SIMILAR PATTERNS OF AMINO ACIDS FOR 1WYG_A_SALA4005_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ctt CYTIDINE DEAMINASE

(Escherichia
coli) 		PF00383
(dCMP_cyt_deam_1)
PF08211
(dCMP_cyt_deam_2) 		5 LEU A 161
PHE A 165
ALA A 232
ALA A 231
GLU A 138
 None
 1.32A 1wygA-1cttA:
0.0		 1wygA-1cttA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dkp PHYTASE

(Escherichia
coli) 		PF00328
(His_Phos_2) 		5 LEU A 207
SER A 196
PHE A 155
THR A 156
ALA A 252
 None
 1.40A 1wygA-1dkpA:
undetectable		 1wygA-1dkpA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1

(Mus musculus) 		PF01979
(Amidohydro_1) 		5 GLU A 232
SER A 308
THR A 313
ALA A 260
ALA A 261
 None
 1.43A 1wygA-1kcxA:
undetectable		 1wygA-1kcxA:
17.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		10 GLU A 802
LEU A 873
SER A 876
ARG A 880
PHE A 914
PHE A1009
THR A1010
ALA A1078
ALA A1079
GLU A1261
 TEI  A3006 ( 3.2A)
TEI  A3006 (-4.8A)
TEI  A3006 (-3.5A)
TEI  A3006 (-3.5A)
TEI  A3006 (-3.6A)
TEI  A3006 (-4.8A)
TEI  A3006 (-2.8A)
MOS  A3004 (-3.0A)
TEI  A3006 ( 3.8A)
MOS  A3004 ( 3.7A)
 0.45A 1wygA-1n5xA:
44.6		 1wygA-1n5xA:
86.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wvv CHITINASE C

(Streptomyces
griseus) 		PF00182
(Glyco_hydro_19) 		5 LEU A 225
PHE A 140
PHE A  91
ALA A 125
ALA A 137
 None
 1.41A 1wygA-1wvvA:
0.4		 1wygA-1wvvA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xsz GUANINE NUCLEOTIDE
EXCHANGE PROTEIN

(Legionella
pneumophila) 		PF01369
(Sec7) 		5 LEU A 110
SER A 113
PHE A  94
PHE A  76
THR A  77
 None
 0.91A 1wygA-1xszA:
undetectable		 1wygA-1xszA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ydo HMG-COA LYASE

(Bacillus
subtilis) 		PF00682
(HMGL-like) 		5 GLU A  11
LEU A  42
ALA A 234
ALA A 277
GLU A 253
 None
 1.47A 1wygA-1ydoA:
0.0		 1wygA-1ydoA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3i SIMILAR TO
RAD54-LIKE

(Danio rerio) 		PF00176
(SNF2_N)
PF00271
(Helicase_C) 		5 PHE X 272
THR X 271
ALA X 305
ALA X 276
GLU X 277
 None
 1.32A 1wygA-1z3iX:
2.7		 1wygA-1z3iX:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8x PROBABLE RNA
POLYMERASE SIGMA-C
FACTOR

(Mycobacterium
tuberculosis) 		PF08281
(Sigma70_r4_2) 		5 SER A 165
ARG A 166
THR A 162
ALA A 152
GLU A 137
 SO4  A 108 ( 3.8A)
SO4  A 108 (-4.7A)
SO4  A 108 (-3.7A)
None
None
 1.42A 1wygA-2o8xA:
undetectable		 1wygA-2o8xA:
4.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7e COAGULATION FACTOR
VIII

(Homo sapiens) 		PF00754
(F5_F8_type_C)
PF07731
(Cu-oxidase_2) 		5 ARG B1776
PHE B1775
THR B1812
ALA B1702
ALA B1701
 None
 1.27A 1wygA-2r7eB:
undetectable		 1wygA-2r7eB:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w55 XANTHINE
DEHYDROGENASE

(Rhodobacter
capsulatus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		8 LEU B 303
ARG B 310
PHE B 344
PHE B 459
THR B 460
ALA B 528
ALA B 529
GLU B 730
 None
HPA  B1780 (-3.4A)
HPA  B1780 (-3.4A)
HPA  B1780 (-4.8A)
HPA  B1780 (-3.6A)
XAX  B1778 ( 3.2A)
HPA  B1780 ( 3.2A)
XAX  B1778 (-3.3A)
 0.51A 1wygA-2w55B:
48.4		 1wygA-2w55B:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w55 XANTHINE
DEHYDROGENASE

(Rhodobacter
capsulatus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 LEU B 303
PHE B 344
PHE B 459
ALA B 528
GLU B 730
 None
HPA  B1780 (-3.4A)
HPA  B1780 (-4.8A)
XAX  B1778 ( 3.2A)
XAX  B1778 (-3.3A)
 1.48A 1wygA-2w55B:
48.4		 1wygA-2w55B:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdv UNCHARACTERIZED
PROTEIN DUF1234

(Pectobacterium
atrosepticum) 		PF06821
(Ser_hydrolase) 		5 LEU A 123
SER A 152
THR A 129
ALA A  87
ALA A  84
 None
 1.27A 1wygA-3bdvA:
undetectable		 1wygA-3bdvA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ckb SUSD

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB) 		5 GLU A 281
LEU A 267
ARG A 382
PHE A 489
ALA A 439
 None
 1.08A 1wygA-3ckbA:
undetectable		 1wygA-3ckbA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3frk QDTB

(Thermoanaerobacterium
thermosaccharolyticum) 		PF01041
(DegT_DnrJ_EryC1) 		5 LEU A 307
SER A 342
PHE A   5
THR A 284
ALA A 185
 TQP  A 374 (-4.8A)
None
None
None
TQP  A 374 (-3.3A)
 1.37A 1wygA-3frkA:
undetectable		 1wygA-3frkA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gd5 ORNITHINE
CARBAMOYLTRANSFERASE

(Gloeobacter
violaceus) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 LEU A  53
ARG A 110
PHE A  55
THR A  62
ALA A  58
 None
 1.30A 1wygA-3gd5A:
undetectable		 1wygA-3gd5A:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jq1 SUSD SUPERFAMILY
PROTEIN

(Bacteroides
vulgatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 GLU A 264
ARG A 332
PHE A 251
PHE A 449
ALA A 393
 None
 1.44A 1wygA-3jq1A:
undetectable		 1wygA-3jq1A:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ot2 UNCHARACTERIZED
PROTEIN

(Trichormus
variabilis) 		PF05685
(Uma2) 		5 GLU A  67
ARG A  69
THR A  77
ALA A  23
GLU A  19
 None
BU1  A 189 ( 4.2A)
None
EDO  A 197 (-3.5A)
EDO  A 197 ( 3.2A)
 1.44A 1wygA-3ot2A:
undetectable		 1wygA-3ot2A:
9.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		9 GLU C 802
LEU C 873
ARG C 880
PHE C 914
PHE C1009
THR C1010
ALA C1078
ALA C1079
GLU C1261
 RMO  C1317 (-4.4A)
None
None
RMO  C1317 (-3.6A)
None
None
RMO  C1317 (-3.2A)
RMO  C1317 ( 3.6A)
RMO  C1317 (-3.4A)
 0.38A 1wygA-3sr6C:
55.3		 1wygA-3sr6C:
59.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		9 GLU C 802
LEU C 873
SER C 876
ARG C 880
PHE C 914
PHE C1009
ALA C1078
ALA C1079
GLU C1261
 RMO  C1317 (-4.4A)
None
None
None
RMO  C1317 (-3.6A)
None
RMO  C1317 (-3.2A)
RMO  C1317 ( 3.6A)
RMO  C1317 (-3.4A)
 0.35A 1wygA-3sr6C:
55.3		 1wygA-3sr6C:
59.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tix CHROMO
DOMAIN-CONTAINING
PROTEIN 1
UBIQUITIN-LIKE
PROTEIN
SMT3,RNA-INDUCED
TRANSCRIPTIONAL
SILENCING COMPLEX
PROTEIN TAS3

(Saccharomyces
cerevisiae;
Schizosaccharomyces
pombe) 		PF11976
(Rad60-SLD)
no annotation 		5 LEU A  51
ARG A  58
ALA A  65
ALA A  62
GLU B 708
 None
None
CL  A1002 ( 4.3A)
None
None
 1.24A 1wygA-3tixA:
2.2		 1wygA-3tixA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vvl HOMOSERINE
O-ACETYLTRANSFERASE

(Streptomyces
lavendulae) 		PF00561
(Abhydrolase_1) 		5 PHE A  36
THR A  83
ALA A  59
ALA A  60
GLU A  72
 None
 1.20A 1wygA-3vvlA:
undetectable		 1wygA-3vvlA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhy 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Mycobacterium
tuberculosis) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		5 LEU A 131
SER A 130
THR A 113
ALA A 142
ALA A 141
 None
 1.30A 1wygA-3zhyA:
2.5		 1wygA-3zhyA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7p RALF

(Legionella
pneumophila) 		PF01369
(Sec7) 		5 LEU A 110
SER A 113
PHE A  94
PHE A  76
THR A  77
 None
 0.91A 1wygA-4c7pA:
2.4		 1wygA-4c7pA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cns DIHYDROPYRIMIDINASE-
LIKE 3

(Homo sapiens) 		PF01979
(Amidohydro_1) 		5 GLU A 232
SER A 308
THR A 313
ALA A 260
ALA A 261
 None
 1.47A 1wygA-4cnsA:
undetectable		 1wygA-4cnsA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cnt DIHYDROPYRIMIDINASE-
LIKE 3

(Homo sapiens) 		PF01979
(Amidohydro_1) 		5 GLU A 232
SER A 308
THR A 313
ALA A 260
ALA A 261
 None
 1.43A 1wygA-4cntA:
undetectable		 1wygA-4cntA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4djf CORRINOID/IRON-SULFU
R PROTEIN LARGE
SUBUNIT

(Moorella
thermoacetica) 		PF03599
(CdhD)
PF04060
(FeS) 		5 LEU C 211
PHE C 245
THR C 246
ALA C 235
ALA C 241
 None
 1.18A 1wygA-4djfC:
undetectable		 1wygA-4djfC:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fbh PROTEIN SYNTHESIS
INHIBITOR I

(Hordeum vulgare) 		PF00161
(RIP) 		5 LEU A  77
SER A  93
ARG A 148
ALA A 165
ALA A 162
 None
 1.44A 1wygA-4fbhA:
undetectable		 1wygA-4fbhA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fhn NUCLEOPORIN NUP120

(Schizosaccharomyces
pombe) 		PF11715
(Nup160) 		5 LEU B 920
SER B 919
THR B 944
ALA B 953
ALA B 954
 None
 0.77A 1wygA-4fhnB:
undetectable		 1wygA-4fhnB:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1d ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Bradyrhizobium
diazoefficiens) 		PF13416
(SBP_bac_8) 		5 LEU A 328
SER A 330
PHE A 315
ALA A 299
ALA A 314
 None
 0.99A 1wygA-4i1dA:
undetectable		 1wygA-4i1dA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j4w NUCLEOCAPSID

(Punta Toro
phlebovirus) 		PF05733
(Tenui_N) 		5 LEU A 222
SER A 230
PHE A 139
THR A 232
ALA A 167
 None
 1.43A 1wygA-4j4wA:
undetectable		 1wygA-4j4wA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o0l NADPH-DEPENDENT
3-QUINUCLIDINONE
REDUCTASE

(Rhodotorula
mucilaginosa) 		PF13561
(adh_short_C2) 		5 LEU A 107
PHE A 153
PHE A 161
ALA A 145
ALA A 146
 None
 1.48A 1wygA-4o0lA:
undetectable		 1wygA-4o0lA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ogc HNH ENDONUCLEASE
DOMAIN PROTEIN

(Actinomyces
naeslundii) 		PF01844
(HNH) 		5 LEU A 448
SER A 287
PHE A 283
ALA A 428
ALA A 427
 None
 1.16A 1wygA-4ogcA:
undetectable		 1wygA-4ogcA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p1n ATG1 TMIT

(Kluyveromyces
marxianus) 		PF12063
(DUF3543) 		5 SER A 823
ARG A 827
ALA A 760
ALA A 761
GLU A 764
 None
 1.24A 1wygA-4p1nA:
2.4		 1wygA-4p1nA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pch VP1

(Human
polyomavirus 7) 		PF00718
(Polyoma_coat) 		5 GLU A 187
SER A  65
THR A  63
ALA A  73
ALA A  72
 None
 1.35A 1wygA-4pchA:
undetectable		 1wygA-4pchA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tpn PUTATIVE P450-LIKE
PROTEIN

(Streptomyces
scabiei) 		PF00067
(p450) 		5 LEU A 287
SER A 254
THR A 251
ALA A 360
ALA A 359
 None
HEM  A 501 (-3.6A)
HEM  A 501 (-4.0A)
GOL  A 503 (-3.9A)
HEM  A 501 (-3.4A)
 1.42A 1wygA-4tpnA:
0.6		 1wygA-4tpnA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio cholerae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 LEU A  52
SER A  14
THR A 328
ALA A 334
ALA A 335
 None
 1.35A 1wygA-4xoxA:
undetectable		 1wygA-4xoxA:
15.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ysw XANTHINE
DEHYDROGENASE/OXIDAS
E

(Rattus
norvegicus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		10 GLU A 802
LEU A 873
SER A 876
ARG A 880
PHE A 914
PHE A1009
THR A1010
ALA A1078
ALA A1079
GLU A1261
 URC  A3007 (-3.0A)
None
None
URC  A3007 (-3.7A)
URC  A3007 ( 3.4A)
URC  A3007 (-4.6A)
URC  A3007 (-3.5A)
URC  A3007 (-3.5A)
URC  A3007 (-3.4A)
URC  A3007 (-2.9A)
 0.37A 1wygA-4yswA:
45.9		 1wygA-4yswA:
99.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e76 SUSD-LIKE PROTEIN
BACOVA_02651

(Bacteroides
ovatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 GLU A 270
LEU A 260
ARG A 326
PHE A 442
ALA A 388
 None
 1.11A 1wygA-5e76A:
undetectable		 1wygA-5e76A:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gtj DUAL SPECIFICITY
PROTEIN PHOSPHATASE
26

(Homo sapiens) 		PF00782
(DSPc) 		5 LEU A 201
PHE A 130
THR A 161
ALA A 134
ALA A 133
 None
 1.22A 1wygA-5gtjA:
undetectable		 1wygA-5gtjA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iuw ALDEHYDE
DEHYDROGENASE FAMILY
PROTEIN

(Pseudomonas
syringae group
genomosp. 3) 		no annotation 5 LEU A 448
PHE A 277
ALA A 418
ALA A 415
GLU A 416
 None
 1.35A 1wygA-5iuwA:
undetectable		 1wygA-5iuwA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n8o DNA HELICASE I

(Escherichia
coli) 		PF07057
(TraI)
PF08751
(TrwC)
PF13604
(AAA_30) 		5 GLU A1417
LEU A1436
SER A1437
ARG A1438
ALA A1402
 None
 1.42A 1wygA-5n8oA:
2.8		 1wygA-5n8oA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN

(Burkholderia
ambifaria) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 LEU A 266
SER A 199
PHE A 197
ALA A 182
ALA A 212
 None
 1.45A 1wygA-5tnxA:
undetectable		 1wygA-5tnxA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w35 DNA PRIMASE

(Mycobacterium
tuberculosis) 		no annotation 5 LEU A 169
SER A 189
PHE A 178
ALA A 123
ALA A 120
 None
 1.34A 1wygA-5w35A:
undetectable		 1wygA-5w35A:
6.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjv DUAL SPECIFICITY
PROTEIN PHOSPHATASE
13 ISOFORM A

(Homo sapiens) 		no annotation 5 LEU A 178
PHE A 107
THR A 138
ALA A 111
ALA A 110
 None
 1.24A 1wygA-5xjvA:
undetectable		 1wygA-5xjvA:
5.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gk6 -

(-) 		no annotation 5 GLU A 287
LEU A 258
SER A 261
THR A 384
ALA A  17
 None
 1.29A 1wygA-6gk6A:
undetectable		 1wygA-6gk6A:
undetectable