SIMILAR PATTERNS OF AMINO ACIDS FOR 1X70_A_715A801

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhy P64K

(Neisseria
meningitidis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLU A 152
VAL A 164
TYR A 251
TYR A 154
VAL A 160
 FAD  A 600 (-2.5A)
None
FAD  A 600 (-4.5A)
FAD  A 600 (-3.7A)
FAD  A 600 (-3.4A)
 1.29A 1x70A-1bhyA:
undetectable		 1x70A-1bhyA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jny ELONGATION FACTOR
1-ALPHA

(Sulfolobus
solfataricus) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		5 TYR A 218
VAL A 151
TYR A 166
TYR A 210
VAL A 170
 None
 1.41A 1x70A-1jnyA:
2.9		 1x70A-1jnyA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE

(Lactococcus
lactis) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C)
PF09168
(PepX_N) 		5 TYR A 210
TYR A 380
ASN A 470
VAL A 471
HIS A 498
 None
 0.53A 1x70A-1lnsA:
7.8		 1x70A-1lnsA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szb MANNOSE BINDING
LECTIN-ASSOCIATED
SERINE PROTEASE-2
RELATED PROTEIN,
MAP19 (19KDA)

(Homo sapiens) 		PF00431
(CUB)
PF07645
(EGF_CA) 		5 GLU A  52
SER A  54
PHE A  61
TYR A  24
ASN A 108
 GLU  A  52 (-0.6A)
SER  A  54 ( 0.0A)
PHE  A  61 ( 1.3A)
TYR  A  24 ( 1.3A)
ASN  A 108 (-0.6A)
 1.05A 1x70A-1szbA:
undetectable		 1x70A-1szbA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t0b THUA-LIKE PROTEIN

(Geobacillus
stearothermophilus) 		PF06283
(ThuA) 		5 GLU A 152
GLU A 128
PHE A 179
VAL A 213
VAL A 210
 None
 1.14A 1x70A-1t0bA:
2.0		 1x70A-1t0bA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
LARGE SUBUNIT

(Pseudomonas
putida) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 ARG B  49
GLU B 287
GLU B 283
VAL B 268
VAL B  45
 None
 1.38A 1x70A-1t3qB:
undetectable		 1x70A-1t3qB:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yb0 PROPHAGE LAMBDABA02,
N-ACETYLMURAMOYL-L-A
LANINE AMIDASE,
FAMILY 2

(Bacillus
anthracis) 		PF01510
(Amidase_2) 		5 GLU A 105
TYR A 101
TYR A 102
ASN A  30
HIS A 139
 None
 1.08A 1x70A-1yb0A:
2.0		 1x70A-1yb0A:
12.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1z68 FIBROBLAST
ACTIVATION PROTEIN,
ALPHA SUBUNIT

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		10 ARG A 123
GLU A 203
GLU A 204
TYR A 541
VAL A 650
TYR A 656
TYR A 660
ASN A 704
VAL A 705
HIS A 734
 None
 0.54A 1x70A-1z68A:
48.8		 1x70A-1z68A:
53.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1z68 FIBROBLAST
ACTIVATION PROTEIN,
ALPHA SUBUNIT

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		7 ARG A 123
GLU A 204
PHE A 351
TYR A 656
ASN A 704
VAL A 705
HIS A 734
 None
 1.46A 1x70A-1z68A:
48.8		 1x70A-1z68A:
53.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1z68 FIBROBLAST
ACTIVATION PROTEIN,
ALPHA SUBUNIT

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		6 ARG A 123
PHE A 350
TYR A 541
VAL A 650
TYR A 660
HIS A 734
 None
 1.03A 1x70A-1z68A:
48.8		 1x70A-1z68A:
53.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2buc DIPEPTIDYL PEPTIDASE
IV

(Sus scrofa) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		12 ARG A 125
GLU A 205
GLU A 206
SER A 209
PHE A 357
TYR A 547
VAL A 656
TYR A 662
TYR A 666
ASN A 710
VAL A 711
HIS A 740
 SO4  A1769 ( 3.1A)
008  A1767 (-3.9A)
008  A1767 (-2.5A)
008  A1767 (-3.4A)
008  A1767 (-3.5A)
SO4  A1769 ( 4.5A)
None
008  A1767 (-4.4A)
008  A1767 (-3.8A)
008  A1767 (-3.0A)
None
SO4  A1769 ( 4.1A)
 0.33A 1x70A-2bucA:
56.4		 1x70A-2bucA:
88.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5l DIPEPTIDYL
AMINOPEPTIDASE IV,
PUTATIVE

(Porphyromonas
gingivalis) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		6 TYR A 518
VAL A 629
TYR A 635
TYR A 639
VAL A 681
HIS A 710
 None
 0.37A 1x70A-2d5lA:
33.1		 1x70A-2d5lA:
26.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ecf DIPEPTIDYL PEPTIDASE
IV

(Stenotrophomonas
maltophilia) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		8 GLU A 207
TYR A 524
VAL A 636
TYR A 642
TYR A 646
ASN A 687
VAL A 688
HIS A 717
 None
 0.66A 1x70A-2ecfA:
35.2		 1x70A-2ecfA:
28.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g1l KINESIN-LIKE PROTEIN
KIF1C

(Homo sapiens) 		PF00498
(FHA)
PF16183
(Kinesin_assoc) 		5 GLU A 512
SER A 511
VAL A 588
ASN A 505
VAL A 594
 None
 1.48A 1x70A-2g1lA:
2.3		 1x70A-2g1lA:
9.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2g5t DIPEPTIDYL PEPTIDASE
4

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		12 ARG A 125
GLU A 205
GLU A 206
SER A 209
PHE A 357
TYR A 547
VAL A 656
TYR A 662
TYR A 666
ASN A 710
VAL A 711
HIS A 740
 ACF  A 800 (-3.4A)
ACF  A 800 (-3.6A)
ACF  A 800 (-3.2A)
None
None
ACF  A 800 (-4.5A)
None
ACF  A 800 (-4.1A)
ACF  A 800 (-3.3A)
ACF  A 800 (-3.3A)
None
None
 0.26A 1x70A-2g5tA:
58.6		 1x70A-2g5tA:
99.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m3k MINOR PILIN COMP

(Neisseria
meningitidis) 		PF16732
(ComP_DUS) 		5 GLU A  87
SER A  65
TYR A  27
ASN A  86
VAL A  90
 None
 1.27A 1x70A-2m3kA:
undetectable		 1x70A-2m3kA:
10.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2oae DIPEPTIDYL PEPTIDASE
4

(Rattus
norvegicus) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		11 ARG A 123
GLU A 203
GLU A 204
PHE A 355
TYR A 548
VAL A 657
TYR A 663
TYR A 667
ASN A 711
VAL A 712
HIS A 741
 SO4  A 801 ( 3.1A)
AIL  A 901 (-3.8A)
AIL  A 901 (-2.9A)
AIL  A 901 (-3.7A)
SO4  A 801 (-4.3A)
None
AIL  A 901 (-4.3A)
AIL  A 901 (-3.8A)
AIL  A 901 (-3.1A)
AIL  A 901 (-4.9A)
SO4  A 801 (-4.1A)
 0.37A 1x70A-2oaeA:
52.5		 1x70A-2oaeA:
84.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2oae DIPEPTIDYL PEPTIDASE
4

(Rattus
norvegicus) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		6 GLU A 203
PHE A 355
TYR A 548
VAL A 657
TYR A 663
VAL A 712
 AIL  A 901 (-3.8A)
AIL  A 901 (-3.7A)
SO4  A 801 (-4.3A)
None
AIL  A 901 (-4.3A)
AIL  A 901 (-4.9A)
 1.36A 1x70A-2oaeA:
52.5		 1x70A-2oaeA:
84.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pl5 HOMOSERINE
O-ACETYLTRANSFERASE

(Leptospira
interrogans) 		PF00561
(Abhydrolase_1) 		5 GLU A 337
SER A 340
VAL A 323
TYR A 335
VAL A 305
 None
 1.43A 1x70A-2pl5A:
16.7		 1x70A-2pl5A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rsy PHOSPHOPROTEIN
ASSOCIATED WITH
GLYCOSPHINGOLIPID-EN
RICHED MICRODOMAINS
1
TYROSINE-PROTEIN
KINASE CSK

(Rattus
norvegicus) 		PF00017
(SH2)
PF15347
(PAG) 		5 GLU A 127
SER B 292
TYR A 129
ASN B 318
VAL B 317
 None
 1.45A 1x70A-2rsyA:
undetectable		 1x70A-2rsyA:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		5 ARG G1567
GLU G1199
SER G1566
VAL G1195
VAL G1182
 None
 1.45A 1x70A-2uv8G:
undetectable		 1x70A-2uv8G:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxx DIAMINOPIMELATE
DECARBOXYLASE

(Thermotoga
maritima) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 GLU A 359
TYR A  18
TYR A  16
ASN A  48
VAL A 252
 None
 1.45A 1x70A-2yxxA:
undetectable		 1x70A-2yxxA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z4g HISTIDINOL
PHOSPHATASE

(Thermus
thermophilus) 		PF02811
(PHP)
PF13263
(PHP_C) 		5 ARG A 196
GLU A 230
PHE A 235
TYR A  21
HIS A 226
 None
None
None
None
ZN  A 501 (-3.3A)
 1.40A 1x70A-2z4gA:
undetectable		 1x70A-2z4gA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zie PUTATIVE
MODIFICATION
METHYLASE

(Thermus
thermophilus) 		PF01555
(N6_N4_Mtase) 		5 ARG A  85
GLU A  82
PHE A 128
VAL A 263
VAL A  32
 None
 1.38A 1x70A-2zieA:
undetectable		 1x70A-2zieA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcf TERMINAL OXYGENASE
COMPONENT OF
CARBAZOLE
1,9A-DIOXYGENASE

(Nocardioides
aromaticivorans) 		PF00355
(Rieske)
PF11723
(Aromatic_hydrox) 		5 GLU A 299
PHE A  40
VAL A 338
VAL A 173
HIS A 298
 CL  A 396 ( 4.0A)
None
None
None
None
 1.47A 1x70A-3gcfA:
undetectable		 1x70A-3gcfA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Schizosaccharomyces
pombe) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		5 SER B  29
PHE B  36
TYR B 676
TYR B 530
VAL B 669
 None
 1.48A 1x70A-3h0gB:
undetectable		 1x70A-3h0gB:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ius UNCHARACTERIZED
CONSERVED PROTEIN

(Ruegeria
pomeroyi) 		no annotation 5 SER A 160
VAL A  16
TYR A  12
VAL A 182
HIS A 181
 None
EDO  A 286 (-3.7A)
None
None
None
 1.48A 1x70A-3iusA:
undetectable		 1x70A-3iusA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ix1 N-FORMYL-4-AMINO-5-A
MINOMETHYL-2-METHYLP
YRIMIDINE BINDING
PROTEIN

(Bacillus
halodurans) 		PF09084
(NMT1) 		5 GLU A 192
TYR A  90
ASN A  42
VAL A  44
HIS A  45
 NFM  A 401 (-2.8A)
NFM  A 401 (-3.9A)
NFM  A 401 ( 4.0A)
None
None
 1.30A 1x70A-3ix1A:
undetectable		 1x70A-3ix1A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3moz MYO-INOSITOL
HEXAPHOSPHATE
PHOSPHOHYDROLASE

(Selenomonas
ruminantium) 		PF14566
(PTPlike_phytase) 		5 SER A  73
PHE A 250
TYR A 239
VAL A 323
ASN A 271
 None
None
GOL  A1001 (-4.0A)
None
None
 1.42A 1x70A-3mozA:
undetectable		 1x70A-3mozA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3msv NUCLEAR IMPORT
ADAPTOR, NRO1

(Schizosaccharomyces
pombe) 		PF12753
(Nro1) 		5 SER A 250
VAL A 180
TYR A 241
ASN A 203
VAL A 202
 None
 1.39A 1x70A-3msvA:
undetectable		 1x70A-3msvA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3npg UNCHARACTERIZED
DUF364 FAMILY
PROTEIN

(Pyrococcus
horikoshii) 		PF04016
(DUF364)
PF13938
(DUF4213) 		5 PHE A 234
VAL A 175
TYR A  31
ASN A  89
VAL A  85
 None
None
ACT  A 251 (-4.2A)
None
None
 1.26A 1x70A-3npgA:
undetectable		 1x70A-3npgA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3npg UNCHARACTERIZED
DUF364 FAMILY
PROTEIN

(Pyrococcus
horikoshii) 		PF04016
(DUF364)
PF13938
(DUF4213) 		5 SER A 241
PHE A 234
VAL A 175
TYR A  31
ASN A  89
 None
None
None
ACT  A 251 (-4.2A)
None
 1.35A 1x70A-3npgA:
undetectable		 1x70A-3npgA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qtn UNCHARACTERIZED
PROTEIN C4B3.07

(Schizosaccharomyces
pombe) 		PF12753
(Nro1) 		5 SER B 250
VAL B 180
TYR B 241
ASN B 203
VAL B 202
 None
 1.47A 1x70A-3qtnB:
undetectable		 1x70A-3qtnB:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rh7 HYPOTHETICAL
OXIDOREDUCTASE

(Sinorhizobium
meliloti) 		PF01613
(Flavin_Reduct) 		5 GLU A 283
SER A 285
VAL A 242
TYR A 228
VAL A 179
 None
 1.48A 1x70A-3rh7A:
undetectable		 1x70A-3rh7A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rze HISTAMINE H1
RECEPTOR, LYSOZYME
CHIMERA

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 PHE A 435
VAL A  76
TYR A 458
ASN A  84
VAL A  80
 D7V  A1201 ( 3.8A)
None
5EH  A1200 ( 4.4A)
None
None
 1.43A 1x70A-3rzeA:
undetectable		 1x70A-3rzeA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9h ACRIFLAVINE
RESISTANCE PROTEIN B

(Escherichia
coli) 		PF00873
(ACR_tran) 		5 SER A 656
VAL A 606
TYR A 598
TYR A 597
VAL A 629
 None
 1.40A 1x70A-3w9hA:
undetectable		 1x70A-3w9hA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhz BETA-GLUCURONIDASE

(Escherichia
coli) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		5 ARG A 327
GLU A 504
PHE A 164
ASN A 466
VAL A 446
 None
 1.36A 1x70A-4jhzA:
undetectable		 1x70A-4jhzA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV

(Bacteroides
ovatus) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		5 TYR A 518
VAL A 629
TYR A 635
TYR A 639
HIS A 710
 PEG  A 801 ( 4.0A)
None
None
None
None
 0.34A 1x70A-4q1vA:
35.7		 1x70A-4q1vA:
28.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvv TYROSINE PHOSPHATASE
II SUPERFAMILY
PROTEIN

(Legionella
pneumophila) 		PF14566
(PTPlike_phytase) 		5 TYR A 115
VAL A 188
TYR A 195
VAL A 105
HIS A 230
 None
 1.42A 1x70A-4tvvA:
undetectable		 1x70A-4tvvA:
18.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wjl INACTIVE DIPEPTIDYL
PEPTIDASE 10

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		5 GLU A 233
GLU A 234
TYR A 683
VAL A 730
HIS A 759
 None
 0.75A 1x70A-4wjlA:
41.3		 1x70A-4wjlA:
36.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE

(Bacillus
licheniformis) 		PF01019
(G_glu_transpept) 		5 GLU A 110
SER A 108
VAL A 249
ASN A 436
VAL A 141
 None
 1.41A 1x70A-4y23A:
undetectable		 1x70A-4y23A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c70 GLUCURONIDASE

(Aspergillus
oryzae) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		5 ARG A 329
GLU A 505
PHE A 163
ASN A 467
VAL A 447
 None
 1.48A 1x70A-5c70A:
undetectable		 1x70A-5c70A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ckm MANNAN-BINDING
LECTIN SERINE
PEPTIDASE 2

(Rattus
norvegicus) 		PF00431
(CUB)
PF07645
(EGF_CA) 		5 GLU A  48
SER A  50
PHE A  57
TYR A  20
ASN A 104
 CA  A 301 (-3.2A)
None
None
None
CA  A 301 (-3.0A)
 1.07A 1x70A-5ckmA:
undetectable		 1x70A-5ckmA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dxf TREHALOSE-6-PHOSPHAT
E PHOSPHATASE

(Candida
albicans) 		PF00982
(Glyco_transf_20) 		5 ARG A 339
GLU A 153
TYR A 206
TYR A 207
VAL A 230
 None
 1.50A 1x70A-5dxfA:
undetectable		 1x70A-5dxfA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eno MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB

(Escherichia
coli) 		PF00873
(ACR_tran) 		5 SER A 656
VAL A 606
TYR A 598
TYR A 597
VAL A 629
 None
 1.37A 1x70A-5enoA:
undetectable		 1x70A-5enoA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvv GLYCOSYL TRANSFERASE
FAMILY 8

(Streptococcus
pneumoniae) 		PF01501
(Glyco_transf_8) 		5 TYR A 309
VAL A 340
TYR A 346
ASN A 282
VAL A 281
 None
 1.09A 1x70A-5gvvA:
undetectable		 1x70A-5gvvA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m59 PRE-MRNA SPLICING
HELICASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		5 ARG A 682
GLU A 954
SER A 681
TYR A1041
VAL A 956
 None
 1.01A 1x70A-5m59A:
undetectable		 1x70A-5m59A:
17.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5olj DIPEPTIDYL PEPTIDASE
IV

(Porphyromonas
gingivalis) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		10 ARG A 115
GLU A 195
GLU A 196
TYR A 511
VAL A 619
TYR A 625
TYR A 629
ASN A 670
VAL A 671
HIS A 700
 GOL  A 801 ( 4.4A)
GOL  A 801 ( 4.6A)
None
GOL  A 801 (-4.4A)
None
GOL  A 801 (-4.5A)
GOL  A 801 ( 4.1A)
GOL  A 801 ( 3.6A)
None
None
 0.39A 1x70A-5oljA:
40.0		 1x70A-5oljA:
32.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u25 DIHYDROLIPOAMIDE
DEHYDROGENASE (E3
COMPONENT OF
PYRUVATE AND
2-OXOGLUTARATE
DEHYDROGENASE
COMPLEXES)

(Neisseria
gonorrhoeae) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLU A 147
VAL A 159
TYR A 246
TYR A 149
VAL A 155
 FAD  A 601 (-2.8A)
None
FAD  A 601 (-4.9A)
FAD  A 601 (-4.1A)
FAD  A 601 (-3.8A)
 1.29A 1x70A-5u25A:
undetectable		 1x70A-5u25A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1

(Schizosaccharomyces
pombe) 		PF00899
(ThiF)
PF09358
(E1_UFD)
PF10585
(UBA_e1_thiolCys)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		5 GLU A 558
SER A 581
VAL A 513
ASN A 534
VAL A 433
 None
 1.43A 1x70A-5um6A:
2.0		 1x70A-5um6A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4

(Pseudoxanthomonas
mexicana) 		no annotation 9 ARG A 106
GLU A 208
GLU A 209
TYR A 527
VAL A 639
TYR A 645
TYR A 649
ASN A 691
VAL A 692
 ILE  A 801 (-4.2A)
ILE  A 801 (-3.4A)
ILE  A 801 (-2.7A)
PRO  A 802 (-4.7A)
None
PRO  A 802 (-4.0A)
PRO  A 802 (-3.8A)
ILE  A 801 (-3.1A)
None
 0.75A 1x70A-5yp3A:
34.6		 1x70A-5yp3A:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4

(Pseudoxanthomonas
mexicana) 		no annotation 9 GLU A 208
GLU A 209
TYR A 527
VAL A 639
TYR A 645
TYR A 649
ASN A 691
VAL A 692
HIS A 721
 ILE  A 801 (-3.4A)
ILE  A 801 (-2.7A)
PRO  A 802 (-4.7A)
None
PRO  A 802 (-4.0A)
PRO  A 802 (-3.8A)
ILE  A 801 (-3.1A)
None
ILE  A 801 (-4.5A)
 0.42A 1x70A-5yp3A:
34.6		 1x70A-5yp3A:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b9m E3 UBIQUITIN-PROTEIN
LIGASE UHRF1

(Danio rerio;
Homo sapiens) 		no annotation 5 ARG D 649
GLU A 155
SER D 651
TYR A 180
VAL A 143
 None
 1.23A 1x70A-6b9mD:
undetectable		 1x70A-6b9mD:
5.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bo6 -

(-) 		no annotation 5 ARG A 340
GLU A 516
PHE A 173
ASN A 479
VAL A 459
 None
E0V  A 701 (-2.6A)
None
E0V  A 701 ( 4.7A)
None
 1.40A 1x70A-6bo6A:
undetectable		 1x70A-6bo6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d8w HEMAGGLUTININ

(Influenza A
virus) 		no annotation 5 GLU A  96
TYR A 232
ASN A 230
VAL A 181
HIS A 183
 None
 1.11A 1x70A-6d8wA:
undetectable		 1x70A-6d8wA:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoq DIPEPTIDYL PEPTIDASE
9

(Homo sapiens) 		no annotation 8 GLU A 249
TYR A 644
VAL A 756
TYR A 762
TYR A 766
ASN A 810
VAL A 811
HIS A 840
 None
 0.52A 1x70A-6eoqA:
undetectable		 1x70A-6eoqA:
6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eot DIPEPTIDYL PEPTIDASE
8

(Homo sapiens) 		no annotation 10 ARG A 160
GLU A 275
GLU A 276
TYR A 669
VAL A 781
TYR A 787
TYR A 791
ASN A 835
VAL A 836
HIS A 865
 None
 0.63A 1x70A-6eotA:
undetectable		 1x70A-6eotA:
7.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cjb PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)

(Plasmodium
falciparum) 		PF00156
(Pribosyltran) 		3 ARG A  53
SER A  97
TYR A  96
 None
 0.78A 1x70A-1cjbA:
undetectable		 1x70A-1cjbA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1evl THREONYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		3 ARG A 354
SER A 409
TYR A 408
 None
 0.45A 1x70A-1evlA:
0.0		 1x70A-1evlA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f56 PLANTACYANIN

(Spinacia
oleracea) 		PF02298
(Cu_bind_like) 		3 ARG A  54
SER A  46
TYR A  44
 None
 0.59A 1x70A-1f56A:
undetectable		 1x70A-1f56A:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		3 ARG A 430
SER A 381
TYR A 380
 None
 0.51A 1x70A-1k9aA:
2.1		 1x70A-1k9aA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lf9 GLUCOAMYLASE

(Thermoanaerobacterium
thermosaccharolyticum) 		PF00723
(Glyco_hydro_15)
PF09137
(Glucodextran_N) 		3 ARG A 407
SER A 416
TYR A 414
 None
 0.74A 1x70A-1lf9A:
1.4		 1x70A-1lf9A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lgy TRIACYLGLYCEROL
LIPASE

(Rhizopus niveus) 		PF01764
(Lipase_3) 		3 ARG A 198
SER A 115
TYR A 116
 None
 0.66A 1x70A-1lgyA:
5.0		 1x70A-1lgyA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oqc AUGMENTER OF LIVER
REGENERATION

(Rattus
norvegicus) 		PF04777
(Evr1_Alr) 		3 ARG A  99
SER A  57
TYR A  60
 None
None
FAD  A 126 (-4.2A)
 0.77A 1x70A-1oqcA:
undetectable		 1x70A-1oqcA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q33 ADP-RIBOSE
PYROPHOSPHATASE

(Homo sapiens) 		PF00293
(NUDIX) 		3 ARG A 148
SER A  68
TYR A  70
 None
 0.67A 1x70A-1q33A:
0.0		 1x70A-1q33A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		3 ARG A 114
SER A 149
TYR A 148
 None
 0.54A 1x70A-1q5aA:
undetectable		 1x70A-1q5aA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qf6 THREONYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF00587
(tRNA-synt_2b)
PF02824
(TGS)
PF03129
(HGTP_anticodon)
PF07973
(tRNA_SAD) 		3 ARG A 354
SER A 409
TYR A 408
 None
 0.51A 1x70A-1qf6A:
0.1		 1x70A-1qf6A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r5n EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT

(Schizosaccharomyces
pombe) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3) 		3 ARG A 317
SER A 450
TYR A 454
 None
 0.75A 1x70A-1r5nA:
undetectable		 1x70A-1r5nA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rkx CDP-GLUCOSE-4,6-DEHY
DRATASE

(Yersinia
pseudotuberculosis) 		PF16363
(GDP_Man_Dehyd) 		3 ARG A  94
SER A 105
TYR A 104
 None
 0.72A 1x70A-1rkxA:
undetectable		 1x70A-1rkxA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rkx CDP-GLUCOSE-4,6-DEHY
DRATASE

(Yersinia
pseudotuberculosis) 		PF16363
(GDP_Man_Dehyd) 		3 ARG A 224
SER A  98
TYR A  97
 None
 0.75A 1x70A-1rkxA:
undetectable		 1x70A-1rkxA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkm CONSERVED
HYPOTHETICAL PROTEIN
TM1464

(Thermotoga
maritima) 		PF04227
(Indigoidine_A) 		3 ARG A 170
SER A 201
TYR A 199
 None
 0.78A 1x70A-1vkmA:
3.1		 1x70A-1vkmA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x4o SPLICING FACTOR 4

(Mus musculus) 		PF01805
(Surp) 		3 ARG A  26
SER A  57
TYR A  60
 None
 0.61A 1x70A-1x4oA:
undetectable		 1x70A-1x4oA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xc6 BETA-GALACTOSIDASE

(Penicillium sp.) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		3 ARG A 134
SER A 591
TYR A 590
 None
 0.72A 1x70A-1xc6A:
1.4		 1x70A-1xc6A:
20.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2buc DIPEPTIDYL PEPTIDASE
IV

(Sus scrofa) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		3 ARG A 358
SER A 630
TYR A 631
 008  A1767 ( 4.0A)
SO4  A1769 ( 3.0A)
None
 0.68A 1x70A-2bucA:
56.4		 1x70A-2bucA:
88.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c60 HUMAN
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 3
ISOFORM 2

(Homo sapiens) 		PF00564
(PB1) 		3 ARG A  56
SER A  91
TYR A  85
 None
 0.77A 1x70A-2c60A:
undetectable		 1x70A-2c60A:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cq1 PTB-LIKE PROTEIN L

(Homo sapiens) 		no annotation 3 ARG A  59
SER A 115
TYR A 114
 None
 0.60A 1x70A-2cq1A:
undetectable		 1x70A-2cq1A:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e18 NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Pyrococcus
horikoshii) 		PF02540
(NAD_synthase) 		3 ARG A 167
SER A 196
TYR A 197
 None
 0.78A 1x70A-2e18A:
2.4		 1x70A-2e18A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eob 1-PHOSPHATIDYLINOSIT
OL-4,5-BISPHOSPHATE
PHOSPHODIESTERASE
GAMMA 2

(Rattus
norvegicus) 		PF00017
(SH2) 		3 ARG A  47
SER A 119
TYR A 118
 None
 0.75A 1x70A-2eobA:
undetectable		 1x70A-2eobA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f4o PEPTIDE N-GLYCANASE

(Mus musculus) 		PF01841
(Transglut_core) 		3 ARG A 408
SER A 389
TYR A 388
 None
 0.70A 1x70A-2f4oA:
undetectable		 1x70A-2f4oA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fja ADENYLYLSULFATE
REDUCTASE, SUBUNIT A
ADENYLYLSULFATE
REDUCTASE, SUBUNIT B

(Archaeoglobus
fulgidus) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C)
PF12139
(APS-reductase_C)
PF13187
(Fer4_9) 		3 ARG A 265
SER B 752
TYR B 751
 None
SF4  B1100 ( 4.5A)
None
 0.46A 1x70A-2fjaA:
undetectable		 1x70A-2fjaA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuj CONSERVED
HYPOTHETICAL PROTEIN

(Xanthomonas
campestris) 		PF13279
(4HBT_2) 		3 ARG A  17
SER A 106
TYR A 105
 None
 0.78A 1x70A-2fujA:
undetectable		 1x70A-2fujA:
10.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2g5t DIPEPTIDYL PEPTIDASE
4

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		3 ARG A 358
SER A 630
TYR A 631
 None
ACF  A 800 (-1.3A)
None
 0.76A 1x70A-2g5tA:
58.6		 1x70A-2g5tA:
99.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gbx BIPHENYL
2,3-DIOXYGENASE
ALPHA SUBUNIT

(Sphingobium
yanoikuyae) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		3 ARG A 286
SER A 156
TYR A 160
 None
 0.76A 1x70A-2gbxA:
undetectable		 1x70A-2gbxA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n1k FIBRONECTIN

(Homo sapiens) 		PF00041
(fn3) 		3 ARG A  29
SER A  88
TYR A  80
 None
 0.67A 1x70A-2n1kA:
undetectable		 1x70A-2n1kA:
9.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2oae DIPEPTIDYL PEPTIDASE
4

(Rattus
norvegicus) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		3 ARG A 356
SER A 631
TYR A 632
 AIL  A 901 ( 4.7A)
AIL  A 901 ( 2.8A)
None
 0.76A 1x70A-2oaeA:
52.5		 1x70A-2oaeA:
84.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odr PHOSPHOSERYL-TRNA
SYNTHETASE

(Methanococcus
maripaludis) 		PF01409
(tRNA-synt_2d) 		3 ARG B  76
SER B 302
TYR B 273
 None
 0.76A 1x70A-2odrB:
undetectable		 1x70A-2odrB:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okx RHAMNOSIDASE B

(Bacillus sp.
GL1) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		3 ARG A 447
SER A 496
TYR A 497
 GOL  A3035 (-3.0A)
None
GOL  A3002 (-4.7A)
 0.70A 1x70A-2okxA:
undetectable		 1x70A-2okxA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2w CITRATE SYNTHASE

(Thermotoga
maritima) 		PF00285
(Citrate_synt) 		3 ARG A 325
SER A  99
TYR A 196
 FLC  A 401 ( 3.1A)
None
None
 0.67A 1x70A-2p2wA:
undetectable		 1x70A-2p2wA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vt1 SURFACE PRESENTATION
OF ANTIGENS PROTEIN
SPAS

(Shigella
flexneri) 		PF01312
(Bac_export_2) 		3 ARG B 290
SER B 318
TYR B 317
 None
 0.75A 1x70A-2vt1B:
undetectable		 1x70A-2vt1B:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT

(Homo sapiens) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC) 		3 ARG A 256
SER A 373
TYR A 371
 DTP  A1745 (-3.0A)
None
None
 0.58A 1x70A-2wghA:
2.2		 1x70A-2wghA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zk7 GLUCOSE
1-DEHYDROGENASE
RELATED PROTEIN

(Thermoplasma
acidophilum) 		PF13561
(adh_short_C2) 		3 ARG A  26
SER A  73
TYR A  71
 None
 0.58A 1x70A-2zk7A:
4.2		 1x70A-2zk7A:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3anp TRANSCRIPTIONAL
REPRESSOR, TETR
FAMILY

(Thermus
thermophilus) 		no annotation 3 ARG C  13
SER C  62
TYR C  60
 None
 0.78A 1x70A-3anpC:
undetectable		 1x70A-3anpC:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b46 AMINOTRANSFERASE
BNA3

(Saccharomyces
cerevisiae) 		PF00155
(Aminotran_1_2) 		3 ARG A  94
SER A 106
TYR A 105
 None
 0.58A 1x70A-3b46A:
undetectable		 1x70A-3b46A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgh SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12741
(SusD-like) 		3 ARG A 100
SER A 114
TYR A 113
 None
None
ACT  A   1 ( 4.7A)
 0.59A 1x70A-3cghA:
undetectable		 1x70A-3cghA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ci0 PSEUDOPILIN GSPK

(Escherichia
coli) 		PF03934
(T2SSK) 		3 ARG K  30
SER K  44
TYR K  43
 None
 0.74A 1x70A-3ci0K:
4.0		 1x70A-3ci0K:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 ARG A 430
SER A 381
TYR A 380
 None
 0.51A 1x70A-3d7uA:
2.6		 1x70A-3d7uA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehm SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12741
(SusD-like) 		3 ARG A  33
SER A 145
TYR A 143
 None
 0.70A 1x70A-3ehmA:
undetectable		 1x70A-3ehmA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fca CYSTEINE SYNTHASE

(Thermus
thermophilus) 		PF00291
(PALP) 		3 ARG A 223
SER A 141
TYR A 140
 None
 0.61A 1x70A-3fcaA:
undetectable		 1x70A-3fcaA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g0t PUTATIVE
AMINOTRANSFERASE

(Porphyromonas
gingivalis) 		PF00155
(Aminotran_1_2) 		3 ARG A 344
SER A 233
TYR A 232
 None
 0.75A 1x70A-3g0tA:
undetectable		 1x70A-3g0tA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyx ADENYLYLSULFATE
REDUCTASE

(Desulfovibrio
gigas) 		PF00890
(FAD_binding_2)
PF12139
(APS-reductase_C)
PF13187
(Fer4_9) 		3 ARG A 282
SER B  52
TYR B  51
 None
SF4  B1000 ( 4.6A)
None
 0.70A 1x70A-3gyxA:
undetectable		 1x70A-3gyxA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gza PUTATIVE
ALPHA-L-FUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF01120
(Alpha_L_fucos) 		3 ARG A 439
SER A 458
TYR A 457
 None
 0.69A 1x70A-3gzaA:
undetectable		 1x70A-3gzaA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j0h PHIKZ029

(Pseudomonas
virus phiKZ) 		no annotation 3 ARG A 106
SER A 286
TYR A 285
 None
 0.77A 1x70A-3j0hA:
undetectable		 1x70A-3j0hA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j1u CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1, SERYL
T-RNA SYNTHETASE
CHIMERA

(Mus musculus) 		PF12777
(MT) 		3 ARG A3337
SER A3374
TYR A3375
 None
 0.54A 1x70A-3j1uA:
undetectable		 1x70A-3j1uA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l3f PROTEIN DOA1

(Saccharomyces
cerevisiae) 		PF08324
(PUL)
PF09070
(PFU) 		3 ARG X 541
SER X 630
TYR X 629
 None
 0.77A 1x70A-3l3fX:
2.1		 1x70A-3l3fX:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pst PROTEIN DOA1

(Saccharomyces
cerevisiae) 		PF08324
(PUL)
PF09070
(PFU) 		3 ARG A 541
SER A 630
TYR A 629
 None
 0.70A 1x70A-3pstA:
undetectable		 1x70A-3pstA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swv BREFELDIN
A-INHIBITED GUANINE
NUCLEOTIDE-EXCHANGE
PROTEIN 2

(Homo sapiens) 		PF01369
(Sec7) 		3 ARG A 752
SER A 775
TYR A 774
 None
 0.69A 1x70A-3swvA:
undetectable		 1x70A-3swvA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t0o RIBONUCLEASE T2

(Homo sapiens) 		PF00445
(Ribonuclease_T2) 		3 ARG A  94
SER A 130
TYR A 134
 None
 0.71A 1x70A-3t0oA:
undetectable		 1x70A-3t0oA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t7f UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7

(Saccharomyces
cerevisiae) 		PF16420
(ATG7_N) 		3 ARG A  65
SER A 127
TYR A 138
 None
 0.63A 1x70A-3t7fA:
undetectable		 1x70A-3t7fA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tef IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-COMPOUND-BINDIN
G PROTEIN

(Vibrio cholerae) 		PF01497
(Peripla_BP_2) 		3 ARG A  70
SER A 141
TYR A 142
 None
 0.74A 1x70A-3tefA:
undetectable		 1x70A-3tefA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tgl TRIACYL-GLYCEROL
ACYLHYDROLASE

(Rhizomucor
miehei) 		PF01764
(Lipase_3) 		3 ARG A 197
SER A 114
TYR A 115
 None
 0.75A 1x70A-3tglA:
undetectable		 1x70A-3tglA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tmc UNCHARACTERIZED
PROTEIN

(Bdellovibrio
bacteriovorus) 		PF13487
(HD_5) 		3 ARG A  43
SER A  64
TYR A  65
 None
 0.54A 1x70A-3tmcA:
undetectable		 1x70A-3tmcA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u44 ATP-DEPENDENT
HELICASE/NUCLEASE
SUBUNIT A

(Bacillus
subtilis) 		PF00580
(UvrD-helicase)
PF12705
(PDDEXK_1)
PF13361
(UvrD_C) 		3 ARG A 771
SER A 188
TYR A 187
 None
 0.47A 1x70A-3u44A:
undetectable		 1x70A-3u44A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vh1 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7

(Saccharomyces
cerevisiae) 		PF00899
(ThiF)
PF16420
(ATG7_N) 		3 ARG A  65
SER A 127
TYR A 138
 None
 0.65A 1x70A-3vh1A:
undetectable		 1x70A-3vh1A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8j IMPORTIN SUBUNIT
ALPHA-1A

(Oryza sativa) 		PF00514
(Arm)
PF01749
(IBB)
PF16186
(Arm_3) 		3 ARG A  97
SER A  83
TYR A  82
 None
 0.74A 1x70A-4b8jA:
undetectable		 1x70A-4b8jA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bj1 PROTEIN RIF2

(Saccharomyces
cerevisiae) 		no annotation 3 ARG A 353
SER A 308
TYR A 309
 None
 0.59A 1x70A-4bj1A:
undetectable		 1x70A-4bj1A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bpl IMPORTIN SUBUNIT
ALPHA-1A

(Oryza sativa) 		PF00514
(Arm)
PF16186
(Arm_3) 		3 ARG A  97
SER A  83
TYR A  82
 None
 0.75A 1x70A-4bplA:
undetectable		 1x70A-4bplA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bvx EUKARYOTIC
TRANSLATION
ELONGATION FACTOR 1
EPSILON-1
METHIONINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00043
(GST_C) 		3 ARG A   2
SER B 100
TYR B 101
 I3C  A1204 (-3.1A)
None
None
 0.61A 1x70A-4bvxA:
undetectable		 1x70A-4bvxA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4da5 CHOLINE KINASE ALPHA

(Homo sapiens) 		PF01633
(Choline_kinase) 		3 ARG A 367
SER A 355
TYR A 354
 None
None
0H7  A 502 (-3.5A)
 0.60A 1x70A-4da5A:
2.4		 1x70A-4da5A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dkj CYTOSINE-SPECIFIC
METHYLTRANSFERASE

(Mycoplasma
penetrans) 		PF00145
(DNA_methylase) 		3 ARG A 230
SER A  53
TYR A  54
 None
 0.52A 1x70A-4dkjA:
undetectable		 1x70A-4dkjA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euf PUTATIVE REDUCTASE
CA_C0462

(Clostridium
acetobutylicum) 		PF07055
(Eno-Rase_FAD_bd)
PF12241
(Enoyl_reductase)
PF12242
(Eno-Rase_NADH_b) 		3 ARG A 330
SER A 319
TYR A 318
 None
 0.71A 1x70A-4eufA:
undetectable		 1x70A-4eufA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gfj TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24)
PF14520
(HHH_5) 		3 ARG A 112
SER A  99
TYR A 103
 None
 0.78A 1x70A-4gfjA:
undetectable		 1x70A-4gfjA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gvb KP6 KILLER TOXIN
SUBUNIT BETA

(Ustilago maydis
virus P6) 		no annotation 3 ARG B  47
SER B  68
TYR B  67
 None
 0.75A 1x70A-4gvbB:
undetectable		 1x70A-4gvbB:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		3 ARG A 466
SER A 521
TYR A 520
 None
 0.74A 1x70A-4hwtA:
undetectable		 1x70A-4hwtA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4is4 GLUTAMINE SYNTHETASE

(Medicago
truncatula) 		PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N) 		3 ARG A 311
SER A 233
TYR A 132
 None
 0.76A 1x70A-4is4A:
undetectable		 1x70A-4is4A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9a ACYL-COA
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 ARG A 296
SER A  62
TYR A  63
 None
 0.63A 1x70A-4m9aA:
undetectable		 1x70A-4m9aA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n5f PUTATIVE ACYL-COA
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 ARG A 296
SER A  62
TYR A  63
 None
 0.70A 1x70A-4n5fA:
undetectable		 1x70A-4n5fA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4or2 SOLUBLE CYTOCHROME
B562, METABOTROPIC
GLUTAMATE RECEPTOR 1

(Escherichia
coli;
Homo sapiens) 		PF00003
(7tm_3)
PF07361
(Cytochrom_B562) 		3 ARG A 661
SER A 673
TYR A 672
 None
 0.70A 1x70A-4or2A:
undetectable		 1x70A-4or2A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmh PECTINESTERASE

(Sitophilus
oryzae) 		PF01095
(Pectinesterase) 		3 ARG A 194
SER A 214
TYR A 215
 None
 0.77A 1x70A-4pmhA:
undetectable		 1x70A-4pmhA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ql0 FILAMENTOUS
HEMAGGLUTININ
TRANSPORTER PROTEIN
FHAC

(Bordetella
pertussis) 		PF03865
(ShlB)
PF08479
(POTRA_2)
PF17287
(POTRA_3) 		3 ARG A 523
SER A 529
TYR A 528
 None
 0.57A 1x70A-4ql0A:
2.5		 1x70A-4ql0A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0c ABGT PUTATIVE
TRANSPORTER FAMILY

(Alcanivorax
borkumensis) 		PF03806
(ABG_transport) 		3 ARG A 450
SER A 469
TYR A 468
 None
 0.64A 1x70A-4r0cA:
undetectable		 1x70A-4r0cA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r22 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TNRA

(Bacillus
megaterium) 		PF13411
(MerR_1) 		3 ARG B  76
SER B  52
TYR B  51
 None
 0.78A 1x70A-4r22B:
undetectable		 1x70A-4r22B:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r4g PUTATIVE LIPOPROTEIN
YCDA

(Bacillus
subtilis) 		PF11611
(DUF4352)
PF17118
(DUF5105) 		3 ARG A 279
SER A 289
TYR A 288
 None
 0.78A 1x70A-4r4gA:
undetectable		 1x70A-4r4gA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvw ZNUD

(Neisseria
meningitidis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 ARG A 201
SER A  69
TYR A  64
 None
 0.77A 1x70A-4rvwA:
3.4		 1x70A-4rvwA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s0h T-BOX TRANSCRIPTION
FACTOR TBX5

(Homo sapiens) 		PF00907
(T-box) 		3 ARG A 134
SER A  86
TYR A  87
 None
 0.73A 1x70A-4s0hA:
undetectable		 1x70A-4s0hA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ug4 CHOLINE SULFATASE

(Sinorhizobium
meliloti) 		PF00884
(Sulfatase)
PF12411
(Choline_sulf_C) 		3 ARG A 445
SER A 338
TYR A  48
 None
 0.76A 1x70A-4ug4A:
undetectable		 1x70A-4ug4A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4unr THYMIDYLATE KINASE

(Mycobacterium
tuberculosis) 		PF02223
(Thymidylate_kin) 		3 ARG A  38
SER A 104
TYR A 103
 None
QZE  A1211 (-3.3A)
QZE  A1211 (-3.7A)
 0.68A 1x70A-4unrA:
undetectable		 1x70A-4unrA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uwq SOXY PROTEIN
SULFUR OXIDATION
PROTEIN SOXB

(Thermus
thermophilus) 		PF02872
(5_nucleotid_C)
PF13501
(SoxY) 		3 ARG B 117
SER A 173
TYR A 230
 None
 0.77A 1x70A-4uwqB:
undetectable		 1x70A-4uwqB:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		3 ARG A 641
SER A 592
TYR A 591
 None
 0.66A 1x70A-4xi2A:
3.7		 1x70A-4xi2A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xri PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		3 ARG A 430
SER A 350
TYR A 354
 None
 0.74A 1x70A-4xriA:
undetectable		 1x70A-4xriA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		3 ARG A 641
SER A 592
TYR A 591
 None
 0.63A 1x70A-4y93A:
2.0		 1x70A-4y93A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhg GH5

(Bacteroidetes
bacterium AC2a) 		PF00150
(Cellulase) 		3 ARG A 318
SER A 387
TYR A 389
 None
 0.79A 1x70A-4yhgA:
undetectable		 1x70A-4yhgA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdh BETA CHAIN OF JKF6
T-CELL
RECEPTOR,PROTEIN
TRBV28

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 ARG B  14
SER B  65
TYR B  64
 None
 0.75A 1x70A-4zdhB:
undetectable		 1x70A-4zdhB:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxi TYROCIDINE
SYNTHETASE 3

(Acinetobacter
baumannii) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		3 ARG A 973
SER A1082
TYR A1078
 None
 0.70A 1x70A-4zxiA:
2.6		 1x70A-4zxiA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2c FORM II RUBISCO

(Gallionella) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		3 ARG A 243
SER A 214
TYR A 212
 None
 0.69A 1x70A-5c2cA:
undetectable		 1x70A-5c2cA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgt BENZOYLFORMATE
DECARBOXYLASE

(Pseudomonas
putida) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 ARG A 250
SER A 394
TYR A 395
 None
 0.76A 1x70A-5dgtA:
undetectable		 1x70A-5dgtA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF17137
(DUF5110) 		3 ARG A 677
SER A 721
TYR A 720
 None
 0.72A 1x70A-5dkxA:
3.7		 1x70A-5dkxA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dxf TREHALOSE-6-PHOSPHAT
E PHOSPHATASE

(Candida
albicans) 		PF00982
(Glyco_transf_20) 		3 ARG A 142
SER A 378
TYR A 377
 None
 0.53A 1x70A-5dxfA:
2.1		 1x70A-5dxfA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5flv HOMEOBOX PROTEIN
NKX-2.5, T-BOX
TRANSCRIPTION FACTOR
TBX5

(Mus musculus) 		PF00046
(Homeobox)
PF00907
(T-box) 		3 ARG A1134
SER A1086
TYR A1087
 None
 0.65A 1x70A-5flvA:
undetectable		 1x70A-5flvA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 ARG A 831
SER A 899
TYR A 900
 None
 0.67A 1x70A-5j9zA:
2.6		 1x70A-5j9zA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m60 BETA-1,3-GLUCANASE

(Chaetomium
thermophilum) 		PF12708
(Pectate_lyase_3) 		3 ARG A 360
SER A 715
TYR A 714
 None
 0.77A 1x70A-5m60A:
undetectable		 1x70A-5m60A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mtz RIBONUCLEASE Z

(Saccharomyces
cerevisiae) 		PF13691
(Lactamase_B_4) 		3 ARG A 170
SER A 676
TYR A 675
 None
 0.50A 1x70A-5mtzA:
undetectable		 1x70A-5mtzA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nbd NANOBODY

(Lama glama) 		PF07686
(V-set) 		3 ARG C  19
SER C 112
TYR C  95
 None
 0.66A 1x70A-5nbdC:
undetectable		 1x70A-5nbdC:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oas MALATE SYNTHASE G

(Pseudomonas
aeruginosa) 		no annotation 3 ARG A 632
SER A 676
TYR A 677
 None
 0.79A 1x70A-5oasA:
2.5		 1x70A-5oasA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olk RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT 1

(Leeuwenhoekiella
blandensis) 		no annotation 3 ARG A  98
SER A  15
TYR A  14
 DTP  A1002 (-4.6A)
None
None
 0.63A 1x70A-5olkA:
undetectable		 1x70A-5olkA:
6.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5osn CAPSID PROTEIN

(Enterovirus E) 		PF00073
(Rhv) 		3 ARG A 253
SER A 198
TYR A 202
 None
 0.79A 1x70A-5osnA:
undetectable		 1x70A-5osnA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT

(Homo sapiens) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		3 ARG A 256
SER A 373
TYR A 371
 TTP  A1601 (-3.2A)
None
None
 0.68A 1x70A-5tusA:
undetectable		 1x70A-5tusA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhk O-GLCNACASE
TIM-BARREL DOMAIN

(Homo sapiens) 		PF07555
(NAGidase) 		3 ARG A  71
SER A 112
TYR A 111
 None
 0.77A 1x70A-5uhkA:
undetectable		 1x70A-5uhkA:
17.72