SIMILAR PATTERNS OF AMINO ACIDS FOR 1XDK_A_9CRA500_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bsg BETA LACTAMASE

(Streptomyces
albus)
PF13354
(Beta-lactamase2)
5 ALA A 280
PHE A 221
ALA A 223
VAL A  57
LEU A  44
None
1.05A 1xdkA-1bsgA:
undetectable
1xdkA-1bsgA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ci9 PROTEIN
(CARBOXYLESTERASE)


(Burkholderia
gladioli)
PF00144
(Beta-lactamase)
5 ALA A 306
GLN A 310
ALA A 305
VAL A 192
LEU A 185
None
1.12A 1xdkA-1ci9A:
undetectable
1xdkA-1ci9A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e19 CARBAMATE KINASE

(Pyrococcus
furiosus)
PF00696
(AA_kinase)
6 ILE A  37
ALA A  34
LEU A  97
ALA A  96
VAL A   5
LEU A 234
None
0.90A 1xdkA-1e19A:
undetectable
1xdkA-1e19A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1faf LARGE T ANTIGEN

(Mus musculus
polyomavirus 1)
no annotation 5 ALA A  33
GLN A  37
ASN A  56
LEU A  19
VAL A  66
None
1.03A 1xdkA-1fafA:
undetectable
1xdkA-1fafA:
15.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hg4 ULTRASPIRACLE

(Drosophila
melanogaster)
PF00104
(Hormone_recep)
5 TRP A 318
LEU A 366
VAL A 382
CYH A 472
LEU A 476
None
LPP  A   1 ( 4.4A)
LPP  A   1 (-4.8A)
LPP  A   1 ( 4.2A)
LPP  A   1 (-4.2A)
0.71A 1xdkA-1hg4A:
24.7
1xdkA-1hg4A:
43.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mg5 ALCOHOL
DEHYDROGENASE


(Drosophila
melanogaster)
PF00106
(adh_short)
5 ILE A 226
ALA A 225
ASN A 136
PHE A 222
VAL A   9
None
1.11A 1xdkA-1mg5A:
undetectable
1xdkA-1mg5A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n4d VITAMIN B12
TRANSPORT PROTEIN
BTUF


(Escherichia
coli)
PF01497
(Peripla_BP_2)
5 ILE A  90
ALA A  94
LEU A 117
ALA A 114
VAL A 160
None
1.10A 1xdkA-1n4dA:
undetectable
1xdkA-1n4dA:
24.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r20 ULTRASPIRACLE
PROTEIN


(Heliothis
virescens)
PF00104
(Hormone_recep)
5 TRP A 286
ARG A 297
LEU A 325
VAL A 341
LEU A 435
None
None
None
EPH  A4000 (-4.9A)
EPH  A4000 ( 4.6A)
0.73A 1xdkA-1r20A:
24.4
1xdkA-1r20A:
45.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sjp 60 KDA CHAPERONIN 2

(Mycobacterium
tuberculosis)
PF00118
(Cpn60_TCP1)
5 ASN A 262
PHE A 201
ALA A 210
VAL A 224
LEU A 234
None
1.06A 1xdkA-1sjpA:
undetectable
1xdkA-1sjpA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sjp 60 KDA CHAPERONIN 2

(Mycobacterium
tuberculosis)
PF00118
(Cpn60_TCP1)
5 ILE A 246
ASN A 262
PHE A 201
VAL A 224
LEU A 234
None
0.87A 1xdkA-1sjpA:
undetectable
1xdkA-1sjpA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1srv PROTEIN (GROEL
(HSP60 CLASS))


(Thermus
thermophilus)
PF00118
(Cpn60_TCP1)
5 ASN A 265
PHE A 204
ALA A 213
VAL A 227
LEU A 237
None
1.00A 1xdkA-1srvA:
undetectable
1xdkA-1srvA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1srv PROTEIN (GROEL
(HSP60 CLASS))


(Thermus
thermophilus)
PF00118
(Cpn60_TCP1)
5 ILE A 249
ASN A 265
PHE A 204
VAL A 227
LEU A 237
None
0.88A 1xdkA-1srvA:
undetectable
1xdkA-1srvA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tf1 NEGATIVE REGULATOR
OF ALLANTOIN AND
GLYOXYLATE
UTILIZATION OPERONS


(Escherichia
coli)
PF01614
(IclR)
5 ILE A  36
ALA A 147
LEU A  75
ALA A  74
LEU A  14
None
1.14A 1xdkA-1tf1A:
undetectable
1xdkA-1tf1A:
23.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uhl RETINOIC ACID
RECEPTOR RXR-BETA


(Homo sapiens)
PF00104
(Hormone_recep)
12 ILE A 339
ALA A 342
GLN A 346
TRP A 376
ASN A 377
PHE A 384
ARG A 387
LEU A 397
ALA A 398
VAL A 413
CYH A 503
LEU A 507
MEI  A1001 (-3.8A)
MEI  A1001 (-3.1A)
None
None
None
MEI  A1001 (-4.5A)
MEI  A1001 (-3.6A)
MEI  A1001 ( 4.4A)
MEI  A1001 (-3.4A)
MEI  A1001 (-4.1A)
MEI  A1001 (-4.0A)
MEI  A1001 (-4.6A)
0.61A 1xdkA-1uhlA:
35.2
1xdkA-1uhlA:
87.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x3l HYPOTHETICAL PROTEIN
PH0495


(Pyrococcus
horikoshii)
PF05161
(MOFRL)
PF13660
(DUF4147)
5 ALA A  55
LEU A 128
ALA A  64
VAL A 260
LEU A 116
None
None
None
EDO  A 502 (-4.3A)
None
1.13A 1xdkA-1x3lA:
undetectable
1xdkA-1x3lA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x3l HYPOTHETICAL PROTEIN
PH0495


(Pyrococcus
horikoshii)
PF05161
(MOFRL)
PF13660
(DUF4147)
5 ILE A  67
ALA A  64
ALA A  55
VAL A  33
LEU A  28
None
1.14A 1xdkA-1x3lA:
undetectable
1xdkA-1x3lA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x3l HYPOTHETICAL PROTEIN
PH0495


(Pyrococcus
horikoshii)
PF05161
(MOFRL)
PF13660
(DUF4147)
5 ILE A 127
ALA A  55
ALA A  64
VAL A 260
LEU A 116
None
None
None
EDO  A 502 (-4.3A)
None
1.10A 1xdkA-1x3lA:
undetectable
1xdkA-1x3lA:
21.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xiu RXR-LIKE PROTEIN

(Biomphalaria
glabrata)
PF00104
(Hormone_recep)
12 ILE A 242
ALA A 245
GLN A 249
TRP A 279
ASN A 280
PHE A 287
ARG A 290
LEU A 300
ALA A 301
VAL A 316
CYH A 406
LEU A 410
9CR  A 201 ( 4.4A)
9CR  A 201 (-3.6A)
9CR  A 201 (-4.1A)
None
None
9CR  A 201 (-4.7A)
9CR  A 201 (-2.8A)
9CR  A 201 (-4.4A)
9CR  A 201 (-3.4A)
9CR  A 201 (-4.2A)
9CR  A 201 (-3.6A)
9CR  A 201 ( 4.8A)
0.46A 1xdkA-1xiuA:
31.6
1xdkA-1xiuA:
81.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xls RETINOIC ACID
RECEPTOR RXR-ALPHA


(Homo sapiens)
PF00104
(Hormone_recep)
12 ILE A 268
ALA A 271
GLN A 275
TRP A 305
ASN A 306
PHE A 313
ARG A 316
LEU A 326
ALA A 327
VAL A 342
CYH A 432
LEU A 436
9CR  A 801 (-3.9A)
9CR  A 801 (-3.6A)
9CR  A 801 (-4.7A)
None
None
9CR  A 801 (-4.3A)
9CR  A 801 (-2.6A)
9CR  A 801 (-4.1A)
9CR  A 801 (-3.3A)
9CR  A 801 ( 4.3A)
9CR  A 801 ( 3.7A)
9CR  A 801 (-4.7A)
0.40A 1xdkA-1xlsA:
34.9
1xdkA-1xlsA:
99.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ykw RUBISCO-LIKE PROTEIN

(Chlorobaculum
tepidum)
PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N)
5 ILE A 239
ALA A 253
ALA A 215
VAL A 268
LEU A 284
None
1.13A 1xdkA-1ykwA:
undetectable
1xdkA-1ykwA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z69 COENZYME
F420-DEPENDENT
N(5),N(10)-METHYLENE
TETRAHYDROMETHANOPTE
RIN REDUCTASE


(Methanosarcina
barkeri)
PF00296
(Bac_luciferase)
5 ILE A 258
ALA A 257
PHE A 263
LEU A 266
ALA A 265
None
1.05A 1xdkA-1z69A:
undetectable
1xdkA-1z69A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ayx SENSOR KINASE
PROTEIN RCSC


(Escherichia
coli)
PF00072
(Response_reg)
PF09456
(RcsC)
5 ALA A 787
ARG A 767
LEU A 718
ALA A 786
VAL A 746
None
1.03A 1xdkA-2ayxA:
undetectable
1xdkA-2ayxA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpl GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT B


(Pyrococcus
horikoshii)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase)
5 ASN A  54
PHE A  88
LEU A  91
ALA A  90
VAL A 209
None
1.14A 1xdkA-2dplA:
undetectable
1xdkA-2dplA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fv2 RCD1 REQUIRED FOR
CELL
DIFFERENTIATION1
HOMOLOG


(Homo sapiens)
PF04078
(Rcd1)
5 ALA A  85
GLN A  82
LEU A 130
ALA A 129
LEU A  51
None
0.82A 1xdkA-2fv2A:
undetectable
1xdkA-2fv2A:
24.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gl8 RETINOIC ACID
RECEPTOR RXR-GAMMA


(Homo sapiens)
PF00104
(Hormone_recep)
7 TRP A  84
PHE A  92
ARG A  95
LEU A 105
ALA A 106
VAL A 121
CYH A 211
None
0.78A 1xdkA-2gl8A:
27.0
1xdkA-2gl8A:
85.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxo PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR


(Streptomyces
coelicolor)
PF00440
(TetR_N)
PF02909
(TetR_C)
5 PHE A 217
LEU A 218
ALA A 219
VAL A  75
LEU A 131
None
1.07A 1xdkA-2hxoA:
undetectable
1xdkA-2hxoA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix5 ACYL-COENZYME A
OXIDASE 4,
PEROXISOMAL


(Arabidopsis
thaliana)
PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
5 ALA A 101
LEU A 166
ALA A 164
VAL A  74
CYH A  69
None
1.01A 1xdkA-2ix5A:
undetectable
1xdkA-2ix5A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mqa MINOR AMPULLATE
FIBROIN 1


(Nephila
antipodiana)
PF12042
(RP1-2)
5 ILE A 101
ASN A  95
LEU A 105
ALA A 106
VAL A  54
None
1.14A 1xdkA-2mqaA:
undetectable
1xdkA-2mqaA:
18.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2nxx ULTRASPIRACLE (USP,
NR2B4)


(Tribolium
castaneum)
PF00104
(Hormone_recep)
5 PHE A 259
ARG A 262
LEU A 272
ALA A 273
CYH A 378
None
0.77A 1xdkA-2nxxA:
24.6
1xdkA-2nxxA:
62.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6i HD DOMAIN PROTEIN

(Enterococcus
faecalis)
PF01966
(HD)
5 ALA A 332
ASN A 365
PHE A 334
LEU A 452
ALA A 451
None
1.14A 1xdkA-2o6iA:
undetectable
1xdkA-2o6iA:
19.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q60 RETINOID X RECEPTOR

(Polyandrocarpa
misakiensis)
PF00104
(Hormone_recep)
7 TRP A 180
ASN A 181
PHE A 188
ARG A 191
ALA A 202
VAL A 217
CYH A 307
None
0.53A 1xdkA-2q60A:
26.9
1xdkA-2q60A:
72.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q8w POKEWEED ANTIVIRAL
PROTEIN


(Phytolacca
acinosa)
PF00161
(RIP)
5 ILE A 214
ALA A 217
ARG A 240
LEU A 222
ALA A 221
None
0.98A 1xdkA-2q8wA:
undetectable
1xdkA-2q8wA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qde MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN


(Aromatoleum
aromaticum)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 ILE A  69
ALA A 103
GLN A 102
VAL A 387
LEU A  38
None
1.12A 1xdkA-2qdeA:
undetectable
1xdkA-2qdeA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qes RIBOSOME-INACTIVATIN
G PROTEIN PD-L4


(Phytolacca
dioica)
PF00161
(RIP)
5 ILE A 214
ALA A 217
ARG A 240
LEU A 222
ALA A 221
None
1.09A 1xdkA-2qesA:
undetectable
1xdkA-2qesA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)


(Saccharomyces
cerevisiae)
PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT)
5 ILE G 283
LEU G 246
ALA G 247
VAL G 459
LEU G 267
None
1.13A 1xdkA-2uv8G:
undetectable
1xdkA-2uv8G:
8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wkn FORMAMIDASE

(Delftia
acidovorans)
PF03069
(FmdA_AmdA)
5 ALA A 244
TRP A  24
PHE A 237
LEU A  87
VAL A 272
None
1.12A 1xdkA-2wknA:
undetectable
1xdkA-2wknA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0f WSAF

(Geobacillus
stearothermophilus)
no annotation 5 ILE A 137
GLN A 148
ASN A 163
ALA A 144
LEU A 413
None
1.05A 1xdkA-2x0fA:
undetectable
1xdkA-2x0fA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xgo XCOGT

(Xanthomonas
campestris)
PF13432
(TPR_16)
PF13844
(Glyco_transf_41)
5 ALA A 549
PHE A 228
LEU A 231
ALA A 230
LEU A 328
None
1.03A 1xdkA-2xgoA:
undetectable
1xdkA-2xgoA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3am6 RHODOPSIN-2

(Acetabularia
acetabulum)
PF01036
(Bac_rhodopsin)
5 ILE A  44
ALA A  47
VAL A  95
CYH A 218
LEU A 219
None
None
None
None
CLR  A 401 ( 4.6A)
1.01A 1xdkA-3am6A:
undetectable
1xdkA-3am6A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b89 16S RRNA METHYLASE

(Escherichia
coli)
PF07091
(FmrO)
5 ALA A  77
LEU A  69
ALA A  68
VAL A 127
CYH A 112
None
1.09A 1xdkA-3b89A:
undetectable
1xdkA-3b89A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ci0 PSEUDOPILIN GSPK

(Escherichia
coli)
PF03934
(T2SSK)
5 ILE K 218
ALA K 221
LEU K 119
ALA K 118
LEU K 271
None
0.99A 1xdkA-3ci0K:
undetectable
1xdkA-3ci0K:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dh4 SODIUM/GLUCOSE
COTRANSPORTER


(Vibrio
parahaemolyticus)
PF00474
(SSF)
5 ILE A 287
ALA A 291
ASN A 525
LEU A  95
ALA A  92
None
1.07A 1xdkA-3dh4A:
undetectable
1xdkA-3dh4A:
19.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu RETINOIC ACID
RECEPTOR RXR-ALPHA


(Homo sapiens)
PF00104
(Hormone_recep)
PF00105
(zf-C4)
10 ILE A 268
ALA A 271
GLN A 275
TRP A 305
ASN A 306
PHE A 313
ARG A 316
LEU A 326
VAL A 342
LEU A 436
9CR  A7223 (-3.9A)
9CR  A7223 (-3.5A)
9CR  A7223 (-4.6A)
None
9CR  A7223 (-3.9A)
9CR  A7223 (-4.5A)
9CR  A7223 (-3.7A)
9CR  A7223 (-3.8A)
9CR  A7223 ( 4.5A)
9CR  A7223 ( 4.7A)
0.76A 1xdkA-3dzuA:
33.7
1xdkA-3dzuA:
99.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu RETINOIC ACID
RECEPTOR RXR-ALPHA


(Homo sapiens)
PF00104
(Hormone_recep)
PF00105
(zf-C4)
11 ILE A 268
ALA A 271
GLN A 275
TRP A 305
PHE A 313
ARG A 316
LEU A 326
ALA A 327
VAL A 342
CYH A 432
LEU A 436
9CR  A7223 (-3.9A)
9CR  A7223 (-3.5A)
9CR  A7223 (-4.6A)
None
9CR  A7223 (-4.5A)
9CR  A7223 (-3.7A)
9CR  A7223 (-3.8A)
9CR  A7223 ( 4.7A)
9CR  A7223 ( 4.5A)
9CR  A7223 (-3.8A)
9CR  A7223 ( 4.7A)
0.70A 1xdkA-3dzuA:
33.7
1xdkA-3dzuA:
99.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ejb BIOTIN BIOSYNTHESIS
CYTOCHROME P450-LIKE
ENZYME


(Bacillus
subtilis)
PF00067
(p450)
5 ILE B 358
ALA B 270
ASN B 245
LEU B 260
LEU B 242
None
None
None
None
HEM  B 405 ( 4.5A)
1.13A 1xdkA-3ejbB:
undetectable
1xdkA-3ejbB:
23.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3eyb NUCLEAR HORMONE
RECEPTOR RXR


(Branchiostoma
floridae)
PF00104
(Hormone_recep)
6 ASN A 335
PHE A 342
LEU A 355
ALA A 356
VAL A 371
CYH A 461
None
0.90A 1xdkA-3eybA:
28.1
1xdkA-3eybA:
84.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5k RIBOSOME-INACTIVATIN
G PROTEIN
PD-L1/PD-L2


(Phytolacca
dioica)
PF00161
(RIP)
5 ILE A 214
ALA A 217
ARG A 240
LEU A 222
ALA A 221
None
0.96A 1xdkA-3h5kA:
undetectable
1xdkA-3h5kA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hve GIGAXONIN

(Homo sapiens)
PF00651
(BTB)
PF07707
(BACK)
5 ILE A  47
ALA A  50
LEU B  20
ALA B  19
LEU A  87
None
0.69A 1xdkA-3hveA:
undetectable
1xdkA-3hveA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hve GIGAXONIN

(Homo sapiens)
PF00651
(BTB)
PF07707
(BACK)
5 ILE B  47
ALA B  50
LEU A  20
ALA A  19
LEU B  87
None
0.91A 1xdkA-3hveB:
undetectable
1xdkA-3hveB:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iiw POLYCOMB PROTEIN EED

(Homo sapiens)
PF00400
(WD40)
5 ILE A 172
ALA A 164
ASN A 219
LEU A 196
ALA A 151
None
1.13A 1xdkA-3iiwA:
undetectable
1xdkA-3iiwA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iv0 SUSD HOMOLOG

(Bacteroides
thetaiotaomicron)
PF07980
(SusD_RagB)
PF14322
(SusD-like_3)
5 ILE A 121
ALA A 124
ASN A 172
ALA A 149
VAL A 167
None
1.11A 1xdkA-3iv0A:
undetectable
1xdkA-3iv0A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF5


(Schizosaccharomyces
pombe)
PF08082
(PRO8NT)
PF08083
(PROCN)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV)
5 ILE a  46
ALA a 117
GLN a 120
ASN a  78
CYH a  79
None
1.13A 1xdkA-3jb9a:
undetectable
1xdkA-3jb9a:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ktc XYLOSE ISOMERASE

(Pectobacterium
atrosepticum)
PF01261
(AP_endonuc_2)
5 ILE A 292
ALA A 295
LEU A 324
ALA A 323
VAL A 230
None
0.94A 1xdkA-3ktcA:
undetectable
1xdkA-3ktcA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l0g NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE


(Ehrlichia
chaffeensis)
PF01729
(QRPTase_C)
PF02749
(QRPTase_N)
5 ILE A  94
LEU A  13
ALA A  12
VAL A  63
LEU A 271
None
1.07A 1xdkA-3l0gA:
undetectable
1xdkA-3l0gA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2


(Homo sapiens)
PF02020
(W2)
PF02847
(MA3)
5 ALA A 111
GLN A 143
LEU A 144
VAL A 162
LEU A 128
None
None
None
MES  A 361 (-3.6A)
None
1.03A 1xdkA-3l6aA:
undetectable
1xdkA-3l6aA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0u PROBABLE
N-GLYCOSYLASE/DNA
LYASE


(Thermotoga
maritima)
no annotation 5 ALA A  91
GLN A  88
ARG A  80
LEU A  79
ALA A  76
None
1.07A 1xdkA-3n0uA:
undetectable
1xdkA-3n0uA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r3h O-METHYLTRANSFERASE,
SAM-DEPENDENT


(Legionella
pneumophila)
PF01596
(Methyltransf_3)
5 ILE A 142
ALA A 144
LEU A  67
VAL A 217
LEU A 193
None
1.14A 1xdkA-3r3hA:
undetectable
1xdkA-3r3hA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rj9 ALCOHOL
DEHYDROGENASE


(Scaptodrosophila
lebanonensis)
PF00106
(adh_short)
5 ILE A 225
ALA A 224
ASN A 135
PHE A 221
VAL A   8
None
1.13A 1xdkA-3rj9A:
undetectable
1xdkA-3rj9A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N


(Escherichia
coli)
no annotation 5 ILE N 250
ALA N 249
LEU N 119
ALA N 120
LEU N 306
None
0.91A 1xdkA-3rkoN:
undetectable
1xdkA-3rkoN:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rmj 2-ISOPROPYLMALATE
SYNTHASE


(Neisseria
meningitidis)
PF00682
(HMGL-like)
6 ILE A 156
ALA A 159
TRP A 201
PHE A 140
ALA A 163
LEU A 189
None
1.32A 1xdkA-3rmjA:
undetectable
1xdkA-3rmjA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN


(Escherichia
coli)
PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF)
5 ALA A 602
LEU A 622
ALA A 618
VAL A 636
LEU A 655
None
1.01A 1xdkA-3ttfA:
undetectable
1xdkA-3ttfA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uc2 HYPOTHETICAL PROTEIN
WITH
IMMUNOGLOBULIN-LIKE
FOLD


(Pseudomonas
aeruginosa)
PF14467
(DUF4426)
5 ILE A  59
ALA A 103
GLN A 104
PHE A 105
LEU A  88
None
1.03A 1xdkA-3uc2A:
undetectable
1xdkA-3uc2A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3up4 OTEMO

(Pseudomonas
putida)
PF00743
(FMO-like)
5 ILE A 201
ALA A 204
ASN A 343
LEU A 211
ALA A 208
None
1.11A 1xdkA-3up4A:
undetectable
1xdkA-3up4A:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zil AAR187CP

(Eremothecium
gossypii)
PF16997
(Wap1)
6 ILE A 359
ALA A 356
TRP A 338
LEU A 397
ALA A 393
LEU A 335
None
1.41A 1xdkA-3zilA:
undetectable
1xdkA-3zilA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4di5 5-EPI-ARISTOLOCHENE
SYNTHASE


(Nicotiana
tabacum)
PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C)
5 ILE A 432
ALA A 435
ASN A 511
ALA A 487
VAL A 501
None
1.01A 1xdkA-4di5A:
undetectable
1xdkA-4di5A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4heh APPA PROTEIN

(Rhodobacter
sphaeroides)
no annotation 5 ALA A 368
GLN A 369
ALA A 385
VAL A 281
LEU A 344
None
1.11A 1xdkA-4hehA:
undetectable
1xdkA-4hehA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iin 3-KETOACYL-ACYL
CARRIER PROTEIN
REDUCTASE (FABG)


(Helicobacter
pylori)
PF13561
(adh_short_C2)
5 ILE A  21
ASN A  35
LEU A  25
ALA A  26
VAL A 140
None
NAD  A 301 (-3.6A)
None
None
NAD  A 301 (-4.7A)
1.13A 1xdkA-4iinA:
undetectable
1xdkA-4iinA:
23.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4j5x RETINOIC ACID
RECEPTOR RXR-ALPHA,
NUCLEAR RECEPTOR
COACTIVATOR 1


(Homo sapiens)
no annotation 11 ILE D 268
ALA D 271
GLN D 275
TRP D 305
ASN D 306
PHE D 313
ARG D 316
ALA D 327
VAL D 342
CYH D 432
LEU D 436
None
0.71A 1xdkA-4j5xD:
34.1
1xdkA-4j5xD:
99.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4j5x RETINOIC ACID
RECEPTOR RXR-ALPHA,
NUCLEAR RECEPTOR
COACTIVATOR 1


(Homo sapiens)
no annotation 11 ILE D 268
ALA D 271
GLN D 275
TRP D 305
PHE D 313
ARG D 316
LEU D 326
ALA D 327
VAL D 342
CYH D 432
LEU D 436
None
0.60A 1xdkA-4j5xD:
34.1
1xdkA-4j5xD:
99.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6


(Homo sapiens)
PF00069
(Pkinase)
5 ILE A 503
GLN A 660
LEU A 631
VAL A 493
LEU A 667
None
1.03A 1xdkA-4ks8A:
undetectable
1xdkA-4ks8A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE


(Eggerthella
lenta)
PF00905
(Transpeptidase)
5 ALA A 251
GLN A 285
LEU A 284
ALA A 281
VAL A 217
None
1.10A 1xdkA-4mnrA:
undetectable
1xdkA-4mnrA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4na3 POLYKETIDE SYNTHASE
PKSJ


(Bacillus
subtilis)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc)
5 ILE A 585
ASN A 588
LEU A 563
ALA A 560
VAL A 461
None
1.12A 1xdkA-4na3A:
undetectable
1xdkA-4na3A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1u LYND

(Lyngbya
aestuarii)
PF02624
(YcaO)
5 ILE A 264
GLN A 258
LEU A 134
ALA A 133
VAL A 195
None
1.13A 1xdkA-4v1uA:
undetectable
1xdkA-4v1uA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w5k ASPARTATE
AMINOTRANSFERASE,
MITOCHONDRIAL


(Trypanosoma
brucei)
PF00155
(Aminotran_1_2)
5 ILE A 230
GLN A 233
LEU A 249
ALA A 248
VAL A 164
None
1.10A 1xdkA-4w5kA:
undetectable
1xdkA-4w5kA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ


(Escherichia
coli)
PF00588
(SpoU_methylase)
5 ALA A  53
LEU A  49
ALA A  50
VAL A  40
LEU A   9
None
1.00A 1xdkA-4xboA:
undetectable
1xdkA-4xboA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgj UNCHARACTERIZED
PROTEIN


(Pectobacterium
atrosepticum)
PF07005
(DUF1537)
PF17042
(DUF1357_C)
5 ILE A 211
ALA A 214
LEU A 183
ALA A 184
LEU A 230
None
1.01A 1xdkA-4xgjA:
undetectable
1xdkA-4xgjA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgj UNCHARACTERIZED
PROTEIN


(Pectobacterium
atrosepticum)
PF07005
(DUF1537)
PF17042
(DUF1357_C)
5 ILE A 350
ALA A 353
LEU A 299
VAL A 251
LEU A 386
None
1.02A 1xdkA-4xgjA:
undetectable
1xdkA-4xgjA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yk2 BARTONELLA EFFECTOR
PROTEIN (BEP)
SUBSTRATE OF VIRB
T4SS


(Bartonella
clarridgeiae)
no annotation 5 ILE A 160
ALA A 156
PHE A 103
LEU A 140
ALA A 141
None
0.88A 1xdkA-4yk2A:
undetectable
1xdkA-4yk2A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bxy RNA
METHYLTRANSFERASE


(Salinibacter
ruber)
PF13847
(Methyltransf_31)
5 ILE A  37
ALA A  41
ASN A  65
LEU A  27
ALA A  47
None
1.11A 1xdkA-5bxyA:
undetectable
1xdkA-5bxyA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dlq EXPORTIN-4

(Mus musculus)
no annotation 5 ILE B 987
ALA B 952
ASN B 960
LEU B 922
LEU B 998
None
1.12A 1xdkA-5dlqB:
undetectable
1xdkA-5dlqB:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5irm UNCHARACTERIZED
PROTEIN


(Oryctolagus
cuniculus)
PF05729
(NACHT)
PF13516
(LRR_6)
5 ALA A 900
GLN A 897
LEU A 927
ALA A 926
LEU A 871
None
1.14A 1xdkA-5irmA:
undetectable
1xdkA-5irmA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jo7 VETISPIRADIENE
SYNTHASE 1


(Hyoscyamus
muticus)
PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C)
5 ILE A 439
ALA A 442
ASN A 518
ALA A 494
VAL A 508
None
0.95A 1xdkA-5jo7A:
undetectable
1xdkA-5jo7A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l51 (-)-MENTHONE:(+)-NEO
MENTHOL REDUCTASE


(Mentha x
piperita)
PF00106
(adh_short)
PF13561
(adh_short_C2)
5 ILE A  29
ASN A  22
LEU A  33
ALA A  34
VAL A 186
None
0.79A 1xdkA-5l51A:
undetectable
1xdkA-5l51A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lcx (-)-ISOPIPERITENONE
REDUCTASE


(Mentha x
piperita)
PF00106
(adh_short)
5 ILE A  21
ASN A  14
LEU A  25
ALA A  26
VAL A 180
None
NAP  A 400 (-2.8A)
None
None
NAP  A 400 (-4.0A)
0.93A 1xdkA-5lcxA:
undetectable
1xdkA-5lcxA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lnq 3-KETOACYL-COA
THIOLASE-LIKE
PROTEIN


(Leishmania
mexicana)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
5 ALA A 142
GLN A  75
LEU A 137
ALA A 136
LEU A  66
None
1.06A 1xdkA-5lnqA:
undetectable
1xdkA-5lnqA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nzb PROFILIN-2

(Betula pendula)
no annotation 5 ILE A  27
ALA A 102
GLN A 101
LEU A 128
VAL A   7
None
1.09A 1xdkA-5nzbA:
undetectable
1xdkA-5nzbA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohs -

(-)
no annotation 5 ILE A 257
ALA A 260
PHE A 541
LEU A 538
ALA A 539
None
0.88A 1xdkA-5ohsA:
undetectable
1xdkA-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t1p ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN


(Campylobacter
jejuni)
PF13343
(SBP_bac_6)
5 ALA A 179
TRP A 328
LEU A 183
ALA A 182
LEU A 335
None
1.09A 1xdkA-5t1pA:
undetectable
1xdkA-5t1pA:
21.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uan RETINOIC ACID
RECEPTOR RXR-ALPHA


(Homo sapiens)
no annotation 12 ILE A 268
ALA A 271
GLN A 275
TRP A 305
ASN A 306
PHE A 313
ARG A 316
LEU A 326
ALA A 327
VAL A 342
CYH A 432
LEU A 436
9CR  A 503 (-4.0A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.8A)
None
None
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
None
9CR  A 503 (-3.3A)
9CR  A 503 ( 4.8A)
0.56A 1xdkA-5uanA:
34.4
1xdkA-5uanA:
99.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uro PREDICTED PROTEIN

(Trichoderma
reesei)
PF00561
(Abhydrolase_1)
5 ILE A 327
ASN A 332
ALA A 307
VAL A  40
LEU A  63
None
1.08A 1xdkA-5uroA:
undetectable
1xdkA-5uroA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vmk BIFUNCTIONAL PROTEIN
GLMU


(Acinetobacter
baumannii)
PF00132
(Hexapep)
PF12804
(NTP_transf_3)
PF14602
(Hexapep_2)
5 ASN A  47
LEU A   8
ALA A   9
VAL A 172
LEU A  90
None
1.10A 1xdkA-5vmkA:
undetectable
1xdkA-5vmkA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6o SERINE/THREONINE-PRO
TEIN KINASE MEC1


(Saccharomyces
cerevisiae)
no annotation 5 ALA C2271
ASN C2204
PHE C2189
LEU C2185
VAL C2239
None
1.13A 1xdkA-5x6oC:
undetectable
1xdkA-5x6oC:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA


(Komagataella
phaffii)
PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
5 ILE B 247
ALA B 229
LEU B 378
VAL B 277
LEU B 354
None
1.08A 1xdkA-5xogB:
undetectable
1xdkA-5xogB:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi RIBOSOMAL PROTEIN
S19E, PUTATIVE


(Trichomonas
vaginalis)
PF01090
(Ribosomal_S19e)
5 ILE T  68
ALA T  65
LEU T  25
ALA T  26
LEU T 111
None
0.98A 1xdkA-5xyiT:
undetectable
1xdkA-5xyiT:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z2g L-AMINO ACID OXIDASE

(Naja atra)
no annotation 5 ILE A 121
GLN A 261
ASN A 129
PHE A 259
LEU A 262
None
None
NAG  A 602 ( 4.4A)
None
None
1.03A 1xdkA-5z2gA:
undetectable
1xdkA-5z2gA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zya SPLICING FACTOR 3B
SUBUNIT 1


(Homo sapiens)
no annotation 5 ALA C 672
GLN C 669
LEU C 712
ALA C 711
CYH C 652
None
1.14A 1xdkA-5zyaC:
undetectable
1xdkA-5zyaC:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zya SPLICING FACTOR 3B
SUBUNIT 1


(Homo sapiens)
no annotation 5 ALA C 672
GLN C 669
LEU C 712
ALA C 711
LEU C 644
None
1.13A 1xdkA-5zyaC:
undetectable
1xdkA-5zyaC:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c66 CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY


(Thermobifida
fusca)
no annotation 5 ILE A  71
LEU A 273
ALA A 268
VAL A 182
LEU A  44
None
0.99A 1xdkA-6c66A:
undetectable
1xdkA-6c66A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6co9 PROBABLE
COA-TRANSFERASE
ALPHA SUBUNIT


(Rhodococcus
jostii)
no annotation 5 ALA A 168
LEU A 165
ALA A 198
VAL A  69
LEU A  42
None
1.14A 1xdkA-6co9A:
undetectable
1xdkA-6co9A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g96 ACETYLTRANSFERASE

(Salmonella
enterica)
no annotation 5 TRP B 142
LEU B 169
ALA B 168
VAL B  64
LEU B  95
ACO  B 201 ( 3.9A)
None
None
None
ACO  B 201 (-4.6A)
1.04A 1xdkA-6g96B:
undetectable
1xdkA-6g96B:
16.26