SIMILAR PATTERNS OF AMINO ACIDS FOR 1WSV_A_THHA3001_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dkg MOLECULAR CHAPERONE
DNAK

(Escherichia
coli) 		PF00012
(HSP70) 		5 THR D 141
LEU D   9
ILE D 140
VAL D 165
PHE D 146
 None
 1.36A 1wsvA-1dkgD:
0.0		 1wsvA-1dkgD:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0v PROTEINASE A

(Saccharomyces
cerevisiae) 		PF00026
(Asp) 		5 THR A 268
LEU A 258
ILE A 269
PHE A 262
LEU A 223
 None
 1.16A 1wsvA-1g0vA:
0.4		 1wsvA-1g0vA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gll GLYCEROL KINASE

(Escherichia
coli) 		no annotation 5 LEU Y 169
ILE Y 170
VAL Y 180
ASN Y 185
MET Y 173
 None
 1.31A 1wsvA-1gllY:
0.0		 1wsvA-1gllY:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyc LACCASE 2

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 THR A 144
ILE A 188
VAL A 187
PHE A 246
LEU A 148
 None
 1.26A 1wsvA-1gycA:
0.0		 1wsvA-1gycA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j08 GLUTAREDOXIN-LIKE
PROTEIN

(Pyrococcus
horikoshii) 		PF00085
(Thioredoxin)
PF13192
(Thioredoxin_3) 		5 LEU A  26
ILE A  84
VAL A  93
PHE A  17
LEU A  44
 None
 1.26A 1wsvA-1j08A:
undetectable		 1wsvA-1j08A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1khw RNA-DIRECTED RNA
POLYMERASE

(Rabbit
hemorrhagic
disease virus) 		PF00680
(RdRP_1) 		5 MET A 227
THR A 240
LEU A 239
ILE A 236
VAL A 232
 None
 1.21A 1wsvA-1khwA:
0.0		 1wsvA-1khwA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kya LACCASE

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 THR A 144
ILE A 188
VAL A 187
PHE A 246
LEU A 148
 None
 1.25A 1wsvA-1kyaA:
undetectable		 1wsvA-1kyaA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q90 CYTOCHROME B6-F
COMPLEX IRON-SULFUR
SUBUNIT

(Chlamydomonas
reinhardtii) 		PF00355
(Rieske) 		5 THR C 199
VAL C 166
PHE C 197
LEU C 130
TRP C 205
 None
 1.36A 1wsvA-1q90C:
undetectable		 1wsvA-1q90C:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tkc TRANSKETOLASE

(Saccharomyces
cerevisiae) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 LEU A 243
ILE A 244
VAL A 217
LEU A 155
TRP A 212
 None
 1.31A 1wsvA-1tkcA:
0.0		 1wsvA-1tkcA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v3t LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE/PROSTAGLANDIN
15-KETO REDUCTASE

(Cavia porcellus) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		5 LEU A 164
ILE A 296
VAL A 291
TYR A 130
LEU A 134
 None
 1.13A 1wsvA-1v3tA:
undetectable		 1wsvA-1v3tA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrb PUTATIVE ASPARAGINYL
HYDROXYLASE

(Bacillus
subtilis) 		PF08007
(Cupin_4) 		5 ILE A  13
VAL A  16
MET A 215
LEU A 121
TRP A 113
 None
 1.13A 1wsvA-1vrbA:
1.0		 1wsvA-1vrbA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrb PUTATIVE ASPARAGINYL
HYDROXYLASE

(Bacillus
subtilis) 		PF08007
(Cupin_4) 		5 LEU A   9
ILE A  13
VAL A  16
LEU A 121
TRP A 113
 None
 1.20A 1wsvA-1vrbA:
1.0		 1wsvA-1vrbA:
22.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wop AMINOMETHYLTRANSFERA
SE

(Thermotoga
maritima) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		6 MET A  51
VAL A 110
ASN A 112
TYR A 188
ARG A 227
TRP A 256
 FFO  A2887 (-4.6A)
FFO  A2887 (-4.0A)
FFO  A2887 (-3.3A)
FFO  A2887 (-3.5A)
FFO  A2887 (-3.6A)
None
 0.53A 1wsvA-1wopA:
50.1		 1wsvA-1wopA:
34.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wsv AMINOMETHYLTRANSFERA
SE

(Homo sapiens) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		12 MET A  56
THR A  87
LEU A  88
ILE A 103
VAL A 115
ASN A 117
PHE A 176
MET A 177
TYR A 197
ARG A 233
LEU A 242
TRP A 262
 MET  A  56 (-0.0A)
THR  A  87 ( 0.8A)
LEU  A  88 (-0.6A)
ILE  A 103 (-0.7A)
VAL  A 115 (-0.6A)
ASN  A 117 (-0.6A)
PHE  A 176 (-1.3A)
MET  A 177 (-0.0A)
TYR  A 197 (-1.3A)
ARG  A 233 (-0.6A)
LEU  A 242 (-0.6A)
TRP  A 262 ( 0.5A)
 0.02A 1wsvA-1wsvA:
66.6		 1wsvA-1wsvA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xau B- AND T-LYMPHOCYTE
ATTENUATOR

(Mus musculus) 		PF13895
(Ig_2) 		5 THR A 110
ILE A 111
VAL A 113
LEU A  59
TRP A  56
 None
 1.24A 1wsvA-1xauA:
undetectable		 1wsvA-1xauA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xcr HYPOTHETICAL PROTEIN
PTD012

(Homo sapiens) 		PF08925
(DUF1907) 		5 ILE A 171
VAL A  35
PHE A 253
MET A 203
LEU A  24
 None
 1.28A 1wsvA-1xcrA:
undetectable		 1wsvA-1xcrA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c45 ASPARTATE
1-DECARBOXYLASE
PRECURSOR

(Mycobacterium
tuberculosis) 		PF02261
(Asp_decarbox) 		5 THR A  45
LEU A  55
ILE A  46
VAL A  85
ASN A  51
 None
 1.22A 1wsvA-2c45A:
undetectable		 1wsvA-2c45A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ej5 ENOYL-COA HYDRATASE
SUBUNIT II

(Geobacillus
kaustophilus) 		PF00378
(ECH_1) 		5 THR A  19
LEU A  18
VAL A  15
PHE A  62
LEU A  92
 None
 1.28A 1wsvA-2ej5A:
undetectable		 1wsvA-2ej5A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz7 GLUTAMINYL-TRNA
SYNTHETASE

(Deinococcus
radiodurans) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C) 		5 THR A 495
LEU A 496
ILE A 476
VAL A 468
LEU A 440
 None
 0.76A 1wsvA-2hz7A:
undetectable		 1wsvA-2hz7A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzh LACCASE

(Trametes
ochracea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 THR A 144
ILE A 188
VAL A 187
PHE A 246
LEU A 148
 None
 1.27A 1wsvA-2hzhA:
undetectable		 1wsvA-2hzhA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inv INSULIN
FRUCTOTRANSFERASE

(Bacillus sp.
snu-7) 		no annotation 5 THR A 216
ILE A 215
ASN A 210
PHE A 183
MET A 218
 None
 1.32A 1wsvA-2invA:
undetectable		 1wsvA-2invA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix5 ACYL-COENZYME A
OXIDASE 4,
PEROXISOMAL

(Arabidopsis
thaliana) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 MET A 300
LEU A 342
VAL A 337
ARG A  63
LEU A  54
 None
 1.36A 1wsvA-2ix5A:
undetectable		 1wsvA-2ix5A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j66 BTRK

(Bacillus
circulans) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 THR A 205
LEU A 208
ILE A 184
PHE A 261
TYR A 216
 None
 1.22A 1wsvA-2j66A:
undetectable		 1wsvA-2j66A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mbx PARVALBUMIN BETA

(Gadus morhua) 		PF13499
(EF-hand_7) 		5 LEU A  87
ILE A  98
PHE A  31
MET A 106
LEU A  78
 None
 1.14A 1wsvA-2mbxA:
undetectable		 1wsvA-2mbxA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjc DIADENOSINE
TETRAPHOSPHATASE,
PUTATIVE

(Trypanosoma
brucei) 		PF00149
(Metallophos) 		5 THR A  49
LEU A  50
ILE A  22
VAL A 235
LEU A  34
 None
 1.22A 1wsvA-2qjcA:
undetectable		 1wsvA-2qjcA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt6 LACCASE

(Lentinus
tigrinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 THR A 144
ILE A 188
VAL A 187
PHE A 246
LEU A 148
 None
 1.30A 1wsvA-2qt6A:
undetectable		 1wsvA-2qt6A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wjs LAMININ SUBUNIT
ALPHA-2

(Mus musculus) 		PF00054
(Laminin_G_1) 		5 THR A2422
LEU A2423
ILE A2432
VAL A2445
PHE A2362
 None
 1.25A 1wsvA-2wjsA:
undetectable		 1wsvA-2wjsA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3l ORN/LYS/ARG
DECARBOXYLASE FAMILY
PROTEIN

(Staphylococcus
aureus) 		PF01276
(OKR_DC_1)
PF03711
(OKR_DC_1_C) 		5 THR A 153
ILE A 180
VAL A 205
PHE A 162
LEU A 171
 PLP  A1211 ( 4.2A)
None
None
None
None
 1.06A 1wsvA-2x3lA:
0.2		 1wsvA-2x3lA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyb LACCASE

(Trametes
cinnabarina) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 THR A 144
ILE A 188
VAL A 187
PHE A 246
LEU A 148
 None
 1.27A 1wsvA-2xybA:
undetectable		 1wsvA-2xybA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3a PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT BETA ISOFORM

(Mus musculus) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B) 		5 THR A 330
LEU A 331
ILE A 487
VAL A 451
PHE A 381
 None
 1.18A 1wsvA-2y3aA:
undetectable		 1wsvA-2y3aA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia pestis) 		PF00496
(SBP_bac_5) 		5 THR A 143
LEU A 144
ILE A  76
VAL A  88
LEU A 159
 None
 1.29A 1wsvA-2z23A:
undetectable		 1wsvA-2z23A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zu6 EUKARYOTIC
INITIATION FACTOR
4A-I

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 LEU A 263
ILE A 345
VAL A 344
MET A 375
LEU A 288
 None
 1.20A 1wsvA-2zu6A:
undetectable		 1wsvA-2zu6A:
22.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3a8k AMINOMETHYLTRANSFERA
SE

(Escherichia
coli) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		7 MET A  51
ILE A  99
VAL A 111
ASN A 113
TYR A 188
ARG A 223
TRP A 252
 None
 0.62A 1wsvA-3a8kA:
46.5		 1wsvA-3a8kA:
33.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3azc CYTOCHROME B6-F
COMPLEX IRON-SULFUR
SUBUNIT

(Thermosynechococcus
elongatus) 		PF00355
(Rieske) 		5 THR A 173
VAL A 140
PHE A 171
LEU A 104
TRP A 179
 None
 1.11A 1wsvA-3azcA:
undetectable		 1wsvA-3azcA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8y ENDO-PECTATE LYASE

(Dickeya
chrysanthemi) 		PF03211
(Pectate_lyase) 		5 THR A 292
LEU A 266
ILE A 293
VAL A 308
LEU A 226
 None
 1.29A 1wsvA-3b8yA:
undetectable		 1wsvA-3b8yA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b90 ENDO-PECTATE LYASE

(Dickeya
chrysanthemi) 		PF03211
(Pectate_lyase) 		5 THR A 292
LEU A 266
ILE A 293
VAL A 308
LEU A 226
 None
 1.30A 1wsvA-3b90A:
undetectable		 1wsvA-3b90A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bif PROTEIN
(6-PHOSPHOFRUCTO-2-K
INASE/
FRUCTOSE-2,6-BISPHOS
PHATASE)

(Rattus
norvegicus) 		PF00300
(His_Phos_1)
PF01591
(6PF2K) 		5 THR A  39
LEU A  40
ILE A  41
VAL A 154
ASN A 131
 None
 1.24A 1wsvA-3bifA:
undetectable		 1wsvA-3bifA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bl2 V-BCL-2

(Murid
gammaherpesvirus
4) 		PF15286
(Bcl-2_3) 		6 VAL A  21
PHE A  75
MET A 119
TYR A  97
ARG A  49
LEU A  64
 None
 1.25A 1wsvA-3bl2A:
undetectable		 1wsvA-3bl2A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmg PUTATIVE
BETA-GALACTOSIDASE

(Bacteroides
fragilis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		5 ILE A 355
VAL A 322
ASN A 563
MET A 370
ARG A 590
 None
 1.32A 1wsvA-3cmgA:
undetectable		 1wsvA-3cmgA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d2l SAM-DEPENDENT
METHYLTRANSFERASE

(Exiguobacterium
sibiricum) 		PF13649
(Methyltransf_25) 		5 THR A 100
ILE A 101
ASN A 107
TYR A 205
TRP A  25
 None
 1.18A 1wsvA-3d2lA:
undetectable		 1wsvA-3d2lA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9k KYNURENINASE

(Homo sapiens) 		PF00266
(Aminotran_5) 		5 THR A 455
LEU A 458
ILE A 457
ASN A 411
PHE A 450
 None
 1.28A 1wsvA-3e9kA:
undetectable		 1wsvA-3e9kA:
22.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gir AMINOMETHYLTRANSFERA
SE

(Bartonella
henselae) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		10 MET A  63
ILE A 110
VAL A 122
ASN A 124
PHE A 177
MET A 178
TYR A 194
ARG A 230
LEU A 239
TRP A 259
 None
 0.55A 1wsvA-3girA:
50.0		 1wsvA-3girA:
40.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5g MYOSIN HEAVY CHAIN
ISOFORM A
MYOSIN CATALYTIC
LIGHT CHAIN LC-1,
MANTLE MUSCLE

(Doryteuthis
pealeii;
Todarodes
pacificus) 		PF00063
(Myosin_head)
PF00612
(IQ)
PF02736
(Myosin_N)
PF13405
(EF-hand_6) 		5 THR A 811
LEU A 810
ILE A 813
VAL A 817
TRP C  21
 None
 1.24A 1wsvA-3i5gA:
undetectable		 1wsvA-3i5gA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihm STYRENE
MONOOXYGENASE A

(Pseudomonas
putida) 		no annotation 5 THR A 185
ILE A 196
VAL A 211
ASN A 214
LEU A 358
 None
 1.25A 1wsvA-3ihmA:
undetectable		 1wsvA-3ihmA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iyj MAJOR CAPSID PROTEIN
L1

(Deltapapillomavirus
4) 		no annotation 5 THR F 158
VAL F  68
ASN F 445
PHE F 243
LEU F  73
 None
 1.30A 1wsvA-3iyjF:
undetectable		 1wsvA-3iyjF:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kkd TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		PF00440
(TetR_N) 		5 THR A 200
LEU A 199
ILE A 203
VAL A 138
LEU A 231
 PGE  A 238 ( 4.5A)
None
PGE  A 238 ( 4.6A)
None
None
 1.32A 1wsvA-3kkdA:
undetectable		 1wsvA-3kkdA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ln3 DIHYDRODIOL
DEHYDROGENASE

(Mus musculus) 		PF00248
(Aldo_ket_red) 		5 THR A  83
ILE A 115
VAL A 165
ASN A 167
LEU A 268
 None
None
None
NAD  A 327 (-3.3A)
NAD  A 327 ( 4.4A)
 1.31A 1wsvA-3ln3A:
undetectable		 1wsvA-3ln3A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxl LACCASE

(Trametes
hirsuta) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 THR A 144
ILE A 188
VAL A 187
PHE A 246
LEU A 148
 None
 1.30A 1wsvA-3pxlA:
undetectable		 1wsvA-3pxlA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q0g ENOYL-COA HYDRATASE
ECHA8

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1) 		5 THR A  18
LEU A  19
ILE A   6
ASN A  29
LEU A 112
 None
 1.27A 1wsvA-3q0gA:
undetectable		 1wsvA-3q0gA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rjo ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1

(Homo sapiens) 		PF11838
(ERAP1_C) 		5 MET A 604
THR A 534
LEU A 532
ILE A 533
VAL A 602
 None
 1.29A 1wsvA-3rjoA:
undetectable		 1wsvA-3rjoA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwx HYPOTHETICAL
BACTERIAL OUTER
MEMBRANE PROTEIN

(Bacteroides
fragilis) 		PF13944
(Calycin_like) 		5 THR A 265
ILE A 275
VAL A 169
PHE A 216
LEU A 165
 None
 1.14A 1wsvA-3rwxA:
undetectable		 1wsvA-3rwxA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5k FALCILYSIN

(Plasmodium
falciparum) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		5 LEU A 252
ILE A 445
VAL A 444
ASN A 857
LEU A 584
 None
 1.35A 1wsvA-3s5kA:
undetectable		 1wsvA-3s5kA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6w LACCASE

(Steccherinum
ochraceum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 THR A 145
ILE A 191
VAL A 190
PHE A 249
LEU A 149
 None
 1.26A 1wsvA-3t6wA:
undetectable		 1wsvA-3t6wA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vn9 DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 155
ILE A 158
PHE A 327
TYR A 140
LEU A 253
 None
 1.08A 1wsvA-3vn9A:
undetectable		 1wsvA-3vn9A:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbg FATTY ACID-BINDING
PROTEIN, HEART

(Homo sapiens) 		PF00061
(Lipocalin) 		5 THR A  50
LEU A  51
VAL A   1
PHE A  70
LEU A 104
 None
 0.91A 1wsvA-3wbgA:
undetectable		 1wsvA-3wbgA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1b LACCASE

(Lentinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 THR A 165
ILE A 209
VAL A 208
PHE A 267
LEU A 169
 None
 1.27A 1wsvA-3x1bA:
undetectable		 1wsvA-3x1bA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aq9 ACETYLCHOLINE
RECEPTOR GAMMA
SUBUNIT

(Torpedo
marmorata) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		5 THR E  50
LEU E  49
VAL E  95
ASN E  93
LEU E 212
 None
 1.33A 1wsvA-4aq9E:
undetectable		 1wsvA-4aq9E:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus musculus) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd) 		5 THR A 330
LEU A 331
ILE A 487
VAL A 451
PHE A 381
 None
 1.13A 1wsvA-4bfrA:
undetectable		 1wsvA-4bfrA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d72 GLYCOSIDE HYDROLASE

(Streptococcus
pneumoniae) 		PF08306
(Glyco_hydro_98M)
PF08307
(Glyco_hydro_98C) 		5 THR A 520
LEU A 519
ILE A 518
VAL A 475
ASN A 550
 None
 1.16A 1wsvA-4d72A:
undetectable		 1wsvA-4d72A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e2z TCAB9

(Micromonospora
chalcea) 		PF08421
(Methyltransf_13)
PF08484
(Methyltransf_14)
PF13489
(Methyltransf_23) 		5 MET A  71
THR A  63
LEU A  62
VAL A  66
TYR A 222
 None
 1.31A 1wsvA-4e2zA:
undetectable		 1wsvA-4e2zA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6n UBIQUITIN
CARBOXYL-HYDROLASE

(Trichinella
spiralis) 		PF01088
(Peptidase_C12) 		5 THR A 128
LEU A 127
ILE A 133
VAL A 136
LEU A  95
 None
 1.32A 1wsvA-4i6nA:
undetectable		 1wsvA-4i6nA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ikn AP-3 COMPLEX SUBUNIT
MU-1

(Rattus
norvegicus) 		PF00928
(Adap_comp_sub) 		5 THR A 294
LEU A 351
ILE A 295
VAL A 274
ASN A 300
 THR  A 294 ( 0.8A)
LEU  A 351 ( 0.6A)
ILE  A 295 ( 0.6A)
VAL  A 274 ( 0.5A)
ASN  A 300 ( 0.6A)
 1.18A 1wsvA-4iknA:
undetectable		 1wsvA-4iknA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j38 OUTER SURFACE
PROTEIN E

(Borreliella
burgdorferi) 		PF02471
(OspE) 		5 THR A 101
LEU A 166
ILE A 142
PHE A  96
LEU A  63
 None
 1.21A 1wsvA-4j38A:
0.8		 1wsvA-4j38A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhv LACCASE

(Coriolopsis
caperata) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 THR A 144
ILE A 187
VAL A 186
PHE A 245
LEU A 148
 None
 1.29A 1wsvA-4jhvA:
undetectable		 1wsvA-4jhvA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jw1 EFFECTOR PROTEIN B

(Legionella
pneumophila) 		no annotation 5 THR A 472
LEU A 471
VAL A 435
PHE A 510
LEU A 381
 None
 1.14A 1wsvA-4jw1A:
undetectable		 1wsvA-4jw1A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kyi VIPD

(Legionella
pneumophila) 		PF01734
(Patatin) 		5 THR A 180
LEU A 179
ILE A 176
VAL A 173
LEU A 163
 None
 1.35A 1wsvA-4kyiA:
undetectable		 1wsvA-4kyiA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l95 GAMMA-GLUTAMYL
HYDROLASE

(Danio rerio) 		no annotation 5 MET E 205
LEU E 124
ILE E 173
VAL E 202
LEU E 116
 None
 0.92A 1wsvA-4l95E:
undetectable		 1wsvA-4l95E:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mhp GLUTAMINYL CYCLASE,
PUTATIVE

(Ixodes
scapularis) 		PF04389
(Peptidase_M28) 		5 THR A 174
LEU A 175
VAL A 233
LEU A 155
TRP A  90
 None
 1.35A 1wsvA-4mhpA:
undetectable		 1wsvA-4mhpA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n9x PUTATIVE
MONOOXYGENASE

(Pectobacterium
atrosepticum) 		PF01494
(FAD_binding_3) 		5 THR A 156
LEU A 155
ILE A 147
VAL A 138
LEU A 130
 None
 1.27A 1wsvA-4n9xA:
undetectable		 1wsvA-4n9xA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqj PKS

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 THR A 381
LEU A 385
ILE A 382
VAL A  22
TRP A 419
 None
 1.35A 1wsvA-4oqjA:
undetectable		 1wsvA-4oqjA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qhb UNCHARACTERIZED
PROTEIN

(Bacteroides
vulgatus) 		PF09112
(N-glycanase_N)
PF09113
(N-glycanase_C) 		5 MET A 222
THR A  76
LEU A  77
ILE A  75
VAL A  38
 None
 1.30A 1wsvA-4qhbA:
undetectable		 1wsvA-4qhbA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x36 AUTOLYSIN

(Streptococcus
pneumoniae) 		PF01473
(CW_binding_1)
PF01510
(Amidase_2) 		5 THR A 121
LEU A 122
ILE A 130
VAL A  23
TYR A 105
 None
 1.08A 1wsvA-4x36A:
undetectable		 1wsvA-4x36A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9n L-ALPHA-GLYCEROPHOSP
HATE OXIDASE

(Mycoplasma
pneumoniae) 		PF01266
(DAO) 		5 THR A  90
LEU A  91
ILE A  92
VAL A 252
LEU A 123
 None
 1.36A 1wsvA-4x9nA:
undetectable		 1wsvA-4x9nA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7r COENZYME PQQ
SYNTHESIS PROTEIN B

(Methylobacterium
extorquens) 		PF12706
(Lactamase_B_2) 		5 THR A 111
VAL A 156
PHE A 143
TYR A 192
LEU A  54
 None
 1.31A 1wsvA-4z7rA:
undetectable		 1wsvA-4z7rA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zas CALS13

(Micromonospora
echinospora) 		PF01041
(DegT_DnrJ_EryC1) 		5 THR A  91
LEU A  90
ILE A 138
VAL A 170
MET A 122
 None
 1.10A 1wsvA-4zasA:
undetectable		 1wsvA-4zasA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5axh DEXTRANASE

(Thermoanaerobacter
pseudethanolicus) 		PF13199
(Glyco_hydro_66) 		5 ILE A  44
VAL A  47
ASN A 137
PHE A  74
TYR A 125
 None
None
GOL  A 708 (-4.7A)
None
None
 1.15A 1wsvA-5axhA:
2.8		 1wsvA-5axhA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bq9 UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		PF12252
(SidE) 		5 ILE A 547
VAL A 548
PHE A 517
TYR A 542
LEU A 377
 None
 1.24A 1wsvA-5bq9A:
undetectable		 1wsvA-5bq9A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bu1 LPG1496

(Legionella
pneumophila) 		PF12252
(SidE) 		5 ILE A 547
VAL A 548
PHE A 517
TYR A 542
LEU A 377
 None
 1.30A 1wsvA-5bu1A:
undetectable		 1wsvA-5bu1A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bu2 LPG1496

(Legionella
pneumophila) 		PF12252
(SidE) 		5 ILE A 547
VAL A 548
PHE A 517
TYR A 542
LEU A 377
 None
 1.26A 1wsvA-5bu2A:
undetectable		 1wsvA-5bu2A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ctv AUTOLYSIN

(Streptococcus
pneumoniae) 		PF01510
(Amidase_2) 		5 THR A 121
LEU A 122
ILE A 130
VAL A  23
TYR A 105
 None
 1.08A 1wsvA-5ctvA:
undetectable		 1wsvA-5ctvA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqn FRBJ

(Streptomyces
rubellomurinus) 		PF02668
(TauD) 		5 MET A 278
LEU A  62
ILE A  38
VAL A  88
LEU A 107
 None
 1.34A 1wsvA-5eqnA:
undetectable		 1wsvA-5eqnA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1)
PF08996
(zf-DNA_Pol) 		5 LEU C1212
ILE C1216
VAL C1220
PHE C1133
ARG C1115
 None
 1.18A 1wsvA-5exrC:
undetectable		 1wsvA-5exrC:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f6j ENVELOPE
GLYCOPROTEIN GP120
OF HIV-1 CLADE C

(Human
immunodeficiency
virus 1) 		no annotation 5 MET G 100
THR G 244
LEU G 226
ILE G 225
ARG G 480
 None
 1.34A 1wsvA-5f6jG:
undetectable		 1wsvA-5f6jG:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fim YGAU

(Escherichia
coli) 		PF01476
(LysM)
PF04972
(BON) 		5 THR A 106
LEU A 107
ILE A 110
VAL A 114
LEU A 132
 None
 1.07A 1wsvA-5fimA:
undetectable		 1wsvA-5fimA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h42 UNCHARACTERIZED
PROTEIN

(Lachnoclostridium
phytofermentans) 		PF17167
(Glyco_hydro_36) 		5 THR A 515
LEU A 516
ILE A 536
VAL A 463
LEU A 480
 None
 1.34A 1wsvA-5h42A:
undetectable		 1wsvA-5h42A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5htk 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 2

(Homo sapiens) 		PF00300
(His_Phos_1)
PF01591
(6PF2K) 		5 THR A 424
LEU A 423
ILE A 252
VAL A 386
LEU A 399
 None
 1.31A 1wsvA-5htkA:
undetectable		 1wsvA-5htkA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i1t STAGE II SPORULATION
PROTEIN D

(Clostridioides
difficile) 		PF08486
(SpoIID) 		5 THR A 285
LEU A 284
ASN A 281
PHE A 300
LEU A 245
 None
 1.03A 1wsvA-5i1tA:
undetectable		 1wsvA-5i1tA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jmu PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE

([Eubacterium]
rectale) 		PF01522
(Polysacc_deac_1) 		5 THR A 479
ILE A 292
VAL A 445
ASN A 421
LEU A 483
 None
 1.35A 1wsvA-5jmuA:
undetectable		 1wsvA-5jmuA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mew LACCASE 2

(Steccherinum
murashkinskyi) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 THR A 145
ILE A 191
VAL A 190
PHE A 249
LEU A 149
 None
 1.31A 1wsvA-5mewA:
undetectable		 1wsvA-5mewA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msy GLYCOSIDE HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF12904
(Collagen_bind_2)
PF13204
(DUF4038) 		5 LEU A  78
ILE A  89
VAL A  88
ASN A 179
PHE A 332
 None
 1.17A 1wsvA-5msyA:
undetectable		 1wsvA-5msyA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nbq OUTER SURFACE
PROTEIN E

(Borreliella
burgdorferi) 		no annotation 5 THR G 101
LEU G 166
ILE G 142
PHE G  96
LEU G  63
 None
 1.27A 1wsvA-5nbqG:
undetectable		 1wsvA-5nbqG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nsj PRE-GLYCOPROTEIN
POLYPROTEIN GP
COMPLEX

(Whitewater
Arroyo
mammarenavirus) 		no annotation 5 MET A 190
THR A 178
ILE A 177
VAL A 186
LEU A 210
 None
 1.36A 1wsvA-5nsjA:
undetectable		 1wsvA-5nsjA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ny0 L. REUTERIS SRRP
BINDING REGION

(Lactobacillus
reuteri) 		no annotation 5 THR A 474
LEU A 475
ILE A 441
VAL A 389
LEU A 467
 None
 1.32A 1wsvA-5ny0A:
undetectable		 1wsvA-5ny0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oar BETA-HEXOSAMINIDASE

(Aspergillus
oryzae) 		no annotation 5 THR B 129
LEU B 130
ILE B 141
VAL B 111
LEU B 159
 None
 1.36A 1wsvA-5oarB:
undetectable		 1wsvA-5oarB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Eremothecium
gossypii) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 LEU A 224
ILE A 213
VAL A 221
ASN A 122
LEU A 196
 GDP  A 603 ( 4.3A)
None
None
None
GDP  A 603 ( 4.6A)
 1.22A 1wsvA-5tc3A:
undetectable		 1wsvA-5tc3A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xzd ENOYL-COA HYDRATASE

(Roseovarius
nubinhibens) 		no annotation 5 THR A  18
LEU A  19
ILE A   6
ASN A  29
LEU A 113
 None
 1.29A 1wsvA-5xzdA:
undetectable		 1wsvA-5xzdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z5d BETA-XYLOSIDASE

(Geobacillus
thermoleovorans) 		no annotation 5 THR A 377
LEU A 378
ILE A 439
VAL A 454
ASN A 457
 None
 0.89A 1wsvA-5z5dA:
undetectable		 1wsvA-5z5dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zh5 LYSINE--TRNA LIGASE

(Plasmodium
falciparum) 		no annotation 5 MET A 494
THR A 561
LEU A 564
ILE A 560
VAL A 501
 None
None
None
None
9CX  A 602 (-4.8A)
 1.35A 1wsvA-5zh5A:
undetectable		 1wsvA-5zh5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en4 SPLICING FACTOR 3B
SUBUNIT 3

(Homo sapiens) 		no annotation 5 THR A 761
LEU A 762
ILE A 757
PHE A 478
LEU A 485
 None
 1.27A 1wsvA-6en4A:
undetectable		 1wsvA-6en4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB

(Yersinia
pseudotuberculosis) 		no annotation 5 THR A 200
LEU A 199
ILE A 246
VAL A 270
PHE A 228
 THR  A 200 ( 0.8A)
LEU  A 199 ( 0.5A)
ILE  A 246 ( 0.7A)
VAL  A 270 ( 0.6A)
PHE  A 228 ( 1.3A)
 1.22A 1wsvA-6gefA:
undetectable		 1wsvA-6gefA:
undetectable