SIMILAR PATTERNS OF AMINO ACIDS FOR 1WSV_B_THHB4001_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vf1 GLUTATHIONE
S-TRANSFERASE 3

(Gallus gallus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 ASP A 209
GLU A  36
ARG A 218
TYR A   9
 None
 1.43A 1wsvB-1vf1A:
0.0		 1wsvB-1vf1A:
24.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wop AMINOMETHYLTRANSFERA
SE

(Thermotoga
maritima) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		4 ASP A  96
GLU A 195
ARG A 227
TYR A 168
 FFO  A2887 (-3.1A)
FFO  A2887 (-2.8A)
FFO  A2887 (-3.6A)
None
 1.06A 1wsvB-1wopA:
50.2		 1wsvB-1wopA:
34.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wsv AMINOMETHYLTRANSFERA
SE

(Homo sapiens) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		4 ASP A 101
GLU A 204
ARG A 233
TYR A 371
 ASP  A 101 (-0.6A)
GLU  A 204 (-0.5A)
ARG  A 233 (-0.6A)
TYR  A 371 (-1.3A)
 0.23A 1wsvB-1wsvA:
62.3		 1wsvB-1wsvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gir AMINOMETHYLTRANSFERA
SE

(Bartonella
henselae) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		4 ASP A 108
GLU A 201
ARG A 230
TYR A 369
 None
 0.40A 1wsvB-3girA:
50.1		 1wsvB-3girA:
40.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7p FN1 PROTEIN

(Homo sapiens) 		PF00039
(fn1)
PF00040
(fn2) 		4 ASP A 381
GLU A 377
ARG A 592
TYR A 392
 ZN  A 956 ( 4.4A)
ZN  A 955 ( 4.3A)
None
None
 1.29A 1wsvB-3m7pA:
0.0		 1wsvB-3m7pA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ojy COMPLEMENT COMPONENT
C8 ALPHA CHAIN
COMPLEMENT COMPONENT
C8 BETA CHAIN

(Homo sapiens;
Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00090
(TSP_1)
PF01823
(MACPF)
PF00057
(Ldl_recept_a)
PF00090
(TSP_1)
PF01823
(MACPF) 		4 ASP A  90
GLU A 108
ARG A 177
TYR B 261
 CA  A 555 (-3.4A)
None
None
None
 1.29A 1wsvB-3ojyA:
0.0		 1wsvB-3ojyA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdi NITROGENASE MOFE
COFACTOR
BIOSYNTHESIS PROTEIN
NIFE
NITROGENASE MOFE
COFACTOR
BIOSYNTHESIS PROTEIN
NIFN

(Azotobacter
vinelandii;
Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro)
PF00148
(Oxidored_nitro) 		4 ASP A  40
GLU A 420
ARG B  54
TYR A  80
 None
 1.46A 1wsvB-3pdiA:
0.0		 1wsvB-3pdiA:
23.25