SIMILAR PATTERNS OF AMINO ACIDS FOR 1XF1_B_ACTB1108_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ahi 7
ALPHA-HYDROXYSTEROID
DEHYDROGENASE


(Escherichia
coli)
PF13561
(adh_short_C2)
4 GLY A  97
ASN A 118
ILE A  69
PHE A 122
NAI  A 302 (-3.5A)
None
NAI  A 302 (-3.8A)
None
0.85A 1xf1B-1ahiA:
1.9
1xf1B-1ahiA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bvo TRANSCRIPTION FACTOR
GAMBIF1


(Anopheles
gambiae)
PF00554
(RHD_DNA_bind)
4 GLY A 148
ASN A 146
ILE A  75
PHE A 144
None
0.82A 1xf1B-1bvoA:
2.7
1xf1B-1bvoA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1exf EXFOLIATVE TOXIN A

(Staphylococcus
aureus)
PF13365
(Trypsin_2)
4 LEU A 181
GLY A 228
HIS A 213
ILE A 199
None
0.80A 1xf1B-1exfA:
undetectable
1xf1B-1exfA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hds HEMOGLOBIN S (DEOXY)
(ALPHA CHAIN)


(Odocoileus
virginianus)
PF00042
(Globin)
4 LEU A 109
HIS A 122
ASN A 126
PHE A 128
None
0.81A 1xf1B-1hdsA:
undetectable
1xf1B-1hdsA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i5e URACIL
PHOSPHORIBOSYLTRANSF
ERASE


([Bacillus]
caldolyticus)
PF14681
(UPRTase)
4 LEU A 118
GLY A  98
HIS A  99
ILE A 100
None
0.87A 1xf1B-1i5eA:
2.3
1xf1B-1i5eA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ihp PHYTASE

(Aspergillus
ficuum)
PF00328
(His_Phos_2)
4 LEU A 113
GLY A  60
HIS A  59
PHE A  31
None
0.90A 1xf1B-1ihpA:
undetectable
1xf1B-1ihpA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE


(Sulfolobus
acidocaldarius)
PF00128
(Alpha-amylase)
PF09196
(DUF1953)
4 GLY A 232
HIS A 229
ASN A  89
ILE A 230
None
0.89A 1xf1B-1iv8A:
2.1
1xf1B-1iv8A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1


(Paracoccus
denitrificans)
PF01011
(PQQ)
PF13360
(PQQ_2)
4 LEU A 158
GLY A 131
HIS A 132
ILE A 133
None
0.74A 1xf1B-1lrwA:
undetectable
1xf1B-1lrwA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n47 ISOLECTIN B4

(Vicia villosa)
PF00139
(Lectin_legB)
4 LEU A 105
GLY A 103
ASN A 129
ILE A 145
None
TNR  A1401 (-3.4A)
TNR  A1401 ( 3.1A)
None
0.86A 1xf1B-1n47A:
undetectable
1xf1B-1n47A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nb2 NUCLEOSIDE
DIPHOSPHATE KINASE


(Virgibacillus
halodenitrificans)
PF00334
(NDK)
4 LEU A  89
GLY A 117
HIS A 116
ILE A 115
None
0.89A 1xf1B-1nb2A:
undetectable
1xf1B-1nb2A:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5o URACIL
PHOSPHORIBOSYLTRANSF
ERASE


(Thermotoga
maritima)
PF14681
(UPRTase)
4 LEU A 118
GLY A  98
HIS A  99
ILE A 100
None
0.78A 1xf1B-1o5oA:
2.7
1xf1B-1o5oA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qmo MANNOSE BINDING
LECTIN, FRIL
MANNOSE BINDING
LECTIN, FRIL


(Lablab
purpureus;
Lablab
purpureus)
PF00139
(Lectin_legB)
PF00139
(Lectin_legB)
4 LEU A 106
GLY A 104
ASN E 144
ILE E 162
None
MAN  A 302 (-3.7A)
MAN  A 302 ( 3.0A)
None
0.89A 1xf1B-1qmoA:
undetectable
1xf1B-1qmoA:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qoz ACETYL XYLAN
ESTERASE


(Trichoderma
reesei)
PF01083
(Cutinase)
4 LEU A 140
GLY A 139
HIS A 138
ILE A 137
None
0.79A 1xf1B-1qozA:
1.9
1xf1B-1qozA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ska 3-PHYTASE A

(Aspergillus
fumigatus)
PF00328
(His_Phos_2)
4 LEU A 113
GLY A  60
HIS A  59
PHE A  31
None
0.89A 1xf1B-1skaA:
undetectable
1xf1B-1skaA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t90 PROBABLE
METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE


(Bacillus
subtilis)
PF00171
(Aldedh)
4 LEU A 216
GLY A 240
ILE A 224
PHE A 226
None
None
None
NAD  A1490 (-4.7A)
0.89A 1xf1B-1t90A:
undetectable
1xf1B-1t90A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9s URACIL
PHOSPHORIBOSYLTRANSF
ERASE


(Thermus
thermophilus)
PF14681
(UPRTase)
4 LEU A 117
GLY A  97
HIS A  98
ILE A  99
None
0.71A 1xf1B-1v9sA:
2.7
1xf1B-1v9sA:
13.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xf1 C5A PEPTIDASE

(Streptococcus
pyogenes)
PF00082
(Peptidase_S8)
PF02225
(PA)
PF06280
(fn3_5)
PF13585
(CHU_C)
6 LEU A 479
GLY A 483
HIS A 598
ASN A 600
ILE A 707
PHE A 709
CIT  A1101 (-3.7A)
ACT  A1107 (-3.8A)
None
ACT  A1107 (-4.1A)
ACT  A1107 (-3.8A)
None
0.13A 1xf1B-1xf1A:
57.6
1xf1B-1xf1A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xzq PROBABLE TRNA
MODIFICATION GTPASE
TRME


(Thermotoga
maritima)
PF10396
(TrmE_N)
4 LEU B  34
GLY B  48
HIS B  47
ILE B  46
None
None
FON  A 451 (-3.9A)
None
0.87A 1xf1B-1xzqB:
undetectable
1xf1B-1xzqB:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3w ALPHA-AMYLASE G-6

(Bacillus
halodurans)
PF03423
(CBM_25)
4 GLY A  39
HIS A  24
ASN A  68
ILE A  25
None
GLC  A1107 ( 4.4A)
None
None
0.86A 1xf1B-2c3wA:
undetectable
1xf1B-2c3wA:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7j SEP-TRNA:CYS-TRNA
SYNTHASE


(Archaeoglobus
fulgidus)
PF05889
(SepSecS)
4 GLY A 335
HIS A 334
ASN A  11
ILE A 333
None
0.76A 1xf1B-2e7jA:
2.0
1xf1B-2e7jA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2igt SAM DEPENDENT
METHYLTRANSFERASE


(Agrobacterium
fabrum)
PF10672
(Methyltrans_SAM)
5 LEU A 148
GLY A 144
HIS A 159
ASN A 138
ILE A 184
None
1.18A 1xf1B-2igtA:
undetectable
1xf1B-2igtA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j2m CATALASE

(Exiguobacterium
oxidotolerans)
PF00199
(Catalase)
PF06628
(Catalase-rel)
4 LEU A 413
GLY A 411
HIS A 410
ILE A 409
None
0.82A 1xf1B-2j2mA:
undetectable
1xf1B-2j2mA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j76 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4B


(Homo sapiens)
PF00076
(RRM_1)
4 LEU E   5
GLY E  45
ILE E  17
PHE E  49
None
0.83A 1xf1B-2j76E:
undetectable
1xf1B-2j76E:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m9n FANCONI
ANEMIA-ASSOCIATED
PROTEIN OF 24 KDA


(Homo sapiens)
PF12826
(HHH_2)
4 LEU A 195
HIS A 208
ASN A 189
ILE A 207
None
0.90A 1xf1B-2m9nA:
undetectable
1xf1B-2m9nA:
5.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rf4 DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA4


(Saccharomyces
cerevisiae)
PF03876
(SHS2_Rpb7-N)
4 LEU A 147
GLY A 146
HIS A 144
ILE A 157
None
0.83A 1xf1B-2rf4A:
undetectable
1xf1B-2rf4A:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2riu 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE


(Candida
albicans)
PF00926
(DHBP_synthase)
4 GLY A 100
HIS A 128
ILE A 129
PHE A  93
None
0.80A 1xf1B-2riuA:
undetectable
1xf1B-2riuA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w5o ALPHA-L-ARABINOFURAN
OSIDASE


(Fusarium
graminearum)
no annotation 4 LEU A 104
GLY A  57
ILE A  73
PHE A  71
None
0.87A 1xf1B-2w5oA:
undetectable
1xf1B-2w5oA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wpg AMYLOSUCRASE OR
ALPHA AMYLASE


(Xanthomonas
campestris)
PF00128
(Alpha-amylase)
PF11941
(DUF3459)
5 LEU A 453
GLY A 448
HIS A 519
ASN A 447
ILE A 395
None
1.32A 1xf1B-2wpgA:
undetectable
1xf1B-2wpgA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjv REGULATOR OF
RIBONUCLEASE
ACTIVITY A


(Escherichia
coli)
PF03737
(RraA-like)
4 LEU A 153
HIS A 143
ILE A  36
PHE A 139
None
0.82A 1xf1B-2yjvA:
2.9
1xf1B-2yjvA:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3au9 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE


(Plasmodium
falciparum)
PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C)
4 LEU A 187
HIS A 471
ASN A 420
ILE A 467
None
0.90A 1xf1B-3au9A:
undetectable
1xf1B-3au9A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cy5 HEMOGLOBIN SUBUNIT
BETA


(Bubalus bubalis)
PF00042
(Globin)
4 LEU B  81
HIS B  77
ASN B  73
PHE B  71
None
None
None
HEM  B 147 ( 4.6A)
0.67A 1xf1B-3cy5B:
undetectable
1xf1B-3cy5B:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cze SUCROSE HYDROLASE

(Xanthomonas
citri)
PF00128
(Alpha-amylase)
5 LEU A 452
GLY A 447
HIS A 518
ASN A 446
ILE A 394
None
1.35A 1xf1B-3czeA:
undetectable
1xf1B-3czeA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3k ENHANCER OF
MRNA-DECAPPING
PROTEIN 3


(Homo sapiens)
PF03853
(YjeF_N)
4 LEU A 368
GLY A 342
HIS A 344
ILE A 378
None
0.86A 1xf1B-3d3kA:
undetectable
1xf1B-3d3kA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d54 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE 1


(Thermotoga
maritima)
PF13507
(GATase_5)
4 LEU D  92
ASN D 175
ILE D  82
PHE D 181
None
0.81A 1xf1B-3d54D:
2.0
1xf1B-3d54D:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmp URACIL
PHOSPHORIBOSYLTRANSF
ERASE


(Burkholderia
pseudomallei)
PF14681
(UPRTase)
4 LEU A 123
GLY A 104
HIS A 105
ILE A 106
None
0.82A 1xf1B-3dmpA:
undetectable
1xf1B-3dmpA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3doh ESTERASE

(Thermotoga
maritima)
PF02230
(Abhydrolase_2)
4 LEU A  53
GLY A  50
ILE A  48
PHE A 134
None
0.79A 1xf1B-3dohA:
2.1
1xf1B-3dohA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpl NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE


(Clostridium
beijerinckii;
Thermoanaerobacter
brockii)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
4 LEU A 351
GLY A 326
HIS A 329
ILE A 330
None
0.81A 1xf1B-3fplA:
3.8
1xf1B-3fplA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwb PEPTIDASE M16
INACTIVE DOMAIN
FAMILY PROTEIN


(Pseudomonas
protegens)
PF05193
(Peptidase_M16_C)
4 LEU A 285
GLY A 277
ASN A 273
ILE A 314
None
0.78A 1xf1B-3gwbA:
undetectable
1xf1B-3gwbA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gz5 MUTT/NUDIX FAMILY
PROTEIN


(Shewanella
oneidensis)
PF00293
(NUDIX)
4 LEU A  38
GLY A  51
HIS A 142
ILE A 146
None
0.74A 1xf1B-3gz5A:
undetectable
1xf1B-3gz5A:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gz8 MUTT/NUDIX FAMILY
PROTEIN


(Shewanella
oneidensis)
PF00293
(NUDIX)
4 LEU A  38
GLY A  51
HIS A 142
ILE A 146
None
None
APR  A 302 (-4.0A)
None
0.75A 1xf1B-3gz8A:
undetectable
1xf1B-3gz8A:
11.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdi PROCESSING PROTEASE

(Bacillus
halodurans)
PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
4 LEU A 269
GLY A 262
ASN A 258
ILE A 298
None
0.82A 1xf1B-3hdiA:
undetectable
1xf1B-3hdiA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3htn PUTATIVE DNA BINDING
PROTEIN


(Bacteroides
thetaiotaomicron)
PF03479
(DUF296)
4 LEU A 132
GLY A 119
ASN A  83
PHE A 159
None
0.81A 1xf1B-3htnA:
undetectable
1xf1B-3htnA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j0a TOLL-LIKE RECEPTOR 5

(Homo sapiens)
PF01582
(TIR)
PF13855
(LRR_8)
4 LEU A 285
GLY A 284
ASN A 248
PHE A 246
None
0.81A 1xf1B-3j0aA:
undetectable
1xf1B-3j0aA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6d PUTATIVE
OXIDOREDUCTASE


(Pseudomonas
putida)
PF03446
(NAD_binding_2)
4 LEU A  92
GLY A 120
HIS A 121
ILE A  97
None
0.90A 1xf1B-3l6dA:
undetectable
1xf1B-3l6dA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l88 FIBER PROTEIN

(Human
mastadenovirus
B)
PF00541
(Adeno_knob)
4 LEU A 174
GLY A 176
ASN A 182
ILE A 146
None
0.86A 1xf1B-3l88A:
undetectable
1xf1B-3l88A:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lfu DNA HELICASE II

(Escherichia
coli)
PF00580
(UvrD-helicase)
PF13361
(UvrD_C)
4 LEU A 559
GLY A 602
ILE A 572
PHE A 632
None
0.86A 1xf1B-3lfuA:
undetectable
1xf1B-3lfuA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lyx SENSORY BOX/GGDEF
DOMAIN PROTEIN


(Colwellia
psychrerythraea)
PF08447
(PAS_3)
4 LEU A 112
GLY A 113
ASN A 115
ILE A  20
None
0.89A 1xf1B-3lyxA:
undetectable
1xf1B-3lyxA:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6u LYSR TYPE REGULATOR
OF TSAMBCD


(Comamonas
testosteroni)
PF03466
(LysR_substrate)
4 GLY A  92
HIS A  93
ILE A  94
PHE A 118
None
0.90A 1xf1B-3n6uA:
undetectable
1xf1B-3n6uA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pps LACCASE

(Thielavia
arenaria)
PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3)
4 LEU A  98
GLY A  97
HIS A  96
ILE A 154
None
None
CU  A 603 ( 3.1A)
None
0.78A 1xf1B-3ppsA:
undetectable
1xf1B-3ppsA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pv6 IG-LIKE
DOMAIN-CONTAINING
PROTEIN
DKFZP686O24166/DKFZP
686I21167


(Homo sapiens)
PF07654
(C1-set)
4 LEU A  56
GLY A 103
ASN A  49
PHE A  51
None
0.70A 1xf1B-3pv6A:
3.0
1xf1B-3pv6A:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qsg NAD-BINDING
PHOSPHOGLUCONATE
DEHYDROGENASE-LIKE
PROTEIN


(Alicyclobacillus
acidocaldarius)
PF03807
(F420_oxidored)
PF09130
(DUF1932)
4 LEU A  83
GLY A  80
HIS A 110
ILE A 107
None
0.85A 1xf1B-3qsgA:
undetectable
1xf1B-3qsgA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubd RIBOSOMAL PROTEIN S6
KINASE ALPHA-3


(Mus musculus)
PF00069
(Pkinase)
4 LEU A 201
GLY A 205
HIS A 206
ILE A 207
None
0.89A 1xf1B-3ubdA:
undetectable
1xf1B-3ubdA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujq LEGUME LECTIN

(Lablab
purpureus)
PF00139
(Lectin_legB)
4 LEU A 128
GLY A 126
ASN A 152
ILE A 169
None
GAL  A 301 ( 3.4A)
CA  A 303 (-3.6A)
None
0.90A 1xf1B-3ujqA:
undetectable
1xf1B-3ujqA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpq GLUTATHIONE
S-TRANSFERASE SIGMA


(Bombyx mori)
PF02798
(GST_N)
PF14497
(GST_C_3)
4 LEU A 137
GLY A 142
HIS A 143
ILE A 144
None
PGO  A 311 (-3.2A)
PGO  A 311 ( 4.1A)
None
0.85A 1xf1B-3vpqA:
undetectable
1xf1B-3vpqA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ap3 STEROID
MONOOXYGENASE


(Rhodococcus
rhodochrous)
PF00743
(FMO-like)
4 LEU A 469
GLY A 476
ILE A 546
PHE A 544
None
0.83A 1xf1B-4ap3A:
undetectable
1xf1B-4ap3A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c25 L-FUCULOSE PHOSPHATE
ALDOLASE


(Streptococcus
pneumoniae)
PF00596
(Aldolase_II)
4 LEU A  15
HIS A  93
ASN A  27
ILE A  92
None
ZN  A 301 ( 3.2A)
SO4  A 304 ( 3.8A)
None
0.85A 1xf1B-4c25A:
undetectable
1xf1B-4c25A:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3h DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA43


(Saccharomyces
cerevisiae)
PF03876
(SHS2_Rpb7-N)
4 LEU G 147
GLY G 146
HIS G 144
ILE G 157
None
0.78A 1xf1B-4c3hG:
undetectable
1xf1B-4c3hG:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c82 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE


(Plasmodium
falciparum)
PF02542
(YgbB)
4 LEU A 100
GLY A 118
HIS A  73
ILE A 227
None
None
ZN  A1240 (-3.2A)
None
0.90A 1xf1B-4c82A:
undetectable
1xf1B-4c82A:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cv7 VIRULENCE ASSOCIATED
PROTEIN VAPB


(Rhodococcus
hoagii)
PF05526
(R_equi_Vir)
5 GLY A 171
HIS A 172
ASN A 161
ILE A 173
PHE A 149
None
1.45A 1xf1B-4cv7A:
undetectable
1xf1B-4cv7A:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjh PHOSPHOMANNOMUTASE

(Brucella
melitensis)
PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III)
4 LEU A  82
GLY A  80
ASN A  78
PHE A  49
None
0.79A 1xf1B-4hjhA:
2.3
1xf1B-4hjhA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i0n NECROTIC ENTERITIS
TOXIN B


(Clostridium
perfringens)
PF07968
(Leukocidin)
4 LEU A  91
GLY A  76
ILE A 311
PHE A 309
None
0.90A 1xf1B-4i0nA:
3.0
1xf1B-4i0nA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k9d GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE


(Brugia malayi)
PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C)
4 LEU A 254
GLY A 174
HIS A 170
ILE A 169
None
0.69A 1xf1B-4k9dA:
undetectable
1xf1B-4k9dA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lob POLYPRENYL
SYNTHETASE


(Acinetobacter
baumannii)
PF00348
(polyprenyl_synt)
4 GLY A 204
HIS A 205
ASN A 208
PHE A 210
GOL  A 401 ( 3.8A)
GOL  A 401 (-3.4A)
GOL  A 401 (-3.8A)
None
0.83A 1xf1B-4lobA:
undetectable
1xf1B-4lobA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lsm GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE,
CYTOSOLIC


(Trypanosoma
cruzi)
PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C)
4 LEU A 253
GLY A 173
HIS A 169
ILE A 168
None
0.71A 1xf1B-4lsmA:
undetectable
1xf1B-4lsmA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2


(Arabidopsis
thaliana)
PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8)
4 LEU A 734
GLY A 712
HIS A 688
ILE A 689
None
0.80A 1xf1B-4mn8A:
undetectable
1xf1B-4mn8A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2


(Arabidopsis
thaliana)
PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8)
4 LEU A 734
GLY A 712
HIS A 688
ILE A 689
None
0.82A 1xf1B-4mnaA:
undetectable
1xf1B-4mnaA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o59 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE


(Bos taurus)
PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C)
4 LEU O 246
GLY O 166
HIS O 162
ILE O 161
None
0.66A 1xf1B-4o59O:
undetectable
1xf1B-4o59O:
16.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p42 EXTENDED
SYNAPTOTAGMIN-2


(Homo sapiens)
PF00168
(C2)
PF17047
(SMP_LBD)
4 GLY A 314
HIS A 203
ASN A 201
PHE A 207
None
0.83A 1xf1B-4p42A:
undetectable
1xf1B-4p42A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4paf TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE


(Ruegeria
pomeroyi)
PF03480
(DctP)
4 LEU A 169
ASN A 182
ILE A 171
PHE A 180
None
0.87A 1xf1B-4pafA:
undetectable
1xf1B-4pafA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q8h PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2


(Saccharomyces
cerevisiae)
PF00929
(RNase_T)
PF13423
(UCH_1)
4 GLY A 506
ASN A 500
ILE A 564
PHE A 499
None
0.89A 1xf1B-4q8hA:
undetectable
1xf1B-4q8hA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uur PUTATIVE
HEMOGLOBIN-LIKE
OXYGEN-BINDING
PROTEIN


(Pseudoalteromonas
haloplanktis)
PF01152
(Bac_globin)
4 LEU A  73
ASN A  39
ILE A  37
PHE A  41
None
0.90A 1xf1B-4uurA:
undetectable
1xf1B-4uurA:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v39 SIALYLTRANSFERASE

(Pasteurella
dagmatis)
PF11477
(PM0188)
4 LEU A   5
HIS A   7
ASN A  58
ILE A  55
None
0.86A 1xf1B-4v39A:
undetectable
1xf1B-4v39A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjs RSA4

(Chaetomium
thermophilum)
PF00400
(WD40)
5 LEU A 400
GLY A 436
ASN A 432
ILE A 419
PHE A 438
None
1.44A 1xf1B-4wjsA:
undetectable
1xf1B-4wjsA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wu0 SIMILAR TO YTER
(BACILUS SUBTILIS)


(Clostridium
acetobutylicum)
PF07470
(Glyco_hydro_88)
4 LEU A 132
GLY A 131
HIS A 119
ILE A 127
None
0.75A 1xf1B-4wu0A:
undetectable
1xf1B-4wu0A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhp PARM HYBRID FUSION
PROTEIN


(Bacillus
thuringiensis)
no annotation 4 LEU A  27
GLY A  31
ASN A 215
ILE A 213
None
0.75A 1xf1B-4xhpA:
2.9
1xf1B-4xhpA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhp PARM HYBRID FUSION
PROTEIN


(Bacillus
thuringiensis)
no annotation 4 LEU A 470
GLY A 474
ASN A 658
ILE A 656
None
0.85A 1xf1B-4xhpA:
2.9
1xf1B-4xhpA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysl BETA-LACTAMASE
DOMAIN PROTEIN


(Pseudomonas
putida)
PF00753
(Lactamase_B)
4 LEU A 172
GLY A 178
HIS A 236
ILE A 237
None
0.88A 1xf1B-4yslA:
undetectable
1xf1B-4yslA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bo6 SIA-ALPHA-2,3-GAL-BE
TA-1,4-GLCNAC-R:ALPH
A
2,8-SIALYLTRANSFERAS
E


(Homo sapiens)
PF00777
(Glyco_transf_29)
4 LEU A 260
ASN A 211
ILE A 245
PHE A 191
None
0.87A 1xf1B-5bo6A:
undetectable
1xf1B-5bo6A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c7i GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
TESTIS-SPECIFIC


(Mus musculus)
PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C)
4 LEU O 353
GLY O 273
HIS O 269
ILE O 268
None
0.67A 1xf1B-5c7iO:
2.5
1xf1B-5c7iO:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c7o GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
TESTIS-SPECIFIC


(Homo sapiens)
PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C)
4 LEU O 321
GLY O 241
HIS O 237
ILE O 236
None
0.67A 1xf1B-5c7oO:
2.3
1xf1B-5c7oO:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5doi TELOMERASE-ASSOCIATE
D PROTEIN 19


(Tetrahymena
thermophila)
no annotation 4 LEU A  56
HIS A 134
ASN A 133
ILE A 136
None
0.78A 1xf1B-5doiA:
undetectable
1xf1B-5doiA:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6s INTEGRIN ALPHA-L

(Homo sapiens)
PF00092
(VWA)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2)
4 LEU A 503
GLY A 562
HIS A 561
ILE A 560
None
0.73A 1xf1B-5e6sA:
2.8
1xf1B-5e6sA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fa1 PUTATIVE N-ACETYL
GLUCOSAMINYL
TRANSFERASE


(Raoultella
terrigena)
PF05159
(Capsule_synth)
4 LEU A 392
ASN A 335
ILE A 396
PHE A 339
None
0.90A 1xf1B-5fa1A:
undetectable
1xf1B-5fa1A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fgu GREEN FLUORESCENT
PROTEIN,EXTRACELLULA
R STREPTODORNASE D


(Streptococcus
pyogenes;
Aequorea
victoria)
PF01353
(GFP)
PF13930
(Endonuclea_NS_2)
4 LEU A1189
GLY A1188
ASN A1211
ILE A1204
None
SO4  A1403 (-3.7A)
SO4  A1403 (-3.2A)
None
0.77A 1xf1B-5fguA:
undetectable
1xf1B-5fguA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fgw EXTRACELLULAR
STREPTODORNASE D


(Streptococcus
pyogenes)
PF01223
(Endonuclease_NS)
4 LEU A 189
GLY A 188
ASN A 211
ILE A 204
None
ZN  A 302 ( 4.5A)
ZN  A 302 (-2.8A)
None
0.87A 1xf1B-5fgwA:
undetectable
1xf1B-5fgwA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hz1 PROBABLE LRR
RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE
AT4G26540


(Arabidopsis
thaliana)
PF13855
(LRR_8)
4 LEU B 202
GLY B 179
HIS B 156
ILE B 157
None
0.78A 1xf1B-5hz1B:
undetectable
1xf1B-5hz1B:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5igq E3 UBIQUITIN-PROTEIN
LIGASE RFWD2


(Homo sapiens)
PF00400
(WD40)
4 LEU A 486
GLY A 500
ASN A 465
ILE A 445
None
0.75A 1xf1B-5igqA:
undetectable
1xf1B-5igqA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijb TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA


(Eptatretus
burgeri;
Mus musculus)
PF00560
(LRR_1)
PF11921
(DUF3439)
PF13855
(LRR_8)
4 LEU A 356
ASN A 407
ILE A 363
PHE A 365
None
0.85A 1xf1B-5ijbA:
undetectable
1xf1B-5ijbA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2


(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae)
PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
4 LEU B1026
GLY A 665
ASN A 742
ILE B 827
None
0.90A 1xf1B-5ip9B:
undetectable
1xf1B-5ip9B:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbo BETA-GLUCOSIDASE

(Trichoderma
harzianum)
PF00232
(Glyco_hydro_1)
4 LEU A 369
HIS A 413
ASN A 385
ILE A 417
None
0.90A 1xf1B-5jboA:
undetectable
1xf1B-5jboA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdr ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
ALPHA


(Staphylococcus
aureus)
PF03255
(ACCA)
4 LEU A 202
GLY A 203
ASN A 177
ILE A 206
None
0.87A 1xf1B-5kdrA:
2.4
1xf1B-5kdrA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lkd GLUTATHIONE
S-TRANSFERASE
OMEGA-LIKE 2


(Saccharomyces
cerevisiae)
PF13409
(GST_N_2)
PF13410
(GST_C_2)
4 LEU A  61
GLY A  60
HIS A 194
PHE A 189
None
0.89A 1xf1B-5lkdA:
undetectable
1xf1B-5lkdA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mif 'CARBOXYL ESTERASE 2

(Tuber
melanosporum)
PF07859
(Abhydrolase_3)
4 LEU A 325
GLY A 318
HIS A 317
ILE A 316
None
0.85A 1xf1B-5mifA:
2.5
1xf1B-5mifA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n5n TUBULIN BETA CHAIN

(Homo sapiens)
no annotation 4 LEU B 153
GLY B 150
HIS B 139
ILE B   7
None
0.85A 1xf1B-5n5nB:
2.6
1xf1B-5n5nB:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nny WIPB

(Legionella
pneumophila)
no annotation 4 GLY A 235
HIS A 238
ASN A 237
ILE A 239
None
0.67A 1xf1B-5nnyA:
undetectable
1xf1B-5nnyA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o4m HCGC

(Methanococcus
maripaludis)
PF06690
(DUF1188)
4 LEU A 131
GLY A 157
ASN A 127
PHE A 126
None
0.81A 1xf1B-5o4mA:
undetectable
1xf1B-5o4mA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3f TUBULIN ALPHA-1
CHAIN


(Saccharomyces
cerevisiae)
PF00091
(Tubulin)
PF03953
(Tubulin_C)
4 LEU A 154
GLY A 151
HIS A 140
ILE A   7
None
0.89A 1xf1B-5w3fA:
undetectable
1xf1B-5w3fA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yl7 PSEUDOALTEROMONAS
ARCTICA PAMC 21717


(Pseudoalteromonas
arctica)
no annotation 4 LEU A 316
GLY A 317
ASN A 355
ILE A 287
None
0.82A 1xf1B-5yl7A:
14.5
1xf1B-5yl7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bdc HCP1

(Flavobacterium
johnsoniae)
no annotation 4 LEU A  23
GLY A  39
ASN A 125
ILE A 116
None
0.70A 1xf1B-6bdcA:
undetectable
1xf1B-6bdcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gdg TRXA,ADENOSINE
RECEPTOR A2A


(Escherichia
coli;
Homo sapiens)
no annotation 4 HIS A 250
ASN A 253
ILE A 251
PHE A 255
NEC  A 400 (-4.5A)
NEC  A 400 (-3.5A)
None
None
0.87A 1xf1B-6gdgA:
undetectable
1xf1B-6gdgA:
undetectable