SIMILAR PATTERNS OF AMINO ACIDS FOR 1XDK_B_9CRB600

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dnp DNA PHOTOLYASE

(Escherichia
coli) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		5 LEU A 272
LEU A 275
ILE A 276
LEU A 158
LEU A 255
 None
FAD  A 472 ( 4.7A)
None
None
None
 1.26A 1xdkB-1dnpA:
0.0		 1xdkB-1dnpA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1k ADRENODOXIN
REDUCTASE

(Bos taurus) 		PF07992
(Pyr_redox_2) 		5 LEU A 210
ILE A 194
SER A 328
LEU A 223
LEU A 245
 None
None
NAP  A 802 (-4.1A)
None
None
 0.97A 1xdkB-1e1kA:
undetectable		 1xdkB-1e1kA:
21.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1exx RETINOIC ACID
RECEPTOR GAMMA-2

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 PHE A 230
ALA A 234
CYH A 237
LEU A 268
LEU A 271
ILE A 275
ARG A 278
SER A 289
PHE A 304
 961  A 450 (-3.9A)
961  A 450 (-3.1A)
961  A 450 (-3.6A)
961  A 450 ( 4.9A)
961  A 450 (-3.6A)
961  A 450 (-3.5A)
961  A 450 (-3.6A)
961  A 450 (-2.5A)
961  A 450 (-3.6A)
 0.54A 1xdkB-1exxA:
37.3		 1xdkB-1exxA:
81.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1exx RETINOIC ACID
RECEPTOR GAMMA-2

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 PHE A 230
ALA A 234
CYH A 237
PHE A 304
LEU A 268
 961  A 450 (-3.9A)
961  A 450 (-3.1A)
961  A 450 (-3.6A)
961  A 450 (-3.6A)
961  A 450 ( 4.9A)
 1.13A 1xdkB-1exxA:
37.3		 1xdkB-1exxA:
81.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1exx RETINOIC ACID
RECEPTOR GAMMA-2

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 PHE A 230
ALA A 234
ILE A 275
ARG A 278
SER A 289
PHE A 304
LEU A 307
 961  A 450 (-3.9A)
961  A 450 (-3.1A)
961  A 450 (-3.5A)
961  A 450 (-3.6A)
961  A 450 (-2.5A)
961  A 450 (-3.6A)
961  A 450 (-4.8A)
 0.55A 1xdkB-1exxA:
37.3		 1xdkB-1exxA:
81.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1exx RETINOIC ACID
RECEPTOR GAMMA-2

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 PHE A 230
ALA A 234
PHE A 304
LEU A 307
LEU A 268
 961  A 450 (-3.9A)
961  A 450 (-3.1A)
961  A 450 (-3.6A)
961  A 450 (-4.8A)
961  A 450 ( 4.9A)
 1.02A 1xdkB-1exxA:
37.3		 1xdkB-1exxA:
81.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH

(Escherichia
coli) 		PF00588
(SpoU_methylase)
PF08032
(SpoU_sub_bind) 		5 ALA A  72
LEU A  39
ILE A   8
SER A  62
LEU A  43
 None
 0.86A 1xdkB-1gz0A:
undetectable		 1xdkB-1gz0A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1seh DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDOHYDROLASE

(Escherichia
coli) 		PF00692
(dUTPase) 		5 LEU A  97
ILE A  89
ILE A  59
PHE A 122
LEU A  55
 UMP  A 777 (-4.7A)
UMP  A 777 (-3.9A)
None
None
None
 1.22A 1xdkB-1sehA:
undetectable		 1xdkB-1sehA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 41 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF08542
(Rep_fac_C) 		5 PHE D 189
ALA D  45
LEU D  36
LEU D  49
SER D 185
 None
 1.26A 1xdkB-1sxjD:
undetectable		 1xdkB-1sxjD:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t90 PROBABLE
METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00171
(Aldedh) 		5 PHE A 163
LEU A  86
PHE A  75
LEU A 191
LEU A 184
 None
 1.11A 1xdkB-1t90A:
undetectable		 1xdkB-1t90A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukf AVIRULENCE PROTEIN
AVRPPH3

(Pseudomonas
savastanoi) 		PF03543
(Peptidase_C58) 		5 LEU A 225
ILE A 244
ILE A 248
SER A 253
LEU A 202
 None
 0.90A 1xdkB-1ukfA:
0.0		 1xdkB-1ukfA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1upr PLECKSTRIN HOMOLOGY
DOMAIN-CONTAINING
FAMILY A MEMBER 4

(Homo sapiens) 		PF00169
(PH) 		5 ALA A1147
LEU A1084
LEU A1079
LEU A1133
LEU A1101
 None
 1.16A 1xdkB-1uprA:
0.0		 1xdkB-1uprA:
16.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xap RETINOIC ACID
RECEPTOR BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 PHE A 221
ALA A 225
CYH A 228
LEU A 259
LEU A 262
ILE A 263
ILE A 266
ARG A 269
SER A 280
PHE A 295
 TTB  A   1 (-4.7A)
TTB  A   1 (-4.0A)
TTB  A   1 ( 3.8A)
TTB  A   1 ( 4.9A)
TTB  A   1 (-3.9A)
TTB  A   1 ( 4.9A)
TTB  A   1 ( 4.0A)
TTB  A   1 (-3.3A)
TTB  A   1 (-3.1A)
TTB  A   1 ( 4.1A)
 0.46A 1xdkB-1xapA:
37.1		 1xdkB-1xapA:
92.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8t HYPOTHETICAL PROTEIN
RV0983

(Mycobacterium
tuberculosis) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 ALA A 217
LEU A  38
ILE A  37
ILE A  44
LEU A 105
 None
 1.24A 1xdkB-1y8tA:
undetectable		 1xdkB-1y8tA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9q TRANSCRIPTIONAL
REGULATOR, HTH_3
FAMILY

(Vibrio cholerae) 		PF01381
(HTH_3) 		5 LEU A  19
LEU A  16
ILE A  12
SER A  49
LEU A  63
 None
 1.04A 1xdkB-1y9qA:
undetectable		 1xdkB-1y9qA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy2 TRANSCRIPTIONAL
REGULATOR NTRC1

(Aquifex
aeolicus) 		PF00072
(Response_reg) 		5 ALA A  90
LEU A  50
LEU A  63
ILE A  62
LEU A  54
 None
PHD  A  51 ( 3.8A)
None
None
PHD  A  51 ( 4.3A)
 1.17A 1xdkB-1zy2A:
undetectable		 1xdkB-1zy2A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a6c HELIX-TURN-HELIX
MOTIF

(Nitrosomonas
europaea) 		PF13744
(HTH_37) 		5 LEU A  11
LEU A  52
ILE A  56
ILE A  53
LEU A  39
 None
 1.03A 1xdkB-2a6cA:
undetectable		 1xdkB-2a6cA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hmf PROBABLE
ASPARTOKINASE

(Methanocaldococcus
jannaschii) 		PF00696
(AA_kinase)
PF01842
(ACT)
PF13840
(ACT_7) 		5 PHE A  68
ALA A  48
LEU A 132
ILE A 125
ARG A 122
 None
 1.00A 1xdkB-2hmfA:
undetectable		 1xdkB-2hmfA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnh DNA POLYMERASE III
ALPHA SUBUNIT

(Escherichia
coli) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		5 LEU A  97
LEU A 100
ILE A 101
ARG A 107
LEU A 128
 None
 0.93A 1xdkB-2hnhA:
undetectable		 1xdkB-2hnhA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5c PLECKSTRIN

(Homo sapiens) 		PF00169
(PH) 		5 ALA A 341
LEU A 275
LEU A 268
LEU A 327
LEU A 292
 None
 1.18A 1xdkB-2i5cA:
undetectable		 1xdkB-2i5cA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oew PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN

(Homo sapiens) 		PF03097
(BRO1) 		5 PHE A  93
ILE A  78
ILE A  75
SER A 121
LEU A  21
 None
 1.10A 1xdkB-2oewA:
undetectable		 1xdkB-2oewA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1n TRANSPORT INHIBITOR
RESPONSE 1 PROTEIN

(Arabidopsis
thaliana) 		PF12937
(F-box-like) 		5 ALA B 152
LEU B 189
ILE B 191
LEU B 203
LEU B 186
 None
 0.99A 1xdkB-2p1nB:
undetectable		 1xdkB-2p1nB:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pb0 ACETYLORNITHINE/SUCC
INYLDIAMINOPIMELATE
AMINOTRANSFERASE

(Salmonella
enterica) 		PF00202
(Aminotran_3) 		5 PHE A 378
LEU A 346
ILE A 331
ILE A 325
PHE A 396
 None
 1.16A 1xdkB-2pb0A:
undetectable		 1xdkB-2pb0A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2plg TLL0839 PROTEIN

(Synechococcus
elongatus) 		PF10722
(YbjN) 		5 ALA A 119
LEU A 134
ILE A 131
ILE A 135
LEU A  65
 None
 1.03A 1xdkB-2plgA:
undetectable		 1xdkB-2plgA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w5f ENDO-1,4-BETA-XYLANA
SE Y

(Ruminiclostridium
thermocellum) 		PF00331
(Glyco_hydro_10)
PF02018
(CBM_4_9) 		5 PHE A 203
ALA A 486
ILE A 538
LEU A 195
LEU A 461
 None
 1.11A 1xdkB-2w5fA:
undetectable		 1xdkB-2w5fA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w9f CELL DIVISION
PROTEIN KINASE 4

(Homo sapiens) 		PF00069
(Pkinase) 		5 CYH B 202
LEU B 273
LEU B 276
ILE B 230
ILE B 226
 None
 1.14A 1xdkB-2w9fB:
undetectable		 1xdkB-2w9fB:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wvl MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE

(Thermus
thermophilus) 		PF09488
(Osmo_MPGsynth) 		5 ALA A 155
LEU A 369
LEU A 152
ILE A 149
LEU A 125
 None
 1.25A 1xdkB-2wvlA:
undetectable		 1xdkB-2wvlA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahm OLIGOPEPTIDASE

(Geobacillus sp.
MO-1) 		no annotation 5 PHE A 498
ALA A 417
LEU A 251
ILE A 247
ILE A 244
 None
 1.22A 1xdkB-3ahmA:
undetectable		 1xdkB-3ahmA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwx ALPHA/BETA HYDROLASE

(Novosphingobium
aromaticivorans) 		PF12697
(Abhydrolase_6) 		5 ALA A 116
ILE A 121
PHE A  98
LEU A  32
LEU A  83
 None
 1.13A 1xdkB-3bwxA:
undetectable		 1xdkB-3bwxA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7n NUCLEOPORIN NUP120

(Saccharomyces
cerevisiae) 		PF11715
(Nup160) 		5 LEU A 574
ILE A 579
PHE A 637
LEU A 642
LEU A 570
 None
 0.98A 1xdkB-3h7nA:
undetectable		 1xdkB-3h7nA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i7f ASPARTYL-TRNA
SYNTHETASE

(Entamoeba
histolytica) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		5 LEU A 419
LEU A 422
ILE A 423
LEU A 389
LEU A 398
 None
 1.04A 1xdkB-3i7fA:
undetectable		 1xdkB-3i7fA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihu TRANSCRIPTIONAL
REGULATOR, GNTR
FAMILY

(Cupriavidus
pinatubonensis) 		PF00392
(GntR)
PF07729
(FCD) 		5 ALA A  58
LEU A  39
ILE A  78
ILE A  67
LEU A  44
 None
 0.85A 1xdkB-3ihuA:
undetectable		 1xdkB-3ihuA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jvv TWITCHING MOBILITY
PROTEIN

(Pseudomonas
aeruginosa) 		PF00437
(T2SSE) 		5 LEU A  50
ILE A  51
ILE A  54
PHE A  96
LEU A  42
 None
 0.88A 1xdkB-3jvvA:
undetectable		 1xdkB-3jvvA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 824
LEU A 852
ILE A 849
ILE A 853
LEU A 877
 None
 1.23A 1xdkB-3kbaA:
20.6		 1xdkB-3kbaA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll3 GLUCONATE KINASE

(Lactobacillus
acidophilus) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 LEU A 378
ILE A 374
ILE A 371
ARG A 368
LEU A 255
 None
 1.03A 1xdkB-3ll3A:
undetectable		 1xdkB-3ll3A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lov PROTOPORPHYRINOGEN
OXIDASE

(Exiguobacterium
sibiricum) 		PF01593
(Amino_oxidase) 		5 ALA A  17
LEU A  68
LEU A  71
ILE A  72
LEU A 234
 None
 0.91A 1xdkB-3lovA:
undetectable		 1xdkB-3lovA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lwj PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Syntrophomonas
wolfei) 		PF00440
(TetR_N) 		5 LEU A  62
LEU A  59
ILE A  58
SER A 116
LEU A 105
 None
 0.95A 1xdkB-3lwjA:
undetectable		 1xdkB-3lwjA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o82 PEPTIDE ARYLATION
ENZYME

(Acinetobacter
baumannii) 		PF00501
(AMP-binding) 		5 LEU A 128
ILE A 130
ARG A 133
LEU A  66
LEU A  75
 None
 1.12A 1xdkB-3o82A:
undetectable		 1xdkB-3o82A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4

(Saccharomyces
cerevisiae) 		PF11701
(UNC45-central) 		5 LEU A 693
ILE A 694
ILE A 698
PHE A 718
LEU A 721
 None
 0.72A 1xdkB-3opbA:
undetectable		 1xdkB-3opbA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdi NITROGENASE MOFE
COFACTOR
BIOSYNTHESIS PROTEIN
NIFN

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro) 		5 ALA B 280
LEU B 268
ILE B 188
ILE B 192
SER B 285
 None
 1.24A 1xdkB-3pdiB:
undetectable		 1xdkB-3pdiB:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pih UVRABC SYSTEM
PROTEIN A

(Thermotoga
maritima) 		PF00005
(ABC_tran) 		5 LEU A 139
LEU A 136
ILE A 135
ILE A 132
LEU A 210
 None
 0.69A 1xdkB-3pihA:
undetectable		 1xdkB-3pihA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		5 ALA B 922
LEU B1008
ILE B1069
ILE B1070
LEU B 936
 None
 1.20A 1xdkB-3qd2B:
undetectable		 1xdkB-3qd2B:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rre PUTATIVE
UNCHARACTERIZED
PROTEIN

(Thermotoga
maritima) 		PF01256
(Carb_kinase)
PF03853
(YjeF_N) 		5 LEU A 477
LEU A 480
ILE A 481
ARG A 486
LEU A 472
 None
 0.82A 1xdkB-3rreA:
undetectable		 1xdkB-3rreA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr8 OLIGORIBONUCLEASE

(Coxiella
burnetii) 		PF00929
(RNase_T) 		5 ALA A  45
LEU A  71
ILE A  26
ILE A  48
LEU A 159
 None
 1.11A 1xdkB-3tr8A:
undetectable		 1xdkB-3tr8A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tzg HYPOTHETICAL PROTEIN
BVU_2266

(Bacteroides
vulgatus) 		no annotation 5 LEU A  47
ILE A  55
ARG A  64
PHE A 206
LEU A 209
 None
 0.99A 1xdkB-3tzgA:
undetectable		 1xdkB-3tzgA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vay HAD-SUPERFAMILY
HYDROLASE

(Pseudomonas
syringae group
genomosp. 3) 		PF13419
(HAD_2) 		5 ALA A  90
LEU A  38
LEU A  76
LEU A  46
LEU A  31
 None
 1.21A 1xdkB-3vayA:
undetectable		 1xdkB-3vayA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4df9 PUTATIVE PEPTIDASE

(Bacteroides
fragilis) 		PF09471
(Peptidase_M64)
PF16217
(M64_N) 		5 PHE A 193
ALA A 221
LEU A 269
ILE A 277
ILE A 278
 None
 1.04A 1xdkB-4df9A:
undetectable		 1xdkB-4df9A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dq1 THYMIDYLATE SYNTHASE

(Staphylococcus
aureus) 		PF00303
(Thymidylat_synt) 		5 LEU A 239
LEU A 242
ILE A 243
LEU A 167
LEU A  64
 None
 0.91A 1xdkB-4dq1A:
undetectable		 1xdkB-4dq1A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dq1 THYMIDYLATE SYNTHASE

(Staphylococcus
aureus) 		PF00303
(Thymidylat_synt) 		5 LEU A 239
LEU A 242
ILE A 243
SER A 289
LEU A 167
 None
 1.15A 1xdkB-4dq1A:
undetectable		 1xdkB-4dq1A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 923
LEU A1009
ILE A1070
ILE A1071
LEU A 937
 None
 1.09A 1xdkB-4g34A:
undetectable		 1xdkB-4g34A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gq2 NUCLEOPORIN NUP120

(Schizosaccharomyces
pombe) 		PF11715
(Nup160) 		5 LEU M 652
ILE M 649
ILE M 653
SER M 658
LEU M 698
 None
 1.07A 1xdkB-4gq2M:
undetectable		 1xdkB-4gq2M:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gx8 DNA POLYMERASE III
SUBUNIT EPSILON,DNA
POLYMERASE III
SUBUNIT ALPHA

(Escherichia
coli) 		PF02811
(PHP) 		5 LEU A 142
LEU A 145
ILE A 146
ARG A 152
LEU A 173
 None
 0.92A 1xdkB-4gx8A:
undetectable		 1xdkB-4gx8A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hz8 BETA-GLUCOSIDASE

(uncultured
bacterium) 		PF00232
(Glyco_hydro_1) 		5 LEU A 289
LEU A 292
ILE A 293
LEU A 381
LEU A 259
 None
 0.93A 1xdkB-4hz8A:
undetectable		 1xdkB-4hz8A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4isa UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE

(Escherichia
coli) 		PF03331
(LpxC) 		5 ALA A  52
LEU A  80
ILE A 101
ILE A  74
LEU A  84
 None
 1.03A 1xdkB-4isaA:
undetectable		 1xdkB-4isaA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 556
ILE A 552
ILE A 576
LEU A 567
LEU A 562
 None
 1.01A 1xdkB-4m7eA:
undetectable		 1xdkB-4m7eA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mt1 DRUG EFFLUX PROTEIN

(Neisseria
gonorrhoeae) 		PF00873
(ACR_tran) 		5 ALA A 795
LEU A 798
ILE A 743
ILE A 738
SER A 792
 None
 1.15A 1xdkB-4mt1A:
undetectable		 1xdkB-4mt1A:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbo STEROID RECEPTOR RNA
ACTIVATOR 1

(Homo sapiens) 		PF07304
(SRA1) 		5 CYH A 125
LEU A 201
ILE A 202
LEU A 164
LEU A 141
 None
 1.25A 1xdkB-4nboA:
undetectable		 1xdkB-4nboA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nmn REPLICATIVE DNA
HELICASE

(Aquifex
aeolicus) 		PF00772
(DnaB)
PF03796
(DnaB_C) 		5 LEU A 189
ILE A 413
ILE A 412
ARG A 369
LEU A 387
 None
 1.07A 1xdkB-4nmnA:
undetectable		 1xdkB-4nmnA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4okq HUT OPERON POSITIVE
REGULATORY PROTEIN

(Geobacillus
thermodenitrificans) 		PF09021
(HutP) 		5 ALA A 106
LEU A 144
ILE A 146
ILE A 122
LEU A  14
 None
 1.13A 1xdkB-4okqA:
undetectable		 1xdkB-4okqA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q22 GLYCOSIDE HYDROLASE
FAMILY 18

(Serratia
proteamaculans) 		PF00704
(Glyco_hydro_18) 		5 LEU A 271
LEU A 219
SER A 200
LEU A 235
LEU A 389
 None
 1.04A 1xdkB-4q22A:
undetectable		 1xdkB-4q22A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvw ZNUD

(Neisseria
meningitidis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 ALA A 135
LEU A  42
ILE A  37
ILE A  36
LEU A  53
 None
 1.18A 1xdkB-4rvwA:
undetectable		 1xdkB-4rvwA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u7l LEUCINE-RICH REPEATS
AND
IMMUNOGLOBULIN-LIKE
DOMAINS PROTEIN 1

(Homo sapiens) 		PF01463
(LRRCT)
PF13855
(LRR_8) 		5 ALA A 142
LEU A 128
ILE A 125
LEU A  95
LEU A 130
 None
 1.21A 1xdkB-4u7lA:
undetectable		 1xdkB-4u7lA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uy6 HISTIDINE-SPECIFIC
METHYLTRANSFERASE
EGTD

(Mycolicibacterium
smegmatis) 		PF10017
(Methyltransf_33) 		5 ALA A  76
LEU A 190
LEU A 318
LEU A  66
LEU A 156
 None
 1.01A 1xdkB-4uy6A:
undetectable		 1xdkB-4uy6A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v08 UL26

(Suid
alphaherpesvirus
1) 		PF00716
(Peptidase_S21) 		5 LEU A  73
ILE A  49
ILE A  39
LEU A 105
LEU A  97
 None
 1.17A 1xdkB-4v08A:
undetectable		 1xdkB-4v08A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjg HAPTOGLOBIN

(Homo sapiens) 		no annotation 5 ALA C 173
ILE C 188
SER C 278
LEU C 245
LEU C 248
 None
 1.05A 1xdkB-4wjgC:
undetectable		 1xdkB-4wjgC:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjg HAPTOGLOBIN

(Homo sapiens) 		no annotation 5 ALA C 173
LEU C 187
ILE C 188
LEU C 245
LEU C 248
 None
 1.15A 1xdkB-4wjgC:
undetectable		 1xdkB-4wjgC:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xh9 NEUROEPITHELIAL
CELL-TRANSFORMING
GENE 1 PROTEIN

(Homo sapiens) 		PF00169
(PH)
PF00621
(RhoGEF) 		5 CYH A 495
LEU A 410
LEU A 405
ILE A 403
LEU A 436
 None
 1.23A 1xdkB-4xh9A:
undetectable		 1xdkB-4xh9A:
26.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0c TOLL-LIKE RECEPTOR
13

(Mus musculus) 		PF00560
(LRR_1)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 PHE A 589
LEU A 626
ILE A 607
ILE A 576
PHE A 614
 None
 0.89A 1xdkB-4z0cA:
undetectable		 1xdkB-4z0cA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7g IPT/TIG
DOMAIN-CONTAINING
PROTEIN BACOVA_02650

(Bacteroides
ovatus) 		no annotation 5 PHE A 160
LEU A 212
ILE A 141
ILE A 156
LEU A 200
 None
 1.07A 1xdkB-5e7gA:
undetectable		 1xdkB-5e7gA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fku DNA POLYMERASE III
SUBUNIT ALPHA

(Escherichia
coli) 		PF01336
(tRNA_anti-codon)
PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		5 LEU A  97
LEU A 100
ILE A 101
ARG A 107
LEU A 128
 None
 0.90A 1xdkB-5fkuA:
undetectable		 1xdkB-5fkuA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5p NUCLEAR MRNA EXPORT
PROTEIN SAC3

(Saccharomyces
cerevisiae) 		PF03399
(SAC3_GANP) 		5 LEU A 508
ILE A 498
ILE A 500
PHE A 474
LEU A 477
 None
 1.22A 1xdkB-5g5pA:
undetectable		 1xdkB-5g5pA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdh TOLL-LIKE RECEPTOR 8

(Homo sapiens) 		PF13855
(LRR_8) 		5 PHE A 242
LEU A 294
ILE A 276
ILE A 234
LEU A 292
 None
 1.08A 1xdkB-5hdhA:
undetectable		 1xdkB-5hdhA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2g DIOL DEHYDRATASE

(Roseburia
inulinivorans) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		5 LEU A 315
ILE A 316
ILE A 319
LEU A 363
LEU A 307
 None
 0.91A 1xdkB-5i2gA:
1.4		 1xdkB-5i2gA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j7w THYMIDYLATE SYNTHASE

(Enterococcus
faecalis) 		PF00303
(Thymidylat_synt) 		5 LEU A 235
LEU A 238
ILE A 239
LEU A 163
LEU A  60
 None
 0.96A 1xdkB-5j7wA:
undetectable		 1xdkB-5j7wA:
22.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5k13 RETINOIC ACID
RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 PHE A 228
CYH A 235
LEU A 266
LEU A 269
ILE A 270
ARG A 276
PHE A 302
 6Q7  A 501 (-3.9A)
6Q7  A 501 ( 3.7A)
6Q7  A 501 (-4.2A)
6Q7  A 501 (-3.7A)
6Q7  A 501 (-4.8A)
6Q7  A 501 (-3.2A)
6Q7  A 501 ( 4.3A)
 0.68A 1xdkB-5k13A:
35.3		 1xdkB-5k13A:
78.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5k13 RETINOIC ACID
RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 PHE A 228
CYH A 235
LEU A 266
LEU A 269
ILE A 270
SER A 287
PHE A 302
 6Q7  A 501 (-3.9A)
6Q7  A 501 ( 3.7A)
6Q7  A 501 (-4.2A)
6Q7  A 501 (-3.7A)
6Q7  A 501 (-4.8A)
6Q7  A 501 (-2.9A)
6Q7  A 501 ( 4.3A)
 0.80A 1xdkB-5k13A:
35.3		 1xdkB-5k13A:
78.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5k13 RETINOIC ACID
RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 PHE A 228
CYH A 235
LEU A 269
ILE A 270
ILE A 273
ARG A 276
PHE A 302
 6Q7  A 501 (-3.9A)
6Q7  A 501 ( 3.7A)
6Q7  A 501 (-3.7A)
6Q7  A 501 (-4.8A)
6Q7  A 501 ( 3.9A)
6Q7  A 501 (-3.2A)
6Q7  A 501 ( 4.3A)
 0.60A 1xdkB-5k13A:
35.3		 1xdkB-5k13A:
78.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5k13 RETINOIC ACID
RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 PHE A 228
CYH A 235
LEU A 269
ILE A 270
ILE A 273
SER A 287
PHE A 302
 6Q7  A 501 (-3.9A)
6Q7  A 501 ( 3.7A)
6Q7  A 501 (-3.7A)
6Q7  A 501 (-4.8A)
6Q7  A 501 ( 3.9A)
6Q7  A 501 (-2.9A)
6Q7  A 501 ( 4.3A)
 0.71A 1xdkB-5k13A:
35.3		 1xdkB-5k13A:
78.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3t NUCLEAR MRNA EXPORT
PROTEIN SAC3

(Saccharomyces
cerevisiae) 		PF03399
(SAC3_GANP) 		5 LEU A 508
ILE A 498
ILE A 500
PHE A 474
LEU A 477
 None
 1.22A 1xdkB-5l3tA:
undetectable		 1xdkB-5l3tA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n5z RNA POLYMERASE
I-SPECIFIC
TRANSCRIPTION
INITIATION FACTOR
RRN3

(Saccharomyces
cerevisiae) 		PF05327
(RRN3) 		5 ALA O 476
LEU O 446
ARG O 452
PHE O 505
LEU O 502
 None
 1.25A 1xdkB-5n5zO:
undetectable		 1xdkB-5n5zO:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nij VACUOLAR-PROCESSING
ENZYME GAMMA-ISOZYME

(Arabidopsis
thaliana) 		no annotation 5 PHE A 225
LEU A 191
LEU A 183
SER A 241
PHE A 214
 None
 1.17A 1xdkB-5nijA:
undetectable		 1xdkB-5nijA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5npy FLAGELLAR BASAL BODY
PROTEIN

(Helicobacter
pylori) 		no annotation 5 LEU A 310
ILE A 352
SER A 382
PHE A 212
LEU A 294
 None
 1.00A 1xdkB-5npyA:
undetectable		 1xdkB-5npyA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqd ARSENITE OXIDASE
LARGE SUBUNIT AIOA
[3FE-4S] CLUSTER,
MO-MOLYBDOPTERIN
COFACTOR-BINDING
ACTIVE SITE

(Rhizobium sp.
NT-26) 		no annotation 5 LEU A 303
ILE A 278
PHE A 314
LEU A 317
LEU A 383
 None
 1.13A 1xdkB-5nqdA:
undetectable		 1xdkB-5nqdA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5obt VACUOLAR-PROCESSING
ENZYME GAMMA-ISOZYME

(Arabidopsis
thaliana) 		no annotation 5 PHE A 225
LEU A 191
LEU A 183
SER A 241
PHE A 214
 None
 1.11A 1xdkB-5obtA:
undetectable		 1xdkB-5obtA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oqd POLYCOMB PROTEIN PCL

(Drosophila
melanogaster) 		no annotation 5 LEU B 585
ILE B 603
ILE B 607
LEU B 636
LEU B 658
 None
 1.15A 1xdkB-5oqdB:
undetectable		 1xdkB-5oqdB:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1s SEPARIN

(Saccharomyces
cerevisiae) 		PF03568
(Peptidase_C50) 		5 LEU A1344
ILE A1345
SER A 998
PHE A1296
LEU A1330
 None
 0.85A 1xdkB-5u1sA:
undetectable		 1xdkB-5u1sA:
11.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uan RETINOIC ACID
RECEPTOR BETA

(Homo sapiens) 		no annotation 12 PHE B 221
ALA B 225
CYH B 228
LEU B 259
LEU B 262
ILE B 263
ILE B 266
ARG B 269
SER B 280
PHE B 295
LEU B 298
LEU B 407
 REA  B 503 ( 4.8A)
REA  B 503 (-3.8A)
REA  B 503 (-3.1A)
None
REA  B 503 (-3.9A)
REA  B 503 (-4.4A)
REA  B 503 (-3.6A)
REA  B 503 ( 4.8A)
REA  B 503 (-2.1A)
REA  B 503 ( 4.0A)
None
None
 0.44A 1xdkB-5uanB:
38.3		 1xdkB-5uanB:
98.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubp LEUCINE PERMEASE
TRANSCRIPTIONAL
REGULATOR

(Saccharomyces
cerevisiae) 		PF03399
(SAC3_GANP) 		5 LEU A 508
ILE A 498
ILE A 500
PHE A 474
LEU A 477
 None
 1.22A 1xdkB-5ubpA:
undetectable		 1xdkB-5ubpA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ui5 RNA POLYMERASE SIGMA
FACTOR RPON

(Aquifex
aeolicus) 		PF04552
(Sigma54_DBD)
PF04963
(Sigma54_CBD) 		5 LEU I 343
LEU I 346
ILE I 347
ILE I 350
LEU I 338
 None
 0.64A 1xdkB-5ui5I:
undetectable		 1xdkB-5ui5I:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uib OXIDOREDUCTASE
PROTEIN

(Agrobacterium
tumefaciens) 		PF01408
(GFO_IDH_MocA) 		5 ALA A 187
LEU A 197
LEU A 218
ILE A 227
LEU A 325
 None
 1.21A 1xdkB-5uibA:
undetectable		 1xdkB-5uibA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xsy SODIUM CHANNEL
PROTEIN

(Electrophorus
electricus) 		PF00520
(Ion_trans)
PF06512
(Na_trans_assoc) 		5 ALA A1108
LEU A1457
LEU A1460
ILE A1461
ILE A1464
 None
 0.98A 1xdkB-5xsyA:
undetectable		 1xdkB-5xsyA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyh CBSA

(Xanthomonas
oryzae) 		no annotation 5 LEU A 122
ILE A 173
ILE A 217
LEU A 105
LEU A  83
 None
 0.97A 1xdkB-5xyhA:
undetectable		 1xdkB-5xyhA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bb9 4-AMINO-4-DEOXYCHORI
SMATE LYASE

(Salmonella
enterica) 		no annotation 5 ILE A 234
ILE A 242
ARG A 117
SER A 114
LEU A 123
 None
 1.15A 1xdkB-6bb9A:
undetectable		 1xdkB-6bb9A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c90 EXOSOME RNA HELICASE
MTR4,EXOSOME RNA
HELICASE MTR4

(Homo sapiens) 		no annotation 5 LEU A 236
LEU A 232
ILE A 231
SER A 195
LEU A 273
 None
 1.25A 1xdkB-6c90A:
undetectable		 1xdkB-6c90A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F

(Pyrococcus
furiosus) 		no annotation 5 ALA B  13
LEU B  37
LEU B  40
ILE B  41
LEU D  52
 None
 1.12A 1xdkB-6cfwB:
undetectable		 1xdkB-6cfwB:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F

(Pyrococcus
furiosus) 		no annotation 5 ALA B  13
LEU B  37
LEU B  40
ILE B  44
LEU D  52
 None
 1.10A 1xdkB-6cfwB:
undetectable		 1xdkB-6cfwB:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ehs HYDROGENASE-2 LARGE
CHAIN

(Escherichia
coli) 		no annotation 5 ALA L  97
LEU L 208
ILE L 243
ILE L 247
LEU L 446
 None
 0.79A 1xdkB-6ehsL:
undetectable		 1xdkB-6ehsL:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fx0 RETINOIC ACID
RECEPTOR GAMMA

(Homo sapiens) 		no annotation 9 PHE A 230
ALA A 234
CYH A 237
LEU A 268
LEU A 271
ILE A 275
ARG A 278
SER A 289
PHE A 304
 E9T  A 501 (-4.3A)
E9T  A 501 (-3.7A)
E9T  A 501 (-3.6A)
E9T  A 501 (-4.9A)
E9T  A 501 (-3.6A)
E9T  A 501 (-3.8A)
E9T  A 501 (-3.1A)
E9T  A 501 (-2.6A)
E9T  A 501 (-4.2A)
 0.56A 1xdkB-6fx0A:
37.1		 1xdkB-6fx0A:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fx0 RETINOIC ACID
RECEPTOR GAMMA

(Homo sapiens) 		no annotation 9 PHE A 230
ALA A 234
CYH A 237
LEU A 271
ILE A 275
ARG A 278
SER A 289
PHE A 304
LEU A 307
 E9T  A 501 (-4.3A)
E9T  A 501 (-3.7A)
E9T  A 501 (-3.6A)
E9T  A 501 (-3.6A)
E9T  A 501 (-3.8A)
E9T  A 501 (-3.1A)
E9T  A 501 (-2.6A)
E9T  A 501 (-4.2A)
None
 0.62A 1xdkB-6fx0A:
37.1		 1xdkB-6fx0A:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aj8 CITRATE SYNTHASE

(Pyrococcus
furiosus) 		PF00285
(Citrate_synt) 		3 LEU A 317
PHE A 288
ARG A 273
 None
 0.74A 1xdkB-1aj8A:
0.0		 1xdkB-1aj8A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bs0 PROTEIN
(8-AMINO-7-OXONANOAT
E SYNTHASE)

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		3 LEU A 276
PHE A 234
ARG A 101
 None
 0.81A 1xdkB-1bs0A:
0.0		 1xdkB-1bs0A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6m DNA TOPOISOMERASE
III

(Escherichia
coli) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		3 LEU A 205
PHE A 506
ARG A 489
 None
 0.82A 1xdkB-1d6mA:
0.0		 1xdkB-1d6mA:
18.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1exx RETINOIC ACID
RECEPTOR GAMMA-2

(Homo sapiens) 		PF00104
(Hormone_recep) 		3 LEU A 233
PHE A 288
ARG A 396
 961  A 450 ( 4.0A)
961  A 450 (-4.6A)
None
 0.44A 1xdkB-1exxA:
37.3		 1xdkB-1exxA:
81.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f3b GLUTATHIONE
S-TRANSFERASE YA
CHAIN

(Mus musculus) 		PF00043
(GST_C)
PF02798
(GST_N) 		3 LEU A 159
PHE A 135
ARG A  68
 None
 0.85A 1xdkB-1f3bA:
0.0		 1xdkB-1f3bA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fiq XANTHINE OXIDASE

(Bos taurus) 		PF00111
(Fer2)
PF01799
(Fer2_2) 		3 LEU A   6
PHE A   8
ARG A  32
 None
 0.83A 1xdkB-1fiqA:
undetectable		 1xdkB-1fiqA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ftf ACYL CARRIER PROTEIN
SYNTHASE

(Streptococcus
pneumoniae) 		PF01648
(ACPS) 		3 LEU A1032
PHE A1040
ARG A1023
 None
 0.89A 1xdkB-1ftfA:
undetectable		 1xdkB-1ftfA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gm5 RECG

(Thermotoga
maritima) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF17190
(RecG_N)
PF17191
(RecG_wedge) 		3 LEU A 671
PHE A 708
ARG A 680
 None
 0.84A 1xdkB-1gm5A:
0.0		 1xdkB-1gm5A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ile ISOLEUCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		3 LEU A 101
PHE A 115
ARG A 391
 None
 0.71A 1xdkB-1ileA:
0.0		 1xdkB-1ileA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lcy HTRA2 SERINE
PROTEASE

(Homo sapiens) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		3 LEU A 133
PHE A 170
ARG A  74
 None
 0.85A 1xdkB-1lcyA:
undetectable		 1xdkB-1lcyA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mov GFP-LIKE
NON-FLUORESCENT
CHROMOPROTEIN

(Montipora
efflorescens) 		PF01353
(GFP) 		3 LEU A  54
PHE A  27
ARG A  95
 None
None
CRQ  A  66 ( 2.9A)
 0.89A 1xdkB-1movA:
undetectable		 1xdkB-1movA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pjm IMPORTIN ALPHA-2
SUBUNIT

(Mus musculus) 		PF00514
(Arm)
PF16186
(Arm_3) 		3 LEU B 144
PHE B 124
ARG B 106
 None
 0.63A 1xdkB-1pjmB:
undetectable		 1xdkB-1pjmB:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		3 LEU A 312
PHE A 308
ARG A 262
 None
NDG  A 804 (-4.9A)
NAG  A 805 ( 4.6A)
 0.89A 1xdkB-1q5aA:
undetectable		 1xdkB-1q5aA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4y RIBONUCLEASE
ALPHA-SARCIN

(Aspergillus
giganteus) 		no annotation 3 LEU A 133
PHE A  57
ARG A  52
 None
 0.90A 1xdkB-1r4yA:
undetectable		 1xdkB-1r4yA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sk7 HYPOTHETICAL PROTEIN
PA-HO

(Pseudomonas
aeruginosa) 		PF01126
(Heme_oxygenase) 		3 LEU A 138
PHE A  45
ARG A 154
 None
 0.85A 1xdkB-1sk7A:
undetectable		 1xdkB-1sk7A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1taq TAQ DNA POLYMERASE

(Thermus
aquaticus) 		PF00476
(DNA_pol_A)
PF01367
(5_3_exonuc)
PF02739
(5_3_exonuc_N)
PF09281
(Taq-exonuc) 		3 LEU A 574
PHE A 564
ARG A 595
 None
 0.61A 1xdkB-1taqA:
undetectable		 1xdkB-1taqA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tki TITIN

(Homo sapiens) 		PF00069
(Pkinase) 		3 LEU A  72
PHE A 165
ARG A  78
 None
 0.87A 1xdkB-1tkiA:
undetectable		 1xdkB-1tkiA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txd RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 12

(Homo sapiens) 		PF00621
(RhoGEF) 		3 LEU A 926
PHE A 813
ARG A 923
 None
 0.84A 1xdkB-1txdA:
undetectable		 1xdkB-1txdA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tyk TOXIN GSMTX-4

(Grammostola
rosea) 		PF07740
(Toxin_12) 		3 LEU A  26
PHE A  27
ARG A  18
 None
 0.87A 1xdkB-1tykA:
undetectable		 1xdkB-1tykA:
5.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v43 SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN

(Pyrococcus
horikoshii) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		3 LEU A 260
PHE A 287
ARG A 310
 None
 0.69A 1xdkB-1v43A:
undetectable		 1xdkB-1v43A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w1w STRUCTURAL
MAINTENANCE OF
CHROMOSOME 1

(Saccharomyces
cerevisiae) 		PF02463
(SMC_N) 		3 LEU A 135
PHE A 134
ARG A   3
 None
 0.86A 1xdkB-1w1wA:
undetectable		 1xdkB-1w1wA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wve 4-CRESOL
DEHYDROGENASE
[HYDROXYLATING]
FLAVOPROTEIN SUBUNIT

(Pseudomonas
putida) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		3 LEU A 462
PHE A 479
ARG A 453
 None
 0.76A 1xdkB-1wveA:
undetectable		 1xdkB-1wveA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)

(Thermus
thermophilus) 		PF02347
(GDC-P) 		3 LEU B 325
PHE B 324
ARG B 335
 None
 0.85A 1xdkB-1wytB:
undetectable		 1xdkB-1wytB:
20.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xap RETINOIC ACID
RECEPTOR BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		3 LEU A 224
PHE A 279
ARG A 387
 TTB  A   1 (-4.4A)
TTB  A   1 (-4.6A)
None
 0.19A 1xdkB-1xapA:
37.1		 1xdkB-1xapA:
92.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xi8 MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN

(Pyrococcus
furiosus) 		PF00994
(MoCF_biosynth)
PF03453
(MoeA_N)
PF03454
(MoeA_C) 		3 LEU A 309
PHE A 345
ARG A 222
 None
 0.87A 1xdkB-1xi8A:
undetectable		 1xdkB-1xi8A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzy HYPOTHETICAL PROTEIN
HI1011

(Haemophilus
influenzae) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		3 LEU A 151
PHE A  84
ARG A 191
 None
 0.87A 1xdkB-1yzyA:
undetectable		 1xdkB-1yzyA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zh4 KDP OPERON
TRANSCRIPTIONAL
REGULATORY PROTEIN
KDPE

(Escherichia
coli) 		PF00072
(Response_reg) 		3 LEU A  51
PHE A  63
ARG A  44
 None
 0.88A 1xdkB-1zh4A:
undetectable		 1xdkB-1zh4A:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zrt CYTOCHROME C1

(Rhodobacter
capsulatus) 		PF02167
(Cytochrom_C1) 		3 LEU D  23
PHE D 212
ARG D  46
 None
 0.85A 1xdkB-1zrtD:
undetectable		 1xdkB-1zrtD:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b8e CATION-TRANSPORTING
ATPASE

(Archaeoglobus
fulgidus) 		PF00702
(Hydrolase) 		3 LEU A 429
PHE A 423
ARG A 652
 None
 0.88A 1xdkB-2b8eA:
undetectable		 1xdkB-2b8eA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c9i GREEN FLUORESCENT
PROTEIN ASFP499

(Anemonia
sulcata) 		PF01353
(GFP) 		3 LEU A  51
PHE A  24
ARG A  92
 None
None
CRQ  A  63 ( 3.1A)
 0.83A 1xdkB-2c9iA:
undetectable		 1xdkB-2c9iA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2crp REGULATOR OF
G-PROTEIN SIGNALING
5

(Homo sapiens) 		PF00615
(RGS) 		3 LEU A  32
PHE A  42
ARG A 121
 None
 0.81A 1xdkB-2crpA:
undetectable		 1xdkB-2crpA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dc1 L-ASPARTATE
DEHYDROGENASE

(Archaeoglobus
fulgidus) 		PF01958
(DUF108)
PF03447
(NAD_binding_3) 		3 LEU A  91
PHE A  85
ARG A 103
 None
 0.82A 1xdkB-2dc1A:
undetectable		 1xdkB-2dc1A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dr3 UPF0273 PROTEIN
PH0284

(Pyrococcus
horikoshii) 		PF06745
(ATPase) 		3 LEU A  28
PHE A  39
ARG A   4
 None
 0.70A 1xdkB-2dr3A:
undetectable		 1xdkB-2dr3A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ewy BETA-SECRETASE 2

(Homo sapiens) 		PF00026
(Asp) 		3 LEU A 137
PHE A 153
ARG A 363
 None
 0.88A 1xdkB-2ewyA:
undetectable		 1xdkB-2ewyA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gai DNA TOPOISOMERASE I

(Thermotoga
maritima) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		3 LEU A 201
PHE A 419
ARG A 386
 None
 0.88A 1xdkB-2gaiA:
undetectable		 1xdkB-2gaiA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h5r MSTRAWBERRY

(Discosoma sp.) 		PF01353
(GFP) 		3 LEU A  54
PHE A  27
ARG A  95
 None
None
CRO  A  66 ( 2.9A)
 0.80A 1xdkB-2h5rA:
undetectable		 1xdkB-2h5rA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8q RED FLUORESCENT
PROTEIN DRFP583

(Discosoma sp.) 		PF01353
(GFP) 		3 LEU A  54
PHE A  27
ARG A  95
 None
None
CRQ  A  66 ( 3.0A)
 0.85A 1xdkB-2h8qA:
undetectable		 1xdkB-2h8qA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hst EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1

(Homo sapiens) 		PF03464
(eRF1_2) 		3 LEU A 212
PHE A 158
ARG A 203
 None
 0.86A 1xdkB-2hstA:
undetectable		 1xdkB-2hstA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2htv NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 LEU A 240
PHE A 275
ARG A 355
 None
 0.86A 1xdkB-2htvA:
undetectable		 1xdkB-2htvA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i2x METHYLTRANSFERASE 1

(Methanosarcina
barkeri) 		PF12176
(MtaB) 		3 LEU A 147
PHE A 146
ARG A 123
 None
 0.88A 1xdkB-2i2xA:
undetectable		 1xdkB-2i2xA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iqc FANCONI ANEMIA GROUP
F PROTEIN

(Homo sapiens) 		PF11107
(FANCF) 		3 LEU A 196
PHE A 201
ARG A 187
 None
 0.71A 1xdkB-2iqcA:
undetectable		 1xdkB-2iqcA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iw0 CHITIN DEACETYLASE

(Colletotrichum
lindemuthianum) 		PF01522
(Polysacc_deac_1) 		3 LEU A 220
PHE A 188
ARG A 230
 None
 0.64A 1xdkB-2iw0A:
undetectable		 1xdkB-2iw0A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iy4 NON-HEME
IRON-CONTAINING
FERRITIN

(Listeria
monocytogenes) 		PF00210
(Ferritin) 		3 LEU A 119
PHE A  12
ARG A 110
 None
 0.73A 1xdkB-2iy4A:
undetectable		 1xdkB-2iy4A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7n RNA-DEPENDENT RNA
POLYMERASE

(Neurospora
crassa) 		PF05183
(RdRP) 		3 LEU A 651
PHE A 583
ARG A 528
 None
 0.90A 1xdkB-2j7nA:
undetectable		 1xdkB-2j7nA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jii SERINE/THREONINE-PRO
TEIN KINASE VRK3
MOLECULE: VACCINIA
RELATED KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		3 LEU A 262
PHE A 313
ARG A 174
 None
 0.88A 1xdkB-2jiiA:
undetectable		 1xdkB-2jiiA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kfu RV1827 PTHR 22

(Mycobacterium
tuberculosis) 		PF00498
(FHA) 		3 LEU A  58
PHE A 146
ARG A 123
 None
 0.78A 1xdkB-2kfuA:
undetectable		 1xdkB-2kfuA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq2 HYPOTHETICAL ABC
TRANSPORTER
ATP-BINDING PROTEIN
HI1470

(Haemophilus
influenzae) 		PF00005
(ABC_tran) 		3 LEU C 171
PHE C 184
ARG C 213
 None
 0.87A 1xdkB-2nq2C:
undetectable		 1xdkB-2nq2C:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o26 KIT LIGAND
MAST/STEM CELL
GROWTH FACTOR
RECEPTOR

(Mus musculus) 		PF02404
(SCF)
no annotation 		3 LEU X 125
PHE X 201
ARG A 104
 None
 0.66A 1xdkB-2o26X:
undetectable		 1xdkB-2o26X:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ohf GTP-BINDING PROTEIN
9

(Homo sapiens) 		PF01926
(MMR_HSR1)
PF06071
(YchF-GTPase_C) 		3 LEU A  88
PHE A 300
ARG A 317
 None
 0.85A 1xdkB-2ohfA:
undetectable		 1xdkB-2ohfA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ok8 PUTATIVE
FERREDOXIN--NADP
REDUCTASE

(Plasmodium
falciparum) 		PF00175
(NAD_binding_1) 		3 LEU A  16
PHE A  46
ARG A  98
 None
 0.81A 1xdkB-2ok8A:
undetectable		 1xdkB-2ok8A:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p22 SUPPRESSOR PROTEIN
STP22 OF
TEMPERATURE-SENSITIV
E ALPHA-FACTOR
RECEPTOR AND
ARGININE PERMEASE
VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 28

(Saccharomyces
cerevisiae) 		PF03997
(VPS28)
PF09454
(Vps23_core) 		3 LEU A 372
PHE A 371
ARG B 114
 None
 0.86A 1xdkB-2p22A:
undetectable		 1xdkB-2p22A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p5x N-ACETYLSEROTONIN
O-METHYLTRANSFERASE-
LIKE PROTEIN

(Homo sapiens) 		PF02545
(Maf) 		3 LEU A  33
PHE A  35
ARG A  23
 None
 0.81A 1xdkB-2p5xA:
undetectable		 1xdkB-2p5xA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pok PEPTIDASE,
M20/M25/M40 FAMILY

(Streptococcus
pneumoniae) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		3 LEU A 296
PHE A 295
ARG A 334
 None
 0.82A 1xdkB-2pokA:
undetectable		 1xdkB-2pokA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q01 URONATE ISOMERASE

(Caulobacter
vibrioides) 		PF02614
(UxaC) 		3 LEU A 131
PHE A 105
ARG A  11
 None
 0.87A 1xdkB-2q01A:
undetectable		 1xdkB-2q01A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qdj RETINOBLASTOMA-ASSOC
IATED PROTEIN

(Homo sapiens) 		PF11934
(DUF3452) 		3 LEU A  64
PHE A 115
ARG A  73
 None
 0.63A 1xdkB-2qdjA:
2.6		 1xdkB-2qdjA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qni UNCHARACTERIZED
PROTEIN ATU0299

(Agrobacterium
fabrum) 		PF00300
(His_Phos_1) 		3 LEU A 149
PHE A 200
ARG A 140
 None
 0.74A 1xdkB-2qniA:
undetectable		 1xdkB-2qniA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qsv UNCHARACTERIZED
PROTEIN

(Porphyromonas
gingivalis) 		PF07610
(DUF1573) 		3 LEU A  67
PHE A  12
ARG A  51
 None
 0.89A 1xdkB-2qsvA:
undetectable		 1xdkB-2qsvA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt3 N-ISOPROPYLAMMELIDE
ISOPROPYL
AMIDOHYDROLASE

(Pseudomonas sp.
ADP) 		PF01979
(Amidohydro_1) 		3 LEU A 261
PHE A 253
ARG A 231
 None
 0.81A 1xdkB-2qt3A:
undetectable		 1xdkB-2qt3A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qv2 INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1

(Homo sapiens) 		PF00620
(RhoGAP) 		3 LEU A 310
PHE A 331
ARG A 274
 LEU  A 310 ( 0.6A)
PHE  A 331 ( 1.3A)
ARG  A 274 ( 0.6A)
 0.72A 1xdkB-2qv2A:
undetectable		 1xdkB-2qv2A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7m 5-FORMAMINOIMIDAZOLE
-4-CARBOXAMIDE-1-(BE
TA)-D-RIBOFURANOSYL
5'-MONOPHOSPHATE
SYNTHETASE

(Methanocaldococcus
jannaschii) 		PF06849
(DUF1246)
PF06973
(DUF1297) 		3 LEU A  24
PHE A  95
ARG A  83
 None
 0.85A 1xdkB-2r7mA:
undetectable		 1xdkB-2r7mA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rch CYTOCHROME P450 74A

(Arabidopsis
thaliana) 		PF00067
(p450) 		3 LEU A 221
PHE A 220
ARG A 179
 None
 0.84A 1xdkB-2rchA:
undetectable		 1xdkB-2rchA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rv8 DNA-BINDING RESPONSE
REGULATOR

(Mycobacterium
tuberculosis) 		PF00486
(Trans_reg_C) 		3 LEU A 243
PHE A 185
ARG A 237
 None
 0.86A 1xdkB-2rv8A:
undetectable		 1xdkB-2rv8A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vad RED FLUORESCENT
PROTEIN

(Discosoma sp.) 		PF01353
(GFP) 		3 LEU A  54
PHE A  27
ARG A  95
 None
None
CRQ  A  66 ( 2.9A)
 0.88A 1xdkB-2vadA:
undetectable		 1xdkB-2vadA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vjw GAF FAMILY PROTEIN

(Mycolicibacterium
smegmatis) 		PF01590
(GAF) 		3 LEU A 247
PHE A 355
ARG A 238
 None
 0.80A 1xdkB-2vjwA:
undetectable		 1xdkB-2vjwA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2voy CATION-TRANSPORTING
ATPASE

(Archaeoglobus
fulgidus) 		PF00702
(Hydrolase) 		3 LEU I 429
PHE I 423
ARG I 652
 None
 0.88A 1xdkB-2voyI:
undetectable		 1xdkB-2voyI:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsq SURFACTIN SYNTHETASE
SUBUNIT 3

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		3 LEU A  83
PHE A   4
ARG A 128
 None
 0.89A 1xdkB-2vsqA:
undetectable		 1xdkB-2vsqA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w9x PUTATIVE ACETYL
XYLAN ESTERASE

(Cellvibrio
japonicus) 		PF00657
(Lipase_GDSL) 		3 LEU A  66
PHE A 127
ARG A  78
 None
 0.88A 1xdkB-2w9xA:
undetectable		 1xdkB-2w9xA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wa5 FILAMIN-B

(Homo sapiens) 		PF00307
(CH) 		3 LEU A 174
PHE A 237
ARG A 199
 None
 0.81A 1xdkB-2wa5A:
undetectable		 1xdkB-2wa5A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wmp PAPG PROTEIN

(Escherichia
coli) 		PF03628
(PapG_C) 		3 LEU B 287
PHE B 237
ARG B 198
 None
 0.88A 1xdkB-2wmpB:
undetectable		 1xdkB-2wmpB:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3a PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT BETA ISOFORM

(Mus musculus) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B) 		3 LEU A 242
PHE A 275
ARG A 662
 None
 0.79A 1xdkB-2y3aA:
undetectable		 1xdkB-2y3aA:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y6i COLLAGENASE

(Hathewaya
histolytica) 		PF01752
(Peptidase_M9)
PF08453
(Peptidase_M9_N) 		3 LEU A 617
PHE A 625
ARG A 573
 None
 0.76A 1xdkB-2y6iA:
undetectable		 1xdkB-2y6iA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yik ENDOGLUCANASE

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9) 		3 LEU A 100
PHE A 170
ARG A  78
 None
 0.63A 1xdkB-2yikA:
undetectable		 1xdkB-2yikA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yp1 AROMATIC
PEROXYGENASE

(Agrocybe
aegerita) 		PF01328
(Peroxidase_2) 		3 LEU A  83
PHE A 311
ARG A 189
 None
None
HEM  A 350 (-3.3A)
 0.90A 1xdkB-2yp1A:
undetectable		 1xdkB-2yp1A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yuj UBIQUITIN FUSION
DEGRADATION 1-LIKE

(Homo sapiens) 		PF03152
(UFD1) 		3 LEU A  50
PHE A  82
ARG A  15
 None
 0.71A 1xdkB-2yujA:
undetectable		 1xdkB-2yujA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z99 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
tuberculosis) 		PF04079
(SMC_ScpB) 		3 LEU A 152
PHE A 173
ARG A 124
 None
 0.87A 1xdkB-2z99A:
undetectable		 1xdkB-2z99A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zo6 CYAN-EMITTING
GFP-LIKE PROTEIN,
KUSABIRA-CYAN (KCY)

(Verrillofungia
concinna) 		PF01353
(GFP) 		3 LEU A  50
PHE A  23
ARG A  91
 None
None
GYS  A  63 ( 3.0A)
 0.78A 1xdkB-2zo6A:
undetectable		 1xdkB-2zo6A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zo7 CYAN/GREEN-EMITTING
GFP-LIKE PROTEIN,
KUSABIRA-CYAN MUTANT
(KCY-R1)

(Verrillofungia
concinna) 		PF01353
(GFP) 		3 LEU A  51
PHE A  24
ARG A  92
 None
None
GYS  A  64 ( 2.9A)
 0.78A 1xdkB-2zo7A:
undetectable		 1xdkB-2zo7A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahm OLIGOPEPTIDASE

(Geobacillus sp.
MO-1) 		no annotation 3 LEU A 162
PHE A 152
ARG A 171
 None
 0.83A 1xdkB-3ahmA:
undetectable		 1xdkB-3ahmA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3axs PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1

(Aquifex
aeolicus) 		PF02005
(TRM) 		3 LEU A 194
PHE A 221
ARG A 182
 None
 0.89A 1xdkB-3axsA:
undetectable		 1xdkB-3axsA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3boh CADMIUM-SPECIFIC
CARBONIC ANHYDRASE

(Conticribra
weissflogii) 		no annotation 3 LEU A  85
PHE A 136
ARG A  80
 None
 0.80A 1xdkB-3bohA:
undetectable		 1xdkB-3bohA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bpo INTERLEUKIN-13
RECEPTOR ALPHA-1
CHAIN

(Homo sapiens) 		PF09240
(IL6Ra-bind) 		3 LEU C 258
PHE C 253
ARG C 225
 LEU  C 258 ( 0.5A)
PHE  C 253 ( 1.3A)
ARG  C 225 ( 0.6A)
 0.76A 1xdkB-3bpoC:
undetectable		 1xdkB-3bpoC:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bs5 CONNECTOR ENHANCER
OF KINASE SUPPRESSOR
OF RAS 2
PROTEIN AVEUGLE

(Drosophila
melanogaster;
Homo sapiens) 		PF00536
(SAM_1)
PF07647
(SAM_2) 		3 LEU B 160
PHE B 139
ARG A  61
 None
 0.79A 1xdkB-3bs5B:
undetectable		 1xdkB-3bs5B:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgl GFP-LIKE FLUORESCENT
CHROMOPROTEIN
DSFP483

(Discosoma
striata) 		PF01353
(GFP) 		3 LEU A  54
PHE A  27
ARG A  95
 None
None
CRQ  A  66 ( 3.0A)
 0.90A 1xdkB-3cglA:
undetectable		 1xdkB-3cglA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cr8 SULFATE
ADENYLYLTRANSFERASE,
ADENYLYLSULFATE
KINASE

(Thiobacillus
denitrificans) 		PF01583
(APS_kinase)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		3 LEU A 330
PHE A 335
ARG A 223
 None
 0.84A 1xdkB-3cr8A:
undetectable		 1xdkB-3cr8A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwc PUTATIVE GLYCERATE
KINASE 2

(Salmonella
enterica) 		PF02595
(Gly_kinase) 		3 LEU A 237
PHE A 260
ARG A 228
 None
 0.82A 1xdkB-3cwcA:
undetectable		 1xdkB-3cwcA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddd PUTATIVE
ACETYLTRANSFERASE

(Pyrococcus
horikoshii) 		PF00583
(Acetyltransf_1) 		3 LEU A 114
PHE A  89
ARG A 246
 COA  A 300 (-4.1A)
None
None
 0.68A 1xdkB-3dddA:
undetectable		 1xdkB-3dddA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dob HEAT SHOCK 70 KDA
PROTEIN F44E5.5

(Caenorhabditis
elegans) 		PF00012
(HSP70) 		3 LEU A 543
PHE A 429
ARG A 534
 None
 0.87A 1xdkB-3dobA:
undetectable		 1xdkB-3dobA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eyx CARBONIC ANHYDRASE

(Saccharomyces
cerevisiae) 		PF00484
(Pro_CA) 		3 LEU A  67
PHE A  54
ARG A  61
 None
 0.87A 1xdkB-3eyxA:
undetectable		 1xdkB-3eyxA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN

(Geobacillus
kaustophilus) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		3 LEU A1379
PHE A1372
ARG A1429
 None
 0.89A 1xdkB-3f2bA:
undetectable		 1xdkB-3f2bA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f70 LETHAL(3)MALIGNANT
BRAIN TUMOR-LIKE 2
PROTEIN

(Homo sapiens) 		PF02820
(MBT) 		3 LEU A 459
PHE A 428
ARG A 564
 None
 0.83A 1xdkB-3f70A:
undetectable		 1xdkB-3f70A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3frq REPRESSOR PROTEIN
MPHR(A)

(Escherichia
coli) 		PF00440
(TetR_N) 		3 LEU A  55
PHE A  28
ARG A  47
 None
 0.84A 1xdkB-3frqA:
undetectable		 1xdkB-3frqA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gg4 GLYCEROL KINASE

(Yersinia
pseudotuberculosis) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		3 LEU A 425
PHE A 527
ARG A 388
 None
 0.86A 1xdkB-3gg4A:
undetectable		 1xdkB-3gg4A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hoc FILAMIN-A

(Homo sapiens) 		PF00307
(CH) 		3 LEU A 201
PHE A 264
ARG A 226
 None
 0.70A 1xdkB-3hocA:
undetectable		 1xdkB-3hocA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hqf RESTRICTION
ENDONUCLEASE

(Escherichia
coli) 		PF09217
(EcoRII-N) 		3 LEU A  50
PHE A 122
ARG A  98
 None
 0.86A 1xdkB-3hqfA:
undetectable		 1xdkB-3hqfA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j5y EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1

(Homo sapiens) 		PF03463
(eRF1_1)
PF03464
(eRF1_2)
PF03465
(eRF1_3) 		3 LEU A 212
PHE A 158
ARG A 203
 None
 0.77A 1xdkB-3j5yA:
undetectable		 1xdkB-3j5yA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcm PRE-MRNA-SPLICING
FACTOR 6

(Saccharomyces
cerevisiae) 		PF06424
(PRP1_N) 		3 LEU G 780
PHE G 781
ARG G 800
 None
 0.76A 1xdkB-3jcmG:
undetectable		 1xdkB-3jcmG:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksm ABC-TYPE SUGAR
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT

(Hahella
chejuensis) 		PF13407
(Peripla_BP_4) 		3 LEU A 170
PHE A 187
ARG A 166
 None
 0.82A 1xdkB-3ksmA:
undetectable		 1xdkB-3ksmA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzh PROBABLE SUGAR
KINASE

(Clostridium
perfringens) 		PF00294
(PfkB) 		3 LEU A 154
PHE A 163
ARG A 131
 None
 0.89A 1xdkB-3kzhA:
undetectable		 1xdkB-3kzhA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lf4 FLUORESCENT TIMER
PRECURSOR BLUE102

(Discosoma sp.) 		PF01353
(GFP) 		3 LEU A  54
PHE A  27
ARG B  95
 None
None
0YG  B  67 ( 3.0A)
 0.82A 1xdkB-3lf4A:
undetectable		 1xdkB-3lf4A:
10.89