SIMILAR PATTERNS OF AMINO ACIDS FOR 1XDS_B_SAMB9635_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dl5 | PROTEIN-L-ISOASPARTATEO-METHYLTRANSFERASE (Thermotogamaritima) |
PF01135(PCMT) | 5 | GLY A 83GLY A 84GLY A 85GLU A 107ASP A 134 | SAH A 699 (-3.2A)SAH A 699 (-4.2A)SAH A 699 (-3.5A)SAH A 699 (-2.9A)SAH A 699 (-3.5A) | 0.72A | 1xdsB-1dl5A:6.9 | 1xdsB-1dl5A:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dwu | RIBOSOMAL PROTEIN L1 (Methanothermococcusthermolithotrophicus) |
PF00687(Ribosomal_L1) | 5 | GLY A 127GLY A 124LEU A 119PHE A 105ASN A 100 | None | 1.17A | 1xdsB-1dwuA:undetectable | 1xdsB-1dwuA:21.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e3h | GUANOSINEPENTAPHOSPHATESYNTHETASE (Streptomycesantibioticus) |
PF00013(KH_1)PF01138(RNase_PH)PF03726(PNPase) | 5 | GLY A 158GLY A 157LEU A 101PRO A 105ASP A 134 | NoneNoneNoneNoneSO4 A 903 (-3.8A) | 1.00A | 1xdsB-1e3hA:undetectable | 1xdsB-1e3hA:20.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fp2 | ISOFLAVONEO-METHYLTRANSFERASE (Medicago sativa) |
PF00891(Methyltransf_2)PF08100(Dimerisation) | 7 | TRP A 151GLY A 196GLY A 197GLY A 198ASP A 239ASN A 258TRP A 259 | SAH A1699 ( 3.8A)SAH A1699 (-3.8A)SAH A1699 ( 4.2A)SAH A1699 ( 3.9A)SAH A1699 (-3.8A)HMO A2000 (-3.1A)None | 0.58A | 1xdsB-1fp2A:29.1 | 1xdsB-1fp2A:26.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fpq | ISOLIQUIRITIGENIN2'-O-METHYLTRANSFERASE (Medicago sativa) |
PF00891(Methyltransf_2)PF08100(Dimerisation) | 7 | GLY A 217GLY A 218GLY A 219LEU A 241ASP A 260ASN A 279TRP A 280 | SAM A1699 (-3.6A)NoneNoneSAM A1699 (-4.2A)SAM A1699 (-3.8A)SAM A1699 (-4.0A)None | 0.45A | 1xdsB-1fpqA:20.4 | 1xdsB-1fpqA:26.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hjo | PROTEIN (HEAT-SHOCK70KD PROTEIN) (Homo sapiens) |
PF00012(HSP70) | 5 | GLY A 230GLY A 202GLY A 203LEU A 228ASN A 235 | ADP A 383 (-3.2A)ADP A 383 (-3.2A)NoneNoneNone | 0.93A | 1xdsB-1hjoA:undetectable | 1xdsB-1hjoA:25.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hww | ALPHA-MANNOSIDASE II (Drosophilamelanogaster) |
PF01074(Glyco_hydro_38)PF07748(Glyco_hydro_38C)PF09261(Alpha-mann_mid) | 5 | GLY A 185GLY A 164GLY A 163PRO A 197SER A 132 | None | 0.87A | 1xdsB-1hwwA:undetectable | 1xdsB-1hwwA:17.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kyw | CAFFEIC ACID3-O-METHYLTRANSFERASE (Medicago sativa) |
PF00891(Methyltransf_2)PF08100(Dimerisation) | 5 | GLY A 208GLY A 209GLY A 210LEU A 232ASP A 251 | None | 0.30A | 1xdsB-1kywA:25.0 | 1xdsB-1kywA:25.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lvl | DIHYDROLIPOAMIDEDEHYDROGENASE (Pseudomonasputida) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | GLY A 156GLY A 155LEU A 152PRO A 153ASN A 240 | None | 1.12A | 1xdsB-1lvlA:2.6 | 1xdsB-1lvlA:24.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mjf | SPERMIDINE SYNTHASE (Pyrococcusfuriosus) |
PF01564(Spermine_synth)PF17284(Spermine_synt_N) | 5 | GLY A 82GLY A 83GLY A 84GLU A 104ASP A 141 | None | 0.68A | 1xdsB-1mjfA:11.5 | 1xdsB-1mjfA:20.73 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1qzz | ACLACINOMYCIN-10-HYDROXYLASE (Streptomycespurpurascens) |
PF00891(Methyltransf_2) | 12 | TRP A 146GLY A 190GLY A 191GLY A 192GLU A 213LEU A 214PRO A 217ASP A 240PHE A 241SER A 255ASN A 260TRP A 261 | SAM A 635 (-4.2A)SAM A 635 (-3.8A)SAM A 635 ( 3.2A)SAM A 635 (-3.5A)SAM A 635 (-2.9A)SAM A 635 (-4.2A)SAM A 635 (-4.6A)SAM A 635 (-3.7A)SAM A 635 (-3.4A)SAM A 635 ( 2.7A)SAM A 635 (-3.8A)None | 0.38A | 1xdsB-1qzzA:38.9 | 1xdsB-1qzzA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1qzz | ACLACINOMYCIN-10-HYDROXYLASE (Streptomycespurpurascens) |
PF00891(Methyltransf_2) | 8 | TRP A 146GLY A 191GLU A 213LEU A 214ASP A 240PHE A 241ASN A 260TRP A 261 | SAM A 635 (-4.2A)SAM A 635 ( 3.2A)SAM A 635 (-2.9A)SAM A 635 (-4.2A)SAM A 635 (-3.7A)SAM A 635 (-3.4A)SAM A 635 (-3.8A)None | 1.00A | 1xdsB-1qzzA:38.9 | 1xdsB-1qzzA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1qzz | ACLACINOMYCIN-10-HYDROXYLASE (Streptomycespurpurascens) |
PF00891(Methyltransf_2) | 6 | TRP A 146GLY A 191GLU A 213LEU A 214PRO A 217SER A 255 | SAM A 635 (-4.2A)SAM A 635 ( 3.2A)SAM A 635 (-2.9A)SAM A 635 (-4.2A)SAM A 635 (-4.6A)SAM A 635 ( 2.7A) | 1.11A | 1xdsB-1qzzA:38.9 | 1xdsB-1qzzA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u2v | ACTIN-RELATEDPROTEIN 2 (Bos taurus) |
PF00022(Actin) | 5 | GLY B 256GLY B 255GLU B 257LEU B 196PHE B 259 | None | 1.12A | 1xdsB-1u2vB:undetectable | 1xdsB-1u2vB:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u60 | PROBABLE GLUTAMINASEYBAS (Escherichiacoli) |
PF04960(Glutaminase) | 5 | GLY A 265GLY A 264GLY A 263LEU A 64SER A 280 | None | 0.87A | 1xdsB-1u60A:undetectable | 1xdsB-1u60A:22.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ulv | GLUCODEXTRANASE (Arthrobacterglobiformis) |
PF00723(Glyco_hydro_15)PF09136(Glucodextran_B)PF09137(Glucodextran_N)PF09985(Glucodextran_C) | 5 | TRP A 313GLY A 586GLY A 572GLY A 588ASP A 578 | None | 0.94A | 1xdsB-1ulvA:undetectable | 1xdsB-1ulvA:17.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x1b | CRTF-RELATED PROTEIN (Chlorobaculumtepidum) |
PF00891(Methyltransf_2) | 5 | GLY A 177GLY A 178GLY A 179LEU A 201ASP A 227 | SAH A4261 (-3.8A)SAH A4261 ( 4.2A)SAH A4261 (-3.3A)SAH A4261 (-4.0A)SAH A4261 (-2.9A) | 0.50A | 1xdsB-1x1bA:14.6 | 1xdsB-1x1bA:26.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xj5 | SPERMIDINE SYNTHASE1 (Arabidopsisthaliana) |
PF01564(Spermine_synth)PF17284(Spermine_synt_N) | 5 | GLY A 128GLY A 129GLY A 130GLU A 151ASP A 182 | None | 0.53A | 1xdsB-1xj5A:11.7 | 1xdsB-1xj5A:24.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zb7 | NEUROTOXIN (Clostridiumbotulinum) |
PF01742(Peptidase_M27) | 5 | GLY A 238GLY A 241PRO A 182ASP A 173ASN A 157 | None | 1.15A | 1xdsB-1zb7A:undetectable | 1xdsB-1zb7A:17.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zgj | ISOFLAVANONE4'-O-METHYLTRANSFERASE' (Medicagotruncatula) |
PF00891(Methyltransf_2)PF08100(Dimerisation) | 5 | GLY A 207GLY A 208GLY A 209ASP A 250TRP A 270 | SAH A3994 (-3.9A)SAH A3994 ( 4.3A)SAH A3994 ( 4.0A)SAH A3994 (-3.4A)None | 0.47A | 1xdsB-1zgjA:4.0 | 1xdsB-1zgjA:29.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bmy | RIPENING-ASSOCIATEDPROTEIN (Musa acuminata) |
PF01419(Jacalin) | 5 | GLY A 128GLY A 15GLY A 14ASP A 19PHE A 18 | None | 1.16A | 1xdsB-2bmyA:undetectable | 1xdsB-2bmyA:17.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fff | PENICILLIN-BINDINGPROTEIN 1B (Streptococcuspneumoniae) |
PF00905(Transpeptidase) | 5 | GLY B 557GLY B 558GLY B 559ASN B 660TRP B 662 | None | 0.84A | 1xdsB-2fffB:undetectable | 1xdsB-2fffB:23.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ip2 | PROBABLEPHENAZINE-SPECIFICMETHYLTRANSFERASE (Pseudomonasaeruginosa) |
PF00891(Methyltransf_2)PF16864(Dimerisation2) | 5 | GLY A 175GLY A 176GLY A 177ASP A 225SER A 240 | None | 0.43A | 1xdsB-2ip2A:24.9 | 1xdsB-2ip2A:28.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j3t | TRAFFICKING PROTEINPARTICLE COMPLEXSUBUNIT 6A (Homo sapiens) |
PF04051(TRAPP) | 5 | GLY B 39GLY B 41GLY B 125GLU B 38ASP B 22 | None | 1.16A | 1xdsB-2j3tB:undetectable | 1xdsB-2j3tB:19.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jch | PENICILLIN-BINDINGPROTEIN 1B (Streptococcuspneumoniae) |
PF00905(Transpeptidase)PF00912(Transgly) | 5 | GLY A 557GLY A 558GLY A 559ASN A 660TRP A 662 | None | 1.00A | 1xdsB-2jchA:undetectable | 1xdsB-2jchA:19.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jgr | YEGS (Escherichiacoli) |
PF00781(DAGK_cat) | 5 | GLY A 205GLY A 206GLY A 207LEU A 210ASN A 137 | None | 1.16A | 1xdsB-2jgrA:undetectable | 1xdsB-2jgrA:23.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2lt3 | TRANSCRIPTIONALREGULATOR, CARDFAMILY (Myxococcusxanthus) |
no annotation | 5 | GLY A 75GLU A 76LEU A 66ASP A 62ASN A 38 | None | 1.11A | 1xdsB-2lt3A:undetectable | 1xdsB-2lt3A:14.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2lwj | TRANSCRIPTIONALREGULATOR, CARDFAMILY (Myxococcusxanthus) |
PF02559(CarD_CdnL_TRCF) | 5 | GLY A 129GLU A 130LEU A 120ASP A 116ASN A 92 | None | 1.17A | 1xdsB-2lwjA:undetectable | 1xdsB-2lwjA:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p1r | LIPID KINASE YEGS (Salmonellaenterica) |
PF00781(DAGK_cat) | 5 | GLY A 205GLY A 206GLY A 207LEU A 210ASN A 137 | None | 1.10A | 1xdsB-2p1rA:2.0 | 1xdsB-2p1rA:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pt6 | SPERMIDINE SYNTHASE (Plasmodiumfalciparum) |
PF01564(Spermine_synth)PF17284(Spermine_synt_N) | 5 | GLY A 124GLY A 125GLY A 126GLU A 147ASP A 178 | S4M A 501 (-3.4A)S4M A 501 (-4.2A)S4M A 501 ( 4.4A)S4M A 501 (-2.7A)S4M A 501 (-3.3A) | 0.80A | 1xdsB-2pt6A:7.0 | 1xdsB-2pt6A:20.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q7v | THIOREDOXINREDUCTASE (Deinococcusradiodurans) |
PF07992(Pyr_redox_2) | 5 | GLY A 15GLY A 16GLU A 38ASP A 85ASN A 250 | FAD A 348 (-3.3A)FAD A 348 ( 4.9A)FAD A 348 (-2.7A)NoneFAD A 348 ( 4.1A) | 1.09A | 1xdsB-2q7vA:3.1 | 1xdsB-2q7vA:25.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qyo | O-METHYLTRANSFERASE (Medicagotruncatula) |
PF00891(Methyltransf_2)PF08100(Dimerisation) | 5 | GLY A 201GLY A 202GLY A 203ASP A 244TRP A 264 | SAH A 601 (-3.7A)SAH A 601 ( 4.3A)SAH A 601 ( 3.8A)SAH A 601 (-3.5A)None | 0.30A | 1xdsB-2qyoA:22.0 | 1xdsB-2qyoA:26.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vhd | CYTOCHROME C551PEROXIDASE (Pseudomonasaeruginosa) |
PF00034(Cytochrom_C)PF03150(CCP_MauG) | 5 | GLY A 61GLY A 60LEU A 163PRO A 304ASN A 52 | None | 0.91A | 1xdsB-2vhdA:undetectable | 1xdsB-2vhdA:24.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zsu | SPERMIDINE SYNTHASE (Pyrococcushorikoshii) |
PF01564(Spermine_synth)PF17284(Spermine_synt_N) | 5 | GLY A 84GLY A 85GLY A 86GLU A 107ASP A 144 | NoneAG3 A1001 ( 4.9A)NoneNoneNone | 0.75A | 1xdsB-2zsuA:11.8 | 1xdsB-2zsuA:20.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bgf | F26G19 FABF26G19 FAB (Mus musculus;Mus musculus) |
no annotationno annotation | 5 | GLY L 101GLY L 100GLY L 99LEU H 45SER L 7 | None | 1.12A | 1xdsB-3bgfL:undetectable | 1xdsB-3bgfL:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bkw | S-ADENOSYLMETHIONINEDEPENDENTMETHYLTRANSFERASE (Mesorhizobiumjaponicum) |
PF08241(Methyltransf_11) | 5 | GLY A 50GLY A 52LEU A 73ASP A 96SER A 113 | None | 0.93A | 1xdsB-3bkwA:15.8 | 1xdsB-3bkwA:21.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c6m | SPERMINE SYNTHASE (Homo sapiens) |
PF01564(Spermine_synth)PF17284(Spermine_synt_N) | 5 | GLY A 198GLY A 199GLY A 200GLU A 220ASP A 255 | MTA A 401 (-3.3A)MTA A 401 (-3.9A)MTA A 401 (-3.7A)MTA A 401 (-2.5A)MTA A 401 (-3.6A) | 0.60A | 1xdsB-3c6mA:13.8 | 1xdsB-3c6mA:25.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fe1 | HEAT SHOCK 70 KDAPROTEIN 6 (Homo sapiens) |
PF00012(HSP70) | 5 | GLY A 232GLY A 204GLY A 205LEU A 230ASN A 237 | ADP A 386 (-3.3A)ADP A 386 (-3.2A)NoneNoneNone | 0.85A | 1xdsB-3fe1A:undetectable | 1xdsB-3fe1A:25.61 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3gxo | MMCR (Streptomyceslavendulae) |
PF00891(Methyltransf_2) | 8 | TRP A 146GLY A 190GLY A 191GLY A 192GLU A 213ASP A 240PHE A 241TRP A 261 | SAH A 350 ( 4.0A)SAH A 350 (-4.1A)SAH A 350 (-3.6A)SAH A 350 (-3.6A)SAH A 350 (-2.9A)SAH A 350 (-3.4A)SAH A 350 (-3.6A)None | 0.59A | 1xdsB-3gxoA:30.8 | 1xdsB-3gxoA:32.24 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3gxo | MMCR (Streptomyceslavendulae) |
PF00891(Methyltransf_2) | 6 | TRP A 146GLY A 192GLU A 213ASP A 240PHE A 241TRP A 261 | SAH A 350 ( 4.0A)SAH A 350 (-3.6A)SAH A 350 (-2.9A)SAH A 350 (-3.4A)SAH A 350 (-3.6A)None | 1.06A | 1xdsB-3gxoA:30.8 | 1xdsB-3gxoA:32.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hst | PROTEINRV2228C/MT2287 (Mycobacteriumtuberculosis) |
PF13456(RVT_3) | 6 | GLY B 9GLY B 52LEU B 125ASP B 128SER B 74ASN B 119 | None | 1.32A | 1xdsB-3hstB:undetectable | 1xdsB-3hstB:17.20 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3i58 | O-METHYLTRANSFERASE (Streptomycescarzinostaticus) |
PF00891(Methyltransf_2) | 9 | TRP A 133GLY A 177GLY A 178GLY A 179LEU A 201PRO A 204PHE A 228SER A 242TRP A 248 | SAH A 401 (-3.8A)SAH A 401 (-3.9A)SAH A 401 (-3.6A)SAH A 401 (-3.6A)SAH A 401 (-4.4A)SAH A 401 ( 4.7A)SAH A 401 (-3.4A)SAH A 401 (-2.8A)None | 0.49A | 1xdsB-3i58A:30.9 | 1xdsB-3i58A:43.13 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3i58 | O-METHYLTRANSFERASE (Streptomycescarzinostaticus) |
PF00891(Methyltransf_2) | 5 | TRP A 133GLY A 179LEU A 201PHE A 228TRP A 248 | SAH A 401 (-3.8A)SAH A 401 (-3.6A)SAH A 401 (-4.4A)SAH A 401 (-3.4A)None | 1.01A | 1xdsB-3i58A:30.9 | 1xdsB-3i58A:43.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l4i | HEAT SHOCK 70(HSP70) PROTEIN (Cryptosporidiumparvum) |
PF00012(HSP70) | 5 | GLY A 246GLY A 218GLY A 219LEU A 244ASN A 251 | ADP A 401 (-3.3A)ADP A 401 (-3.3A)NoneNoneNone | 0.88A | 1xdsB-3l4iA:undetectable | 1xdsB-3l4iA:24.24 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3lst | CALO1METHYLTRANSFERASE (Micromonosporaechinospora) |
PF00891(Methyltransf_2) | 7 | GLY A 189GLY A 190GLY A 191ASP A 237PHE A 238ASN A 256TRP A 257 | SAH A 346 (-4.0A)SAH A 346 (-3.6A)SAH A 346 ( 3.7A)SAH A 346 (-3.6A)SAH A 346 (-3.4A)NoneNone | 0.41A | 1xdsB-3lstA:24.5 | 1xdsB-3lstA:34.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m6x | RRNA METHYLASE (Thermusthermophilus) |
PF01189(Methyltr_RsmB-F)PF17125(Methyltr_RsmF_N)PF17126(RsmF_methylt_CI) | 5 | GLY A 184GLY A 291LEU A 25PRO A 284PHE A 186 | NoneNoneNoneNoneCXM A 1 ( 4.9A) | 1.14A | 1xdsB-3m6xA:10.8 | 1xdsB-3m6xA:24.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3noq | THIJ/PFPI FAMILYPROTEIN (Pseudomonasfluorescens) |
PF01965(DJ-1_PfpI) | 5 | GLY A 73GLY A 71GLY A 70ASP A 80SER A 46 | NoneNHE A 501 (-2.7A)NHE A 501 ( 4.7A)NoneNone | 0.91A | 1xdsB-3noqA:3.1 | 1xdsB-3noqA:23.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3noq | THIJ/PFPI FAMILYPROTEIN (Pseudomonasfluorescens) |
PF01965(DJ-1_PfpI) | 5 | GLY A 73GLY A 71GLY A 70PRO A 69ASP A 80 | NoneNHE A 501 (-2.7A)NHE A 501 ( 4.7A)NoneNone | 1.17A | 1xdsB-3noqA:3.1 | 1xdsB-3noqA:23.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o4f | SPERMIDINE SYNTHASE (Escherichiacoli) |
PF01564(Spermine_synth)PF17284(Spermine_synt_N) | 5 | GLY A 85GLY A 86GLY A 87GLU A 108ASP A 139 | None | 1.05A | 1xdsB-3o4fA:12.0 | 1xdsB-3o4fA:21.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o4f | SPERMIDINE SYNTHASE (Escherichiacoli) |
PF01564(Spermine_synth)PF17284(Spermine_synt_N) | 5 | GLY A 85GLY A 86GLY A 87GLU A 108ASP A 140 | None | 0.80A | 1xdsB-3o4fA:12.0 | 1xdsB-3o4fA:21.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o4r | DEHYDROGENASE/REDUCTASE SDR FAMILYMEMBER 4 (Homo sapiens) |
PF13561(adh_short_C2) | 5 | GLY A 213GLY A 271GLY A 272LEU A 242SER A 276 | NAP A 601 (-4.9A)NoneNoneNoneNone | 1.04A | 1xdsB-3o4rA:8.1 | 1xdsB-3o4rA:23.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p9c | CAFFEIC ACIDO-METHYLTRANSFERASE (Lolium perenne) |
PF00891(Methyltransf_2)PF08100(Dimerisation) | 6 | GLY A 205GLY A 206GLY A 207LEU A 229ASP A 248TRP A 268 | SAH A 401 (-3.8A)SAH A 401 ( 4.0A)SAH A 401 (-3.6A)SAH A 401 (-4.3A)SAH A 401 (-3.6A)None | 0.27A | 1xdsB-3p9cA:24.7 | 1xdsB-3p9cA:27.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rko | NADH-QUINONEOXIDOREDUCTASESUBUNIT M (Escherichiacoli) |
no annotation | 5 | GLY M 129GLY M 126GLY M 125LEU M 6PRO M 10 | None | 0.99A | 1xdsB-3rkoM:undetectable | 1xdsB-3rkoM:21.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rw9 | SPERMIDINE SYNTHASE (Homo sapiens) |
PF01564(Spermine_synth)PF17284(Spermine_synt_N) | 5 | GLY A 101GLY A 102GLY A 103GLU A 124ASP A 155 | DSH A 303 (-3.4A)DSH A 303 ( 4.7A)DSH A 303 (-3.5A)DSH A 303 (-2.6A)DSH A 303 (-3.5A) | 0.79A | 1xdsB-3rw9A:11.1 | 1xdsB-3rw9A:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tt0 | BASIC FIBROBLASTGROWTH FACTORRECEPTOR 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | GLY A 697GLY A 698GLU A 692LEU A 689ASN A 568 | NoneSO4 A 2 (-3.3A)NoneNoneNone | 1.09A | 1xdsB-3tt0A:undetectable | 1xdsB-3tt0A:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u9w | LEUKOTRIENE A-4HYDROLASE (Homo sapiens) |
PF01433(Peptidase_M1)PF09127(Leuk-A4-hydro_C) | 5 | GLY A1344GLY A1345GLY A1347PHE A1340ASN A1500 | IMD A2009 (-4.1A)NoneIMD A2009 (-3.5A)NoneIMD A2010 (-3.7A) | 0.81A | 1xdsB-3u9wA:undetectable | 1xdsB-3u9wA:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vov | GLUCOKINASE (Thermusthermophilus) |
PF00480(ROK) | 5 | GLY A 175GLY A 166GLY A 165GLU A 174LEU A 173 | NoneNoneNoneNone ZN A 401 ( 4.9A) | 1.16A | 1xdsB-3vovA:undetectable | 1xdsB-3vovA:25.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a6e | HYDROXYINDOLEO-METHYLTRANSFERASE (Homo sapiens) |
PF00891(Methyltransf_2)PF16864(Dimerisation2) | 6 | GLY A 187GLY A 188GLY A 189ASP A 236PHE A 237TRP A 257 | SAM A1349 (-3.6A)SAM A1349 ( 4.0A)SAM A1349 ( 3.8A)SAM A1349 (-3.5A)SAM A1349 (-3.5A)None | 0.61A | 1xdsB-4a6eA:28.5 | 1xdsB-4a6eA:26.58 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4d7k | SAM-DEPENDENTMETHYLTRANSFERASES (Streptomycesdavaonensis) |
PF00891(Methyltransf_2) | 6 | GLY A 186GLY A 187GLY A 188ASP A 236PHE A 237TRP A 257 | None | 1.39A | 1xdsB-4d7kA:22.0 | 1xdsB-4d7kA:32.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e9x | MULTICOPPER OXIDASE (unculturedbacterium) |
PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 5 | GLY A1262GLY A1263ASP A1253PHE A1168SER A1149 | None | 1.05A | 1xdsB-4e9xA:undetectable | 1xdsB-4e9xA:21.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4er6 | HISTONE-LYSINEN-METHYLTRANSFERASE,H3 LYSINE-79SPECIFIC (Homo sapiens) |
PF08123(DOT1) | 5 | GLY A 163GLY A 165GLU A 186ASP A 222PHE A 223 | AW2 A 502 (-3.2A)AW2 A 502 (-3.5A)AW2 A 502 (-2.6A)AW2 A 502 (-3.5A)AW2 A 502 (-3.4A) | 0.82A | 1xdsB-4er6A:10.9 | 1xdsB-4er6A:24.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4er6 | HISTONE-LYSINEN-METHYLTRANSFERASE,H3 LYSINE-79SPECIFIC (Homo sapiens) |
PF08123(DOT1) | 5 | GLY A 163GLY A 165GLU A 186PRO A 191ASP A 222 | AW2 A 502 (-3.2A)AW2 A 502 (-3.5A)AW2 A 502 (-2.6A)AW2 A 502 ( 4.8A)AW2 A 502 (-3.5A) | 0.82A | 1xdsB-4er6A:10.9 | 1xdsB-4er6A:24.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4evi | CONIFERYL ALCOHOL9-O-METHYLTRANSFERASE (Linumnodiflorum) |
PF00891(Methyltransf_2)PF08100(Dimerisation) | 5 | GLY A 208GLY A 209GLY A 210LEU A 232TRP A 273 | SAH A 401 (-3.6A)SAH A 401 ( 3.9A)SAH A 401 ( 3.8A)SAH A 401 ( 4.4A)None | 0.43A | 1xdsB-4eviA:26.8 | 1xdsB-4eviA:26.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j8f | HEAT SHOCK 70 KDAPROTEIN 1A/1B,HSC70-INTERACTINGPROTEIN (Homo sapiens;Rattusnorvegicus) |
PF00012(HSP70) | 5 | GLY A 230GLY A 202GLY A 203LEU A 228ASN A 235 | ADP A 601 (-3.4A)ADP A 601 (-3.4A)NoneNoneNone | 0.88A | 1xdsB-4j8fA:undetectable | 1xdsB-4j8fA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j9v | POTASSIUM UPTAKEPROTEIN TRKA (Vibrioparahaemolyticus) |
PF02080(TrkA_C)PF02254(TrkA_N) | 5 | GLY A 239GLY A 240GLU A 261ASP A 283ASN A 306 | AGS A 502 (-3.3A)AGS A 502 ( 4.9A)AGS A 502 (-2.4A)AGS A 502 (-2.9A)AGS A 502 (-2.8A) | 1.08A | 1xdsB-4j9vA:7.4 | 1xdsB-4j9vA:26.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kpu | ELECTRON TRANSFERFLAVOPROTEINALPHA/BETA-SUBUNIT (Acidaminococcusfermentans) |
PF01012(ETF) | 5 | GLY B 218LEU B 211PHE B 89SER B 98ASN B 103 | None | 1.01A | 1xdsB-4kpuB:undetectable | 1xdsB-4kpuB:22.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kvf | RHAMNOSE ABCTRANSPORTER,PERIPLASMICRHAMNOSE-BINDINGPROTEIN (Kribbellaflavida) |
PF13407(Peripla_BP_4) | 5 | GLY A 306GLY A 82GLY A 80ASP A 149ASN A 301 | None | 1.01A | 1xdsB-4kvfA:2.9 | 1xdsB-4kvfA:21.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n7w | TRANSPORTER,SODIUM/BILE ACIDSYMPORTER FAMILY (Yersiniafrederiksenii) |
PF01758(SBF) | 5 | GLY A 238GLY A 237GLY A 234ASP A 244PHE A 243 | None | 1.15A | 1xdsB-4n7wA:undetectable | 1xdsB-4n7wA:23.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4om9 | SERINE PROTEASE PET (Escherichiacoli) |
PF02395(Peptidase_S6) | 5 | GLY A 429GLY A 428GLY A 402ASP A 432ASN A 476 | None | 1.16A | 1xdsB-4om9A:undetectable | 1xdsB-4om9A:17.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pgh | CAFFEIC ACIDO-METHYLTRANSFERASE (Sorghum bicolor) |
PF00891(Methyltransf_2)PF08100(Dimerisation) | 6 | GLY A 206GLY A 207GLY A 208LEU A 230ASP A 249TRP A 269 | SAM A 401 (-3.8A)SAM A 401 ( 3.9A)SAM A 401 ( 4.1A)SAM A 401 (-4.3A)SAM A 401 (-3.2A)None | 0.42A | 1xdsB-4pghA:24.8 | 1xdsB-4pghA:27.97 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4qvg | SIBL (Streptosporangiumsibiricum) |
PF00891(Methyltransf_2)PF16864(Dimerisation2) | 5 | GLY A 178GLY A 179GLY A 180ASP A 228TRP A 250 | None | 0.51A | 1xdsB-4qvgA:23.1 | 1xdsB-4qvgA:30.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r70 | BACTERIOPHYTOCHROME(LIGHT-REGULATEDSIGNAL TRANSDUCTIONHISTIDINE KINASE),PHYB2 (Rhodopseudomonaspalustris) |
PF00360(PHY)PF01590(GAF)PF08446(PAS_2) | 5 | GLY A 462GLY A 463ASP A 209PHE A 210SER A 483 | None | 1.16A | 1xdsB-4r70A:undetectable | 1xdsB-4r70A:23.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uoe | SPERMIDINE SYNTHASE (Plasmodiumfalciparum) |
PF01564(Spermine_synth)PF17284(Spermine_synt_N) | 5 | GLY A 124GLY A 125GLY A 126GLU A 147ASP A 178 | MTA A 401 (-3.5A)MTA A 401 (-3.8A)MTA A 401 ( 4.5A)MTA A 401 (-2.7A)MTA A 401 (-3.2A) | 0.76A | 1xdsB-4uoeA:10.9 | 1xdsB-4uoeA:18.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y6o | NAD-DEPENDENTPROTEIN DEACETYLASESIRTUIN-2 (Homo sapiens) |
PF02146(SIR2) | 5 | GLY A 305GLY A 304ASP A 310PHE A 309ASN A 286 | None | 0.91A | 1xdsB-4y6oA:4.4 | 1xdsB-4y6oA:21.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z42 | UREASE SUBUNIT BETAUREASE SUBUNIT ALPHA (Yersiniaenterocolitica;Yersiniaenterocolitica) |
PF00699(Urease_beta)PF00449(Urease_alpha)PF01979(Amidohydro_1) | 5 | GLY B 39GLY B 38ASP C 401PHE C 29ASN B 34 | None | 1.16A | 1xdsB-4z42B:undetectable | 1xdsB-4z42B:19.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cvv | (ISO)EUGENOLO-METHYLTRANSFERASE (Clarkia breweri) |
PF00891(Methyltransf_2)PF08100(Dimerisation) | 7 | TRP A 166GLY A 211GLY A 212GLY A 213LEU A 235ASP A 254TRP A 274 | SAH A 401 ( 3.6A)SAH A 401 (-3.8A)SAH A 401 ( 4.2A)SAH A 401 ( 3.7A)SAH A 401 (-4.3A)SAH A 401 (-3.5A)None | 0.51A | 1xdsB-5cvvA:26.8 | 1xdsB-5cvvA:25.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5di0 | NATTERIN-LIKEPROTEIN (Danio rerio) |
PF03318(ETX_MTX2) | 5 | GLY A 130GLY A 15GLY A 14PHE A 18SER A 132 | PEG A 406 (-3.5A)PGE A 413 ( 4.9A)NonePEG A 406 (-4.9A)PGE A 413 (-3.5A) | 1.09A | 1xdsB-5di0A:undetectable | 1xdsB-5di0A:19.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dtr | HISTONE-LYSINEN-METHYLTRANSFERASE,H3 LYSINE-79SPECIFIC (Homo sapiens) |
PF08123(DOT1) | 5 | GLY A 163GLY A 165GLU A 186ASP A 222PHE A 223 | None | 0.78A | 1xdsB-5dtrA:10.7 | 1xdsB-5dtrA:24.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dtr | HISTONE-LYSINEN-METHYLTRANSFERASE,H3 LYSINE-79SPECIFIC (Homo sapiens) |
PF08123(DOT1) | 5 | GLY A 163GLY A 165GLU A 186PRO A 191ASP A 222 | None | 0.75A | 1xdsB-5dtrA:10.7 | 1xdsB-5dtrA:24.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ee7 | GLUCAGONRECEPTOR,ENDOLYSIN,GLUCAGON RECEPTOR (Homo sapiens;Escherichiavirus T4) |
PF00002(7tm_2)PF00959(Phage_lysozyme) | 5 | GLY A 164GLY A 165LEU A 160SER A 167ASN A 174 | NoneNoneOLA A1207 ( 4.0A)NoneNone | 1.06A | 1xdsB-5ee7A:undetectable | 1xdsB-5ee7A:22.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fif | CARBOXYLASE (Deinococcusradiodurans) |
PF01039(Carboxyl_trans) | 5 | GLY A 160GLY A 159GLY A 158LEU A 206ASN A 134 | None | 1.07A | 1xdsB-5fifA:undetectable | 1xdsB-5fifA:25.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fpn | HEAT SHOCK-RELATED70 KDA PROTEIN 2 (Homo sapiens) |
PF00012(HSP70) | 5 | GLY A 232GLY A 204GLY A 205LEU A 230ASN A 237 | None | 0.94A | 1xdsB-5fpnA:undetectable | 1xdsB-5fpnA:19.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i2h | O-METHYLTRANSFERASEFAMILY 2 (Planctopiruslimnophila) |
PF00891(Methyltransf_2)PF16864(Dimerisation2) | 5 | GLY A 202GLY A 203ASP A 251SER A 266TRP A 272 | NoneNoneEDO A 504 (-3.8A)NoneNone | 0.68A | 1xdsB-5i2hA:14.0 | 1xdsB-5i2hA:26.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ic7 | PUTATIVEUNCHARACTERIZEDPROTEIN (Chaetomiumthermophilum) |
no annotation | 5 | GLY A 473GLY A 479GLY A 478LEU A 500ASP A 499 | None | 1.16A | 1xdsB-5ic7A:undetectable | 1xdsB-5ic7A:23.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j44 | SERINE PROTEASE SEPAAUTOTRANSPORTER (Shigellaflexneri) |
PF02395(Peptidase_S6) | 5 | GLY A 147GLY A 148GLY A 149LEU A 231ASN A 204 | None | 1.11A | 1xdsB-5j44A:undetectable | 1xdsB-5j44A:17.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j44 | SERINE PROTEASE SEPAAUTOTRANSPORTER (Shigellaflexneri) |
PF02395(Peptidase_S6) | 5 | GLY A 326GLY A 347GLY A 346ASP A 258SER A 113 | None | 0.77A | 1xdsB-5j44A:undetectable | 1xdsB-5j44A:17.66 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5jr3 | CARMINOMYCIN4-O-METHYLTRANSFERASE DNRK (Streptomycespeucetius) |
PF00891(Methyltransf_2) | 9 | GLY A 187GLY A 188GLY A 189GLU A 210ASP A 237PHE A 238SER A 252ASN A 257TRP A 258 | SAH A 401 (-3.9A)SAH A 401 ( 3.7A)SAH A 401 ( 3.8A)SAH A 401 (-2.8A)SAH A 401 (-3.7A)SAH A 401 (-3.4A)SAH A 401 (-2.6A)SAH A 401 (-4.2A)None | 0.33A | 1xdsB-5jr3A:34.5 | 1xdsB-5jr3A:53.30 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5jr3 | CARMINOMYCIN4-O-METHYLTRANSFERASE DNRK (Streptomycespeucetius) |
PF00891(Methyltransf_2) | 6 | GLY A 188GLU A 210ASP A 237PHE A 238ASN A 257TRP A 258 | SAH A 401 ( 3.7A)SAH A 401 (-2.8A)SAH A 401 (-3.7A)SAH A 401 (-3.4A)SAH A 401 (-4.2A)None | 1.03A | 1xdsB-5jr3A:34.5 | 1xdsB-5jr3A:53.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o3z | SORBITOL-6-PHOSPHATEDEHYDROGENASE (Erwiniaamylovora) |
no annotation | 5 | GLY A 9GLY A 10GLY A 11LEU A 34ASP A 61 | None | 0.91A | 1xdsB-5o3zA:7.0 | 1xdsB-5o3zA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5obu | CHAPERONE PROTEINDNAK (Mycoplasmagenitalium) |
no annotation | 5 | GLY A 208GLY A 180GLY A 181LEU A 206ASN A 213 | ANP A 602 (-3.3A)ANP A 602 (-3.4A)ANP A 602 (-3.5A)NoneNone | 0.85A | 1xdsB-5obuA:undetectable | 1xdsB-5obuA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5obw | CHAPERONE PROTEINDNAK (Mycoplasmagenitalium) |
no annotation | 5 | GLY A 208GLY A 180GLY A 181LEU A 206ASN A 213 | ADP A 402 (-3.3A)ADP A 402 (-3.5A)NoneNoneNone | 0.89A | 1xdsB-5obwA:undetectable | 1xdsB-5obwA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t57 | SEMIALDEHYDEDEHYDROGENASENAD-BINDING PROTEIN (Cupriavidusnecator) |
PF03807(F420_oxidored)PF16896(PGDH_C) | 5 | GLY A 137GLY A 136GLY A 135PRO A 118ASP A 126 | None | 0.93A | 1xdsB-5t57A:5.6 | 1xdsB-5t57A:26.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tch | TRYPTOPHAN SYNTHASEBETA CHAIN (Mycobacteriumtuberculosis) |
PF00291(PALP) | 5 | GLY B 17GLY B 27GLY B 26PRO B 325ASP B 12 | None | 1.06A | 1xdsB-5tchB:undetectable | 1xdsB-5tchB:25.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w3l | C5 ANTIBODY VARIABLEHEAVY DOMAINC5 ANTIBODY VARIABLELIGHT DOMAIN (Mus musculus;Mus musculus) |
PF07686(V-set)PF07686(V-set) | 5 | GLY G 101GLY G 100GLY G 99LEU E 45SER G 7 | None | 1.03A | 1xdsB-5w3lG:undetectable | 1xdsB-5w3lG:15.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wcj | METHYLTRANSFERASE-LIKE PROTEIN 13 (Homo sapiens) |
PF01564(Spermine_synth) | 5 | GLY A 505GLY A 504GLY A 503LEU A 530PHE A 539 | NoneNoneSAH A 705 (-3.6A)NoneNone | 1.08A | 1xdsB-5wcjA:12.2 | 1xdsB-5wcjA:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xez | GLUCAGONRECEPTOR,ENDOLYSIN,GLUCAGON RECEPTOR (Homo sapiens;Escherichiavirus T4) |
PF00002(7tm_2)PF00959(Phage_lysozyme)PF02793(HRM) | 5 | GLY A 164GLY A 165LEU A 160SER A 167ASN A 174 | None | 1.09A | 1xdsB-5xezA:undetectable | 1xdsB-5xezA:21.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xoh | BERGAPTOLO-METHYLTRANSFERASE (Peucedanumpraeruptorum) |
no annotation | 6 | GLY A 203GLY A 204GLY A 205LEU A 227ASP A 246TRP A 266 | SAH A 401 (-3.4A)SAH A 401 ( 3.9A)SAH A 401 ( 3.7A)SAH A 401 (-4.1A)SAH A 401 (-3.7A)None | 0.33A | 1xdsB-5xohA:24.5 | 1xdsB-5xohA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yy5 | (;) |
no annotationno annotation | 5 | GLY D 104GLY D 103GLY D 102LEU C 45SER D 7 | None | 1.16A | 1xdsB-5yy5D:undetectable | 1xdsB-5yy5D:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c5b | METHYLTRANSFERASE (Lysobacterantibioticus) |
no annotation | 6 | GLY A 182GLY A 184ASP A 232PHE A 233SER A 247TRP A 253 | SAH A 501 (-4.0A)SAH A 501 (-3.3A)SAH A 501 (-3.5A)SAH A 501 (-3.5A)SAH A 501 (-2.8A)None | 0.25A | 1xdsB-6c5bA:29.6 | 1xdsB-6c5bA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gun | - (-) |
no annotation | 5 | GLY A 80GLY A 81GLY A 82PRO A 51SER A 73 | None | 1.05A | 1xdsB-6gunA:undetectable | 1xdsB-6gunA:undetectable |