SIMILAR PATTERNS OF AMINO ACIDS FOR 1XF1_A_ACTA1107_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c0i D-AMINO ACID OXIDASE

(Rhodotorula
toruloides) 		PF01266
(DAO) 		4 LEU A1103
GLY A1102
ILE A1128
PHE A1096
 None
 0.99A 1xf1A-1c0iA:
undetectable		 1xf1A-1c0iA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fot CAMP-DEPENDENT
PROTEIN KINASE TYPE
1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 LEU A 218
GLY A 222
HIS A 223
ILE A 224
 None
 0.88A 1xf1A-1fotA:
undetectable		 1xf1A-1fotA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g67 THIAMIN PHOSPHATE
SYNTHASE

(Bacillus
subtilis) 		PF02581
(TMP-TENI) 		4 LEU A 127
GLY A 128
HIS A 107
ILE A 108
 None
None
ICP  A2001 ( 3.5A)
None
 0.93A 1xf1A-1g67A:
3.0		 1xf1A-1g67A:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i5e URACIL
PHOSPHORIBOSYLTRANSF
ERASE

([Bacillus]
caldolyticus) 		PF14681
(UPRTase) 		4 LEU A 118
GLY A  98
HIS A  99
ILE A 100
 None
 0.87A 1xf1A-1i5eA:
undetectable		 1xf1A-1i5eA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ihp PHYTASE

(Aspergillus
ficuum) 		PF00328
(His_Phos_2) 		4 LEU A 113
GLY A  60
HIS A  59
PHE A  31
 None
 0.92A 1xf1A-1ihpA:
undetectable		 1xf1A-1ihpA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k2p TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 402
GLY A 419
ILE A 473
PHE A 471
 None
 0.91A 1xf1A-1k2pA:
undetectable		 1xf1A-1k2pA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1

(Paracoccus
denitrificans) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		4 LEU A 158
GLY A 131
HIS A 132
ILE A 133
 None
 0.72A 1xf1A-1lrwA:
undetectable		 1xf1A-1lrwA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mf1 ADENYLOSUCCINATE
SYNTHETASE

(Mus musculus) 		PF00709
(Adenylsucc_synt) 		4 LEU A 109
GLY A 108
HIS A 105
ILE A 104
 None
 0.98A 1xf1A-1mf1A:
undetectable		 1xf1A-1mf1A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nb2 NUCLEOSIDE
DIPHOSPHATE KINASE

(Virgibacillus
halodenitrificans) 		PF00334
(NDK) 		4 LEU A  89
GLY A 117
HIS A 116
ILE A 115
 None
 0.89A 1xf1A-1nb2A:
undetectable		 1xf1A-1nb2A:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5o URACIL
PHOSPHORIBOSYLTRANSF
ERASE

(Thermotoga
maritima) 		PF14681
(UPRTase) 		4 LEU A 118
GLY A  98
HIS A  99
ILE A 100
 None
 0.80A 1xf1A-1o5oA:
2.4		 1xf1A-1o5oA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oa1 HYDROXYLAMINE
REDUCTASE

(Desulfovibrio
vulgaris) 		PF03063
(Prismane) 		4 LEU A  88
GLY A  87
ILE A  84
PHE A  36
 None
 0.88A 1xf1A-1oa1A:
undetectable		 1xf1A-1oa1A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qoz ACETYL XYLAN
ESTERASE

(Trichoderma
reesei) 		PF01083
(Cutinase) 		4 LEU A 140
GLY A 139
HIS A 138
ILE A 137
 None
 0.80A 1xf1A-1qozA:
3.3		 1xf1A-1qozA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ska 3-PHYTASE A

(Aspergillus
fumigatus) 		PF00328
(His_Phos_2) 		4 LEU A 113
GLY A  60
HIS A  59
PHE A  31
 None
 0.91A 1xf1A-1skaA:
undetectable		 1xf1A-1skaA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t90 PROBABLE
METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00171
(Aldedh) 		4 LEU A 216
GLY A 240
ILE A 224
PHE A 226
 None
None
None
NAD  A1490 (-4.7A)
 0.85A 1xf1A-1t90A:
undetectable		 1xf1A-1t90A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9s URACIL
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus) 		PF14681
(UPRTase) 		4 LEU A 117
GLY A  97
HIS A  98
ILE A  99
 None
 0.72A 1xf1A-1v9sA:
2.2		 1xf1A-1v9sA:
13.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xf1 C5A PEPTIDASE

(Streptococcus
pyogenes) 		PF00082
(Peptidase_S8)
PF02225
(PA)
PF06280
(fn3_5)
PF13585
(CHU_C) 		5 LEU A 479
GLY A 483
HIS A 598
ILE A 707
PHE A 709
 CIT  A1101 (-3.7A)
ACT  A1107 (-3.8A)
None
ACT  A1107 (-3.8A)
None
 0.00A 1xf1A-1xf1A:
70.6		 1xf1A-1xf1A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xzq PROBABLE TRNA
MODIFICATION GTPASE
TRME

(Thermotoga
maritima) 		PF10396
(TrmE_N) 		4 LEU B  34
GLY B  48
HIS B  47
ILE B  46
 None
None
FON  A 451 (-3.9A)
None
 0.91A 1xf1A-1xzqB:
undetectable		 1xf1A-1xzqB:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yir NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE 2

(Pseudomonas
aeruginosa) 		PF04095
(NAPRTase) 		4 LEU A 324
HIS A 347
ILE A 344
PHE A 342
 None
 0.94A 1xf1A-1yirA:
1.6		 1xf1A-1yirA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z14 VP2

(Rodent
protoparvovirus
1) 		PF00740
(Parvo_coat) 		4 LEU A 429
HIS A 442
ILE A 435
PHE A 447
 None
 0.98A 1xf1A-1z14A:
undetectable		 1xf1A-1z14A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d42 NON-TOXIC CRYSTAL
PROTEIN

(Bacillus
thuringiensis) 		PF03318
(ETX_MTX2) 		4 LEU A  41
GLY A  40
ILE A  38
PHE A 223
 None
 0.89A 1xf1A-2d42A:
undetectable		 1xf1A-2d42A:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0q THIOREDOXIN

(Sulfurisphaera
tokodaii) 		PF00085
(Thioredoxin) 		4 GLY A  85
HIS A  52
ILE A  54
PHE A 112
 None
 0.95A 1xf1A-2e0qA:
undetectable		 1xf1A-2e0qA:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e1b 216AA LONG
HYPOTHETICAL
ALANYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF01411
(tRNA-synt_2c)
PF07973
(tRNA_SAD) 		4 LEU A 215
GLY A 194
HIS A 195
ILE A 196
 None
 0.95A 1xf1A-2e1bA:
undetectable		 1xf1A-2e1bA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g2c PUTATIVE MOLYBDENUM
COFACTOR
BIOSYNTHESIS PROTEIN

(Corynebacterium
diphtheriae) 		PF00994
(MoCF_biosynth) 		4 GLY A 125
HIS A  93
ILE A  92
PHE A  91
 None
 0.92A 1xf1A-2g2cA:
4.4		 1xf1A-2g2cA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0e PROTEIN KINASE
C-BETA II

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 LEU A 474
GLY A 478
HIS A 479
ILE A 480
 None
 0.90A 1xf1A-2i0eA:
undetectable		 1xf1A-2i0eA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7x PROTEIN CFT2

(Saccharomyces
cerevisiae) 		PF16661
(Lactamase_B_6) 		4 LEU A 290
GLY A 287
ILE A 323
PHE A 341
 None
 0.95A 1xf1A-2i7xA:
undetectable		 1xf1A-2i7xA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j2m CATALASE

(Exiguobacterium
oxidotolerans) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 LEU A 413
GLY A 411
HIS A 410
ILE A 409
 None
 0.82A 1xf1A-2j2mA:
undetectable		 1xf1A-2j2mA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j76 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4B

(Homo sapiens) 		PF00076
(RRM_1) 		4 LEU E   5
GLY E  45
ILE E  17
PHE E  49
 None
 0.81A 1xf1A-2j76E:
undetectable		 1xf1A-2j76E:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nx2 HYPOTHETICAL PROTEIN
YPSA

(Bacillus
subtilis) 		PF06908
(DUF1273) 		4 LEU A 133
GLY A 132
ILE A 127
PHE A 126
 None
 0.96A 1xf1A-2nx2A:
undetectable		 1xf1A-2nx2A:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rf4 DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA4

(Saccharomyces
cerevisiae) 		PF03876
(SHS2_Rpb7-N) 		4 LEU A 147
GLY A 146
HIS A 144
ILE A 157
 None
 0.81A 1xf1A-2rf4A:
undetectable		 1xf1A-2rf4A:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2riu 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE

(Candida
albicans) 		PF00926
(DHBP_synthase) 		4 GLY A 100
HIS A 128
ILE A 129
PHE A  93
 None
 0.80A 1xf1A-2riuA:
undetectable		 1xf1A-2riuA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd5 DMPK PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 203
GLY A 207
HIS A 208
ILE A 209
 None
 0.92A 1xf1A-2vd5A:
undetectable		 1xf1A-2vd5A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w5o ALPHA-L-ARABINOFURAN
OSIDASE

(Fusarium
graminearum) 		no annotation 4 LEU A 104
GLY A  57
ILE A  73
PHE A  71
 None
 0.88A 1xf1A-2w5oA:
undetectable		 1xf1A-2w5oA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjv REGULATOR OF
RIBONUCLEASE
ACTIVITY A

(Escherichia
coli) 		PF03737
(RraA-like) 		4 LEU A 153
HIS A 143
ILE A  36
PHE A 139
 None
 0.85A 1xf1A-2yjvA:
3.9		 1xf1A-2yjvA:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 195
GLY A 199
HIS A 200
ILE A 201
 None
 0.88A 1xf1A-2z7rA:
undetectable		 1xf1A-2z7rA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b70 ENOYL REDUCTASE

(Aspergillus
terreus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A 360
GLY A 335
HIS A 338
ILE A 339
 None
 0.96A 1xf1A-3b70A:
undetectable		 1xf1A-3b70A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bf5 RIBOKINASE RELATED
PROTEIN

(Thermoplasma
acidophilum) 		PF00294
(PfkB) 		4 LEU A  10
GLY A  41
ILE A  72
PHE A  36
 None
 0.96A 1xf1A-3bf5A:
undetectable		 1xf1A-3bf5A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bpk NITRILOTRIACETATE
MONOOXYGENASE
COMPONENT B

(Bacillus cereus) 		PF01613
(Flavin_Reduct) 		4 LEU A 179
GLY A 178
HIS A 175
ILE A 174
 None
 0.94A 1xf1A-3bpkA:
undetectable		 1xf1A-3bpkA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3j ENHANCER OF
MRNA-DECAPPING
PROTEIN 3

(Homo sapiens) 		PF03853
(YjeF_N)
PF09532
(FDF) 		4 LEU A 368
GLY A 342
HIS A 344
ILE A 378
 None
 0.93A 1xf1A-3d3jA:
2.1		 1xf1A-3d3jA:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3k ENHANCER OF
MRNA-DECAPPING
PROTEIN 3

(Homo sapiens) 		PF03853
(YjeF_N) 		4 LEU A 368
GLY A 342
HIS A 344
ILE A 378
 None
 0.88A 1xf1A-3d3kA:
undetectable		 1xf1A-3d3kA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmp URACIL
PHOSPHORIBOSYLTRANSF
ERASE

(Burkholderia
pseudomallei) 		PF14681
(UPRTase) 		4 LEU A 123
GLY A 104
HIS A 105
ILE A 106
 None
 0.83A 1xf1A-3dmpA:
undetectable		 1xf1A-3dmpA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3doh ESTERASE

(Thermotoga
maritima) 		PF02230
(Abhydrolase_2) 		4 LEU A  53
GLY A  50
ILE A  48
PHE A 134
 None
 0.81A 1xf1A-3dohA:
1.9		 1xf1A-3dohA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpl NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Clostridium
beijerinckii;
Thermoanaerobacter
brockii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A 351
GLY A 326
HIS A 329
ILE A 330
 None
 0.82A 1xf1A-3fplA:
2.5		 1xf1A-3fplA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3goh ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING

(Shewanella
oneidensis) 		PF08240
(ADH_N) 		4 LEU A 218
GLY A 222
HIS A 223
ILE A 224
 None
 0.98A 1xf1A-3gohA:
undetectable		 1xf1A-3gohA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gz5 MUTT/NUDIX FAMILY
PROTEIN

(Shewanella
oneidensis) 		PF00293
(NUDIX) 		4 LEU A  38
GLY A  51
HIS A 142
ILE A 146
 None
 0.69A 1xf1A-3gz5A:
undetectable		 1xf1A-3gz5A:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gz8 MUTT/NUDIX FAMILY
PROTEIN

(Shewanella
oneidensis) 		PF00293
(NUDIX) 		4 LEU A  38
GLY A  51
HIS A 142
ILE A 146
 None
None
APR  A 302 (-4.0A)
None
 0.70A 1xf1A-3gz8A:
undetectable		 1xf1A-3gz8A:
11.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5q PYRIMIDINE-NUCLEOSID
E PHOSPHORYLASE

(Staphylococcus
aureus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		4 LEU A 361
GLY A 377
HIS A 398
ILE A 397
 None
 0.98A 1xf1A-3h5qA:
undetectable		 1xf1A-3h5qA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdn SERINE/THREONINE-PRO
TEIN KINASE SGK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 230
GLY A 234
HIS A 235
ILE A 236
 None
 0.89A 1xf1A-3hdnA:
undetectable		 1xf1A-3hdnA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwp COPPER HOMEOSTASIS
PROTEIN CUTC HOMOLOG

(Homo sapiens) 		PF03932
(CutC) 		4 LEU A 119
GLY A 123
HIS A 124
ILE A 125
 None
 0.87A 1xf1A-3iwpA:
undetectable		 1xf1A-3iwpA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6d PUTATIVE
OXIDOREDUCTASE

(Pseudomonas
putida) 		PF03446
(NAD_binding_2) 		4 LEU A  92
GLY A 120
HIS A 121
ILE A  97
 None
 0.95A 1xf1A-3l6dA:
undetectable		 1xf1A-3l6dA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lfu DNA HELICASE II

(Escherichia
coli) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		4 LEU A 559
GLY A 602
ILE A 572
PHE A 632
 None
 0.92A 1xf1A-3lfuA:
undetectable		 1xf1A-3lfuA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6u LYSR TYPE REGULATOR
OF TSAMBCD

(Comamonas
testosteroni) 		PF03466
(LysR_substrate) 		4 GLY A  92
HIS A  93
ILE A  94
PHE A 118
 None
 0.90A 1xf1A-3n6uA:
undetectable		 1xf1A-3n6uA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o96 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00169
(PH) 		4 LEU A 282
GLY A 286
HIS A 287
ILE A 288
 LEU  A 282 ( 0.6A)
GLY  A 286 ( 0.0A)
HIS  A 287 ( 1.0A)
ILE  A 288 ( 0.7A)
 0.92A 1xf1A-3o96A:
undetectable		 1xf1A-3o96A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfq PROTEIN KINASE C
BETA TYPE

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00130
(C1_1)
PF00168
(C2)
PF00433
(Pkinase_C) 		4 LEU A 474
GLY A 478
HIS A 479
ILE A 480
 None
 0.94A 1xf1A-3pfqA:
2.7		 1xf1A-3pfqA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pps LACCASE

(Thielavia
arenaria) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 LEU A  98
GLY A  97
HIS A  96
ILE A 154
 None
None
CU  A 603 ( 3.1A)
None
 0.82A 1xf1A-3ppsA:
undetectable		 1xf1A-3ppsA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfv CDC42BPB PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 208
GLY A 212
HIS A 213
ILE A 214
 None
 0.90A 1xf1A-3qfvA:
undetectable		 1xf1A-3qfvA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qsg NAD-BINDING
PHOSPHOGLUCONATE
DEHYDROGENASE-LIKE
PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF03807
(F420_oxidored)
PF09130
(DUF1932) 		4 LEU A  83
GLY A  80
HIS A 110
ILE A 107
 None
 0.89A 1xf1A-3qsgA:
undetectable		 1xf1A-3qsgA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rip GAMMA-TUBULIN
COMPLEX COMPONENT 4

(Homo sapiens) 		PF04130
(Spc97_Spc98) 		4 GLY A 150
HIS A 149
ILE A 263
PHE A 203
 None
 0.97A 1xf1A-3ripA:
undetectable		 1xf1A-3ripA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubd RIBOSOMAL PROTEIN S6
KINASE ALPHA-3

(Mus musculus) 		PF00069
(Pkinase) 		4 LEU A 201
GLY A 205
HIS A 206
ILE A 207
 None
 0.84A 1xf1A-3ubdA:
undetectable		 1xf1A-3ubdA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9e LACCASE

(Botrytis aclada) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 LEU A 142
HIS A 131
ILE A  86
PHE A 134
 None
CU  A 603 (-3.2A)
None
None
 0.98A 1xf1A-3v9eA:
1.6		 1xf1A-3v9eA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3voc BETA/ALPHA-AMYLASE

(Paenibacillus
polymyxa) 		PF01373
(Glyco_hydro_14) 		4 LEU A 324
GLY A 358
ILE A 376
PHE A 379
 None
 0.94A 1xf1A-3vocA:
1.4		 1xf1A-3vocA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpq GLUTATHIONE
S-TRANSFERASE SIGMA

(Bombyx mori) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 LEU A 137
GLY A 142
HIS A 143
ILE A 144
 None
PGO  A 311 (-3.2A)
PGO  A 311 ( 4.1A)
None
 0.81A 1xf1A-3vpqA:
undetectable		 1xf1A-3vpqA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ap3 STEROID
MONOOXYGENASE

(Rhodococcus
rhodochrous) 		PF00743
(FMO-like) 		4 LEU A 469
GLY A 476
ILE A 546
PHE A 544
 None
 0.82A 1xf1A-4ap3A:
undetectable		 1xf1A-4ap3A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btp P1

(Pseudomonas
phage phi8) 		no annotation 4 LEU A 496
GLY A 494
ILE A 584
PHE A  53
 None
 0.90A 1xf1A-4btpA:
undetectable		 1xf1A-4btpA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3h DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA43

(Saccharomyces
cerevisiae) 		PF03876
(SHS2_Rpb7-N) 		4 LEU G 147
GLY G 146
HIS G 144
ILE G 157
 None
 0.77A 1xf1A-4c3hG:
undetectable		 1xf1A-4c3hG:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c82 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Plasmodium
falciparum) 		PF02542
(YgbB) 		4 LEU A 100
GLY A 118
HIS A  73
ILE A 227
 None
None
ZN  A1240 (-3.2A)
None
 0.87A 1xf1A-4c82A:
2.1		 1xf1A-4c82A:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ed5 ELAV-LIKE PROTEIN 1

(Homo sapiens) 		PF00076
(RRM_1) 		4 LEU A 113
GLY A 112
ILE A 110
PHE A 167
 None
GOL  A 205 ( 3.8A)
None
None
 0.87A 1xf1A-4ed5A:
undetectable		 1xf1A-4ed5A:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gv1 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 LEU A 282
GLY A 286
HIS A 287
ILE A 288
 None
 0.89A 1xf1A-4gv1A:
undetectable		 1xf1A-4gv1A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h3s GLUTAMINE-TRNA
LIGASE

(Saccharomyces
cerevisiae) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C)
PF04557
(tRNA_synt_1c_R2) 		4 LEU A 489
GLY A 267
HIS A 265
ILE A 491
 GOL  A 903 (-4.9A)
GOL  A 903 (-3.0A)
GOL  A 903 (-4.0A)
None
 0.95A 1xf1A-4h3sA:
undetectable		 1xf1A-4h3sA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i0n NECROTIC ENTERITIS
TOXIN B

(Clostridium
perfringens) 		PF07968
(Leukocidin) 		4 LEU A  91
GLY A  76
ILE A 311
PHE A 309
 None
 0.87A 1xf1A-4i0nA:
undetectable		 1xf1A-4i0nA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN

(Lactobacillus
acidophilus) 		PF06100
(MCRA) 		4 LEU A 211
GLY A 210
ILE A 208
PHE A 204
 None
None
None
MPD  A 604 (-3.6A)
 0.95A 1xf1A-4ia5A:
undetectable		 1xf1A-4ia5A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6l PUTATIVE
PERTUSSIS-LIKE TOXIN
SUBUNIT

(Salmonella
enterica) 		PF02918
(Pertussis_S2S3) 		4 LEU A 122
GLY A 124
HIS A 102
ILE A 101
 None
 0.98A 1xf1A-4k6lA:
undetectable		 1xf1A-4k6lA:
8.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k9d GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Brugia malayi) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 LEU A 254
GLY A 174
HIS A 170
ILE A 169
 None
 0.73A 1xf1A-4k9dA:
2.2		 1xf1A-4k9dA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lsm GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE,
CYTOSOLIC

(Trypanosoma
cruzi) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 LEU A 253
GLY A 173
HIS A 169
ILE A 168
 None
 0.76A 1xf1A-4lsmA:
undetectable		 1xf1A-4lsmA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 LEU A 734
GLY A 712
HIS A 688
ILE A 689
 None
 0.82A 1xf1A-4mn8A:
undetectable		 1xf1A-4mn8A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 LEU A 734
GLY A 712
HIS A 688
ILE A 689
 None
 0.85A 1xf1A-4mnaA:
undetectable		 1xf1A-4mnaA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nko ENGINEERED SCFV
LIGHT CHAIN

(Mus musculus) 		PF07686
(V-set) 		4 LEU A  78
GLY A  69
ILE A  53
PHE A  67
 None
 0.98A 1xf1A-4nkoA:
2.7		 1xf1A-4nkoA:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o59 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Bos taurus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 LEU O 246
GLY O 166
HIS O 162
ILE O 161
 None
 0.70A 1xf1A-4o59O:
undetectable		 1xf1A-4o59O:
16.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q82 PHOSPHOLIPASE/CARBOX
YLESTERASE

(Haliangium
ochraceum) 		no annotation 4 LEU A 277
GLY A 280
HIS A 281
ILE A 283
 None
 0.91A 1xf1A-4q82A:
2.3		 1xf1A-4q82A:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9z HUMAN PROTEIN KINASE
C THETA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 LEU A 512
GLY A 516
HIS A 517
ILE A 518
 None
 0.89A 1xf1A-4q9zA:
undetectable		 1xf1A-4q9zA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wu0 SIMILAR TO YTER
(BACILUS SUBTILIS)

(Clostridium
acetobutylicum) 		PF07470
(Glyco_hydro_88) 		4 LEU A 132
GLY A 131
HIS A 119
ILE A 127
 None
 0.72A 1xf1A-4wu0A:
undetectable		 1xf1A-4wu0A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y49 N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX CATALYTIC
SUBUNIT ARD1

(Saccharomyces
cerevisiae) 		PF00583
(Acetyltransf_1) 		4 LEU B 141
GLY B 113
HIS B 114
ILE B 115
 None
 0.93A 1xf1A-4y49B:
undetectable		 1xf1A-4y49B:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ybn FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN

(Mycolicibacterium
smegmatis) 		PF12900
(Pyridox_ox_2) 		4 LEU A  71
GLY A  64
HIS A  63
ILE A  51
 None
HEM  A 304 (-4.0A)
HEM  A 304 ( 3.6A)
None
 0.95A 1xf1A-4ybnA:
undetectable		 1xf1A-4ybnA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ybn FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN

(Mycolicibacterium
smegmatis) 		PF12900
(Pyridox_ox_2) 		4 LEU A  71
GLY A  64
HIS A  63
ILE A  62
 None
HEM  A 304 (-4.0A)
HEM  A 304 ( 3.6A)
None
 0.97A 1xf1A-4ybnA:
undetectable		 1xf1A-4ybnA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywe PUTATIVE ALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		4 LEU A 213
GLY A 144
HIS A 145
ILE A 146
 None
 0.98A 1xf1A-4yweA:
undetectable		 1xf1A-4yweA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bnt ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Pseudomonas
aeruginosa) 		no annotation 4 LEU C 144
GLY C 145
HIS C 299
ILE C 296
 None
 0.97A 1xf1A-5bntC:
undetectable		 1xf1A-5bntC:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwj SENSORY TRANSDUCTION
HISTIDINE KINASE,
PUTATIVE

(Borreliella
burgdorferi) 		PF00497
(SBP_bac_3) 		4 LEU A  53
GLY A  52
ILE A  54
PHE A  38
 None
 0.96A 1xf1A-5bwjA:
undetectable		 1xf1A-5bwjA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c7i GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
TESTIS-SPECIFIC

(Mus musculus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 LEU O 353
GLY O 273
HIS O 269
ILE O 268
 None
 0.72A 1xf1A-5c7iO:
2.9		 1xf1A-5c7iO:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c7o GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
TESTIS-SPECIFIC

(Homo sapiens) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 LEU O 321
GLY O 241
HIS O 237
ILE O 236
 None
 0.70A 1xf1A-5c7oO:
2.9		 1xf1A-5c7oO:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6s INTEGRIN ALPHA-L

(Homo sapiens) 		PF00092
(VWA)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		4 LEU A 503
GLY A 562
HIS A 561
ILE A 560
 None
 0.73A 1xf1A-5e6sA:
2.6		 1xf1A-5e6sA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT THETA

(Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1) 		4 LEU q 111
GLY q 108
HIS q  39
ILE q  35
 None
 0.95A 1xf1A-5gw5q:
2.6		 1xf1A-5gw5q:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN

(Chaetomium
thermophilum) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		4 LEU A 973
HIS A 922
ILE A 902
PHE A 900
 None
 0.97A 1xf1A-5hy7A:
undetectable		 1xf1A-5hy7A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hz1 PROBABLE LRR
RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE
AT4G26540

(Arabidopsis
thaliana) 		PF13855
(LRR_8) 		4 LEU B 202
GLY B 179
HIS B 156
ILE B 157
 None
 0.78A 1xf1A-5hz1B:
undetectable		 1xf1A-5hz1B:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5icu COPC

(Methylosinus
trichosporium) 		PF04234
(CopC) 		4 LEU A 102
GLY A 106
HIS A 107
ILE A 108
 None
None
CU  A 201 (-3.0A)
None
 0.97A 1xf1A-5icuA:
5.2		 1xf1A-5icuA:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lkd GLUTATHIONE
S-TRANSFERASE
OMEGA-LIKE 2

(Saccharomyces
cerevisiae) 		PF13409
(GST_N_2)
PF13410
(GST_C_2) 		4 LEU A  61
GLY A  60
HIS A 194
PHE A 189
 None
 0.88A 1xf1A-5lkdA:
undetectable		 1xf1A-5lkdA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mif 'CARBOXYL ESTERASE 2

(Tuber
melanosporum) 		PF07859
(Abhydrolase_3) 		4 LEU A 325
GLY A 318
HIS A 317
ILE A 316
 None
 0.88A 1xf1A-5mifA:
2.7		 1xf1A-5mifA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrw POTASSIUM-TRANSPORTI
NG ATPASE
ATP-BINDING SUBUNIT

(Escherichia
coli) 		PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase) 		4 LEU B 270
GLY B 269
ILE B 628
PHE B  81
 None
 0.93A 1xf1A-5mrwB:
2.3		 1xf1A-5mrwB:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 4 LEU B 153
GLY B 150
HIS B 139
ILE B   7
 None
 0.86A 1xf1A-5n5nB:
undetectable		 1xf1A-5n5nB:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3f TUBULIN ALPHA-1
CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		4 LEU A 154
GLY A 151
HIS A 140
ILE A   7
 None
 0.89A 1xf1A-5w3fA:
undetectable		 1xf1A-5w3fA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yjh PERIOSTIN

(Homo sapiens) 		no annotation 4 LEU A 105
GLY A 103
HIS A 100
ILE A 126
 None
 0.96A 1xf1A-5yjhA:
undetectable		 1xf1A-5yjhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ymu OUTER CAPSID PROTEIN
VP4

(Rotavirus A) 		no annotation 4 LEU A  43
HIS A  90
ILE A  65
PHE A  88
 None
 0.98A 1xf1A-5ymuA:
undetectable		 1xf1A-5ymuA:
undetectable