX6  A 500 ( 4.8A)
VX6  A 500 (-3.3A)
None
None
 0.53A 1xkkA-4af3A:
19.0		 1xkkA-4af3A:
24.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 616
VAL A 624
LYS A 655
LEU A 687
MET A 704
 None
DI1  A1000 (-4.8A)
DI1  A1000 (-3.9A)
None
None
 0.81A 1xkkA-4ckrA:
27.4		 1xkkA-4ckrA:
31.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  15
VAL A  23
LYS A  38
LEU A  70
LEU A  84
 BX7  A 401 (-3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 ( 4.0A)
None
None
 0.73A 1xkkA-4eutA:
11.1		 1xkkA-4eutA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  26
VAL A  34
LYS A  49
LEU A  81
LEU A  93
LEU A  97
 ATP  A 401 (-3.8A)
ATP  A 401 (-4.1A)
ATP  A 401 (-3.0A)
None
None
ATP  A 401 ( 4.8A)
 0.62A 1xkkA-4fg8A:
22.8		 1xkkA-4fg8A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		5 LEU A 377
VAL A 385
LYS A 402
LEU A 446
LEU A 515
 ANP  A 701 ( 4.6A)
ANP  A 701 (-4.1A)
ANP  A 701 (-2.7A)
None
None
 0.44A 1xkkA-4fl3A:
21.9		 1xkkA-4fl3A:
22.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		6 LEU A 132
VAL A 140
LYS A 158
LEU A 192
LEU A 207
LEU A 273
 None
 0.70A 1xkkA-4hzsA:
21.6		 1xkkA-4hzsA:
36.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i93 PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE
AT5G41260

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		5 VAL A  73
LYS A  87
LEU A 118
LEU A 130
MET A 135
 None
 0.72A 1xkkA-4i93A:
23.9		 1xkkA-4i93A:
25.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 132
VAL A 140
LYS A 158
LEU A 192
LEU A 207
 1G0  A 401 ( 4.5A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.7A)
1G0  A 401 ( 3.8A)
1G0  A 401 ( 4.9A)
 0.72A 1xkkA-4id7A:
30.5		 1xkkA-4id7A:
34.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  18
VAL A  26
LYS A  41
LEU A  75
LEU A  87
 631  A 301 (-3.4A)
631  A 301 (-4.6A)
631  A 301 (-2.7A)
None
None
 0.67A 1xkkA-4jxfA:
18.4		 1xkkA-4jxfA:
25.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 LEU A 273
VAL A 281
LYS A 295
LEU A 325
MET A 341
LEU A 407
 0J9  A 601 (-4.0A)
0J9  A 601 (-4.4A)
0J9  A 601 ( 4.7A)
None
None
None
 0.76A 1xkkA-4k11A:
33.1		 1xkkA-4k11A:
26.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l68 LEUCINE-RICH REPEAT
PROTEIN KINASE-LIKE
PROTEIN

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		5 LYS A 335
LEU A 365
LEU A 377
MET A 382
LEU A 450
 None
 0.54A 1xkkA-4l68A:
22.3		 1xkkA-4l68A:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		6 VAL A  36
LYS A  51
LEU A  76
LEU A  93
MET A  98
LEU A 164
 ANP  A 401 (-4.5A)
ANP  A 401 (-2.9A)
None
None
None
None
 0.67A 1xkkA-4m69A:
27.3		 1xkkA-4m69A:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		5 LEU A  78
VAL A  86
LEU A 132
LEU A 144
LEU A 148
 STU  A 601 ( 4.0A)
STU  A 601 (-4.8A)
None
None
STU  A 601 (-4.3A)
 0.50A 1xkkA-4mvfA:
19.0		 1xkkA-4mvfA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  46
VAL A  54
LYS A  69
LEU A 121
LEU A 125
 SIN  A 401 ( 3.9A)
None
None
None
SIN  A 401 ( 4.8A)
 0.59A 1xkkA-4o38A:
18.7		 1xkkA-4o38A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgj CALCIUM-DEPENDENT
PROTEIN KINASE 4

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 LEU A  76
VAL A  84
LYS A  99
LEU A 133
LEU A 145
LEU A 218
 None
 0.65A 1xkkA-4rgjA:
23.4		 1xkkA-4rgjA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus musculus) 		PF00069
(Pkinase) 		6 VAL B  38
LYS B  53
LEU B  86
LEU B 104
LEU B 108
MET B 109
 None
39G  B 401 (-4.2A)
None
39G  B 401 ( 4.7A)
39G  B 401 ( 4.9A)
39G  B 401 (-4.8A)
 0.68A 1xkkA-4tyhB:
20.6		 1xkkA-4tyhB:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		6 LEU A 193
VAL A 201
LYS A 216
LEU A 250
LEU A 262
MET A 267
 ANW  A 601 ( 4.0A)
None
None
None
None
None
 0.65A 1xkkA-4wboA:
21.7		 1xkkA-4wboA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		5 LEU A 193
VAL A 201
LEU A 250
LEU A 262
MET A 267
 AN2  A 601 ( 4.2A)
AN2  A 601 (-4.0A)
None
None
None
 0.82A 1xkkA-4yhjA:
20.2		 1xkkA-4yhjA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		5 VAL A 201
LYS A 216
LEU A 250
LEU A 262
MET A 267
 AN2  A 601 (-4.0A)
AN2  A 601 ( 3.9A)
None
None
None
 0.81A 1xkkA-4yhjA:
20.2		 1xkkA-4yhjA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynz SERINE/THREONINE-PRO
TEIN KINASE BRSK2

(Mus musculus) 		PF00069
(Pkinase) 		5 LEU A  26
VAL A  34
LYS A  49
LEU A  82
LEU A  94
 None
 0.42A 1xkkA-4ynzA:
21.7		 1xkkA-4ynzA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		5 LEU A  34
VAL A  42
LYS A  57
LEU A  91
LEU A 103
 ADP  A 506 ( 3.8A)
ADP  A 506 (-4.3A)
ADP  A 506 (-2.4A)
None
None
 0.64A 1xkkA-4ysjA:
23.5		 1xkkA-4ysjA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awm STRESS-ACTIVATED
PROTEIN KINASE JNK

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		6 VAL A  38
LYS A  53
LEU A  86
LEU A 104
LEU A 108
MET A 109
 ANP  A 401 (-4.5A)
ANP  A 401 (-2.9A)
None
None
ANP  A 401 ( 4.8A)
None
 0.48A 1xkkA-5awmA:
19.4		 1xkkA-5awmA:
25.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		5 LEU A  20
VAL A  28
LEU A  76
LEU A  88
LEU A  92
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.7A)
None
None
ADP  A 301 ( 4.8A)
 0.46A 1xkkA-5hu3A:
16.7		 1xkkA-5hu3A:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		5 VAL A  28
LYS A  43
LEU A  76
LEU A  88
LEU A  92
 ADP  A 301 (-3.7A)
ADP  A 301 (-2.7A)
None
None
ADP  A 301 ( 4.8A)
 0.75A 1xkkA-5hu3A:
16.7		 1xkkA-5hu3A:
24.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 718
VAL A 726
CYH A 775
LEU A 777
LEU A 788
LEU A 792
MET A 793
 6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.7A)
None
None
6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.9A)
None
 0.60A 1xkkA-5j9zA:
32.5		 1xkkA-5j9zA:
99.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 726
LYS A 745
CYH A 775
LEU A 777
LEU A 788
LEU A 792
MET A 793
 6HJ  A1101 ( 4.7A)
6HJ  A1101 (-4.2A)
None
None
6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.9A)
None
 0.68A 1xkkA-5j9zA:
32.5		 1xkkA-5j9zA:
99.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		5 VAL A 897
LYS A 911
LEU A 942
LEU A 954
MET A 959
 ATP  A1200 ( 4.5A)
ATP  A1200 (-3.8A)
None
None
None
 0.77A 1xkkA-5lpyA:
23.0		 1xkkA-5lpyA:
26.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpz PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		5 VAL A 897
LYS A 911
LEU A 942
LEU A 954
MET A 959
 ADP  A1200 (-4.4A)
ADP  A1200 ( 4.3A)
None
None
None
 0.80A 1xkkA-5lpzA:
22.9		 1xkkA-5lpzA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o2c SERINE/THREONINE-PRO
TEIN KINASE WNK3

(Homo sapiens) 		PF00069
(Pkinase)
PF12202
(OSR1_C) 		5 LEU A 153
VAL A 161
LEU A 225
LEU A 229
MET A 230
 None
None
None
GOL  A 604 ( 4.8A)
None
 0.83A 1xkkA-5o2cA:
25.8		 1xkkA-5o2cA:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 116
VAL A 124
LEU A 173
LEU A 185
LEU A 189
 H8H  A 401 (-3.7A)
H8H  A 401 (-4.7A)
None
H8H  A 401 (-4.3A)
None
 0.76A 1xkkA-5vcxA:
22.7		 1xkkA-5vcxA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccf CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 1

(Homo sapiens) 		no annotation 5 VAL A 142
LYS A 157
LEU A 214
LEU A 228
LEU A 232
 H1N  A 501 (-4.4A)
H1N  A 501 (-2.8A)
None
None
H1N  A 501 (-4.3A)
 0.63A 1xkkA-6ccfA:
22.8		 1xkkA-6ccfA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cth CONCANAVALIN A-LIKE
LECTIN PROTEIN
KINASE FAMILY
PROTEIN

(Theobroma cacao) 		no annotation 5 LEU A 275
VAL A 283
LEU A 329
LEU A 341
MET A 346
 FE7  A 601 (-3.8A)
FE7  A 601 ( 4.3A)
None
None
FE7  A 601 (-4.7A)
 0.74A 1xkkA-6cthA:
21.7		 1xkkA-6cthA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cth CONCANAVALIN A-LIKE
LECTIN PROTEIN
KINASE FAMILY
PROTEIN

(Theobroma cacao) 		no annotation 5 VAL A 283
LYS A 298
LEU A 329
LEU A 341
MET A 346
 FE7  A 601 ( 4.3A)
FE7  A 601 (-3.6A)
None
None
FE7  A 601 (-4.7A)
 0.74A 1xkkA-6cthA:
21.7		 1xkkA-6cthA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 7 LEU A 197
VAL A 205
LYS A 219
LEU A 250
LEU A 266
MET A 267
LEU A 333
 FKY  A9001 (-4.1A)
FKY  A9001 ( 4.6A)
None
None
FKY  A9001 (-4.4A)
None
None
 0.83A 1xkkA-6cz4A:
30.2		 1xkkA-6cz4A:
16.67