SIMILAR PATTERNS OF AMINO ACIDS FOR 1WSV_B_THHB4001_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cmo POLYOMAVIRUS
ENHANCER BINDING
PROTEIN 2

(Homo sapiens) 		PF00853
(Runt) 		5 MET A 124
THR A 161
ILE A 150
VAL A 103
LEU A  71
 None
 1.33A 1wsvB-1cmoA:
undetectable		 1wsvB-1cmoA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e43 ALPHA-AMYLASE

(Bacillus
amyloliquefaciens) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 THR A 429
LEU A 346
ILE A 428
MET A 304
TRP A 342
 None
 1.35A 1wsvB-1e43A:
0.0		 1wsvB-1e43A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0v PROTEINASE A

(Saccharomyces
cerevisiae) 		PF00026
(Asp) 		5 THR A 268
LEU A 258
ILE A 269
PHE A 262
LEU A 223
 None
 1.17A 1wsvB-1g0vA:
0.0		 1wsvB-1g0vA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyc LACCASE 2

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 THR A 144
ILE A 188
VAL A 187
PHE A 246
LEU A 148
 None
 1.28A 1wsvB-1gycA:
0.0		 1wsvB-1gycA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkq REPLICATION PROTEIN

(Pseudomonas
savastanoi) 		PF01051
(Rep_3) 		5 THR A  47
LEU A 109
ILE A  48
CYH A  29
LEU A  75
 HG  A1133 ( 4.8A)
None
None
HG  A1135 (-2.3A)
None
 1.36A 1wsvB-1hkqA:
undetectable		 1wsvB-1hkqA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j08 GLUTAREDOXIN-LIKE
PROTEIN

(Pyrococcus
horikoshii) 		PF00085
(Thioredoxin)
PF13192
(Thioredoxin_3) 		5 LEU A  26
ILE A  84
VAL A  93
PHE A  17
LEU A  44
 None
 1.25A 1wsvB-1j08A:
undetectable		 1wsvB-1j08A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kya LACCASE

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 THR A 144
ILE A 188
VAL A 187
PHE A 246
LEU A 148
 None
 1.26A 1wsvB-1kyaA:
0.0		 1wsvB-1kyaA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tkc TRANSKETOLASE

(Saccharomyces
cerevisiae) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 LEU A 243
ILE A 244
VAL A 217
LEU A 155
TRP A 212
 None
 1.31A 1wsvB-1tkcA:
0.0		 1wsvB-1tkcA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v3t LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE/PROSTAGLANDIN
15-KETO REDUCTASE

(Cavia porcellus) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		5 LEU A 164
ILE A 296
VAL A 291
TYR A 130
LEU A 134
 None
 1.19A 1wsvB-1v3tA:
undetectable		 1wsvB-1v3tA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrb PUTATIVE ASPARAGINYL
HYDROXYLASE

(Bacillus
subtilis) 		PF08007
(Cupin_4) 		5 ILE A  13
VAL A  16
MET A 215
LEU A 121
TRP A 113
 None
 1.09A 1wsvB-1vrbA:
1.0		 1wsvB-1vrbA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrb PUTATIVE ASPARAGINYL
HYDROXYLASE

(Bacillus
subtilis) 		PF08007
(Cupin_4) 		5 LEU A   9
ILE A  13
VAL A  16
LEU A 121
TRP A 113
 None
 1.14A 1wsvB-1vrbA:
1.0		 1wsvB-1vrbA:
22.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wop AMINOMETHYLTRANSFERA
SE

(Thermotoga
maritima) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		5 MET A  51
VAL A 110
ASN A 112
TYR A 188
TRP A 256
 FFO  A2887 (-4.6A)
FFO  A2887 (-4.0A)
FFO  A2887 (-3.3A)
FFO  A2887 (-3.5A)
None
 0.55A 1wsvB-1wopA:
50.2		 1wsvB-1wopA:
34.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wsv AMINOMETHYLTRANSFERA
SE

(Homo sapiens) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		11 MET A  56
THR A  87
LEU A  88
ILE A 103
VAL A 115
ASN A 117
PHE A 176
MET A 177
TYR A 197
LEU A 242
TRP A 262
 MET  A  56 (-0.0A)
THR  A  87 ( 0.8A)
LEU  A  88 (-0.6A)
ILE  A 103 (-0.7A)
VAL  A 115 (-0.6A)
ASN  A 117 (-0.6A)
PHE  A 176 (-1.3A)
MET  A 177 (-0.0A)
TYR  A 197 (-1.3A)
LEU  A 242 (-0.6A)
TRP  A 262 ( 0.5A)
 0.19A 1wsvB-1wsvA:
62.3		 1wsvB-1wsvA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2acv TRITERPENE
UDP-GLUCOSYL
TRANSFERASE UGT71G1

(Medicago
truncatula) 		PF00201
(UDPGT) 		5 THR A 375
LEU A 374
VAL A 371
PHE A 283
LEU A 419
 None
 1.29A 1wsvB-2acvA:
undetectable		 1wsvB-2acvA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ado MEDIATOR OF DNA
DAMAGE CHECKPOINT
PROTEIN 1

(Homo sapiens) 		PF16770
(RTT107_BRCT_5) 		5 LEU A2065
ILE A2017
VAL A1935
CYH A2020
TYR A2025
 None
 1.35A 1wsvB-2adoA:
undetectable		 1wsvB-2adoA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c45 ASPARTATE
1-DECARBOXYLASE
PRECURSOR

(Mycobacterium
tuberculosis) 		PF02261
(Asp_decarbox) 		5 THR A  45
LEU A  55
ILE A  46
VAL A  85
ASN A  51
 None
 1.21A 1wsvB-2c45A:
undetectable		 1wsvB-2c45A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ej5 ENOYL-COA HYDRATASE
SUBUNIT II

(Geobacillus
kaustophilus) 		PF00378
(ECH_1) 		5 THR A  19
LEU A  18
VAL A  15
PHE A  62
LEU A  92
 None
 1.32A 1wsvB-2ej5A:
undetectable		 1wsvB-2ej5A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz7 GLUTAMINYL-TRNA
SYNTHETASE

(Deinococcus
radiodurans) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C) 		5 THR A 495
LEU A 496
ILE A 476
VAL A 468
LEU A 440
 None
 0.77A 1wsvB-2hz7A:
undetectable		 1wsvB-2hz7A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzh LACCASE

(Trametes
ochracea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 THR A 144
ILE A 188
VAL A 187
PHE A 246
LEU A 148
 None
 1.29A 1wsvB-2hzhA:
undetectable		 1wsvB-2hzhA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inv INSULIN
FRUCTOTRANSFERASE

(Bacillus sp.
snu-7) 		no annotation 5 THR A 216
ILE A 215
ASN A 210
PHE A 183
MET A 218
 None
 1.26A 1wsvB-2invA:
undetectable		 1wsvB-2invA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ldx APO-LACTATE
DEHYDROGENASE

(Mus musculus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 THR A 300
ILE A 299
VAL A 154
CYH A 292
LEU A 258
 None
 1.25A 1wsvB-2ldxA:
undetectable		 1wsvB-2ldxA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mbx PARVALBUMIN BETA

(Gadus morhua) 		PF13499
(EF-hand_7) 		5 LEU A  87
ILE A  98
PHE A  31
MET A 106
LEU A  78
 None
 1.15A 1wsvB-2mbxA:
undetectable		 1wsvB-2mbxA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o4j VITAMIN D3 RECEPTOR

(Rattus
norvegicus) 		PF00104
(Hormone_recep) 		5 THR A 302
LEU A 305
ILE A 306
VAL A 293
LEU A 389
 None
 1.29A 1wsvB-2o4jA:
undetectable		 1wsvB-2o4jA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obn HYPOTHETICAL PROTEIN

(Trichormus
variabilis) 		PF07755
(DUF1611)
PF17396
(DUF1611_N) 		5 MET A 194
THR A 111
LEU A 109
VAL A 132
LEU A  12
 None
 1.35A 1wsvB-2obnA:
undetectable		 1wsvB-2obnA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjc DIADENOSINE
TETRAPHOSPHATASE,
PUTATIVE

(Trypanosoma
brucei) 		PF00149
(Metallophos) 		5 THR A  49
LEU A  50
ILE A  22
VAL A 235
LEU A  34
 None
 1.23A 1wsvB-2qjcA:
undetectable		 1wsvB-2qjcA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt6 LACCASE

(Lentinus
tigrinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 THR A 144
ILE A 188
VAL A 187
PHE A 246
LEU A 148
 None
 1.31A 1wsvB-2qt6A:
undetectable		 1wsvB-2qt6A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qts ACID-SENSING ION
CHANNEL

(Gallus gallus) 		PF00858
(ASC) 		5 ILE A 250
VAL A  91
ASN A 199
CYH A 276
LEU A  86
 None
 1.12A 1wsvB-2qtsA:
undetectable		 1wsvB-2qtsA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyt 2-DEHYDROPANTOATE
2-REDUCTASE

(Porphyromonas
gingivalis) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		5 THR A 150
LEU A 151
ILE A 149
PHE A  64
TYR A  20
 None
 1.35A 1wsvB-2qytA:
undetectable		 1wsvB-2qytA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v75 NUCLEAR
POLYADENYLATED
RNA-BINDING PROTEIN
NAB2

(Saccharomyces
cerevisiae) 		PF11517
(Nab2) 		5 LEU A  52
ILE A  35
VAL A  36
PHE A  24
TYR A  30
 None
 1.18A 1wsvB-2v75A:
undetectable		 1wsvB-2v75A:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2va0 ABFS
ARABINOFURANOSIDASE
TWO COMPONENT SYSTEM
SENSOR PROTEIN

(Cellvibrio
japonicus) 		no annotation 5 THR A 133
LEU A 134
ILE A 132
ASN A  61
LEU A  95
 CL  A1149 (-4.9A)
None
CL  A1149 ( 4.6A)
None
None
 1.26A 1wsvB-2va0A:
undetectable		 1wsvB-2va0A:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wjs LAMININ SUBUNIT
ALPHA-2

(Mus musculus) 		PF00054
(Laminin_G_1) 		5 THR A2422
LEU A2423
ILE A2432
VAL A2445
PHE A2362
 None
 1.27A 1wsvB-2wjsA:
undetectable		 1wsvB-2wjsA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wjs LAMININ SUBUNIT
ALPHA-2

(Mus musculus) 		PF00054
(Laminin_G_1) 		5 THR A2422
LEU A2423
ILE A2432
VAL A2445
TYR A2398
 None
 1.35A 1wsvB-2wjsA:
undetectable		 1wsvB-2wjsA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyb LACCASE

(Trametes
cinnabarina) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 THR A 144
ILE A 188
VAL A 187
PHE A 246
LEU A 148
 None
 1.28A 1wsvB-2xybA:
undetectable		 1wsvB-2xybA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3a PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT BETA ISOFORM

(Mus musculus) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B) 		5 THR A 330
LEU A 331
ILE A 487
VAL A 451
PHE A 381
 None
 1.16A 1wsvB-2y3aA:
undetectable		 1wsvB-2y3aA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia pestis) 		PF00496
(SBP_bac_5) 		5 THR A 143
LEU A 144
ILE A  76
VAL A  88
LEU A 159
 None
 1.33A 1wsvB-2z23A:
undetectable		 1wsvB-2z23A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2za1 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Plasmodium
falciparum) 		PF00215
(OMPdecase) 		5 MET A 172
ILE A 139
VAL A 146
CYH A 162
LEU A 191
 None
 1.28A 1wsvB-2za1A:
undetectable		 1wsvB-2za1A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zu6 EUKARYOTIC
INITIATION FACTOR
4A-I

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 LEU A 263
ILE A 345
VAL A 344
MET A 375
LEU A 288
 None
 1.18A 1wsvB-2zu6A:
undetectable		 1wsvB-2zu6A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zvw PROLIFERATING CELL
NUCLEAR ANTIGEN 2

(Arabidopsis
thaliana) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		5 THR A  89
LEU A   4
ILE A  90
VAL A  99
LEU A  52
 None
 1.36A 1wsvB-2zvwA:
undetectable		 1wsvB-2zvwA:
22.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3a8k AMINOMETHYLTRANSFERA
SE

(Escherichia
coli) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		6 MET A  51
ILE A  99
VAL A 111
ASN A 113
TYR A 188
TRP A 252
 None
 0.65A 1wsvB-3a8kA:
46.5		 1wsvB-3a8kA:
33.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3azc CYTOCHROME B6-F
COMPLEX IRON-SULFUR
SUBUNIT

(Thermosynechococcus
elongatus) 		PF00355
(Rieske) 		5 THR A 173
VAL A 140
PHE A 171
LEU A 104
TRP A 179
 None
 1.15A 1wsvB-3azcA:
undetectable		 1wsvB-3azcA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8y ENDO-PECTATE LYASE

(Dickeya
chrysanthemi) 		PF03211
(Pectate_lyase) 		5 THR A 292
LEU A 266
ILE A 293
VAL A 308
LEU A 226
 None
 1.29A 1wsvB-3b8yA:
undetectable		 1wsvB-3b8yA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b90 ENDO-PECTATE LYASE

(Dickeya
chrysanthemi) 		PF03211
(Pectate_lyase) 		5 THR A 292
LEU A 266
ILE A 293
VAL A 308
LEU A 226
 None
 1.30A 1wsvB-3b90A:
undetectable		 1wsvB-3b90A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c2g SYS-1 PROTEIN

(Caenorhabditis
elegans) 		no annotation 5 LEU A 673
ILE A 674
VAL A 721
CYH A 678
LEU A 644
 None
 1.21A 1wsvB-3c2gA:
undetectable		 1wsvB-3c2gA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d2l SAM-DEPENDENT
METHYLTRANSFERASE

(Exiguobacterium
sibiricum) 		PF13649
(Methyltransf_25) 		5 THR A 100
ILE A 101
ASN A 107
TYR A 205
TRP A  25
 None
 1.15A 1wsvB-3d2lA:
undetectable		 1wsvB-3d2lA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9k KYNURENINASE

(Homo sapiens) 		PF00266
(Aminotran_5) 		5 THR A 455
LEU A 458
ILE A 457
ASN A 411
PHE A 450
 None
 1.35A 1wsvB-3e9kA:
undetectable		 1wsvB-3e9kA:
22.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gir AMINOMETHYLTRANSFERA
SE

(Bartonella
henselae) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		9 MET A  63
ILE A 110
VAL A 122
ASN A 124
PHE A 177
MET A 178
TYR A 194
LEU A 239
TRP A 259
 None
 0.52A 1wsvB-3girA:
50.1		 1wsvB-3girA:
40.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihm STYRENE
MONOOXYGENASE A

(Pseudomonas
putida) 		no annotation 5 THR A 185
ILE A 196
VAL A 211
ASN A 214
LEU A 358
 None
 1.30A 1wsvB-3ihmA:
undetectable		 1wsvB-3ihmA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iyj MAJOR CAPSID PROTEIN
L1

(Deltapapillomavirus
4) 		no annotation 5 THR F 158
VAL F  68
ASN F 445
PHE F 243
LEU F  73
 None
 1.30A 1wsvB-3iyjF:
undetectable		 1wsvB-3iyjF:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kkd TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		PF00440
(TetR_N) 		5 THR A 200
LEU A 199
ILE A 203
VAL A 138
LEU A 231
 PGE  A 238 ( 4.5A)
None
PGE  A 238 ( 4.6A)
None
None
 1.33A 1wsvB-3kkdA:
undetectable		 1wsvB-3kkdA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ln3 DIHYDRODIOL
DEHYDROGENASE

(Mus musculus) 		PF00248
(Aldo_ket_red) 		5 THR A  83
ILE A 115
VAL A 165
ASN A 167
LEU A 268
 None
None
None
NAD  A 327 (-3.3A)
NAD  A 327 ( 4.4A)
 1.30A 1wsvB-3ln3A:
undetectable		 1wsvB-3ln3A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxm ASPARTATE
CARBAMOYLTRANSFERASE

(Yersinia pestis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 ILE A  96
VAL A 100
PHE A  50
CYH A  48
LEU A 115
 None
 1.14A 1wsvB-3lxmA:
undetectable		 1wsvB-3lxmA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nd0 SLL0855 PROTEIN

(Synechocystis
sp. PCC 6803) 		PF00654
(Voltage_CLC) 		5 THR A 324
LEU A 325
ILE A 326
CYH A 330
TRP A 314
 None
 1.33A 1wsvB-3nd0A:
undetectable		 1wsvB-3nd0A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ovk AMINOPEPTIDASE P,
XAA-PRO DIPEPTIDASE

(Streptococcus
pyogenes) 		PF01321
(Creatinase_N) 		5 THR A  48
ILE A  47
VAL A  45
MET A  16
CYH A  12
 None
 1.32A 1wsvB-3ovkA:
undetectable		 1wsvB-3ovkA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxl LACCASE

(Trametes
hirsuta) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 THR A 144
ILE A 188
VAL A 187
PHE A 246
LEU A 148
 None
 1.31A 1wsvB-3pxlA:
undetectable		 1wsvB-3pxlA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwx HYPOTHETICAL
BACTERIAL OUTER
MEMBRANE PROTEIN

(Bacteroides
fragilis) 		PF13944
(Calycin_like) 		5 THR A 265
ILE A 275
VAL A 169
PHE A 216
LEU A 165
 None
 1.18A 1wsvB-3rwxA:
undetectable		 1wsvB-3rwxA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6w LACCASE

(Steccherinum
ochraceum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 THR A 145
ILE A 191
VAL A 190
PHE A 249
LEU A 149
 None
 1.27A 1wsvB-3t6wA:
undetectable		 1wsvB-3t6wA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbg FATTY ACID-BINDING
PROTEIN, HEART

(Homo sapiens) 		PF00061
(Lipocalin) 		5 THR A  50
LEU A  51
VAL A   1
PHE A  70
LEU A 104
 None
 0.93A 1wsvB-3wbgA:
undetectable		 1wsvB-3wbgA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1b LACCASE

(Lentinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 THR A 165
ILE A 209
VAL A 208
PHE A 267
LEU A 169
 None
 1.29A 1wsvB-3x1bA:
undetectable		 1wsvB-3x1bA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aq9 ACETYLCHOLINE
RECEPTOR GAMMA
SUBUNIT

(Torpedo
marmorata) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		5 THR E  50
LEU E  49
VAL E  95
ASN E  93
LEU E 212
 None
 1.33A 1wsvB-4aq9E:
undetectable		 1wsvB-4aq9E:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus musculus) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd) 		5 THR A 330
LEU A 331
ILE A 487
VAL A 451
PHE A 381
 None
 1.08A 1wsvB-4bfrA:
undetectable		 1wsvB-4bfrA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d72 GLYCOSIDE HYDROLASE

(Streptococcus
pneumoniae) 		PF08306
(Glyco_hydro_98M)
PF08307
(Glyco_hydro_98C) 		5 THR A 520
LEU A 519
ILE A 518
VAL A 475
ASN A 550
 None
 1.20A 1wsvB-4d72A:
undetectable		 1wsvB-4d72A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1g MATRIX PROTEIN

(Avian
avulavirus 1) 		PF00661
(Matrix) 		5 THR A  60
ILE A  59
VAL A  97
ASN A  99
CYH A 110
 None
 1.01A 1wsvB-4g1gA:
0.8		 1wsvB-4g1gA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6n UBIQUITIN
CARBOXYL-HYDROLASE

(Trichinella
spiralis) 		PF01088
(Peptidase_C12) 		5 THR A 128
LEU A 127
ILE A 133
VAL A 136
LEU A  95
 None
 1.31A 1wsvB-4i6nA:
undetectable		 1wsvB-4i6nA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ig7 UBIQUITIN C-TERMINAL
HYDROLASE 37

(Trichinella
spiralis) 		PF01088
(Peptidase_C12) 		5 THR A 128
LEU A 127
ILE A 133
VAL A 136
LEU A  95
 None
 1.25A 1wsvB-4ig7A:
undetectable		 1wsvB-4ig7A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ikn AP-3 COMPLEX SUBUNIT
MU-1

(Rattus
norvegicus) 		PF00928
(Adap_comp_sub) 		5 THR A 294
LEU A 351
ILE A 295
VAL A 274
ASN A 300
 THR  A 294 ( 0.8A)
LEU  A 351 ( 0.6A)
ILE  A 295 ( 0.6A)
VAL  A 274 ( 0.5A)
ASN  A 300 ( 0.6A)
 1.23A 1wsvB-4iknA:
undetectable		 1wsvB-4iknA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j38 OUTER SURFACE
PROTEIN E

(Borreliella
burgdorferi) 		PF02471
(OspE) 		5 THR A 101
LEU A 166
ILE A 142
PHE A  96
LEU A  63
 None
 1.19A 1wsvB-4j38A:
undetectable		 1wsvB-4j38A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhv LACCASE

(Coriolopsis
caperata) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 THR A 144
ILE A 187
VAL A 186
PHE A 245
LEU A 148
 None
 1.30A 1wsvB-4jhvA:
undetectable		 1wsvB-4jhvA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kyi VIPD

(Legionella
pneumophila) 		PF01734
(Patatin) 		5 THR A 180
LEU A 179
ILE A 176
VAL A 173
LEU A 163
 None
 1.34A 1wsvB-4kyiA:
undetectable		 1wsvB-4kyiA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l95 GAMMA-GLUTAMYL
HYDROLASE

(Danio rerio) 		no annotation 5 MET E 205
LEU E 124
ILE E 173
VAL E 202
LEU E 116
 None
 0.92A 1wsvB-4l95E:
undetectable		 1wsvB-4l95E:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mhp GLUTAMINYL CYCLASE,
PUTATIVE

(Ixodes
scapularis) 		PF04389
(Peptidase_M28) 		5 THR A 174
LEU A 175
VAL A 233
LEU A 155
TRP A  90
 None
 1.31A 1wsvB-4mhpA:
undetectable		 1wsvB-4mhpA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n9x PUTATIVE
MONOOXYGENASE

(Pectobacterium
atrosepticum) 		PF01494
(FAD_binding_3) 		5 THR A 156
LEU A 155
ILE A 147
VAL A 138
LEU A 130
 None
 1.29A 1wsvB-4n9xA:
undetectable		 1wsvB-4n9xA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nee AP-2 COMPLEX SUBUNIT
ALPHA-2

(Rattus
norvegicus) 		no annotation 5 LEU G 288
ILE G 287
VAL G 309
CYH G 283
LEU G 326
 None
 1.09A 1wsvB-4neeG:
undetectable		 1wsvB-4neeG:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qhb UNCHARACTERIZED
PROTEIN

(Bacteroides
vulgatus) 		PF09112
(N-glycanase_N)
PF09113
(N-glycanase_C) 		5 MET A 222
THR A  76
LEU A  77
ILE A  75
VAL A  38
 None
 1.34A 1wsvB-4qhbA:
undetectable		 1wsvB-4qhbA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x36 AUTOLYSIN

(Streptococcus
pneumoniae) 		PF01473
(CW_binding_1)
PF01510
(Amidase_2) 		5 THR A 121
LEU A 122
ILE A 130
VAL A  23
TYR A 105
 None
 1.07A 1wsvB-4x36A:
undetectable		 1wsvB-4x36A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zas CALS13

(Micromonospora
echinospora) 		PF01041
(DegT_DnrJ_EryC1) 		5 THR A  91
LEU A  90
ILE A 138
VAL A 170
MET A 122
 None
 1.07A 1wsvB-4zasA:
undetectable		 1wsvB-4zasA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0z CHOLINE
TRIMETHYLAMINE LYASE

(Klebsiella
pneumoniae) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		5 ILE A 730
VAL A 733
PHE A 745
CYH A 743
LEU A1062
 None
 1.29A 1wsvB-5a0zA:
undetectable		 1wsvB-5a0zA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5axh DEXTRANASE

(Thermoanaerobacter
pseudethanolicus) 		PF13199
(Glyco_hydro_66) 		5 ILE A  44
VAL A  47
ASN A 137
PHE A  74
TYR A 125
 None
None
GOL  A 708 (-4.7A)
None
None
 1.12A 1wsvB-5axhA:
undetectable		 1wsvB-5axhA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bu1 LPG1496

(Legionella
pneumophila) 		PF12252
(SidE) 		5 ILE A 547
VAL A 548
PHE A 517
TYR A 542
LEU A 377
 None
 1.32A 1wsvB-5bu1A:
undetectable		 1wsvB-5bu1A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqn FRBJ

(Streptomyces
rubellomurinus) 		PF02668
(TauD) 		5 MET A 278
LEU A  62
ILE A  38
VAL A  88
LEU A 107
 None
 1.28A 1wsvB-5eqnA:
undetectable		 1wsvB-5eqnA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fim YGAU

(Escherichia
coli) 		PF01476
(LysM)
PF04972
(BON) 		5 THR A 106
LEU A 107
ILE A 110
VAL A 114
LEU A 132
 None
 1.12A 1wsvB-5fimA:
undetectable		 1wsvB-5fimA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5z ABC TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF01547
(SBP_bac_1) 		5 LEU A 281
ILE A 278
VAL A 275
PHE A 312
LEU A 204
 None
 1.32A 1wsvB-5g5zA:
undetectable		 1wsvB-5g5zA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h42 UNCHARACTERIZED
PROTEIN

(Lachnoclostridium
phytofermentans) 		PF17167
(Glyco_hydro_36) 		5 THR A 515
LEU A 516
ILE A 536
VAL A 463
LEU A 480
 None
 1.34A 1wsvB-5h42A:
undetectable		 1wsvB-5h42A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hop LMO0182 PROTEIN

(Listeria
monocytogenes) 		no annotation 5 THR A 132
LEU A 131
ILE A 130
VAL A 159
CYH A 120
 None
 1.31A 1wsvB-5hopA:
undetectable		 1wsvB-5hopA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mew LACCASE 2

(Steccherinum
murashkinskyi) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 THR A 145
ILE A 191
VAL A 190
PHE A 249
LEU A 149
 None
 1.32A 1wsvB-5mewA:
undetectable		 1wsvB-5mewA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msy GLYCOSIDE HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF12904
(Collagen_bind_2)
PF13204
(DUF4038) 		5 LEU A  78
ILE A  89
VAL A  88
ASN A 179
PHE A 332
 None
 1.17A 1wsvB-5msyA:
undetectable		 1wsvB-5msyA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nbq OUTER SURFACE
PROTEIN E

(Borreliella
burgdorferi) 		no annotation 5 THR G 101
LEU G 166
ILE G 142
PHE G  96
LEU G  63
 None
 1.25A 1wsvB-5nbqG:
undetectable		 1wsvB-5nbqG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1) 		no annotation 5 THR A 786
LEU A 822
ILE A 787
CYH A 820
LEU A 846
 None
 1.23A 1wsvB-5nd1A:
undetectable		 1wsvB-5nd1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd5 TRANSKETOLASE

(Chlamydomonas
reinhardtii) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 LEU A 294
ILE A 295
VAL A 268
LEU A 206
TRP A 263
 None
 1.36A 1wsvB-5nd5A:
undetectable		 1wsvB-5nd5A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nsj PRE-GLYCOPROTEIN
POLYPROTEIN GP
COMPLEX

(Whitewater
Arroyo
mammarenavirus) 		no annotation 5 MET A 190
THR A 178
ILE A 177
VAL A 186
LEU A 210
 None
 1.34A 1wsvB-5nsjA:
undetectable		 1wsvB-5nsjA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ny0 L. REUTERIS SRRP
BINDING REGION

(Lactobacillus
reuteri) 		no annotation 5 THR A 474
LEU A 475
ILE A 441
VAL A 389
LEU A 467
 None
 1.32A 1wsvB-5ny0A:
undetectable		 1wsvB-5ny0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oex -

(-) 		no annotation 5 THR A 107
LEU A 122
VAL A  99
MET A 134
LEU A 191
 None
 1.28A 1wsvB-5oexA:
undetectable		 1wsvB-5oexA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5of3 DNA PRIMASE LARGE
SUBUNIT PRIL

(Sulfolobus
solfataricus) 		no annotation 5 THR B 236
ILE B 235
VAL B 260
ASN B 256
LEU B 226
 None
 1.23A 1wsvB-5of3B:
undetectable		 1wsvB-5of3B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Eremothecium
gossypii) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 LEU A 224
ILE A 213
VAL A 221
ASN A 122
LEU A 196
 GDP  A 603 ( 4.3A)
None
None
None
GDP  A 603 ( 4.6A)
 1.23A 1wsvB-5tc3A:
undetectable		 1wsvB-5tc3A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uju NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans) 		PF00171
(Aldedh) 		5 LEU A 167
ILE A 194
VAL A 195
ASN A 225
TRP A 164
 None
 1.27A 1wsvB-5ujuA:
undetectable		 1wsvB-5ujuA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xzd ENOYL-COA HYDRATASE

(Roseovarius
nubinhibens) 		no annotation 5 THR A  18
LEU A  19
ILE A   6
ASN A  29
LEU A 113
 None
 1.31A 1wsvB-5xzdA:
undetectable		 1wsvB-5xzdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z5d BETA-XYLOSIDASE

(Geobacillus
thermoleovorans) 		no annotation 5 THR A 377
LEU A 378
ILE A 439
VAL A 454
ASN A 457
 None
 0.91A 1wsvB-5z5dA:
undetectable		 1wsvB-5z5dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zh5 LYSINE--TRNA LIGASE

(Plasmodium
falciparum) 		no annotation 5 MET A 494
THR A 561
LEU A 564
ILE A 560
VAL A 501
 None
None
None
None
9CX  A 602 (-4.8A)
 1.35A 1wsvB-5zh5A:
undetectable		 1wsvB-5zh5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6chj DIACYLGLYCEROL
O-ACYLTRANSFERASE

(Marinobacter
hydrocarbonoclasticus) 		no annotation 5 THR A 413
ILE A 378
VAL A 293
CYH A 270
LEU A 231
 None
 1.31A 1wsvB-6chjA:
undetectable		 1wsvB-6chjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en4 SPLICING FACTOR 3B
SUBUNIT 3

(Homo sapiens) 		no annotation 5 THR A 761
LEU A 762
ILE A 757
PHE A 478
LEU A 485
 None
 1.27A 1wsvB-6en4A:
undetectable		 1wsvB-6en4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB

(Yersinia
pseudotuberculosis) 		no annotation 5 THR A 200
LEU A 199
ILE A 246
VAL A 270
PHE A 228
 THR  A 200 ( 0.8A)
LEU  A 199 ( 0.5A)
ILE  A 246 ( 0.7A)
VAL  A 270 ( 0.6A)
PHE  A 228 ( 1.3A)
 1.23A 1wsvB-6gefA:
undetectable		 1wsvB-6gefA:
undetectable