SIMILAR PATTERNS OF AMINO ACIDS FOR 1XIU_A_9CRA201_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1air PECTATE LYASE C

(Dickeya
chrysanthemi)
PF00544
(Pec_lyase_C)
5 ILE A  33
ALA A  36
ALA A  35
ALA A  49
VAL A  82
None
0.97A 1xiuA-1airA:
undetectable
1xiuA-1airA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dqu ISOCITRATE LYASE

(Aspergillus
nidulans)
PF00463
(ICL)
5 ILE A 166
ALA A 192
ALA A 191
LEU A  59
ALA A  56
None
0.99A 1xiuA-1dquA:
undetectable
1xiuA-1dquA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dwa MYROSINASE MA1

(Sinapis alba)
PF00232
(Glyco_hydro_1)
5 ALA M  34
LEU M 455
ALA M 456
VAL M 179
LEU M 124
None
0.98A 1xiuA-1dwaM:
undetectable
1xiuA-1dwaM:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e19 CARBAMATE KINASE

(Pyrococcus
furiosus)
PF00696
(AA_kinase)
6 ILE A  37
ALA A  34
LEU A  97
ALA A  96
VAL A   5
LEU A 234
None
0.98A 1xiuA-1e19A:
undetectable
1xiuA-1e19A:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE


(Escherichia
coli)
PF00155
(Aminotran_1_2)
5 ILE A 238
ALA A 255
ALA A 256
LEU A 100
ALA A  97
None
0.88A 1xiuA-1fc4A:
undetectable
1xiuA-1fc4A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n60 CARBON MONOXIDE
DEHYDROGENASE SMALL
CHAIN


(Oligotropha
carboxidovorans)
PF00111
(Fer2)
PF01799
(Fer2_2)
5 ILE A 149
ALA A 152
ALA A 153
LEU A  90
ALA A  89
None
0.93A 1xiuA-1n60A:
undetectable
1xiuA-1n60A:
19.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uhl RETINOIC ACID
RECEPTOR RXR-BETA


(Homo sapiens)
PF00104
(Hormone_recep)
11 CYH A 340
ALA A 342
ALA A 343
GLN A 346
PHE A 384
ARG A 387
LEU A 397
ALA A 398
VAL A 413
CYH A 503
LEU A 507
None
MEI  A1001 (-3.1A)
MEI  A1001 (-3.3A)
None
MEI  A1001 (-4.5A)
MEI  A1001 (-3.6A)
MEI  A1001 ( 4.4A)
MEI  A1001 (-3.4A)
MEI  A1001 (-4.1A)
MEI  A1001 (-4.0A)
MEI  A1001 (-4.6A)
0.65A 1xiuA-1uhlA:
31.3
1xiuA-1uhlA:
76.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uhl RETINOIC ACID
RECEPTOR RXR-BETA


(Homo sapiens)
PF00104
(Hormone_recep)
11 ILE A 339
CYH A 340
ALA A 342
ALA A 343
GLN A 346
PHE A 384
ARG A 387
LEU A 397
ALA A 398
VAL A 413
CYH A 503
MEI  A1001 (-3.8A)
None
MEI  A1001 (-3.1A)
MEI  A1001 (-3.3A)
None
MEI  A1001 (-4.5A)
MEI  A1001 (-3.6A)
MEI  A1001 ( 4.4A)
MEI  A1001 (-3.4A)
MEI  A1001 (-4.1A)
MEI  A1001 (-4.0A)
0.60A 1xiuA-1uhlA:
31.3
1xiuA-1uhlA:
76.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xls RETINOIC ACID
RECEPTOR RXR-ALPHA


(Homo sapiens)
PF00104
(Hormone_recep)
12 ILE A 268
CYH A 269
ALA A 271
ALA A 272
GLN A 275
PHE A 313
ARG A 316
LEU A 326
ALA A 327
VAL A 342
CYH A 432
LEU A 436
9CR  A 801 (-3.9A)
9CR  A 801 ( 4.5A)
9CR  A 801 (-3.6A)
9CR  A 801 (-3.5A)
9CR  A 801 (-4.7A)
9CR  A 801 (-4.3A)
9CR  A 801 (-2.6A)
9CR  A 801 (-4.1A)
9CR  A 801 (-3.3A)
9CR  A 801 ( 4.3A)
9CR  A 801 ( 3.7A)
9CR  A 801 (-4.7A)
0.37A 1xiuA-1xlsA:
31.6
1xiuA-1xlsA:
82.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xv9 ORPHAN NUCLEAR
RECEPTOR NR1I3


(Homo sapiens)
PF00104
(Hormone_recep)
5 ALA B 197
ALA B 198
LEU B 267
ALA B 266
LEU B 342
None
0.92A 1xiuA-1xv9B:
18.9
1xiuA-1xv9B:
27.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yfm FUMARASE

(Saccharomyces
cerevisiae)
PF00206
(Lyase_1)
PF10415
(FumaraseC_C)
5 ILE A 391
ALA A 176
ALA A 177
GLN A 180
LEU A  70
None
0.98A 1xiuA-1yfmA:
undetectable
1xiuA-1yfmA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z05 TRANSCRIPTIONAL
REGULATOR, ROK
FAMILY


(Vibrio cholerae)
PF00480
(ROK)
5 ILE A 299
CYH A 300
ALA A 302
ALA A 303
LEU A 288
None
0.53A 1xiuA-1z05A:
undetectable
1xiuA-1z05A:
20.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1z5x ULTRASPIRACLE
PROTEIN (USP) A
HOMOLOGUE OF RXR


(Bemisia tabaci)
PF00104
(Hormone_recep)
6 ILE U 303
CYH U 304
ALA U 306
ALA U 307
LEU U 365
ALA U 362
None
0.93A 1xiuA-1z5xU:
21.7
1xiuA-1z5xU:
67.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6r MLC PROTEIN

(Escherichia
coli)
PF00480
(ROK)
5 CYH A 301
ALA A 303
ALA A 304
LEU A 290
VAL A 271
None
0.88A 1xiuA-1z6rA:
undetectable
1xiuA-1z6rA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zk7 MERCURIC REDUCTASE

(Pseudomonas
aeruginosa)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
6 ALA A 452
ALA A 451
GLN A 453
LEU A 434
ALA A 435
VAL A 356
None
None
GOL  A3003 ( 3.8A)
None
None
None
1.30A 1xiuA-1zk7A:
undetectable
1xiuA-1zk7A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpn GLYCEROL KINASE

(Thermus
thermophilus)
PF00370
(FGGY_N)
PF02782
(FGGY_C)
5 ALA A  57
ALA A  58
ALA A  29
VAL A 163
LEU A 171
None
0.82A 1xiuA-2dpnA:
undetectable
1xiuA-2dpnA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fv2 RCD1 REQUIRED FOR
CELL
DIFFERENTIATION1
HOMOLOG


(Homo sapiens)
PF04078
(Rcd1)
5 ALA A  85
GLN A  82
LEU A 130
ALA A 129
LEU A  51
None
0.69A 1xiuA-2fv2A:
undetectable
1xiuA-2fv2A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g28 PYRUVATE
DEHYDROGENASE E1
COMPONENT


(Escherichia
coli)
PF00456
(Transketolase_N)
5 CYH A 611
ALA A 613
ALA A 614
LEU A 196
LEU A 623
None
0.64A 1xiuA-2g28A:
undetectable
1xiuA-2g28A:
15.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gl8 RETINOIC ACID
RECEPTOR RXR-GAMMA


(Homo sapiens)
PF00104
(Hormone_recep)
6 PHE A  92
ARG A  95
LEU A 105
ALA A 106
VAL A 121
CYH A 211
None
0.81A 1xiuA-2gl8A:
28.0
1xiuA-2gl8A:
78.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iec UNCHARACTERIZED
PROTEIN CONSERVED IN
ARCHAEA


(Methanopyrus
kandleri)
PF04038
(DHNA)
5 ILE A  49
ALA A  52
ALA A  53
GLN A  56
VAL A  66
None
1.00A 1xiuA-2iecA:
undetectable
1xiuA-2iecA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jsw TALIN-1

(Mus musculus)
PF01608
(I_LWEQ)
5 ILE A2345
ALA A2348
ALA A2349
ALA A2466
LEU A2326
None
1.01A 1xiuA-2jswA:
undetectable
1xiuA-2jswA:
23.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2nxx ULTRASPIRACLE (USP,
NR2B4)


(Tribolium
castaneum)
PF00104
(Hormone_recep)
5 PHE A 259
ARG A 262
LEU A 272
ALA A 273
CYH A 378
None
0.69A 1xiuA-2nxxA:
26.2
1xiuA-2nxxA:
67.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oi2 MEVALONATE KINASE

(Streptococcus
pneumoniae)
PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
5 ILE A  79
ALA A  99
ALA A  98
LEU A  57
ALA A  60
None
0.96A 1xiuA-2oi2A:
undetectable
1xiuA-2oi2A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6w PUTATIVE
GLYCOSYLTRANSFERASE
(MANNOSYLTRANSFERASE
) INVOLVED IN
GLYCOSYLATING THE
PBCV-1 MAJOR CAPSID
PROTEIN


(Paramecium
bursaria
Chlorella virus
1)
PF05637
(Glyco_transf_34)
5 ILE A  61
ALA A  64
ALA A  65
LEU A   9
VAL A 136
None
0.95A 1xiuA-2p6wA:
undetectable
1xiuA-2p6wA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q2e TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B


(Methanosarcina
mazei)
PF02518
(HATPase_c)
PF09239
(Topo-VIb_trans)
5 ILE B 277
CYH B 278
ALA B 280
ALA B 281
PHE B 304
None
0.97A 1xiuA-2q2eB:
undetectable
1xiuA-2q2eB:
17.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q60 RETINOID X RECEPTOR

(Polyandrocarpa
misakiensis)
PF00104
(Hormone_recep)
5 PHE A 188
ARG A 191
ALA A 202
VAL A 217
CYH A 307
None
0.73A 1xiuA-2q60A:
27.0
1xiuA-2q60A:
69.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q8w POKEWEED ANTIVIRAL
PROTEIN


(Phytolacca
acinosa)
PF00161
(RIP)
5 ILE A 214
ALA A 217
ARG A 240
LEU A 222
ALA A 221
None
0.96A 1xiuA-2q8wA:
undetectable
1xiuA-2q8wA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qpm CYTOKININ
DEHYDROGENASE 1


(Zea mays)
PF01565
(FAD_binding_4)
PF09265
(Cytokin-bind)
5 ILE A 315
ALA A 313
LEU A 301
ALA A 302
VAL A 360
None
0.98A 1xiuA-2qpmA:
undetectable
1xiuA-2qpmA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vml PHYCOCYANIN ALPHA
CHAIN
PHYCOCYANIN BETA
CHAIN


(Gloeobacter
violaceus)
PF00502
(Phycobilisome)
5 ALA A  40
ALA A  41
ALA A 150
VAL B  31
LEU B  24
None
0.85A 1xiuA-2vmlA:
undetectable
1xiuA-2vmlA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsx EUKARYOTIC
INITIATION FACTOR 4F
SUBUNIT P150


(Saccharomyces
cerevisiae)
PF02854
(MIF4G)
5 ILE E 652
ALA E 656
LEU E 614
VAL E 673
LEU E 753
None
0.93A 1xiuA-2vsxE:
undetectable
1xiuA-2vsxE:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xax RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 1
SUBUNIT ALPHA


(Escherichia
coli)
PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone)
5 ILE A  62
ALA A  66
ALA A  65
LEU A  84
ALA A  81
None
1.01A 1xiuA-2xaxA:
undetectable
1xiuA-2xaxA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuf ARGINYL-TRNA
SYNTHETASE


(Pyrococcus
horikoshii)
PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1)
6 ILE A 394
ALA A 397
GLN A 399
LEU A 410
ALA A 407
LEU A 322
None
1.27A 1xiuA-2zufA:
undetectable
1xiuA-2zufA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afg SUBTILISIN-LIKE
SERINE PROTEASE


(Thermococcus
kodakarensis)
PF00082
(Peptidase_S8)
PF04151
(PPC)
5 ILE A 368
ALA A 415
ALA A 416
LEU A 388
ALA A 387
None
0.92A 1xiuA-3afgA:
undetectable
1xiuA-3afgA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3am6 RHODOPSIN-2

(Acetabularia
acetabulum)
PF01036
(Bac_rhodopsin)
5 ILE A  44
ALA A  47
VAL A  95
CYH A 218
LEU A 219
None
None
None
None
CLR  A 401 ( 4.6A)
0.88A 1xiuA-3am6A:
undetectable
1xiuA-3am6A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ci0 PSEUDOPILIN GSPK

(Escherichia
coli)
PF03934
(T2SSK)
5 ILE K 218
ALA K 221
LEU K 119
ALA K 118
LEU K 271
None
1.02A 1xiuA-3ci0K:
undetectable
1xiuA-3ci0K:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cir FUMARATE REDUCTASE
IRON-SULFUR SUBUNIT


(Escherichia
coli)
PF13085
(Fer2_3)
PF13183
(Fer4_8)
5 CYH B 154
ALA B 156
ALA B 157
LEU B  93
ALA B  94
SF4  B 246 (-2.2A)
None
None
None
None
1.01A 1xiuA-3cirB:
undetectable
1xiuA-3cirB:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d0q PROTEIN CALG3

(Micromonospora
echinospora)
PF06722
(DUF1205)
5 ILE A 233
ALA A 236
ALA A 237
ALA A 334
LEU A 246
None
0.93A 1xiuA-3d0qA:
undetectable
1xiuA-3d0qA:
21.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu RETINOIC ACID
RECEPTOR RXR-ALPHA


(Homo sapiens)
PF00104
(Hormone_recep)
PF00105
(zf-C4)
12 ILE A 268
CYH A 269
ALA A 271
ALA A 272
GLN A 275
PHE A 313
ARG A 316
LEU A 326
ALA A 327
VAL A 342
CYH A 432
LEU A 436
9CR  A7223 (-3.9A)
None
9CR  A7223 (-3.5A)
9CR  A7223 (-4.2A)
9CR  A7223 (-4.6A)
9CR  A7223 (-4.5A)
9CR  A7223 (-3.7A)
9CR  A7223 (-3.8A)
9CR  A7223 ( 4.7A)
9CR  A7223 ( 4.5A)
9CR  A7223 (-3.8A)
9CR  A7223 ( 4.7A)
0.67A 1xiuA-3dzuA:
30.3
1xiuA-3dzuA:
62.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5k RIBOSOME-INACTIVATIN
G PROTEIN
PD-L1/PD-L2


(Phytolacca
dioica)
PF00161
(RIP)
5 ILE A 214
ALA A 217
ARG A 240
LEU A 222
ALA A 221
None
0.95A 1xiuA-3h5kA:
undetectable
1xiuA-3h5kA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hve GIGAXONIN

(Homo sapiens)
PF00651
(BTB)
PF07707
(BACK)
5 ILE A  47
ALA A  50
ALA A  51
LEU B  20
ALA B  19
None
0.68A 1xiuA-3hveA:
undetectable
1xiuA-3hveA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hve GIGAXONIN

(Homo sapiens)
PF00651
(BTB)
PF07707
(BACK)
5 ILE A  47
ALA A  50
LEU B  20
ALA B  19
LEU A  87
None
0.79A 1xiuA-3hveA:
undetectable
1xiuA-3hveA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hve GIGAXONIN

(Homo sapiens)
PF00651
(BTB)
PF07707
(BACK)
5 ILE B  47
ALA B  50
ALA B  51
LEU A  20
ALA A  19
None
0.73A 1xiuA-3hveB:
undetectable
1xiuA-3hveB:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hve GIGAXONIN

(Homo sapiens)
PF00651
(BTB)
PF07707
(BACK)
5 ILE B  47
ALA B  50
LEU A  20
ALA A  19
LEU B  87
None
0.95A 1xiuA-3hveB:
undetectable
1xiuA-3hveB:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ic5 PUTATIVE
SACCHAROPINE
DEHYDROGENASE


(Ruegeria
pomeroyi)
PF03435
(Sacchrp_dh_NADP)
5 ILE A  82
ALA A  85
ALA A  86
LEU A  60
ALA A  61
None
0.83A 1xiuA-3ic5A:
undetectable
1xiuA-3ic5A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipc ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (AMINO ACID)


(Agrobacterium
fabrum)
PF13458
(Peripla_BP_6)
5 ILE A 286
ALA A 289
ALA A 290
LEU A 305
ALA A 304
None
0.83A 1xiuA-3ipcA:
undetectable
1xiuA-3ipcA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iv7 ALCOHOL
DEHYDROGENASE IV


(Corynebacterium
glutamicum)
PF00465
(Fe-ADH)
5 ALA A 347
ALA A 348
LEU A 357
CYH A 244
LEU A 247
None
1.02A 1xiuA-3iv7A:
undetectable
1xiuA-3iv7A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jru PROBABLE CYTOSOL
AMINOPEPTIDASE


(Xanthomonas
oryzae)
no annotation 5 ALA B 139
ALA B 138
LEU B   3
ALA B   2
VAL B  21
None
1.00A 1xiuA-3jruB:
undetectable
1xiuA-3jruB:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ktc XYLOSE ISOMERASE

(Pectobacterium
atrosepticum)
PF01261
(AP_endonuc_2)
5 ILE A 292
ALA A 295
LEU A 324
ALA A 323
VAL A 230
None
1.00A 1xiuA-3ktcA:
undetectable
1xiuA-3ktcA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0m HIT FAMILY PROTEIN

(Mycolicibacterium
smegmatis)
PF01230
(HIT)
5 ILE A  67
ALA A  70
ALA A  71
LEU A 136
ALA A 135
None
0.70A 1xiuA-3o0mA:
undetectable
1xiuA-3o0mA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o10 SACSIN

(Homo sapiens)
PF05168
(HEPN)
5 ALA A4487
ALA A4488
LEU A4451
ALA A4447
LEU A4519
None
0.92A 1xiuA-3o10A:
undetectable
1xiuA-3o10A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oks 4-AMINOBUTYRATE
TRANSAMINASE


(Mycolicibacterium
smegmatis)
PF00202
(Aminotran_3)
5 ILE A 327
ALA A 331
ALA A 330
LEU A 298
ALA A 295
None
1.00A 1xiuA-3oksA:
undetectable
1xiuA-3oksA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qtp ENOLASE 1

(Entamoeba
histolytica)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
5 ILE A 116
CYH A 117
ALA A 119
ALA A 120
LEU A 135
None
0.82A 1xiuA-3qtpA:
undetectable
1xiuA-3qtpA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N


(Escherichia
coli)
no annotation 5 ILE N 250
ALA N 249
LEU N 119
ALA N 120
LEU N 306
None
0.85A 1xiuA-3rkoN:
undetectable
1xiuA-3rkoN:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s1s RESTRICTION
ENDONUCLEASE BPUSI


(Bacillus
pumilus)
PF02384
(N6_Mtase)
PF15516
(BpuSI_N)
5 ILE A  28
CYH A  29
ALA A  31
ALA A  32
GLN A  35
None
0.92A 1xiuA-3s1sA:
undetectable
1xiuA-3s1sA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uc2 HYPOTHETICAL PROTEIN
WITH
IMMUNOGLOBULIN-LIKE
FOLD


(Pseudomonas
aeruginosa)
PF14467
(DUF4426)
5 ILE A  59
ALA A 103
GLN A 104
PHE A 105
LEU A  88
None
0.96A 1xiuA-3uc2A:
undetectable
1xiuA-3uc2A:
24.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3upn PENICILLIN-BINDING
PROTEIN A


(Mycobacterium
tuberculosis)
PF00905
(Transpeptidase)
5 ALA A 231
ALA A 232
LEU A 298
ALA A 297
LEU A 274
None
0.91A 1xiuA-3upnA:
undetectable
1xiuA-3upnA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxw ADIPONECTIN RECEPTOR
PROTEIN 2


(Homo sapiens)
PF03006
(HlyIII)
5 ILE A 322
ALA A 325
ALA A 326
LEU A 283
ALA A 279
None
0.70A 1xiuA-3wxwA:
undetectable
1xiuA-3wxwA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a7w URIDYLATE KINASE

(Helicobacter
pylori)
PF00696
(AA_kinase)
5 ILE A  39
ALA A  36
LEU A  94
ALA A  93
VAL A  10
None
0.85A 1xiuA-4a7wA:
undetectable
1xiuA-4a7wA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4au0 EXOGLUCANASE 2

(Trichoderma
reesei)
PF01341
(Glyco_hydro_6)
5 ALA A 280
ALA A 279
GLN A 281
LEU A 336
VAL A 323
None
0.99A 1xiuA-4au0A:
undetectable
1xiuA-4au0A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1


(Saccharomyces
cerevisiae)
PF16417
(CNOT1_TTP_bind)
PF16418
(CNOT1_HEAT)
PF16419
(CNOT1_HEAT_N)
6 ILE A 741
ALA A 744
ALA A 745
LEU A 714
ALA A 715
VAL A 728
None
1.14A 1xiuA-4b8bA:
undetectable
1xiuA-4b8bA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1k TRIOSEPHOSPHATE
ISOMERASE


(Burkholderia
thailandensis)
PF00121
(TIM)
5 ILE A 246
CYH A 247
ALA A 249
ALA A 250
ALA A 220
None
0.81A 1xiuA-4g1kA:
undetectable
1xiuA-4g1kA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ia4 AQUAPORIN

(Spinacia
oleracea)
PF00230
(MIP)
5 ALA A 257
ALA A 258
GLN A 261
LEU A 110
ALA A 111
None
0.80A 1xiuA-4ia4A:
undetectable
1xiuA-4ia4A:
22.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4j5x RETINOIC ACID
RECEPTOR RXR-ALPHA,
NUCLEAR RECEPTOR
COACTIVATOR 1


(Homo sapiens)
no annotation 12 ILE D 268
CYH D 269
ALA D 271
ALA D 272
GLN D 275
PHE D 313
ARG D 316
LEU D 326
ALA D 327
VAL D 342
CYH D 432
LEU D 436
None
0.55A 1xiuA-4j5xD:
30.5
1xiuA-4j5xD:
77.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jz7 CARBAMATE KINASE

(Giardia
intestinalis)
PF00696
(AA_kinase)
5 ILE A  39
ALA A  36
ALA A  35
ALA A  96
VAL A   7
None
0.87A 1xiuA-4jz7A:
undetectable
1xiuA-4jz7A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6


(Homo sapiens)
PF00069
(Pkinase)
5 ILE A 503
GLN A 660
LEU A 631
VAL A 493
LEU A 667
None
0.95A 1xiuA-4ks8A:
undetectable
1xiuA-4ks8A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m88 EXTRACELLULAR
LIGAND-BINDING
RECEPTOR


(Verminephrobacter
eiseniae)
PF13458
(Peripla_BP_6)
5 ILE A 191
ALA A 188
ALA A 187
LEU A 215
ALA A 214
None
1.01A 1xiuA-4m88A:
undetectable
1xiuA-4m88A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nn1 TRANSCRIPTIONAL
REGULATOR


(Mycobacterium
tuberculosis)
PF00440
(TetR_N)
5 ILE A  12
ALA A  15
ALA A  16
GLN A  19
ALA A  35
None
0.54A 1xiuA-4nn1A:
undetectable
1xiuA-4nn1A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p47 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT


(Ochrobactrum
anthropi)
PF03480
(DctP)
5 ILE A 260
ALA A 264
ALA A 263
LEU A 144
ALA A 145
None
1.00A 1xiuA-4p47A:
undetectable
1xiuA-4p47A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rp8 ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA


(Escherichia
coli)
PF03611
(EIIC-GAT)
5 ILE A 160
CYH A 161
ALA A 163
LEU A 110
ALA A 111
None
0.97A 1xiuA-4rp8A:
undetectable
1xiuA-4rp8A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rrj PROBABLE
THREONINE--TRNA
LIGASE 2


(Aeropyrum
pernix)
PF08915
(tRNA-Thr_ED)
5 ILE A  58
ALA A  55
ALA A  54
LEU A  99
ALA A  98
None
0.92A 1xiuA-4rrjA:
undetectable
1xiuA-4rrjA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uqg DNA POLYMERASE

(Geobacillus
stearothermophilus)
PF00476
(DNA_pol_A)
5 ILE A 804
ALA A 801
ALA A 800
GLN A 797
LEU A 862
None
0.97A 1xiuA-4uqgA:
undetectable
1xiuA-4uqgA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1u LYND

(Lyngbya
aestuarii)
PF02624
(YcaO)
6 ILE A 264
ALA A 261
ALA A 260
LEU A 134
ALA A 133
LEU A 286
None
1.24A 1xiuA-4v1uA:
undetectable
1xiuA-4v1uA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1u LYND

(Lyngbya
aestuarii)
PF02624
(YcaO)
6 ILE A 264
ALA A 261
GLN A 258
LEU A 134
ALA A 133
LEU A 286
None
1.37A 1xiuA-4v1uA:
undetectable
1xiuA-4v1uA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ


(Escherichia
coli)
PF00588
(SpoU_methylase)
6 ALA A  53
ALA A  22
LEU A  49
ALA A  50
VAL A  40
LEU A   9
None
1.08A 1xiuA-4xboA:
undetectable
1xiuA-4xboA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ


(Escherichia
coli)
PF00588
(SpoU_methylase)
6 ILE A  57
ALA A  53
ALA A  22
LEU A  49
ALA A  50
LEU A   9
None
1.43A 1xiuA-4xboA:
undetectable
1xiuA-4xboA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgj UNCHARACTERIZED
PROTEIN


(Pectobacterium
atrosepticum)
PF07005
(DUF1537)
PF17042
(DUF1357_C)
5 ILE A 211
ALA A 214
ALA A 215
LEU A 183
ALA A 184
None
0.75A 1xiuA-4xgjA:
undetectable
1xiuA-4xgjA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgj UNCHARACTERIZED
PROTEIN


(Pectobacterium
atrosepticum)
PF07005
(DUF1537)
PF17042
(DUF1357_C)
5 ILE A 211
ALA A 214
ALA A 215
LEU A 183
LEU A 224
None
0.99A 1xiuA-4xgjA:
undetectable
1xiuA-4xgjA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gt5 PECTATE LYASE

(Paenibacillus
sp. 0602)
no annotation 5 ILE A 117
ALA A 116
ALA A 115
PHE A 132
LEU A  39
None
0.95A 1xiuA-5gt5A:
undetectable
1xiuA-5gt5A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hj5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE


(Vibrio cholerae)
PF01182
(Glucosamine_iso)
5 ILE A  20
ALA A  17
ALA A  16
LEU A  52
ALA A  51
None
0.99A 1xiuA-5hj5A:
undetectable
1xiuA-5hj5A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5htv PUTATIVE XYLULOSE
KINASE


(Arabidopsis
thaliana)
PF00370
(FGGY_N)
PF02782
(FGGY_C)
6 ALA A 239
ALA A 422
LEU A 242
ALA A 243
CYH A 231
LEU A 161
None
1.26A 1xiuA-5htvA:
undetectable
1xiuA-5htvA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5irm UNCHARACTERIZED
PROTEIN


(Oryctolagus
cuniculus)
PF05729
(NACHT)
PF13516
(LRR_6)
5 ALA A 900
GLN A 897
LEU A 927
ALA A 926
LEU A 871
None
1.00A 1xiuA-5irmA:
undetectable
1xiuA-5irmA:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5v IMMUNITY PROTEIN
CDII


(Escherichia
coli)
no annotation 5 ILE C  30
ALA C  46
GLN C  49
PHE C  27
LEU C  35
None
0.95A 1xiuA-5j5vC:
undetectable
1xiuA-5j5vC:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m49 AMINOTRANSFERASE
CLASS-III


(Rhizobium
freirei)
PF00202
(Aminotran_3)
5 ILE A 199
ALA A 201
ALA A 202
VAL A 194
LEU A 187
None
0.98A 1xiuA-5m49A:
undetectable
1xiuA-5m49A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzy GLUTACONATE
COA-TRANSFERASE
FAMILY, SUBUNIT A


(Myxococcus
xanthus)
PF01144
(CoA_trans)
5 ALA A 189
ALA A 190
PHE A 157
LEU A 113
ALA A 116
None
1.00A 1xiuA-5mzyA:
undetectable
1xiuA-5mzyA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n0g PRECORRIN-8X
METHYLMUTASE


(Rhodobacter
capsulatus)
no annotation 6 ILE A  73
ALA A  71
ALA A 130
LEU A  67
ALA A  66
VAL A  80
None
1.20A 1xiuA-5n0gA:
undetectable
1xiuA-5n0gA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nzb PROFILIN-2

(Betula pendula)
no annotation 5 ILE A  27
ALA A 102
GLN A 101
LEU A 128
VAL A   7
None
1.00A 1xiuA-5nzbA:
undetectable
1xiuA-5nzbA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oaf RUVB-LIKE 1

(Homo sapiens)
no annotation 5 ALA A  82
GLN A  85
PHE A  93
LEU A  87
VAL A  66
None
1.00A 1xiuA-5oafA:
undetectable
1xiuA-5oafA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohs -

(-)
no annotation 5 ILE A 257
ALA A 260
PHE A 541
LEU A 538
ALA A 539
None
0.79A 1xiuA-5ohsA:
undetectable
1xiuA-5ohsA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uan RETINOIC ACID
RECEPTOR RXR-ALPHA


(Homo sapiens)
no annotation 12 ILE A 268
CYH A 269
ALA A 271
ALA A 272
GLN A 275
PHE A 313
ARG A 316
LEU A 326
ALA A 327
VAL A 342
CYH A 432
LEU A 436
9CR  A 503 (-4.0A)
9CR  A 503 ( 4.4A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.8A)
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
None
9CR  A 503 (-3.3A)
9CR  A 503 ( 4.8A)
0.50A 1xiuA-5uanA:
30.3
1xiuA-5uanA:
62.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uwa PROBABLE
PHOSPHOLIPID-BINDING
PROTEIN MLAC


(Escherichia
coli)
PF05494
(MlaC)
5 ALA A 108
GLN A 107
LEU A 109
ALA A 110
VAL A  68
8ND  A 301 ( 3.9A)
None
None
None
8ND  A 301 ( 4.6A)
0.95A 1xiuA-5uwaA:
undetectable
1xiuA-5uwaA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ve8 KAP123

(Kluyveromyces
lactis)
no annotation 5 ILE A 302
ALA A 305
ALA A 306
LEU A 262
ALA A 265
None
0.95A 1xiuA-5ve8A:
undetectable
1xiuA-5ve8A:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyd PHOSPHODIESTERASE

(Salpingoeca
rosetta)
no annotation 6 ALA A 119
ALA A 118
LEU A  92
ALA A  88
VAL A  55
LEU A 182
None
1.18A 1xiuA-5vydA:
undetectable
1xiuA-5vydA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA


(Komagataella
phaffii)
PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
5 ILE B 247
ALA B 229
LEU B 378
VAL B 277
LEU B 354
None
0.99A 1xiuA-5xogB:
undetectable
1xiuA-5xogB:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi RIBOSOMAL PROTEIN
S19E, PUTATIVE


(Trichomonas
vaginalis)
PF01090
(Ribosomal_S19e)
5 ILE T  68
ALA T  65
ALA T  64
LEU T  25
ALA T  26
None
0.96A 1xiuA-5xyiT:
undetectable
1xiuA-5xyiT:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi RIBOSOMAL PROTEIN
S19E, PUTATIVE


(Trichomonas
vaginalis)
PF01090
(Ribosomal_S19e)
5 ILE T  68
ALA T  65
LEU T  25
ALA T  26
LEU T 111
None
0.99A 1xiuA-5xyiT:
undetectable
1xiuA-5xyiT:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zya SPLICING FACTOR 3B
SUBUNIT 1


(Homo sapiens)
no annotation 5 ALA C 672
GLN C 669
LEU C 712
ALA C 711
LEU C 644
None
1.00A 1xiuA-5zyaC:
undetectable
1xiuA-5zyaC:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6chj DIACYLGLYCEROL
O-ACYLTRANSFERASE


(Marinobacter
hydrocarbonoclasticus)
no annotation 5 CYH A 270
ALA A 272
ALA A 273
VAL A 421
LEU A 425
None
0.77A 1xiuA-6chjA:
undetectable
1xiuA-6chjA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d95 -

(-)
no annotation 5 ILE A 129
ALA A 132
ALA A 133
LEU A 267
ALA A 266
None
0.59A 1xiuA-6d95A:
undetectable
1xiuA-6d95A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6euv POLYMERASE BASIC
PROTEIN 2


(Influenza A
virus)
no annotation 5 ILE A 310
CYH A 311
ALA A 313
ALA A 314
VAL A 518
None
1.02A 1xiuA-6euvA:
undetectable
1xiuA-6euvA:
20.81