SIMILAR PATTERNS OF AMINO ACIDS FOR 1XDK_B_9CRB600_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dnp | DNA PHOTOLYASE (Escherichiacoli) |
PF00875(DNA_photolyase)PF03441(FAD_binding_7) | 5 | LEU A 272LEU A 275ILE A 276LEU A 158LEU A 255 | NoneFAD A 472 ( 4.7A)NoneNoneNone | 1.26A | 1xdkB-1dnpA:0.0 | 1xdkB-1dnpA:20.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e1k | ADRENODOXINREDUCTASE (Bos taurus) |
PF07992(Pyr_redox_2) | 5 | LEU A 210ILE A 194SER A 328LEU A 223LEU A 245 | NoneNoneNAP A 802 (-4.1A)NoneNone | 0.97A | 1xdkB-1e1kA:undetectable | 1xdkB-1e1kA:21.98 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1exx | RETINOIC ACIDRECEPTOR GAMMA-2 (Homo sapiens) |
PF00104(Hormone_recep) | 9 | PHE A 230ALA A 234CYH A 237LEU A 268LEU A 271ILE A 275ARG A 278SER A 289PHE A 304 | 961 A 450 (-3.9A)961 A 450 (-3.1A)961 A 450 (-3.6A)961 A 450 ( 4.9A)961 A 450 (-3.6A)961 A 450 (-3.5A)961 A 450 (-3.6A)961 A 450 (-2.5A)961 A 450 (-3.6A) | 0.54A | 1xdkB-1exxA:37.3 | 1xdkB-1exxA:81.61 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1exx | RETINOIC ACIDRECEPTOR GAMMA-2 (Homo sapiens) |
PF00104(Hormone_recep) | 5 | PHE A 230ALA A 234CYH A 237PHE A 304LEU A 268 | 961 A 450 (-3.9A)961 A 450 (-3.1A)961 A 450 (-3.6A)961 A 450 (-3.6A)961 A 450 ( 4.9A) | 1.13A | 1xdkB-1exxA:37.3 | 1xdkB-1exxA:81.61 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1exx | RETINOIC ACIDRECEPTOR GAMMA-2 (Homo sapiens) |
PF00104(Hormone_recep) | 7 | PHE A 230ALA A 234ILE A 275ARG A 278SER A 289PHE A 304LEU A 307 | 961 A 450 (-3.9A)961 A 450 (-3.1A)961 A 450 (-3.5A)961 A 450 (-3.6A)961 A 450 (-2.5A)961 A 450 (-3.6A)961 A 450 (-4.8A) | 0.55A | 1xdkB-1exxA:37.3 | 1xdkB-1exxA:81.61 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1exx | RETINOIC ACIDRECEPTOR GAMMA-2 (Homo sapiens) |
PF00104(Hormone_recep) | 5 | PHE A 230ALA A 234PHE A 304LEU A 307LEU A 268 | 961 A 450 (-3.9A)961 A 450 (-3.1A)961 A 450 (-3.6A)961 A 450 (-4.8A)961 A 450 ( 4.9A) | 1.02A | 1xdkB-1exxA:37.3 | 1xdkB-1exxA:81.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gz0 | HYPOTHETICALTRNA/RRNAMETHYLTRANSFERASEYJFH (Escherichiacoli) |
PF00588(SpoU_methylase)PF08032(SpoU_sub_bind) | 5 | ALA A 72LEU A 39ILE A 8SER A 62LEU A 43 | None | 0.86A | 1xdkB-1gz0A:undetectable | 1xdkB-1gz0A:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1seh | DEOXYURIDINE5'-TRIPHOSPHATENUCLEOTIDOHYDROLASE (Escherichiacoli) |
PF00692(dUTPase) | 5 | LEU A 97ILE A 89ILE A 59PHE A 122LEU A 55 | UMP A 777 (-4.7A)UMP A 777 (-3.9A)NoneNoneNone | 1.22A | 1xdkB-1sehA:undetectable | 1xdkB-1sehA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sxj | ACTIVATOR 1 41 KDASUBUNIT (Saccharomycescerevisiae) |
PF00004(AAA)PF08542(Rep_fac_C) | 5 | PHE D 189ALA D 45LEU D 36LEU D 49SER D 185 | None | 1.26A | 1xdkB-1sxjD:undetectable | 1xdkB-1sxjD:24.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t90 | PROBABLEMETHYLMALONATE-SEMIALDEHYDEDEHYDROGENASE (Bacillussubtilis) |
PF00171(Aldedh) | 5 | PHE A 163LEU A 86PHE A 75LEU A 191LEU A 184 | None | 1.11A | 1xdkB-1t90A:undetectable | 1xdkB-1t90A:19.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ukf | AVIRULENCE PROTEINAVRPPH3 (Pseudomonassavastanoi) |
PF03543(Peptidase_C58) | 5 | LEU A 225ILE A 244ILE A 248SER A 253LEU A 202 | None | 0.90A | 1xdkB-1ukfA:0.0 | 1xdkB-1ukfA:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1upr | PLECKSTRIN HOMOLOGYDOMAIN-CONTAININGFAMILY A MEMBER 4 (Homo sapiens) |
PF00169(PH) | 5 | ALA A1147LEU A1084LEU A1079LEU A1133LEU A1101 | None | 1.16A | 1xdkB-1uprA:0.0 | 1xdkB-1uprA:16.07 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1xap | RETINOIC ACIDRECEPTOR BETA (Homo sapiens) |
PF00104(Hormone_recep) | 10 | PHE A 221ALA A 225CYH A 228LEU A 259LEU A 262ILE A 263ILE A 266ARG A 269SER A 280PHE A 295 | TTB A 1 (-4.7A)TTB A 1 (-4.0A)TTB A 1 ( 3.8A)TTB A 1 ( 4.9A)TTB A 1 (-3.9A)TTB A 1 ( 4.9A)TTB A 1 ( 4.0A)TTB A 1 (-3.3A)TTB A 1 (-3.1A)TTB A 1 ( 4.1A) | 0.46A | 1xdkB-1xapA:37.1 | 1xdkB-1xapA:92.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y8t | HYPOTHETICAL PROTEINRV0983 (Mycobacteriumtuberculosis) |
PF13180(PDZ_2)PF13365(Trypsin_2) | 5 | ALA A 217LEU A 38ILE A 37ILE A 44LEU A 105 | None | 1.24A | 1xdkB-1y8tA:undetectable | 1xdkB-1y8tA:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y9q | TRANSCRIPTIONALREGULATOR, HTH_3FAMILY (Vibrio cholerae) |
PF01381(HTH_3) | 5 | LEU A 19LEU A 16ILE A 12SER A 49LEU A 63 | None | 1.04A | 1xdkB-1y9qA:undetectable | 1xdkB-1y9qA:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zy2 | TRANSCRIPTIONALREGULATOR NTRC1 (Aquifexaeolicus) |
PF00072(Response_reg) | 5 | ALA A 90LEU A 50LEU A 63ILE A 62LEU A 54 | NonePHD A 51 ( 3.8A)NoneNonePHD A 51 ( 4.3A) | 1.17A | 1xdkB-1zy2A:undetectable | 1xdkB-1zy2A:19.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a6c | HELIX-TURN-HELIXMOTIF (Nitrosomonaseuropaea) |
PF13744(HTH_37) | 5 | LEU A 11LEU A 52ILE A 56ILE A 53LEU A 39 | None | 1.03A | 1xdkB-2a6cA:undetectable | 1xdkB-2a6cA:14.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hmf | PROBABLEASPARTOKINASE (Methanocaldococcusjannaschii) |
PF00696(AA_kinase)PF01842(ACT)PF13840(ACT_7) | 5 | PHE A 68ALA A 48LEU A 132ILE A 125ARG A 122 | None | 1.00A | 1xdkB-2hmfA:undetectable | 1xdkB-2hmfA:23.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hnh | DNA POLYMERASE IIIALPHA SUBUNIT (Escherichiacoli) |
PF02811(PHP)PF07733(DNA_pol3_alpha)PF14579(HHH_6) | 5 | LEU A 97LEU A 100ILE A 101ARG A 107LEU A 128 | None | 0.93A | 1xdkB-2hnhA:undetectable | 1xdkB-2hnhA:16.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i5c | PLECKSTRIN (Homo sapiens) |
PF00169(PH) | 5 | ALA A 341LEU A 275LEU A 268LEU A 327LEU A 292 | None | 1.18A | 1xdkB-2i5cA:undetectable | 1xdkB-2i5cA:16.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oew | PROGRAMMED CELLDEATH 6-INTERACTINGPROTEIN (Homo sapiens) |
PF03097(BRO1) | 5 | PHE A 93ILE A 78ILE A 75SER A 121LEU A 21 | None | 1.10A | 1xdkB-2oewA:undetectable | 1xdkB-2oewA:20.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p1n | TRANSPORT INHIBITORRESPONSE 1 PROTEIN (Arabidopsisthaliana) |
PF12937(F-box-like) | 5 | ALA B 152LEU B 189ILE B 191LEU B 203LEU B 186 | None | 0.99A | 1xdkB-2p1nB:undetectable | 1xdkB-2p1nB:21.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pb0 | ACETYLORNITHINE/SUCCINYLDIAMINOPIMELATEAMINOTRANSFERASE (Salmonellaenterica) |
PF00202(Aminotran_3) | 5 | PHE A 378LEU A 346ILE A 331ILE A 325PHE A 396 | None | 1.16A | 1xdkB-2pb0A:undetectable | 1xdkB-2pb0A:19.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2plg | TLL0839 PROTEIN (Synechococcuselongatus) |
PF10722(YbjN) | 5 | ALA A 119LEU A 134ILE A 131ILE A 135LEU A 65 | None | 1.03A | 1xdkB-2plgA:undetectable | 1xdkB-2plgA:18.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w5f | ENDO-1,4-BETA-XYLANASE Y (Ruminiclostridiumthermocellum) |
PF00331(Glyco_hydro_10)PF02018(CBM_4_9) | 5 | PHE A 203ALA A 486ILE A 538LEU A 195LEU A 461 | None | 1.11A | 1xdkB-2w5fA:undetectable | 1xdkB-2w5fA:19.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w9f | CELL DIVISIONPROTEIN KINASE 4 (Homo sapiens) |
PF00069(Pkinase) | 5 | CYH B 202LEU B 273LEU B 276ILE B 230ILE B 226 | None | 1.14A | 1xdkB-2w9fB:undetectable | 1xdkB-2w9fB:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wvl | MANNOSYL-3-PHOSPHOGLYCERATE SYNTHASE (Thermusthermophilus) |
PF09488(Osmo_MPGsynth) | 5 | ALA A 155LEU A 369LEU A 152ILE A 149LEU A 125 | None | 1.25A | 1xdkB-2wvlA:undetectable | 1xdkB-2wvlA:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ahm | OLIGOPEPTIDASE (Geobacillus sp.MO-1) |
no annotation | 5 | PHE A 498ALA A 417LEU A 251ILE A 247ILE A 244 | None | 1.22A | 1xdkB-3ahmA:undetectable | 1xdkB-3ahmA:20.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bwx | ALPHA/BETA HYDROLASE (Novosphingobiumaromaticivorans) |
PF12697(Abhydrolase_6) | 5 | ALA A 116ILE A 121PHE A 98LEU A 32LEU A 83 | None | 1.13A | 1xdkB-3bwxA:undetectable | 1xdkB-3bwxA:22.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h7n | NUCLEOPORIN NUP120 (Saccharomycescerevisiae) |
PF11715(Nup160) | 5 | LEU A 574ILE A 579PHE A 637LEU A 642LEU A 570 | None | 0.98A | 1xdkB-3h7nA:undetectable | 1xdkB-3h7nA:18.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i7f | ASPARTYL-TRNASYNTHETASE (Entamoebahistolytica) |
PF00152(tRNA-synt_2)PF01336(tRNA_anti-codon) | 5 | LEU A 419LEU A 422ILE A 423LEU A 389LEU A 398 | None | 1.04A | 1xdkB-3i7fA:undetectable | 1xdkB-3i7fA:19.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ihu | TRANSCRIPTIONALREGULATOR, GNTRFAMILY (Cupriaviduspinatubonensis) |
PF00392(GntR)PF07729(FCD) | 5 | ALA A 58LEU A 39ILE A 78ILE A 67LEU A 44 | None | 0.85A | 1xdkB-3ihuA:undetectable | 1xdkB-3ihuA:20.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jvv | TWITCHING MOBILITYPROTEIN (Pseudomonasaeruginosa) |
PF00437(T2SSE) | 5 | LEU A 50ILE A 51ILE A 54PHE A 96LEU A 42 | None | 0.88A | 1xdkB-3jvvA:undetectable | 1xdkB-3jvvA:23.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kba | PROGESTERONERECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 5 | LEU A 824LEU A 852ILE A 849ILE A 853LEU A 877 | None | 1.23A | 1xdkB-3kbaA:20.6 | 1xdkB-3kbaA:23.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ll3 | GLUCONATE KINASE (Lactobacillusacidophilus) |
PF00370(FGGY_N)PF02782(FGGY_C) | 5 | LEU A 378ILE A 374ILE A 371ARG A 368LEU A 255 | None | 1.03A | 1xdkB-3ll3A:undetectable | 1xdkB-3ll3A:22.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lov | PROTOPORPHYRINOGENOXIDASE (Exiguobacteriumsibiricum) |
PF01593(Amino_oxidase) | 5 | ALA A 17LEU A 68LEU A 71ILE A 72LEU A 234 | None | 0.91A | 1xdkB-3lovA:undetectable | 1xdkB-3lovA:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lwj | PUTATIVE TETR-FAMILYTRANSCRIPTIONALREGULATOR (Syntrophomonaswolfei) |
PF00440(TetR_N) | 5 | LEU A 62LEU A 59ILE A 58SER A 116LEU A 105 | None | 0.95A | 1xdkB-3lwjA:undetectable | 1xdkB-3lwjA:22.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o82 | PEPTIDE ARYLATIONENZYME (Acinetobacterbaumannii) |
PF00501(AMP-binding) | 5 | LEU A 128ILE A 130ARG A 133LEU A 66LEU A 75 | None | 1.12A | 1xdkB-3o82A:undetectable | 1xdkB-3o82A:18.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3opb | SWI5-DEPENDENT HOEXPRESSION PROTEIN 4 (Saccharomycescerevisiae) |
PF11701(UNC45-central) | 5 | LEU A 693ILE A 694ILE A 698PHE A 718LEU A 721 | None | 0.72A | 1xdkB-3opbA:undetectable | 1xdkB-3opbA:17.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pdi | NITROGENASE MOFECOFACTORBIOSYNTHESIS PROTEINNIFN (Azotobactervinelandii) |
PF00148(Oxidored_nitro) | 5 | ALA B 280LEU B 268ILE B 188ILE B 192SER B 285 | None | 1.24A | 1xdkB-3pdiB:undetectable | 1xdkB-3pdiB:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pih | UVRABC SYSTEMPROTEIN A (Thermotogamaritima) |
PF00005(ABC_tran) | 5 | LEU A 139LEU A 136ILE A 135ILE A 132LEU A 210 | None | 0.69A | 1xdkB-3pihA:undetectable | 1xdkB-3pihA:15.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qd2 | EUKARYOTICTRANSLATIONINITIATION FACTOR2-ALPHA KINASE 3 (Mus musculus) |
PF00069(Pkinase) | 5 | ALA B 922LEU B1008ILE B1069ILE B1070LEU B 936 | None | 1.20A | 1xdkB-3qd2B:undetectable | 1xdkB-3qd2B:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rre | PUTATIVEUNCHARACTERIZEDPROTEIN (Thermotogamaritima) |
PF01256(Carb_kinase)PF03853(YjeF_N) | 5 | LEU A 477LEU A 480ILE A 481ARG A 486LEU A 472 | None | 0.82A | 1xdkB-3rreA:undetectable | 1xdkB-3rreA:22.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tr8 | OLIGORIBONUCLEASE (Coxiellaburnetii) |
PF00929(RNase_T) | 5 | ALA A 45LEU A 71ILE A 26ILE A 48LEU A 159 | None | 1.11A | 1xdkB-3tr8A:undetectable | 1xdkB-3tr8A:20.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tzg | HYPOTHETICAL PROTEINBVU_2266 (Bacteroidesvulgatus) |
no annotation | 5 | LEU A 47ILE A 55ARG A 64PHE A 206LEU A 209 | None | 0.99A | 1xdkB-3tzgA:undetectable | 1xdkB-3tzgA:20.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vay | HAD-SUPERFAMILYHYDROLASE (Pseudomonassyringae groupgenomosp. 3) |
PF13419(HAD_2) | 5 | ALA A 90LEU A 38LEU A 76LEU A 46LEU A 31 | None | 1.21A | 1xdkB-3vayA:undetectable | 1xdkB-3vayA:22.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4df9 | PUTATIVE PEPTIDASE (Bacteroidesfragilis) |
PF09471(Peptidase_M64)PF16217(M64_N) | 5 | PHE A 193ALA A 221LEU A 269ILE A 277ILE A 278 | None | 1.04A | 1xdkB-4df9A:undetectable | 1xdkB-4df9A:19.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dq1 | THYMIDYLATE SYNTHASE (Staphylococcusaureus) |
PF00303(Thymidylat_synt) | 5 | LEU A 239LEU A 242ILE A 243LEU A 167LEU A 64 | None | 0.91A | 1xdkB-4dq1A:undetectable | 1xdkB-4dq1A:18.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dq1 | THYMIDYLATE SYNTHASE (Staphylococcusaureus) |
PF00303(Thymidylat_synt) | 5 | LEU A 239LEU A 242ILE A 243SER A 289LEU A 167 | None | 1.15A | 1xdkB-4dq1A:undetectable | 1xdkB-4dq1A:18.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g34 | EUKARYOTICTRANSLATIONINITIATION FACTOR2-ALPHA KINASE 3 (Homo sapiens) |
PF00069(Pkinase) | 5 | ALA A 923LEU A1009ILE A1070ILE A1071LEU A 937 | None | 1.09A | 1xdkB-4g34A:undetectable | 1xdkB-4g34A:22.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gq2 | NUCLEOPORIN NUP120 (Schizosaccharomycespombe) |
PF11715(Nup160) | 5 | LEU M 652ILE M 649ILE M 653SER M 658LEU M 698 | None | 1.07A | 1xdkB-4gq2M:undetectable | 1xdkB-4gq2M:16.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gx8 | DNA POLYMERASE IIISUBUNIT EPSILON,DNAPOLYMERASE IIISUBUNIT ALPHA (Escherichiacoli) |
PF02811(PHP) | 5 | LEU A 142LEU A 145ILE A 146ARG A 152LEU A 173 | None | 0.92A | 1xdkB-4gx8A:undetectable | 1xdkB-4gx8A:22.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hz8 | BETA-GLUCOSIDASE (unculturedbacterium) |
PF00232(Glyco_hydro_1) | 5 | LEU A 289LEU A 292ILE A 293LEU A 381LEU A 259 | None | 0.93A | 1xdkB-4hz8A:undetectable | 1xdkB-4hz8A:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4isa | UDP-3-O-[3-HYDROXYMYRISTOYL]N-ACETYLGLUCOSAMINEDEACETYLASE (Escherichiacoli) |
PF03331(LpxC) | 5 | ALA A 52LEU A 80ILE A 101ILE A 74LEU A 84 | None | 1.03A | 1xdkB-4isaA:undetectable | 1xdkB-4isaA:22.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m7e | PROTEINBRASSINOSTEROIDINSENSITIVE 1 (Arabidopsisthaliana) |
PF00560(LRR_1)PF08263(LRRNT_2)PF12799(LRR_4)PF13516(LRR_6)PF13855(LRR_8) | 5 | LEU A 556ILE A 552ILE A 576LEU A 567LEU A 562 | None | 1.01A | 1xdkB-4m7eA:undetectable | 1xdkB-4m7eA:16.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mt1 | DRUG EFFLUX PROTEIN (Neisseriagonorrhoeae) |
PF00873(ACR_tran) | 5 | ALA A 795LEU A 798ILE A 743ILE A 738SER A 792 | None | 1.15A | 1xdkB-4mt1A:undetectable | 1xdkB-4mt1A:14.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nbo | STEROID RECEPTOR RNAACTIVATOR 1 (Homo sapiens) |
PF07304(SRA1) | 5 | CYH A 125LEU A 201ILE A 202LEU A 164LEU A 141 | None | 1.25A | 1xdkB-4nboA:undetectable | 1xdkB-4nboA:16.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nmn | REPLICATIVE DNAHELICASE (Aquifexaeolicus) |
PF00772(DnaB)PF03796(DnaB_C) | 5 | LEU A 189ILE A 413ILE A 412ARG A 369LEU A 387 | None | 1.07A | 1xdkB-4nmnA:undetectable | 1xdkB-4nmnA:23.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4okq | HUT OPERON POSITIVEREGULATORY PROTEIN (Geobacillusthermodenitrificans) |
PF09021(HutP) | 5 | ALA A 106LEU A 144ILE A 146ILE A 122LEU A 14 | None | 1.13A | 1xdkB-4okqA:undetectable | 1xdkB-4okqA:23.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q22 | GLYCOSIDE HYDROLASEFAMILY 18 (Serratiaproteamaculans) |
PF00704(Glyco_hydro_18) | 5 | LEU A 271LEU A 219SER A 200LEU A 235LEU A 389 | None | 1.04A | 1xdkB-4q22A:undetectable | 1xdkB-4q22A:21.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rvw | ZNUD (Neisseriameningitidis) |
PF00593(TonB_dep_Rec)PF07715(Plug) | 5 | ALA A 135LEU A 42ILE A 37ILE A 36LEU A 53 | None | 1.18A | 1xdkB-4rvwA:undetectable | 1xdkB-4rvwA:18.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u7l | LEUCINE-RICH REPEATSANDIMMUNOGLOBULIN-LIKEDOMAINS PROTEIN 1 (Homo sapiens) |
PF01463(LRRCT)PF13855(LRR_8) | 5 | ALA A 142LEU A 128ILE A 125LEU A 95LEU A 130 | None | 1.21A | 1xdkB-4u7lA:undetectable | 1xdkB-4u7lA:22.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uy6 | HISTIDINE-SPECIFICMETHYLTRANSFERASEEGTD (Mycolicibacteriumsmegmatis) |
PF10017(Methyltransf_33) | 5 | ALA A 76LEU A 190LEU A 318LEU A 66LEU A 156 | None | 1.01A | 1xdkB-4uy6A:undetectable | 1xdkB-4uy6A:22.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4v08 | UL26 (Suidalphaherpesvirus1) |
PF00716(Peptidase_S21) | 5 | LEU A 73ILE A 49ILE A 39LEU A 105LEU A 97 | None | 1.17A | 1xdkB-4v08A:undetectable | 1xdkB-4v08A:22.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wjg | HAPTOGLOBIN (Homo sapiens) |
no annotation | 5 | ALA C 173ILE C 188SER C 278LEU C 245LEU C 248 | None | 1.05A | 1xdkB-4wjgC:undetectable | 1xdkB-4wjgC:21.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wjg | HAPTOGLOBIN (Homo sapiens) |
no annotation | 5 | ALA C 173LEU C 187ILE C 188LEU C 245LEU C 248 | None | 1.15A | 1xdkB-4wjgC:undetectable | 1xdkB-4wjgC:21.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xh9 | NEUROEPITHELIALCELL-TRANSFORMINGGENE 1 PROTEIN (Homo sapiens) |
PF00169(PH)PF00621(RhoGEF) | 5 | CYH A 495LEU A 410LEU A 405ILE A 403LEU A 436 | None | 1.23A | 1xdkB-4xh9A:undetectable | 1xdkB-4xh9A:26.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z0c | TOLL-LIKE RECEPTOR13 (Mus musculus) |
PF00560(LRR_1)PF13516(LRR_6)PF13855(LRR_8) | 5 | PHE A 589LEU A 626ILE A 607ILE A 576PHE A 614 | None | 0.89A | 1xdkB-4z0cA:undetectable | 1xdkB-4z0cA:17.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e7g | IPT/TIGDOMAIN-CONTAININGPROTEIN BACOVA_02650 (Bacteroidesovatus) |
no annotation | 5 | PHE A 160LEU A 212ILE A 141ILE A 156LEU A 200 | None | 1.07A | 1xdkB-5e7gA:undetectable | 1xdkB-5e7gA:20.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fku | DNA POLYMERASE IIISUBUNIT ALPHA (Escherichiacoli) |
PF01336(tRNA_anti-codon)PF02811(PHP)PF07733(DNA_pol3_alpha)PF14579(HHH_6) | 5 | LEU A 97LEU A 100ILE A 101ARG A 107LEU A 128 | None | 0.90A | 1xdkB-5fkuA:undetectable | 1xdkB-5fkuA:12.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g5p | NUCLEAR MRNA EXPORTPROTEIN SAC3 (Saccharomycescerevisiae) |
PF03399(SAC3_GANP) | 5 | LEU A 508ILE A 498ILE A 500PHE A 474LEU A 477 | None | 1.22A | 1xdkB-5g5pA:undetectable | 1xdkB-5g5pA:17.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hdh | TOLL-LIKE RECEPTOR 8 (Homo sapiens) |
PF13855(LRR_8) | 5 | PHE A 242LEU A 294ILE A 276ILE A 234LEU A 292 | None | 1.08A | 1xdkB-5hdhA:undetectable | 1xdkB-5hdhA:16.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i2g | DIOL DEHYDRATASE (Roseburiainulinivorans) |
PF01228(Gly_radical)PF02901(PFL-like) | 5 | LEU A 315ILE A 316ILE A 319LEU A 363LEU A 307 | None | 0.91A | 1xdkB-5i2gA:1.4 | 1xdkB-5i2gA:17.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j7w | THYMIDYLATE SYNTHASE (Enterococcusfaecalis) |
PF00303(Thymidylat_synt) | 5 | LEU A 235LEU A 238ILE A 239LEU A 163LEU A 60 | None | 0.96A | 1xdkB-5j7wA:undetectable | 1xdkB-5j7wA:22.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5k13 | RETINOIC ACIDRECEPTOR ALPHA (Homo sapiens) |
PF00104(Hormone_recep) | 7 | PHE A 228CYH A 235LEU A 266LEU A 269ILE A 270ARG A 276PHE A 302 | 6Q7 A 501 (-3.9A)6Q7 A 501 ( 3.7A)6Q7 A 501 (-4.2A)6Q7 A 501 (-3.7A)6Q7 A 501 (-4.8A)6Q7 A 501 (-3.2A)6Q7 A 501 ( 4.3A) | 0.68A | 1xdkB-5k13A:35.3 | 1xdkB-5k13A:78.18 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5k13 | RETINOIC ACIDRECEPTOR ALPHA (Homo sapiens) |
PF00104(Hormone_recep) | 7 | PHE A 228CYH A 235LEU A 266LEU A 269ILE A 270SER A 287PHE A 302 | 6Q7 A 501 (-3.9A)6Q7 A 501 ( 3.7A)6Q7 A 501 (-4.2A)6Q7 A 501 (-3.7A)6Q7 A 501 (-4.8A)6Q7 A 501 (-2.9A)6Q7 A 501 ( 4.3A) | 0.80A | 1xdkB-5k13A:35.3 | 1xdkB-5k13A:78.18 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5k13 | RETINOIC ACIDRECEPTOR ALPHA (Homo sapiens) |
PF00104(Hormone_recep) | 7 | PHE A 228CYH A 235LEU A 269ILE A 270ILE A 273ARG A 276PHE A 302 | 6Q7 A 501 (-3.9A)6Q7 A 501 ( 3.7A)6Q7 A 501 (-3.7A)6Q7 A 501 (-4.8A)6Q7 A 501 ( 3.9A)6Q7 A 501 (-3.2A)6Q7 A 501 ( 4.3A) | 0.60A | 1xdkB-5k13A:35.3 | 1xdkB-5k13A:78.18 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5k13 | RETINOIC ACIDRECEPTOR ALPHA (Homo sapiens) |
PF00104(Hormone_recep) | 7 | PHE A 228CYH A 235LEU A 269ILE A 270ILE A 273SER A 287PHE A 302 | 6Q7 A 501 (-3.9A)6Q7 A 501 ( 3.7A)6Q7 A 501 (-3.7A)6Q7 A 501 (-4.8A)6Q7 A 501 ( 3.9A)6Q7 A 501 (-2.9A)6Q7 A 501 ( 4.3A) | 0.71A | 1xdkB-5k13A:35.3 | 1xdkB-5k13A:78.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l3t | NUCLEAR MRNA EXPORTPROTEIN SAC3 (Saccharomycescerevisiae) |
PF03399(SAC3_GANP) | 5 | LEU A 508ILE A 498ILE A 500PHE A 474LEU A 477 | None | 1.22A | 1xdkB-5l3tA:undetectable | 1xdkB-5l3tA:14.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n5z | RNA POLYMERASEI-SPECIFICTRANSCRIPTIONINITIATION FACTORRRN3 (Saccharomycescerevisiae) |
PF05327(RRN3) | 5 | ALA O 476LEU O 446ARG O 452PHE O 505LEU O 502 | None | 1.25A | 1xdkB-5n5zO:undetectable | 1xdkB-5n5zO:17.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nij | VACUOLAR-PROCESSINGENZYME GAMMA-ISOZYME (Arabidopsisthaliana) |
no annotation | 5 | PHE A 225LEU A 191LEU A 183SER A 241PHE A 214 | None | 1.17A | 1xdkB-5nijA:undetectable | 1xdkB-5nijA:13.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5npy | FLAGELLAR BASAL BODYPROTEIN (Helicobacterpylori) |
no annotation | 5 | LEU A 310ILE A 352SER A 382PHE A 212LEU A 294 | None | 1.00A | 1xdkB-5npyA:undetectable | 1xdkB-5npyA:19.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nqd | ARSENITE OXIDASELARGE SUBUNIT AIOA[3FE-4S] CLUSTER,MO-MOLYBDOPTERINCOFACTOR-BINDINGACTIVE SITE (Rhizobium sp.NT-26) |
no annotation | 5 | LEU A 303ILE A 278PHE A 314LEU A 317LEU A 383 | None | 1.13A | 1xdkB-5nqdA:undetectable | 1xdkB-5nqdA:11.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5obt | VACUOLAR-PROCESSINGENZYME GAMMA-ISOZYME (Arabidopsisthaliana) |
no annotation | 5 | PHE A 225LEU A 191LEU A 183SER A 241PHE A 214 | None | 1.11A | 1xdkB-5obtA:undetectable | 1xdkB-5obtA:12.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oqd | POLYCOMB PROTEIN PCL (Drosophilamelanogaster) |
no annotation | 5 | LEU B 585ILE B 603ILE B 607LEU B 636LEU B 658 | None | 1.15A | 1xdkB-5oqdB:undetectable | 1xdkB-5oqdB:21.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u1s | SEPARIN (Saccharomycescerevisiae) |
PF03568(Peptidase_C50) | 5 | LEU A1344ILE A1345SER A 998PHE A1296LEU A1330 | None | 0.85A | 1xdkB-5u1sA:undetectable | 1xdkB-5u1sA:11.62 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5uan | RETINOIC ACIDRECEPTOR BETA (Homo sapiens) |
no annotation | 12 | PHE B 221ALA B 225CYH B 228LEU B 259LEU B 262ILE B 263ILE B 266ARG B 269SER B 280PHE B 295LEU B 298LEU B 407 | REA B 503 ( 4.8A)REA B 503 (-3.8A)REA B 503 (-3.1A)NoneREA B 503 (-3.9A)REA B 503 (-4.4A)REA B 503 (-3.6A)REA B 503 ( 4.8A)REA B 503 (-2.1A)REA B 503 ( 4.0A)NoneNone | 0.44A | 1xdkB-5uanB:38.3 | 1xdkB-5uanB:98.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ubp | LEUCINE PERMEASETRANSCRIPTIONALREGULATOR (Saccharomycescerevisiae) |
PF03399(SAC3_GANP) | 5 | LEU A 508ILE A 498ILE A 500PHE A 474LEU A 477 | None | 1.22A | 1xdkB-5ubpA:undetectable | 1xdkB-5ubpA:21.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ui5 | RNA POLYMERASE SIGMAFACTOR RPON (Aquifexaeolicus) |
PF04552(Sigma54_DBD)PF04963(Sigma54_CBD) | 5 | LEU I 343LEU I 346ILE I 347ILE I 350LEU I 338 | None | 0.64A | 1xdkB-5ui5I:undetectable | 1xdkB-5ui5I:22.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uib | OXIDOREDUCTASEPROTEIN (Agrobacteriumtumefaciens) |
PF01408(GFO_IDH_MocA) | 5 | ALA A 187LEU A 197LEU A 218ILE A 227LEU A 325 | None | 1.21A | 1xdkB-5uibA:undetectable | 1xdkB-5uibA:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xsy | SODIUM CHANNELPROTEIN (Electrophoruselectricus) |
PF00520(Ion_trans)PF06512(Na_trans_assoc) | 5 | ALA A1108LEU A1457LEU A1460ILE A1461ILE A1464 | None | 0.98A | 1xdkB-5xsyA:undetectable | 1xdkB-5xsyA:9.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xyh | CBSA (Xanthomonasoryzae) |
no annotation | 5 | LEU A 122ILE A 173ILE A 217LEU A 105LEU A 83 | None | 0.97A | 1xdkB-5xyhA:undetectable | 1xdkB-5xyhA:12.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bb9 | 4-AMINO-4-DEOXYCHORISMATE LYASE (Salmonellaenterica) |
no annotation | 5 | ILE A 234ILE A 242ARG A 117SER A 114LEU A 123 | None | 1.15A | 1xdkB-6bb9A:undetectable | 1xdkB-6bb9A:19.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c90 | EXOSOME RNA HELICASEMTR4,EXOSOME RNAHELICASE MTR4 (Homo sapiens) |
no annotation | 5 | LEU A 236LEU A 232ILE A 231SER A 195LEU A 273 | None | 1.25A | 1xdkB-6c90A:undetectable | 1xdkB-6c90A:14.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cfw | MBH SUBUNITMONOVALENT CATION/H+ANTIPORTER SUBUNIT F (Pyrococcusfuriosus) |
no annotation | 5 | ALA B 13LEU B 37LEU B 40ILE B 41LEU D 52 | None | 1.12A | 1xdkB-6cfwB:undetectable | 1xdkB-6cfwB:12.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cfw | MBH SUBUNITMONOVALENT CATION/H+ANTIPORTER SUBUNIT F (Pyrococcusfuriosus) |
no annotation | 5 | ALA B 13LEU B 37LEU B 40ILE B 44LEU D 52 | None | 1.10A | 1xdkB-6cfwB:undetectable | 1xdkB-6cfwB:12.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ehs | HYDROGENASE-2 LARGECHAIN (Escherichiacoli) |
no annotation | 5 | ALA L 97LEU L 208ILE L 243ILE L 247LEU L 446 | None | 0.79A | 1xdkB-6ehsL:undetectable | 1xdkB-6ehsL:11.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fx0 | RETINOIC ACIDRECEPTOR GAMMA (Homo sapiens) |
no annotation | 9 | PHE A 230ALA A 234CYH A 237LEU A 268LEU A 271ILE A 275ARG A 278SER A 289PHE A 304 | E9T A 501 (-4.3A)E9T A 501 (-3.7A)E9T A 501 (-3.6A)E9T A 501 (-4.9A)E9T A 501 (-3.6A)E9T A 501 (-3.8A)E9T A 501 (-3.1A)E9T A 501 (-2.6A)E9T A 501 (-4.2A) | 0.56A | 1xdkB-6fx0A:37.1 | 1xdkB-6fx0A:15.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fx0 | RETINOIC ACIDRECEPTOR GAMMA (Homo sapiens) |
no annotation | 9 | PHE A 230ALA A 234CYH A 237LEU A 271ILE A 275ARG A 278SER A 289PHE A 304LEU A 307 | E9T A 501 (-4.3A)E9T A 501 (-3.7A)E9T A 501 (-3.6A)E9T A 501 (-3.6A)E9T A 501 (-3.8A)E9T A 501 (-3.1A)E9T A 501 (-2.6A)E9T A 501 (-4.2A)None | 0.62A | 1xdkB-6fx0A:37.1 | 1xdkB-6fx0A:15.51 |