SIMILAR PATTERNS OF AMINO ACIDS FOR 1XDK_F_9CRF1600

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bry BRYODIN I

(Bryonia dioica) 		PF00161
(RIP) 		5 LEU Y 139
LEU Y 154
ILE Y 155
PHE Y  83
LEU Y 105
 None
 1.01A 1xdkF-1bryY:
0.1		 1xdkF-1bryY:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1k ADRENODOXIN
REDUCTASE

(Bos taurus) 		PF07992
(Pyr_redox_2) 		5 LEU A 210
ILE A 194
SER A 328
LEU A 223
LEU A 245
 None
None
NAP  A 802 (-4.1A)
None
None
 0.97A 1xdkF-1e1kA:
undetectable		 1xdkF-1e1kA:
21.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1exx RETINOIC ACID
RECEPTOR GAMMA-2

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 PHE A 230
ALA A 234
CYH A 237
ILE A 275
ARG A 278
SER A 289
PHE A 304
LEU A 307
 961  A 450 (-3.9A)
961  A 450 (-3.1A)
961  A 450 (-3.6A)
961  A 450 (-3.5A)
961  A 450 (-3.6A)
961  A 450 (-2.5A)
961  A 450 (-3.6A)
961  A 450 (-4.8A)
 0.59A 1xdkF-1exxA:
37.3		 1xdkF-1exxA:
81.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1exx RETINOIC ACID
RECEPTOR GAMMA-2

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 PHE A 230
ALA A 234
CYH A 237
LEU A 268
LEU A 271
ILE A 275
ARG A 278
SER A 289
PHE A 304
 961  A 450 (-3.9A)
961  A 450 (-3.1A)
961  A 450 (-3.6A)
961  A 450 ( 4.9A)
961  A 450 (-3.6A)
961  A 450 (-3.5A)
961  A 450 (-3.6A)
961  A 450 (-2.5A)
961  A 450 (-3.6A)
 0.53A 1xdkF-1exxA:
37.3		 1xdkF-1exxA:
81.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1exx RETINOIC ACID
RECEPTOR GAMMA-2

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 PHE A 230
ALA A 234
CYH A 237
SER A 289
PHE A 304
LEU A 307
LEU A 268
 961  A 450 (-3.9A)
961  A 450 (-3.1A)
961  A 450 (-3.6A)
961  A 450 (-2.5A)
961  A 450 (-3.6A)
961  A 450 (-4.8A)
961  A 450 ( 4.9A)
 1.22A 1xdkF-1exxA:
37.3		 1xdkF-1exxA:
81.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH

(Escherichia
coli) 		PF00588
(SpoU_methylase)
PF08032
(SpoU_sub_bind) 		5 ALA A  72
LEU A  39
ILE A   8
SER A  62
LEU A  43
 None
 0.86A 1xdkF-1gz0A:
0.0		 1xdkF-1gz0A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hsj FUSION PROTEIN
CONSISTING OF
STAPHYLOCOCCUS
ACCESSORY REGULATOR
PROTEIN R AND
MALTOSE BINDING
PROTEIN

(Escherichia
coli;
Staphylococcus
aureus) 		PF01547
(SBP_bac_1) 		5 LEU A 449
LEU A 477
ILE A 474
ILE A 478
LEU A 447
 None
 0.96A 1xdkF-1hsjA:
0.0		 1xdkF-1hsjA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jv4 MAJOR URINARY
PROTEIN 2

(Mus musculus) 		PF00061
(Lipocalin) 		5 PHE A  56
LEU A 116
ILE A  32
ARG A  60
LEU A 105
 None
None
None
None
TZL  A 170 ( 4.9A)
 1.02A 1xdkF-1jv4A:
undetectable		 1xdkF-1jv4A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mg1 PROTEIN (HTLV-1 GP21
ECTODOMAIN/MALTOSE-B
INDING PROTEIN
CHIMERA)

(Primate
T-lymphotropic
virus 1) 		PF00429
(TLV_coat)
PF13416
(SBP_bac_8) 		5 LEU A 196
LEU A 199
ILE A 200
LEU A 152
LEU A 161
 None
 1.00A 1xdkF-1mg1A:
0.0		 1xdkF-1mg1A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mzg SUFE PROTEIN

(Escherichia
coli) 		PF02657
(SufE) 		5 ALA A  75
LEU A  81
ILE A  27
ILE A  28
LEU A 115
 None
 0.96A 1xdkF-1mzgA:
0.0		 1xdkF-1mzgA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nl4 PROTEIN
FARNESYLTRANSFERASE
ALPHA SUBUNIT

(Rattus
norvegicus) 		PF01239
(PPTA) 		5 LEU A 284
LEU A 280
ILE A 283
LEU A 256
LEU A 295
 None
 1.01A 1xdkF-1nl4A:
0.0		 1xdkF-1nl4A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgv TROPOMODULIN TMD-1

(Caenorhabditis
elegans) 		no annotation 5 PHE A 326
LEU A 285
ILE A 286
ILE A 289
LEU A 305
 None
 0.92A 1xdkF-1pgvA:
undetectable		 1xdkF-1pgvA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rtw TRANSCRIPTIONAL
ACTIVATOR, PUTATIVE

(Pyrococcus
furiosus) 		PF03070
(TENA_THI-4) 		5 LEU A 175
LEU A 172
ILE A 171
ILE A 168
LEU A 119
 None
 0.81A 1xdkF-1rtwA:
undetectable		 1xdkF-1rtwA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tcs TRICHOSANTHIN

(Trichosanthes
kirilowii) 		PF00161
(RIP) 		5 LEU A 139
LEU A 154
ILE A 155
PHE A  83
LEU A 105
 None
None
NDP  A 280 (-3.9A)
NDP  A 280 ( 4.8A)
None
 1.01A 1xdkF-1tcsA:
undetectable		 1xdkF-1tcsA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukf AVIRULENCE PROTEIN
AVRPPH3

(Pseudomonas
savastanoi) 		PF03543
(Peptidase_C58) 		5 LEU A 225
ILE A 244
ILE A 248
SER A 253
LEU A 202
 None
 0.90A 1xdkF-1ukfA:
undetectable		 1xdkF-1ukfA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v0b CELL DIVISION
CONTROL PROTEIN 2
HOMOLOG

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		5 ALA A 102
LEU A 261
ILE A 190
LEU A 200
LEU A 253
 None
 0.91A 1xdkF-1v0bA:
undetectable		 1xdkF-1v0bA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v8b ADENOSYLHOMOCYSTEINA
SE

(Plasmodium
falciparum) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 PHE A 405
ALA A 442
LEU A 446
ARG A  33
PHE A 401
 None
 0.93A 1xdkF-1v8bA:
undetectable		 1xdkF-1v8bA:
21.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xap RETINOIC ACID
RECEPTOR BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 PHE A 221
ALA A 225
ARG A 269
SER A 280
PHE A 295
LEU A 298
 TTB  A   1 (-4.7A)
TTB  A   1 (-4.0A)
TTB  A   1 (-3.3A)
TTB  A   1 (-3.1A)
TTB  A   1 ( 4.1A)
None
 0.63A 1xdkF-1xapA:
37.1		 1xdkF-1xapA:
92.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xap RETINOIC ACID
RECEPTOR BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 PHE A 221
ALA A 225
CYH A 228
LEU A 259
LEU A 262
ILE A 263
ILE A 266
ARG A 269
SER A 280
PHE A 295
 TTB  A   1 (-4.7A)
TTB  A   1 (-4.0A)
TTB  A   1 ( 3.8A)
TTB  A   1 ( 4.9A)
TTB  A   1 (-3.9A)
TTB  A   1 ( 4.9A)
TTB  A   1 ( 4.0A)
TTB  A   1 (-3.3A)
TTB  A   1 (-3.1A)
TTB  A   1 ( 4.1A)
 0.46A 1xdkF-1xapA:
37.1		 1xdkF-1xapA:
92.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yco BRANCHED-CHAIN
PHOSPHOTRANSACYLASE

(Enterococcus
faecalis) 		PF01515
(PTA_PTB) 		5 LEU A 266
LEU A  74
ILE A  72
LEU A  29
LEU A  17
 None
 1.02A 1xdkF-1ycoA:
undetectable		 1xdkF-1ycoA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yx1 HYPOTHETICAL PROTEIN
PA2260

(Pseudomonas
aeruginosa) 		PF01261
(AP_endonuc_2) 		5 ALA A  35
LEU A  27
LEU A  63
ILE A  58
LEU A  40
 None
 0.89A 1xdkF-1yx1A:
undetectable		 1xdkF-1yx1A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z05 TRANSCRIPTIONAL
REGULATOR, ROK
FAMILY

(Vibrio cholerae) 		PF00480
(ROK) 		5 ALA A 183
ILE A 150
ILE A 148
LEU A  96
LEU A 124
 None
 0.92A 1xdkF-1z05A:
undetectable		 1xdkF-1z05A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zyb TRANSCRIPTION
REGULATOR, CRP
FAMILY

(Bacteroides
thetaiotaomicron) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		5 PHE A 125
LEU A  88
LEU A  52
ILE A 110
LEU A 116
 None
 1.00A 1xdkF-1zybA:
undetectable		 1xdkF-1zybA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aaz THYMIDYLATE SYNTHASE

(Cryptococcus
neoformans) 		PF00303
(Thymidylat_synt) 		5 LEU A 234
ILE A 238
ILE A 241
LEU A 153
LEU A  80
 None
 0.92A 1xdkF-2aazA:
undetectable		 1xdkF-2aazA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ahq RNA POLYMERASE SIGMA
FACTOR RPON

(Aquifex
aeolicus) 		PF04552
(Sigma54_DBD) 		5 LEU A  21
LEU A  24
ILE A  25
ILE A  28
LEU A  16
 None
 0.95A 1xdkF-2ahqA:
undetectable		 1xdkF-2ahqA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ddw PYRIDOXINE KINASE

(Escherichia
coli) 		PF08543
(Phos_pyr_kin) 		5 PHE A 235
ALA A 256
LEU A 249
ILE A 219
LEU A 243
 None
 0.99A 1xdkF-2ddwA:
undetectable		 1xdkF-2ddwA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eh3 TRANSCRIPTIONAL
REGULATOR

(Aquifex
aeolicus) 		PF00440
(TetR_N) 		5 PHE A  65
ALA A 115
LEU A 142
LEU A 139
ILE A 138
 None
 0.98A 1xdkF-2eh3A:
undetectable		 1xdkF-2eh3A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hmf PROBABLE
ASPARTOKINASE

(Methanocaldococcus
jannaschii) 		PF00696
(AA_kinase)
PF01842
(ACT)
PF13840
(ACT_7) 		5 PHE A  68
ALA A  48
LEU A 132
ILE A 125
ARG A 122
 None
 1.00A 1xdkF-2hmfA:
undetectable		 1xdkF-2hmfA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnh DNA POLYMERASE III
ALPHA SUBUNIT

(Escherichia
coli) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		5 LEU A  97
LEU A 100
ILE A 101
ARG A 107
LEU A 128
 None
 0.93A 1xdkF-2hnhA:
undetectable		 1xdkF-2hnhA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8s AGR_C_984P

(Agrobacterium
fabrum) 		PF06748
(DUF1217) 		6 ALA A 206
LEU A 265
ILE A 251
ILE A 253
PHE A 215
LEU A 266
 None
 1.33A 1xdkF-2o8sA:
undetectable		 1xdkF-2o8sA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1n TRANSPORT INHIBITOR
RESPONSE 1 PROTEIN

(Arabidopsis
thaliana) 		PF12937
(F-box-like) 		5 ALA B 152
LEU B 189
ILE B 191
LEU B 203
LEU B 186
 None
 0.99A 1xdkF-2p1nB:
undetectable		 1xdkF-2p1nB:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rb9 HYPE PROTEIN

(Escherichia
coli) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 PHE A  27
ALA A  26
LEU A 109
LEU A  22
ILE A  19
 None
 1.01A 1xdkF-2rb9A:
undetectable		 1xdkF-2rb9A:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdu TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE-ASSOCI
ATED WD REPEAT
PROTEIN TRM82

(Saccharomyces
cerevisiae) 		no annotation 5 LEU B 108
ILE B  22
ILE B  23
SER B 413
LEU B 117
 None
 1.02A 1xdkF-2vduB:
undetectable		 1xdkF-2vduB:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w57 FERRIC UPTAKE
REGULATION PROTEIN

(Vibrio cholerae) 		PF01475
(FUR) 		5 LEU A  26
LEU A  23
ILE A  22
LEU A  59
LEU A  82
 None
 0.81A 1xdkF-2w57A:
undetectable		 1xdkF-2w57A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wwd 1,4-BETA-N-ACETYLMUR
AMIDASE

(Streptococcus
pneumoniae) 		PF01183
(Glyco_hydro_25)
PF01473
(CW_binding_1) 		5 ALA A 376
LEU A 415
ILE A 387
ILE A 386
LEU A 410
 None
 0.95A 1xdkF-2wwdA:
undetectable		 1xdkF-2wwdA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yyb HYPOTHETICAL PROTEIN
TTHA1606

(Thermus
thermophilus) 		PF01784
(NIF3) 		5 ALA A  45
LEU A  61
ILE A  62
LEU A  28
LEU A  86
 None
 0.90A 1xdkF-2yybA:
undetectable		 1xdkF-2yybA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a68 FERRITIN-4,
CHLOROPLASTIC

(Glycine max) 		PF00210
(Ferritin) 		6 PHE A  84
ALA A 132
ILE A 181
SER A 138
PHE A  83
LEU A 204
 None
 1.38A 1xdkF-3a68A:
undetectable		 1xdkF-3a68A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ajb PEROXISOMAL
BIOGENESIS FACTOR 3

(Homo sapiens) 		PF04882
(Peroxin-3) 		5 LEU A 205
ILE A 325
ILE A 326
SER A  86
LEU A 209
 None
 0.98A 1xdkF-3ajbA:
1.7		 1xdkF-3ajbA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b6v KINESIN-LIKE PROTEIN
KIF3C

(Homo sapiens) 		PF00225
(Kinesin) 		5 CYH A  17
LEU A  44
LEU A  33
ILE A  32
LEU A 356
 UNX  A1003 ( 4.6A)
None
None
None
None
 0.86A 1xdkF-3b6vA:
undetectable		 1xdkF-3b6vA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwh CUCURMOSIN

(Cucurbita
moschata) 		PF00161
(RIP) 		6 ALA A  62
LEU A 137
LEU A 152
ILE A 153
PHE A  83
LEU A 103
 None
None
None
EDO  A 253 ( 4.1A)
None
None
 1.29A 1xdkF-3bwhA:
undetectable		 1xdkF-3bwhA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei) 		PF00026
(Asp) 		5 PHE A 192
ALA A 194
ILE A 268
ILE A 266
LEU A 223
 None
 0.96A 1xdkF-3emyA:
undetectable		 1xdkF-3emyA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3faw RETICULOCYTE BINDING
PROTEIN

(Streptococcus
agalactiae) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 LEU A 717
ILE A 721
ILE A 724
ARG A 727
LEU A 733
 None
 1.01A 1xdkF-3fawA:
undetectable		 1xdkF-3fawA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fy5 SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-2

(Xenopus laevis) 		PF00595
(PDZ) 		5 ALA A 294
LEU A 265
ILE A 267
ILE A 286
LEU A 336
 None
 0.99A 1xdkF-3fy5A:
undetectable		 1xdkF-3fy5A:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7n NUCLEOPORIN NUP120

(Saccharomyces
cerevisiae) 		PF11715
(Nup160) 		5 LEU A 574
ILE A 579
PHE A 637
LEU A 642
LEU A 570
 None
 0.98A 1xdkF-3h7nA:
undetectable		 1xdkF-3h7nA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjw 50S RIBOSOMAL
PROTEIN L7AE

(Pyrococcus
furiosus) 		PF01248
(Ribosomal_L7Ae) 		5 PHE C  10
CYH C  71
LEU C  51
ILE C  53
ILE C  54
 None
 0.96A 1xdkF-3hjwC:
undetectable		 1xdkF-3hjwC:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihu TRANSCRIPTIONAL
REGULATOR, GNTR
FAMILY

(Cupriavidus
pinatubonensis) 		PF00392
(GntR)
PF07729
(FCD) 		5 ALA A  58
LEU A  39
ILE A  78
ILE A  67
LEU A  44
 None
 0.85A 1xdkF-3ihuA:
undetectable		 1xdkF-3ihuA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jvv TWITCHING MOBILITY
PROTEIN

(Pseudomonas
aeruginosa) 		PF00437
(T2SSE) 		5 LEU A  50
ILE A  51
ILE A  54
PHE A  96
LEU A  42
 None
 0.88A 1xdkF-3jvvA:
undetectable		 1xdkF-3jvvA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kjl SAGA-ASSOCIATED
FACTOR 11

(Saccharomyces
cerevisiae) 		no annotation 5 LEU E  20
LEU E  23
ILE E  24
ILE E  27
ARG E  30
 None
 0.89A 1xdkF-3kjlE:
undetectable		 1xdkF-3kjlE:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kvs C-PHYCOCYANIN ALPHA
CHAIN

(Galdieria
sulphuraria) 		PF00502
(Phycobilisome) 		5 ALA A 132
LEU A 161
ILE A 154
SER A 138
LEU A 111
 None
None
None
None
BLA  A 484 ( 4.3A)
 0.94A 1xdkF-3kvsA:
undetectable		 1xdkF-3kvsA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzw CYTOSOL
AMINOPEPTIDASE

(Staphylococcus
aureus) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		6 LEU A 488
ILE A 484
ILE A 481
ARG A 133
LEU A 256
LEU A 301
 None
 1.45A 1xdkF-3kzwA:
undetectable		 1xdkF-3kzwA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l0i DRRA

(Legionella
pneumophila) 		PF14860
(DrrA_P4M) 		5 LEU A 255
LEU A 252
ILE A 248
LEU A 335
LEU A 278
 None
 0.98A 1xdkF-3l0iA:
undetectable		 1xdkF-3l0iA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lov PROTOPORPHYRINOGEN
OXIDASE

(Exiguobacterium
sibiricum) 		PF01593
(Amino_oxidase) 		5 ALA A  17
LEU A  68
LEU A  71
ILE A  72
LEU A 234
 None
 0.91A 1xdkF-3lovA:
undetectable		 1xdkF-3lovA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lwj PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Syntrophomonas
wolfei) 		PF00440
(TetR_N) 		5 LEU A  62
LEU A  59
ILE A  58
SER A 116
LEU A 105
 None
 0.96A 1xdkF-3lwjA:
undetectable		 1xdkF-3lwjA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oc7 ENOYL-COA HYDRATASE

(Mycobacterium
avium) 		PF00378
(ECH_1) 		5 LEU A 159
LEU A 184
ILE A 182
SER A 135
LEU A 155
 None
 0.99A 1xdkF-3oc7A:
undetectable		 1xdkF-3oc7A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4

(Saccharomyces
cerevisiae) 		PF11701
(UNC45-central) 		5 LEU A 693
ILE A 694
ILE A 698
PHE A 718
LEU A 721
 None
 0.71A 1xdkF-3opbA:
undetectable		 1xdkF-3opbA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pih UVRABC SYSTEM
PROTEIN A

(Thermotoga
maritima) 		PF00005
(ABC_tran) 		5 LEU A 139
LEU A 136
ILE A 135
ILE A 132
LEU A 210
 None
 0.69A 1xdkF-3pihA:
undetectable		 1xdkF-3pihA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9s DNA-BINDING RESPONSE
REGULATOR

(Deinococcus
radiodurans) 		PF00072
(Response_reg)
PF00486
(Trans_reg_C) 		5 LEU A 157
LEU A 160
ILE A 161
LEU A 131
LEU A 196
 None
 0.97A 1xdkF-3q9sA:
undetectable		 1xdkF-3q9sA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qok PUTATIVE CHITINASE
II

(Klebsiella
pneumoniae) 		PF00704
(Glyco_hydro_18) 		5 LEU A 271
LEU A 219
SER A 200
LEU A 235
LEU A 389
 None
 1.00A 1xdkF-3qokA:
undetectable		 1xdkF-3qokA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N

(Escherichia
coli) 		no annotation 5 ALA N 120
LEU N 128
ILE N 132
ILE N 135
LEU N 214
 None
 1.02A 1xdkF-3rkoN:
undetectable		 1xdkF-3rkoN:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rre PUTATIVE
UNCHARACTERIZED
PROTEIN

(Thermotoga
maritima) 		PF01256
(Carb_kinase)
PF03853
(YjeF_N) 		5 LEU A 477
LEU A 480
ILE A 481
ARG A 486
LEU A 472
 None
 0.82A 1xdkF-3rreA:
undetectable		 1xdkF-3rreA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s1s RESTRICTION
ENDONUCLEASE BPUSI

(Bacillus
pumilus) 		PF02384
(N6_Mtase)
PF15516
(BpuSI_N) 		5 LEU A 279
LEU A 282
ILE A 283
ILE A 286
LEU A 266
 None
None
None
None
IOD  A 962 ( 4.6A)
 1.00A 1xdkF-3s1sA:
undetectable		 1xdkF-3s1sA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sdq ALPHA-BISABOLENE
SYNTHASE

(Abies grandis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 LEU A 163
ILE A 159
ILE A 156
LEU A 187
LEU A 201
 None
 0.96A 1xdkF-3sdqA:
undetectable		 1xdkF-3sdqA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tzg HYPOTHETICAL PROTEIN
BVU_2266

(Bacteroides
vulgatus) 		no annotation 5 LEU A  47
ILE A  55
ARG A  64
PHE A 206
LEU A 209
 None
 0.99A 1xdkF-3tzgA:
undetectable		 1xdkF-3tzgA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u41 TWIN-ARGININE
LEADER-BINDING
PROTEIN DMSD

(Escherichia
coli) 		PF02613
(Nitrate_red_del) 		5 PHE A  10
ALA A  14
LEU A 186
LEU A 193
LEU A 155
 None
 0.99A 1xdkF-3u41A:
undetectable		 1xdkF-3u41A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgj 4-HYDROXYPHENYLPYRUV
IC ACID DIOXYGENASE

(Streptomyces
coelicolor) 		PF00903
(Glyoxalase)
PF14696
(Glyoxalase_5) 		5 ALA A  22
LEU A 262
PHE A  42
LEU A  40
LEU A 337
 None
 0.94A 1xdkF-3zgjA:
undetectable		 1xdkF-3zgjA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zvk TOXIN OF
TOXIN-ANTITOXIN
SYSTEM

(Rickettsia
felis) 		PF01850
(PIN) 		6 LEU A  84
LEU A 100
ILE A 102
PHE A 121
LEU A 127
LEU A  88
 None
 1.46A 1xdkF-3zvkA:
undetectable		 1xdkF-3zvkA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4are COLLAGENASE G

(Hathewaya
histolytica) 		PF01752
(Peptidase_M9)
PF08453
(Peptidase_M9_N) 		5 PHE A 158
ALA A 195
ILE A 167
PHE A 157
LEU A 124
 None
 0.99A 1xdkF-4areA:
undetectable		 1xdkF-4areA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4din CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-BETA REGULATORY
SUBUNIT

(Homo sapiens) 		PF00027
(cNMP_binding)
PF02197
(RIIa) 		6 LEU B 329
LEU B 328
ILE B 325
ILE B 253
ARG B 370
SER B 256
 None
 1.50A 1xdkF-4dinB:
undetectable		 1xdkF-4dinB:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dq1 THYMIDYLATE SYNTHASE

(Staphylococcus
aureus) 		PF00303
(Thymidylat_synt) 		5 LEU A 239
LEU A 242
ILE A 243
LEU A 167
LEU A  64
 None
 0.91A 1xdkF-4dq1A:
undetectable		 1xdkF-4dq1A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4j ARGININE DEIMINASE

(Mycoplasma
penetrans) 		PF02274
(Amidinotransf) 		5 LEU A 371
ILE A 372
ILE A 370
LEU A 321
LEU A 318
 None
 0.93A 1xdkF-4e4jA:
undetectable		 1xdkF-4e4jA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ejs ELONGATOR COMPLEX
PROTEIN 5

(Saccharomyces
cerevisiae) 		PF10483
(Elong_Iki1) 		5 LEU B 121
ILE B 124
PHE B  80
LEU B  83
LEU B 109
 None
 1.00A 1xdkF-4ejsB:
undetectable		 1xdkF-4ejsB:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gax AMORPHA-4,11-DIENE
SYNTHASE

(Artemisia annua) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		6 ALA A 258
LEU A 294
LEU A 297
ILE A 298
ILE A 301
LEU A 339
 None
 1.48A 1xdkF-4gaxA:
undetectable		 1xdkF-4gaxA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gx8 DNA POLYMERASE III
SUBUNIT EPSILON,DNA
POLYMERASE III
SUBUNIT ALPHA

(Escherichia
coli) 		PF02811
(PHP) 		5 LEU A 142
LEU A 145
ILE A 146
ARG A 152
LEU A 173
 None
 0.93A 1xdkF-4gx8A:
undetectable		 1xdkF-4gx8A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hz8 BETA-GLUCOSIDASE

(uncultured
bacterium) 		PF00232
(Glyco_hydro_1) 		5 LEU A 289
LEU A 292
ILE A 293
LEU A 381
LEU A 259
 None
 0.93A 1xdkF-4hz8A:
undetectable		 1xdkF-4hz8A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4itm TETRAACYLDISACCHARID
E 4'-KINASE

(Aquifex
aeolicus) 		PF02606
(LpxK) 		5 LEU A 306
LEU A 309
ILE A 310
ILE A 313
LEU A  58
 None
 0.95A 1xdkF-4itmA:
undetectable		 1xdkF-4itmA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jlz UNCHARACTERIZED
PROTEIN

(Sus scrofa) 		PF03281
(Mab-21) 		5 ALA A 248
LEU A 246
ILE A 245
LEU A 214
LEU A 301
 None
 0.88A 1xdkF-4jlzA:
undetectable		 1xdkF-4jlzA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ka8 OLIGOPEPTIDASE A

(Arabidopsis
thaliana) 		PF01432
(Peptidase_M3) 		6 ALA A 710
LEU A 663
SER A 715
PHE A 701
LEU A 698
LEU A 359
 None
 1.30A 1xdkF-4ka8A:
undetectable		 1xdkF-4ka8A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kbm RNA
POLYMERASE-BINDING
TRANSCRIPTION FACTOR
CARD

(Mycobacterium
tuberculosis) 		PF02559
(CarD_CdnL_TRCF) 		5 ALA B 142
LEU B 135
ILE B 153
PHE B  71
LEU B  74
 None
 0.71A 1xdkF-4kbmB:
undetectable		 1xdkF-4kbmB:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l8j PUTATIVE EFFLUX
TRANSPORTER

(Bacteroides
eggerthii) 		PF16576
(HlyD_D23) 		5 ALA A 155
LEU A  59
ILE A 178
ARG A  62
LEU A  70
 None
 0.95A 1xdkF-4l8jA:
undetectable		 1xdkF-4l8jA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 556
ILE A 552
ILE A 576
LEU A 567
LEU A 562
 None
 1.01A 1xdkF-4m7eA:
undetectable		 1xdkF-4m7eA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nhy 2-OXOGLUTARATE AND
IRON-DEPENDENT
OXYGENASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF10637
(Ofd1_CTDD)
PF13661
(2OG-FeII_Oxy_4) 		5 LEU A 168
ILE A 233
ILE A 167
LEU A 231
LEU A  76
 None
None
PD2  A 603 ( 4.2A)
None
None
 0.99A 1xdkF-4nhyA:
undetectable		 1xdkF-4nhyA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pf1 PEPTIDASE
S15/COCE/NOND

(Thaumarchaeota
archaeon SCGC
AB-539-E09) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		5 LEU A 403
ILE A 619
PHE A 563
LEU A 479
LEU A 411
 None
 0.75A 1xdkF-4pf1A:
undetectable		 1xdkF-4pf1A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pl0 MICROCIN-J25 EXPORT
ATP-BINDING/PERMEASE
PROTEIN MCJD

(Escherichia
coli) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		5 ILE A 391
ILE A 402
ARG A 410
LEU A 368
LEU A 551
 None
 1.00A 1xdkF-4pl0A:
undetectable		 1xdkF-4pl0A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxq D-GLUCURONYL C5
EPIMERASE B

(Danio rerio) 		PF06662
(C5-epim_C) 		5 LEU A 513
LEU A 484
ILE A 481
ILE A 485
LEU A 554
 None
 1.01A 1xdkF-4pxqA:
undetectable		 1xdkF-4pxqA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdi UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D-ALANINE LIGASE

(Acinetobacter
baumannii) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 PHE A 338
LEU A 428
LEU A 431
ILE A 432
LEU A 458
 None
 0.96A 1xdkF-4qdiA:
undetectable		 1xdkF-4qdiA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rr5 MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Synechocystis
sp. PCC 6803) 		PF00698
(Acyl_transf_1) 		5 LEU A  73
LEU A  70
ILE A  69
ILE A  66
LEU A 290
 None
 0.99A 1xdkF-4rr5A:
undetectable		 1xdkF-4rr5A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ufs LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5

(Homo sapiens) 		PF00560
(LRR_1)
PF01462
(LRRNT)
PF13855
(LRR_8) 		5 PHE A 206
LEU A 241
ILE A 198
LEU A 225
LEU A 239
 None
 1.01A 1xdkF-4ufsA:
undetectable		 1xdkF-4ufsA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4umf 3-DEOXY-D-MANNO-OCTU
LOSONATE 8-PHOSPHATE
PHOSPHATASE KDSC

(Moraxella
catarrhalis) 		PF00702
(Hydrolase) 		5 ALA A  58
LEU A  13
ILE A  11
ILE A  55
LEU A  91
 None
 1.01A 1xdkF-4umfA:
undetectable		 1xdkF-4umfA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uxv SEPTATION RING
FORMATION REGULATOR
EZRA

(Bacillus
subtilis) 		PF06160
(EzrA) 		5 LEU A 419
LEU A 422
ILE A 426
SER A 488
LEU A 477
 None
 0.90A 1xdkF-4uxvA:
undetectable		 1xdkF-4uxvA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uy6 HISTIDINE-SPECIFIC
METHYLTRANSFERASE
EGTD

(Mycolicibacterium
smegmatis) 		PF10017
(Methyltransf_33) 		5 ALA A  76
LEU A 190
LEU A 318
LEU A  66
LEU A 156
 None
 1.02A 1xdkF-4uy6A:
undetectable		 1xdkF-4uy6A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjg HAPTOGLOBIN

(Homo sapiens) 		no annotation 6 ALA C 173
LEU C 187
ILE C 188
SER C 278
LEU C 245
LEU C 248
 None
 1.24A 1xdkF-4wjgC:
undetectable		 1xdkF-4wjgC:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 2
ORIGIN RECOGNITION
COMPLEX SUBUNIT 3

(Drosophila
melanogaster) 		PF04084
(ORC2)
PF07034
(ORC3_N) 		6 PHE B 483
ALA B 455
ILE B 390
ARG C 135
LEU B 442
LEU B 432
 None
 1.09A 1xdkF-4xgcB:
undetectable		 1xdkF-4xgcB:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgt FRQ-INTERACTING RNA
HELICASE

(Neurospora
crassa) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		5 ALA A 481
LEU A 502
ILE A 498
ILE A 495
LEU A 524
 None
 0.92A 1xdkF-4xgtA:
undetectable		 1xdkF-4xgtA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhc ALPHA-L-RHAMNOSIDASE

(Klebsiella
oxytoca) 		PF17389
(Bac_rhamnosid6H) 		5 PHE A 282
ALA A 351
LEU A 384
ARG A 231
LEU A 320
 None
 0.91A 1xdkF-4xhcA:
undetectable		 1xdkF-4xhcA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xll DJ-1 FAMILY PROTEIN

(Toxoplasma
gondii) 		PF01965
(DJ-1_PfpI) 		6 ALA A  30
LEU A 164
LEU A  25
ILE A  21
ILE A  22
LEU A 168
 None
 1.40A 1xdkF-4xllA:
undetectable		 1xdkF-4xllA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y07 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2

(Homo sapiens) 		PF00632
(HECT) 		6 PHE A 724
LEU A 745
LEU A 749
SER A 568
PHE A 630
LEU A 737
 None
 1.32A 1xdkF-4y07A:
undetectable		 1xdkF-4y07A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynq THREE-PRIME REPAIR
EXONUCLEASE 1

(Mus musculus) 		no annotation 6 PHE A 226
LEU A  36
LEU A  17
ILE A  15
LEU A 112
LEU A  34
 None
 1.40A 1xdkF-4ynqA:
undetectable		 1xdkF-4ynqA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0c TOLL-LIKE RECEPTOR
13

(Mus musculus) 		PF00560
(LRR_1)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 PHE A 589
LEU A 626
ILE A 607
ILE A 576
PHE A 614
 None
 0.89A 1xdkF-4z0cA:
undetectable		 1xdkF-4z0cA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z61 PHYTOSULFOKINE
RECEPTOR 1

(Daucus carota) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 PHE A 411
LEU A 396
LEU A 393
ILE A 395
LEU A 405
 None
 1.01A 1xdkF-4z61A:
undetectable		 1xdkF-4z61A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aj8 CITRATE SYNTHASE

(Pyrococcus
furiosus) 		PF00285
(Citrate_synt) 		3 LEU A 317
PHE A 288
ARG A 273
 None
 0.74A 1xdkF-1aj8A:
0.0		 1xdkF-1aj8A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bs0 PROTEIN
(8-AMINO-7-OXONANOAT
E SYNTHASE)

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		3 LEU A 276
PHE A 234
ARG A 101
 None
 0.82A 1xdkF-1bs0A:
undetectable		 1xdkF-1bs0A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6m DNA TOPOISOMERASE
III

(Escherichia
coli) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		3 LEU A 205
PHE A 506
ARG A 489
 None
 0.82A 1xdkF-1d6mA:
undetectable		 1xdkF-1d6mA:
18.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1exx RETINOIC ACID
RECEPTOR GAMMA-2

(Homo sapiens) 		PF00104
(Hormone_recep) 		3 LEU A 233
PHE A 288
ARG A 396
 961  A 450 ( 4.0A)
961  A 450 (-4.6A)
None
 0.45A 1xdkF-1exxA:
37.3		 1xdkF-1exxA:
81.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f3b GLUTATHIONE
S-TRANSFERASE YA
CHAIN

(Mus musculus) 		PF00043
(GST_C)
PF02798
(GST_N) 		3 LEU A 159
PHE A 135
ARG A  68
 None
 0.84A 1xdkF-1f3bA:
0.0		 1xdkF-1f3bA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fiq XANTHINE OXIDASE

(Bos taurus) 		PF00111
(Fer2)
PF01799
(Fer2_2) 		3 LEU A   6
PHE A   8
ARG A  32
 None
 0.83A 1xdkF-1fiqA:
undetectable		 1xdkF-1fiqA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gm5 RECG

(Thermotoga
maritima) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF17190
(RecG_N)
PF17191
(RecG_wedge) 		3 LEU A 671
PHE A 708
ARG A 680
 None
 0.85A 1xdkF-1gm5A:
undetectable		 1xdkF-1gm5A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lcy HTRA2 SERINE
PROTEASE

(Homo sapiens) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		3 LEU A 133
PHE A 170
ARG A  74
 None
 0.85A 1xdkF-1lcyA:
undetectable		 1xdkF-1lcyA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pjm IMPORTIN ALPHA-2
SUBUNIT

(Mus musculus) 		PF00514
(Arm)
PF16186
(Arm_3) 		3 LEU B 144
PHE B 124
ARG B 106
 None
 0.63A 1xdkF-1pjmB:
0.2		 1xdkF-1pjmB:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sk7 HYPOTHETICAL PROTEIN
PA-HO

(Pseudomonas
aeruginosa) 		PF01126
(Heme_oxygenase) 		3 LEU A 138
PHE A  45
ARG A 154
 None
 0.85A 1xdkF-1sk7A:
undetectable		 1xdkF-1sk7A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1taq TAQ DNA POLYMERASE

(Thermus
aquaticus) 		PF00476
(DNA_pol_A)
PF01367
(5_3_exonuc)
PF02739
(5_3_exonuc_N)
PF09281
(Taq-exonuc) 		3 LEU A 574
PHE A 564
ARG A 595
 None
 0.61A 1xdkF-1taqA:
undetectable		 1xdkF-1taqA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v43 SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN

(Pyrococcus
horikoshii) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		3 LEU A 260
PHE A 287
ARG A 310
 None
 0.69A 1xdkF-1v43A:
undetectable		 1xdkF-1v43A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)

(Thermus
thermophilus) 		PF02347
(GDC-P) 		3 LEU B 325
PHE B 324
ARG B 335
 None
 0.85A 1xdkF-1wytB:
undetectable		 1xdkF-1wytB:
20.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xap RETINOIC ACID
RECEPTOR BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		3 LEU A 224
PHE A 279
ARG A 387
 TTB  A   1 (-4.4A)
TTB  A   1 (-4.6A)
None
 0.21A 1xdkF-1xapA:
37.1		 1xdkF-1xapA:
92.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zrt CYTOCHROME C1

(Rhodobacter
capsulatus) 		PF02167
(Cytochrom_C1) 		3 LEU D  23
PHE D 212
ARG D  46
 None
 0.85A 1xdkF-1zrtD:
undetectable		 1xdkF-1zrtD:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2crp REGULATOR OF
G-PROTEIN SIGNALING
5

(Homo sapiens) 		PF00615
(RGS) 		3 LEU A  32
PHE A  42
ARG A 121
 None
 0.81A 1xdkF-2crpA:
undetectable		 1xdkF-2crpA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dc1 L-ASPARTATE
DEHYDROGENASE

(Archaeoglobus
fulgidus) 		PF01958
(DUF108)
PF03447
(NAD_binding_3) 		3 LEU A  91
PHE A  85
ARG A 103
 None
 0.82A 1xdkF-2dc1A:
undetectable		 1xdkF-2dc1A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hst EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1

(Homo sapiens) 		PF03464
(eRF1_2) 		3 LEU A 212
PHE A 158
ARG A 203
 None
 0.86A 1xdkF-2hstA:
undetectable		 1xdkF-2hstA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iqc FANCONI ANEMIA GROUP
F PROTEIN

(Homo sapiens) 		PF11107
(FANCF) 		3 LEU A 196
PHE A 201
ARG A 187
 None
 0.71A 1xdkF-2iqcA:
undetectable		 1xdkF-2iqcA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iw0 CHITIN DEACETYLASE

(Colletotrichum
lindemuthianum) 		PF01522
(Polysacc_deac_1) 		3 LEU A 220
PHE A 188
ARG A 230
 None
 0.64A 1xdkF-2iw0A:
undetectable		 1xdkF-2iw0A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iy4 NON-HEME
IRON-CONTAINING
FERRITIN

(Listeria
monocytogenes) 		PF00210
(Ferritin) 		3 LEU A 119
PHE A  12
ARG A 110
 None
 0.73A 1xdkF-2iy4A:
undetectable		 1xdkF-2iy4A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kfu RV1827 PTHR 22

(Mycobacterium
tuberculosis) 		PF00498
(FHA) 		3 LEU A  58
PHE A 146
ARG A 123
 None
 0.78A 1xdkF-2kfuA:
undetectable		 1xdkF-2kfuA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o26 KIT LIGAND
MAST/STEM CELL
GROWTH FACTOR
RECEPTOR

(Mus musculus) 		PF02404
(SCF)
no annotation 		3 LEU X 125
PHE X 201
ARG A 104
 None
 0.66A 1xdkF-2o26X:
undetectable		 1xdkF-2o26X:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ohf GTP-BINDING PROTEIN
9

(Homo sapiens) 		PF01926
(MMR_HSR1)
PF06071
(YchF-GTPase_C) 		3 LEU A  88
PHE A 300
ARG A 317
 None
 0.85A 1xdkF-2ohfA:
undetectable		 1xdkF-2ohfA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ok8 PUTATIVE
FERREDOXIN--NADP
REDUCTASE

(Plasmodium
falciparum) 		PF00175
(NAD_binding_1) 		3 LEU A  16
PHE A  46
ARG A  98
 None
 0.82A 1xdkF-2ok8A:
undetectable		 1xdkF-2ok8A:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p5x N-ACETYLSEROTONIN
O-METHYLTRANSFERASE-
LIKE PROTEIN

(Homo sapiens) 		PF02545
(Maf) 		3 LEU A  33
PHE A  35
ARG A  23
 None
 0.82A 1xdkF-2p5xA:
undetectable		 1xdkF-2p5xA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pok PEPTIDASE,
M20/M25/M40 FAMILY

(Streptococcus
pneumoniae) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		3 LEU A 296
PHE A 295
ARG A 334
 None
 0.82A 1xdkF-2pokA:
undetectable		 1xdkF-2pokA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qdj RETINOBLASTOMA-ASSOC
IATED PROTEIN

(Homo sapiens) 		PF11934
(DUF3452) 		3 LEU A  64
PHE A 115
ARG A  73
 None
 0.63A 1xdkF-2qdjA:
2.5		 1xdkF-2qdjA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qv2 INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1

(Homo sapiens) 		PF00620
(RhoGAP) 		3 LEU A 310
PHE A 331
ARG A 274
 LEU  A 310 ( 0.6A)
PHE  A 331 ( 1.3A)
ARG  A 274 ( 0.6A)
 0.72A 1xdkF-2qv2A:
undetectable		 1xdkF-2qv2A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rch CYTOCHROME P450 74A

(Arabidopsis
thaliana) 		PF00067
(p450) 		3 LEU A 221
PHE A 220
ARG A 179
 None
 0.84A 1xdkF-2rchA:
undetectable		 1xdkF-2rchA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vjw GAF FAMILY PROTEIN

(Mycolicibacterium
smegmatis) 		PF01590
(GAF) 		3 LEU A 247
PHE A 355
ARG A 238
 None
 0.80A 1xdkF-2vjwA:
undetectable		 1xdkF-2vjwA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3a PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT BETA ISOFORM

(Mus musculus) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B) 		3 LEU A 242
PHE A 275
ARG A 662
 None
 0.79A 1xdkF-2y3aA:
undetectable		 1xdkF-2y3aA:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y6i COLLAGENASE

(Hathewaya
histolytica) 		PF01752
(Peptidase_M9)
PF08453
(Peptidase_M9_N) 		3 LEU A 617
PHE A 625
ARG A 573
 None
 0.76A 1xdkF-2y6iA:
undetectable		 1xdkF-2y6iA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yik ENDOGLUCANASE

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9) 		3 LEU A 100
PHE A 170
ARG A  78
 None
 0.63A 1xdkF-2yikA:
undetectable		 1xdkF-2yikA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yuj UBIQUITIN FUSION
DEGRADATION 1-LIKE

(Homo sapiens) 		PF03152
(UFD1) 		3 LEU A  50
PHE A  82
ARG A  15
 None
 0.71A 1xdkF-2yujA:
undetectable		 1xdkF-2yujA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3boh CADMIUM-SPECIFIC
CARBONIC ANHYDRASE

(Conticribra
weissflogii) 		no annotation 3 LEU A  85
PHE A 136
ARG A  80
 None
 0.80A 1xdkF-3bohA:
undetectable		 1xdkF-3bohA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bpo INTERLEUKIN-13
RECEPTOR ALPHA-1
CHAIN

(Homo sapiens) 		PF09240
(IL6Ra-bind) 		3 LEU C 258
PHE C 253
ARG C 225
 LEU  C 258 ( 0.5A)
PHE  C 253 ( 1.3A)
ARG  C 225 ( 0.6A)
 0.76A 1xdkF-3bpoC:
undetectable		 1xdkF-3bpoC:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddd PUTATIVE
ACETYLTRANSFERASE

(Pyrococcus
horikoshii) 		PF00583
(Acetyltransf_1) 		3 LEU A 114
PHE A  89
ARG A 246
 COA  A 300 (-4.1A)
None
None
 0.68A 1xdkF-3dddA:
undetectable		 1xdkF-3dddA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hoc FILAMIN-A

(Homo sapiens) 		PF00307
(CH) 		3 LEU A 201
PHE A 264
ARG A 226
 None
 0.70A 1xdkF-3hocA:
undetectable		 1xdkF-3hocA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j5y EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1

(Homo sapiens) 		PF03463
(eRF1_1)
PF03464
(eRF1_2)
PF03465
(eRF1_3) 		3 LEU A 212
PHE A 158
ARG A 203
 None
 0.77A 1xdkF-3j5yA:
undetectable		 1xdkF-3j5yA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcm PRE-MRNA-SPLICING
FACTOR 6

(Saccharomyces
cerevisiae) 		PF06424
(PRP1_N) 		3 LEU G 780
PHE G 781
ARG G 800
 None
 0.76A 1xdkF-3jcmG:
undetectable		 1xdkF-3jcmG:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksm ABC-TYPE SUGAR
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT

(Hahella
chejuensis) 		PF13407
(Peripla_BP_4) 		3 LEU A 170
PHE A 187
ARG A 166
 None
 0.82A 1xdkF-3ksmA:
undetectable		 1xdkF-3ksmA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m8f PUTATIVE DNA-BINDING
PROTEIN

(Bacillus
thuringiensis) 		no annotation 3 LEU A  83
PHE A  31
ARG A  74
 None
 0.85A 1xdkF-3m8fA:
undetectable		 1xdkF-3m8fA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvy XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF00111
(Fer2)
PF01799
(Fer2_2) 		3 LEU A   6
PHE A   8
ARG A  32
 None
 0.85A 1xdkF-3nvyA:
undetectable		 1xdkF-3nvyA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8c NCK-ASSOCIATED
PROTEIN 1

(Homo sapiens) 		PF09735
(Nckap1) 		3 LEU B  28
PHE B 296
ARG B 588
 None
 0.83A 1xdkF-3p8cB:
3.5		 1xdkF-3p8cB:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qwm IQ MOTIF AND SEC7
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF16453
(IQ_SEC7_PH) 		3 LEU A 745
PHE A 828
ARG A 789
 None
 0.71A 1xdkF-3qwmA:
undetectable		 1xdkF-3qwmA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3srz TOXIN A

(Clostridioides
difficile) 		PF12918
(TcdB_N)
PF12919
(TcdA_TcdB) 		3 LEU A 446
PHE A 445
ARG A 261
 None
 0.70A 1xdkF-3srzA:
undetectable		 1xdkF-3srzA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uk8 CADMIUM-SPECIFIC
CARBONIC ANHYDRASE

(Conticribra
weissflogii) 		no annotation 3 LEU A 505
PHE A 556
ARG A 500
 None
 0.86A 1xdkF-3uk8A:
undetectable		 1xdkF-3uk8A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3voo FATTY ACID
ALPHA-HYDROXYLASE

(Sphingomonas
paucimobilis) 		PF00067
(p450) 		3 LEU A  31
PHE A  36
ARG A  22
 None
 0.74A 1xdkF-3vooA:
undetectable		 1xdkF-3vooA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zrh UBIQUITIN
THIOESTERASE ZRANB1

(Homo sapiens) 		PF02338
(OTU) 		3 LEU A 579
PHE A 586
ARG A 557
 None
 0.85A 1xdkF-3zrhA:
undetectable		 1xdkF-3zrhA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2v RETINOIC ACID
INDUCIBLE PROTEIN I

(Anas
platyrhynchos) 		PF11648
(RIG-I_C-RD) 		3 LEU A 810
PHE A 895
ARG A 867
 None
 0.59A 1xdkF-4a2vA:
undetectable		 1xdkF-4a2vA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4apl APICAL MEMBRANE
ANTIGEN 1

(Neospora
caninum) 		PF02430
(AMA-1) 		3 LEU A 223
PHE A 153
ARG A 105
 None
 0.80A 1xdkF-4aplA:
undetectable		 1xdkF-4aplA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4are COLLAGENASE G

(Hathewaya
histolytica) 		PF01752
(Peptidase_M9)
PF08453
(Peptidase_M9_N) 		3 LEU A 617
PHE A 625
ARG A 573
 None
 0.74A 1xdkF-4areA:
undetectable		 1xdkF-4areA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxs VENOM PROTHROMBIN
ACTIVATOR
PSEUTARIN-C
NON-CATALYTIC
SUBUNIT

(Pseudonaja
textilis) 		PF00754
(F5_F8_type_C)
PF07732
(Cu-oxidase_3) 		3 LEU V 614
PHE V 604
ARG V 649
 None
 0.83A 1xdkF-4bxsV:
undetectable		 1xdkF-4bxsV:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN

(Pyrococcus sp.
ST04) 		no annotation 3 LEU A 396
PHE A 395
ARG A 405
 None
 0.83A 1xdkF-4cmrA:
undetectable		 1xdkF-4cmrA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d0k PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN

(Chaetomium
thermophilum) 		no annotation 3 LEU B 542
PHE B 488
ARG B 453
 None
 0.80A 1xdkF-4d0kB:
undetectable		 1xdkF-4d0kB:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dwn BCL10-INTERACTING
CARD PROTEIN

(Homo sapiens) 		no annotation 3 LEU A  10
PHE A  80
ARG A  94
 None
None
SO4  A 102 (-2.5A)
 0.84A 1xdkF-4dwnA:
undetectable		 1xdkF-4dwnA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4epp POLY(ADP-RIBOSE)
GLYCOHYDROLASE

(Tetrahymena
thermophila) 		PF05028
(PARG_cat) 		3 LEU A 266
PHE A 259
ARG A 195
 None
 0.71A 1xdkF-4eppA:
undetectable		 1xdkF-4eppA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hss PUTATIVE FIMBRIAL
SUBUNIT

(Corynebacterium
diphtheriae) 		no annotation 3 LEU A 282
PHE A 284
ARG A 300
 None
 0.82A 1xdkF-4hssA:
undetectable		 1xdkF-4hssA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i2w PROTEIN UNC-45

(Caenorhabditis
elegans) 		PF11701
(UNC45-central) 		3 LEU A 322
PHE A 337
ARG A 311
 None
 0.69A 1xdkF-4i2wA:
undetectable		 1xdkF-4i2wA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8v CYTOCHROME P450 1A1

(Homo sapiens) 		PF00067
(p450) 		3 LEU A 177
PHE A 184
ARG A 477
 None
 0.76A 1xdkF-4i8vA:
undetectable		 1xdkF-4i8vA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jpk GERMLINE-TARGETING
HIV-1 GP120
ENGINEERED OUTER
DOMAIN, EOD-GT6

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		3 LEU A  24
PHE A  38
ARG A  81
 None
 0.66A 1xdkF-4jpkA:
undetectable		 1xdkF-4jpkA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kk7 ESX-1 SECRETION
SYSTEM PROTEIN ECCB1

(Mycobacterium
tuberculosis) 		PF05108
(T7SS_ESX1_EccB) 		3 LEU A 262
PHE A 268
ARG A 322
 None
 0.83A 1xdkF-4kk7A:
undetectable		 1xdkF-4kk7A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kny KDP OPERON
TRANSCRIPTIONAL
REGULATORY PROTEIN
KDPE

(Escherichia
coli) 		PF00072
(Response_reg)
PF00486
(Trans_reg_C) 		3 LEU A  51
PHE A  63
ARG A  44
 None
 0.81A 1xdkF-4knyA:
undetectable		 1xdkF-4knyA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m2g L-ARGININE
BETA-HYDROXYLASE

(Streptomyces
lavendulae) 		PF02668
(TauD) 		3 LEU A  60
PHE A  59
ARG A  68
 None
 0.85A 1xdkF-4m2gA:
undetectable		 1xdkF-4m2gA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mbo SERINE-RICH REPEAT
ADHESION
GLYCOPROTEIN (SRR1)

(Streptococcus
agalactiae) 		PF10425
(SdrG_C_C) 		3 LEU A 542
PHE A 562
ARG A 485
 None
 0.79A 1xdkF-4mboA:
undetectable		 1xdkF-4mboA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n9x PUTATIVE
MONOOXYGENASE

(Pectobacterium
atrosepticum) 		PF01494
(FAD_binding_3) 		3 LEU A 257
PHE A 214
ARG A 247
 None
 0.83A 1xdkF-4n9xA:
undetectable		 1xdkF-4n9xA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nmn REPLICATIVE DNA
HELICASE

(Aquifex
aeolicus) 		PF00772
(DnaB)
PF03796
(DnaB_C) 		3 LEU A 426
PHE A 186
ARG A 246
 None
None
ADP  A1001 (-2.6A)
 0.75A 1xdkF-4nmnA:
undetectable		 1xdkF-4nmnA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oy7 PUTATIVE SECRETED
CELLULOSE BINDING
PROTEIN

(Streptomyces
coelicolor) 		PF03067
(LPMO_10) 		3 LEU A 168
PHE A 207
ARG A  92
 None
 0.81A 1xdkF-4oy7A:
undetectable		 1xdkF-4oy7A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r4z PNGF-II

(Elizabethkingia
meningoseptica) 		PF09112
(N-glycanase_N)
PF09113
(N-glycanase_C) 		3 LEU A 483
PHE A 437
ARG A 247
 None
 0.80A 1xdkF-4r4zA:
undetectable		 1xdkF-4r4zA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		3 LEU A  70
PHE A 160
ARG A 134
 None
 0.83A 1xdkF-4rewA:
undetectable		 1xdkF-4rewA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4um8 INTEGRIN ALPHA-V

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		3 LEU A 538
PHE A 513
ARG A 588
 None
 0.78A 1xdkF-4um8A:
undetectable		 1xdkF-4um8A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ys8 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE

(Burkholderia
thailandensis) 		PF01128
(IspD) 		3 LEU A  39
PHE A  67
ARG A  27
 None
 0.86A 1xdkF-4ys8A:
undetectable		 1xdkF-4ys8A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3f DYNAMIN 3

(Homo sapiens) 		PF00169
(PH)
PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED) 		3 LEU A 617
PHE A 372
ARG A 569
 None
 0.63A 1xdkF-5a3fA:
undetectable		 1xdkF-5a3fA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a53 RIBOSOME BIOGENESIS
PROTEIN RPF2

(Saccharomyces
cerevisiae) 		PF04427
(Brix) 		3 LEU C 160
PHE C 102
ARG C 202
 None
 0.85A 1xdkF-5a53C:
undetectable		 1xdkF-5a53C:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cy1 TRANSPOSON TN3
RESOLVASE

(Escherichia
coli) 		PF00239
(Resolvase)
PF02796
(HTH_7) 		3 LEU A  66
PHE A  92
ARG A  45
 None
 0.71A 1xdkF-5cy1A:
undetectable		 1xdkF-5cy1A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5euf PROTEASE

(Helicobacter
pylori) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		3 LEU A 133
PHE A  96
ARG A 117
 None
 0.85A 1xdkF-5eufA:
undetectable		 1xdkF-5eufA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 LEU B 704
PHE B 724
ARG B 700
 None
 0.85A 1xdkF-5fq6B:
undetectable		 1xdkF-5fq6B:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fyg CYTOCHROME P450

(Marinobacter
hydrocarbonoclasticus) 		PF00067
(p450) 		3 LEU A 294
PHE A 301
ARG A 270
 None
 0.45A 1xdkF-5fygA:
undetectable		 1xdkF-5fygA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h2r PHOSPHODIESTERASE

(Trypanosoma
brucei) 		no annotation 3 LEU A 625
PHE A 671
ARG A 634
 None
 0.81A 1xdkF-5h2rA:
undetectable		 1xdkF-5h2rA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hos CELLULASE

(Xanthomonas
citri) 		PF00150
(Cellulase) 		3 LEU A 248
PHE A 251
ARG A 318
 None
 0.86A 1xdkF-5hosA:
undetectable		 1xdkF-5hosA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6i ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		3 LEU A1988
PHE A1980
ARG A1885
 None
 0.84A 1xdkF-5i6iA:
undetectable		 1xdkF-5i6iA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA

(Homo sapiens) 		no annotation 3 LEU B 606
PHE B 490
ARG B 601
 None
None
SO4  B 909 (-3.8A)
 0.81A 1xdkF-5iz5B:
undetectable		 1xdkF-5iz5B:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1s TORSIN-1A-INTERACTIN
G PROTEIN 2

(Homo sapiens) 		PF05609
(LAP1C) 		3 LEU B 453
PHE B 280
ARG B 449
 None
 0.70A 1xdkF-5j1sB:
undetectable		 1xdkF-5j1sB:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jze RNA-DEPENDENT RNA
POLYMERASE

(Thiafora
orthonairovirus) 		PF02338
(OTU) 		3 LEU A 158
PHE A  32
ARG A 140
 None
 0.83A 1xdkF-5jzeA:
undetectable		 1xdkF-5jzeA:
17.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5k13 RETINOIC ACID
RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		3 LEU A 231
PHE A 286
ARG A 394
 6Q7  A 501 ( 4.3A)
6Q7  A 501 (-4.7A)
None
 0.40A 1xdkF-5k13A:
35.3		 1xdkF-5k13A:
78.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ljm SPERMATOGENESIS-ASSO
CIATED PROTEIN 2

(Homo sapiens) 		no annotation 3 LEU A  52
PHE A  11
ARG A  43
 None
 0.73A 1xdkF-5ljmA:
undetectable		 1xdkF-5ljmA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5omc REPLICATION FACTOR A
PROTEIN 1

(Saccharomyces
cerevisiae) 		no annotation 3 LEU A 120
PHE A  11
ARG A  76
 None
 0.73A 1xdkF-5omcA:
undetectable		 1xdkF-5omcA:
16.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uan RETINOIC ACID
RECEPTOR BETA

(Homo sapiens) 		no annotation 3 LEU B 224
PHE B 279
ARG B 387
 REA  B 503 ( 4.0A)
REA  B 503 (-4.4A)
None
 0.50A 1xdkF-5uanB:
38.3		 1xdkF-5uanB:
98.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ver KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 3

(Mus musculus) 		no annotation 3 LEU A 357
PHE A 447
ARG A 430
 None
None
EPE  A 702 (-3.1A)
 0.70A 1xdkF-5verA:
undetectable		 1xdkF-5verA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vnc GLYCOGEN [STARCH]
SYNTHASE ISOFORM 2

(Saccharomyces
cerevisiae) 		no annotation 3 LEU A 176
PHE A 190
ARG A 230
 None
 0.50A 1xdkF-5vncA:
undetectable		 1xdkF-5vncA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zk4 DISA PROTEIN

(Sorangium
cellulosum) 		no annotation 3 LEU C  49
PHE C  39
ARG C  84
 None
 0.78A 1xdkF-5zk4C:
undetectable		 1xdkF-5zk4C:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6am0 KLLA0F23980P

(Kluyveromyces
lactis) 		no annotation 3 LEU A 114
PHE A 110
ARG A 230
 None
 0.63A 1xdkF-6am0A:
undetectable		 1xdkF-6am0A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao8 ARGININE--TRNA
LIGASE

(Neisseria
gonorrhoeae) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		3 LEU A 173
PHE A 230
ARG A 193
 None
 0.85A 1xdkF-6ao8A:
undetectable		 1xdkF-6ao8A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b12 TNI2

(Pseudomonas
protegens) 		no annotation 3 LEU B  55
PHE B 111
ARG B  92
 None
 0.72A 1xdkF-6b12B:
undetectable		 1xdkF-6b12B:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1

(Homo sapiens) 		no annotation 3 LEU A 263
PHE A 359
ARG A 324
 None
 0.81A 1xdkF-6bfnA:
undetectable		 1xdkF-6bfnA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE

(Rhodothermus
marinus) 		no annotation 3 LEU B 357
PHE B 255
ARG B 285
 None
 0.69A 1xdkF-6f0kB:
undetectable		 1xdkF-6f0kB:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fuy VINCULIN

(Homo sapiens) 		no annotation 3 LEU A 818
PHE A 817
ARG A 759
 None
 0.83A 1xdkF-6fuyA:
undetectable		 1xdkF-6fuyA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fx0 RETINOIC ACID
RECEPTOR GAMMA

(Homo sapiens) 		no annotation 3 LEU A 233
PHE A 288
ARG A 396
 E9T  A 501 ( 4.3A)
E9T  A 501 (-4.7A)
None
 0.34A 1xdkF-6fx0A:
37.2		 1xdkF-6fx0A:
15.51