SIMILAR PATTERNS OF AMINO ACIDS FOR 1WRQ_A_HISA2001

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)

(Pyrococcus
furiosus) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		4 ARG A  35
ILE A 433
GLY A 434
ALA A 435
 None
 0.80A 1wrqA-1b25A:
0.0		 1wrqA-1b25A:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bjn PHOSPHOSERINE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00266
(Aminotran_5) 		4 ILE A   4
GLY A 321
ALA A 320
HIS A 323
 None
 0.98A 1wrqA-1bjnA:
0.0		 1wrqA-1bjnA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Thermoanaerobacter
brockii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ILE A  86
GLY A 109
ALA A 108
HIS A 100
 None
 0.61A 1wrqA-1bxzA:
0.0		 1wrqA-1bxzA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cb8 PROTEIN
(CHONDROITINASE AC)

(Pedobacter
heparinus) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		4 ARG A 325
ILE A 336
GLY A 333
ALA A 331
 None
 0.87A 1wrqA-1cb8A:
0.0		 1wrqA-1cb8A:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ee2 ALCOHOL
DEHYDROGENASE

(Equus caballus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ARG A  84
ILE A  76
GLY A  77
ALA A  33
 None
 0.92A 1wrqA-1ee2A:
0.0		 1wrqA-1ee2A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ist CYCLOPHILIN A

(Saccharomyces
cerevisiae) 		PF00160
(Pro_isomerase) 		4 ARG A  53
ILE A  55
GLY A 148
ALA A 149
 None
 0.92A 1wrqA-1istA:
0.0		 1wrqA-1istA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k2w SORBITOL
DEHYDROGENASE

(Rhodobacter
sphaeroides) 		PF13561
(adh_short_C2) 		4 ARG A 143
ILE A 160
GLY A 142
ALA A 141
 None
 0.87A 1wrqA-1k2wA:
0.0		 1wrqA-1k2wA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7g GDP-D-MANNOSE-4,6-DE
HYDRATASE

(Arabidopsis
thaliana) 		PF16363
(GDP_Man_Dehyd) 		4 ILE A 211
GLY A 161
ALA A 160
HIS A 193
 None
None
NDP  A 701 (-3.5A)
None
 0.87A 1wrqA-1n7gA:
0.0		 1wrqA-1n7gA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ouu HEMOGLOBIN I

(Oncorhynchus
mykiss) 		PF00042
(Globin) 		4 ILE A  63
GLY A  60
ALA A  26
HIS A  59
 CMO  A 144 (-4.7A)
None
None
CMO  A 144 ( 3.5A)
 0.97A 1wrqA-1ouuA:
1.1		 1wrqA-1ouuA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qyc PHENYLCOUMARAN
BENZYLIC ETHER
REDUCTASE PT1

(Pinus taeda) 		PF05368
(NmrA) 		4 ILE A  16
GLY A  17
ALA A  12
HIS A  19
 None
 1.00A 1wrqA-1qycA:
undetectable		 1wrqA-1qycA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1spg HEMOGLOBIN

(Leiostomus
xanthurus) 		PF00042
(Globin) 		4 ILE A  64
GLY A  61
ALA A  26
HIS A  60
 CMO  A 145 ( 4.0A)
None
None
CMO  A 145 ( 3.9A)
 0.97A 1wrqA-1spgA:
1.2		 1wrqA-1spgA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uz5 402AA LONG
HYPOTHETICAL
MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN

(Pyrococcus
horikoshii) 		PF00994
(MoCF_biosynth)
PF03453
(MoeA_N)
PF03454
(MoeA_C) 		4 ARG A 158
ARG A 325
ILE A  37
ALA A 322
 None
SO4  A1404 (-3.2A)
None
None
 0.76A 1wrqA-1uz5A:
undetectable		 1wrqA-1uz5A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wiw GLUCOSE-6-PHOSPHATE
ISOMERASE LIKE
PROTEIN

(Thermus
thermophilus) 		PF10432
(bact-PGI_C) 		4 ARG A  90
GLY A  63
ALA A  89
HIS A  39
 None
 0.98A 1wrqA-1wiwA:
undetectable		 1wrqA-1wiwA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xc3 PUTATIVE
FRUCTOKINASE

(Bacillus
subtilis) 		PF00480
(ROK) 		4 ARG A  26
ILE A 277
GLY A 276
ALA A 107
 None
 0.87A 1wrqA-1xc3A:
undetectable		 1wrqA-1xc3A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c9a RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE MU

(Homo sapiens) 		PF00047
(ig)
PF00629
(MAM) 		4 ARG A 239
ILE A 209
GLY A 210
HIS A 187
 None
 0.87A 1wrqA-2c9aA:
undetectable		 1wrqA-2c9aA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fvh UREASE GAMMA SUBUNIT

(Mycobacterium
tuberculosis) 		PF00547
(Urease_gamma) 		4 ARG A  51
GLY A  46
ALA A  47
HIS A  42
 None
 0.92A 1wrqA-2fvhA:
undetectable		 1wrqA-2fvhA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuk SEED LIPOXYGENASE

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 ARG A 847
ILE A 643
GLY A 640
ALA A 637
 None
 0.83A 1wrqA-2iukA:
undetectable		 1wrqA-2iukA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lts PROTEIN RDE-4

(Caenorhabditis
elegans) 		PF00035
(dsrm) 		4 ARG A 211
ILE A 213
GLY A 212
ALA A 224
 None
 1.00A 1wrqA-2ltsA:
undetectable		 1wrqA-2ltsA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2py6 METHYLTRANSFERASE
FKBM

(Methylobacillus
flagellatus) 		PF05050
(Methyltransf_21) 		4 ARG A 400
GLY A 163
ALA A 164
HIS A 196
 EDO  A 410 (-3.7A)
None
None
EDO  A 410 (-3.5A)
 0.99A 1wrqA-2py6A:
undetectable		 1wrqA-2py6A:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w9m POLYMERASE X

(Deinococcus
radiodurans) 		PF14520
(HHH_5)
PF14716
(HHH_8) 		4 ARG A 494
GLY A  90
ALA A  88
HIS A 428
 ZN  A1567 ( 4.8A)
None
None
ZN  A1567 (-3.4A)
 0.93A 1wrqA-2w9mA:
undetectable		 1wrqA-2w9mA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x8u SERINE
PALMITOYLTRANSFERASE

(Sphingomonas
wittichii) 		PF00155
(Aminotran_1_2) 		4 ARG A 394
ILE A 399
GLY A 393
ALA A 392
 None
 0.93A 1wrqA-2x8uA:
undetectable		 1wrqA-2x8uA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yw9 ENOYL-[ACYL CARRIER
PROTEIN] REDUCTASE

(Thermus
thermophilus) 		PF13561
(adh_short_C2) 		4 ILE A 254
GLY A 251
ALA A 250
HIS A 253
 None
 0.86A 1wrqA-2yw9A:
undetectable		 1wrqA-2yw9A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z3b ATP-DEPENDENT
PROTEASE HSLV

(Bacillus
subtilis) 		PF00227
(Proteasome) 		4 ARG A 140
ILE A 125
GLY A 139
ALA A 138
 None
 1.00A 1wrqA-2z3bA:
undetectable		 1wrqA-2z3bA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ada SARCOSINE OXIDASE
BETA SUBUNIT

(Corynebacterium
sp. U-96) 		PF01266
(DAO) 		4 ARG B 104
ILE B 169
GLY B 168
ALA B 167
 None
 0.99A 1wrqA-3adaB:
undetectable		 1wrqA-3adaB:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1r RIBOKINASE, PUTATIVE

(Burkholderia
thailandensis) 		PF00294
(PfkB) 		4 ARG A 274
ILE A 237
GLY A 273
ALA A 272
 None
 0.95A 1wrqA-3b1rA:
undetectable		 1wrqA-3b1rA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bh0 DNAB-LIKE
REPLICATIVE HELICASE

(Bacillus phage
SPP1) 		PF03796
(DnaB_C) 		4 ARG A 258
ILE A 249
GLY A 247
ALA A 246
 None
 0.97A 1wrqA-3bh0A:
undetectable		 1wrqA-3bh0A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bj1 HEMOGLOBIN ALPHA

(Perca
flavescens) 		PF00042
(Globin) 		4 ILE A  63
GLY A  60
ALA A  26
HIS A  59
 HEM  A 143 (-4.1A)
None
None
HEM  A 143 (-4.2A)
 0.96A 1wrqA-3bj1A:
undetectable		 1wrqA-3bj1A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3buj CALO2

(Micromonospora
echinospora) 		PF00067
(p450) 		4 ARG A 296
ARG A  30
GLY A  31
ALA A  32
 None
 1.01A 1wrqA-3bujA:
undetectable		 1wrqA-3bujA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clh 3-DEHYDROQUINATE
SYNTHASE

(Helicobacter
pylori) 		PF01761
(DHQ_synthase) 		4 ILE A 252
GLY A 249
ALA A 170
HIS A 248
 None
None
None
ZN  A 344 (-2.9A)
 0.90A 1wrqA-3clhA:
undetectable		 1wrqA-3clhA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d0q PROTEIN CALG3

(Micromonospora
echinospora) 		PF06722
(DUF1205) 		4 ARG A  23
GLY A  26
ALA A  25
HIS A  -2
 None
 0.95A 1wrqA-3d0qA:
undetectable		 1wrqA-3d0qA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edm SHORT CHAIN
DEHYDROGENASE

(Agrobacterium
fabrum) 		PF13561
(adh_short_C2) 		4 ARG A  16
GLY A  13
ALA A  14
HIS A  90
 None
 1.00A 1wrqA-3edmA:
undetectable		 1wrqA-3edmA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edm SHORT CHAIN
DEHYDROGENASE

(Agrobacterium
fabrum) 		PF13561
(adh_short_C2) 		4 ARG A 168
ARG A 146
GLY A 145
ALA A 144
 None
 0.92A 1wrqA-3edmA:
undetectable		 1wrqA-3edmA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Entamoeba
histolytica;
Thermoanaerobacter
brockii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ILE A  86
GLY A 109
ALA A 108
HIS A 100
 None
 0.66A 1wrqA-3fpcA:
undetectable		 1wrqA-3fpcA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fsr NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Clostridium
beijerinckii;
Thermoanaerobacter
brockii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ILE A  86
GLY A 109
ALA A 108
HIS A 100
 None
 0.63A 1wrqA-3fsrA:
undetectable		 1wrqA-3fsrA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdc MULTICOPPER OXIDASE

(Arthrobacter
sp. FB24) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ARG A 169
ILE A 266
GLY A 265
HIS A 219
 None
 0.94A 1wrqA-3gdcA:
undetectable		 1wrqA-3gdcA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hyk HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE

(Bacillus
anthracis) 		PF01648
(ACPS) 		4 ARG A  53
ILE A 101
GLY A  52
HIS A 103
 A3P  A 124 (-3.3A)
A3P  A 124 (-3.8A)
None
MG  A 120 ( 3.3A)
 0.95A 1wrqA-3hykA:
undetectable		 1wrqA-3hykA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3id6 PRE MRNA SPLICING
PROTEIN

(Sulfolobus
solfataricus) 		PF01798
(Nop) 		4 ILE A  11
GLY A  12
ALA A  13
HIS A   9
 None
 0.99A 1wrqA-3id6A:
undetectable		 1wrqA-3id6A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ik2 ENDOGLUCANASE A

(Clostridium
acetobutylicum) 		PF12891
(Glyco_hydro_44) 		4 ILE A 191
GLY A 106
ALA A 105
HIS A 188
 None
 0.92A 1wrqA-3ik2A:
undetectable		 1wrqA-3ik2A:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1c ENVELOPE
GLYCOPROTEIN H

(Human
alphaherpesvirus
2) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		4 ARG A 545
ILE A 549
GLY A 546
ALA A 543
 None
 0.96A 1wrqA-3m1cA:
undetectable		 1wrqA-3m1cA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mcx SUSD SUPERFAMILY
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 ARG A  87
GLY A 295
ALA A 296
HIS A  58
 GOL  A  12 (-2.6A)
None
None
None
 0.87A 1wrqA-3mcxA:
undetectable		 1wrqA-3mcxA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myr NICKEL-DEPENDENT
HYDROGENASE LARGE
SUBUNIT

(Allochromatium
vinosum) 		PF00374
(NiFeSe_Hases) 		4 ARG B1074
ILE B1482
GLY B1481
ALA B1075
 None
 1.01A 1wrqA-3myrB:
undetectable		 1wrqA-3myrB:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myr NICKEL-DEPENDENT
HYDROGENASE LARGE
SUBUNIT

(Allochromatium
vinosum) 		PF00374
(NiFeSe_Hases) 		4 ARG B1302
ILE B1482
GLY B1481
ALA B1075
 None
 0.87A 1wrqA-3myrB:
undetectable		 1wrqA-3myrB:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n00 REV-ERBA-ALPHA
NUCLEAR RECEPTOR
COREPRESSOR 1

(Homo sapiens;
Homo sapiens) 		PF00104
(Hormone_recep)
no annotation 		4 ARG A 448
ILE B2058
ALA A 446
HIS B2054
 None
 0.95A 1wrqA-3n00A:
undetectable		 1wrqA-3n00A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ne9 PHOSPHOPANTETHEINE
PROTEIN TRANSFERASE,
PPT1P

(Corynebacterium
ammoniagenes) 		PF01648
(ACPS) 		4 ARG A  69
ILE A 136
GLY A  68
ALA A  67
 None
 0.86A 1wrqA-3ne9A:
undetectable		 1wrqA-3ne9A:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntx CYTOPLASMIC
L-ASPARAGINASE I

(Yersinia pestis) 		PF00710
(Asparaginase) 		4 ILE A 185
GLY A 184
ALA A 183
HIS A 186
 None
 0.97A 1wrqA-3ntxA:
undetectable		 1wrqA-3ntxA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pe0 PLECTIN

(Homo sapiens) 		PF00435
(Spectrin) 		4 ARG A 814
GLY A 810
ALA A 812
HIS A 807
 None
 0.92A 1wrqA-3pe0A:
undetectable		 1wrqA-3pe0A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r5t FERRIC VIBRIOBACTIN
ABC TRANSPORTER,
PERIPLASMIC FERRIC
VIBRIOBACTIN-BINDING
PROTEIN

(Vibrio cholerae) 		PF01497
(Peripla_BP_2) 		4 ILE A 123
GLY A 124
ALA A 125
HIS A 239
 VBN  A   1 ( 4.8A)
VBN  A   1 (-3.3A)
VBN  A   1 (-3.4A)
VBN  A   1 (-4.1A)
 0.97A 1wrqA-3r5tA:
undetectable		 1wrqA-3r5tA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swd UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Escherichia
coli) 		PF00275
(EPSP_synthase) 		4 ARG A 120
ILE A 117
GLY A 118
ALA A 119
 EPZ  A 501 (-4.1A)
QPA  A 115 ( 4.4A)
QPA  A 115 ( 4.2A)
None
 0.81A 1wrqA-3swdA:
undetectable		 1wrqA-3swdA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae) 		PF00275
(EPSP_synthase) 		4 ARG A 122
ILE A 119
GLY A 120
ALA A 121
 EPZ  A 508 (-3.9A)
QPA  A 117 ( 4.4A)
QPA  A 117 ( 4.0A)
None
 0.88A 1wrqA-3sweA:
undetectable		 1wrqA-3sweA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swg UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Aquifex
aeolicus) 		PF00275
(EPSP_synthase) 		4 ARG A 129
ILE A 126
GLY A 127
ALA A 128
 EPZ  A 518 (-4.0A)
QPA  A 124 ( 4.0A)
QPA  A 124 ( 3.6A)
None
 0.94A 1wrqA-3swgA:
undetectable		 1wrqA-3swgA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u43 COLICIN-E2

(Escherichia
coli) 		no annotation 4 ARG B 126
GLY B  31
ALA B  26
HIS B 102
 None
None
None
ZN  B 135 (-3.2A)
 0.91A 1wrqA-3u43B:
undetectable		 1wrqA-3u43B:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uko ALCOHOL
DEHYDROGENASE
CLASS-3

(Arabidopsis
thaliana) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ILE A  74
GLY A  73
ALA A  72
HIS A  90
 None
 1.00A 1wrqA-3ukoA:
undetectable		 1wrqA-3ukoA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3urr PTS IIA-LIKE
NITROGEN-REGULATORY
PROTEIN PTSN

(Burkholderia
thailandensis) 		PF00359
(PTS_EIIA_2) 		4 ARG A  82
ILE A  15
GLY A  16
ALA A  84
 None
 0.95A 1wrqA-3urrA:
undetectable		 1wrqA-3urrA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vcy UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Aliivibrio
fischeri) 		PF00275
(EPSP_synthase) 		4 ARG A 121
ILE A 118
GLY A 119
ALA A 120
 PO4  A 502 (-3.0A)
None
None
None
 0.82A 1wrqA-3vcyA:
undetectable		 1wrqA-3vcyA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vu2 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME,
CHLOROPLASTIC/AMYLOP
LASTIC

(Oryza sativa) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		4 ARG A 125
ILE A  82
GLY A  90
ALA A  91
 None
 0.97A 1wrqA-3vu2A:
undetectable		 1wrqA-3vu2A:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccd GALACTOCEREBROSIDASE

(Mus musculus) 		PF02057
(Glyco_hydro_59)
PF17387
(Glyco_hydro_59M) 		4 ILE A  42
GLY A  43
ALA A  44
HIS A  80
 None
 0.99A 1wrqA-4ccdA:
undetectable		 1wrqA-4ccdA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d9i DIAMINOPROPIONATE
AMMONIA-LYASE

(Escherichia
coli) 		PF00291
(PALP) 		4 ILE A 202
GLY A  81
ALA A  82
HIS A 123
 None
LLP  A  77 ( 4.0A)
None
None
 0.84A 1wrqA-4d9iA:
undetectable		 1wrqA-4d9iA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dje CORRINOID/IRON-SULFU
R PROTEIN SMALL
SUBUNIT

(Moorella
thermoacetica) 		PF03599
(CdhD) 		4 ILE D 281
GLY D 280
ALA D 263
HIS D 303
 None
 0.98A 1wrqA-4djeD:
undetectable		 1wrqA-4djeD:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e6p PROBABLE SORBITOL
DEHYDROGENASE
(L-IDITOL
2-DEHYDROGENASE)

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		4 ARG A 144
ILE A 161
GLY A 143
ALA A 142
 None
None
None
EDO  A 302 (-3.6A)
 0.84A 1wrqA-4e6pA:
undetectable		 1wrqA-4e6pA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fer EXPANSIN-YOAJ

(Bacillus
subtilis) 		PF03330
(DPBB_1) 		4 ARG A  78
GLY A  79
ALA A  80
HIS A   7
 SO4  A 303 (-3.0A)
None
None
None
 0.97A 1wrqA-4ferA:
undetectable		 1wrqA-4ferA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n1a CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata) 		PF01580
(FtsK_SpoIIIE) 		4 ARG A 842
ILE A1049
GLY A 871
ALA A 870
 None
 0.90A 1wrqA-4n1aA:
undetectable		 1wrqA-4n1aA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata) 		PF01580
(FtsK_SpoIIIE) 		4 ARG A 842
ILE A1049
GLY A 871
ALA A 870
 None
 0.88A 1wrqA-4nh0A:
undetectable		 1wrqA-4nh0A:
8.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4okq HUT OPERON POSITIVE
REGULATORY PROTEIN

(Geobacillus
thermodenitrificans) 		PF09021
(HutP) 		6 ARG A  89
ARG A  99
ILE A 130
GLY A 131
ALA A 132
HIS A 139
 None
 0.25A 1wrqA-4okqA:
24.0		 1wrqA-4okqA:
57.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p62 METALLO-BETA-LACTAMA
SE AIM-1

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B) 		4 ILE A  58
GLY A  57
ALA A  35
HIS A 250
 None
None
None
ZN  A 302 (-3.1A)
 0.90A 1wrqA-4p62A:
undetectable		 1wrqA-4p62A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7u UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Vibrio cholerae) 		PF00275
(EPSP_synthase) 		4 ARG A 121
ILE A 118
GLY A 119
ALA A 120
 UD1  A 503 (-3.8A)
None
None
None
 0.86A 1wrqA-4r7uA:
undetectable		 1wrqA-4r7uA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9x COPPER HOMEOSTASIS
PROTEIN CUTC

(Bacillus
anthracis) 		PF03932
(CutC) 		4 ILE A   5
GLY A 199
ALA A 201
HIS A 197
 None
 0.84A 1wrqA-4r9xA:
undetectable		 1wrqA-4r9xA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE

(Mycobacterium
avium) 		PF00289
(Biotin_carb_N)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ARG A 254
ILE A 330
GLY A 329
ALA A 328
 None
 0.99A 1wrqA-4rcnA:
undetectable		 1wrqA-4rcnA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tzn PROTEIN HTP-2

(Caenorhabditis
elegans) 		PF02301
(HORMA) 		4 ARG A  94
ILE A  43
GLY A  97
ALA A  96
 None
 0.95A 1wrqA-4tznA:
undetectable		 1wrqA-4tznA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xcv NADP-DEPENDENT
2-HYDROXYACID
DEHYDROGENASE

(Rhizobium etli) 		PF02826
(2-Hacid_dh_C) 		4 ARG A 315
ILE A  80
GLY A 318
ALA A 317
 None
 0.98A 1wrqA-4xcvA:
undetectable		 1wrqA-4xcvA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9l PROTEIN ACDH-11,
ISOFORM B

(Caenorhabditis
elegans) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M) 		4 ARG A 143
ILE A 332
GLY A 169
ALA A 170
 None
 0.97A 1wrqA-4y9lA:
undetectable		 1wrqA-4y9lA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yei BETA1MUT

(synthetic
construct) 		PF00805
(Pentapeptide) 		4 ARG A  69
GLY A  89
ALA A  90
HIS A 108
 None
 0.94A 1wrqA-4yeiA:
undetectable		 1wrqA-4yeiA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yqy PUTATIVE
DEHYDROGENASE

(Sulfitobacter
sp. NAS-14.1) 		PF13561
(adh_short_C2) 		4 ARG A 167
ARG A 145
GLY A 144
ALA A 143
 None
 0.97A 1wrqA-4yqyA:
undetectable		 1wrqA-4yqyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yyf BETA-N-ACETYLHEXOSAM
INIDASE

(Mycolicibacterium
smegmatis) 		PF00933
(Glyco_hydro_3) 		4 ARG A 195
ILE A 192
GLY A 193
ALA A 188
 ACT  A 401 (-2.8A)
None
None
None
 0.87A 1wrqA-4yyfA:
undetectable		 1wrqA-4yyfA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zon VERRUCULOGEN
SYNTHASE

(Aspergillus
fumigatus) 		PF05721
(PhyH) 		4 ARG A 117
ILE A 119
GLY A 209
ALA A 125
 None
 0.93A 1wrqA-4zonA:
undetectable		 1wrqA-4zonA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zqv CDII IMMUNITY
PROTEIN

(Yersinia
kristensenii) 		PF07262
(CdiI) 		4 ARG A 157
ILE A  50
GLY A 153
ALA A 154
 None
 0.80A 1wrqA-4zqvA:
undetectable		 1wrqA-4zqvA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxg GLUTATHIONE
S-TRANSFERASE

(Plasmodium
falciparum) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 ARG A  13
GLY A  14
ALA A  16
HIS A 107
 None
 0.98A 1wrqA-4zxgA:
undetectable		 1wrqA-4zxgA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chl HISTONE H2A.Z

(Homo sapiens) 		PF00125
(Histone)
PF16211
(Histone_H2A_C) 		4 ARG B  55
ARG B 119
GLY B 121
ALA B 122
 None
 0.82A 1wrqA-5chlB:
undetectable		 1wrqA-5chlB:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7q ACYL-COA SYNTHETASE

(Streptomyces
platensis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 ARG A  53
ILE A 160
GLY A  78
ALA A  79
 SO4  A 702 (-4.3A)
None
None
None
 0.96A 1wrqA-5e7qA:
undetectable		 1wrqA-5e7qA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ej1 PUTATIVE CELLULOSE
SYNTHASE

(Rhodobacter
sphaeroides) 		PF00535
(Glycos_transf_2)
PF03552
(Cellulose_synt)
PF07238
(PilZ) 		4 ARG A 705
ILE A 707
GLY A 712
ALA A 714
 None
None
None
3PE  A 923 ( 4.4A)
 0.91A 1wrqA-5ej1A:
undetectable		 1wrqA-5ej1A:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ejj UFM1-SPECIFIC
PROTEASE

(Caenorhabditis
elegans) 		PF07910
(Peptidase_C78) 		4 ARG A  51
ILE A  84
GLY A  50
HIS A  59
 None
 0.85A 1wrqA-5ejjA:
undetectable		 1wrqA-5ejjA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5enz UDP-GLCNAC
2-EPIMERASE

(Staphylococcus
aureus) 		PF02350
(Epimerase_2) 		4 ARG A 136
GLY A 120
ALA A 119
HIS A 156
 None
 0.99A 1wrqA-5enzA:
undetectable		 1wrqA-5enzA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f0l VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 26A

(Homo sapiens) 		PF03643
(Vps26) 		4 ARG B 127
ILE B 122
GLY B 123
ALA B 124
 EDO  B 411 (-4.9A)
None
EDO  B 410 ( 4.0A)
EDO  B 410 ( 4.1A)
 0.94A 1wrqA-5f0lB:
undetectable		 1wrqA-5f0lB:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h6s AMIDASE

(Microbacterium
sp. HM58-2) 		PF01425
(Amidase) 		4 ARG A 444
ILE A 227
GLY A 443
ALA A 442
 None
 0.91A 1wrqA-5h6sA:
undetectable		 1wrqA-5h6sA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hjn LD10117P

(Drosophila
melanogaster) 		PF00566
(RabGAP-TBC) 		4 ARG A 281
ILE A 334
ALA A 283
HIS A 227
 SO4  A 401 (-3.4A)
None
None
None
 1.00A 1wrqA-5hjnA:
undetectable		 1wrqA-5hjnA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hrm HALOALKYLPHOSPHORUS
HYDROLASE

(Sphingobium sp.
TCM1) 		no annotation 4 ARG A 226
ILE A 223
GLY A 222
ALA A 231
 None
 1.00A 1wrqA-5hrmA:
undetectable		 1wrqA-5hrmA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i92 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Pseudomonas
aeruginosa) 		PF00202
(Aminotran_3) 		4 ARG A 244
GLY A 352
ALA A 351
HIS A 321
 None
 1.01A 1wrqA-5i92A:
undetectable		 1wrqA-5i92A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iaa UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 5
UBIQUITIN-FOLD
MODIFIER 1

(Homo sapiens;
Homo sapiens) 		PF00899
(ThiF)
PF03671
(Ufm1) 		4 ILE C  55
GLY C  56
ALA A 230
HIS C  70
 None
 0.96A 1wrqA-5iaaC:
undetectable		 1wrqA-5iaaC:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1f PLECTIN,PLECTIN

(Homo sapiens) 		no annotation 4 ARG A 814
GLY A 810
ALA A 812
HIS A 807
 None
 0.95A 1wrqA-5j1fA:
undetectable		 1wrqA-5j1fA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jb3 30S RIBOSOMAL
PROTEIN S2

(Pyrococcus
abyssi) 		PF00318
(Ribosomal_S2) 		4 ARG B  36
ILE B  19
GLY B  16
ALA B  15
 None
 0.94A 1wrqA-5jb3B:
undetectable		 1wrqA-5jb3B:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jgg ALPHA CHAIN

(Acipenser
persicus) 		PF00042
(Globin) 		4 ILE A  63
GLY A  60
ALA A  26
HIS A  59
 HEM  A 201 ( 4.7A)
None
None
HEM  A 201 (-4.0A)
 0.99A 1wrqA-5jggA:
undetectable		 1wrqA-5jggA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjh 4-ALPHA-GLUCANOTRANS
FERASE

(Corynebacterium
glutamicum) 		PF02446
(Glyco_hydro_77) 		4 ARG A 334
GLY A 395
ALA A 396
HIS A 392
 None
 0.89A 1wrqA-5jjhA:
undetectable		 1wrqA-5jjhA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jnz ALPHA CHAIN

(Acipenser
stellatus) 		PF00042
(Globin) 		4 ILE A  63
GLY A  60
ALA A  26
HIS A  59
 HEM  A 201 ( 4.6A)
None
None
HEM  A 201 (-3.9A)
 0.98A 1wrqA-5jnzA:
undetectable		 1wrqA-5jnzA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lbk COPPER-TRANSPORTING
ATPASE PAA2,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		no annotation 4 ARG A 676
ILE A 682
GLY A 675
ALA A 627
 None
 0.88A 1wrqA-5lbkA:
undetectable		 1wrqA-5lbkA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mea CELL DIVISION CYCLE
PROTEIN CDT1

(Saccharomyces
cerevisiae) 		no annotation 4 ARG A 238
ILE A 270
GLY A 276
HIS A 281
 SO4  A 501 ( 2.4A)
SO4  A 501 ( 4.2A)
SO4  A 501 ( 4.1A)
SO4  A 501 (-4.0A)
 0.97A 1wrqA-5meaA:
1.3		 1wrqA-5meaA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujz HEMAGGLUTININ HA1

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 ARG A 192
ILE A 188
GLY A 189
ALA A 193
 None
 0.93A 1wrqA-5ujzA:
undetectable		 1wrqA-5ujzA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vf5 SM80.1 VICILIN

(Solanum
melongena) 		no annotation 4 ILE A 330
GLY A 395
ALA A 394
HIS A 398
 None
PEG  A 504 (-4.6A)
PEG  A 504 ( 3.8A)
None
 0.98A 1wrqA-5vf5A:
undetectable		 1wrqA-5vf5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vj1 MDCA

(Pseudomonas
aeruginosa) 		PF16957
(Mal_decarbox_Al) 		4 ILE A 356
GLY A 357
ALA A 358
HIS A 259
 None
 0.81A 1wrqA-5vj1A:
undetectable		 1wrqA-5vj1A:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vvh OCTOPINE
CATABOLISM/UPTAKE
OPERON REGULATORY
PROTEIN OCCR

(Agrobacterium
tumefaciens) 		PF03466
(LysR_substrate) 		4 ILE A 234
GLY A 233
ALA A 232
HIS A 172
 None
 0.87A 1wrqA-5vvhA:
undetectable		 1wrqA-5vvhA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3r PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1

(Mus musculus) 		no annotation 4 ARG A1538
ARG A1159
ILE A1144
HIS A1145
 None
 0.92A 1wrqA-6b3rA:
undetectable		 1wrqA-6b3rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byw GOXA

(Pseudoalteromonas
luteoviolacea) 		no annotation 4 ILE B 507
GLY B 506
ALA B 216
HIS B 583
 None
 0.97A 1wrqA-6bywB:
undetectable		 1wrqA-6bywB:
undetectable