SIMILAR PATTERNS OF AMINO ACIDS FOR 1XDK_E_9CRE1500_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1air | PECTATE LYASE C (Dickeyachrysanthemi) |
PF00544(Pec_lyase_C) | 5 | ILE A 33ALA A 36ALA A 35ALA A 49VAL A 82 | None | 0.99A | 1xdkE-1airA:undetectable | 1xdkE-1airA:19.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bsg | BETA LACTAMASE (Streptomycesalbus) |
PF13354(Beta-lactamase2) | 5 | ALA A 280PHE A 221ALA A 223VAL A 57LEU A 44 | None | 1.04A | 1xdkE-1bsgA:undetectable | 1xdkE-1bsgA:22.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1csj | HEPATITIS C VIRUSRNA POLYMERASE(NS5B) (Hepacivirus C) |
PF00998(RdRP_3) | 5 | ALA A 249ALA A 174LEU A 245ALA A 246LEU A 285 | None | 0.95A | 1xdkE-1csjA:undetectable | 1xdkE-1csjA:17.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dqu | ISOCITRATE LYASE (Aspergillusnidulans) |
PF00463(ICL) | 5 | ILE A 166ALA A 192ALA A 191LEU A 59ALA A 56 | None | 0.96A | 1xdkE-1dquA:undetectable | 1xdkE-1dquA:20.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e19 | CARBAMATE KINASE (Pyrococcusfuriosus) |
PF00696(AA_kinase) | 6 | ILE A 37ALA A 34LEU A 97ALA A 96VAL A 5LEU A 234 | None | 0.90A | 1xdkE-1e19A:undetectable | 1xdkE-1e19A:22.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fc4 | 2-AMINO-3-KETOBUTYRATE CONENZYME ALIGASE (Escherichiacoli) |
PF00155(Aminotran_1_2) | 5 | ILE A 238ALA A 255ALA A 256LEU A 100ALA A 97 | None | 0.96A | 1xdkE-1fc4A:undetectable | 1xdkE-1fc4A:21.85 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hg4 | ULTRASPIRACLE (Drosophilamelanogaster) |
PF00104(Hormone_recep) | 5 | TRP A 318LEU A 366VAL A 382CYH A 472LEU A 476 | NoneLPP A 1 ( 4.4A)LPP A 1 (-4.8A)LPP A 1 ( 4.2A)LPP A 1 (-4.2A) | 0.71A | 1xdkE-1hg4A:24.7 | 1xdkE-1hg4A:43.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n60 | CARBON MONOXIDEDEHYDROGENASE SMALLCHAIN (Oligotrophacarboxidovorans) |
PF00111(Fer2)PF01799(Fer2_2) | 5 | ILE A 149ALA A 152ALA A 153LEU A 90ALA A 89 | None | 0.92A | 1xdkE-1n60A:undetectable | 1xdkE-1n60A:19.26 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1pcg | ESTROGEN RECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 5 | ALA A 350TRP A 383ARG A 394VAL A 418LEU A 525 | EST A 1 ( 3.7A)NoneEST A 1 (-3.7A)NoneEST A 1 (-3.6A) | 1.01A | 1xdkE-1pcgA:25.8 | 1xdkE-1pcgA:32.94 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1r20 | ULTRASPIRACLEPROTEIN (Heliothisvirescens) |
PF00104(Hormone_recep) | 5 | TRP A 286ARG A 297LEU A 325VAL A 341LEU A 435 | NoneNoneNoneEPH A4000 (-4.9A)EPH A4000 ( 4.6A) | 0.72A | 1xdkE-1r20A:24.4 | 1xdkE-1r20A:45.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1uhl | RETINOIC ACIDRECEPTOR RXR-BETA (Homo sapiens) |
PF00104(Hormone_recep) | 12 | ILE A 339ALA A 342ALA A 343GLN A 346TRP A 376PHE A 384ARG A 387LEU A 397ALA A 398VAL A 413CYH A 503LEU A 507 | MEI A1001 (-3.8A)MEI A1001 (-3.1A)MEI A1001 (-3.3A)NoneNoneMEI A1001 (-4.5A)MEI A1001 (-3.6A)MEI A1001 ( 4.4A)MEI A1001 (-3.4A)MEI A1001 (-4.1A)MEI A1001 (-4.0A)MEI A1001 (-4.6A) | 0.54A | 1xdkE-1uhlA:35.2 | 1xdkE-1uhlA:87.76 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1xiu | RXR-LIKE PROTEIN (Biomphalariaglabrata) |
PF00104(Hormone_recep) | 12 | ILE A 242ALA A 245ALA A 246GLN A 249TRP A 279PHE A 287ARG A 290LEU A 300ALA A 301VAL A 316CYH A 406LEU A 410 | 9CR A 201 ( 4.4A)9CR A 201 (-3.6A)9CR A 201 (-3.6A)9CR A 201 (-4.1A)None9CR A 201 (-4.7A)9CR A 201 (-2.8A)9CR A 201 (-4.4A)9CR A 201 (-3.4A)9CR A 201 (-4.2A)9CR A 201 (-3.6A)9CR A 201 ( 4.8A) | 0.45A | 1xdkE-1xiuA:31.6 | 1xdkE-1xiuA:81.51 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1xls | RETINOIC ACIDRECEPTOR RXR-ALPHA (Homo sapiens) |
PF00104(Hormone_recep) | 12 | ILE A 268ALA A 271ALA A 272GLN A 275TRP A 305PHE A 313ARG A 316LEU A 326ALA A 327VAL A 342CYH A 432LEU A 436 | 9CR A 801 (-3.9A)9CR A 801 (-3.6A)9CR A 801 (-3.5A)9CR A 801 (-4.7A)None9CR A 801 (-4.3A)9CR A 801 (-2.6A)9CR A 801 (-4.1A)9CR A 801 (-3.3A)9CR A 801 ( 4.3A)9CR A 801 ( 3.7A)9CR A 801 (-4.7A) | 0.40A | 1xdkE-1xlsA:34.9 | 1xdkE-1xlsA:99.57 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1z5x | ULTRASPIRACLEPROTEIN (USP) AHOMOLOGUE OF RXR (Bemisia tabaci) |
PF00104(Hormone_recep) | 5 | ILE U 303ALA U 306ALA U 307LEU U 365ALA U 362 | None | 0.91A | 1xdkE-1z5xU:22.1 | 1xdkE-1z5xU:68.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z69 | COENZYMEF420-DEPENDENTN(5),N(10)-METHYLENETETRAHYDROMETHANOPTERIN REDUCTASE (Methanosarcinabarkeri) |
PF00296(Bac_luciferase) | 5 | ILE A 258ALA A 257PHE A 263LEU A 266ALA A 265 | None | 1.04A | 1xdkE-1z69A:undetectable | 1xdkE-1z69A:21.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zk7 | MERCURIC REDUCTASE (Pseudomonasaeruginosa) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 6 | ALA A 452ALA A 451GLN A 453LEU A 434ALA A 435VAL A 356 | NoneNoneGOL A3003 ( 3.8A)NoneNoneNone | 1.41A | 1xdkE-1zk7A:undetectable | 1xdkE-1zk7A:19.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2abj | BRANCHED-CHAIN-AMINO-ACIDAMINOTRANSFERASE,CYTOSOLIC (Homo sapiens) |
PF01063(Aminotran_4) | 5 | ILE A 292ALA A 296GLN A 298VAL A 335LEU A 359 | None | 0.96A | 1xdkE-2abjA:undetectable | 1xdkE-2abjA:22.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ayx | SENSOR KINASEPROTEIN RCSC (Escherichiacoli) |
PF00072(Response_reg)PF09456(RcsC) | 5 | ALA A 787ARG A 767LEU A 718ALA A 786VAL A 746 | None | 1.04A | 1xdkE-2ayxA:undetectable | 1xdkE-2ayxA:21.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cfm | THERMOSTABLE DNALIGASE (Pyrococcusfuriosus) |
PF01068(DNA_ligase_A_M)PF04675(DNA_ligase_A_N)PF04679(DNA_ligase_A_C) | 5 | ALA A 146ALA A 151LEU A 111VAL A 123LEU A 65 | None | 1.02A | 1xdkE-2cfmA:undetectable | 1xdkE-2cfmA:17.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fv2 | RCD1 REQUIRED FORCELLDIFFERENTIATION1HOMOLOG (Homo sapiens) |
PF04078(Rcd1) | 5 | ALA A 85GLN A 82LEU A 130ALA A 129LEU A 51 | None | 0.82A | 1xdkE-2fv2A:undetectable | 1xdkE-2fv2A:24.57 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2gl8 | RETINOIC ACIDRECEPTOR RXR-GAMMA (Homo sapiens) |
PF00104(Hormone_recep) | 7 | TRP A 84PHE A 92ARG A 95LEU A 105ALA A 106VAL A 121CYH A 211 | None | 0.78A | 1xdkE-2gl8A:27.0 | 1xdkE-2gl8A:85.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hsd | 3-ALPHA, 20BETA-HYDROXYSTEROIDDEHYDROGENASE (Streptomycesexfoliatus) |
PF13561(adh_short_C2) | 5 | ILE A 11ALA A 36GLN A 57TRP A 67VAL A 221 | None | 1.05A | 1xdkE-2hsdA:undetectable | 1xdkE-2hsdA:22.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ix5 | ACYL-COENZYME AOXIDASE 4,PEROXISOMAL (Arabidopsisthaliana) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 5 | ALA A 101LEU A 166ALA A 164VAL A 74CYH A 69 | None | 1.01A | 1xdkE-2ix5A:undetectable | 1xdkE-2ix5A:20.97 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2nxx | ULTRASPIRACLE (USP,NR2B4) (Triboliumcastaneum) |
PF00104(Hormone_recep) | 5 | PHE A 259ARG A 262LEU A 272ALA A 273CYH A 378 | None | 0.77A | 1xdkE-2nxxA:24.6 | 1xdkE-2nxxA:62.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p6w | PUTATIVEGLYCOSYLTRANSFERASE(MANNOSYLTRANSFERASE) INVOLVED INGLYCOSYLATING THEPBCV-1 MAJOR CAPSIDPROTEIN (ParameciumbursariaChlorella virus1) |
PF05637(Glyco_transf_34) | 5 | ILE A 61ALA A 64ALA A 65LEU A 9VAL A 136 | None | 1.02A | 1xdkE-2p6wA:undetectable | 1xdkE-2p6wA:23.75 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2q60 | RETINOID X RECEPTOR (Polyandrocarpamisakiensis) |
PF00104(Hormone_recep) | 6 | TRP A 180PHE A 188ARG A 191ALA A 202VAL A 217CYH A 307 | None | 0.51A | 1xdkE-2q60A:26.9 | 1xdkE-2q60A:72.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q8w | POKEWEED ANTIVIRALPROTEIN (Phytolaccaacinosa) |
PF00161(RIP) | 5 | ILE A 214ALA A 217ARG A 240LEU A 222ALA A 221 | None | 0.98A | 1xdkE-2q8wA:undetectable | 1xdkE-2q8wA:22.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qpm | CYTOKININDEHYDROGENASE 1 (Zea mays) |
PF01565(FAD_binding_4)PF09265(Cytokin-bind) | 5 | ILE A 315ALA A 313LEU A 301ALA A 302VAL A 360 | None | 1.04A | 1xdkE-2qpmA:undetectable | 1xdkE-2qpmA:19.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vml | PHYCOCYANIN ALPHACHAINPHYCOCYANIN BETACHAIN (Gloeobacterviolaceus) |
PF00502(Phycobilisome) | 5 | ALA A 40ALA A 41ALA A 150VAL B 31LEU B 24 | None | 0.96A | 1xdkE-2vmlA:undetectable | 1xdkE-2vmlA:20.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vsx | EUKARYOTICINITIATION FACTOR 4FSUBUNIT P150 (Saccharomycescerevisiae) |
PF02854(MIF4G) | 5 | ILE E 652ALA E 656LEU E 614VAL E 673LEU E 753 | None | 1.03A | 1xdkE-2vsxE:undetectable | 1xdkE-2vsxE:27.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xax | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1SUBUNIT ALPHA (Escherichiacoli) |
PF00317(Ribonuc_red_lgN)PF02867(Ribonuc_red_lgC)PF03477(ATP-cone) | 5 | ILE A 62ALA A 66ALA A 65LEU A 84ALA A 81 | None | 1.01A | 1xdkE-2xaxA:undetectable | 1xdkE-2xaxA:17.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xgo | XCOGT (Xanthomonascampestris) |
PF13432(TPR_16)PF13844(Glyco_transf_41) | 5 | ALA A 549PHE A 228LEU A 231ALA A 230LEU A 328 | None | 1.03A | 1xdkE-2xgoA:undetectable | 1xdkE-2xgoA:18.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3afg | SUBTILISIN-LIKESERINE PROTEASE (Thermococcuskodakarensis) |
PF00082(Peptidase_S8)PF04151(PPC) | 5 | ILE A 368ALA A 415ALA A 416LEU A 388ALA A 387 | None | 0.98A | 1xdkE-3afgA:undetectable | 1xdkE-3afgA:17.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3am6 | RHODOPSIN-2 (Acetabulariaacetabulum) |
PF01036(Bac_rhodopsin) | 5 | ILE A 44ALA A 47VAL A 95CYH A 218LEU A 219 | NoneNoneNoneNoneCLR A 401 ( 4.6A) | 1.01A | 1xdkE-3am6A:undetectable | 1xdkE-3am6A:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ce6 | ADENOSYLHOMOCYSTEINASE (Mycobacteriumtuberculosis) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | ALA A 104ALA A 102PHE A 31LEU A 28ALA A 29 | None | 1.04A | 1xdkE-3ce6A:undetectable | 1xdkE-3ce6A:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ci0 | PSEUDOPILIN GSPK (Escherichiacoli) |
PF03934(T2SSK) | 5 | ILE K 218ALA K 221LEU K 119ALA K 118LEU K 271 | None | 0.98A | 1xdkE-3ci0K:undetectable | 1xdkE-3ci0K:23.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d0q | PROTEIN CALG3 (Micromonosporaechinospora) |
PF06722(DUF1205) | 5 | ILE A 233ALA A 236ALA A 237ALA A 334LEU A 246 | None | 0.94A | 1xdkE-3d0qA:undetectable | 1xdkE-3d0qA:23.48 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3dzu | RETINOIC ACIDRECEPTOR RXR-ALPHA (Homo sapiens) |
PF00104(Hormone_recep)PF00105(zf-C4) | 12 | ILE A 268ALA A 271ALA A 272GLN A 275TRP A 305PHE A 313ARG A 316LEU A 326ALA A 327VAL A 342CYH A 432LEU A 436 | 9CR A7223 (-3.9A)9CR A7223 (-3.5A)9CR A7223 (-4.2A)9CR A7223 (-4.6A)None9CR A7223 (-4.5A)9CR A7223 (-3.7A)9CR A7223 (-3.8A)9CR A7223 ( 4.7A)9CR A7223 ( 4.5A)9CR A7223 (-3.8A)9CR A7223 ( 4.7A) | 0.67A | 1xdkE-3dzuA:33.7 | 1xdkE-3dzuA:99.16 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3eyb | NUCLEAR HORMONERECEPTOR RXR (Branchiostomafloridae) |
PF00104(Hormone_recep) | 5 | PHE A 342LEU A 355ALA A 356VAL A 371CYH A 461 | None | 0.98A | 1xdkE-3eybA:28.1 | 1xdkE-3eybA:84.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3goc | ENDONUCLEASE V (Streptomycesavermitilis) |
PF04493(Endonuclease_5) | 5 | ALA A 74ALA A 59LEU A 104ALA A 103CYH A 113 | None | 1.04A | 1xdkE-3gocA:undetectable | 1xdkE-3gocA:22.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h5k | RIBOSOME-INACTIVATING PROTEINPD-L1/PD-L2 (Phytolaccadioica) |
PF00161(RIP) | 5 | ILE A 214ALA A 217ARG A 240LEU A 222ALA A 221 | None | 0.95A | 1xdkE-3h5kA:undetectable | 1xdkE-3h5kA:19.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hve | GIGAXONIN (Homo sapiens) |
PF00651(BTB)PF07707(BACK) | 5 | ILE A 47ALA A 50ALA A 51LEU B 20ALA B 19 | None | 0.64A | 1xdkE-3hveA:undetectable | 1xdkE-3hveA:21.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hve | GIGAXONIN (Homo sapiens) |
PF00651(BTB)PF07707(BACK) | 5 | ILE A 47ALA A 50LEU B 20ALA B 19LEU A 87 | None | 0.69A | 1xdkE-3hveA:undetectable | 1xdkE-3hveA:21.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hve | GIGAXONIN (Homo sapiens) |
PF00651(BTB)PF07707(BACK) | 5 | ILE B 47ALA B 50ALA B 51LEU A 20ALA A 19 | None | 0.72A | 1xdkE-3hveB:undetectable | 1xdkE-3hveB:18.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hve | GIGAXONIN (Homo sapiens) |
PF00651(BTB)PF07707(BACK) | 5 | ILE B 47ALA B 50LEU A 20ALA A 19LEU B 87 | None | 0.91A | 1xdkE-3hveB:undetectable | 1xdkE-3hveB:18.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ic5 | PUTATIVESACCHAROPINEDEHYDROGENASE (Ruegeriapomeroyi) |
PF03435(Sacchrp_dh_NADP) | 5 | ILE A 82ALA A 85ALA A 86LEU A 60ALA A 61 | None | 0.80A | 1xdkE-3ic5A:undetectable | 1xdkE-3ic5A:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ipc | ABC TRANSPORTER,SUBSTRATE BINDINGPROTEIN (AMINO ACID) (Agrobacteriumfabrum) |
PF13458(Peripla_BP_6) | 5 | ILE A 286ALA A 289ALA A 290LEU A 305ALA A 304 | None | 0.69A | 1xdkE-3ipcA:undetectable | 1xdkE-3ipcA:23.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k11 | PUTATIVE GLYCOSYLHYDROLASE (Bacteroidesthetaiotaomicron) |
PF07470(Glyco_hydro_88) | 5 | ILE A 228ALA A 232ALA A 230GLN A 233LEU A 164 | None | 0.96A | 1xdkE-3k11A:undetectable | 1xdkE-3k11A:19.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ktc | XYLOSE ISOMERASE (Pectobacteriumatrosepticum) |
PF01261(AP_endonuc_2) | 5 | ILE A 292ALA A 295LEU A 324ALA A 323VAL A 230 | None | 0.94A | 1xdkE-3ktcA:undetectable | 1xdkE-3ktcA:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l6a | EUKARYOTICTRANSLATIONINITIATION FACTOR 4GAMMA 2 (Homo sapiens) |
PF02020(W2)PF02847(MA3) | 5 | ALA A 111GLN A 143LEU A 144VAL A 162LEU A 128 | NoneNoneNoneMES A 361 (-3.6A)None | 1.03A | 1xdkE-3l6aA:undetectable | 1xdkE-3l6aA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l8k | DIHYDROLIPOYLDEHYDROGENASE (Sulfolobussolfataricus) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | ILE A 176ALA A 266ALA A 265ALA A 143VAL A 245 | None | 1.05A | 1xdkE-3l8kA:undetectable | 1xdkE-3l8kA:19.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lwg | HP0420 HOMOLOGUE (Helicobacterfelis) |
no annotation | 5 | ILE A 56ALA A 59ALA A 60LEU A 38ALA A 24 | None | 0.98A | 1xdkE-3lwgA:undetectable | 1xdkE-3lwgA:20.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o0m | HIT FAMILY PROTEIN (Mycolicibacteriumsmegmatis) |
PF01230(HIT) | 5 | ILE A 67ALA A 70ALA A 71LEU A 136ALA A 135 | None | 0.66A | 1xdkE-3o0mA:undetectable | 1xdkE-3o0mA:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o10 | SACSIN (Homo sapiens) |
PF05168(HEPN) | 5 | ALA A4487ALA A4488LEU A4451ALA A4447LEU A4519 | None | 0.92A | 1xdkE-3o10A:undetectable | 1xdkE-3o10A:18.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oks | 4-AMINOBUTYRATETRANSAMINASE (Mycolicibacteriumsmegmatis) |
PF00202(Aminotran_3) | 5 | ILE A 327ALA A 331ALA A 330LEU A 298ALA A 295 | None | 0.93A | 1xdkE-3oksA:undetectable | 1xdkE-3oksA:19.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rko | NADH-QUINONEOXIDOREDUCTASESUBUNIT N (Escherichiacoli) |
no annotation | 5 | ILE N 250ALA N 249LEU N 119ALA N 120LEU N 306 | None | 0.91A | 1xdkE-3rkoN:undetectable | 1xdkE-3rkoN:19.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rmj | 2-ISOPROPYLMALATESYNTHASE (Neisseriameningitidis) |
PF00682(HMGL-like) | 6 | ILE A 156ALA A 159TRP A 201PHE A 140ALA A 163LEU A 189 | None | 1.32A | 1xdkE-3rmjA:undetectable | 1xdkE-3rmjA:22.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ttf | TRANSCRIPTIONALREGULATORY PROTEIN (Escherichiacoli) |
PF01300(Sua5_yciO_yrdC)PF07503(zf-HYPF) | 5 | ALA A 602ALA A 600LEU A 622ALA A 618VAL A 636 | None | 1.03A | 1xdkE-3ttfA:undetectable | 1xdkE-3ttfA:18.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ttf | TRANSCRIPTIONALREGULATORY PROTEIN (Escherichiacoli) |
PF01300(Sua5_yciO_yrdC)PF07503(zf-HYPF) | 5 | ALA A 602LEU A 622ALA A 618VAL A 636LEU A 655 | None | 1.01A | 1xdkE-3ttfA:undetectable | 1xdkE-3ttfA:18.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uc2 | HYPOTHETICAL PROTEINWITHIMMUNOGLOBULIN-LIKEFOLD (Pseudomonasaeruginosa) |
PF14467(DUF4426) | 5 | ILE A 59ALA A 103GLN A 104PHE A 105LEU A 88 | None | 1.03A | 1xdkE-3uc2A:undetectable | 1xdkE-3uc2A:20.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3upn | PENICILLIN-BINDINGPROTEIN A (Mycobacteriumtuberculosis) |
PF00905(Transpeptidase) | 5 | ALA A 231ALA A 232LEU A 298ALA A 297LEU A 243 | None | 1.05A | 1xdkE-3upnA:undetectable | 1xdkE-3upnA:18.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3upn | PENICILLIN-BINDINGPROTEIN A (Mycobacteriumtuberculosis) |
PF00905(Transpeptidase) | 5 | ALA A 231ALA A 232LEU A 298ALA A 297LEU A 274 | None | 0.96A | 1xdkE-3upnA:undetectable | 1xdkE-3upnA:18.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ut2 | CATALASE-PEROXIDASE2 (Magnaportheoryzae) |
PF00141(peroxidase) | 5 | ILE A 505ALA A 593ALA A 592LEU A 516ALA A 517 | None | 1.05A | 1xdkE-3ut2A:undetectable | 1xdkE-3ut2A:14.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w3s | TYPE-2 SERINE--TRNALIGASE (Methanopyruskandleri) |
PF00587(tRNA-synt_2b) | 5 | ALA A 76ALA A 77LEU A 38VAL A 26LEU A 11 | None | 1.05A | 1xdkE-3w3sA:undetectable | 1xdkE-3w3sA:19.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wc3 | ENDO-1,4-BETA-GLUCANASE (Eisenia fetida) |
PF00759(Glyco_hydro_9) | 5 | ALA A 178ALA A 177PHE A 87ALA A 86LEU A 280 | None | 1.06A | 1xdkE-3wc3A:undetectable | 1xdkE-3wc3A:18.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wuy | NITRILASE (Synechocystissp. PCC 6803) |
PF00795(CN_hydrolase) | 5 | ILE A 93ALA A 96ALA A 97LEU A 35VAL A 108 | None | 1.03A | 1xdkE-3wuyA:undetectable | 1xdkE-3wuyA:24.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wxw | ADIPONECTIN RECEPTORPROTEIN 2 (Homo sapiens) |
PF03006(HlyIII) | 5 | ILE A 322ALA A 325ALA A 326LEU A 283ALA A 279 | None | 0.67A | 1xdkE-3wxwA:undetectable | 1xdkE-3wxwA:23.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zil | AAR187CP (Eremotheciumgossypii) |
PF16997(Wap1) | 6 | ILE A 359ALA A 356TRP A 338LEU A 397ALA A 393LEU A 335 | None | 1.41A | 1xdkE-3zilA:undetectable | 1xdkE-3zilA:20.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zrg | PEXRD2 FAMILYSECRETED RXLREFFECTOR PEPTIDE,PUTATIVE (Phytophthorainfestans) |
no annotation | 6 | ILE A 86ALA A 89ALA A 90LEU A 99ALA A 95VAL A 73 | NoneNoneNone BR A1122 ( 4.5A)NoneNone | 1.48A | 1xdkE-3zrgA:undetectable | 1xdkE-3zrgA:15.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b8b | GENERAL NEGATIVEREGULATOR OFTRANSCRIPTIONSUBUNIT 1 (Saccharomycescerevisiae) |
PF16417(CNOT1_TTP_bind)PF16418(CNOT1_HEAT)PF16419(CNOT1_HEAT_N) | 6 | ILE A 741ALA A 744ALA A 745LEU A 714ALA A 715VAL A 728 | None | 1.14A | 1xdkE-4b8bA:undetectable | 1xdkE-4b8bA:17.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i59 | CYCLOHEXYLAMINEOXIDASE (Microbacteriumoxydans) |
PF01593(Amino_oxidase) | 5 | ALA A 471ALA A 470LEU A 50ALA A 49VAL A 273 | None | 0.93A | 1xdkE-4i59A:undetectable | 1xdkE-4i59A:18.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ia4 | AQUAPORIN (Spinaciaoleracea) |
PF00230(MIP) | 5 | ALA A 257ALA A 258GLN A 261LEU A 110ALA A 111 | None | 0.83A | 1xdkE-4ia4A:undetectable | 1xdkE-4ia4A:22.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4j5x | RETINOIC ACIDRECEPTOR RXR-ALPHA,NUCLEAR RECEPTORCOACTIVATOR 1 (Homo sapiens) |
no annotation | 12 | ILE D 268ALA D 271ALA D 272GLN D 275TRP D 305PHE D 313ARG D 316LEU D 326ALA D 327VAL D 342CYH D 432LEU D 436 | None | 0.58A | 1xdkE-4j5xD:34.1 | 1xdkE-4j5xD:99.15 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4j5x | RETINOIC ACIDRECEPTOR RXR-ALPHA,NUCLEAR RECEPTORCOACTIVATOR 1 (Homo sapiens) |
no annotation | 6 | ILE D 268ALA D 271GLN D 275PHE D 313VAL D 342CYH D 432 | None | 1.44A | 1xdkE-4j5xD:34.1 | 1xdkE-4j5xD:99.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ks8 | SERINE/THREONINE-PROTEIN KINASE PAK 6 (Homo sapiens) |
PF00069(Pkinase) | 5 | ILE A 503GLN A 660LEU A 631VAL A 493LEU A 667 | None | 1.03A | 1xdkE-4ks8A:undetectable | 1xdkE-4ks8A:23.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lvc | S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE(SAHASE) (Bradyrhizobiumelkanii) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | ALA A 93ALA A 91PHE A 20LEU A 17ALA A 18 | None | 1.06A | 1xdkE-4lvcA:undetectable | 1xdkE-4lvcA:21.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mij | TRAP DICARBOXYLATETRANSPORTER, DCTPSUBUNIT (Polaromonas sp.JS666) |
PF03480(DctP) | 5 | ILE A 261ALA A 265ALA A 264LEU A 146ALA A 147 | None | 1.03A | 1xdkE-4mijA:undetectable | 1xdkE-4mijA:24.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nn1 | TRANSCRIPTIONALREGULATOR (Mycobacteriumtuberculosis) |
PF00440(TetR_N) | 5 | ILE A 12ALA A 15ALA A 16GLN A 19ALA A 35 | None | 0.54A | 1xdkE-4nn1A:undetectable | 1xdkE-4nn1A:26.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o5a | LACI FAMILYTRANSCRIPTIONREGULATOR (Bifidobacteriumanimalis) |
PF13377(Peripla_BP_3) | 5 | ALA A 309ALA A 308LEU A 96ALA A 95LEU A 133 | None | 0.94A | 1xdkE-4o5aA:undetectable | 1xdkE-4o5aA:21.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p47 | TRAP DICARBOXYLATETRANSPORTER, DCTPSUBUNIT (Ochrobactrumanthropi) |
PF03480(DctP) | 5 | ILE A 260ALA A 264ALA A 263LEU A 144ALA A 145 | None | 0.96A | 1xdkE-4p47A:undetectable | 1xdkE-4p47A:22.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rrj | PROBABLETHREONINE--TRNALIGASE 2 (Aeropyrumpernix) |
PF08915(tRNA-Thr_ED) | 5 | ILE A 58ALA A 55ALA A 54LEU A 99ALA A 98 | None | 0.98A | 1xdkE-4rrjA:undetectable | 1xdkE-4rrjA:22.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x9n | L-ALPHA-GLYCEROPHOSPHATE OXIDASE (Mycoplasmapneumoniae) |
PF01266(DAO) | 5 | ALA A 209ALA A 208LEU A 216ALA A 213VAL A 202 | FAD A 401 (-3.6A)NoneNoneNoneNone | 0.91A | 1xdkE-4x9nA:undetectable | 1xdkE-4x9nA:19.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xbo | TRNA(CYTIDINE/URIDINE-2'-O-)-METHYLTRANSFERASE TRMJ (Escherichiacoli) |
PF00588(SpoU_methylase) | 6 | ALA A 53ALA A 22LEU A 49ALA A 50VAL A 40LEU A 9 | None | 1.11A | 1xdkE-4xboA:undetectable | 1xdkE-4xboA:23.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xgj | UNCHARACTERIZEDPROTEIN (Pectobacteriumatrosepticum) |
PF07005(DUF1537)PF17042(DUF1357_C) | 6 | ILE A 211ALA A 214ALA A 215LEU A 183ALA A 184LEU A 230 | None | 1.06A | 1xdkE-4xgjA:undetectable | 1xdkE-4xgjA:19.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xgj | UNCHARACTERIZEDPROTEIN (Pectobacteriumatrosepticum) |
PF07005(DUF1537)PF17042(DUF1357_C) | 5 | ILE A 350ALA A 353LEU A 299VAL A 251LEU A 386 | None | 1.02A | 1xdkE-4xgjA:undetectable | 1xdkE-4xgjA:19.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yk2 | BARTONELLA EFFECTORPROTEIN (BEP)SUBSTRATE OF VIRBT4SS (Bartonellaclarridgeiae) |
no annotation | 5 | ILE A 160ALA A 156PHE A 103LEU A 140ALA A 141 | None | 0.88A | 1xdkE-4yk2A:undetectable | 1xdkE-4yk2A:20.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zoh | PUTATIVEOXIDOREDUCTASEFAD-BINDING SUBUNIT (Sulfurisphaeratokodaii) |
PF00941(FAD_binding_5)PF03450(CO_deh_flav_C) | 5 | ILE B 236ALA B 239ALA B 240LEU B 226ALA B 222 | None | 1.02A | 1xdkE-4zohB:undetectable | 1xdkE-4zohB:23.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gt5 | PECTATE LYASE (Paenibacillussp. 0602) |
no annotation | 5 | ILE A 117ALA A 116ALA A 115PHE A 132LEU A 39 | None | 0.96A | 1xdkE-5gt5A:undetectable | 1xdkE-5gt5A:20.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5iuw | ALDEHYDEDEHYDROGENASE FAMILYPROTEIN (Pseudomonassyringae groupgenomosp. 3) |
no annotation | 5 | ILE A 294ALA A 291ALA A 290LEU A 326ALA A 325 | None | 1.06A | 1xdkE-5iuwA:undetectable | 1xdkE-5iuwA:20.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j5v | IMMUNITY PROTEINCDII (Escherichiacoli) |
no annotation | 5 | ILE C 30ALA C 46GLN C 49PHE C 27LEU C 35 | None | 1.06A | 1xdkE-5j5vC:undetectable | 1xdkE-5j5vC:18.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lnq | 3-KETOACYL-COATHIOLASE-LIKEPROTEIN (Leishmaniamexicana) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 5 | ALA A 142GLN A 75LEU A 137ALA A 136LEU A 66 | None | 1.06A | 1xdkE-5lnqA:undetectable | 1xdkE-5lnqA:19.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n0g | PRECORRIN-8XMETHYLMUTASE (Rhodobactercapsulatus) |
no annotation | 6 | ILE A 73ALA A 71ALA A 130LEU A 67ALA A 66VAL A 80 | None | 1.20A | 1xdkE-5n0gA:undetectable | 1xdkE-5n0gA:18.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oaf | RUVB-LIKE 1 (Homo sapiens) |
no annotation | 5 | ALA A 82GLN A 85PHE A 93LEU A 87VAL A 66 | None | 1.05A | 1xdkE-5oafA:undetectable | 1xdkE-5oafA:18.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ohs | - (-) |
no annotation | 5 | ILE A 257ALA A 260PHE A 541LEU A 538ALA A 539 | None | 0.87A | 1xdkE-5ohsA:undetectable | 1xdkE-5ohsA:undetectable | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5uan | RETINOIC ACIDRECEPTOR RXR-ALPHA (Homo sapiens) |
no annotation | 12 | ILE A 268ALA A 271ALA A 272GLN A 275TRP A 305PHE A 313ARG A 316LEU A 326ALA A 327VAL A 342CYH A 432LEU A 436 | 9CR A 503 (-4.0A)9CR A 503 (-3.5A)9CR A 503 (-3.5A)9CR A 503 (-3.8A)None9CR A 503 (-4.7A)9CR A 503 (-3.0A)9CR A 503 (-4.3A)9CR A 503 (-3.4A)None9CR A 503 (-3.3A)9CR A 503 ( 4.8A) | 0.55A | 1xdkE-5uanA:34.4 | 1xdkE-5uanA:99.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xyi | RIBOSOMAL PROTEINS19E, PUTATIVE (Trichomonasvaginalis) |
PF01090(Ribosomal_S19e) | 5 | ILE T 68ALA T 65ALA T 64LEU T 25ALA T 26 | None | 0.97A | 1xdkE-5xyiT:undetectable | 1xdkE-5xyiT:19.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xyi | RIBOSOMAL PROTEINS19E, PUTATIVE (Trichomonasvaginalis) |
PF01090(Ribosomal_S19e) | 5 | ILE T 68ALA T 65LEU T 25ALA T 26LEU T 111 | None | 0.98A | 1xdkE-5xyiT:undetectable | 1xdkE-5xyiT:19.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c66 | CRISPR-ASSOCIATEDPROTEIN, CSE1 FAMILY (Thermobifidafusca) |
no annotation | 5 | ILE A 71LEU A 273ALA A 268VAL A 182LEU A 44 | None | 0.99A | 1xdkE-6c66A:undetectable | 1xdkE-6c66A:21.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6d95 | - (-) |
no annotation | 5 | ILE A 129ALA A 132ALA A 133LEU A 267ALA A 266 | None | 0.57A | 1xdkE-6d95A:undetectable | 1xdkE-6d95A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6g96 | ACETYLTRANSFERASE (Salmonellaenterica) |
no annotation | 5 | TRP B 142LEU B 169ALA B 168VAL B 64LEU B 95 | ACO B 201 ( 3.9A)NoneNoneNoneACO B 201 (-4.6A) | 1.04A | 1xdkE-6g96B:undetectable | 1xdkE-6g96B:16.26 |