SIMILAR PATTERNS OF AMINO ACIDS FOR 1XBB_A_STIA1_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  78
VAL A  86
ALA A  99
GLY A 153
LEU A 201
 ATP  A 535 (-3.9A)
ATP  A 535 (-4.1A)
ATP  A 535 (-3.6A)
ATP  A 535 ( 4.7A)
ATP  A 535 (-4.8A)
 0.50A 1xbbA-1s9iA:
7.1		 1xbbA-1s9iA:
26.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 367
MET A 414
MET A 416
ALA A 417
GLY A 419
LEU A 468
 STU  A 100 (-3.2A)
STU  A 100 (-3.6A)
STU  A 100 (-3.8A)
STU  A 100 (-3.7A)
None
STU  A 100 (-4.5A)
 1.19A 1xbbA-1u59A:
40.0		 1xbbA-1u59A:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 344
VAL A 352
ALA A 367
MET A 414
MET A 416
ALA A 417
GLY A 420
PRO A 421
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
STU  A 100 (-3.6A)
STU  A 100 (-3.8A)
STU  A 100 (-3.7A)
STU  A 100 (-3.5A)
STU  A 100 ( 4.6A)
STU  A 100 (-4.5A)
 0.60A 1xbbA-1u59A:
40.0		 1xbbA-1u59A:
60.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		5 VAL A  42
ALA A  55
MET A 105
GLY A 110
LEU A 158
 None
 0.53A 1xbbA-1u5qA:
27.6		 1xbbA-1u5qA:
23.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU X  17
VAL X  25
ALA X  37
GLY X  88
LEU X 137
 STU  X 902 (-3.8A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.5A)
STU  X 902 (-4.4A)
 0.54A 1xbbA-2dq7X:
35.2		 1xbbA-2dq7X:
37.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		5 VAL A  42
ALA A  55
MET A 105
GLY A 110
LEU A 158
 STU  A 400 ( 4.8A)
STU  A 400 (-3.2A)
STU  A 400 ( 3.7A)
STU  A 400 (-3.4A)
STU  A 400 ( 4.6A)
 0.44A 1xbbA-2gcdA:
28.4		 1xbbA-2gcdA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LEU A 273
VAL A 281
ALA A 293
GLY A 344
LEU A 393
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
 0.36A 1xbbA-2h8hA:
30.6		 1xbbA-2h8hA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LEU A 273
VAL A 281
ALA A 293
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.56A 1xbbA-2hckA:
30.2		 1xbbA-2hckA:
25.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 251
VAL A 259
ALA A 271
GLY A 322
LEU A 371
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
 0.39A 1xbbA-2hk5A:
35.0		 1xbbA-2hk5A:
36.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hw6 MAP
KINASE-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  55
VAL A  63
ALA A  76
GLY A 130
LEU A 177
 None
 0.54A 1xbbA-2hw6A:
22.0		 1xbbA-2hw6A:
23.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 248
VAL A 256
ALA A 269
GLY A 321
LEU A 370
 GIN  A 600 ( 4.6A)
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
None
GIN  A 600 (-4.7A)
 0.50A 1xbbA-2hz0A:
32.7		 1xbbA-2hz0A:
39.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		5 VAL A 436
ALA A 452
MET A 499
GLY A 505
LEU A 553
 BII  A1687 ( 4.7A)
BII  A1687 (-3.5A)
BII  A1687 (-4.1A)
BII  A1687 (-3.6A)
BII  A1687 (-4.2A)
 0.52A 1xbbA-2jkmA:
34.3		 1xbbA-2jkmA:
39.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ozo TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		7 LEU A 344
ALA A 367
MET A 414
MET A 416
ALA A 417
GLY A 419
LEU A 468
 ANP  A 615 (-4.4A)
ANP  A 615 (-3.3A)
ANP  A 615 ( 3.9A)
ANP  A 615 ( 3.7A)
ANP  A 615 (-3.9A)
None
ANP  A 615 (-4.7A)
 0.90A 1xbbA-2ozoA:
32.2		 1xbbA-2ozoA:
30.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ozo TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		6 LEU A 344
VAL A 352
ALA A 367
MET A 414
GLY A 418
LEU A 468
 ANP  A 615 (-4.4A)
ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 ( 3.9A)
ANP  A 615 ( 4.0A)
ANP  A 615 (-4.7A)
 1.19A 1xbbA-2ozoA:
32.2		 1xbbA-2ozoA:
30.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ozo TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		8 LEU A 344
VAL A 352
ALA A 367
MET A 414
MET A 416
ALA A 417
GLY A 420
LEU A 468
 ANP  A 615 (-4.4A)
ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 ( 3.9A)
ANP  A 615 ( 3.7A)
ANP  A 615 (-3.9A)
ANP  A 615 ( 3.9A)
ANP  A 615 (-4.7A)
 0.71A 1xbbA-2ozoA:
32.2		 1xbbA-2ozoA:
30.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ozo TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		8 LEU A 344
VAL A 352
MET A 414
MET A 416
ALA A 417
GLY A 420
PRO A 421
LEU A 468
 ANP  A 615 (-4.4A)
ANP  A 615 (-4.5A)
ANP  A 615 ( 3.9A)
ANP  A 615 ( 3.7A)
ANP  A 615 (-3.9A)
ANP  A 615 ( 3.9A)
ANP  A 615 (-3.7A)
ANP  A 615 (-4.7A)
 0.79A 1xbbA-2ozoA:
32.2		 1xbbA-2ozoA:
30.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		5 LEU A  25
VAL A  33
ALA A  46
GLY A 109
LEU A 156
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
ATP  A 381 ( 4.8A)
 0.45A 1xbbA-2phkA:
25.7		 1xbbA-2phkA:
24.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 487
VAL A 495
ALA A 515
ALA A 567
GLY A 570
LEU A 633
 None
 0.54A 1xbbA-2psqA:
34.7		 1xbbA-2psqA:
33.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 724
VAL A 732
ALA A 749
GLY A 802
LEU A 850
 GW7  A   1 ( 4.2A)
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
 0.51A 1xbbA-2r4bA:
30.4		 1xbbA-2r4bA:
39.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A1002
VAL A1010
ALA A1028
MET A1076
GLY A1082
 S91  A   1 ( 4.1A)
S91  A   1 ( 4.9A)
S91  A   1 (-3.2A)
S91  A   1 ( 4.9A)
S91  A   1 (-3.3A)
 0.37A 1xbbA-2z8cA:
31.9		 1xbbA-2z8cA:
32.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 LEU A 253
VAL A 261
ALA A 273
GLY A 325
LEU A 374
 None
 0.44A 1xbbA-2zv7A:
34.0		 1xbbA-2zv7A:
36.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 487
VAL A 495
ALA A 515
ALA A 567
GLY A 570
LEU A 633
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 (-3.8A)
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
 0.51A 1xbbA-3b2tA:
34.8		 1xbbA-3b2tA:
37.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 484
VAL A 492
ALA A 512
ALA A 564
GLY A 567
LEU A 630
 C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
C4F  A   1 (-3.5A)
None
C4F  A   1 (-4.6A)
 0.78A 1xbbA-3c4fA:
30.3		 1xbbA-3c4fA:
37.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 158
ALA A 169
MET A 220
ALA A 223
GLY A 226
PRO A 227
LEU A 275
 VIN  A6331 (-4.7A)
VIN  A6331 (-3.4A)
VIN  A6331 (-3.7A)
VIN  A6331 (-3.8A)
VIN  A6331 (-3.4A)
None
VIN  A6331 (-4.5A)
 0.42A 1xbbA-3dtcA:
26.9		 1xbbA-3dtcA:
33.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		6 LEU A  29
VAL A  37
ALA A  50
MET A 100
GLY A 106
LEU A 153
 None
 0.90A 1xbbA-3dxnA:
22.9		 1xbbA-3dxnA:
30.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fzp PROTEIN TYROSINE
KINASE 2 BETA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 431
VAL A 439
ALA A 455
MET A 502
GLY A 508
LEU A 556
 AGS  A 999 ( 4.4A)
AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
None
None
AGS  A 999 (-4.5A)
 0.80A 1xbbA-3fzpA:
33.4		 1xbbA-3fzpA:
38.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A 217
ALA A 228
MET A 279
GLY A 285
LEU A 340
 ADP  A 900 (-4.3A)
ADP  A 900 (-3.4A)
ADP  A 900 (-3.6A)
ADP  A 900 ( 4.2A)
ADP  A 900 (-4.6A)
 0.55A 1xbbA-3g2fA:
27.7		 1xbbA-3g2fA:
28.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  39
VAL A  47
ALA A  60
ALA A 113
GLY A 116
LEU A 165
 QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-3.9A)
None
None
 0.73A 1xbbA-3lm5A:
26.9		 1xbbA-3lm5A:
24.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A1005
VAL A1013
ALA A1031
MET A1079
GLY A1085
 None
None
None
CCX  A   1 ( 3.9A)
None
 0.41A 1xbbA-3lw0A:
29.3		 1xbbA-3lw0A:
33.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  49
VAL A  57
ALA A  70
MET A 120
GLY A 126
LEU A 173
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
XFE  A 351 ( 4.0A)
None
XFE  A 351 (-4.6A)
 0.82A 1xbbA-3mvjA:
23.7		 1xbbA-3mvjA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  88
VAL A  96
ALA A 109
ALA A 162
GLY A 165
LEU A 212
 JOZ  A 361 (-4.1A)
JOZ  A 361 ( 4.7A)
JOZ  A 361 (-3.4A)
JOZ  A 361 (-3.8A)
None
None
 0.71A 1xbbA-3nuuA:
25.4		 1xbbA-3nuuA:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		5 LEU A 192
VAL A 200
ALA A 213
GLY A 269
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
None
AMP  A 577 (-4.8A)
 0.46A 1xbbA-3nyoA:
25.1		 1xbbA-3nyoA:
19.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 726
VAL A 734
ALA A 751
GLY A 804
LEU A 852
 03Q  A   1 (-3.8A)
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
 0.52A 1xbbA-3pp0A:
33.9		 1xbbA-3pp0A:
36.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 423
VAL A 431
ALA A 443
GLY A 495
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.38A 1xbbA-3sxsA:
33.2		 1xbbA-3sxsA:
37.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 484
VAL A 492
ALA A 512
ALA A 564
GLY A 567
LEU A 630
 07J  A   1 ( 4.3A)
07J  A   1 (-4.0A)
07J  A   1 (-3.5A)
07J  A   1 (-3.8A)
07J  A   1 (-3.7A)
07J  A   1 ( 4.4A)
 0.74A 1xbbA-3tt0A:
30.4		 1xbbA-3tt0A:
32.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 361
VAL A 369
ALA A 382
MET A 433
GLY A 439
LEU A 486
 07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 ( 4.3A)
None
07U  A   1 (-4.3A)
 0.74A 1xbbA-3txoA:
11.5		 1xbbA-3txoA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		5 LEU A 295
VAL A 303
ALA A 315
GLY A 369
LEU A 423
 None
 0.48A 1xbbA-3ulzA:
26.5		 1xbbA-3ulzA:
26.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 544
VAL A 552
ALA A 570
GLY A 623
LEU A 686
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-3.2A)
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
 0.39A 1xbbA-3v5qA:
30.8		 1xbbA-3v5qA:
33.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w18 AURORA KINASE A

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A 139
VAL A 147
ALA A 160
ALA A 213
GLY A 216
LEU A 263
 N13  A 501 (-3.7A)
N13  A 501 ( 4.7A)
N13  A 501 ( 4.1A)
N13  A 501 (-3.7A)
N13  A 501 (-3.5A)
N13  A 501 (-4.5A)
 0.69A 1xbbA-3w18A:
21.7		 1xbbA-3w18A:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  75
VAL A  83
ALA A  96
MET A 144
GLY A 150
LEU A 198
 ANP  A 401 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
CHU  A 403 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
 0.51A 1xbbA-3wigA:
23.2		 1xbbA-3wigA:
25.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 840
VAL A 848
ALA A 866
GLY A 922
LEU A1035
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
 0.41A 1xbbA-3wzdA:
31.1		 1xbbA-3wzdA:
35.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A1951
VAL A1959
ALA A1978
GLY A2032
LEU A2086
 VGH  A3000 ( 4.4A)
None
VGH  A3000 (-3.4A)
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
 0.31A 1xbbA-3zbfA:
28.9		 1xbbA-3zbfA:
33.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af3 AURORA KINASE B

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  83
VAL A  91
ALA A 104
ALA A 157
GLY A 160
LEU A 207
 VX6  A 500 (-3.8A)
VX6  A 500 ( 4.8A)
VX6  A 500 (-3.4A)
VX6  A 500 (-3.7A)
VX6  A 500 (-3.3A)
VX6  A 500 (-4.6A)
 0.48A 1xbbA-4af3A:
19.5		 1xbbA-4af3A:
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 840
VAL A 848
ALA A 866
GLY A 922
LEU A1035
 B49  A2000 (-3.7A)
None
B49  A2000 (-3.5A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
 0.47A 1xbbA-4agdA:
31.0		 1xbbA-4agdA:
32.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 560
VAL A 568
ALA A 586
GLY A 639
LEU A 699
 LTI  A1839 ( 4.2A)
None
LTI  A1839 (-3.3A)
LTI  A1839 (-3.4A)
LTI  A1839 (-4.2A)
 0.49A 1xbbA-4at3A:
30.3		 1xbbA-4at3A:
34.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  42
VAL A  50
ALA A  63
GLY A 116
LEU A 164
 XZN  A1317 (-3.6A)
XZN  A1317 ( 4.7A)
XZN  A1317 (-3.5A)
XZN  A1317 ( 3.7A)
XZN  A1317 (-4.7A)
 0.48A 1xbbA-4bc6A:
23.0		 1xbbA-4bc6A:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		6 LEU A 246
VAL A 254
ALA A 267
ALA A 321
GLY A 324
LEU A 371
 None
 0.74A 1xbbA-4c0tA:
23.8		 1xbbA-4c0tA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		6 LEU A  22
VAL A  30
ALA A  43
MET A  93
GLY A  99
LEU A 146
 STU  A1550 (-4.3A)
None
STU  A1550 (-3.1A)
STU  A1550 (-3.7A)
STU  A1550 (-3.4A)
STU  A1550 (-4.3A)
 0.86A 1xbbA-4cfhA:
25.7		 1xbbA-4cfhA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 LEU A 663
VAL A 671
ALA A 684
MET A 737
ALA A 740
GLY A 743
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-4.2A)
AGS  A1985 (-3.9A)
None
AGS  A1985 (-4.8A)
 0.57A 1xbbA-4crsA:
23.6		 1xbbA-4crsA:
21.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 515
VAL A 523
ALA A 541
GLY A 594
LEU A 656
 None
 0.32A 1xbbA-4f0iA:
30.5		 1xbbA-4f0iA:
32.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 377
VAL A 385
ALA A 400
MET A 448
MET A 450
ALA A 451
GLY A 454
PRO A 455
LEU A 501
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 (-3.6A)
0SB  A 701 (-3.5A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.5A)
0SB  A 701 (-4.3A)
0SB  A 701 (-4.4A)
 0.32A 1xbbA-4f4pA:
42.4		 1xbbA-4f4pA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fl3 TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		9 LEU A 377
VAL A 385
ALA A 400
MET A 448
MET A 450
ALA A 451
GLY A 454
PRO A 455
LEU A 501
 ANP  A 701 ( 4.6A)
ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 ( 3.7A)
ANP  A 701 (-3.5A)
ANP  A 701 (-4.1A)
ANP  A 701 ( 4.2A)
ANP  A 701 (-4.0A)
ANP  A 701 (-4.5A)
 0.49A 1xbbA-4fl3A:
35.3		 1xbbA-4fl3A:
44.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A1122
VAL A1130
ALA A1148
GLY A1202
LEU A1256
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
 0.30A 1xbbA-4fodA:
31.3		 1xbbA-4fodA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 LEU A 855
VAL A 863
ALA A 880
MET A 929
GLY A 935
LEU A 983
 IZA  A2001 (-3.7A)
None
IZA  A2001 (-3.4A)
IZA  A2001 (-4.4A)
IZA  A2001 (-3.3A)
IZA  A2001 ( 4.7A)
 0.55A 1xbbA-4gl9A:
32.6		 1xbbA-4gl9A:
34.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gv1 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 156
VAL A 164
ALA A 177
MET A 227
ALA A 230
GLY A 233
 0XZ  A 501 ( 4.1A)
0XZ  A 501 (-4.5A)
0XZ  A 501 (-3.3A)
0XZ  A 501 (-3.8A)
0XZ  A 501 (-3.7A)
None
 0.68A 1xbbA-4gv1A:
23.5		 1xbbA-4gv1A:
24.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 828
VAL A 836
ALA A 853
MET A 902
GLY A 908
LEU A 956
 19S  A1201 (-3.9A)
19S  A1201 (-4.4A)
19S  A1201 (-3.3A)
19S  A1201 (-3.6A)
19S  A1201 ( 3.8A)
19S  A1201 (-4.5A)
 0.55A 1xbbA-4hviA:
34.4		 1xbbA-4hviA:
35.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		6 LEU A 132
VAL A 140
ALA A 156
ALA A 208
GLY A 211
LEU A 259
 None
 0.35A 1xbbA-4hzsA:
29.7		 1xbbA-4hzsA:
32.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 132
VAL A 140
ALA A 156
ALA A 208
GLY A 211
LEU A 259
 1G0  A 401 ( 4.5A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.8A)
1G0  A 401 ( 4.5A)
1G0  A 401 (-4.6A)
 0.46A 1xbbA-4id7A:
35.5		 1xbbA-4id7A:
38.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrn RHOPTRY KINASE
FAMILY PROTEIN

(Toxoplasma
gondii) 		PF14531
(Kinase-like) 		6 LEU A 258
VAL A 266
ALA A 279
MET A 356
ALA A 359
LEU A 416
 ANP  A 601 ( 4.6A)
ANP  A 601 (-4.1A)
ANP  A 601 ( 3.9A)
ANP  A 601 (-3.3A)
ANP  A 601 (-3.5A)
ANP  A 601 ( 4.9A)
 0.89A 1xbbA-4jrnA:
21.8		 1xbbA-4jrnA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  18
VAL A  26
ALA A  39
MET A  91
GLY A  95
LEU A 143
 631  A 301 (-3.4A)
631  A 301 (-4.6A)
631  A 301 (-3.3A)
631  A 301 (-3.7A)
631  A 301 ( 3.7A)
631  A 301 (-4.0A)
 0.56A 1xbbA-4jxfA:
18.2		 1xbbA-4jxfA:
27.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LEU A 273
VAL A 281
ALA A 293
GLY A 344
LEU A 393
 0J9  A 601 (-4.0A)
0J9  A 601 (-4.4A)
0J9  A 601 (-3.3A)
0J9  A 601 ( 4.1A)
0J9  A 601 (-4.5A)
 0.49A 1xbbA-4k11A:
30.2		 1xbbA-4k11A:
25.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 478
VAL A 486
ALA A 506
ALA A 558
GLY A 561
LEU A 624
 ACP  A 801 (-3.8A)
ACP  A 801 (-4.2A)
ACP  A 801 (-3.3A)
ACP  A 801 (-3.7A)
ACP  A 801 ( 4.6A)
ACP  A 801 (-4.4A)
 0.66A 1xbbA-4k33A:
35.9		 1xbbA-4k33A:
36.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A 421
ALA A 434
MET A 481
GLY A 487
LEU A 533
 None
B49  A 701 (-3.2A)
B49  A 701 (-3.4A)
B49  A 701 ( 3.7A)
B49  A 701 (-4.5A)
 0.43A 1xbbA-4ks8A:
26.1		 1xbbA-4ks8A:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A  50
ALA A  61
MET A 104
ALA A 107
GLY A 110
LEU A 163
 1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
1UL  A 501 (-3.6A)
1UL  A 501 (-3.6A)
1UL  A 501 ( 3.7A)
1UL  A 501 (-4.3A)
 0.64A 1xbbA-4l52A:
27.1		 1xbbA-4l52A:
28.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  33
VAL A  41
ALA A  54
MET A  99
GLY A 105
LEU A 153
 GOL  A 404 ( 3.6A)
GOL  A 404 (-4.5A)
GOL  A 404 ( 3.1A)
GOL  A 403 (-2.7A)
GOL  A 404 (-3.6A)
GOL  A 403 ( 4.4A)
 0.58A 1xbbA-4lg4A:
25.5		 1xbbA-4lg4A:
26.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		5 LEU A 273
VAL A 281
ALA A 293
GLY A 344
LEU A 393
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
 0.39A 1xbbA-4lggA:
30.2		 1xbbA-4lggA:
37.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  46
VAL A  54
ALA A  67
GLY A 128
LEU A 180
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.46A 1xbbA-4o38A:
22.0		 1xbbA-4o38A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 595
VAL A 603
GLY A 693
PRO A 694
LEU A 741
 2TT  A1201 (-4.1A)
2TT  A1201 (-4.2A)
2TT  A1201 (-3.5A)
2TT  A1201 ( 4.4A)
2TT  A1201 (-4.1A)
 0.54A 1xbbA-4oliA:
28.9		 1xbbA-4oliA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otd SERINE/THREONINE-PRO
TEIN KINASE N1

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 LEU A 627
VAL A 635
ALA A 648
GLY A 707
LEU A 753
 None
 0.51A 1xbbA-4otdA:
24.4		 1xbbA-4otdA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 616
VAL A 624
ALA A 642
GLY A 697
LEU A 818
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
 0.42A 1xbbA-4rt7A:
31.5		 1xbbA-4rt7A:
28.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		5 LEU A  14
VAL A  22
ALA A  35
GLY A  87
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.35A 1xbbA-4ueuA:
34.3		 1xbbA-4ueuA:
42.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  40
VAL A  48
ALA A  61
GLY A 114
LEU A 162
 6UI  A 700 ( 4.9A)
None
6UI  A 700 (-3.3A)
6UI  A 700 ( 4.2A)
6UI  A 700 (-4.2A)
 0.41A 1xbbA-4usfA:
23.6		 1xbbA-4usfA:
24.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uy9 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 169
ALA A 223
GLY A 226
PRO A 227
LEU A 275
 None
 0.57A 1xbbA-4uy9A:
20.7		 1xbbA-4uy9A:
31.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase)
PF00226
(DnaJ) 		6 LEU A 104
VAL A 112
ALA A 125
MET A 175
GLY A 181
LEU A 228
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-3.6A)
None
ATP  A 501 (-4.5A)
 0.75A 1xbbA-4wb7A:
23.5		 1xbbA-4wb7A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		6 LEU A 193
VAL A 201
ALA A 214
MET A 264
GLY A 270
LEU A 321
 ANW  A 601 ( 4.0A)
None
ANW  A 601 (-3.4A)
ANW  A 601 (-3.2A)
ANW  A 601 ( 4.5A)
ANW  A 601 (-4.9A)
 0.56A 1xbbA-4wboA:
26.3		 1xbbA-4wboA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wov NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 595
VAL A 603
GLY A 693
PRO A 694
LEU A 741
 3SM  A 901 (-3.9A)
3SM  A 901 ( 4.4A)
3SM  A 901 (-3.0A)
3SM  A 901 (-4.3A)
3SM  A 901 (-4.1A)
 0.44A 1xbbA-4wovA:
28.1		 1xbbA-4wovA:
26.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  52
VAL A  60
ALA A  72
MET A 126
GLY A 132
LEU A 183
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
KSA  A 405 ( 3.7A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
 0.52A 1xbbA-4wsqA:
25.4		 1xbbA-4wsqA:
22.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 473
VAL A 481
ALA A 501
ALA A 553
GLY A 556
LEU A 619
 40M  A1002 ( 4.6A)
40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 ( 3.7A)
40M  A1002 (-4.5A)
 0.74A 1xbbA-4xcuA:
31.1		 1xbbA-4xcuA:
37.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 5 LEU B 267
VAL B 275
ALA B 288
GLY B 340
LEU B 389
 1N1  B 601 (-3.7A)
1N1  B 601 ( 4.9A)
1N1  B 601 (-3.5A)
1N1  B 601 (-3.5A)
1N1  B 601 (-4.3A)
 0.31A 1xbbA-4xeyB:
29.5		 1xbbA-4xeyB:
33.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 616
VAL A 624
ALA A 642
GLY A 697
LEU A 818
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.40A 1xbbA-4xufA:
30.2		 1xbbA-4xufA:
34.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		5 LEU A 408
VAL A 416
ALA A 428
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.44A 1xbbA-4y93A:
30.8		 1xbbA-4y93A:
25.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 484
VAL A 492
ALA A 512
ALA A 564
GLY A 567
LEU A 630
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 (-3.9A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
 0.58A 1xbbA-5a46A:
25.5		 1xbbA-5a46A:
31.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyk AURORA KINASE B-A

(Xenopus laevis) 		PF00069
(Pkinase) 		6 LEU A  99
VAL A 107
ALA A 120
ALA A 173
GLY A 176
LEU A 223
 5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-3.9A)
5U5  A 401 (-3.4A)
5U5  A 401 (-4.7A)
 0.56A 1xbbA-5eykA:
25.1		 1xbbA-5eykA:
25.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 903
VAL A 911
ALA A 928
GLY A 984
LEU A1030
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
5U3  A1200 (-3.2A)
5U3  A1200 (-4.4A)
 0.52A 1xbbA-5f1zA:
32.4		 1xbbA-5f1zA:
37.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 730
VAL A 738
ALA A 756
ALA A 807
GLY A 810
LEU A 881
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 ( 3.5A)
PTR  A 809 (-2.4A)
PP1  A2012 (-4.6A)
 0.61A 1xbbA-5fm2A:
33.4		 1xbbA-5fm2A:
32.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 599
VAL A 607
ALA A 625
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.58A 1xbbA-5grnA:
31.4		 1xbbA-5grnA:
34.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  57
VAL A  65
ALA A  77
MET A 130
GLY A 136
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 (-3.4A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
 0.57A 1xbbA-5i3oA:
24.7		 1xbbA-5i3oA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		6 LEU A  22
VAL A  30
ALA A  43
MET A  93
GLY A  99
LEU A 146
 STU  A 601 (-4.1A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 ( 3.9A)
STU  A 601 ( 4.0A)
STU  A 601 (-4.5A)
 0.97A 1xbbA-5isoA:
24.8		 1xbbA-5isoA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  30
ALA A  43
MET A  90
GLY A  96
LEU A 143
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 (-3.5A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
 0.42A 1xbbA-5j5tA:
22.9		 1xbbA-5j5tA:
20.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 718
VAL A 726
ALA A 743
MET A 790
GLY A 796
LEU A 844
 6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-3.4A)
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.8A)
 0.75A 1xbbA-5j9zA:
33.4		 1xbbA-5j9zA:
38.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  49
ALA A  60
MET A 110
GLY A 116
LEU A 163
 None
STU  A 901 (-3.3A)
STU  A 901 (-3.7A)
STU  A 901 (-3.5A)
STU  A 901 (-4.5A)
 0.49A 1xbbA-5lohA:
21.1		 1xbbA-5lohA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5

(Homo sapiens) 		no annotation 6 LEU A 686
VAL A 694
ALA A 707
MET A 754
GLY A 760
LEU A 810
 9E1  A1001 (-3.7A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
9E1  A1001 (-2.8A)
9E1  A1001 (-3.4A)
9E1  A1001 (-4.5A)
 0.83A 1xbbA-5vilA:
27.7		 1xbbA-5vilA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wnm RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 4

(Mus musculus) 		no annotation 5 VAL A  36
ALA A  49
MET A  96
GLY A 102
LEU A 150
 VX6  A 402 (-4.6A)
VX6  A 402 (-3.2A)
VX6  A 402 (-3.7A)
VX6  A 402 (-3.5A)
VX6  A 402 (-4.4A)
 0.35A 1xbbA-5wnmA:
29.4		 1xbbA-5wnmA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 5 LEU A 891
VAL A 899
ALA A 917
GLY A 969
LEU A1017
 ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
 0.48A 1xbbA-5wnoA:
29.2		 1xbbA-5wnoA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 5 LEU A  33
VAL A  41
ALA A  54
GLY A 105
LEU A 153
 ANP  A 501 ( 3.8A)
ANP  A 501 (-4.4A)
ANP  A 501 ( 3.7A)
ANP  A 501 ( 4.0A)
ANP  A 501 (-4.6A)
 0.40A 1xbbA-6ao5A:
23.0		 1xbbA-6ao5A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bql CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 5 VAL A 179
ALA A 192
GLY A 273
PRO A 274
LEU A 319
 BI9  A 501 ( 4.8A)
BI9  A 501 (-3.3A)
BI9  A 501 (-3.3A)
None
BI9  A 501 (-4.7A)
 0.36A 1xbbA-6bqlA:
25.7		 1xbbA-6bqlA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 6 LEU A 881
VAL A 889
ALA A 906
MET A 956
GLY A 962
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-4.2A)
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
 0.64A 1xbbA-6c7yA:
32.8		 1xbbA-6c7yA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccf CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 1

(Homo sapiens) 		no annotation 5 VAL A 142
ALA A 155
GLY A 236
PRO A 237
LEU A 282
 H1N  A 501 (-4.4A)
H1N  A 501 (-3.4A)
H1N  A 501 (-3.6A)
H1N  A 501 ( 4.5A)
H1N  A 501 (-4.8A)
 0.39A 1xbbA-6ccfA:
19.6		 1xbbA-6ccfA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmj CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 5 VAL A 179
ALA A 192
GLY A 273
PRO A 274
LEU A 319
 F6J  A 501 (-4.6A)
F6J  A 501 (-3.4A)
F6J  A 501 ( 3.7A)
F6J  A 501 (-4.6A)
F6J  A 501 (-4.5A)
 0.47A 1xbbA-6cmjA:
25.1		 1xbbA-6cmjA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		no annotation 6 LEU A 730
VAL A 738
ALA A 756
ALA A 807
GLY A 810
LEU A 881
 ADN  A1104 ( 4.0A)
ADN  A1104 (-4.4A)
ADN  A1104 (-3.4A)
ADN  A1104 (-3.6A)
ADN  A1104 ( 3.8A)
ADN  A1104 (-4.3A)
 0.53A 1xbbA-6fekA:
33.8		 1xbbA-6fekA:
16.44