SIMILAR PATTERNS OF AMINO ACIDS FOR 1WRL_E_TFPE212

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a6c TOBACCO RINGSPOT
VIRUS CAPSID PROTEIN

(Tobacco
ringspot virus) 		PF03391
(Nepo_coat)
PF03688
(Nepo_coat_C)
PF03689
(Nepo_coat_N) 		4 PHE A  31
PHE A  78
LEU A 128
MET A 162
 None
 1.10A 1wrlE-1a6cA:
undetectable		 1wrlE-1a6cA:
12.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1avs TROPONIN C

(Gallus gallus) 		PF13833
(EF-hand_8) 		4 PHE A  22
PHE A  29
LEU A  49
PHE A  78
 None
 1.07A 1wrlE-1avsA:
13.2		 1wrlE-1avsA:
65.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1avs TROPONIN C

(Gallus gallus) 		PF13833
(EF-hand_8) 		4 PHE A  22
PHE A  29
PHE A  78
MET A  82
 None
 0.77A 1wrlE-1avsA:
13.2		 1wrlE-1avsA:
65.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1foe T-LYMPHOMA INVASION
AND METASTASIS
INDUCING PROTEIN 1

(Mus musculus) 		PF00169
(PH)
PF00621
(RhoGEF) 		4 PHE A1098
LEU A1048
PHE A1139
MET A1224
 None
 1.12A 1wrlE-1foeA:
undetectable		 1wrlE-1foeA:
12.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ggz CALMODULIN-RELATED
PROTEIN NB-1

(Homo sapiens) 		PF13499
(EF-hand_7) 		4 PHE A  12
PHE A  19
PHE A  68
MET A  72
 None
 0.86A 1wrlE-1ggzA:
11.3		 1wrlE-1ggzA:
57.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2t 80 KDA NUCLEAR CAP
BINDING PROTEIN

(Homo sapiens) 		PF02854
(MIF4G)
PF09088
(MIF4G_like)
PF09090
(MIF4G_like_2) 		4 PHE C 360
LEU C 402
PHE C 289
MET C 291
 None
 1.17A 1wrlE-1h2tC:
undetectable		 1wrlE-1h2tC:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
BETA SUBUNIT

(Saccharomyces
cerevisiae) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 PHE B 326
LEU B 176
SER B 440
MET B 441
 None
 1.17A 1wrlE-1hr7B:
undetectable		 1wrlE-1hr7B:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE

(Sulfolobus
acidocaldarius) 		PF00128
(Alpha-amylase)
PF09196
(DUF1953) 		4 PHE A 116
LEU A 161
PHE A 118
SER A 110
 None
None
None
MLY  A 111 ( 3.1A)
 0.99A 1wrlE-1iv8A:
undetectable		 1wrlE-1iv8A:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0h NEOPULLULANASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		4 PHE A 387
LEU A 420
PHE A 397
MET A 401
 None
 1.15A 1wrlE-1j0hA:
undetectable		 1wrlE-1j0hA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lzx NITRIC-OXIDE
SYNTHASE

(Rattus
norvegicus) 		PF02898
(NO_synthase) 		4 PHE A 427
PHE A 462
LEU A 522
SER A 585
 None
 1.04A 1wrlE-1lzxA:
undetectable		 1wrlE-1lzxA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nne DNA MISMATCH REPAIR
PROTEIN MUTS

(Thermus
aquaticus) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		4 PHE A  34
LEU A 107
PHE A  43
SER A  63
 None
 1.18A 1wrlE-1nneA:
undetectable		 1wrlE-1nneA:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nty TRIPLE FUNCTIONAL
DOMAIN PROTEIN

(Homo sapiens) 		PF00169
(PH)
PF00621
(RhoGEF) 		4 PHE A1296
LEU A1241
PHE A1321
MET A1398
 None
 0.98A 1wrlE-1ntyA:
undetectable		 1wrlE-1ntyA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogy DIHEME CYTOCHROME C
NAPB MOLECULE:
NITRATE REDUCTASE
PERIPLASMIC NITRATE
REDUCTASE

(Rhodobacter
sphaeroides) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF03892
(NapB)
PF04879
(Molybdop_Fe4S4) 		4 PHE A 715
LEU B  21
PHE A 769
SER A 772
 None
 1.03A 1wrlE-1ogyA:
undetectable		 1wrlE-1ogyA:
7.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 41 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF08542
(Rep_fac_C) 		4 PHE D 187
LEU D  82
PHE D  63
MET D  61
 None
 1.18A 1wrlE-1sxjD:
2.2		 1wrlE-1sxjD:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tu7 GLUTATHIONE
S-TRANSFERASE 2

(Onchocerca
volvulus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 PHE A 155
LEU A  76
PHE A 178
MET A 182
 None
 1.13A 1wrlE-1tu7A:
undetectable		 1wrlE-1tu7A:
16.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wrk TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES

(Homo sapiens) 		PF13833
(EF-hand_8) 		6 PHE A  20
PHE A  27
LEU A  48
PHE A  77
MET A  81
SER A  84
 TFP  A 204 ( 4.6A)
TFP  A 204 (-4.4A)
TFP  A 202 (-4.1A)
None
TFP  A 202 ( 3.3A)
TFP  A 204 (-2.9A)
 0.57A 1wrlE-1wrkA:
17.6		 1wrlE-1wrkA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wrk TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES

(Homo sapiens) 		PF13833
(EF-hand_8) 		6 PHE A  27
LEU A  48
PHE A  77
MET A  81
SER A  84
MET A  85
 TFP  A 204 (-4.4A)
TFP  A 202 (-4.1A)
None
TFP  A 202 ( 3.3A)
TFP  A 204 (-2.9A)
None
 1.15A 1wrlE-1wrkA:
17.6		 1wrlE-1wrkA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy9 ALLOGRAFT
INFLAMMATORY FACTOR
1

(Mus musculus) 		no annotation 4 PHE A  50
PHE A  57
PHE A 106
MET A 110
 None
 0.92A 1wrlE-1wy9A:
7.3		 1wrlE-1wy9A:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xpg 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Thermotoga
maritima) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		4 LEU A 488
PHE A  34
MET A  38
MET A  43
 None
 0.95A 1wrlE-1xpgA:
undetectable		 1wrlE-1xpgA:
7.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yy7 STRINGENT STARVATION
PROTEIN A

(Yersinia pestis) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 PHE A 149
LEU A 168
PHE A 143
SER A 138
 None
 1.02A 1wrlE-1yy7A:
undetectable		 1wrlE-1yy7A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b2n TRANSCRIPTION-REPAIR
COUPLING FACTOR

(Escherichia
coli) 		no annotation 4 PHE A 264
PHE A 122
LEU A  92
PHE A 265
 None
 1.03A 1wrlE-2b2nA:
undetectable		 1wrlE-2b2nA:
12.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2bl0 MYOSIN REGULATORY
LIGHT CHAIN

(Physarum
polycephalum) 		PF13833
(EF-hand_8) 		4 PHE C  20
PHE C  27
PHE C  76
MET C  80
 None
 0.42A 1wrlE-2bl0C:
9.2		 1wrlE-2bl0C:
33.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2d58 ALLOGRAFT
INFLAMMATORY FACTOR
1

(Homo sapiens) 		no annotation 4 PHE A  50
LEU A  77
PHE A 106
MET A 110
 None
 0.64A 1wrlE-2d58A:
8.5		 1wrlE-2d58A:
32.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2d58 ALLOGRAFT
INFLAMMATORY FACTOR
1

(Homo sapiens) 		no annotation 4 PHE A  57
LEU A  77
PHE A 106
MET A 110
 None
 1.17A 1wrlE-2d58A:
8.5		 1wrlE-2d58A:
32.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkh 3-HYDROXYBENZOATE
HYDROXYLASE

(Comamonas
testosteroni) 		PF01494
(FAD_binding_3)
PF07976
(Phe_hydrox_dim) 		4 PHE A 633
LEU A 621
PHE A 636
SER A 452
 None
 1.08A 1wrlE-2dkhA:
undetectable		 1wrlE-2dkhA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR

(Escherichia
coli) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02559
(CarD_CdnL_TRCF)
PF03461
(TRCF) 		4 PHE A 264
PHE A 122
LEU A  92
PHE A 265
 None
 1.03A 1wrlE-2eyqA:
undetectable		 1wrlE-2eyqA:
6.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f2p CALMODULIN FUSED
WITH
CALMODULIN-BINDING
DOMAIN OF
CALCINEURIN

(Bos taurus) 		PF13499
(EF-hand_7) 		4 PHE A  19
LEU A  39
PHE A  68
MET A  72
 None
 1.14A 1wrlE-2f2pA:
11.5		 1wrlE-2f2pA:
61.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gti REPLICASE
POLYPROTEIN 1AB

(Murine
coronavirus) 		PF06471
(NSP11) 		4 PHE A 260
PHE A 249
MET A 237
SER A 235
 None
None
None
SO4  A 506 (-4.5A)
 0.86A 1wrlE-2gtiA:
undetectable		 1wrlE-2gtiA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7c BETA-GLUCOSIDASE A

(Thermotoga
maritima) 		PF00232
(Glyco_hydro_1) 		4 PHE A 267
LEU A 176
PHE A 241
MET A 242
 None
 1.18A 1wrlE-2j7cA:
undetectable		 1wrlE-2j7cA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjz IONIZED
CALCIUM-BINDING
ADAPTER MOLECULE 2

(Homo sapiens) 		no annotation 4 PHE B  52
LEU B  79
PHE B 108
MET B 112
 None
 1.12A 1wrlE-2jjzB:
8.3		 1wrlE-2jjzB:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oba PROBABLE 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE

(Pseudomonas
aeruginosa) 		PF01242
(PTPS) 		4 PHE A  52
PHE A   7
LEU A  93
MET A   1
 None
 1.08A 1wrlE-2obaA:
undetectable		 1wrlE-2obaA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF06471
(NSP11) 		5 PHE A 232
LEU A 250
PHE A 221
MET A 209
SER A 207
 None
 1.44A 1wrlE-2ozkA:
undetectable		 1wrlE-2ozkA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q0a POTASSIUM/SODIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 2

(Mus musculus) 		PF00027
(cNMP_binding) 		4 PHE A 518
LEU A 586
PHE A 525
MET A 529
 None
 0.95A 1wrlE-2q0aA:
undetectable		 1wrlE-2q0aA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qne PUTATIVE
METHYLTRANSFERASE

(Desulfitobacterium
hafniense) 		PF06253
(MTTB) 		4 PHE A  40
LEU A 214
PHE A  58
SER A  65
 None
None
EDO  A 481 (-4.8A)
None
 1.07A 1wrlE-2qneA:
undetectable		 1wrlE-2qneA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		4 PHE A 498
PHE A 739
LEU A 586
PHE A 499
 None
 1.06A 1wrlE-2vdcA:
undetectable		 1wrlE-2vdcA:
4.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2w49 TROPONIN C, SKELETAL
MUSCLE

(Gallus gallus) 		PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		5 PHE 0  21
PHE 0  28
LEU 0  48
PHE 0  77
MET 0  81
 None
 0.98A 1wrlE-2w490:
13.0		 1wrlE-2w490:
64.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3a PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT BETA ISOFORM

(Mus musculus) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B) 		4 PHE A1039
LEU A 927
PHE A 952
SER A1046
 None
 1.15A 1wrlE-2y3aA:
undetectable		 1wrlE-2y3aA:
7.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2

(Saccharomyces
cerevisiae) 		PF04072
(LCM)
PF13418
(Kelch_4) 		4 PHE A 339
LEU A 253
PHE A 336
SER A 315
 None
 1.19A 1wrlE-2zwaA:
undetectable		 1wrlE-2zwaA:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afb PUTATIVE CHITINASE

(Pyrococcus
furiosus) 		no annotation 4 PHE A 523
LEU A 505
PHE A 552
MET A 572
 None
 1.08A 1wrlE-3afbA:
undetectable		 1wrlE-3afbA:
13.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b32 CALMODULIN

(Rattus
norvegicus) 		PF13499
(EF-hand_7) 		4 PHE A  19
LEU A  39
PHE A  68
MET A  72
 None
 1.15A 1wrlE-3b32A:
11.2		 1wrlE-3b32A:
59.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8) 		4 PHE A 270
LEU A 287
PHE A 205
MET A 201
 None
 1.09A 1wrlE-3gcwA:
undetectable		 1wrlE-3gcwA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gpu DNA GLYCOSYLASE

(Geobacillus
stearothermophilus) 		PF01149
(Fapy_DNA_glyco)
PF06827
(zf-FPG_IleRS)
PF06831
(H2TH) 		4 PHE A 172
LEU A 195
PHE A 143
MET A 207
 None
 1.02A 1wrlE-3gpuA:
undetectable		 1wrlE-3gpuA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjh TRANSCRIPTION-REPAIR
-COUPLING FACTOR

(Escherichia
coli) 		no annotation 4 PHE A 264
PHE A 122
LEU A  92
PHE A 265
 None
 0.96A 1wrlE-3hjhA:
undetectable		 1wrlE-3hjhA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3v PROBABLE SECRETED
SOLUTE-BINDING
LIPOPROTEIN

(Streptomyces
coelicolor) 		PF01547
(SBP_bac_1) 		4 PHE A 322
LEU A  59
PHE A 338
MET A 342
 None
 0.99A 1wrlE-3i3vA:
undetectable		 1wrlE-3i3vA:
13.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ifk CALMODULIN

(Rattus
norvegicus) 		PF13499
(EF-hand_7) 		4 PHE A  12
PHE A  19
PHE A  68
MET A  72
 None
 0.89A 1wrlE-3ifkA:
10.3		 1wrlE-3ifkA:
60.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jxf RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE ZETA

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 PHE A 128
LEU A 220
PHE A 263
SER A 256
 None
 0.97A 1wrlE-3jxfA:
undetectable		 1wrlE-3jxfA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4h E3 UBIQUITIN-PROTEIN
LIGASE HECW1

(Homo sapiens) 		PF00397
(WW) 		4 PHE A 977
PHE A1013
LEU A1053
PHE A1009
 None
 0.89A 1wrlE-3l4hA:
undetectable		 1wrlE-3l4hA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m5u PHOSPHOSERINE
AMINOTRANSFERASE

(Campylobacter
jejuni) 		PF00266
(Aminotran_5) 		4 PHE A 173
LEU A  62
PHE A 243
SER A 230
 None
 1.19A 1wrlE-3m5uA:
undetectable		 1wrlE-3m5uA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pj9 NUCLEOSIDE
DIPHOSPHATE KINASE

(Campylobacter
jejuni) 		PF00334
(NDK) 		4 PHE A 130
LEU A  22
PHE A 131
SER A 117
 SO4  A 139 ( 4.9A)
None
SO4  A 141 (-4.9A)
None
 1.16A 1wrlE-3pj9A:
undetectable		 1wrlE-3pj9A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pua PHD FINGER PROTEIN 2

(Homo sapiens) 		PF02373
(JmjC) 		4 PHE A 366
PHE A 406
LEU A 377
MET A 346
 None
 1.18A 1wrlE-3puaA:
undetectable		 1wrlE-3puaA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0k RCAMP

(Entacmaea
quadricolor) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		5 PHE A 306
PHE A 313
LEU A 333
PHE A 362
MET A 366
 None
 1.16A 1wrlE-3u0kA:
10.3		 1wrlE-3u0kA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 PHE A3763
PHE A3786
LEU A3652
PHE A3765
 None
 1.12A 1wrlE-3vkgA:
undetectable		 1wrlE-3vkgA:
2.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5n PUTATIVE
RHAMNOSIDASE

(Streptomyces
avermitilis) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		4 LEU A 625
PHE A 598
MET A 655
SER A 657
 None
RAM  A1204 (-3.6A)
None
None
 0.87A 1wrlE-3w5nA:
undetectable		 1wrlE-3w5nA:
7.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4buc UDP-N-ACETYLMURAMOYL
ALANINE--D-GLUTAMATE
LIGASE

(Thermotoga
maritima) 		PF08245
(Mur_ligase_M) 		4 PHE A 442
PHE A 403
MET A 407
SER A 410
 None
None
PO4  A1005 (-4.5A)
None
 0.93A 1wrlE-4bucA:
undetectable		 1wrlE-4bucA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ekd GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(Q) SUBUNIT
ALPHA

(Mus musculus) 		PF00503
(G-alpha) 		4 PHE A 272
LEU A 196
MET A 227
SER A 225
 None
 0.99A 1wrlE-4ekdA:
undetectable		 1wrlE-4ekdA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ezi UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 4 PHE A 265
PHE A 306
LEU A 321
PHE A 269
 None
 1.19A 1wrlE-4eziA:
undetectable		 1wrlE-4eziA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fcg UNCHARACTERIZED
PROTEIN

(Xanthomonas
euvesicatoria) 		PF13855
(LRR_8) 		4 LEU A 261
PHE A 248
MET A 245
SER A 267
 None
 1.15A 1wrlE-4fcgA:
undetectable		 1wrlE-4fcgA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)

(Chaetomium
thermophilum) 		PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C) 		4 PHE A 331
PHE A 316
PHE A 273
SER A 281
 None
 1.07A 1wrlE-4fgvA:
undetectable		 1wrlE-4fgvA:
5.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4flc ADENYLOSUCCINATE
LYASE

(Homo sapiens) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		4 LEU A 311
PHE A  30
MET A  26
SER A  23
 None
 0.78A 1wrlE-4flcA:
undetectable		 1wrlE-4flcA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gf0 GLUTATHIONE
S-TRANSFERASE

(Sulfitobacter
sp. NAS-14.1) 		PF02798
(GST_N)
PF13410
(GST_C_2) 		4 PHE A 166
LEU A  83
PHE A 188
MET A 192
 None
 1.04A 1wrlE-4gf0A:
undetectable		 1wrlE-4gf0A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gyt UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		PF03695
(UPF0149) 		4 PHE A  75
PHE A  16
LEU A  25
MET A  36
 None
 1.19A 1wrlE-4gytA:
undetectable		 1wrlE-4gytA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i2y RGECO1

(Discosoma sp.;
Gallus gallus;
Rattus
norvegicus) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		4 PHE A 315
PHE A 322
PHE A 371
MET A 375
 None
 0.82A 1wrlE-4i2yA:
10.7		 1wrlE-4i2yA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3f SERINE HYDROLASE
CCSP0084

(Cycloclasticus
sp. P1) 		PF12697
(Abhydrolase_6) 		4 PHE A 193
LEU A 158
PHE A  63
SER A  40
 None
 1.11A 1wrlE-4i3fA:
undetectable		 1wrlE-4i3fA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iik ADENOSINE
MONOPHOSPHATE-PROTEI
N HYDROLASE SIDD

(Legionella
pneumophila) 		no annotation 4 PHE A 123
LEU A 131
PHE A 169
MET A 171
 None
 1.14A 1wrlE-4iikA:
undetectable		 1wrlE-4iikA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jra SYNAPTIC VESICLE
GLYCOPROTEIN 2C

(Homo sapiens) 		PF13599
(Pentapeptide_4) 		4 PHE C 542
PHE C 507
PHE C 547
SER C 555
 None
 0.90A 1wrlE-4jraC:
undetectable		 1wrlE-4jraC:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf7 NUP188

(Thermothelomyces
thermophila) 		PF10487
(Nup188) 		4 PHE A 604
LEU A 721
PHE A 600
SER A 712
 None
 1.03A 1wrlE-4kf7A:
undetectable		 1wrlE-4kf7A:
5.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4knh NUP192P

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		4 PHE A 165
PHE A  42
LEU A  17
SER A 244
 None
 1.07A 1wrlE-4knhA:
undetectable		 1wrlE-4knhA:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2

(Haemonchus
contortus) 		PF08241
(Methyltransf_11) 		4 PHE A 155
PHE A 136
MET A 113
MET A 110
 None
 1.02A 1wrlE-4kriA:
undetectable		 1wrlE-4kriA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ntq ECL CDII

(Enterobacter
cloacae) 		no annotation 4 PHE B   2
LEU B  34
PHE B 139
SER B  51
 None
 1.19A 1wrlE-4ntqB:
undetectable		 1wrlE-4ntqB:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 CALCIUM-BINDING
PROTEIN 39

(Homo sapiens) 		PF08569
(Mo25) 		4 PHE A 169
PHE A 210
LEU A 236
PHE A 166
 None
 1.10A 1wrlE-4o27A:
undetectable		 1wrlE-4o27A:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pag PERIPLASMIC BINDING
PROTEIN

(Sulfurospirillum
deleyianum) 		PF01497
(Peripla_BP_2) 		4 PHE A 320
PHE A 338
MET A 292
SER A 290
 None
 1.08A 1wrlE-4pagA:
undetectable		 1wrlE-4pagA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pju COHESIN SUBUNIT SA-2

(Homo sapiens) 		PF08514
(STAG) 		4 PHE A 367
LEU A 393
MET A 316
MET A 318
 None
 1.18A 1wrlE-4pjuA:
undetectable		 1wrlE-4pjuA:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ufs LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5

(Homo sapiens) 		PF00560
(LRR_1)
PF01462
(LRRNT)
PF13855
(LRR_8) 		4 PHE A 249
PHE A 288
LEU A 307
PHE A 264
 None
 1.15A 1wrlE-4ufsA:
undetectable		 1wrlE-4ufsA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3h PROTEIN SCARECROW

(Arabidopsis
thaliana) 		PF03514
(GRAS) 		4 PHE A 370
LEU A 524
PHE A 373
SER A 383
 None
 1.18A 1wrlE-5b3hA:
undetectable		 1wrlE-5b3hA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ck0 SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 PHE A 381
PHE A 561
PHE A 384
MET A 431
 None
 1.15A 1wrlE-5ck0A:
undetectable		 1wrlE-5ck0A:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5evh UNCHARACTERIZED
PROTEIN

(Kribbella
flavida) 		PF12680
(SnoaL_2) 		4 PHE A  57
PHE A  50
LEU A  96
PHE A  53
 GOL  A 201 ( 3.8A)
None
None
GOL  A 201 ( 4.8A)
 0.96A 1wrlE-5evhA:
undetectable		 1wrlE-5evhA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyt ADENYLOSUCCINATE
LYASE

(Schistosoma
mansoni) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		4 LEU A 306
PHE A  24
MET A  20
SER A  17
 None
 0.69A 1wrlE-5eytA:
undetectable		 1wrlE-5eytA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE

(Thermotoga
neapolitana) 		PF00232
(Glyco_hydro_1) 		4 PHE A 265
LEU A 174
PHE A 239
MET A 240
 None
 1.04A 1wrlE-5idiA:
undetectable		 1wrlE-5idiA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jlv SYNAPTIC VESICLE
GLYCOPROTEIN 2C

(Homo sapiens) 		PF13599
(Pentapeptide_4) 		4 PHE C 542
PHE C 507
PHE C 547
SER C 555
 None
 1.08A 1wrlE-5jlvC:
undetectable		 1wrlE-5jlvC:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kxb WISTERIA FLORIBUNDA
AGGLUTININ

(Wisteria
floribunda) 		PF00139
(Lectin_legB) 		4 PHE A 121
PHE A 156
LEU A 221
PHE A 103
 None
 1.00A 1wrlE-5kxbA:
undetectable		 1wrlE-5kxbA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
11, MITOCHONDRIAL
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4

(Bos taurus) 		PF00361
(Proton_antipo_M)
PF01059
(Oxidored_q5_N)
PF10588
(NADH-G_4Fe-4S_3)
PF13510
(Fer2_4) 		4 PHE g  62
LEU M  11
MET M  78
SER M  80
 None
 1.05A 1wrlE-5lc5g:
undetectable		 1wrlE-5lc5g:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lnb UBIQUITIN-LIKE-SPECI
FIC PROTEASE 2

(Saccharomyces
cerevisiae) 		PF02902
(Peptidase_C48) 		4 PHE B 185
LEU B 135
PHE B  87
MET B  83
 None
 1.06A 1wrlE-5lnbB:
undetectable		 1wrlE-5lnbB:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mtv EH DOMAIN-CONTAINING
PROTEIN 4

(Mus musculus) 		PF00350
(Dynamin_N)
PF16880
(EHD_N) 		4 PHE A 131
PHE A 100
LEU A  65
PHE A 135
 None
 1.18A 1wrlE-5mtvA:
undetectable		 1wrlE-5mtvA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1) 		no annotation 4 PHE A 400
PHE A 193
MET A 201
SER A 204
 None
 0.89A 1wrlE-5nd1A:
undetectable		 1wrlE-5nd1A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nf4 MINOR FIMBRIUM TIP
SUBUNIT MFA3

(Porphyromonas
gingivalis) 		no annotation 4 PHE A 108
LEU A 101
PHE A 110
SER A  85
 None
 1.18A 1wrlE-5nf4A:
undetectable		 1wrlE-5nf4A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o33 KALIRIN

(Rattus
norvegicus) 		PF00621
(RhoGEF) 		4 PHE B1296
LEU B1241
PHE B1321
MET B1398
 None
 0.97A 1wrlE-5o33B:
undetectable		 1wrlE-5o33B:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT) 		4 PHE T3641
PHE T3548
LEU T3467
SER T3559
 None
 0.70A 1wrlE-5ojsT:
undetectable		 1wrlE-5ojsT:
2.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t88 PROLYL ENDOPEPTIDASE

(Pyrococcus
furiosus) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		4 PHE A 399
PHE A 413
MET A 411
SER A 324
 None
 1.00A 1wrlE-5t88A:
undetectable		 1wrlE-5t88A:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v2d DIOXYGENASE

(Pseudomonas
brassicacearum) 		no annotation 4 LEU A 148
PHE A 468
MET A 470
MET A 472
 None
 1.11A 1wrlE-5v2dA:
undetectable		 1wrlE-5v2dA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v4l ADENYLOSUCCINATE
LYASE

(Cryptococcus
neoformans) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		4 LEU A 248
PHE A  21
MET A  17
SER A  14
 None
 1.11A 1wrlE-5v4lA:
undetectable		 1wrlE-5v4lA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v4l ADENYLOSUCCINATE
LYASE

(Cryptococcus
neoformans) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		4 LEU A 304
PHE A  21
MET A  17
SER A  14
 None
 0.75A 1wrlE-5v4lA:
undetectable		 1wrlE-5v4lA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vwm UDP-3-O-ACYL-N-ACETY
LGLUCOSAMINE
DEACETYLASE

(Pseudomonas
aeruginosa) 		PF03331
(LpxC) 		4 PHE A 110
LEU A  95
SER A  63
MET A  62
 None
None
EDO  A 406 (-2.8A)
C90  A 401 ( 4.5A)
 1.16A 1wrlE-5vwmA:
undetectable		 1wrlE-5vwmA:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7d ACYLOXYACYL
HYDROLASE

(Mus musculus) 		no annotation 4 PHE A 528
PHE A 446
LEU A  41
SER A 377
 PX8  A 610 (-4.9A)
PX8  A 610 ( 4.2A)
PX8  A 610 ( 4.5A)
None
 1.15A 1wrlE-5w7dA:
undetectable		 1wrlE-5w7dA:
17.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w88 TROPONIN C, TROPONIN
I

(Homo sapiens) 		PF00992
(Troponin)
PF13833
(EF-hand_8) 		5 PHE A  20
PHE A  27
LEU A  48
PHE A  77
MET A  81
 None
9XG  A 201 (-3.8A)
9XG  A 201 ( 4.8A)
9XG  A 201 (-3.8A)
9XG  A 201 ( 4.6A)
 1.26A 1wrlE-5w88A:
11.8		 1wrlE-5w88A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w88 TROPONIN C, TROPONIN
I

(Homo sapiens) 		PF00992
(Troponin)
PF13833
(EF-hand_8) 		4 PHE A  20
PHE A  77
MET A  81
SER A  84
 None
9XG  A 201 (-3.8A)
9XG  A 201 ( 4.6A)
9XG  A 201 ( 4.3A)
 1.01A 1wrlE-5w88A:
11.8		 1wrlE-5w88A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y5a KLLA0F20702P

(Kluyveromyces
lactis) 		no annotation 4 PHE A 434
PHE A 427
PHE A 430
MET A 314
 None
 1.11A 1wrlE-5y5aA:
undetectable		 1wrlE-5y5aA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dfz GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Acropora
millepora) 		no annotation 4 PHE A  45
PHE A   9
MET A  17
SER A  20
 None
 1.18A 1wrlE-6dfzA:
undetectable		 1wrlE-6dfzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6es1 SYNAPTIC VESICLE
GLYCOPROTEIN 2C

(Homo sapiens) 		no annotation 4 PHE B 542
PHE B 507
PHE B 547
SER B 555
 None
 1.14A 1wrlE-6es1B:
undetectable		 1wrlE-6es1B:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f4f GLUTATHIONE
TRANSFERASE

(Trametes
versicolor) 		no annotation 4 PHE A 173
PHE A 123
LEU A 143
MET A 195
 None
 1.11A 1wrlE-6f4fA:
undetectable		 1wrlE-6f4fA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fj4 ENDO-1,4-BETA-XYLANA
SE Y

(Ruminiclostridium
thermocellum) 		no annotation 4 PHE A1011
PHE A 860
LEU A 880
PHE A1074
 None
 1.17A 1wrlE-6fj4A:
undetectable		 1wrlE-6fj4A:
21.59