SIMILAR PATTERNS OF AMINO ACIDS FOR 1XF0_A_ASDA600_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		5 LEU A  54
TRP A  86
MET A 120
ASN A 167
PRO A 318
 None
None
None
NAP  A1001 (-3.1A)
None
 0.51A 1xf0A-2fvlA:
51.5		 1xf0A-2fvlA:
84.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ipf (3(17)ALPHA-HYDROXYS
TEROID
DEHYDROGENASE)

(Mus musculus) 		PF00248
(Aldo_ket_red) 		5 TRP A  86
MET A 120
ASN A 167
TYR A 216
PRO A 318
 None
None
NAP  A   1 (-3.3A)
NAP  A   1 (-3.5A)
None
 0.59A 1xf0A-2ipfA:
50.4		 1xf0A-2ipfA:
71.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3cav 3-OXO-5-BETA-STEROID
4-DEHYDROGENASE

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		5 TRP A  89
MET A 123
ASN A 170
TYR A 219
PRO A 321
 None
None
NAP  A 327 (-3.6A)
NAP  A 327 (-3.4A)
None
 0.49A 1xf0A-3cavA:
47.5		 1xf0A-3cavA:
55.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5az0 UNCHARACTERIZED
PROTEIN

(Bombyx mori) 		PF00248
(Aldo_ket_red) 		5 TRP A 106
MET A 140
ASN A 176
TYR A 223
PRO A 325
 None
 0.87A 1xf0A-5az0A:
39.3		 1xf0A-5az0A:
33.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3

(Homo sapiens) 		no annotation 5 LEU A  54
TRP A  86
ASN A 167
TRP A 227
PRO A 318
 None
None
NAP  A 401 ( 3.3A)
CJ2  A 402 ( 4.8A)
None
 1.22A 1xf0A-6f2uA:
50.8		 1xf0A-6f2uA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3

(Homo sapiens) 		no annotation 6 LEU A  54
TRP A  86
MET A 120
ASN A 167
TYR A 216
PRO A 318
 None
None
CJ2  A 402 ( 4.7A)
NAP  A 401 ( 3.3A)
NAP  A 401 ( 3.2A)
None
 0.33A 1xf0A-6f2uA:
50.8		 1xf0A-6f2uA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3

(Homo sapiens) 		no annotation 6 LEU A  54
TRP A  86
MET A 120
SER A 129
ASN A 167
PRO A 318
 None
None
CJ2  A 402 ( 4.7A)
None
NAP  A 401 ( 3.3A)
None
 0.62A 1xf0A-6f2uA:
50.8		 1xf0A-6f2uA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3

(Homo sapiens) 		no annotation 5 LEU A  54
TRP A  86
SER A 129
ASN A 167
PHE A 306
 None
None
None
NAP  A 401 ( 3.3A)
CJ2  A 402 (-3.8A)
 1.41A 1xf0A-6f2uA:
50.8		 1xf0A-6f2uA:
100.00