SIMILAR PATTERNS OF AMINO ACIDS FOR 1WRL_F_TFPF211_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ctt CYTIDINE DEAMINASE

(Escherichia
coli) 		PF00383
(dCMP_cyt_deam_1)
PF08211
(dCMP_cyt_deam_2) 		4 LEU A  59
PHE A  86
LEU A  24
SER A  40
 None
 0.84A 1wrlE-1cttA:
0.0
1wrlF-1cttA:
undetectable		 1wrlE-1cttA:
15.73
1wrlF-1cttA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgp ARISTOLOCHENE
SYNTHASE

(Penicillium
roqueforti) 		no annotation 4 LEU A 108
PHE A 112
LEU A 209
SER A 334
 FOH  A 402 (-4.2A)
FOH  A 402 ( 3.7A)
FOH  A 402 (-4.4A)
None
 0.95A 1wrlE-1dgpA:
0.0
1wrlF-1dgpA:
0.0		 1wrlE-1dgpA:
15.33
1wrlF-1dgpA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgr CANAVALIN

(Canavalia
ensiformis) 		PF00190
(Cupin_1) 		4 LEU A  99
PHE A 176
LEU A  67
SER A 106
 None
 0.99A 1wrlE-1dgrA:
undetectable
1wrlF-1dgrA:
undetectable		 1wrlE-1dgrA:
15.93
1wrlF-1dgrA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dkg MOLECULAR CHAPERONE
DNAK

(Escherichia
coli) 		PF00012
(HSP70) 		4 PHE D  67
PHE D  91
MET D  89
SER D  87
 None
 1.05A 1wrlE-1dkgD:
undetectable
1wrlF-1dkgD:
0.0		 1wrlE-1dkgD:
14.67
1wrlF-1dkgD:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dmw PHENYLALANINE
HYDROXYLASE

(Homo sapiens) 		PF00351
(Biopterin_H) 		4 LEU A 258
PHE A 302
PHE A 294
PHE A 299
 None
 0.95A 1wrlE-1dmwA:
0.0
1wrlF-1dmwA:
undetectable		 1wrlE-1dmwA:
15.77
1wrlF-1dmwA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e50 CORE-BINDING FACTOR
CBF-BETA

(Homo sapiens) 		PF02312
(CBF_beta) 		4 LEU B 103
PHE B  12
PHE B  17
LEU B  64
 None
 1.04A 1wrlE-1e50B:
undetectable
1wrlF-1e50B:
undetectable		 1wrlE-1e50B:
22.30
1wrlF-1e50B:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fbl FIBROBLAST
(INTERSTITIAL)
COLLAGENASE (MMP-1)

(Sus scrofa) 		PF00045
(Hemopexin)
PF00413
(Peptidase_M10) 		4 LEU A 294
PHE A 284
PHE A 430
PHE A 439
 None
 0.91A 1wrlE-1fblA:
undetectable
1wrlF-1fblA:
undetectable		 1wrlE-1fblA:
15.19
1wrlF-1fblA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ff9 SACCHAROPINE
REDUCTASE

(Magnaporthe
grisea) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		4 LEU A 258
PHE A 254
LEU A 344
SER A 326
 None
 0.96A 1wrlE-1ff9A:
0.0
1wrlF-1ff9A:
0.0		 1wrlE-1ff9A:
10.89
1wrlF-1ff9A:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i4e CASPASE-8

(Homo sapiens) 		PF00656
(Peptidase_C14) 		4 LEU B2400
PHE B2356
LEU B2443
PHE B2274
 None
 1.01A 1wrlE-1i4eB:
undetectable
1wrlF-1i4eB:
0.0		 1wrlE-1i4eB:
19.66
1wrlF-1i4eB:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nty TRIPLE FUNCTIONAL
DOMAIN PROTEIN

(Homo sapiens) 		PF00169
(PH)
PF00621
(RhoGEF) 		4 PHE A1296
LEU A1241
PHE A1321
MET A1398
 None
 1.00A 1wrlE-1ntyA:
undetectable
1wrlF-1ntyA:
undetectable		 1wrlE-1ntyA:
17.19
1wrlF-1ntyA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obh LEUCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2)
PF14795
(Leucyl-specific) 		4 LEU A 141
LEU A 452
PHE A 502
MET A 498
 None
 0.87A 1wrlE-1obhA:
undetectable
1wrlF-1obhA:
undetectable		 1wrlE-1obhA:
6.82
1wrlF-1obhA:
6.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1phz PROTEIN
(PHENYLALANINE
HYDROXYLASE)

(Rattus
norvegicus) 		PF00351
(Biopterin_H)
PF01842
(ACT) 		4 LEU A 258
PHE A 302
PHE A 294
PHE A 299
 None
 0.92A 1wrlE-1phzA:
undetectable
1wrlF-1phzA:
undetectable		 1wrlE-1phzA:
12.62
1wrlF-1phzA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q6y HYPOTHETICAL PROTEIN
YFDW

(Escherichia
coli) 		PF02515
(CoA_transf_3) 		4 LEU A 183
LEU A  28
PHE A 378
MET A 376
 None
 0.95A 1wrlE-1q6yA:
undetectable
1wrlF-1q6yA:
undetectable		 1wrlE-1q6yA:
12.78
1wrlF-1q6yA:
12.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wrk TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES

(Homo sapiens) 		PF13833
(EF-hand_8) 		5 PHE A  20
PHE A  27
LEU A  48
PHE A  77
MET A  81
 TFP  A 204 ( 4.6A)
TFP  A 204 (-4.4A)
TFP  A 202 (-4.1A)
None
TFP  A 202 ( 3.3A)
 0.32A 1wrlE-1wrkA:
17.6
1wrlF-1wrkA:
16.5		 1wrlE-1wrkA:
100.00
1wrlF-1wrkA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy9 ALLOGRAFT
INFLAMMATORY FACTOR
1

(Mus musculus) 		no annotation 4 PHE A  50
PHE A  57
PHE A 106
MET A 110
 None
 0.93A 1wrlE-1wy9A:
7.3
1wrlF-1wy9A:
7.4		 1wrlE-1wy9A:
25.34
1wrlF-1wy9A:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyr RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 6

(Homo sapiens) 		PF00307
(CH) 		4 LEU A  39
PHE A  34
PHE A 100
LEU A 107
 None
 0.95A 1wrlE-1wyrA:
undetectable
1wrlF-1wyrA:
undetectable		 1wrlE-1wyrA:
19.66
1wrlF-1wyrA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9n DNA LIGASE I

(Homo sapiens) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 LEU A 618
PHE A 693
LEU A 682
SER A 612
 None
 1.05A 1wrlE-1x9nA:
undetectable
1wrlF-1x9nA:
undetectable		 1wrlE-1x9nA:
8.16
1wrlF-1x9nA:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yrg GTPASE-ACTIVATING
PROTEIN RNA1_SCHPO

(Schizosaccharomyces
pombe) 		no annotation 4 LEU A 114
LEU A 129
PHE A  71
SER A  40
 None
 1.01A 1wrlE-1yrgA:
undetectable
1wrlF-1yrgA:
undetectable		 1wrlE-1yrgA:
12.87
1wrlF-1yrgA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zu4 FTSY

(Mycoplasma
mycoides) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		4 LEU A 116
PHE A 403
PHE A 162
SER A 172
 None
 0.93A 1wrlE-1zu4A:
undetectable
1wrlF-1zu4A:
1.6		 1wrlE-1zu4A:
15.48
1wrlF-1zu4A:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zyp ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F

(Salmonella
enterica) 		PF13192
(Thioredoxin_3) 		4 LEU A  83
PHE A  78
LEU A   2
PHE A  65
 None
 0.94A 1wrlE-1zypA:
undetectable
1wrlF-1zypA:
undetectable		 1wrlE-1zypA:
20.20
1wrlF-1zypA:
20.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2bl0 MYOSIN REGULATORY
LIGHT CHAIN

(Physarum
polycephalum) 		PF13833
(EF-hand_8) 		4 PHE C  20
PHE C  27
PHE C  76
MET C  80
 None
 0.52A 1wrlE-2bl0C:
9.2
1wrlF-2bl0C:
9.2		 1wrlE-2bl0C:
33.98
1wrlF-2bl0C:
33.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cav PROTEIN (CANAVALIN)

(Canavalia
ensiformis) 		PF00190
(Cupin_1) 		4 LEU A  99
PHE A 176
LEU A  67
SER A 106
 None
 0.93A 1wrlE-2cavA:
undetectable
1wrlF-2cavA:
undetectable		 1wrlE-2cavA:
11.19
1wrlF-2cavA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cex PROTEIN HI0146

(Haemophilus
influenzae) 		PF03480
(DctP) 		4 LEU A   5
PHE A  63
LEU A 226
PHE A  24
 None
 0.97A 1wrlE-2cexA:
undetectable
1wrlF-2cexA:
undetectable		 1wrlE-2cexA:
15.26
1wrlF-2cexA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2irm MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7
INTERACTING PROTEIN
1

(Anopheles
gambiae) 		PF00481
(PP2C) 		4 LEU A 178
LEU A 282
PHE A 107
SER A 164
 None
 0.88A 1wrlE-2irmA:
undetectable
1wrlF-2irmA:
undetectable		 1wrlE-2irmA:
15.56
1wrlF-2irmA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2is8 MOLYBDOPTERIN
BIOSYNTHESIS ENZYME,
MOAB

(Thermus
thermophilus) 		PF00994
(MoCF_biosynth) 		4 LEU A 124
PHE A   2
LEU A  95
PHE A  35
 None
 1.02A 1wrlE-2is8A:
undetectable
1wrlF-2is8A:
undetectable		 1wrlE-2is8A:
21.83
1wrlF-2is8A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ojh UNCHARACTERIZED
PROTEIN
ATU1656/AGR_C_3050

(Agrobacterium
fabrum) 		PF07676
(PD40) 		4 LEU A 122
LEU A 127
PHE A 141
MET A 156
 None
 0.93A 1wrlE-2ojhA:
undetectable
1wrlF-2ojhA:
undetectable		 1wrlE-2ojhA:
15.29
1wrlF-2ojhA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2onu UBIQUITIN-CONJUGATIN
G ENZYME, PUTATIVE

(Plasmodium
falciparum) 		PF00179
(UQ_con) 		4 LEU A 110
PHE A 105
PHE A  35
LEU A  71
 None
 0.98A 1wrlE-2onuA:
undetectable
1wrlF-2onuA:
undetectable		 1wrlE-2onuA:
18.79
1wrlF-2onuA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p25 GLYOXALASE FAMILY
PROTEIN

(Enterococcus
faecalis) 		PF00903
(Glyoxalase) 		4 LEU A  77
PHE A  79
LEU A  54
PHE A 114
 None
 0.98A 1wrlE-2p25A:
undetectable
1wrlF-2p25A:
undetectable		 1wrlE-2p25A:
25.60
1wrlF-2p25A:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1f CHONDROITINASE

(Bacteroides
thetaiotaomicron) 		PF02278
(Lyase_8)
PF09092
(Lyase_N)
PF09093
(Lyase_catalyt) 		4 LEU A 163
PHE A  25
LEU A  67
SER A  39
 None
 1.01A 1wrlE-2q1fA:
undetectable
1wrlF-2q1fA:
undetectable		 1wrlE-2q1fA:
6.67
1wrlF-2q1fA:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qib TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N) 		4 LEU A 137
PHE A 186
MET A 190
SER A 193
 None
P6G  A 703 (-4.1A)
None
None
 0.86A 1wrlE-2qibA:
undetectable
1wrlF-2qibA:
undetectable		 1wrlE-2qibA:
17.14
1wrlF-2qibA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qpx PREDICTED
METAL-DEPENDENT
HYDROLASE OF THE
TIM-BARREL FOLD

(Lactobacillus
paracasei) 		PF04909
(Amidohydro_2) 		4 LEU A 224
PHE A 252
PHE A 226
LEU A 129
 None
None
None
KCX  A 166 ( 3.8A)
 0.98A 1wrlE-2qpxA:
undetectable
1wrlF-2qpxA:
undetectable		 1wrlE-2qpxA:
11.41
1wrlF-2qpxA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rag DIPEPTIDASE

(Caulobacter
vibrioides) 		PF01244
(Peptidase_M19) 		4 LEU A 376
PHE A 336
MET A 340
SER A 342
 None
 0.94A 1wrlE-2ragA:
undetectable
1wrlF-2ragA:
undetectable		 1wrlE-2ragA:
11.82
1wrlF-2ragA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdy BH0842 PROTEIN

(Bacillus
halodurans) 		PF14498
(Glyco_hyd_65N_2) 		4 PHE A 484
PHE A 533
LEU A 497
SER A 502
 None
 0.99A 1wrlE-2rdyA:
undetectable
1wrlF-2rdyA:
undetectable		 1wrlE-2rdyA:
8.23
1wrlF-2rdyA:
8.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2w49 TROPONIN C, SKELETAL
MUSCLE

(Gallus gallus) 		PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		5 PHE 0  21
PHE 0  28
LEU 0  48
PHE 0  77
MET 0  81
 None
 0.93A 1wrlE-2w490:
13.0
1wrlF-2w490:
12.9		 1wrlE-2w490:
64.77
1wrlF-2w490:
64.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT

(Gallus gallus) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		4 LEU M 664
PHE M 249
LEU M 176
PHE M 458
 None
 1.05A 1wrlE-2w4gM:
undetectable
1wrlF-2w4gM:
undetectable		 1wrlE-2w4gM:
7.24
1wrlF-2w4gM:
7.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wqs AGGLUTININ RECEPTOR

(Streptococcus
gordonii) 		PF16364
(Antigen_C) 		4 LEU A1342
PHE A1361
LEU A1328
PHE A1305
 None
 0.73A 1wrlE-2wqsA:
undetectable
1wrlF-2wqsA:
undetectable		 1wrlE-2wqsA:
13.58
1wrlF-2wqsA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsw 72 KDA INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		4 LEU A 301
PHE A 413
PHE A 420
PHE A 411
 None
 0.95A 1wrlE-2xswA:
undetectable
1wrlF-2xswA:
undetectable		 1wrlE-2xswA:
16.67
1wrlF-2xswA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yt2 FIBROBLAST GROWTH
FACTOR RECEPTOR
SUBSTRATE 3 AND ALK
TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF02174
(IRS) 		4 LEU A 135
PHE A  89
LEU A  49
PHE A  74
 None
 0.72A 1wrlE-2yt2A:
undetectable
1wrlF-2yt2A:
undetectable		 1wrlE-2yt2A:
16.45
1wrlF-2yt2A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zfd CALCINEURIN B-LIKE
PROTEIN 2
PUTATIVE
UNCHARACTERIZED
PROTEIN T20L15_90

(Arabidopsis
thaliana) 		PF03822
(NAF)
PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		4 LEU A 111
PHE A  94
LEU B 327
PHE A 126
 None
 1.05A 1wrlE-2zfdA:
10.1
1wrlF-2zfdA:
10.1		 1wrlE-2zfdA:
20.00
1wrlF-2zfdA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqc COMPONENT A OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE

(Micrococcus
luteus) 		no annotation 4 LEU A  11
PHE A  21
LEU A  78
MET A  56
 None
 0.84A 1wrlE-3aqcA:
undetectable
1wrlF-3aqcA:
undetectable		 1wrlE-3aqcA:
20.00
1wrlF-3aqcA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8u PURR TRANSCRIPTIONAL
REGULATOR

(Vibrio
parahaemolyticus) 		PF13377
(Peripla_BP_3) 		4 LEU A 103
PHE A 122
LEU A  89
SER A 108
 None
 0.77A 1wrlE-3d8uA:
undetectable
1wrlF-3d8uA:
undetectable		 1wrlE-3d8uA:
15.30
1wrlF-3d8uA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmp URACIL
PHOSPHORIBOSYLTRANSF
ERASE

(Burkholderia
pseudomallei) 		PF14681
(UPRTase) 		4 LEU A 151
PHE A 163
LEU A 123
SER A  91
 None
 0.94A 1wrlE-3dmpA:
undetectable
1wrlF-3dmpA:
undetectable		 1wrlE-3dmpA:
17.35
1wrlF-3dmpA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ezs AMINOTRANSFERASE
ASPB

(Helicobacter
pylori) 		PF00155
(Aminotran_1_2) 		4 LEU A 364
PHE A 299
LEU A  27
SER A 308
 None
 1.06A 1wrlE-3ezsA:
undetectable
1wrlF-3ezsA:
undetectable		 1wrlE-3ezsA:
16.55
1wrlF-3ezsA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g87 MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Burkholderia
pseudomallei) 		PF00698
(Acyl_transf_1) 		4 LEU A 113
PHE A 207
LEU A 216
SER A 225
 None
 0.90A 1wrlE-3g87A:
undetectable
1wrlF-3g87A:
undetectable		 1wrlE-3g87A:
12.50
1wrlF-3g87A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdj HEMOGLOBIN SUBUNIT
ALPHA

(Camelus
dromedarius) 		PF00042
(Globin) 		4 LEU A  29
PHE A  46
PHE A  33
LEU A 101
 None
HEM  A 142 (-4.7A)
None
HEM  A 142 (-4.5A)
 1.00A 1wrlE-3gdjA:
undetectable
1wrlF-3gdjA:
undetectable		 1wrlE-3gdjA:
23.08
1wrlF-3gdjA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1w MANNOSE-6-PHOSPHATE
ISOMERASE

(Salmonella
enterica) 		PF01238
(PMI_typeI) 		4 LEU A 325
PHE A 344
PHE A 323
PHE A  85
 None
 0.95A 1wrlE-3h1wA:
undetectable
1wrlF-3h1wA:
undetectable		 1wrlE-3h1wA:
11.83
1wrlF-3h1wA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hs3 RIBOSE OPERON
REPRESSOR

(Lactobacillus
acidophilus) 		PF13377
(Peripla_BP_3) 		4 LEU A 133
PHE A 131
PHE A 125
SER A 142
 None
 1.02A 1wrlE-3hs3A:
undetectable
1wrlF-3hs3A:
undetectable		 1wrlE-3hs3A:
16.10
1wrlF-3hs3A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3v PROBABLE SECRETED
SOLUTE-BINDING
LIPOPROTEIN

(Streptomyces
coelicolor) 		PF01547
(SBP_bac_1) 		4 PHE A 322
LEU A  59
PHE A 338
MET A 342
 None
 0.99A 1wrlE-3i3vA:
undetectable
1wrlF-3i3vA:
undetectable		 1wrlE-3i3vA:
13.86
1wrlF-3i3vA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5g MYOSIN HEAVY CHAIN
ISOFORM A

(Doryteuthis
pealeii) 		PF00063
(Myosin_head)
PF00612
(IQ)
PF02736
(Myosin_N) 		4 LEU A 662
PHE A 251
LEU A 173
PHE A 458
 None
 1.03A 1wrlE-3i5gA:
undetectable
1wrlF-3i5gA:
undetectable		 1wrlE-3i5gA:
7.20
1wrlF-3i5gA:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l39 PUTATIVE PHOU-LIKE
PHOSPHATE REGULATORY
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF01865
(PhoU_div) 		4 LEU A 138
PHE A  79
LEU A 207
SER A  89
 None
 0.85A 1wrlE-3l39A:
undetectable
1wrlF-3l39A:
undetectable		 1wrlE-3l39A:
17.83
1wrlF-3l39A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE

(Ehrlichia
chaffeensis) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 LEU A 207
PHE A 288
LEU A 300
PHE A  90
 None
 0.95A 1wrlE-3lp8A:
undetectable
1wrlF-3lp8A:
undetectable		 1wrlE-3lp8A:
11.70
1wrlF-3lp8A:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lx2 DNA POLYMERASE
SLIDING CLAMP 2

(Thermococcus
kodakarensis) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 LEU A  20
PHE A  76
LEU A  51
PHE A  71
 None
 0.95A 1wrlE-3lx2A:
undetectable
1wrlF-3lx2A:
undetectable		 1wrlE-3lx2A:
17.90
1wrlF-3lx2A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nws CELL DIVISION
CONTROL PROTEIN 13

(Saccharomyces
cerevisiae) 		PF16853
(CDC13_N) 		4 LEU A  53
PHE A  55
LEU A  92
PHE A  37
 None
 0.94A 1wrlE-3nwsA:
undetectable
1wrlF-3nwsA:
undetectable		 1wrlE-3nwsA:
20.00
1wrlF-3nwsA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzu PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT GAMMA
ISOFORM

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd) 		4 LEU A 813
PHE A 815
LEU A 771
PHE A 783
 None
 0.85A 1wrlE-3nzuA:
undetectable
1wrlF-3nzuA:
undetectable		 1wrlE-3nzuA:
6.00
1wrlF-3nzuA:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1n GALACTOSE MUTAROTASE
RELATED ENZYME

(Lactobacillus
paracasei) 		PF01263
(Aldose_epim) 		4 LEU A  20
LEU A 121
PHE A  92
SER A  86
 None
None
None
NO3  A 297 (-4.1A)
 1.04A 1wrlE-3q1nA:
undetectable
1wrlF-3q1nA:
undetectable		 1wrlE-3q1nA:
19.91
1wrlF-3q1nA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q8d DNA REPAIR PROTEIN
RECO

(Escherichia
coli) 		PF02565
(RecO_C)
PF11967
(RecO_N) 		4 PHE A 183
PHE A 148
LEU A 139
PHE A 172
 None
 0.89A 1wrlE-3q8dA:
undetectable
1wrlF-3q8dA:
undetectable		 1wrlE-3q8dA:
16.25
1wrlF-3q8dA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sf6 GLUTARYL-COA
DEHYDROGENASE

(Mycolicibacterium
smegmatis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 LEU A 315
PHE A 263
LEU A  26
PHE A 259
 None
 1.07A 1wrlE-3sf6A:
undetectable
1wrlF-3sf6A:
undetectable		 1wrlE-3sf6A:
10.53
1wrlF-3sf6A:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6q CD180 ANTIGEN

(Mus musculus) 		PF13855
(LRR_8) 		4 LEU A 206
PHE A 224
PHE A 219
SER A 194
 None
GOL  A   3 (-4.2A)
None
None
 1.00A 1wrlE-3t6qA:
undetectable
1wrlF-3t6qA:
undetectable		 1wrlE-3t6qA:
9.64
1wrlF-3t6qA:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0k RCAMP

(Entacmaea
quadricolor) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		4 LEU A 333
LEU A 406
PHE A 435
MET A 439
 None
 0.78A 1wrlE-3u0kA:
10.3
1wrlF-3u0kA:
10.2		 1wrlE-3u0kA:
16.53
1wrlF-3u0kA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u44 ATP-DEPENDENT
HELICASE/DEOXYRIBONU
CLEASE SUBUNIT B

(Bacillus
subtilis) 		PF12705
(PDDEXK_1) 		4 LEU B 632
LEU B 158
PHE B 130
MET B 126
 None
 0.91A 1wrlE-3u44B:
undetectable
1wrlF-3u44B:
undetectable		 1wrlE-3u44B:
5.57
1wrlF-3u44B:
5.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vu9 CHROMOSOME
SEGREGATION IN
MEIOSIS PROTEIN 2

(Saccharomyces
cerevisiae) 		PF16834
(CSM2) 		4 LEU B 163
LEU B 143
MET B 122
SER B 126
 None
 1.06A 1wrlE-3vu9B:
undetectable
1wrlF-3vu9B:
undetectable		 1wrlE-3vu9B:
16.27
1wrlF-3vu9B:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4at0 3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E

(Rhodococcus
jostii) 		PF00890
(FAD_binding_2) 		4 LEU A 119
PHE A 126
LEU A 184
SER A 468
 None
None
None
ACT  A1490 (-2.6A)
 0.94A 1wrlE-4at0A:
0.4
1wrlF-4at0A:
0.4		 1wrlE-4at0A:
10.00
1wrlF-4at0A:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4djb E4-ORF3

(Human
mastadenovirus
C) 		PF06931
(Adeno_E4_ORF3) 		4 LEU A  61
PHE A 108
LEU A  32
SER A  86
 None
 0.92A 1wrlE-4djbA:
undetectable
1wrlF-4djbA:
undetectable		 1wrlE-4djbA:
20.77
1wrlF-4djbA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e9k HYPOTHETICAL PROTEIN

(Bacteroides
ovatus) 		PF14717
(DUF4465) 		4 LEU A 232
PHE A  76
PHE A 234
LEU A 223
 None
 1.05A 1wrlE-4e9kA:
undetectable
1wrlF-4e9kA:
undetectable		 1wrlE-4e9kA:
17.01
1wrlF-4e9kA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fjo MITOTIC SPINDLE
ASSEMBLY CHECKPOINT
PROTEIN MAD2B

(Mus musculus) 		PF02301
(HORMA) 		4 LEU C  23
PHE C 126
LEU C  75
SER C 194
 None
None
None
PO4  C 303 (-4.8A)
 0.99A 1wrlE-4fjoC:
undetectable
1wrlF-4fjoC:
undetectable		 1wrlE-4fjoC:
15.74
1wrlF-4fjoC:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gpc HEME OXYGENASE

(Corynebacterium
diphtheriae) 		PF01126
(Heme_oxygenase) 		4 LEU A 193
LEU A   8
PHE A  68
SER A  71
 None
 0.95A 1wrlE-4gpcA:
undetectable
1wrlF-4gpcA:
undetectable		 1wrlE-4gpcA:
16.74
1wrlF-4gpcA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1s 5'-NUCLEOTIDASE

(Homo sapiens) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		4 LEU A 501
PHE A 421
LEU A 450
MET A 368
 None
 1.01A 1wrlE-4h1sA:
undetectable
1wrlF-4h1sA:
undetectable		 1wrlE-4h1sA:
9.79
1wrlF-4h1sA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iw9 GLUTATHIONE
TRANSFERASE

(Mannheimia
haemolytica) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 LEU A 165
PHE A 100
PHE A 154
LEU A 185
 None
 0.86A 1wrlE-4iw9A:
undetectable
1wrlF-4iw9A:
undetectable		 1wrlE-4iw9A:
15.72
1wrlF-4iw9A:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4log MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN
AND NR2E3 PROTEIN
CHIMERIC CONSTRUCT

(Escherichia
coli;
Homo sapiens) 		PF00104
(Hormone_recep)
PF13416
(SBP_bac_8) 		4 LEU A1263
PHE A1310
LEU A1375
SER A1357
 None
 1.01A 1wrlE-4logA:
undetectable
1wrlF-4logA:
undetectable		 1wrlE-4logA:
12.08
1wrlF-4logA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfu SENESCENCE-ASSOCIATE
D CARBOXYLESTERASE
101

(Arabidopsis
thaliana) 		PF01764
(Lipase_3) 		4 LEU B  98
PHE B 106
LEU B 189
SER B 150
 None
 1.06A 1wrlE-4nfuB:
undetectable
1wrlF-4nfuB:
undetectable		 1wrlE-4nfuB:
9.26
1wrlF-4nfuB:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pd3 NONMUSCLE MYOSIN
HEAVY CHAIN B,
ALPHA-ACTININ A
CHIMERA PROTEIN

(Dictyostelium
discoideum;
Homo sapiens) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		4 LEU A 668
PHE A 245
LEU A 175
PHE A 454
 None
 1.06A 1wrlE-4pd3A:
undetectable
1wrlF-4pd3A:
undetectable		 1wrlE-4pd3A:
6.07
1wrlF-4pd3A:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pdx PUTATIVE
ALKYL/ARYL-SULFATASE
YJCS

(Escherichia
coli) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		4 LEU A 617
PHE A 554
LEU A 641
MET A 577
 None
 0.90A 1wrlE-4pdxA:
undetectable
1wrlF-4pdxA:
undetectable		 1wrlE-4pdxA:
9.82
1wrlF-4pdxA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tq5 PRENYLTRANSFERASE

(Archaeoglobus
fulgidus) 		PF01040
(UbiA) 		4 LEU A  54
LEU A  30
PHE A 125
MET A 129
 None
 1.04A 1wrlE-4tq5A:
undetectable
1wrlF-4tq5A:
undetectable		 1wrlE-4tq5A:
12.54
1wrlF-4tq5A:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ufc GH95

(Bacteroides
ovatus) 		PF14498
(Glyco_hyd_65N_2) 		4 LEU A 331
LEU A  24
PHE A 296
SER A 342
 None
 0.91A 1wrlE-4ufcA:
undetectable
1wrlF-4ufcA:
undetectable		 1wrlE-4ufcA:
8.45
1wrlF-4ufcA:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8h TOLL-RECEPTOR-RELATE
D 2

(Hydra vulgaris) 		PF13676
(TIR_2) 		4 LEU A 214
PHE A 210
LEU A 115
SER A 158
 None
 1.01A 1wrlE-4w8hA:
undetectable
1wrlF-4w8hA:
undetectable		 1wrlE-4w8hA:
21.54
1wrlF-4w8hA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd4 HEME OXYGENASE 1

(Homo sapiens) 		PF01126
(Heme_oxygenase) 		4 LEU A 164
PHE A  47
LEU A 157
PHE A  37
 None
 0.96A 1wrlE-4wd4A:
undetectable
1wrlF-4wd4A:
undetectable		 1wrlE-4wd4A:
14.24
1wrlF-4wd4A:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wlp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L5

(Homo sapiens) 		PF01088
(Peptidase_C12) 		4 PHE A  18
PHE A  25
LEU A 130
SER A 167
 None
 0.90A 1wrlE-4wlpA:
undetectable
1wrlF-4wlpA:
undetectable		 1wrlE-4wlpA:
14.29
1wrlF-4wlpA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xvg ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F

(Escherichia
coli) 		PF07992
(Pyr_redox_2)
PF13192
(Thioredoxin_3) 		4 LEU A  83
PHE A  78
LEU A   2
PHE A  65
 None
 0.91A 1wrlE-4xvgA:
undetectable
1wrlF-4xvgA:
undetectable		 1wrlE-4xvgA:
10.17
1wrlF-4xvgA:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ap9 LIPASE

(Thermomyces
lanuginosus) 		PF01764
(Lipase_3)
PF03893
(Lipase3_N) 		4 LEU A 159
PHE A 142
PHE A  80
SER A  58
 None
 0.94A 1wrlE-5ap9A:
undetectable
1wrlF-5ap9A:
undetectable		 1wrlE-5ap9A:
15.35
1wrlF-5ap9A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5esy SAL1 PHOSPHATASE

(Arabidopsis
thaliana) 		PF00459
(Inositol_P) 		4 LEU A 275
PHE A 228
LEU A 336
SER A 217
 None
 1.06A 1wrlE-5esyA:
undetectable
1wrlF-5esyA:
undetectable		 1wrlE-5esyA:
13.54
1wrlF-5esyA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyi NON-STRUCTURAL
PROTEIN 11

(Porcine
reproductive
and respiratory
syndrome virus) 		no annotation 4 LEU A  98
PHE A 205
LEU A  50
PHE A 103
 None
 0.86A 1wrlE-5eyiA:
undetectable
1wrlF-5eyiA:
undetectable		 1wrlE-5eyiA:
14.22
1wrlF-5eyiA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f64 POSITIVE
TRANSCRIPTION
REGULATOR EVGA

(Shigella
flexneri) 		PF00072
(Response_reg)
PF00196
(GerE) 		4 LEU A 156
LEU A 194
PHE A  86
SER A 143
 None
 1.06A 1wrlE-5f64A:
undetectable
1wrlF-5f64A:
undetectable		 1wrlE-5f64A:
20.10
1wrlF-5f64A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5id6 CPF1

(Lachnospiraceae
bacterium
ND2006) 		no annotation 4 LEU A1014
PHE A1027
LEU A1047
SER A1067
 None
 1.00A 1wrlE-5id6A:
undetectable
1wrlF-5id6A:
undetectable		 1wrlE-5id6A:
5.91
1wrlF-5id6A:
5.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j92 PUTATIVE ALPHA KG
DEPENDENT 2,4-D
DIOXYGENASE

(Paraburkholderia
xenovorans) 		PF02668
(TauD) 		4 LEU A  43
PHE A  45
PHE A  58
SER A  26
 None
 0.94A 1wrlE-5j92A:
undetectable
1wrlF-5j92A:
undetectable		 1wrlE-5j92A:
16.04
1wrlF-5j92A:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jm7 AEROBACTIN SYNTHASE
IUCA

(Klebsiella
pneumoniae) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		4 LEU A  83
LEU A  18
MET A 110
SER A 112
 None
 0.75A 1wrlE-5jm7A:
undetectable
1wrlF-5jm7A:
undetectable		 1wrlE-5jm7A:
10.20
1wrlF-5jm7A:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nr1 FTSZ-BINDING PROTEIN
FZLA

(Caulobacter
vibrioides) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		4 LEU A 217
PHE A 182
LEU A 125
SER A  16
 None
 0.86A 1wrlE-5nr1A:
undetectable
1wrlF-5nr1A:
undetectable		 1wrlE-5nr1A:
15.79
1wrlF-5nr1A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 LEU A3679
PHE A3614
LEU A3649
SER A2997
 None
 0.95A 1wrlE-5nugA:
undetectable
1wrlF-5nugA:
undetectable		 1wrlE-5nugA:
1.77
1wrlF-5nugA:
1.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o33 KALIRIN

(Rattus
norvegicus) 		PF00621
(RhoGEF) 		4 PHE B1296
LEU B1241
PHE B1321
MET B1398
 None
 1.00A 1wrlE-5o33B:
undetectable
1wrlF-5o33B:
undetectable		 1wrlE-5o33B:
17.68
1wrlF-5o33B:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oen INTERFERON
REGULATORY FACTOR 9

(Mus musculus) 		no annotation 4 LEU A 343
PHE A 218
PHE A 345
PHE A 253
 None
 0.96A 1wrlE-5oenA:
undetectable
1wrlF-5oenA:
undetectable		 1wrlE-5oenA:
20.00
1wrlF-5oenA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohs -

(-) 		no annotation 4 LEU A 102
PHE A 188
LEU A  20
SER A 172
 None
 0.79A 1wrlE-5ohsA:
undetectable
1wrlF-5ohsA:
undetectable		 1wrlE-5ohsA:
undetectable
1wrlF-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u39 UDP-3-O-ACYL-N-ACETY
LGLUCOSAMINE
DEACETYLASE

(Pseudomonas
aeruginosa) 		PF03331
(LpxC) 		4 LEU A  79
PHE A  39
LEU A  26
SER A  20
 None
 0.89A 1wrlE-5u39A:
undetectable
1wrlF-5u39A:
undetectable		 1wrlE-5u39A:
15.12
1wrlF-5u39A:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5va3 POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY H
MEMBER 2

(Homo sapiens) 		PF00027
(cNMP_binding)
PF00520
(Ion_trans)
PF13426
(PAS_9) 		4 LEU A 779
PHE A 781
LEU A 856
PHE A 758
 None
 1.00A 1wrlE-5va3A:
undetectable
1wrlF-5va3A:
undetectable		 1wrlE-5va3A:
9.21
1wrlF-5va3A:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vwm UDP-3-O-ACYL-N-ACETY
LGLUCOSAMINE
DEACETYLASE

(Pseudomonas
aeruginosa) 		PF03331
(LpxC) 		4 LEU A  79
PHE A  39
LEU A  26
SER A  20
 None
 0.94A 1wrlE-5vwmA:
undetectable
1wrlF-5vwmA:
undetectable		 1wrlE-5vwmA:
11.92
1wrlF-5vwmA:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1a MYOSIN HEAVY CHAIN,
MUSCLE

(Drosophila
melanogaster) 		no annotation 4 LEU A 663
PHE A 246
LEU A 176
PHE A 455
 None
 0.98A 1wrlE-5w1aA:
undetectable
1wrlF-5w1aA:
undetectable		 1wrlE-5w1aA:
20.22
1wrlF-5w1aA:
20.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w88 TROPONIN C, TROPONIN
I

(Homo sapiens) 		PF00992
(Troponin)
PF13833
(EF-hand_8) 		4 PHE A  20
LEU A  48
PHE A  77
MET A  81
 None
9XG  A 201 ( 4.8A)
9XG  A 201 (-3.8A)
9XG  A 201 ( 4.6A)
 0.92A 1wrlE-5w88A:
11.8
1wrlF-5w88A:
11.2		 1wrlE-5w88A:
100.00
1wrlF-5w88A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wfb AP-4 COMPLEX
ACCESSORY SUBUNIT
TEPSIN

(Homo sapiens) 		PF01417
(ENTH) 		4 LEU A  20
PHE A  13
LEU A  57
SER A  84
 None
 1.06A 1wrlE-5wfbA:
undetectable
1wrlF-5wfbA:
undetectable		 1wrlE-5wfbA:
17.56
1wrlF-5wfbA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wfi -

(-) 		no annotation 4 LEU A1730
PHE A1744
PHE A1732
LEU A1778
 None
 0.84A 1wrlE-5wfiA:
1.6
1wrlF-5wfiA:
undetectable		 1wrlE-5wfiA:
undetectable
1wrlF-5wfiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjs GEM-ASSOCIATED
PROTEIN 2

(Homo sapiens) 		no annotation 4 LEU 2 222
PHE 2 270
LEU 2 195
PHE 2 110
 None
 1.05A 1wrlE-5xjs2:
undetectable
1wrlF-5xjs2:
undetectable		 1wrlE-5xjs2:
22.34
1wrlF-5xjs2:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmr SERINE
HYDROXYMETHYLTRANSFE
RASE

(Plasmodium
vivax) 		no annotation 4 LEU A 246
PHE A 248
LEU A 285
PHE A 225
 None
 1.00A 1wrlE-5xmrA:
undetectable
1wrlF-5xmrA:
undetectable		 1wrlE-5xmrA:
10.86
1wrlF-5xmrA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f7s SERRATE RNA EFFECTOR
MOLECULE
HOMOLOG,SERRATE RNA
EFFECTOR MOLECULE
HOMOLOG

(Homo sapiens) 		no annotation 4 LEU C 439
PHE C 446
LEU C 491
PHE C 468
 None
 0.96A 1wrlE-6f7sC:
undetectable
1wrlF-6f7sC:
undetectable		 1wrlE-6f7sC:
20.45
1wrlF-6f7sC:
20.45