SIMILAR PATTERNS OF AMINO ACIDS FOR 1XF1_B_ACTB1108_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ahi | 7ALPHA-HYDROXYSTEROIDDEHYDROGENASE (Escherichiacoli) |
PF13561(adh_short_C2) | 4 | GLY A 97ASN A 118ILE A 69PHE A 122 | NAI A 302 (-3.5A)NoneNAI A 302 (-3.8A)None | 0.85A | 1xf1B-1ahiA:1.9 | 1xf1B-1ahiA:13.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bvo | TRANSCRIPTION FACTORGAMBIF1 (Anophelesgambiae) |
PF00554(RHD_DNA_bind) | 4 | GLY A 148ASN A 146ILE A 75PHE A 144 | None | 0.82A | 1xf1B-1bvoA:2.7 | 1xf1B-1bvoA:10.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1exf | EXFOLIATVE TOXIN A (Staphylococcusaureus) |
PF13365(Trypsin_2) | 4 | LEU A 181GLY A 228HIS A 213ILE A 199 | None | 0.80A | 1xf1B-1exfA:undetectable | 1xf1B-1exfA:14.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hds | HEMOGLOBIN S (DEOXY)(ALPHA CHAIN) (Odocoileusvirginianus) |
PF00042(Globin) | 4 | LEU A 109HIS A 122ASN A 126PHE A 128 | None | 0.81A | 1xf1B-1hdsA:undetectable | 1xf1B-1hdsA:11.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i5e | URACILPHOSPHORIBOSYLTRANSFERASE ([Bacillus]caldolyticus) |
PF14681(UPRTase) | 4 | LEU A 118GLY A 98HIS A 99ILE A 100 | None | 0.87A | 1xf1B-1i5eA:2.3 | 1xf1B-1i5eA:12.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ihp | PHYTASE (Aspergillusficuum) |
PF00328(His_Phos_2) | 4 | LEU A 113GLY A 60HIS A 59PHE A 31 | None | 0.90A | 1xf1B-1ihpA:undetectable | 1xf1B-1ihpA:19.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1iv8 | MALTOOLIGOSYLTREHALOSE SYNTHASE (Sulfolobusacidocaldarius) |
PF00128(Alpha-amylase)PF09196(DUF1953) | 4 | GLY A 232HIS A 229ASN A 89ILE A 230 | None | 0.89A | 1xf1B-1iv8A:2.1 | 1xf1B-1iv8A:23.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lrw | METHANOLDEHYDROGENASESUBUNIT 1 (Paracoccusdenitrificans) |
PF01011(PQQ)PF13360(PQQ_2) | 4 | LEU A 158GLY A 131HIS A 132ILE A 133 | None | 0.74A | 1xf1B-1lrwA:undetectable | 1xf1B-1lrwA:20.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n47 | ISOLECTIN B4 (Vicia villosa) |
PF00139(Lectin_legB) | 4 | LEU A 105GLY A 103ASN A 129ILE A 145 | NoneTNR A1401 (-3.4A)TNR A1401 ( 3.1A)None | 0.86A | 1xf1B-1n47A:undetectable | 1xf1B-1n47A:12.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nb2 | NUCLEOSIDEDIPHOSPHATE KINASE (Virgibacillushalodenitrificans) |
PF00334(NDK) | 4 | LEU A 89GLY A 117HIS A 116ILE A 115 | None | 0.89A | 1xf1B-1nb2A:undetectable | 1xf1B-1nb2A:11.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o5o | URACILPHOSPHORIBOSYLTRANSFERASE (Thermotogamaritima) |
PF14681(UPRTase) | 4 | LEU A 118GLY A 98HIS A 99ILE A 100 | None | 0.78A | 1xf1B-1o5oA:2.7 | 1xf1B-1o5oA:13.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qmo | MANNOSE BINDINGLECTIN, FRILMANNOSE BINDINGLECTIN, FRIL (Lablabpurpureus;Lablabpurpureus) |
PF00139(Lectin_legB)PF00139(Lectin_legB) | 4 | LEU A 106GLY A 104ASN E 144ILE E 162 | NoneMAN A 302 (-3.7A)MAN A 302 ( 3.0A)None | 0.89A | 1xf1B-1qmoA:undetectable | 1xf1B-1qmoA:8.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qoz | ACETYL XYLANESTERASE (Trichodermareesei) |
PF01083(Cutinase) | 4 | LEU A 140GLY A 139HIS A 138ILE A 137 | None | 0.79A | 1xf1B-1qozA:1.9 | 1xf1B-1qozA:11.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ska | 3-PHYTASE A (Aspergillusfumigatus) |
PF00328(His_Phos_2) | 4 | LEU A 113GLY A 60HIS A 59PHE A 31 | None | 0.89A | 1xf1B-1skaA:undetectable | 1xf1B-1skaA:18.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t90 | PROBABLEMETHYLMALONATE-SEMIALDEHYDEDEHYDROGENASE (Bacillussubtilis) |
PF00171(Aldedh) | 4 | LEU A 216GLY A 240ILE A 224PHE A 226 | NoneNoneNoneNAD A1490 (-4.7A) | 0.89A | 1xf1B-1t90A:undetectable | 1xf1B-1t90A:20.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v9s | URACILPHOSPHORIBOSYLTRANSFERASE (Thermusthermophilus) |
PF14681(UPRTase) | 4 | LEU A 117GLY A 97HIS A 98ILE A 99 | None | 0.71A | 1xf1B-1v9sA:2.7 | 1xf1B-1v9sA:13.42 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1xf1 | C5A PEPTIDASE (Streptococcuspyogenes) |
PF00082(Peptidase_S8)PF02225(PA)PF06280(fn3_5)PF13585(CHU_C) | 6 | LEU A 479GLY A 483HIS A 598ASN A 600ILE A 707PHE A 709 | CIT A1101 (-3.7A)ACT A1107 (-3.8A)NoneACT A1107 (-4.1A)ACT A1107 (-3.8A)None | 0.13A | 1xf1B-1xf1A:57.6 | 1xf1B-1xf1A:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xzq | PROBABLE TRNAMODIFICATION GTPASETRME (Thermotogamaritima) |
PF10396(TrmE_N) | 4 | LEU B 34GLY B 48HIS B 47ILE B 46 | NoneNoneFON A 451 (-3.9A)None | 0.87A | 1xf1B-1xzqB:undetectable | 1xf1B-1xzqB:9.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c3w | ALPHA-AMYLASE G-6 (Bacillushalodurans) |
PF03423(CBM_25) | 4 | GLY A 39HIS A 24ASN A 68ILE A 25 | NoneGLC A1107 ( 4.4A)NoneNone | 0.86A | 1xf1B-2c3wA:undetectable | 1xf1B-2c3wA:8.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e7j | SEP-TRNA:CYS-TRNASYNTHASE (Archaeoglobusfulgidus) |
PF05889(SepSecS) | 4 | GLY A 335HIS A 334ASN A 11ILE A 333 | None | 0.76A | 1xf1B-2e7jA:2.0 | 1xf1B-2e7jA:17.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2igt | SAM DEPENDENTMETHYLTRANSFERASE (Agrobacteriumfabrum) |
PF10672(Methyltrans_SAM) | 5 | LEU A 148GLY A 144HIS A 159ASN A 138ILE A 184 | None | 1.18A | 1xf1B-2igtA:undetectable | 1xf1B-2igtA:14.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j2m | CATALASE (Exiguobacteriumoxidotolerans) |
PF00199(Catalase)PF06628(Catalase-rel) | 4 | LEU A 413GLY A 411HIS A 410ILE A 409 | None | 0.82A | 1xf1B-2j2mA:undetectable | 1xf1B-2j2mA:20.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j76 | EUKARYOTICTRANSLATIONINITIATION FACTOR 4B (Homo sapiens) |
PF00076(RRM_1) | 4 | LEU E 5GLY E 45ILE E 17PHE E 49 | None | 0.83A | 1xf1B-2j76E:undetectable | 1xf1B-2j76E:7.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2m9n | FANCONIANEMIA-ASSOCIATEDPROTEIN OF 24 KDA (Homo sapiens) |
PF12826(HHH_2) | 4 | LEU A 195HIS A 208ASN A 189ILE A 207 | None | 0.90A | 1xf1B-2m9nA:undetectable | 1xf1B-2m9nA:5.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rf4 | DNA-DIRECTED RNAPOLYMERASE I SUBUNITRPA4 (Saccharomycescerevisiae) |
PF03876(SHS2_Rpb7-N) | 4 | LEU A 147GLY A 146HIS A 144ILE A 157 | None | 0.83A | 1xf1B-2rf4A:undetectable | 1xf1B-2rf4A:13.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2riu | 3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATESYNTHASE (Candidaalbicans) |
PF00926(DHBP_synthase) | 4 | GLY A 100HIS A 128ILE A 129PHE A 93 | None | 0.80A | 1xf1B-2riuA:undetectable | 1xf1B-2riuA:12.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w5o | ALPHA-L-ARABINOFURANOSIDASE (Fusariumgraminearum) |
no annotation | 4 | LEU A 104GLY A 57ILE A 73PHE A 71 | None | 0.87A | 1xf1B-2w5oA:undetectable | 1xf1B-2w5oA:18.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wpg | AMYLOSUCRASE ORALPHA AMYLASE (Xanthomonascampestris) |
PF00128(Alpha-amylase)PF11941(DUF3459) | 5 | LEU A 453GLY A 448HIS A 519ASN A 447ILE A 395 | None | 1.32A | 1xf1B-2wpgA:undetectable | 1xf1B-2wpgA:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yjv | REGULATOR OFRIBONUCLEASEACTIVITY A (Escherichiacoli) |
PF03737(RraA-like) | 4 | LEU A 153HIS A 143ILE A 36PHE A 139 | None | 0.82A | 1xf1B-2yjvA:2.9 | 1xf1B-2yjvA:10.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3au9 | 1-DEOXY-D-XYLULOSE5-PHOSPHATEREDUCTOISOMERASE (Plasmodiumfalciparum) |
PF02670(DXP_reductoisom)PF08436(DXP_redisom_C)PF13288(DXPR_C) | 4 | LEU A 187HIS A 471ASN A 420ILE A 467 | None | 0.90A | 1xf1B-3au9A:undetectable | 1xf1B-3au9A:18.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cy5 | HEMOGLOBIN SUBUNITBETA (Bubalus bubalis) |
PF00042(Globin) | 4 | LEU B 81HIS B 77ASN B 73PHE B 71 | NoneNoneNoneHEM B 147 ( 4.6A) | 0.67A | 1xf1B-3cy5B:undetectable | 1xf1B-3cy5B:10.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cze | SUCROSE HYDROLASE (Xanthomonascitri) |
PF00128(Alpha-amylase) | 5 | LEU A 452GLY A 447HIS A 518ASN A 446ILE A 394 | None | 1.35A | 1xf1B-3czeA:undetectable | 1xf1B-3czeA:21.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d3k | ENHANCER OFMRNA-DECAPPINGPROTEIN 3 (Homo sapiens) |
PF03853(YjeF_N) | 4 | LEU A 368GLY A 342HIS A 344ILE A 378 | None | 0.86A | 1xf1B-3d3kA:undetectable | 1xf1B-3d3kA:14.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d54 | PHOSPHORIBOSYLFORMYLGLYCINAMIDINESYNTHASE 1 (Thermotogamaritima) |
PF13507(GATase_5) | 4 | LEU D 92ASN D 175ILE D 82PHE D 181 | None | 0.81A | 1xf1B-3d54D:2.0 | 1xf1B-3d54D:12.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dmp | URACILPHOSPHORIBOSYLTRANSFERASE (Burkholderiapseudomallei) |
PF14681(UPRTase) | 4 | LEU A 123GLY A 104HIS A 105ILE A 106 | None | 0.82A | 1xf1B-3dmpA:undetectable | 1xf1B-3dmpA:12.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3doh | ESTERASE (Thermotogamaritima) |
PF02230(Abhydrolase_2) | 4 | LEU A 53GLY A 50ILE A 48PHE A 134 | None | 0.79A | 1xf1B-3dohA:2.1 | 1xf1B-3dohA:18.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fpl | NADP-DEPENDENTALCOHOLDEHYDROGENASE (Clostridiumbeijerinckii;Thermoanaerobacterbrockii) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 4 | LEU A 351GLY A 326HIS A 329ILE A 330 | None | 0.81A | 1xf1B-3fplA:3.8 | 1xf1B-3fplA:17.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gwb | PEPTIDASE M16INACTIVE DOMAINFAMILY PROTEIN (Pseudomonasprotegens) |
PF05193(Peptidase_M16_C) | 4 | LEU A 285GLY A 277ASN A 273ILE A 314 | None | 0.78A | 1xf1B-3gwbA:undetectable | 1xf1B-3gwbA:19.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gz5 | MUTT/NUDIX FAMILYPROTEIN (Shewanellaoneidensis) |
PF00293(NUDIX) | 4 | LEU A 38GLY A 51HIS A 142ILE A 146 | None | 0.74A | 1xf1B-3gz5A:undetectable | 1xf1B-3gz5A:14.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gz8 | MUTT/NUDIX FAMILYPROTEIN (Shewanellaoneidensis) |
PF00293(NUDIX) | 4 | LEU A 38GLY A 51HIS A 142ILE A 146 | NoneNoneAPR A 302 (-4.0A)None | 0.75A | 1xf1B-3gz8A:undetectable | 1xf1B-3gz8A:11.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hdi | PROCESSING PROTEASE (Bacillushalodurans) |
PF00675(Peptidase_M16)PF05193(Peptidase_M16_C) | 4 | LEU A 269GLY A 262ASN A 258ILE A 298 | None | 0.82A | 1xf1B-3hdiA:undetectable | 1xf1B-3hdiA:18.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3htn | PUTATIVE DNA BINDINGPROTEIN (Bacteroidesthetaiotaomicron) |
PF03479(DUF296) | 4 | LEU A 132GLY A 119ASN A 83PHE A 159 | None | 0.81A | 1xf1B-3htnA:undetectable | 1xf1B-3htnA:10.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j0a | TOLL-LIKE RECEPTOR 5 (Homo sapiens) |
PF01582(TIR)PF13855(LRR_8) | 4 | LEU A 285GLY A 284ASN A 248PHE A 246 | None | 0.81A | 1xf1B-3j0aA:undetectable | 1xf1B-3j0aA:20.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l6d | PUTATIVEOXIDOREDUCTASE (Pseudomonasputida) |
PF03446(NAD_binding_2) | 4 | LEU A 92GLY A 120HIS A 121ILE A 97 | None | 0.90A | 1xf1B-3l6dA:undetectable | 1xf1B-3l6dA:16.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l88 | FIBER PROTEIN (HumanmastadenovirusB) |
PF00541(Adeno_knob) | 4 | LEU A 174GLY A 176ASN A 182ILE A 146 | None | 0.86A | 1xf1B-3l88A:undetectable | 1xf1B-3l88A:11.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lfu | DNA HELICASE II (Escherichiacoli) |
PF00580(UvrD-helicase)PF13361(UvrD_C) | 4 | LEU A 559GLY A 602ILE A 572PHE A 632 | None | 0.86A | 1xf1B-3lfuA:undetectable | 1xf1B-3lfuA:21.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lyx | SENSORY BOX/GGDEFDOMAIN PROTEIN (Colwelliapsychrerythraea) |
PF08447(PAS_3) | 4 | LEU A 112GLY A 113ASN A 115ILE A 20 | None | 0.89A | 1xf1B-3lyxA:undetectable | 1xf1B-3lyxA:8.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n6u | LYSR TYPE REGULATOROF TSAMBCD (Comamonastestosteroni) |
PF03466(LysR_substrate) | 4 | GLY A 92HIS A 93ILE A 94PHE A 118 | None | 0.90A | 1xf1B-3n6uA:undetectable | 1xf1B-3n6uA:11.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pps | LACCASE (Thielaviaarenaria) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 4 | LEU A 98GLY A 97HIS A 96ILE A 154 | NoneNone CU A 603 ( 3.1A)None | 0.78A | 1xf1B-3ppsA:undetectable | 1xf1B-3ppsA:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pv6 | IG-LIKEDOMAIN-CONTAININGPROTEINDKFZP686O24166/DKFZP686I21167 (Homo sapiens) |
PF07654(C1-set) | 4 | LEU A 56GLY A 103ASN A 49PHE A 51 | None | 0.70A | 1xf1B-3pv6A:3.0 | 1xf1B-3pv6A:14.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qsg | NAD-BINDINGPHOSPHOGLUCONATEDEHYDROGENASE-LIKEPROTEIN (Alicyclobacillusacidocaldarius) |
PF03807(F420_oxidored)PF09130(DUF1932) | 4 | LEU A 83GLY A 80HIS A 110ILE A 107 | None | 0.85A | 1xf1B-3qsgA:undetectable | 1xf1B-3qsgA:16.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ubd | RIBOSOMAL PROTEIN S6KINASE ALPHA-3 (Mus musculus) |
PF00069(Pkinase) | 4 | LEU A 201GLY A 205HIS A 206ILE A 207 | None | 0.89A | 1xf1B-3ubdA:undetectable | 1xf1B-3ubdA:16.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ujq | LEGUME LECTIN (Lablabpurpureus) |
PF00139(Lectin_legB) | 4 | LEU A 128GLY A 126ASN A 152ILE A 169 | NoneGAL A 301 ( 3.4A) CA A 303 (-3.6A)None | 0.90A | 1xf1B-3ujqA:undetectable | 1xf1B-3ujqA:16.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vpq | GLUTATHIONES-TRANSFERASE SIGMA (Bombyx mori) |
PF02798(GST_N)PF14497(GST_C_3) | 4 | LEU A 137GLY A 142HIS A 143ILE A 144 | NonePGO A 311 (-3.2A)PGO A 311 ( 4.1A)None | 0.85A | 1xf1B-3vpqA:undetectable | 1xf1B-3vpqA:12.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ap3 | STEROIDMONOOXYGENASE (Rhodococcusrhodochrous) |
PF00743(FMO-like) | 4 | LEU A 469GLY A 476ILE A 546PHE A 544 | None | 0.83A | 1xf1B-4ap3A:undetectable | 1xf1B-4ap3A:21.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c25 | L-FUCULOSE PHOSPHATEALDOLASE (Streptococcuspneumoniae) |
PF00596(Aldolase_II) | 4 | LEU A 15HIS A 93ASN A 27ILE A 92 | None ZN A 301 ( 3.2A)SO4 A 304 ( 3.8A)None | 0.85A | 1xf1B-4c25A:undetectable | 1xf1B-4c25A:12.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c3h | DNA-DIRECTED RNAPOLYMERASE I SUBUNITRPA43 (Saccharomycescerevisiae) |
PF03876(SHS2_Rpb7-N) | 4 | LEU G 147GLY G 146HIS G 144ILE G 157 | None | 0.78A | 1xf1B-4c3hG:undetectable | 1xf1B-4c3hG:17.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c82 | 2-C-METHYL-D-ERYTHRITOL2,4-CYCLODIPHOSPHATESYNTHASE (Plasmodiumfalciparum) |
PF02542(YgbB) | 4 | LEU A 100GLY A 118HIS A 73ILE A 227 | NoneNone ZN A1240 (-3.2A)None | 0.90A | 1xf1B-4c82A:undetectable | 1xf1B-4c82A:11.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cv7 | VIRULENCE ASSOCIATEDPROTEIN VAPB (Rhodococcushoagii) |
PF05526(R_equi_Vir) | 5 | GLY A 171HIS A 172ASN A 161ILE A 173PHE A 149 | None | 1.45A | 1xf1B-4cv7A:undetectable | 1xf1B-4cv7A:8.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hjh | PHOSPHOMANNOMUTASE (Brucellamelitensis) |
PF00408(PGM_PMM_IV)PF02878(PGM_PMM_I)PF02879(PGM_PMM_II)PF02880(PGM_PMM_III) | 4 | LEU A 82GLY A 80ASN A 78PHE A 49 | None | 0.79A | 1xf1B-4hjhA:2.3 | 1xf1B-4hjhA:21.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i0n | NECROTIC ENTERITISTOXIN B (Clostridiumperfringens) |
PF07968(Leukocidin) | 4 | LEU A 91GLY A 76ILE A 311PHE A 309 | None | 0.90A | 1xf1B-4i0nA:3.0 | 1xf1B-4i0nA:15.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k9d | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (Brugia malayi) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 4 | LEU A 254GLY A 174HIS A 170ILE A 169 | None | 0.69A | 1xf1B-4k9dA:undetectable | 1xf1B-4k9dA:15.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lob | POLYPRENYLSYNTHETASE (Acinetobacterbaumannii) |
PF00348(polyprenyl_synt) | 4 | GLY A 204HIS A 205ASN A 208PHE A 210 | GOL A 401 ( 3.8A)GOL A 401 (-3.4A)GOL A 401 (-3.8A)None | 0.83A | 1xf1B-4lobA:undetectable | 1xf1B-4lobA:16.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lsm | GLYCERALDEHYDE3-PHOSPHATEDEHYDROGENASE,CYTOSOLIC (Trypanosomacruzi) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 4 | LEU A 253GLY A 173HIS A 169ILE A 168 | None | 0.71A | 1xf1B-4lsmA:undetectable | 1xf1B-4lsmA:16.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mn8 | LRR RECEPTOR-LIKESERINE/THREONINE-PROTEIN KINASE FLS2 (Arabidopsisthaliana) |
PF00560(LRR_1)PF08263(LRRNT_2)PF13516(LRR_6)PF13855(LRR_8) | 4 | LEU A 734GLY A 712HIS A 688ILE A 689 | None | 0.80A | 1xf1B-4mn8A:undetectable | 1xf1B-4mn8A:22.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mna | LRR RECEPTOR-LIKESERINE/THREONINE-PROTEIN KINASE FLS2 (Arabidopsisthaliana) |
PF00560(LRR_1)PF08263(LRRNT_2)PF13516(LRR_6)PF13855(LRR_8) | 4 | LEU A 734GLY A 712HIS A 688ILE A 689 | None | 0.82A | 1xf1B-4mnaA:undetectable | 1xf1B-4mnaA:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o59 | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (Bos taurus) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 4 | LEU O 246GLY O 166HIS O 162ILE O 161 | None | 0.66A | 1xf1B-4o59O:undetectable | 1xf1B-4o59O:16.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p42 | EXTENDEDSYNAPTOTAGMIN-2 (Homo sapiens) |
PF00168(C2)PF17047(SMP_LBD) | 4 | GLY A 314HIS A 203ASN A 201PHE A 207 | None | 0.83A | 1xf1B-4p42A:undetectable | 1xf1B-4p42A:19.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4paf | TRAP DICARBOXYLATETRANSPORTER, DCTPSUBUNIT, PUTATIVE (Ruegeriapomeroyi) |
PF03480(DctP) | 4 | LEU A 169ASN A 182ILE A 171PHE A 180 | None | 0.87A | 1xf1B-4pafA:undetectable | 1xf1B-4pafA:16.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q8h | PAB-DEPENDENTPOLY(A)-SPECIFICRIBONUCLEASE SUBUNITPAN2 (Saccharomycescerevisiae) |
PF00929(RNase_T)PF13423(UCH_1) | 4 | GLY A 506ASN A 500ILE A 564PHE A 499 | None | 0.89A | 1xf1B-4q8hA:undetectable | 1xf1B-4q8hA:21.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uur | PUTATIVEHEMOGLOBIN-LIKEOXYGEN-BINDINGPROTEIN (Pseudoalteromonashaloplanktis) |
PF01152(Bac_globin) | 4 | LEU A 73ASN A 39ILE A 37PHE A 41 | None | 0.90A | 1xf1B-4uurA:undetectable | 1xf1B-4uurA:9.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4v39 | SIALYLTRANSFERASE (Pasteurelladagmatis) |
PF11477(PM0188) | 4 | LEU A 5HIS A 7ASN A 58ILE A 55 | None | 0.86A | 1xf1B-4v39A:undetectable | 1xf1B-4v39A:19.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wjs | RSA4 (Chaetomiumthermophilum) |
PF00400(WD40) | 5 | LEU A 400GLY A 436ASN A 432ILE A 419PHE A 438 | None | 1.44A | 1xf1B-4wjsA:undetectable | 1xf1B-4wjsA:20.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wu0 | SIMILAR TO YTER(BACILUS SUBTILIS) (Clostridiumacetobutylicum) |
PF07470(Glyco_hydro_88) | 4 | LEU A 132GLY A 131HIS A 119ILE A 127 | None | 0.75A | 1xf1B-4wu0A:undetectable | 1xf1B-4wu0A:19.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xhp | PARM HYBRID FUSIONPROTEIN (Bacillusthuringiensis) |
no annotation | 4 | LEU A 27GLY A 31ASN A 215ILE A 213 | None | 0.75A | 1xf1B-4xhpA:2.9 | 1xf1B-4xhpA:23.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xhp | PARM HYBRID FUSIONPROTEIN (Bacillusthuringiensis) |
no annotation | 4 | LEU A 470GLY A 474ASN A 658ILE A 656 | None | 0.85A | 1xf1B-4xhpA:2.9 | 1xf1B-4xhpA:23.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ysl | BETA-LACTAMASEDOMAIN PROTEIN (Pseudomonasputida) |
PF00753(Lactamase_B) | 4 | LEU A 172GLY A 178HIS A 236ILE A 237 | None | 0.88A | 1xf1B-4yslA:undetectable | 1xf1B-4yslA:14.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bo6 | SIA-ALPHA-2,3-GAL-BETA-1,4-GLCNAC-R:ALPHA2,8-SIALYLTRANSFERASE (Homo sapiens) |
PF00777(Glyco_transf_29) | 4 | LEU A 260ASN A 211ILE A 245PHE A 191 | None | 0.87A | 1xf1B-5bo6A:undetectable | 1xf1B-5bo6A:16.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c7i | GLYCERALDEHYDE-3-PHOSPHATEDEHYDROGENASE,TESTIS-SPECIFIC (Mus musculus) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 4 | LEU O 353GLY O 273HIS O 269ILE O 268 | None | 0.67A | 1xf1B-5c7iO:2.5 | 1xf1B-5c7iO:16.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c7o | GLYCERALDEHYDE-3-PHOSPHATEDEHYDROGENASE,TESTIS-SPECIFIC (Homo sapiens) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 4 | LEU O 321GLY O 241HIS O 237ILE O 236 | None | 0.67A | 1xf1B-5c7oO:2.3 | 1xf1B-5c7oO:15.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5doi | TELOMERASE-ASSOCIATED PROTEIN 19 (Tetrahymenathermophila) |
no annotation | 4 | LEU A 56HIS A 134ASN A 133ILE A 136 | None | 0.78A | 1xf1B-5doiA:undetectable | 1xf1B-5doiA:9.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e6s | INTEGRIN ALPHA-L (Homo sapiens) |
PF00092(VWA)PF01839(FG-GAP)PF08441(Integrin_alpha2) | 4 | LEU A 503GLY A 562HIS A 561ILE A 560 | None | 0.73A | 1xf1B-5e6sA:2.8 | 1xf1B-5e6sA:21.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fa1 | PUTATIVE N-ACETYLGLUCOSAMINYLTRANSFERASE (Raoultellaterrigena) |
PF05159(Capsule_synth) | 4 | LEU A 392ASN A 335ILE A 396PHE A 339 | None | 0.90A | 1xf1B-5fa1A:undetectable | 1xf1B-5fa1A:18.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fgu | GREEN FLUORESCENTPROTEIN,EXTRACELLULAR STREPTODORNASE D (Streptococcuspyogenes;Aequoreavictoria) |
PF01353(GFP)PF13930(Endonuclea_NS_2) | 4 | LEU A1189GLY A1188ASN A1211ILE A1204 | NoneSO4 A1403 (-3.7A)SO4 A1403 (-3.2A)None | 0.77A | 1xf1B-5fguA:undetectable | 1xf1B-5fguA:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fgw | EXTRACELLULARSTREPTODORNASE D (Streptococcuspyogenes) |
PF01223(Endonuclease_NS) | 4 | LEU A 189GLY A 188ASN A 211ILE A 204 | None ZN A 302 ( 4.5A) ZN A 302 (-2.8A)None | 0.87A | 1xf1B-5fgwA:undetectable | 1xf1B-5fgwA:15.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hz1 | PROBABLE LRRRECEPTOR-LIKESERINE/THREONINE-PROTEIN KINASEAT4G26540 (Arabidopsisthaliana) |
PF13855(LRR_8) | 4 | LEU B 202GLY B 179HIS B 156ILE B 157 | None | 0.78A | 1xf1B-5hz1B:undetectable | 1xf1B-5hz1B:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5igq | E3 UBIQUITIN-PROTEINLIGASE RFWD2 (Homo sapiens) |
PF00400(WD40) | 4 | LEU A 486GLY A 500ASN A 465ILE A 445 | None | 0.75A | 1xf1B-5igqA:undetectable | 1xf1B-5igqA:17.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ijb | TOLL-LIKE RECEPTOR4, VARIABLELYMPHOCYTE RECEPTORB CHIMERA (Eptatretusburgeri;Mus musculus) |
PF00560(LRR_1)PF11921(DUF3439)PF13855(LRR_8) | 4 | LEU A 356ASN A 407ILE A 363PHE A 365 | None | 0.85A | 1xf1B-5ijbA:undetectable | 1xf1B-5ijbA:20.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ip9 | DNA-DIRECTED RNAPOLYMERASE IISUBUNIT RPB1DNA-DIRECTED RNAPOLYMERASE IISUBUNIT RPB2 (Saccharomycescerevisiae;Saccharomycescerevisiae) |
PF00623(RNA_pol_Rpb1_2)PF04983(RNA_pol_Rpb1_3)PF04990(RNA_pol_Rpb1_7)PF04992(RNA_pol_Rpb1_6)PF04997(RNA_pol_Rpb1_1)PF04998(RNA_pol_Rpb1_5)PF05000(RNA_pol_Rpb1_4)PF00562(RNA_pol_Rpb2_6)PF04560(RNA_pol_Rpb2_7)PF04561(RNA_pol_Rpb2_2)PF04563(RNA_pol_Rpb2_1)PF04565(RNA_pol_Rpb2_3)PF04566(RNA_pol_Rpb2_4)PF04567(RNA_pol_Rpb2_5) | 4 | LEU B1026GLY A 665ASN A 742ILE B 827 | None | 0.90A | 1xf1B-5ip9B:undetectable | 1xf1B-5ip9B:22.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jbo | BETA-GLUCOSIDASE (Trichodermaharzianum) |
PF00232(Glyco_hydro_1) | 4 | LEU A 369HIS A 413ASN A 385ILE A 417 | None | 0.90A | 1xf1B-5jboA:undetectable | 1xf1B-5jboA:20.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kdr | ACETYL-COENZYME ACARBOXYLASE CARBOXYLTRANSFERASE SUBUNITALPHA (Staphylococcusaureus) |
PF03255(ACCA) | 4 | LEU A 202GLY A 203ASN A 177ILE A 206 | None | 0.87A | 1xf1B-5kdrA:2.4 | 1xf1B-5kdrA:17.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lkd | GLUTATHIONES-TRANSFERASEOMEGA-LIKE 2 (Saccharomycescerevisiae) |
PF13409(GST_N_2)PF13410(GST_C_2) | 4 | LEU A 61GLY A 60HIS A 194PHE A 189 | None | 0.89A | 1xf1B-5lkdA:undetectable | 1xf1B-5lkdA:18.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mif | 'CARBOXYL ESTERASE 2 (Tubermelanosporum) |
PF07859(Abhydrolase_3) | 4 | LEU A 325GLY A 318HIS A 317ILE A 316 | None | 0.85A | 1xf1B-5mifA:2.5 | 1xf1B-5mifA:17.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n5n | TUBULIN BETA CHAIN (Homo sapiens) |
no annotation | 4 | LEU B 153GLY B 150HIS B 139ILE B 7 | None | 0.85A | 1xf1B-5n5nB:2.6 | 1xf1B-5n5nB:17.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nny | WIPB (Legionellapneumophila) |
no annotation | 4 | GLY A 235HIS A 238ASN A 237ILE A 239 | None | 0.67A | 1xf1B-5nnyA:undetectable | 1xf1B-5nnyA:16.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o4m | HCGC (Methanococcusmaripaludis) |
PF06690(DUF1188) | 4 | LEU A 131GLY A 157ASN A 127PHE A 126 | None | 0.81A | 1xf1B-5o4mA:undetectable | 1xf1B-5o4mA:14.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w3f | TUBULIN ALPHA-1CHAIN (Saccharomycescerevisiae) |
PF00091(Tubulin)PF03953(Tubulin_C) | 4 | LEU A 154GLY A 151HIS A 140ILE A 7 | None | 0.89A | 1xf1B-5w3fA:undetectable | 1xf1B-5w3fA:18.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yl7 | PSEUDOALTEROMONASARCTICA PAMC 21717 (Pseudoalteromonasarctica) |
no annotation | 4 | LEU A 316GLY A 317ASN A 355ILE A 287 | None | 0.82A | 1xf1B-5yl7A:14.5 | 1xf1B-5yl7A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bdc | HCP1 (Flavobacteriumjohnsoniae) |
no annotation | 4 | LEU A 23GLY A 39ASN A 125ILE A 116 | None | 0.70A | 1xf1B-6bdcA:undetectable | 1xf1B-6bdcA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gdg | TRXA,ADENOSINERECEPTOR A2A (Escherichiacoli;Homo sapiens) |
no annotation | 4 | HIS A 250ASN A 253ILE A 251PHE A 255 | NEC A 400 (-4.5A)NEC A 400 (-3.5A)NoneNone | 0.87A | 1xf1B-6gdgA:undetectable | 1xf1B-6gdgA:undetectable |