SIMILAR PATTERNS OF AMINO ACIDS FOR 1X8V_A_ESLA472_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b48 PROTEIN (GLUTATHIONE
S-TRANSFERASE)

(Mus musculus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 MET A  64
VAL A  58
LEU A  57
MET A  44
 None
 1.18A 1x8vA-1b48A:
0.0		 1x8vA-1b48A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1be4 NUCLEOSIDE
DIPHOSPHATE
TRANSFERASE

(Bos taurus) 		PF00334
(NDK) 		4 MET A  68
VAL A  65
LEU A  64
PHE A  60
 None
None
PCG  A 160 ( 4.6A)
PCG  A 160 (-3.4A)
 1.01A 1x8vA-1be4A:
undetectable		 1x8vA-1be4A:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dju AROMATIC
AMINOTRANSFERASE

(Pyrococcus
horikoshii) 		PF00155
(Aminotran_1_2) 		4 MET A  91
VAL A  92
LEU A  93
MET A 102
 None
 1.19A 1x8vA-1djuA:
0.0		 1x8vA-1djuA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		4 MET A  38
MET A  58
VAL A  61
LEU A  62
 None
 0.91A 1x8vA-1fd9A:
0.0		 1x8vA-1fd9A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iiu PLASMA
RETINOL-BINDING
PROTEIN

(Gallus gallus) 		PF00061
(Lipocalin) 		4 MET A  73
VAL A  93
LEU A  97
PHE A  96
 RTL  A 176 ( 4.0A)
None
RTL  A 176 (-4.0A)
None
 1.15A 1x8vA-1iiuA:
0.0		 1x8vA-1iiuA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iiw SLR1257 PROTEIN

(Synechocystis
sp. PCC 6803) 		PF00497
(SBP_bac_3) 		4 MET A 160
VAL A 159
LEU A  98
PHE A 108
 None
 1.16A 1x8vA-1iiwA:
0.0		 1x8vA-1iiwA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jcm INDOLE-3-GLYCEROL-PH
OSPHATE SYNTHASE

(Escherichia
coli) 		PF00218
(IGPS) 		4 VAL P   4
LEU P   5
PHE P 116
MET P 137
 None
 1.21A 1x8vA-1jcmP:
0.0		 1x8vA-1jcmP:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lba T7 LYSOZYME

(Escherichia
virus T7) 		PF01510
(Amidase_2) 		4 VAL A 145
LEU A 144
PHE A  95
MET A 100
 None
 1.18A 1x8vA-1lbaA:
undetectable		 1x8vA-1lbaA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ndl NUCLEOSIDE
DIPHOSPHATE KINASE

(Drosophila
melanogaster) 		PF00334
(NDK) 		4 MET A  69
VAL A  66
LEU A  65
PHE A  61
 None
 1.06A 1x8vA-1ndlA:
0.0		 1x8vA-1ndlA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nld FAB1583

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL H  37
LEU H  48
PHE H  63
MET H  82
 None
 1.15A 1x8vA-1nldH:
undetectable		 1x8vA-1nldH:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r0u PROTEIN YWIB

(Bacillus
subtilis) 		PF09148
(DUF1934) 		4 MET A  89
VAL A 122
LEU A  96
MET A  73
 None
 1.11A 1x8vA-1r0uA:
undetectable		 1x8vA-1r0uA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t2q FAB NNA7 LIGHT CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL H  38
LEU H  49
PHE H  64
MET H  83
 None
 1.12A 1x8vA-1t2qH:
undetectable		 1x8vA-1t2qH:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zs6 NUCLEOSIDE
DIPHOSPHATE KINASE 3

(Homo sapiens) 		PF00334
(NDK) 		4 MET A  85
VAL A  82
LEU A  81
PHE A  77
 None
None
ADP  A 201 (-4.1A)
ADP  A 201 (-3.5A)
 1.00A 1x8vA-1zs6A:
undetectable		 1x8vA-1zs6A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2abq FRUCTOSE 1-PHOSPHATE
KINASE

(Bacillus
halodurans) 		PF00294
(PfkB) 		4 VAL A   5
LEU A   7
PHE A  58
MET A 139
 None
 1.06A 1x8vA-2abqA:
undetectable		 1x8vA-2abqA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g64 PUTATIVE 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE

(Caenorhabditis
elegans) 		PF01242
(PTPS) 		4 MET A  75
VAL A  78
LEU A  79
PHE A  15
 None
 0.97A 1x8vA-2g64A:
undetectable		 1x8vA-2g64A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hur NUCLEOSIDE
DIPHOSPHATE KINASE

(Escherichia
coli) 		PF00334
(NDK) 		4 MET A  67
VAL A  64
LEU A  63
PHE A  59
 None
 0.96A 1x8vA-2hurA:
undetectable		 1x8vA-2hurA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jeo URIDINE-CYTIDINE
KINASE 1

(Homo sapiens) 		PF00485
(PRK) 		4 MET A  97
VAL A 135
LEU A  25
PHE A 152
 None
 0.98A 1x8vA-2jeoA:
undetectable		 1x8vA-2jeoA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jig PROLYL-4 HYDROXYLASE

(Chlamydomonas
reinhardtii) 		PF13640
(2OG-FeII_Oxy_3) 		4 VAL A  42
LEU A  54
PHE A  57
MET A 165
 None
 0.89A 1x8vA-2jigA:
undetectable		 1x8vA-2jigA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ktq PROTEIN (LARGE
FRAGMENT OF DNA
POLYMERASE I)

(Thermus
aquaticus) 		PF00476
(DNA_pol_A)
PF09281
(Taq-exonuc) 		4 MET A 761
VAL A 440
LEU A 441
PHE A 564
 None
 1.08A 1x8vA-2ktqA:
undetectable		 1x8vA-2ktqA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nck NUCLEOSIDE
DIPHOSPHATE KINASE

(Myxococcus
xanthus) 		no annotation 4 MET R  67
VAL R  64
LEU R  63
PHE R  59
 None
 0.90A 1x8vA-2nckR:
undetectable		 1x8vA-2nckR:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o90 DIHYDRONEOPTERIN
ALDOLASE

(Escherichia
coli) 		PF02152
(FolB) 		4 VAL A  79
LEU A  83
PHE A  87
MET A  34
 None
 1.20A 1x8vA-2o90A:
undetectable		 1x8vA-2o90A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okj GLUTAMATE
DECARBOXYLASE 1

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		4 VAL A 337
LEU A 282
PHE A 303
MET A 276
 None
 1.12A 1x8vA-2okjA:
undetectable		 1x8vA-2okjA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oor NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA

(Rhodospirillum
rubrum) 		PF02233
(PNTB) 		4 MET C 185
LEU C 161
PHE C 126
MET C  43
 None
 1.19A 1x8vA-2oorC:
undetectable		 1x8vA-2oorC:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2y ALPHA-RIBAZOLE-5'-PH
OSPHATE PHOSPHATASE

(Thermus
thermophilus) 		PF00300
(His_Phos_1) 		4 MET A   1
MET A   5
LEU A 130
PHE A  48
 None
 0.93A 1x8vA-2p2yA:
undetectable		 1x8vA-2p2yA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qpq PROTEIN BUG27

(Bordetella
pertussis) 		PF03401
(TctC) 		4 MET A 121
VAL A 108
LEU A 179
MET A 157
 None
 0.97A 1x8vA-2qpqA:
undetectable		 1x8vA-2qpqA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2sas SARCOPLASMIC
CALCIUM-BINDING
PROTEIN

(Branchiostoma
lanceolatum) 		PF13833
(EF-hand_8) 		4 MET A  54
LEU A  58
PHE A  31
MET A  34
 None
 0.98A 1x8vA-2sasA:
undetectable		 1x8vA-2sasA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v95 CORTICOSTEROID-BINDI
NG GLOBULIN

(Rattus
norvegicus) 		PF00079
(Serpin) 		4 MET A 314
LEU A 109
PHE A 113
MET A 101
 None
 1.17A 1x8vA-2v95A:
undetectable		 1x8vA-2v95A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9k UNCHARACTERIZED
PROTEIN FLJ32312

(Homo sapiens) 		no annotation 4 MET A 250
VAL A 249
LEU A 253
PHE A 261
 None
 1.22A 1x8vA-2v9kA:
undetectable		 1x8vA-2v9kA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wq9 RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		4 MET A  73
VAL A  93
LEU A  97
PHE A  96
 OLA  A1179 ( 4.9A)
None
None
None
 1.20A 1x8vA-2wq9A:
undetectable		 1x8vA-2wq9A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ww2 ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		PF07971
(Glyco_hydro_92) 		4 MET A 207
VAL A 156
LEU A 250
PHE A 242
 None
 1.11A 1x8vA-2ww2A:
undetectable		 1x8vA-2ww2A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhy 6-PHOSPHO-BETA-GLUCO
SIDASE BGLA

(Escherichia
coli) 		PF00232
(Glyco_hydro_1) 		4 MET A 211
VAL A 214
LEU A 215
PHE A 219
 None
 1.11A 1x8vA-2xhyA:
undetectable		 1x8vA-2xhyA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ypq PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE AROG

(Mycobacterium
tuberculosis) 		PF01474
(DAHP_synth_2) 		4 MET A 109
VAL A 112
LEU A 113
PHE A  80
 None
 1.05A 1x8vA-2ypqA:
undetectable		 1x8vA-2ypqA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z02 PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Methanocaldococcus
jannaschii) 		PF01259
(SAICAR_synt) 		4 VAL A 167
LEU A 168
PHE A 172
MET A 205
 None
 1.10A 1x8vA-2z02A:
undetectable		 1x8vA-2z02A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a31 PROBABLE
THREONYL-TRNA
SYNTHETASE 1

(Aeropyrum
pernix) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		4 MET A 185
VAL A 188
LEU A 189
MET A 265
 None
 0.88A 1x8vA-3a31A:
undetectable		 1x8vA-3a31A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e57 UNCHARACTERIZED
PROTEIN TM1382

(Thermotoga
maritima) 		PF00293
(NUDIX) 		4 VAL A 190
LEU A 191
PHE A 195
MET A  64
 None
 0.97A 1x8vA-3e57A:
undetectable		 1x8vA-3e57A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ed4 ARYLSULFATASE

(Escherichia
coli) 		PF00884
(Sulfatase) 		4 VAL A 219
LEU A 223
PHE A 232
MET A 306
 None
 1.15A 1x8vA-3ed4A:
undetectable		 1x8vA-3ed4A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		4 MET A 213
VAL A 216
LEU A 217
PHE A 120
 None
 0.75A 1x8vA-3f3zA:
undetectable		 1x8vA-3f3zA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4z MALTOSE-BINDING
PERIPLASMIC PROTEIN
FUSED WITH ALLERGEN
DERP7

(Dermatophagoides
pteronyssinus;
Escherichia
coli) 		PF13416
(SBP_bac_8)
PF16984
(Grp7_allergen) 		4 MET A1198
VAL A1201
LEU A1202
PHE A1206
 None
 1.05A 1x8vA-3h4zA:
undetectable		 1x8vA-3h4zA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn8 SYNAPTOTAGMIN-3

(Rattus
norvegicus) 		PF00168
(C2) 		4 MET A 551
VAL A 559
LEU A 437
PHE A 435
 None
 1.18A 1x8vA-3hn8A:
undetectable		 1x8vA-3hn8A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica) 		PF03063
(Prismane) 		4 MET A 127
VAL A 125
LEU A 124
PHE A 251
 None
 1.18A 1x8vA-3i04A:
undetectable		 1x8vA-3i04A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I)
PF01590
(GAF)
PF13185
(GAF_2) 		4 MET A 694
LEU A 738
PHE A 746
MET A 761
 None
 1.08A 1x8vA-3ibjA:
undetectable		 1x8vA-3ibjA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kg5 B-CELL ANTIGEN
RECEPTOR
COMPLEX-ASSOCIATED
PROTEIN BETA CHAIN

(Homo sapiens) 		PF07686
(V-set) 		4 MET A  96
VAL A 142
LEU A 140
MET A  63
 None
 1.08A 1x8vA-3kg5A:
undetectable		 1x8vA-3kg5A:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mop INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE-LIKE 2

(Homo sapiens) 		PF00531
(Death) 		4 VAL K  75
LEU K  78
PHE K  31
MET K  20
 None
 1.08A 1x8vA-3mopK:
undetectable		 1x8vA-3mopK:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0l SERINE
HYDROXYMETHYLTRANSFE
RASE

(Campylobacter
jejuni) 		PF00464
(SHMT) 		4 VAL A 294
LEU A 295
PHE A 300
MET A 314
 None
 1.13A 1x8vA-3n0lA:
undetectable		 1x8vA-3n0lA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o80 HEXOKINASE

(Kluyveromyces
lactis) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		4 MET A 313
VAL A 316
LEU A 317
PHE A 327
 None
 1.14A 1x8vA-3o80A:
1.1		 1x8vA-3o80A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odo RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1

(Homo sapiens) 		PF00621
(RhoGEF) 		4 MET A 434
VAL A 437
LEU A 438
PHE A 461
 None
 0.91A 1x8vA-3odoA:
undetectable		 1x8vA-3odoA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pj9 NUCLEOSIDE
DIPHOSPHATE KINASE

(Campylobacter
jejuni) 		PF00334
(NDK) 		4 MET A  65
VAL A  62
LEU A  61
PHE A  57
 None
 1.06A 1x8vA-3pj9A:
undetectable		 1x8vA-3pj9A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r03 NUDIX HYDROLASE

(Rhodospirillum
rubrum) 		PF14815
(NUDIX_4) 		4 VAL A 126
LEU A  39
PHE A  54
MET A 136
 None
 1.10A 1x8vA-3r03A:
undetectable		 1x8vA-3r03A:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r2e DIHYDRONEOPTERIN
ALDOLASE

(Yersinia pestis) 		PF02152
(FolB) 		4 VAL A  79
LEU A  83
PHE A  87
MET A  34
 None
 1.16A 1x8vA-3r2eA:
undetectable		 1x8vA-3r2eA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N

(Escherichia
coli) 		no annotation 4 MET N 174
VAL N 254
LEU N 257
PHE N 186
 None
 1.14A 1x8vA-3rkoN:
undetectable		 1x8vA-3rkoN:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uv1 DER F 7 ALLERGEN

(Dermatophagoides
farinae) 		PF16984
(Grp7_allergen) 		4 MET A 181
VAL A 184
LEU A 185
PHE A 189
 None
 0.93A 1x8vA-3uv1A:
undetectable		 1x8vA-3uv1A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vfg 3F8 HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL H  37
LEU H  48
PHE H  63
MET H  82
 None
 1.07A 1x8vA-3vfgH:
undetectable		 1x8vA-3vfgH:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vk5 MOEO5

(Streptomyces
viridosporus) 		PF01884
(PcrB) 		4 VAL A  95
LEU A  96
PHE A  98
MET A  79
 None
 1.10A 1x8vA-3vk5A:
undetectable		 1x8vA-3vk5A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vte TETRAHYDROCANNABINOL
IC ACID SYNTHASE

(Cannabis sativa) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 MET A 264
VAL A 398
LEU A 401
PHE A 293
 None
 1.20A 1x8vA-3vteA:
undetectable		 1x8vA-3vteA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zkm FAB HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL C  37
LEU C  48
PHE C  63
MET C  82
 None
None
GOL  C1217 (-4.0A)
None
 1.10A 1x8vA-3zkmC:
undetectable		 1x8vA-3zkmC:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zto NUCLEOSIDE
DIPHOSPHATE KINASE

(Aquifex
aeolicus) 		PF00334
(NDK) 		4 MET A  67
VAL A  64
LEU A  63
PHE A  59
 None
None
SO4  A 200 ( 4.7A)
None
 0.95A 1x8vA-3ztoA:
undetectable		 1x8vA-3ztoA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ajt PROTEIN Z-DEPENDENT
PROTEASE INHIBITOR

(Mus musculus) 		PF00079
(Serpin) 		4 MET A  92
LEU A  88
PHE A  83
MET A 331
 None
 1.03A 1x8vA-4ajtA:
undetectable		 1x8vA-4ajtA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cja BURRH

(Paraburkholderia
rhizoxinica) 		PF03377
(TAL_effector) 		4 VAL A 406
LEU A 407
PHE A 412
MET A 420
 None
 0.73A 1x8vA-4cjaA:
undetectable		 1x8vA-4cjaA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dgf SULFATE TRANSPORTER
SULFATE TRANSPORTER
FAMILY PROTEIN

(Wolinella
succinogenes) 		PF01740
(STAS) 		4 MET A 500
MET A 489
VAL A 522
LEU A 519
 None
 1.16A 1x8vA-4dgfA:
undetectable		 1x8vA-4dgfA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ep6 CYTOCHROME P450-LIKE
PROTEIN XPLA

(Rhodococcus
rhodochrous) 		PF00067
(p450) 		4 VAL A 348
LEU A 344
PHE A 341
MET A 318
 None
 1.11A 1x8vA-4ep6A:
30.1		 1x8vA-4ep6A:
24.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fs7 UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF13306
(LRR_5) 		4 VAL A 268
LEU A 247
PHE A 224
MET A 233
 None
 0.97A 1x8vA-4fs7A:
undetectable		 1x8vA-4fs7A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gkl ALPHA-AMYLASE

(Thermotoga
neapolitana) 		PF00128
(Alpha-amylase) 		4 MET A  99
VAL A 100
LEU A 101
PHE A 139
 None
 1.14A 1x8vA-4gklA:
undetectable		 1x8vA-4gklA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grx AMINOTRANSFERASE

(Paracoccus
denitrificans) 		PF00202
(Aminotran_3) 		4 VAL A 422
LEU A 423
PHE A 356
MET A 437
 None
 1.20A 1x8vA-4grxA:
undetectable		 1x8vA-4grxA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		4 MET A 694
LEU A 738
PHE A 746
MET A 761
 None
 1.13A 1x8vA-4htzA:
undetectable		 1x8vA-4htzA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i70 INOSINE-ADENOSINE-GU
ANOSINE-NUCLEOSIDE
HYDROLASE

(Trypanosoma
brucei) 		PF01156
(IU_nuc_hydro) 		4 MET A 237
VAL A 238
LEU A 234
MET A  57
 None
 1.21A 1x8vA-4i70A:
undetectable		 1x8vA-4i70A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4im7 HYPOTHETICAL
OXIDOREDUCTASE YDFI

(Escherichia
coli) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		4 MET A 404
MET A 379
VAL A 383
LEU A 380
 None
 1.19A 1x8vA-4im7A:
1.6		 1x8vA-4im7A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ivn TRANSCRIPTIONAL
REGULATOR

(Vibrio
vulnificus) 		PF01380
(SIS)
PF01418
(HTH_6) 		4 MET A  15
LEU A   7
PHE A  70
MET A  62
 None
 1.19A 1x8vA-4ivnA:
undetectable		 1x8vA-4ivnA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kro CETUXIMAB HEAVY
CHAIN

(Homo sapiens;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL D  37
LEU D  48
PHE D  63
MET D  82
 None
 1.10A 1x8vA-4kroD:
undetectable		 1x8vA-4kroD:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mdv ANNEXIN

(Schistosoma
mansoni) 		PF00191
(Annexin) 		4 VAL A 130
LEU A 131
PHE A 135
MET A 170
 None
 1.09A 1x8vA-4mdvA:
undetectable		 1x8vA-4mdvA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mjd KETOSTEROID
ISOMERASE FOLD
PROTEIN HMUK_0747

(Halomicrobium
mukohataei) 		PF12680
(SnoaL_2) 		4 MET A  49
VAL A  25
LEU A  26
PHE A  30
 None
 1.13A 1x8vA-4mjdA:
undetectable		 1x8vA-4mjdA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nv1 FORMYLTRANSFERASE

(Francisella
tularensis) 		no annotation 4 VAL C  86
LEU C  82
PHE C  78
MET C  55
 None
 1.11A 1x8vA-4nv1C:
undetectable		 1x8vA-4nv1C:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		4 MET A 418
VAL A 420
LEU A 421
PHE A 424
 None
 1.10A 1x8vA-4o9xA:
undetectable		 1x8vA-4o9xA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pzc 3-HYDROXYACYL-COA
DEHYDROGENASE

(Cupriavidus
necator) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 MET A 244
VAL A 246
LEU A 247
PHE A 251
 None
 1.17A 1x8vA-4pzcA:
undetectable		 1x8vA-4pzcA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uwm 3,6-DIKETOCAMPHANE
1,6 MONOOXYGENASE

(Pseudomonas
putida) 		PF00296
(Bac_luciferase) 		4 MET A 294
VAL A 318
LEU A 314
PHE A 281
 FMN  A 400 (-4.6A)
None
None
PGE  A 404 (-4.5A)
 1.14A 1x8vA-4uwmA:
undetectable		 1x8vA-4uwmA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbf NUCLEOSIDE
DIPHOSPHATE KINASE

(Acinetobacter
baumannii) 		PF00334
(NDK) 		4 MET A  67
VAL A  64
LEU A  63
PHE A  59
 None
 0.87A 1x8vA-4wbfA:
undetectable		 1x8vA-4wbfA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro) 		4 MET A 279
VAL A 206
LEU A 207
MET A 286
 None
 1.11A 1x8vA-4wzbA:
undetectable		 1x8vA-4wzbA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zud CHIMERA PROTEIN OF
SOLUBLE CYTOCHROME
B562 AND TYPE-1
ANGIOTENSIN II
RECEPTOR

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		4 MET A 243
VAL A 246
LEU A 247
PHE A 251
 None
 1.04A 1x8vA-4zudA:
2.0		 1x8vA-4zudA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwi GLYCOSIDE HYDROLASE
FAMILY 79

(Burkholderia
pseudomallei) 		PF12891
(Glyco_hydro_44) 		4 VAL A 292
LEU A 253
PHE A 251
MET A 236
 None
 1.17A 1x8vA-5bwiA:
undetectable		 1x8vA-5bwiA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by6 THYMIDYLATE SYNTHASE

(Trichinella
spiralis) 		PF00303
(Thymidylat_synt) 		4 MET A 206
VAL A  78
LEU A  82
PHE A  85
 None
 1.07A 1x8vA-5by6A:
1.1		 1x8vA-5by6A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dxf TREHALOSE-6-PHOSPHAT
E PHOSPHATASE

(Candida
albicans) 		PF00982
(Glyco_transf_20) 		4 VAL A 230
LEU A 228
PHE A 232
MET A 251
 None
 1.11A 1x8vA-5dxfA:
undetectable		 1x8vA-5dxfA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9j MRNA CAP GUANINE-N7
METHYLTRANSFERASE,MR
NA CAP GUANINE-N7
METHYLTRANSFERASE

(Homo sapiens) 		PF03291
(Pox_MCEL) 		4 MET A 179
VAL A 182
LEU A 183
PHE A 187
 None
 0.91A 1x8vA-5e9jA:
undetectable		 1x8vA-5e9jA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eeb ALDEHYDE
DEHYDROGENASE

(Pyrobaculum
ferrireducens) 		PF00171
(Aldedh) 		4 MET A  77
VAL A  80
PHE A  88
MET A 162
 None
 1.15A 1x8vA-5eebA:
undetectable		 1x8vA-5eebA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eor ANTI VACCINIA VIRUS
A27 ANTIBODY 8E3
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL H  38
LEU H  49
PHE H  64
MET H  83
 None
 1.13A 1x8vA-5eorH:
undetectable		 1x8vA-5eorH:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fwj HISTONE DEMETHYLASE
JARID1C

(Homo sapiens) 		PF02373
(JmjC)
PF02375
(JmjN)
PF02928
(zf-C5HC2) 		4 VAL A 486
LEU A 487
PHE A 642
MET A 497
 None
 1.10A 1x8vA-5fwjA:
undetectable		 1x8vA-5fwjA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5huc 3-DEOXY-D-ARABINO-HE
PTULOSONATE
7-PHOSPHATE (DAHP)
SYNTHASE

(Corynebacterium
glutamicum) 		PF01474
(DAHP_synth_2) 		4 MET A 119
VAL A 122
LEU A 123
PHE A  90
 None
 1.15A 1x8vA-5hucA:
undetectable		 1x8vA-5hucA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6o PUTATIVE POLYKETIDE
SYNTHASE

(Brevibacillus
brevis) 		PF14765
(PS-DH) 		4 VAL A2000
LEU A2166
PHE A2216
MET A2213
 None
 1.07A 1x8vA-5j6oA:
undetectable		 1x8vA-5j6oA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kk8 NUCLEOSIDE
DIPHOSPHATE KINASE

(Schistosoma
mansoni) 		PF00334
(NDK) 		4 MET A  65
VAL A  62
LEU A  61
PHE A  57
 None
None
ADP  A 201 (-4.0A)
ADP  A 201 ( 4.0A)
 1.01A 1x8vA-5kk8A:
undetectable		 1x8vA-5kk8A:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kov PL-2 SCFV CHAIN

(Mus musculus) 		PF07686
(V-set) 		4 VAL C  37
LEU C  48
PHE C  63
MET C  82
 None
 1.12A 1x8vA-5kovC:
undetectable		 1x8vA-5kovC:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kyo CYP101J2

(Sphingobium
yanoikuyae) 		PF00067
(p450) 		4 MET A 369
VAL A 372
LEU A 373
PHE A 377
 None
 0.66A 1x8vA-5kyoA:
27.9		 1x8vA-5kyoA:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nmv FAB HEAVY CHAIN

(Mus) 		no annotation 4 VAL H  37
LEU H  48
PHE H  63
MET H  82
 None
 1.07A 1x8vA-5nmvH:
undetectable		 1x8vA-5nmvH:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t0l BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Toxoplasma
gondii) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		4 MET A 507
VAL A 378
LEU A 382
PHE A 385
 None
 1.07A 1x8vA-5t0lA:
undetectable		 1x8vA-5t0lA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tos SERINE/THREONINE-PRO
TEIN KINASE BIK1

(Arabidopsis
thaliana) 		no annotation 4 MET A 324
VAL A 327
LEU A 269
PHE A 265
 None
 1.10A 1x8vA-5tosA:
undetectable		 1x8vA-5tosA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uti QUEUINE
TRNA-RIBOSYLTRANSFER
ASE

(Zymomonas
mobilis) 		no annotation 4 MET A 260
MET A 240
VAL A 243
LEU A 244
 GGB  A 403 (-3.7A)
None
None
None
 0.77A 1x8vA-5utiA:
undetectable		 1x8vA-5utiA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uwy THIOREDOXIN
REDUCTASE

(Streptococcus
pyogenes) 		PF07992
(Pyr_redox_2) 		4 MET A   1
VAL A 296
LEU A 300
PHE A 303
 None
 1.08A 1x8vA-5uwyA:
undetectable		 1x8vA-5uwyA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v6d NUCLEOSIDE
DIPHOSPHATE KINASE

(Neisseria
gonorrhoeae) 		PF00334
(NDK) 		4 MET A  67
VAL A  64
LEU A  63
PHE A  59
 None
None
CIT  A 201 ( 4.7A)
CIT  A 201 (-4.2A)
 0.95A 1x8vA-5v6dA:
undetectable		 1x8vA-5v6dA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vms POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY
KQT MEMBER 1

(Xenopus laevis) 		PF00520
(Ion_trans)
PF03520
(KCNQ_channel) 		4 MET A 149
VAL A 152
LEU A 153
PHE A 157
 None
 1.00A 1x8vA-5vmsA:
2.5		 1x8vA-5vmsA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w6y CHORISMATE MUTASE

(Physcomitrella
patens) 		no annotation 4 MET A 122
VAL A 119
LEU A 118
PHE A 109
 None
 1.03A 1x8vA-5w6yA:
1.0		 1x8vA-5w6yA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wix P-47 PROTEIN

(Clostridium
botulinum) 		no annotation 4 MET A 227
VAL A 332
LEU A 378
PHE A 376
 None
 0.87A 1x8vA-5wixA:
undetectable		 1x8vA-5wixA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b9h PROTEIN HOOK HOMOLOG
3

(Homo sapiens) 		no annotation 4 MET A  41
VAL A  44
LEU A  45
PHE A  53
 None
 1.19A 1x8vA-6b9hA:
undetectable		 1x8vA-6b9hA:
12.81