SIMILAR PATTERNS OF AMINO ACIDS FOR 1X70_A_715A801_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cjb PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)

(Plasmodium
falciparum) 		PF00156
(Pribosyltran) 		3 ARG A  53
SER A  97
TYR A  96
 None
 0.78A 1x70A-1cjbA:
undetectable		 1x70A-1cjbA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1evl THREONYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		3 ARG A 354
SER A 409
TYR A 408
 None
 0.45A 1x70A-1evlA:
0.0		 1x70A-1evlA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f56 PLANTACYANIN

(Spinacia
oleracea) 		PF02298
(Cu_bind_like) 		3 ARG A  54
SER A  46
TYR A  44
 None
 0.59A 1x70A-1f56A:
undetectable		 1x70A-1f56A:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		3 ARG A 430
SER A 381
TYR A 380
 None
 0.51A 1x70A-1k9aA:
2.1		 1x70A-1k9aA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lf9 GLUCOAMYLASE

(Thermoanaerobacterium
thermosaccharolyticum) 		PF00723
(Glyco_hydro_15)
PF09137
(Glucodextran_N) 		3 ARG A 407
SER A 416
TYR A 414
 None
 0.74A 1x70A-1lf9A:
1.4		 1x70A-1lf9A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lgy TRIACYLGLYCEROL
LIPASE

(Rhizopus niveus) 		PF01764
(Lipase_3) 		3 ARG A 198
SER A 115
TYR A 116
 None
 0.66A 1x70A-1lgyA:
5.0		 1x70A-1lgyA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oqc AUGMENTER OF LIVER
REGENERATION

(Rattus
norvegicus) 		PF04777
(Evr1_Alr) 		3 ARG A  99
SER A  57
TYR A  60
 None
None
FAD  A 126 (-4.2A)
 0.77A 1x70A-1oqcA:
undetectable		 1x70A-1oqcA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q33 ADP-RIBOSE
PYROPHOSPHATASE

(Homo sapiens) 		PF00293
(NUDIX) 		3 ARG A 148
SER A  68
TYR A  70
 None
 0.67A 1x70A-1q33A:
0.0		 1x70A-1q33A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		3 ARG A 114
SER A 149
TYR A 148
 None
 0.54A 1x70A-1q5aA:
undetectable		 1x70A-1q5aA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qf6 THREONYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF00587
(tRNA-synt_2b)
PF02824
(TGS)
PF03129
(HGTP_anticodon)
PF07973
(tRNA_SAD) 		3 ARG A 354
SER A 409
TYR A 408
 None
 0.51A 1x70A-1qf6A:
0.1		 1x70A-1qf6A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r5n EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT

(Schizosaccharomyces
pombe) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3) 		3 ARG A 317
SER A 450
TYR A 454
 None
 0.75A 1x70A-1r5nA:
undetectable		 1x70A-1r5nA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rkx CDP-GLUCOSE-4,6-DEHY
DRATASE

(Yersinia
pseudotuberculosis) 		PF16363
(GDP_Man_Dehyd) 		3 ARG A  94
SER A 105
TYR A 104
 None
 0.72A 1x70A-1rkxA:
undetectable		 1x70A-1rkxA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rkx CDP-GLUCOSE-4,6-DEHY
DRATASE

(Yersinia
pseudotuberculosis) 		PF16363
(GDP_Man_Dehyd) 		3 ARG A 224
SER A  98
TYR A  97
 None
 0.75A 1x70A-1rkxA:
undetectable		 1x70A-1rkxA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkm CONSERVED
HYPOTHETICAL PROTEIN
TM1464

(Thermotoga
maritima) 		PF04227
(Indigoidine_A) 		3 ARG A 170
SER A 201
TYR A 199
 None
 0.78A 1x70A-1vkmA:
3.1		 1x70A-1vkmA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x4o SPLICING FACTOR 4

(Mus musculus) 		PF01805
(Surp) 		3 ARG A  26
SER A  57
TYR A  60
 None
 0.61A 1x70A-1x4oA:
undetectable		 1x70A-1x4oA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xc6 BETA-GALACTOSIDASE

(Penicillium sp.) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		3 ARG A 134
SER A 591
TYR A 590
 None
 0.72A 1x70A-1xc6A:
1.4		 1x70A-1xc6A:
20.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2buc DIPEPTIDYL PEPTIDASE
IV

(Sus scrofa) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		3 ARG A 358
SER A 630
TYR A 631
 008  A1767 ( 4.0A)
SO4  A1769 ( 3.0A)
None
 0.68A 1x70A-2bucA:
56.4		 1x70A-2bucA:
88.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c60 HUMAN
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 3
ISOFORM 2

(Homo sapiens) 		PF00564
(PB1) 		3 ARG A  56
SER A  91
TYR A  85
 None
 0.77A 1x70A-2c60A:
undetectable		 1x70A-2c60A:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cq1 PTB-LIKE PROTEIN L

(Homo sapiens) 		no annotation 3 ARG A  59
SER A 115
TYR A 114
 None
 0.60A 1x70A-2cq1A:
undetectable		 1x70A-2cq1A:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e18 NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Pyrococcus
horikoshii) 		PF02540
(NAD_synthase) 		3 ARG A 167
SER A 196
TYR A 197
 None
 0.78A 1x70A-2e18A:
2.4		 1x70A-2e18A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eob 1-PHOSPHATIDYLINOSIT
OL-4,5-BISPHOSPHATE
PHOSPHODIESTERASE
GAMMA 2

(Rattus
norvegicus) 		PF00017
(SH2) 		3 ARG A  47
SER A 119
TYR A 118
 None
 0.75A 1x70A-2eobA:
undetectable		 1x70A-2eobA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f4o PEPTIDE N-GLYCANASE

(Mus musculus) 		PF01841
(Transglut_core) 		3 ARG A 408
SER A 389
TYR A 388
 None
 0.70A 1x70A-2f4oA:
undetectable		 1x70A-2f4oA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fja ADENYLYLSULFATE
REDUCTASE, SUBUNIT A
ADENYLYLSULFATE
REDUCTASE, SUBUNIT B

(Archaeoglobus
fulgidus) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C)
PF12139
(APS-reductase_C)
PF13187
(Fer4_9) 		3 ARG A 265
SER B 752
TYR B 751
 None
SF4  B1100 ( 4.5A)
None
 0.46A 1x70A-2fjaA:
undetectable		 1x70A-2fjaA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuj CONSERVED
HYPOTHETICAL PROTEIN

(Xanthomonas
campestris) 		PF13279
(4HBT_2) 		3 ARG A  17
SER A 106
TYR A 105
 None
 0.78A 1x70A-2fujA:
undetectable		 1x70A-2fujA:
10.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2g5t DIPEPTIDYL PEPTIDASE
4

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		3 ARG A 358
SER A 630
TYR A 631
 None
ACF  A 800 (-1.3A)
None
 0.76A 1x70A-2g5tA:
58.6		 1x70A-2g5tA:
99.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gbx BIPHENYL
2,3-DIOXYGENASE
ALPHA SUBUNIT

(Sphingobium
yanoikuyae) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		3 ARG A 286
SER A 156
TYR A 160
 None
 0.76A 1x70A-2gbxA:
undetectable		 1x70A-2gbxA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n1k FIBRONECTIN

(Homo sapiens) 		PF00041
(fn3) 		3 ARG A  29
SER A  88
TYR A  80
 None
 0.67A 1x70A-2n1kA:
undetectable		 1x70A-2n1kA:
9.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2oae DIPEPTIDYL PEPTIDASE
4

(Rattus
norvegicus) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		3 ARG A 356
SER A 631
TYR A 632
 AIL  A 901 ( 4.7A)
AIL  A 901 ( 2.8A)
None
 0.76A 1x70A-2oaeA:
52.5		 1x70A-2oaeA:
84.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odr PHOSPHOSERYL-TRNA
SYNTHETASE

(Methanococcus
maripaludis) 		PF01409
(tRNA-synt_2d) 		3 ARG B  76
SER B 302
TYR B 273
 None
 0.76A 1x70A-2odrB:
undetectable		 1x70A-2odrB:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okx RHAMNOSIDASE B

(Bacillus sp.
GL1) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		3 ARG A 447
SER A 496
TYR A 497
 GOL  A3035 (-3.0A)
None
GOL  A3002 (-4.7A)
 0.70A 1x70A-2okxA:
undetectable		 1x70A-2okxA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2w CITRATE SYNTHASE

(Thermotoga
maritima) 		PF00285
(Citrate_synt) 		3 ARG A 325
SER A  99
TYR A 196
 FLC  A 401 ( 3.1A)
None
None
 0.67A 1x70A-2p2wA:
undetectable		 1x70A-2p2wA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vt1 SURFACE PRESENTATION
OF ANTIGENS PROTEIN
SPAS

(Shigella
flexneri) 		PF01312
(Bac_export_2) 		3 ARG B 290
SER B 318
TYR B 317
 None
 0.75A 1x70A-2vt1B:
undetectable		 1x70A-2vt1B:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT

(Homo sapiens) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC) 		3 ARG A 256
SER A 373
TYR A 371
 DTP  A1745 (-3.0A)
None
None
 0.58A 1x70A-2wghA:
2.2		 1x70A-2wghA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zk7 GLUCOSE
1-DEHYDROGENASE
RELATED PROTEIN

(Thermoplasma
acidophilum) 		PF13561
(adh_short_C2) 		3 ARG A  26
SER A  73
TYR A  71
 None
 0.58A 1x70A-2zk7A:
4.2		 1x70A-2zk7A:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3anp TRANSCRIPTIONAL
REPRESSOR, TETR
FAMILY

(Thermus
thermophilus) 		no annotation 3 ARG C  13
SER C  62
TYR C  60
 None
 0.78A 1x70A-3anpC:
undetectable		 1x70A-3anpC:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b46 AMINOTRANSFERASE
BNA3

(Saccharomyces
cerevisiae) 		PF00155
(Aminotran_1_2) 		3 ARG A  94
SER A 106
TYR A 105
 None
 0.58A 1x70A-3b46A:
undetectable		 1x70A-3b46A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgh SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12741
(SusD-like) 		3 ARG A 100
SER A 114
TYR A 113
 None
None
ACT  A   1 ( 4.7A)
 0.59A 1x70A-3cghA:
undetectable		 1x70A-3cghA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ci0 PSEUDOPILIN GSPK

(Escherichia
coli) 		PF03934
(T2SSK) 		3 ARG K  30
SER K  44
TYR K  43
 None
 0.74A 1x70A-3ci0K:
4.0		 1x70A-3ci0K:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 ARG A 430
SER A 381
TYR A 380
 None
 0.51A 1x70A-3d7uA:
2.6		 1x70A-3d7uA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehm SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12741
(SusD-like) 		3 ARG A  33
SER A 145
TYR A 143
 None
 0.70A 1x70A-3ehmA:
undetectable		 1x70A-3ehmA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fca CYSTEINE SYNTHASE

(Thermus
thermophilus) 		PF00291
(PALP) 		3 ARG A 223
SER A 141
TYR A 140
 None
 0.61A 1x70A-3fcaA:
undetectable		 1x70A-3fcaA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g0t PUTATIVE
AMINOTRANSFERASE

(Porphyromonas
gingivalis) 		PF00155
(Aminotran_1_2) 		3 ARG A 344
SER A 233
TYR A 232
 None
 0.75A 1x70A-3g0tA:
undetectable		 1x70A-3g0tA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyx ADENYLYLSULFATE
REDUCTASE

(Desulfovibrio
gigas) 		PF00890
(FAD_binding_2)
PF12139
(APS-reductase_C)
PF13187
(Fer4_9) 		3 ARG A 282
SER B  52
TYR B  51
 None
SF4  B1000 ( 4.6A)
None
 0.70A 1x70A-3gyxA:
undetectable		 1x70A-3gyxA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gza PUTATIVE
ALPHA-L-FUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF01120
(Alpha_L_fucos) 		3 ARG A 439
SER A 458
TYR A 457
 None
 0.69A 1x70A-3gzaA:
undetectable		 1x70A-3gzaA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j0h PHIKZ029

(Pseudomonas
virus phiKZ) 		no annotation 3 ARG A 106
SER A 286
TYR A 285
 None
 0.77A 1x70A-3j0hA:
undetectable		 1x70A-3j0hA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j1u CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1, SERYL
T-RNA SYNTHETASE
CHIMERA

(Mus musculus) 		PF12777
(MT) 		3 ARG A3337
SER A3374
TYR A3375
 None
 0.54A 1x70A-3j1uA:
undetectable		 1x70A-3j1uA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l3f PROTEIN DOA1

(Saccharomyces
cerevisiae) 		PF08324
(PUL)
PF09070
(PFU) 		3 ARG X 541
SER X 630
TYR X 629
 None
 0.77A 1x70A-3l3fX:
2.1		 1x70A-3l3fX:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pst PROTEIN DOA1

(Saccharomyces
cerevisiae) 		PF08324
(PUL)
PF09070
(PFU) 		3 ARG A 541
SER A 630
TYR A 629
 None
 0.70A 1x70A-3pstA:
undetectable		 1x70A-3pstA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swv BREFELDIN
A-INHIBITED GUANINE
NUCLEOTIDE-EXCHANGE
PROTEIN 2

(Homo sapiens) 		PF01369
(Sec7) 		3 ARG A 752
SER A 775
TYR A 774
 None
 0.69A 1x70A-3swvA:
undetectable		 1x70A-3swvA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t0o RIBONUCLEASE T2

(Homo sapiens) 		PF00445
(Ribonuclease_T2) 		3 ARG A  94
SER A 130
TYR A 134
 None
 0.71A 1x70A-3t0oA:
undetectable		 1x70A-3t0oA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t7f UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7

(Saccharomyces
cerevisiae) 		PF16420
(ATG7_N) 		3 ARG A  65
SER A 127
TYR A 138
 None
 0.63A 1x70A-3t7fA:
undetectable		 1x70A-3t7fA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tef IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-COMPOUND-BINDIN
G PROTEIN

(Vibrio cholerae) 		PF01497
(Peripla_BP_2) 		3 ARG A  70
SER A 141
TYR A 142
 None
 0.74A 1x70A-3tefA:
undetectable		 1x70A-3tefA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tgl TRIACYL-GLYCEROL
ACYLHYDROLASE

(Rhizomucor
miehei) 		PF01764
(Lipase_3) 		3 ARG A 197
SER A 114
TYR A 115
 None
 0.75A 1x70A-3tglA:
undetectable		 1x70A-3tglA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tmc UNCHARACTERIZED
PROTEIN

(Bdellovibrio
bacteriovorus) 		PF13487
(HD_5) 		3 ARG A  43
SER A  64
TYR A  65
 None
 0.54A 1x70A-3tmcA:
undetectable		 1x70A-3tmcA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u44 ATP-DEPENDENT
HELICASE/NUCLEASE
SUBUNIT A

(Bacillus
subtilis) 		PF00580
(UvrD-helicase)
PF12705
(PDDEXK_1)
PF13361
(UvrD_C) 		3 ARG A 771
SER A 188
TYR A 187
 None
 0.47A 1x70A-3u44A:
undetectable		 1x70A-3u44A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vh1 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7

(Saccharomyces
cerevisiae) 		PF00899
(ThiF)
PF16420
(ATG7_N) 		3 ARG A  65
SER A 127
TYR A 138
 None
 0.65A 1x70A-3vh1A:
undetectable		 1x70A-3vh1A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8j IMPORTIN SUBUNIT
ALPHA-1A

(Oryza sativa) 		PF00514
(Arm)
PF01749
(IBB)
PF16186
(Arm_3) 		3 ARG A  97
SER A  83
TYR A  82
 None
 0.74A 1x70A-4b8jA:
undetectable		 1x70A-4b8jA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bj1 PROTEIN RIF2

(Saccharomyces
cerevisiae) 		no annotation 3 ARG A 353
SER A 308
TYR A 309
 None
 0.59A 1x70A-4bj1A:
undetectable		 1x70A-4bj1A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bpl IMPORTIN SUBUNIT
ALPHA-1A

(Oryza sativa) 		PF00514
(Arm)
PF16186
(Arm_3) 		3 ARG A  97
SER A  83
TYR A  82
 None
 0.75A 1x70A-4bplA:
undetectable		 1x70A-4bplA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bvx EUKARYOTIC
TRANSLATION
ELONGATION FACTOR 1
EPSILON-1
METHIONINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00043
(GST_C) 		3 ARG A   2
SER B 100
TYR B 101
 I3C  A1204 (-3.1A)
None
None
 0.61A 1x70A-4bvxA:
undetectable		 1x70A-4bvxA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4da5 CHOLINE KINASE ALPHA

(Homo sapiens) 		PF01633
(Choline_kinase) 		3 ARG A 367
SER A 355
TYR A 354
 None
None
0H7  A 502 (-3.5A)
 0.60A 1x70A-4da5A:
2.4		 1x70A-4da5A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dkj CYTOSINE-SPECIFIC
METHYLTRANSFERASE

(Mycoplasma
penetrans) 		PF00145
(DNA_methylase) 		3 ARG A 230
SER A  53
TYR A  54
 None
 0.52A 1x70A-4dkjA:
undetectable		 1x70A-4dkjA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euf PUTATIVE REDUCTASE
CA_C0462

(Clostridium
acetobutylicum) 		PF07055
(Eno-Rase_FAD_bd)
PF12241
(Enoyl_reductase)
PF12242
(Eno-Rase_NADH_b) 		3 ARG A 330
SER A 319
TYR A 318
 None
 0.71A 1x70A-4eufA:
undetectable		 1x70A-4eufA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gfj TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24)
PF14520
(HHH_5) 		3 ARG A 112
SER A  99
TYR A 103
 None
 0.78A 1x70A-4gfjA:
undetectable		 1x70A-4gfjA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gvb KP6 KILLER TOXIN
SUBUNIT BETA

(Ustilago maydis
virus P6) 		no annotation 3 ARG B  47
SER B  68
TYR B  67
 None
 0.75A 1x70A-4gvbB:
undetectable		 1x70A-4gvbB:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		3 ARG A 466
SER A 521
TYR A 520
 None
 0.74A 1x70A-4hwtA:
undetectable		 1x70A-4hwtA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4is4 GLUTAMINE SYNTHETASE

(Medicago
truncatula) 		PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N) 		3 ARG A 311
SER A 233
TYR A 132
 None
 0.76A 1x70A-4is4A:
undetectable		 1x70A-4is4A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9a ACYL-COA
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 ARG A 296
SER A  62
TYR A  63
 None
 0.63A 1x70A-4m9aA:
undetectable		 1x70A-4m9aA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n5f PUTATIVE ACYL-COA
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 ARG A 296
SER A  62
TYR A  63
 None
 0.70A 1x70A-4n5fA:
undetectable		 1x70A-4n5fA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4or2 SOLUBLE CYTOCHROME
B562, METABOTROPIC
GLUTAMATE RECEPTOR 1

(Escherichia
coli;
Homo sapiens) 		PF00003
(7tm_3)
PF07361
(Cytochrom_B562) 		3 ARG A 661
SER A 673
TYR A 672
 None
 0.70A 1x70A-4or2A:
undetectable		 1x70A-4or2A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmh PECTINESTERASE

(Sitophilus
oryzae) 		PF01095
(Pectinesterase) 		3 ARG A 194
SER A 214
TYR A 215
 None
 0.77A 1x70A-4pmhA:
undetectable		 1x70A-4pmhA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ql0 FILAMENTOUS
HEMAGGLUTININ
TRANSPORTER PROTEIN
FHAC

(Bordetella
pertussis) 		PF03865
(ShlB)
PF08479
(POTRA_2)
PF17287
(POTRA_3) 		3 ARG A 523
SER A 529
TYR A 528
 None
 0.57A 1x70A-4ql0A:
2.5		 1x70A-4ql0A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0c ABGT PUTATIVE
TRANSPORTER FAMILY

(Alcanivorax
borkumensis) 		PF03806
(ABG_transport) 		3 ARG A 450
SER A 469
TYR A 468
 None
 0.64A 1x70A-4r0cA:
undetectable		 1x70A-4r0cA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r22 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TNRA

(Bacillus
megaterium) 		PF13411
(MerR_1) 		3 ARG B  76
SER B  52
TYR B  51
 None
 0.78A 1x70A-4r22B:
undetectable		 1x70A-4r22B:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r4g PUTATIVE LIPOPROTEIN
YCDA

(Bacillus
subtilis) 		PF11611
(DUF4352)
PF17118
(DUF5105) 		3 ARG A 279
SER A 289
TYR A 288
 None
 0.78A 1x70A-4r4gA:
undetectable		 1x70A-4r4gA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvw ZNUD

(Neisseria
meningitidis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 ARG A 201
SER A  69
TYR A  64
 None
 0.77A 1x70A-4rvwA:
3.4		 1x70A-4rvwA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s0h T-BOX TRANSCRIPTION
FACTOR TBX5

(Homo sapiens) 		PF00907
(T-box) 		3 ARG A 134
SER A  86
TYR A  87
 None
 0.73A 1x70A-4s0hA:
undetectable		 1x70A-4s0hA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ug4 CHOLINE SULFATASE

(Sinorhizobium
meliloti) 		PF00884
(Sulfatase)
PF12411
(Choline_sulf_C) 		3 ARG A 445
SER A 338
TYR A  48
 None
 0.76A 1x70A-4ug4A:
undetectable		 1x70A-4ug4A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4unr THYMIDYLATE KINASE

(Mycobacterium
tuberculosis) 		PF02223
(Thymidylate_kin) 		3 ARG A  38
SER A 104
TYR A 103
 None
QZE  A1211 (-3.3A)
QZE  A1211 (-3.7A)
 0.68A 1x70A-4unrA:
undetectable		 1x70A-4unrA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uwq SOXY PROTEIN
SULFUR OXIDATION
PROTEIN SOXB

(Thermus
thermophilus) 		PF02872
(5_nucleotid_C)
PF13501
(SoxY) 		3 ARG B 117
SER A 173
TYR A 230
 None
 0.77A 1x70A-4uwqB:
undetectable		 1x70A-4uwqB:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		3 ARG A 641
SER A 592
TYR A 591
 None
 0.66A 1x70A-4xi2A:
3.7		 1x70A-4xi2A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xri PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		3 ARG A 430
SER A 350
TYR A 354
 None
 0.74A 1x70A-4xriA:
undetectable		 1x70A-4xriA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		3 ARG A 641
SER A 592
TYR A 591
 None
 0.63A 1x70A-4y93A:
2.0		 1x70A-4y93A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhg GH5

(Bacteroidetes
bacterium AC2a) 		PF00150
(Cellulase) 		3 ARG A 318
SER A 387
TYR A 389
 None
 0.79A 1x70A-4yhgA:
undetectable		 1x70A-4yhgA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdh BETA CHAIN OF JKF6
T-CELL
RECEPTOR,PROTEIN
TRBV28

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 ARG B  14
SER B  65
TYR B  64
 None
 0.75A 1x70A-4zdhB:
undetectable		 1x70A-4zdhB:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxi TYROCIDINE
SYNTHETASE 3

(Acinetobacter
baumannii) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		3 ARG A 973
SER A1082
TYR A1078
 None
 0.70A 1x70A-4zxiA:
2.6		 1x70A-4zxiA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2c FORM II RUBISCO

(Gallionella) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		3 ARG A 243
SER A 214
TYR A 212
 None
 0.69A 1x70A-5c2cA:
undetectable		 1x70A-5c2cA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgt BENZOYLFORMATE
DECARBOXYLASE

(Pseudomonas
putida) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 ARG A 250
SER A 394
TYR A 395
 None
 0.76A 1x70A-5dgtA:
undetectable		 1x70A-5dgtA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF17137
(DUF5110) 		3 ARG A 677
SER A 721
TYR A 720
 None
 0.72A 1x70A-5dkxA:
3.7		 1x70A-5dkxA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dxf TREHALOSE-6-PHOSPHAT
E PHOSPHATASE

(Candida
albicans) 		PF00982
(Glyco_transf_20) 		3 ARG A 142
SER A 378
TYR A 377
 None
 0.53A 1x70A-5dxfA:
2.1		 1x70A-5dxfA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5flv HOMEOBOX PROTEIN
NKX-2.5, T-BOX
TRANSCRIPTION FACTOR
TBX5

(Mus musculus) 		PF00046
(Homeobox)
PF00907
(T-box) 		3 ARG A1134
SER A1086
TYR A1087
 None
 0.65A 1x70A-5flvA:
undetectable		 1x70A-5flvA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 ARG A 831
SER A 899
TYR A 900
 None
 0.67A 1x70A-5j9zA:
2.6		 1x70A-5j9zA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m60 BETA-1,3-GLUCANASE

(Chaetomium
thermophilum) 		PF12708
(Pectate_lyase_3) 		3 ARG A 360
SER A 715
TYR A 714
 None
 0.77A 1x70A-5m60A:
undetectable		 1x70A-5m60A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mtz RIBONUCLEASE Z

(Saccharomyces
cerevisiae) 		PF13691
(Lactamase_B_4) 		3 ARG A 170
SER A 676
TYR A 675
 None
 0.50A 1x70A-5mtzA:
undetectable		 1x70A-5mtzA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nbd NANOBODY

(Lama glama) 		PF07686
(V-set) 		3 ARG C  19
SER C 112
TYR C  95
 None
 0.66A 1x70A-5nbdC:
undetectable		 1x70A-5nbdC:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oas MALATE SYNTHASE G

(Pseudomonas
aeruginosa) 		no annotation 3 ARG A 632
SER A 676
TYR A 677
 None
 0.79A 1x70A-5oasA:
2.5		 1x70A-5oasA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olk RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT 1

(Leeuwenhoekiella
blandensis) 		no annotation 3 ARG A  98
SER A  15
TYR A  14
 DTP  A1002 (-4.6A)
None
None
 0.63A 1x70A-5olkA:
undetectable		 1x70A-5olkA:
6.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5osn CAPSID PROTEIN

(Enterovirus E) 		PF00073
(Rhv) 		3 ARG A 253
SER A 198
TYR A 202
 None
 0.79A 1x70A-5osnA:
undetectable		 1x70A-5osnA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT

(Homo sapiens) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		3 ARG A 256
SER A 373
TYR A 371
 TTP  A1601 (-3.2A)
None
None
 0.68A 1x70A-5tusA:
undetectable		 1x70A-5tusA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhk O-GLCNACASE
TIM-BARREL DOMAIN

(Homo sapiens) 		PF07555
(NAGidase) 		3 ARG A  71
SER A 112
TYR A 111
 None
 0.77A 1x70A-5uhkA:
undetectable		 1x70A-5uhkA:
17.72