SIMILAR PATTERNS OF AMINO ACIDS FOR 1XDK_B_9CRB600_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dnp DNA PHOTOLYASE

(Escherichia
coli)
PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7)
5 LEU A 272
LEU A 275
ILE A 276
LEU A 158
LEU A 255
None
FAD  A 472 ( 4.7A)
None
None
None
1.26A 1xdkB-1dnpA:
0.0
1xdkB-1dnpA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1k ADRENODOXIN
REDUCTASE


(Bos taurus)
PF07992
(Pyr_redox_2)
5 LEU A 210
ILE A 194
SER A 328
LEU A 223
LEU A 245
None
None
NAP  A 802 (-4.1A)
None
None
0.97A 1xdkB-1e1kA:
undetectable
1xdkB-1e1kA:
21.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1exx RETINOIC ACID
RECEPTOR GAMMA-2


(Homo sapiens)
PF00104
(Hormone_recep)
9 PHE A 230
ALA A 234
CYH A 237
LEU A 268
LEU A 271
ILE A 275
ARG A 278
SER A 289
PHE A 304
961  A 450 (-3.9A)
961  A 450 (-3.1A)
961  A 450 (-3.6A)
961  A 450 ( 4.9A)
961  A 450 (-3.6A)
961  A 450 (-3.5A)
961  A 450 (-3.6A)
961  A 450 (-2.5A)
961  A 450 (-3.6A)
0.54A 1xdkB-1exxA:
37.3
1xdkB-1exxA:
81.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1exx RETINOIC ACID
RECEPTOR GAMMA-2


(Homo sapiens)
PF00104
(Hormone_recep)
5 PHE A 230
ALA A 234
CYH A 237
PHE A 304
LEU A 268
961  A 450 (-3.9A)
961  A 450 (-3.1A)
961  A 450 (-3.6A)
961  A 450 (-3.6A)
961  A 450 ( 4.9A)
1.13A 1xdkB-1exxA:
37.3
1xdkB-1exxA:
81.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1exx RETINOIC ACID
RECEPTOR GAMMA-2


(Homo sapiens)
PF00104
(Hormone_recep)
7 PHE A 230
ALA A 234
ILE A 275
ARG A 278
SER A 289
PHE A 304
LEU A 307
961  A 450 (-3.9A)
961  A 450 (-3.1A)
961  A 450 (-3.5A)
961  A 450 (-3.6A)
961  A 450 (-2.5A)
961  A 450 (-3.6A)
961  A 450 (-4.8A)
0.55A 1xdkB-1exxA:
37.3
1xdkB-1exxA:
81.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1exx RETINOIC ACID
RECEPTOR GAMMA-2


(Homo sapiens)
PF00104
(Hormone_recep)
5 PHE A 230
ALA A 234
PHE A 304
LEU A 307
LEU A 268
961  A 450 (-3.9A)
961  A 450 (-3.1A)
961  A 450 (-3.6A)
961  A 450 (-4.8A)
961  A 450 ( 4.9A)
1.02A 1xdkB-1exxA:
37.3
1xdkB-1exxA:
81.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH


(Escherichia
coli)
PF00588
(SpoU_methylase)
PF08032
(SpoU_sub_bind)
5 ALA A  72
LEU A  39
ILE A   8
SER A  62
LEU A  43
None
0.86A 1xdkB-1gz0A:
undetectable
1xdkB-1gz0A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1seh DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDOHYDROLASE


(Escherichia
coli)
PF00692
(dUTPase)
5 LEU A  97
ILE A  89
ILE A  59
PHE A 122
LEU A  55
UMP  A 777 (-4.7A)
UMP  A 777 (-3.9A)
None
None
None
1.22A 1xdkB-1sehA:
undetectable
1xdkB-1sehA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 41 KDA
SUBUNIT


(Saccharomyces
cerevisiae)
PF00004
(AAA)
PF08542
(Rep_fac_C)
5 PHE D 189
ALA D  45
LEU D  36
LEU D  49
SER D 185
None
1.26A 1xdkB-1sxjD:
undetectable
1xdkB-1sxjD:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t90 PROBABLE
METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE


(Bacillus
subtilis)
PF00171
(Aldedh)
5 PHE A 163
LEU A  86
PHE A  75
LEU A 191
LEU A 184
None
1.11A 1xdkB-1t90A:
undetectable
1xdkB-1t90A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukf AVIRULENCE PROTEIN
AVRPPH3


(Pseudomonas
savastanoi)
PF03543
(Peptidase_C58)
5 LEU A 225
ILE A 244
ILE A 248
SER A 253
LEU A 202
None
0.90A 1xdkB-1ukfA:
0.0
1xdkB-1ukfA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1upr PLECKSTRIN HOMOLOGY
DOMAIN-CONTAINING
FAMILY A MEMBER 4


(Homo sapiens)
PF00169
(PH)
5 ALA A1147
LEU A1084
LEU A1079
LEU A1133
LEU A1101
None
1.16A 1xdkB-1uprA:
0.0
1xdkB-1uprA:
16.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xap RETINOIC ACID
RECEPTOR BETA


(Homo sapiens)
PF00104
(Hormone_recep)
10 PHE A 221
ALA A 225
CYH A 228
LEU A 259
LEU A 262
ILE A 263
ILE A 266
ARG A 269
SER A 280
PHE A 295
TTB  A   1 (-4.7A)
TTB  A   1 (-4.0A)
TTB  A   1 ( 3.8A)
TTB  A   1 ( 4.9A)
TTB  A   1 (-3.9A)
TTB  A   1 ( 4.9A)
TTB  A   1 ( 4.0A)
TTB  A   1 (-3.3A)
TTB  A   1 (-3.1A)
TTB  A   1 ( 4.1A)
0.46A 1xdkB-1xapA:
37.1
1xdkB-1xapA:
92.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8t HYPOTHETICAL PROTEIN
RV0983


(Mycobacterium
tuberculosis)
PF13180
(PDZ_2)
PF13365
(Trypsin_2)
5 ALA A 217
LEU A  38
ILE A  37
ILE A  44
LEU A 105
None
1.24A 1xdkB-1y8tA:
undetectable
1xdkB-1y8tA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9q TRANSCRIPTIONAL
REGULATOR, HTH_3
FAMILY


(Vibrio cholerae)
PF01381
(HTH_3)
5 LEU A  19
LEU A  16
ILE A  12
SER A  49
LEU A  63
None
1.04A 1xdkB-1y9qA:
undetectable
1xdkB-1y9qA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy2 TRANSCRIPTIONAL
REGULATOR NTRC1


(Aquifex
aeolicus)
PF00072
(Response_reg)
5 ALA A  90
LEU A  50
LEU A  63
ILE A  62
LEU A  54
None
PHD  A  51 ( 3.8A)
None
None
PHD  A  51 ( 4.3A)
1.17A 1xdkB-1zy2A:
undetectable
1xdkB-1zy2A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a6c HELIX-TURN-HELIX
MOTIF


(Nitrosomonas
europaea)
PF13744
(HTH_37)
5 LEU A  11
LEU A  52
ILE A  56
ILE A  53
LEU A  39
None
1.03A 1xdkB-2a6cA:
undetectable
1xdkB-2a6cA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hmf PROBABLE
ASPARTOKINASE


(Methanocaldococcus
jannaschii)
PF00696
(AA_kinase)
PF01842
(ACT)
PF13840
(ACT_7)
5 PHE A  68
ALA A  48
LEU A 132
ILE A 125
ARG A 122
None
1.00A 1xdkB-2hmfA:
undetectable
1xdkB-2hmfA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnh DNA POLYMERASE III
ALPHA SUBUNIT


(Escherichia
coli)
PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6)
5 LEU A  97
LEU A 100
ILE A 101
ARG A 107
LEU A 128
None
0.93A 1xdkB-2hnhA:
undetectable
1xdkB-2hnhA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5c PLECKSTRIN

(Homo sapiens)
PF00169
(PH)
5 ALA A 341
LEU A 275
LEU A 268
LEU A 327
LEU A 292
None
1.18A 1xdkB-2i5cA:
undetectable
1xdkB-2i5cA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oew PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN


(Homo sapiens)
PF03097
(BRO1)
5 PHE A  93
ILE A  78
ILE A  75
SER A 121
LEU A  21
None
1.10A 1xdkB-2oewA:
undetectable
1xdkB-2oewA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1n TRANSPORT INHIBITOR
RESPONSE 1 PROTEIN


(Arabidopsis
thaliana)
PF12937
(F-box-like)
5 ALA B 152
LEU B 189
ILE B 191
LEU B 203
LEU B 186
None
0.99A 1xdkB-2p1nB:
undetectable
1xdkB-2p1nB:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pb0 ACETYLORNITHINE/SUCC
INYLDIAMINOPIMELATE
AMINOTRANSFERASE


(Salmonella
enterica)
PF00202
(Aminotran_3)
5 PHE A 378
LEU A 346
ILE A 331
ILE A 325
PHE A 396
None
1.16A 1xdkB-2pb0A:
undetectable
1xdkB-2pb0A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2plg TLL0839 PROTEIN

(Synechococcus
elongatus)
PF10722
(YbjN)
5 ALA A 119
LEU A 134
ILE A 131
ILE A 135
LEU A  65
None
1.03A 1xdkB-2plgA:
undetectable
1xdkB-2plgA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w5f ENDO-1,4-BETA-XYLANA
SE Y


(Ruminiclostridium
thermocellum)
PF00331
(Glyco_hydro_10)
PF02018
(CBM_4_9)
5 PHE A 203
ALA A 486
ILE A 538
LEU A 195
LEU A 461
None
1.11A 1xdkB-2w5fA:
undetectable
1xdkB-2w5fA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w9f CELL DIVISION
PROTEIN KINASE 4


(Homo sapiens)
PF00069
(Pkinase)
5 CYH B 202
LEU B 273
LEU B 276
ILE B 230
ILE B 226
None
1.14A 1xdkB-2w9fB:
undetectable
1xdkB-2w9fB:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wvl MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE


(Thermus
thermophilus)
PF09488
(Osmo_MPGsynth)
5 ALA A 155
LEU A 369
LEU A 152
ILE A 149
LEU A 125
None
1.25A 1xdkB-2wvlA:
undetectable
1xdkB-2wvlA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahm OLIGOPEPTIDASE

(Geobacillus sp.
MO-1)
no annotation 5 PHE A 498
ALA A 417
LEU A 251
ILE A 247
ILE A 244
None
1.22A 1xdkB-3ahmA:
undetectable
1xdkB-3ahmA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwx ALPHA/BETA HYDROLASE

(Novosphingobium
aromaticivorans)
PF12697
(Abhydrolase_6)
5 ALA A 116
ILE A 121
PHE A  98
LEU A  32
LEU A  83
None
1.13A 1xdkB-3bwxA:
undetectable
1xdkB-3bwxA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7n NUCLEOPORIN NUP120

(Saccharomyces
cerevisiae)
PF11715
(Nup160)
5 LEU A 574
ILE A 579
PHE A 637
LEU A 642
LEU A 570
None
0.98A 1xdkB-3h7nA:
undetectable
1xdkB-3h7nA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i7f ASPARTYL-TRNA
SYNTHETASE


(Entamoeba
histolytica)
PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
5 LEU A 419
LEU A 422
ILE A 423
LEU A 389
LEU A 398
None
1.04A 1xdkB-3i7fA:
undetectable
1xdkB-3i7fA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihu TRANSCRIPTIONAL
REGULATOR, GNTR
FAMILY


(Cupriavidus
pinatubonensis)
PF00392
(GntR)
PF07729
(FCD)
5 ALA A  58
LEU A  39
ILE A  78
ILE A  67
LEU A  44
None
0.85A 1xdkB-3ihuA:
undetectable
1xdkB-3ihuA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jvv TWITCHING MOBILITY
PROTEIN


(Pseudomonas
aeruginosa)
PF00437
(T2SSE)
5 LEU A  50
ILE A  51
ILE A  54
PHE A  96
LEU A  42
None
0.88A 1xdkB-3jvvA:
undetectable
1xdkB-3jvvA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kba PROGESTERONE
RECEPTOR


(Homo sapiens)
PF00104
(Hormone_recep)
5 LEU A 824
LEU A 852
ILE A 849
ILE A 853
LEU A 877
None
1.23A 1xdkB-3kbaA:
20.6
1xdkB-3kbaA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll3 GLUCONATE KINASE

(Lactobacillus
acidophilus)
PF00370
(FGGY_N)
PF02782
(FGGY_C)
5 LEU A 378
ILE A 374
ILE A 371
ARG A 368
LEU A 255
None
1.03A 1xdkB-3ll3A:
undetectable
1xdkB-3ll3A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lov PROTOPORPHYRINOGEN
OXIDASE


(Exiguobacterium
sibiricum)
PF01593
(Amino_oxidase)
5 ALA A  17
LEU A  68
LEU A  71
ILE A  72
LEU A 234
None
0.91A 1xdkB-3lovA:
undetectable
1xdkB-3lovA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lwj PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR


(Syntrophomonas
wolfei)
PF00440
(TetR_N)
5 LEU A  62
LEU A  59
ILE A  58
SER A 116
LEU A 105
None
0.95A 1xdkB-3lwjA:
undetectable
1xdkB-3lwjA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o82 PEPTIDE ARYLATION
ENZYME


(Acinetobacter
baumannii)
PF00501
(AMP-binding)
5 LEU A 128
ILE A 130
ARG A 133
LEU A  66
LEU A  75
None
1.12A 1xdkB-3o82A:
undetectable
1xdkB-3o82A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4


(Saccharomyces
cerevisiae)
PF11701
(UNC45-central)
5 LEU A 693
ILE A 694
ILE A 698
PHE A 718
LEU A 721
None
0.72A 1xdkB-3opbA:
undetectable
1xdkB-3opbA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdi NITROGENASE MOFE
COFACTOR
BIOSYNTHESIS PROTEIN
NIFN


(Azotobacter
vinelandii)
PF00148
(Oxidored_nitro)
5 ALA B 280
LEU B 268
ILE B 188
ILE B 192
SER B 285
None
1.24A 1xdkB-3pdiB:
undetectable
1xdkB-3pdiB:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pih UVRABC SYSTEM
PROTEIN A


(Thermotoga
maritima)
PF00005
(ABC_tran)
5 LEU A 139
LEU A 136
ILE A 135
ILE A 132
LEU A 210
None
0.69A 1xdkB-3pihA:
undetectable
1xdkB-3pihA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3


(Mus musculus)
PF00069
(Pkinase)
5 ALA B 922
LEU B1008
ILE B1069
ILE B1070
LEU B 936
None
1.20A 1xdkB-3qd2B:
undetectable
1xdkB-3qd2B:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rre PUTATIVE
UNCHARACTERIZED
PROTEIN


(Thermotoga
maritima)
PF01256
(Carb_kinase)
PF03853
(YjeF_N)
5 LEU A 477
LEU A 480
ILE A 481
ARG A 486
LEU A 472
None
0.82A 1xdkB-3rreA:
undetectable
1xdkB-3rreA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr8 OLIGORIBONUCLEASE

(Coxiella
burnetii)
PF00929
(RNase_T)
5 ALA A  45
LEU A  71
ILE A  26
ILE A  48
LEU A 159
None
1.11A 1xdkB-3tr8A:
undetectable
1xdkB-3tr8A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tzg HYPOTHETICAL PROTEIN
BVU_2266


(Bacteroides
vulgatus)
no annotation 5 LEU A  47
ILE A  55
ARG A  64
PHE A 206
LEU A 209
None
0.99A 1xdkB-3tzgA:
undetectable
1xdkB-3tzgA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vay HAD-SUPERFAMILY
HYDROLASE


(Pseudomonas
syringae group
genomosp. 3)
PF13419
(HAD_2)
5 ALA A  90
LEU A  38
LEU A  76
LEU A  46
LEU A  31
None
1.21A 1xdkB-3vayA:
undetectable
1xdkB-3vayA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4df9 PUTATIVE PEPTIDASE

(Bacteroides
fragilis)
PF09471
(Peptidase_M64)
PF16217
(M64_N)
5 PHE A 193
ALA A 221
LEU A 269
ILE A 277
ILE A 278
None
1.04A 1xdkB-4df9A:
undetectable
1xdkB-4df9A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dq1 THYMIDYLATE SYNTHASE

(Staphylococcus
aureus)
PF00303
(Thymidylat_synt)
5 LEU A 239
LEU A 242
ILE A 243
LEU A 167
LEU A  64
None
0.91A 1xdkB-4dq1A:
undetectable
1xdkB-4dq1A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dq1 THYMIDYLATE SYNTHASE

(Staphylococcus
aureus)
PF00303
(Thymidylat_synt)
5 LEU A 239
LEU A 242
ILE A 243
SER A 289
LEU A 167
None
1.15A 1xdkB-4dq1A:
undetectable
1xdkB-4dq1A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3


(Homo sapiens)
PF00069
(Pkinase)
5 ALA A 923
LEU A1009
ILE A1070
ILE A1071
LEU A 937
None
1.09A 1xdkB-4g34A:
undetectable
1xdkB-4g34A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gq2 NUCLEOPORIN NUP120

(Schizosaccharomyces
pombe)
PF11715
(Nup160)
5 LEU M 652
ILE M 649
ILE M 653
SER M 658
LEU M 698
None
1.07A 1xdkB-4gq2M:
undetectable
1xdkB-4gq2M:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gx8 DNA POLYMERASE III
SUBUNIT EPSILON,DNA
POLYMERASE III
SUBUNIT ALPHA


(Escherichia
coli)
PF02811
(PHP)
5 LEU A 142
LEU A 145
ILE A 146
ARG A 152
LEU A 173
None
0.92A 1xdkB-4gx8A:
undetectable
1xdkB-4gx8A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hz8 BETA-GLUCOSIDASE

(uncultured
bacterium)
PF00232
(Glyco_hydro_1)
5 LEU A 289
LEU A 292
ILE A 293
LEU A 381
LEU A 259
None
0.93A 1xdkB-4hz8A:
undetectable
1xdkB-4hz8A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4isa UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE


(Escherichia
coli)
PF03331
(LpxC)
5 ALA A  52
LEU A  80
ILE A 101
ILE A  74
LEU A  84
None
1.03A 1xdkB-4isaA:
undetectable
1xdkB-4isaA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1


(Arabidopsis
thaliana)
PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8)
5 LEU A 556
ILE A 552
ILE A 576
LEU A 567
LEU A 562
None
1.01A 1xdkB-4m7eA:
undetectable
1xdkB-4m7eA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mt1 DRUG EFFLUX PROTEIN

(Neisseria
gonorrhoeae)
PF00873
(ACR_tran)
5 ALA A 795
LEU A 798
ILE A 743
ILE A 738
SER A 792
None
1.15A 1xdkB-4mt1A:
undetectable
1xdkB-4mt1A:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbo STEROID RECEPTOR RNA
ACTIVATOR 1


(Homo sapiens)
PF07304
(SRA1)
5 CYH A 125
LEU A 201
ILE A 202
LEU A 164
LEU A 141
None
1.25A 1xdkB-4nboA:
undetectable
1xdkB-4nboA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nmn REPLICATIVE DNA
HELICASE


(Aquifex
aeolicus)
PF00772
(DnaB)
PF03796
(DnaB_C)
5 LEU A 189
ILE A 413
ILE A 412
ARG A 369
LEU A 387
None
1.07A 1xdkB-4nmnA:
undetectable
1xdkB-4nmnA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4okq HUT OPERON POSITIVE
REGULATORY PROTEIN


(Geobacillus
thermodenitrificans)
PF09021
(HutP)
5 ALA A 106
LEU A 144
ILE A 146
ILE A 122
LEU A  14
None
1.13A 1xdkB-4okqA:
undetectable
1xdkB-4okqA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q22 GLYCOSIDE HYDROLASE
FAMILY 18


(Serratia
proteamaculans)
PF00704
(Glyco_hydro_18)
5 LEU A 271
LEU A 219
SER A 200
LEU A 235
LEU A 389
None
1.04A 1xdkB-4q22A:
undetectable
1xdkB-4q22A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvw ZNUD

(Neisseria
meningitidis)
PF00593
(TonB_dep_Rec)
PF07715
(Plug)
5 ALA A 135
LEU A  42
ILE A  37
ILE A  36
LEU A  53
None
1.18A 1xdkB-4rvwA:
undetectable
1xdkB-4rvwA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u7l LEUCINE-RICH REPEATS
AND
IMMUNOGLOBULIN-LIKE
DOMAINS PROTEIN 1


(Homo sapiens)
PF01463
(LRRCT)
PF13855
(LRR_8)
5 ALA A 142
LEU A 128
ILE A 125
LEU A  95
LEU A 130
None
1.21A 1xdkB-4u7lA:
undetectable
1xdkB-4u7lA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uy6 HISTIDINE-SPECIFIC
METHYLTRANSFERASE
EGTD


(Mycolicibacterium
smegmatis)
PF10017
(Methyltransf_33)
5 ALA A  76
LEU A 190
LEU A 318
LEU A  66
LEU A 156
None
1.01A 1xdkB-4uy6A:
undetectable
1xdkB-4uy6A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v08 UL26

(Suid
alphaherpesvirus
1)
PF00716
(Peptidase_S21)
5 LEU A  73
ILE A  49
ILE A  39
LEU A 105
LEU A  97
None
1.17A 1xdkB-4v08A:
undetectable
1xdkB-4v08A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjg HAPTOGLOBIN

(Homo sapiens)
no annotation 5 ALA C 173
ILE C 188
SER C 278
LEU C 245
LEU C 248
None
1.05A 1xdkB-4wjgC:
undetectable
1xdkB-4wjgC:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjg HAPTOGLOBIN

(Homo sapiens)
no annotation 5 ALA C 173
LEU C 187
ILE C 188
LEU C 245
LEU C 248
None
1.15A 1xdkB-4wjgC:
undetectable
1xdkB-4wjgC:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xh9 NEUROEPITHELIAL
CELL-TRANSFORMING
GENE 1 PROTEIN


(Homo sapiens)
PF00169
(PH)
PF00621
(RhoGEF)
5 CYH A 495
LEU A 410
LEU A 405
ILE A 403
LEU A 436
None
1.23A 1xdkB-4xh9A:
undetectable
1xdkB-4xh9A:
26.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0c TOLL-LIKE RECEPTOR
13


(Mus musculus)
PF00560
(LRR_1)
PF13516
(LRR_6)
PF13855
(LRR_8)
5 PHE A 589
LEU A 626
ILE A 607
ILE A 576
PHE A 614
None
0.89A 1xdkB-4z0cA:
undetectable
1xdkB-4z0cA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7g IPT/TIG
DOMAIN-CONTAINING
PROTEIN BACOVA_02650


(Bacteroides
ovatus)
no annotation 5 PHE A 160
LEU A 212
ILE A 141
ILE A 156
LEU A 200
None
1.07A 1xdkB-5e7gA:
undetectable
1xdkB-5e7gA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fku DNA POLYMERASE III
SUBUNIT ALPHA


(Escherichia
coli)
PF01336
(tRNA_anti-codon)
PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6)
5 LEU A  97
LEU A 100
ILE A 101
ARG A 107
LEU A 128
None
0.90A 1xdkB-5fkuA:
undetectable
1xdkB-5fkuA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5p NUCLEAR MRNA EXPORT
PROTEIN SAC3


(Saccharomyces
cerevisiae)
PF03399
(SAC3_GANP)
5 LEU A 508
ILE A 498
ILE A 500
PHE A 474
LEU A 477
None
1.22A 1xdkB-5g5pA:
undetectable
1xdkB-5g5pA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdh TOLL-LIKE RECEPTOR 8

(Homo sapiens)
PF13855
(LRR_8)
5 PHE A 242
LEU A 294
ILE A 276
ILE A 234
LEU A 292
None
1.08A 1xdkB-5hdhA:
undetectable
1xdkB-5hdhA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2g DIOL DEHYDRATASE

(Roseburia
inulinivorans)
PF01228
(Gly_radical)
PF02901
(PFL-like)
5 LEU A 315
ILE A 316
ILE A 319
LEU A 363
LEU A 307
None
0.91A 1xdkB-5i2gA:
1.4
1xdkB-5i2gA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j7w THYMIDYLATE SYNTHASE

(Enterococcus
faecalis)
PF00303
(Thymidylat_synt)
5 LEU A 235
LEU A 238
ILE A 239
LEU A 163
LEU A  60
None
0.96A 1xdkB-5j7wA:
undetectable
1xdkB-5j7wA:
22.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5k13 RETINOIC ACID
RECEPTOR ALPHA


(Homo sapiens)
PF00104
(Hormone_recep)
7 PHE A 228
CYH A 235
LEU A 266
LEU A 269
ILE A 270
ARG A 276
PHE A 302
6Q7  A 501 (-3.9A)
6Q7  A 501 ( 3.7A)
6Q7  A 501 (-4.2A)
6Q7  A 501 (-3.7A)
6Q7  A 501 (-4.8A)
6Q7  A 501 (-3.2A)
6Q7  A 501 ( 4.3A)
0.68A 1xdkB-5k13A:
35.3
1xdkB-5k13A:
78.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5k13 RETINOIC ACID
RECEPTOR ALPHA


(Homo sapiens)
PF00104
(Hormone_recep)
7 PHE A 228
CYH A 235
LEU A 266
LEU A 269
ILE A 270
SER A 287
PHE A 302
6Q7  A 501 (-3.9A)
6Q7  A 501 ( 3.7A)
6Q7  A 501 (-4.2A)
6Q7  A 501 (-3.7A)
6Q7  A 501 (-4.8A)
6Q7  A 501 (-2.9A)
6Q7  A 501 ( 4.3A)
0.80A 1xdkB-5k13A:
35.3
1xdkB-5k13A:
78.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5k13 RETINOIC ACID
RECEPTOR ALPHA


(Homo sapiens)
PF00104
(Hormone_recep)
7 PHE A 228
CYH A 235
LEU A 269
ILE A 270
ILE A 273
ARG A 276
PHE A 302
6Q7  A 501 (-3.9A)
6Q7  A 501 ( 3.7A)
6Q7  A 501 (-3.7A)
6Q7  A 501 (-4.8A)
6Q7  A 501 ( 3.9A)
6Q7  A 501 (-3.2A)
6Q7  A 501 ( 4.3A)
0.60A 1xdkB-5k13A:
35.3
1xdkB-5k13A:
78.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5k13 RETINOIC ACID
RECEPTOR ALPHA


(Homo sapiens)
PF00104
(Hormone_recep)
7 PHE A 228
CYH A 235
LEU A 269
ILE A 270
ILE A 273
SER A 287
PHE A 302
6Q7  A 501 (-3.9A)
6Q7  A 501 ( 3.7A)
6Q7  A 501 (-3.7A)
6Q7  A 501 (-4.8A)
6Q7  A 501 ( 3.9A)
6Q7  A 501 (-2.9A)
6Q7  A 501 ( 4.3A)
0.71A 1xdkB-5k13A:
35.3
1xdkB-5k13A:
78.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3t NUCLEAR MRNA EXPORT
PROTEIN SAC3


(Saccharomyces
cerevisiae)
PF03399
(SAC3_GANP)
5 LEU A 508
ILE A 498
ILE A 500
PHE A 474
LEU A 477
None
1.22A 1xdkB-5l3tA:
undetectable
1xdkB-5l3tA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n5z RNA POLYMERASE
I-SPECIFIC
TRANSCRIPTION
INITIATION FACTOR
RRN3


(Saccharomyces
cerevisiae)
PF05327
(RRN3)
5 ALA O 476
LEU O 446
ARG O 452
PHE O 505
LEU O 502
None
1.25A 1xdkB-5n5zO:
undetectable
1xdkB-5n5zO:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nij VACUOLAR-PROCESSING
ENZYME GAMMA-ISOZYME


(Arabidopsis
thaliana)
no annotation 5 PHE A 225
LEU A 191
LEU A 183
SER A 241
PHE A 214
None
1.17A 1xdkB-5nijA:
undetectable
1xdkB-5nijA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5npy FLAGELLAR BASAL BODY
PROTEIN


(Helicobacter
pylori)
no annotation 5 LEU A 310
ILE A 352
SER A 382
PHE A 212
LEU A 294
None
1.00A 1xdkB-5npyA:
undetectable
1xdkB-5npyA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqd ARSENITE OXIDASE
LARGE SUBUNIT AIOA
[3FE-4S] CLUSTER,
MO-MOLYBDOPTERIN
COFACTOR-BINDING
ACTIVE SITE


(Rhizobium sp.
NT-26)
no annotation 5 LEU A 303
ILE A 278
PHE A 314
LEU A 317
LEU A 383
None
1.13A 1xdkB-5nqdA:
undetectable
1xdkB-5nqdA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5obt VACUOLAR-PROCESSING
ENZYME GAMMA-ISOZYME


(Arabidopsis
thaliana)
no annotation 5 PHE A 225
LEU A 191
LEU A 183
SER A 241
PHE A 214
None
1.11A 1xdkB-5obtA:
undetectable
1xdkB-5obtA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oqd POLYCOMB PROTEIN PCL

(Drosophila
melanogaster)
no annotation 5 LEU B 585
ILE B 603
ILE B 607
LEU B 636
LEU B 658
None
1.15A 1xdkB-5oqdB:
undetectable
1xdkB-5oqdB:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1s SEPARIN

(Saccharomyces
cerevisiae)
PF03568
(Peptidase_C50)
5 LEU A1344
ILE A1345
SER A 998
PHE A1296
LEU A1330
None
0.85A 1xdkB-5u1sA:
undetectable
1xdkB-5u1sA:
11.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uan RETINOIC ACID
RECEPTOR BETA


(Homo sapiens)
no annotation 12 PHE B 221
ALA B 225
CYH B 228
LEU B 259
LEU B 262
ILE B 263
ILE B 266
ARG B 269
SER B 280
PHE B 295
LEU B 298
LEU B 407
REA  B 503 ( 4.8A)
REA  B 503 (-3.8A)
REA  B 503 (-3.1A)
None
REA  B 503 (-3.9A)
REA  B 503 (-4.4A)
REA  B 503 (-3.6A)
REA  B 503 ( 4.8A)
REA  B 503 (-2.1A)
REA  B 503 ( 4.0A)
None
None
0.44A 1xdkB-5uanB:
38.3
1xdkB-5uanB:
98.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubp LEUCINE PERMEASE
TRANSCRIPTIONAL
REGULATOR


(Saccharomyces
cerevisiae)
PF03399
(SAC3_GANP)
5 LEU A 508
ILE A 498
ILE A 500
PHE A 474
LEU A 477
None
1.22A 1xdkB-5ubpA:
undetectable
1xdkB-5ubpA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ui5 RNA POLYMERASE SIGMA
FACTOR RPON


(Aquifex
aeolicus)
PF04552
(Sigma54_DBD)
PF04963
(Sigma54_CBD)
5 LEU I 343
LEU I 346
ILE I 347
ILE I 350
LEU I 338
None
0.64A 1xdkB-5ui5I:
undetectable
1xdkB-5ui5I:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uib OXIDOREDUCTASE
PROTEIN


(Agrobacterium
tumefaciens)
PF01408
(GFO_IDH_MocA)
5 ALA A 187
LEU A 197
LEU A 218
ILE A 227
LEU A 325
None
1.21A 1xdkB-5uibA:
undetectable
1xdkB-5uibA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xsy SODIUM CHANNEL
PROTEIN


(Electrophorus
electricus)
PF00520
(Ion_trans)
PF06512
(Na_trans_assoc)
5 ALA A1108
LEU A1457
LEU A1460
ILE A1461
ILE A1464
None
0.98A 1xdkB-5xsyA:
undetectable
1xdkB-5xsyA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyh CBSA

(Xanthomonas
oryzae)
no annotation 5 LEU A 122
ILE A 173
ILE A 217
LEU A 105
LEU A  83
None
0.97A 1xdkB-5xyhA:
undetectable
1xdkB-5xyhA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bb9 4-AMINO-4-DEOXYCHORI
SMATE LYASE


(Salmonella
enterica)
no annotation 5 ILE A 234
ILE A 242
ARG A 117
SER A 114
LEU A 123
None
1.15A 1xdkB-6bb9A:
undetectable
1xdkB-6bb9A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c90 EXOSOME RNA HELICASE
MTR4,EXOSOME RNA
HELICASE MTR4


(Homo sapiens)
no annotation 5 LEU A 236
LEU A 232
ILE A 231
SER A 195
LEU A 273
None
1.25A 1xdkB-6c90A:
undetectable
1xdkB-6c90A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F


(Pyrococcus
furiosus)
no annotation 5 ALA B  13
LEU B  37
LEU B  40
ILE B  41
LEU D  52
None
1.12A 1xdkB-6cfwB:
undetectable
1xdkB-6cfwB:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F


(Pyrococcus
furiosus)
no annotation 5 ALA B  13
LEU B  37
LEU B  40
ILE B  44
LEU D  52
None
1.10A 1xdkB-6cfwB:
undetectable
1xdkB-6cfwB:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ehs HYDROGENASE-2 LARGE
CHAIN


(Escherichia
coli)
no annotation 5 ALA L  97
LEU L 208
ILE L 243
ILE L 247
LEU L 446
None
0.79A 1xdkB-6ehsL:
undetectable
1xdkB-6ehsL:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fx0 RETINOIC ACID
RECEPTOR GAMMA


(Homo sapiens)
no annotation 9 PHE A 230
ALA A 234
CYH A 237
LEU A 268
LEU A 271
ILE A 275
ARG A 278
SER A 289
PHE A 304
E9T  A 501 (-4.3A)
E9T  A 501 (-3.7A)
E9T  A 501 (-3.6A)
E9T  A 501 (-4.9A)
E9T  A 501 (-3.6A)
E9T  A 501 (-3.8A)
E9T  A 501 (-3.1A)
E9T  A 501 (-2.6A)
E9T  A 501 (-4.2A)
0.56A 1xdkB-6fx0A:
37.1
1xdkB-6fx0A:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fx0 RETINOIC ACID
RECEPTOR GAMMA


(Homo sapiens)
no annotation 9 PHE A 230
ALA A 234
CYH A 237
LEU A 271
ILE A 275
ARG A 278
SER A 289
PHE A 304
LEU A 307
E9T  A 501 (-4.3A)
E9T  A 501 (-3.7A)
E9T  A 501 (-3.6A)
E9T  A 501 (-3.6A)
E9T  A 501 (-3.8A)
E9T  A 501 (-3.1A)
E9T  A 501 (-2.6A)
E9T  A 501 (-4.2A)
None
0.62A 1xdkB-6fx0A:
37.1
1xdkB-6fx0A:
15.51