SIMILAR PATTERNS OF AMINO ACIDS FOR 1XDK_A_9CRA500
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bsg | BETA LACTAMASE (Streptomycesalbus) |
PF13354(Beta-lactamase2) | 5 | ALA A 280PHE A 221ALA A 223VAL A 57LEU A 44 | None | 1.05A | 1xdkA-1bsgA:undetectable | 1xdkA-1bsgA:22.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ci9 | PROTEIN(CARBOXYLESTERASE) (Burkholderiagladioli) |
PF00144(Beta-lactamase) | 5 | ALA A 306GLN A 310ALA A 305VAL A 192LEU A 185 | None | 1.12A | 1xdkA-1ci9A:undetectable | 1xdkA-1ci9A:20.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e19 | CARBAMATE KINASE (Pyrococcusfuriosus) |
PF00696(AA_kinase) | 6 | ILE A 37ALA A 34LEU A 97ALA A 96VAL A 5LEU A 234 | None | 0.90A | 1xdkA-1e19A:undetectable | 1xdkA-1e19A:22.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1faf | LARGE T ANTIGEN (Mus musculuspolyomavirus 1) |
no annotation | 5 | ALA A 33GLN A 37ASN A 56LEU A 19VAL A 66 | None | 1.03A | 1xdkA-1fafA:undetectable | 1xdkA-1fafA:15.74 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hg4 | ULTRASPIRACLE (Drosophilamelanogaster) |
PF00104(Hormone_recep) | 5 | TRP A 318LEU A 366VAL A 382CYH A 472LEU A 476 | NoneLPP A 1 ( 4.4A)LPP A 1 (-4.8A)LPP A 1 ( 4.2A)LPP A 1 (-4.2A) | 0.71A | 1xdkA-1hg4A:24.7 | 1xdkA-1hg4A:43.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mg5 | ALCOHOLDEHYDROGENASE (Drosophilamelanogaster) |
PF00106(adh_short) | 5 | ILE A 226ALA A 225ASN A 136PHE A 222VAL A 9 | None | 1.11A | 1xdkA-1mg5A:undetectable | 1xdkA-1mg5A:23.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n4d | VITAMIN B12TRANSPORT PROTEINBTUF (Escherichiacoli) |
PF01497(Peripla_BP_2) | 5 | ILE A 90ALA A 94LEU A 117ALA A 114VAL A 160 | None | 1.10A | 1xdkA-1n4dA:undetectable | 1xdkA-1n4dA:24.65 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1r20 | ULTRASPIRACLEPROTEIN (Heliothisvirescens) |
PF00104(Hormone_recep) | 5 | TRP A 286ARG A 297LEU A 325VAL A 341LEU A 435 | NoneNoneNoneEPH A4000 (-4.9A)EPH A4000 ( 4.6A) | 0.73A | 1xdkA-1r20A:24.4 | 1xdkA-1r20A:45.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sjp | 60 KDA CHAPERONIN 2 (Mycobacteriumtuberculosis) |
PF00118(Cpn60_TCP1) | 5 | ASN A 262PHE A 201ALA A 210VAL A 224LEU A 234 | None | 1.06A | 1xdkA-1sjpA:undetectable | 1xdkA-1sjpA:20.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sjp | 60 KDA CHAPERONIN 2 (Mycobacteriumtuberculosis) |
PF00118(Cpn60_TCP1) | 5 | ILE A 246ASN A 262PHE A 201VAL A 224LEU A 234 | None | 0.87A | 1xdkA-1sjpA:undetectable | 1xdkA-1sjpA:20.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1srv | PROTEIN (GROEL(HSP60 CLASS)) (Thermusthermophilus) |
PF00118(Cpn60_TCP1) | 5 | ASN A 265PHE A 204ALA A 213VAL A 227LEU A 237 | None | 1.00A | 1xdkA-1srvA:undetectable | 1xdkA-1srvA:22.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1srv | PROTEIN (GROEL(HSP60 CLASS)) (Thermusthermophilus) |
PF00118(Cpn60_TCP1) | 5 | ILE A 249ASN A 265PHE A 204VAL A 227LEU A 237 | None | 0.88A | 1xdkA-1srvA:undetectable | 1xdkA-1srvA:22.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tf1 | NEGATIVE REGULATOROF ALLANTOIN ANDGLYOXYLATEUTILIZATION OPERONS (Escherichiacoli) |
PF01614(IclR) | 5 | ILE A 36ALA A 147LEU A 75ALA A 74LEU A 14 | None | 1.14A | 1xdkA-1tf1A:undetectable | 1xdkA-1tf1A:23.32 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1uhl | RETINOIC ACIDRECEPTOR RXR-BETA (Homo sapiens) |
PF00104(Hormone_recep) | 12 | ILE A 339ALA A 342GLN A 346TRP A 376ASN A 377PHE A 384ARG A 387LEU A 397ALA A 398VAL A 413CYH A 503LEU A 507 | MEI A1001 (-3.8A)MEI A1001 (-3.1A)NoneNoneNoneMEI A1001 (-4.5A)MEI A1001 (-3.6A)MEI A1001 ( 4.4A)MEI A1001 (-3.4A)MEI A1001 (-4.1A)MEI A1001 (-4.0A)MEI A1001 (-4.6A) | 0.61A | 1xdkA-1uhlA:35.2 | 1xdkA-1uhlA:87.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x3l | HYPOTHETICAL PROTEINPH0495 (Pyrococcushorikoshii) |
PF05161(MOFRL)PF13660(DUF4147) | 5 | ALA A 55LEU A 128ALA A 64VAL A 260LEU A 116 | NoneNoneNoneEDO A 502 (-4.3A)None | 1.13A | 1xdkA-1x3lA:undetectable | 1xdkA-1x3lA:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x3l | HYPOTHETICAL PROTEINPH0495 (Pyrococcushorikoshii) |
PF05161(MOFRL)PF13660(DUF4147) | 5 | ILE A 67ALA A 64ALA A 55VAL A 33LEU A 28 | None | 1.14A | 1xdkA-1x3lA:undetectable | 1xdkA-1x3lA:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x3l | HYPOTHETICAL PROTEINPH0495 (Pyrococcushorikoshii) |
PF05161(MOFRL)PF13660(DUF4147) | 5 | ILE A 127ALA A 55ALA A 64VAL A 260LEU A 116 | NoneNoneNoneEDO A 502 (-4.3A)None | 1.10A | 1xdkA-1x3lA:undetectable | 1xdkA-1x3lA:21.04 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1xiu | RXR-LIKE PROTEIN (Biomphalariaglabrata) |
PF00104(Hormone_recep) | 12 | ILE A 242ALA A 245GLN A 249TRP A 279ASN A 280PHE A 287ARG A 290LEU A 300ALA A 301VAL A 316CYH A 406LEU A 410 | 9CR A 201 ( 4.4A)9CR A 201 (-3.6A)9CR A 201 (-4.1A)NoneNone9CR A 201 (-4.7A)9CR A 201 (-2.8A)9CR A 201 (-4.4A)9CR A 201 (-3.4A)9CR A 201 (-4.2A)9CR A 201 (-3.6A)9CR A 201 ( 4.8A) | 0.46A | 1xdkA-1xiuA:31.6 | 1xdkA-1xiuA:81.51 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1xls | RETINOIC ACIDRECEPTOR RXR-ALPHA (Homo sapiens) |
PF00104(Hormone_recep) | 12 | ILE A 268ALA A 271GLN A 275TRP A 305ASN A 306PHE A 313ARG A 316LEU A 326ALA A 327VAL A 342CYH A 432LEU A 436 | 9CR A 801 (-3.9A)9CR A 801 (-3.6A)9CR A 801 (-4.7A)NoneNone9CR A 801 (-4.3A)9CR A 801 (-2.6A)9CR A 801 (-4.1A)9CR A 801 (-3.3A)9CR A 801 ( 4.3A)9CR A 801 ( 3.7A)9CR A 801 (-4.7A) | 0.40A | 1xdkA-1xlsA:34.9 | 1xdkA-1xlsA:99.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ykw | RUBISCO-LIKE PROTEIN (Chlorobaculumtepidum) |
PF00016(RuBisCO_large)PF02788(RuBisCO_large_N) | 5 | ILE A 239ALA A 253ALA A 215VAL A 268LEU A 284 | None | 1.13A | 1xdkA-1ykwA:undetectable | 1xdkA-1ykwA:21.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z69 | COENZYMEF420-DEPENDENTN(5),N(10)-METHYLENETETRAHYDROMETHANOPTERIN REDUCTASE (Methanosarcinabarkeri) |
PF00296(Bac_luciferase) | 5 | ILE A 258ALA A 257PHE A 263LEU A 266ALA A 265 | None | 1.05A | 1xdkA-1z69A:undetectable | 1xdkA-1z69A:21.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ayx | SENSOR KINASEPROTEIN RCSC (Escherichiacoli) |
PF00072(Response_reg)PF09456(RcsC) | 5 | ALA A 787ARG A 767LEU A 718ALA A 786VAL A 746 | None | 1.03A | 1xdkA-2ayxA:undetectable | 1xdkA-2ayxA:21.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dpl | GMP SYNTHASE[GLUTAMINE-HYDROLYZING] SUBUNIT B (Pyrococcushorikoshii) |
PF00958(GMP_synt_C)PF02540(NAD_synthase) | 5 | ASN A 54PHE A 88LEU A 91ALA A 90VAL A 209 | None | 1.14A | 1xdkA-2dplA:undetectable | 1xdkA-2dplA:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fv2 | RCD1 REQUIRED FORCELLDIFFERENTIATION1HOMOLOG (Homo sapiens) |
PF04078(Rcd1) | 5 | ALA A 85GLN A 82LEU A 130ALA A 129LEU A 51 | None | 0.82A | 1xdkA-2fv2A:undetectable | 1xdkA-2fv2A:24.57 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2gl8 | RETINOIC ACIDRECEPTOR RXR-GAMMA (Homo sapiens) |
PF00104(Hormone_recep) | 7 | TRP A 84PHE A 92ARG A 95LEU A 105ALA A 106VAL A 121CYH A 211 | None | 0.78A | 1xdkA-2gl8A:27.0 | 1xdkA-2gl8A:85.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hxo | PUTATIVE TETR-FAMILYTRANSCRIPTIONALREGULATOR (Streptomycescoelicolor) |
PF00440(TetR_N)PF02909(TetR_C) | 5 | PHE A 217LEU A 218ALA A 219VAL A 75LEU A 131 | None | 1.07A | 1xdkA-2hxoA:undetectable | 1xdkA-2hxoA:23.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ix5 | ACYL-COENZYME AOXIDASE 4,PEROXISOMAL (Arabidopsisthaliana) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 5 | ALA A 101LEU A 166ALA A 164VAL A 74CYH A 69 | None | 1.01A | 1xdkA-2ix5A:undetectable | 1xdkA-2ix5A:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2mqa | MINOR AMPULLATEFIBROIN 1 (Nephilaantipodiana) |
PF12042(RP1-2) | 5 | ILE A 101ASN A 95LEU A 105ALA A 106VAL A 54 | None | 1.14A | 1xdkA-2mqaA:undetectable | 1xdkA-2mqaA:18.26 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2nxx | ULTRASPIRACLE (USP,NR2B4) (Triboliumcastaneum) |
PF00104(Hormone_recep) | 5 | PHE A 259ARG A 262LEU A 272ALA A 273CYH A 378 | None | 0.77A | 1xdkA-2nxxA:24.6 | 1xdkA-2nxxA:62.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o6i | HD DOMAIN PROTEIN (Enterococcusfaecalis) |
PF01966(HD) | 5 | ALA A 332ASN A 365PHE A 334LEU A 452ALA A 451 | None | 1.14A | 1xdkA-2o6iA:undetectable | 1xdkA-2o6iA:19.71 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2q60 | RETINOID X RECEPTOR (Polyandrocarpamisakiensis) |
PF00104(Hormone_recep) | 7 | TRP A 180ASN A 181PHE A 188ARG A 191ALA A 202VAL A 217CYH A 307 | None | 0.53A | 1xdkA-2q60A:26.9 | 1xdkA-2q60A:72.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q8w | POKEWEED ANTIVIRALPROTEIN (Phytolaccaacinosa) |
PF00161(RIP) | 5 | ILE A 214ALA A 217ARG A 240LEU A 222ALA A 221 | None | 0.98A | 1xdkA-2q8wA:undetectable | 1xdkA-2q8wA:22.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qde | MANDELATERACEMASE/MUCONATELACTONIZING ENZYMEFAMILY PROTEIN (Aromatoleumaromaticum) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ILE A 69ALA A 103GLN A 102VAL A 387LEU A 38 | None | 1.12A | 1xdkA-2qdeA:undetectable | 1xdkA-2qdeA:23.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qes | RIBOSOME-INACTIVATING PROTEIN PD-L4 (Phytolaccadioica) |
PF00161(RIP) | 5 | ILE A 214ALA A 217ARG A 240LEU A 222ALA A 221 | None | 1.09A | 1xdkA-2qesA:undetectable | 1xdkA-2qesA:22.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2uv8 | FATTY ACID SYNTHASESUBUNIT BETA (FAS1) (Saccharomycescerevisiae) |
PF00698(Acyl_transf_1)PF01575(MaoC_dehydratas)PF08354(DUF1729)PF13452(MaoC_dehydrat_N)PF16073(SAT) | 5 | ILE G 283LEU G 246ALA G 247VAL G 459LEU G 267 | None | 1.13A | 1xdkA-2uv8G:undetectable | 1xdkA-2uv8G:8.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wkn | FORMAMIDASE (Delftiaacidovorans) |
PF03069(FmdA_AmdA) | 5 | ALA A 244TRP A 24PHE A 237LEU A 87VAL A 272 | None | 1.12A | 1xdkA-2wknA:undetectable | 1xdkA-2wknA:20.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x0f | WSAF (Geobacillusstearothermophilus) |
no annotation | 5 | ILE A 137GLN A 148ASN A 163ALA A 144LEU A 413 | None | 1.05A | 1xdkA-2x0fA:undetectable | 1xdkA-2x0fA:20.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xgo | XCOGT (Xanthomonascampestris) |
PF13432(TPR_16)PF13844(Glyco_transf_41) | 5 | ALA A 549PHE A 228LEU A 231ALA A 230LEU A 328 | None | 1.03A | 1xdkA-2xgoA:undetectable | 1xdkA-2xgoA:18.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3am6 | RHODOPSIN-2 (Acetabulariaacetabulum) |
PF01036(Bac_rhodopsin) | 5 | ILE A 44ALA A 47VAL A 95CYH A 218LEU A 219 | NoneNoneNoneNoneCLR A 401 ( 4.6A) | 1.01A | 1xdkA-3am6A:undetectable | 1xdkA-3am6A:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b89 | 16S RRNA METHYLASE (Escherichiacoli) |
PF07091(FmrO) | 5 | ALA A 77LEU A 69ALA A 68VAL A 127CYH A 112 | None | 1.09A | 1xdkA-3b89A:undetectable | 1xdkA-3b89A:24.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ci0 | PSEUDOPILIN GSPK (Escherichiacoli) |
PF03934(T2SSK) | 5 | ILE K 218ALA K 221LEU K 119ALA K 118LEU K 271 | None | 0.99A | 1xdkA-3ci0K:undetectable | 1xdkA-3ci0K:23.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dh4 | SODIUM/GLUCOSECOTRANSPORTER (Vibrioparahaemolyticus) |
PF00474(SSF) | 5 | ILE A 287ALA A 291ASN A 525LEU A 95ALA A 92 | None | 1.07A | 1xdkA-3dh4A:undetectable | 1xdkA-3dh4A:19.15 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3dzu | RETINOIC ACIDRECEPTOR RXR-ALPHA (Homo sapiens) |
PF00104(Hormone_recep)PF00105(zf-C4) | 10 | ILE A 268ALA A 271GLN A 275TRP A 305ASN A 306PHE A 313ARG A 316LEU A 326VAL A 342LEU A 436 | 9CR A7223 (-3.9A)9CR A7223 (-3.5A)9CR A7223 (-4.6A)None9CR A7223 (-3.9A)9CR A7223 (-4.5A)9CR A7223 (-3.7A)9CR A7223 (-3.8A)9CR A7223 ( 4.5A)9CR A7223 ( 4.7A) | 0.76A | 1xdkA-3dzuA:33.7 | 1xdkA-3dzuA:99.16 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3dzu | RETINOIC ACIDRECEPTOR RXR-ALPHA (Homo sapiens) |
PF00104(Hormone_recep)PF00105(zf-C4) | 11 | ILE A 268ALA A 271GLN A 275TRP A 305PHE A 313ARG A 316LEU A 326ALA A 327VAL A 342CYH A 432LEU A 436 | 9CR A7223 (-3.9A)9CR A7223 (-3.5A)9CR A7223 (-4.6A)None9CR A7223 (-4.5A)9CR A7223 (-3.7A)9CR A7223 (-3.8A)9CR A7223 ( 4.7A)9CR A7223 ( 4.5A)9CR A7223 (-3.8A)9CR A7223 ( 4.7A) | 0.70A | 1xdkA-3dzuA:33.7 | 1xdkA-3dzuA:99.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ejb | BIOTIN BIOSYNTHESISCYTOCHROME P450-LIKEENZYME (Bacillussubtilis) |
PF00067(p450) | 5 | ILE B 358ALA B 270ASN B 245LEU B 260LEU B 242 | NoneNoneNoneNoneHEM B 405 ( 4.5A) | 1.13A | 1xdkA-3ejbB:undetectable | 1xdkA-3ejbB:23.04 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3eyb | NUCLEAR HORMONERECEPTOR RXR (Branchiostomafloridae) |
PF00104(Hormone_recep) | 6 | ASN A 335PHE A 342LEU A 355ALA A 356VAL A 371CYH A 461 | None | 0.90A | 1xdkA-3eybA:28.1 | 1xdkA-3eybA:84.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h5k | RIBOSOME-INACTIVATING PROTEINPD-L1/PD-L2 (Phytolaccadioica) |
PF00161(RIP) | 5 | ILE A 214ALA A 217ARG A 240LEU A 222ALA A 221 | None | 0.96A | 1xdkA-3h5kA:undetectable | 1xdkA-3h5kA:19.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hve | GIGAXONIN (Homo sapiens) |
PF00651(BTB)PF07707(BACK) | 5 | ILE A 47ALA A 50LEU B 20ALA B 19LEU A 87 | None | 0.69A | 1xdkA-3hveA:undetectable | 1xdkA-3hveA:21.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hve | GIGAXONIN (Homo sapiens) |
PF00651(BTB)PF07707(BACK) | 5 | ILE B 47ALA B 50LEU A 20ALA A 19LEU B 87 | None | 0.91A | 1xdkA-3hveB:undetectable | 1xdkA-3hveB:18.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iiw | POLYCOMB PROTEIN EED (Homo sapiens) |
PF00400(WD40) | 5 | ILE A 172ALA A 164ASN A 219LEU A 196ALA A 151 | None | 1.13A | 1xdkA-3iiwA:undetectable | 1xdkA-3iiwA:20.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iv0 | SUSD HOMOLOG (Bacteroidesthetaiotaomicron) |
PF07980(SusD_RagB)PF14322(SusD-like_3) | 5 | ILE A 121ALA A 124ASN A 172ALA A 149VAL A 167 | None | 1.11A | 1xdkA-3iv0A:undetectable | 1xdkA-3iv0A:20.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jb9 | PRE-MRNA-SPLICINGFACTOR CWF5 (Schizosaccharomycespombe) |
PF08082(PRO8NT)PF08083(PROCN)PF10596(U6-snRNA_bdg)PF10597(U5_2-snRNA_bdg)PF10598(RRM_4)PF12134(PRP8_domainIV) | 5 | ILE a 46ALA a 117GLN a 120ASN a 78CYH a 79 | None | 1.13A | 1xdkA-3jb9a:undetectable | 1xdkA-3jb9a:17.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ktc | XYLOSE ISOMERASE (Pectobacteriumatrosepticum) |
PF01261(AP_endonuc_2) | 5 | ILE A 292ALA A 295LEU A 324ALA A 323VAL A 230 | None | 0.94A | 1xdkA-3ktcA:undetectable | 1xdkA-3ktcA:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l0g | NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE (Ehrlichiachaffeensis) |
PF01729(QRPTase_C)PF02749(QRPTase_N) | 5 | ILE A 94LEU A 13ALA A 12VAL A 63LEU A 271 | None | 1.07A | 1xdkA-3l0gA:undetectable | 1xdkA-3l0gA:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l6a | EUKARYOTICTRANSLATIONINITIATION FACTOR 4GAMMA 2 (Homo sapiens) |
PF02020(W2)PF02847(MA3) | 5 | ALA A 111GLN A 143LEU A 144VAL A 162LEU A 128 | NoneNoneNoneMES A 361 (-3.6A)None | 1.03A | 1xdkA-3l6aA:undetectable | 1xdkA-3l6aA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n0u | PROBABLEN-GLYCOSYLASE/DNALYASE (Thermotogamaritima) |
no annotation | 5 | ALA A 91GLN A 88ARG A 80LEU A 79ALA A 76 | None | 1.07A | 1xdkA-3n0uA:undetectable | 1xdkA-3n0uA:22.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r3h | O-METHYLTRANSFERASE,SAM-DEPENDENT (Legionellapneumophila) |
PF01596(Methyltransf_3) | 5 | ILE A 142ALA A 144LEU A 67VAL A 217LEU A 193 | None | 1.14A | 1xdkA-3r3hA:undetectable | 1xdkA-3r3hA:22.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rj9 | ALCOHOLDEHYDROGENASE (Scaptodrosophilalebanonensis) |
PF00106(adh_short) | 5 | ILE A 225ALA A 224ASN A 135PHE A 221VAL A 8 | None | 1.13A | 1xdkA-3rj9A:undetectable | 1xdkA-3rj9A:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rko | NADH-QUINONEOXIDOREDUCTASESUBUNIT N (Escherichiacoli) |
no annotation | 5 | ILE N 250ALA N 249LEU N 119ALA N 120LEU N 306 | None | 0.91A | 1xdkA-3rkoN:undetectable | 1xdkA-3rkoN:19.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rmj | 2-ISOPROPYLMALATESYNTHASE (Neisseriameningitidis) |
PF00682(HMGL-like) | 6 | ILE A 156ALA A 159TRP A 201PHE A 140ALA A 163LEU A 189 | None | 1.32A | 1xdkA-3rmjA:undetectable | 1xdkA-3rmjA:22.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ttf | TRANSCRIPTIONALREGULATORY PROTEIN (Escherichiacoli) |
PF01300(Sua5_yciO_yrdC)PF07503(zf-HYPF) | 5 | ALA A 602LEU A 622ALA A 618VAL A 636LEU A 655 | None | 1.01A | 1xdkA-3ttfA:undetectable | 1xdkA-3ttfA:18.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uc2 | HYPOTHETICAL PROTEINWITHIMMUNOGLOBULIN-LIKEFOLD (Pseudomonasaeruginosa) |
PF14467(DUF4426) | 5 | ILE A 59ALA A 103GLN A 104PHE A 105LEU A 88 | None | 1.03A | 1xdkA-3uc2A:undetectable | 1xdkA-3uc2A:20.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3up4 | OTEMO (Pseudomonasputida) |
PF00743(FMO-like) | 5 | ILE A 201ALA A 204ASN A 343LEU A 211ALA A 208 | None | 1.11A | 1xdkA-3up4A:undetectable | 1xdkA-3up4A:18.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zil | AAR187CP (Eremotheciumgossypii) |
PF16997(Wap1) | 6 | ILE A 359ALA A 356TRP A 338LEU A 397ALA A 393LEU A 335 | None | 1.41A | 1xdkA-3zilA:undetectable | 1xdkA-3zilA:20.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4di5 | 5-EPI-ARISTOLOCHENESYNTHASE (Nicotianatabacum) |
PF01397(Terpene_synth)PF03936(Terpene_synth_C) | 5 | ILE A 432ALA A 435ASN A 511ALA A 487VAL A 501 | None | 1.01A | 1xdkA-4di5A:undetectable | 1xdkA-4di5A:19.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4heh | APPA PROTEIN (Rhodobactersphaeroides) |
no annotation | 5 | ALA A 368GLN A 369ALA A 385VAL A 281LEU A 344 | None | 1.11A | 1xdkA-4hehA:undetectable | 1xdkA-4hehA:23.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iin | 3-KETOACYL-ACYLCARRIER PROTEINREDUCTASE (FABG) (Helicobacterpylori) |
PF13561(adh_short_C2) | 5 | ILE A 21ASN A 35LEU A 25ALA A 26VAL A 140 | NoneNAD A 301 (-3.6A)NoneNoneNAD A 301 (-4.7A) | 1.13A | 1xdkA-4iinA:undetectable | 1xdkA-4iinA:23.13 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4j5x | RETINOIC ACIDRECEPTOR RXR-ALPHA,NUCLEAR RECEPTORCOACTIVATOR 1 (Homo sapiens) |
no annotation | 11 | ILE D 268ALA D 271GLN D 275TRP D 305ASN D 306PHE D 313ARG D 316ALA D 327VAL D 342CYH D 432LEU D 436 | None | 0.71A | 1xdkA-4j5xD:34.1 | 1xdkA-4j5xD:99.15 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4j5x | RETINOIC ACIDRECEPTOR RXR-ALPHA,NUCLEAR RECEPTORCOACTIVATOR 1 (Homo sapiens) |
no annotation | 11 | ILE D 268ALA D 271GLN D 275TRP D 305PHE D 313ARG D 316LEU D 326ALA D 327VAL D 342CYH D 432LEU D 436 | None | 0.60A | 1xdkA-4j5xD:34.1 | 1xdkA-4j5xD:99.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ks8 | SERINE/THREONINE-PROTEIN KINASE PAK 6 (Homo sapiens) |
PF00069(Pkinase) | 5 | ILE A 503GLN A 660LEU A 631VAL A 493LEU A 667 | None | 1.03A | 1xdkA-4ks8A:undetectable | 1xdkA-4ks8A:23.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mnr | PEPTIDOGLYCANGLYCOSYLTRANSFERASE (Eggerthellalenta) |
PF00905(Transpeptidase) | 5 | ALA A 251GLN A 285LEU A 284ALA A 281VAL A 217 | None | 1.10A | 1xdkA-4mnrA:undetectable | 1xdkA-4mnrA:20.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4na3 | POLYKETIDE SYNTHASEPKSJ (Bacillussubtilis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C)PF16197(KAsynt_C_assoc) | 5 | ILE A 585ASN A 588LEU A 563ALA A 560VAL A 461 | None | 1.12A | 1xdkA-4na3A:undetectable | 1xdkA-4na3A:18.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4v1u | LYND (Lyngbyaaestuarii) |
PF02624(YcaO) | 5 | ILE A 264GLN A 258LEU A 134ALA A 133VAL A 195 | None | 1.13A | 1xdkA-4v1uA:undetectable | 1xdkA-4v1uA:16.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4w5k | ASPARTATEAMINOTRANSFERASE,MITOCHONDRIAL (Trypanosomabrucei) |
PF00155(Aminotran_1_2) | 5 | ILE A 230GLN A 233LEU A 249ALA A 248VAL A 164 | None | 1.10A | 1xdkA-4w5kA:undetectable | 1xdkA-4w5kA:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xbo | TRNA(CYTIDINE/URIDINE-2'-O-)-METHYLTRANSFERASE TRMJ (Escherichiacoli) |
PF00588(SpoU_methylase) | 5 | ALA A 53LEU A 49ALA A 50VAL A 40LEU A 9 | None | 1.00A | 1xdkA-4xboA:undetectable | 1xdkA-4xboA:23.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xgj | UNCHARACTERIZEDPROTEIN (Pectobacteriumatrosepticum) |
PF07005(DUF1537)PF17042(DUF1357_C) | 5 | ILE A 211ALA A 214LEU A 183ALA A 184LEU A 230 | None | 1.01A | 1xdkA-4xgjA:undetectable | 1xdkA-4xgjA:19.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xgj | UNCHARACTERIZEDPROTEIN (Pectobacteriumatrosepticum) |
PF07005(DUF1537)PF17042(DUF1357_C) | 5 | ILE A 350ALA A 353LEU A 299VAL A 251LEU A 386 | None | 1.02A | 1xdkA-4xgjA:undetectable | 1xdkA-4xgjA:19.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yk2 | BARTONELLA EFFECTORPROTEIN (BEP)SUBSTRATE OF VIRBT4SS (Bartonellaclarridgeiae) |
no annotation | 5 | ILE A 160ALA A 156PHE A 103LEU A 140ALA A 141 | None | 0.88A | 1xdkA-4yk2A:undetectable | 1xdkA-4yk2A:20.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bxy | RNAMETHYLTRANSFERASE (Salinibacterruber) |
PF13847(Methyltransf_31) | 5 | ILE A 37ALA A 41ASN A 65LEU A 27ALA A 47 | None | 1.11A | 1xdkA-5bxyA:undetectable | 1xdkA-5bxyA:23.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dlq | EXPORTIN-4 (Mus musculus) |
no annotation | 5 | ILE B 987ALA B 952ASN B 960LEU B 922LEU B 998 | None | 1.12A | 1xdkA-5dlqB:undetectable | 1xdkA-5dlqB:12.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5irm | UNCHARACTERIZEDPROTEIN (Oryctolaguscuniculus) |
PF05729(NACHT)PF13516(LRR_6) | 5 | ALA A 900GLN A 897LEU A 927ALA A 926LEU A 871 | None | 1.14A | 1xdkA-5irmA:undetectable | 1xdkA-5irmA:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jo7 | VETISPIRADIENESYNTHASE 1 (Hyoscyamusmuticus) |
PF01397(Terpene_synth)PF03936(Terpene_synth_C) | 5 | ILE A 439ALA A 442ASN A 518ALA A 494VAL A 508 | None | 0.95A | 1xdkA-5jo7A:undetectable | 1xdkA-5jo7A:18.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l51 | (-)-MENTHONE:(+)-NEOMENTHOL REDUCTASE (Mentha xpiperita) |
PF00106(adh_short)PF13561(adh_short_C2) | 5 | ILE A 29ASN A 22LEU A 33ALA A 34VAL A 186 | None | 0.79A | 1xdkA-5l51A:undetectable | 1xdkA-5l51A:22.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lcx | (-)-ISOPIPERITENONEREDUCTASE (Mentha xpiperita) |
PF00106(adh_short) | 5 | ILE A 21ASN A 14LEU A 25ALA A 26VAL A 180 | NoneNAP A 400 (-2.8A)NoneNoneNAP A 400 (-4.0A) | 0.93A | 1xdkA-5lcxA:undetectable | 1xdkA-5lcxA:24.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lnq | 3-KETOACYL-COATHIOLASE-LIKEPROTEIN (Leishmaniamexicana) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 5 | ALA A 142GLN A 75LEU A 137ALA A 136LEU A 66 | None | 1.06A | 1xdkA-5lnqA:undetectable | 1xdkA-5lnqA:19.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nzb | PROFILIN-2 (Betula pendula) |
no annotation | 5 | ILE A 27ALA A 102GLN A 101LEU A 128VAL A 7 | None | 1.09A | 1xdkA-5nzbA:undetectable | 1xdkA-5nzbA:18.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ohs | - (-) |
no annotation | 5 | ILE A 257ALA A 260PHE A 541LEU A 538ALA A 539 | None | 0.88A | 1xdkA-5ohsA:undetectable | 1xdkA-5ohsA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t1p | ABC TRANSPORTER,PERIPLASMICSUBSTRATE-BINDINGPROTEIN (Campylobacterjejuni) |
PF13343(SBP_bac_6) | 5 | ALA A 179TRP A 328LEU A 183ALA A 182LEU A 335 | None | 1.09A | 1xdkA-5t1pA:undetectable | 1xdkA-5t1pA:21.23 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5uan | RETINOIC ACIDRECEPTOR RXR-ALPHA (Homo sapiens) |
no annotation | 12 | ILE A 268ALA A 271GLN A 275TRP A 305ASN A 306PHE A 313ARG A 316LEU A 326ALA A 327VAL A 342CYH A 432LEU A 436 | 9CR A 503 (-4.0A)9CR A 503 (-3.5A)9CR A 503 (-3.8A)NoneNone9CR A 503 (-4.7A)9CR A 503 (-3.0A)9CR A 503 (-4.3A)9CR A 503 (-3.4A)None9CR A 503 (-3.3A)9CR A 503 ( 4.8A) | 0.56A | 1xdkA-5uanA:34.4 | 1xdkA-5uanA:99.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uro | PREDICTED PROTEIN (Trichodermareesei) |
PF00561(Abhydrolase_1) | 5 | ILE A 327ASN A 332ALA A 307VAL A 40LEU A 63 | None | 1.08A | 1xdkA-5uroA:undetectable | 1xdkA-5uroA:23.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vmk | BIFUNCTIONAL PROTEINGLMU (Acinetobacterbaumannii) |
PF00132(Hexapep)PF12804(NTP_transf_3)PF14602(Hexapep_2) | 5 | ASN A 47LEU A 8ALA A 9VAL A 172LEU A 90 | None | 1.10A | 1xdkA-5vmkA:undetectable | 1xdkA-5vmkA:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x6o | SERINE/THREONINE-PROTEIN KINASE MEC1 (Saccharomycescerevisiae) |
no annotation | 5 | ALA C2271ASN C2204PHE C2189LEU C2185VAL C2239 | None | 1.13A | 1xdkA-5x6oC:undetectable | 1xdkA-5x6oC:17.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xog | DNA-DIRECTED RNAPOLYMERASE SUBUNITBETA (Komagataellaphaffii) |
PF00562(RNA_pol_Rpb2_6)PF04560(RNA_pol_Rpb2_7)PF04561(RNA_pol_Rpb2_2)PF04563(RNA_pol_Rpb2_1)PF04565(RNA_pol_Rpb2_3)PF04566(RNA_pol_Rpb2_4)PF04567(RNA_pol_Rpb2_5) | 5 | ILE B 247ALA B 229LEU B 378VAL B 277LEU B 354 | None | 1.08A | 1xdkA-5xogB:undetectable | 1xdkA-5xogB:11.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xyi | RIBOSOMAL PROTEINS19E, PUTATIVE (Trichomonasvaginalis) |
PF01090(Ribosomal_S19e) | 5 | ILE T 68ALA T 65LEU T 25ALA T 26LEU T 111 | None | 0.98A | 1xdkA-5xyiT:undetectable | 1xdkA-5xyiT:19.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5z2g | L-AMINO ACID OXIDASE (Naja atra) |
no annotation | 5 | ILE A 121GLN A 261ASN A 129PHE A 259LEU A 262 | NoneNoneNAG A 602 ( 4.4A)NoneNone | 1.03A | 1xdkA-5z2gA:undetectable | 1xdkA-5z2gA:17.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zya | SPLICING FACTOR 3BSUBUNIT 1 (Homo sapiens) |
no annotation | 5 | ALA C 672GLN C 669LEU C 712ALA C 711CYH C 652 | None | 1.14A | 1xdkA-5zyaC:undetectable | 1xdkA-5zyaC:15.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zya | SPLICING FACTOR 3BSUBUNIT 1 (Homo sapiens) |
no annotation | 5 | ALA C 672GLN C 669LEU C 712ALA C 711LEU C 644 | None | 1.13A | 1xdkA-5zyaC:undetectable | 1xdkA-5zyaC:15.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c66 | CRISPR-ASSOCIATEDPROTEIN, CSE1 FAMILY (Thermobifidafusca) |
no annotation | 5 | ILE A 71LEU A 273ALA A 268VAL A 182LEU A 44 | None | 0.99A | 1xdkA-6c66A:undetectable | 1xdkA-6c66A:21.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6co9 | PROBABLECOA-TRANSFERASEALPHA SUBUNIT (Rhodococcusjostii) |
no annotation | 5 | ALA A 168LEU A 165ALA A 198VAL A 69LEU A 42 | None | 1.14A | 1xdkA-6co9A:undetectable | 1xdkA-6co9A:18.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6g96 | ACETYLTRANSFERASE (Salmonellaenterica) |
no annotation | 5 | TRP B 142LEU B 169ALA B 168VAL B 64LEU B 95 | ACO B 201 ( 3.9A)NoneNoneNoneACO B 201 (-4.6A) | 1.04A | 1xdkA-6g96B:undetectable | 1xdkA-6g96B:16.26 |