SIMILAR PATTERNS OF AMINO ACIDS FOR 1WRL_D_TFPD207_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a6c TOBACCO RINGSPOT
VIRUS CAPSID PROTEIN

(Tobacco
ringspot virus) 		PF03391
(Nepo_coat)
PF03688
(Nepo_coat_C)
PF03689
(Nepo_coat_N) 		4 PHE A  31
PHE A  78
LEU A 128
MET A 162
 None
 0.99A 1wrlC-1a6cA:
undetectable
1wrlD-1a6cA:
undetectable		 1wrlC-1a6cA:
12.56
1wrlD-1a6cA:
12.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1aj4 TROPONIN C

(Gallus gallus) 		PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		5 LEU A  12
PHE A  20
PHE A  77
MET A  81
SER A  84
 None
 1.29A 1wrlC-1aj4A:
9.6
1wrlD-1aj4A:
9.4		 1wrlC-1aj4A:
97.73
1wrlD-1aj4A:
97.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1avs TROPONIN C

(Gallus gallus) 		PF13833
(EF-hand_8) 		5 LEU A  14
PHE A  22
PHE A  29
PHE A  78
MET A  82
 None
 0.89A 1wrlC-1avsA:
13.1
1wrlD-1avsA:
12.9		 1wrlC-1avsA:
65.91
1wrlD-1avsA:
65.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b5l INTERFERON TAU

(Komagataella
pastoris) 		PF00143
(Interferon) 		4 LEU A  82
PHE A  68
PHE A 124
LEU A  38
 None
 0.99A 1wrlC-1b5lA:
undetectable
1wrlD-1b5lA:
undetectable		 1wrlC-1b5lA:
20.24
1wrlD-1b5lA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b8a PROTEIN
(ASPARTYL-TRNA
SYNTHETASE)

(Thermococcus
kodakarensis) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 LEU A 375
PHE A 338
LEU A 175
SER A 388
 None
 1.03A 1wrlC-1b8aA:
undetectable
1wrlD-1b8aA:
undetectable		 1wrlC-1b8aA:
13.33
1wrlD-1b8aA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB

(Thermus
thermophilus) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF12344
(UvrB) 		4 SER A 399
LEU A  21
LEU A 342
SER A 388
 None
 0.85A 1wrlC-1c4oA:
undetectable
1wrlD-1c4oA:
undetectable		 1wrlC-1c4oA:
8.58
1wrlD-1c4oA:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cj2 PROTEIN
(P-HYDROXYBENZOATE
HYDROXYLASE)

(Pseudomonas
fluorescens) 		PF01494
(FAD_binding_3) 		4 LEU A 372
PHE A 342
MET A 346
SER A 348
 None
 1.00A 1wrlC-1cj2A:
undetectable
1wrlD-1cj2A:
undetectable		 1wrlC-1cj2A:
12.36
1wrlD-1cj2A:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dih DIHYDRODIPICOLINATE
REDUCTASE

(Escherichia
coli) 		PF01113
(DapB_N)
PF05173
(DapB_C) 		4 SER A 250
LEU A  21
PHE A  79
SER A 130
 None
None
NDP  A 301 (-4.7A)
None
 0.98A 1wrlC-1dihA:
undetectable
1wrlD-1dihA:
undetectable		 1wrlC-1dihA:
16.73
1wrlD-1dihA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f3u TRANSCRIPTION
INITIATION FACTOR
IIF, ALPHA SUBUNIT
TRANSCRIPTION
INITIATION FACTOR
IIF, BETA SUBUNIT

(Homo sapiens) 		PF02270
(TFIIF_beta)
PF05793
(TFIIF_alpha) 		4 PHE B 146
LEU A   9
PHE B  31
MET B  29
 None
 0.70A 1wrlC-1f3uB:
undetectable
1wrlD-1f3uB:
undetectable		 1wrlC-1f3uB:
18.02
1wrlD-1f3uB:
18.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ggz CALMODULIN-RELATED
PROTEIN NB-1

(Homo sapiens) 		PF13499
(EF-hand_7) 		5 LEU A   4
PHE A  12
PHE A  19
PHE A  68
MET A  72
 None
 0.98A 1wrlC-1ggzA:
11.2
1wrlD-1ggzA:
11.2		 1wrlC-1ggzA:
57.30
1wrlD-1ggzA:
57.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hcu ALPHA-1,2-MANNOSIDAS
E

(Trichoderma
reesei) 		PF01532
(Glyco_hydro_47) 		4 SER A 246
LEU A 208
LEU A 106
PHE A 148
 None
 0.97A 1wrlC-1hcuA:
undetectable
1wrlD-1hcuA:
undetectable		 1wrlC-1hcuA:
9.64
1wrlD-1hcuA:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i9z PHOSPHATIDYLINOSITOL
PHOSPHATE
PHOSPHATASE

(Schizosaccharomyces
pombe) 		PF03372
(Exo_endo_phos) 		4 LEU A 770
PHE A 780
PHE A 730
PHE A 783
 None
 0.90A 1wrlC-1i9zA:
undetectable
1wrlD-1i9zA:
undetectable		 1wrlC-1i9zA:
12.28
1wrlD-1i9zA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l0w ASPARTYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		4 SER A 481
LEU A 428
LEU A 202
PHE A 494
 None
 1.00A 1wrlC-1l0wA:
undetectable
1wrlD-1l0wA:
undetectable		 1wrlC-1l0wA:
8.98
1wrlD-1l0wA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l2q MONOMETHYLAMINE
METHYLTRANSFERASE

(Methanosarcina
barkeri) 		PF05369
(MtmB) 		4 LEU A  70
PHE A  12
MET A 288
SER A 290
 None
 0.97A 1wrlC-1l2qA:
undetectable
1wrlD-1l2qA:
undetectable		 1wrlC-1l2qA:
11.67
1wrlD-1l2qA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lkj CALMODULIN

(Saccharomyces
cerevisiae) 		PF13499
(EF-hand_7) 		4 LEU A   4
PHE A  12
PHE A  68
MET A  72
 None
 0.60A 1wrlC-1lkjA:
5.3
1wrlD-1lkjA:
5.6		 1wrlC-1lkjA:
28.03
1wrlD-1lkjA:
28.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m4x PBCV-1 VIRUS CAPSID

(Paramecium
bursaria
Chlorella virus
1) 		PF04451
(Capsid_NCLDV)
PF16903
(Capsid_N) 		4 LEU A 320
PHE A 371
LEU A 231
SER A 355
 None
 0.97A 1wrlC-1m4xA:
undetectable
1wrlD-1m4xA:
undetectable		 1wrlC-1m4xA:
11.33
1wrlD-1m4xA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhs PLASMA MEMBRANE
ATPASE

(Neurospora
crassa) 		PF00122
(E1-E2_ATPase)
PF00690
(Cation_ATPase_N)
PF00702
(Hydrolase) 		4 LEU A 702
PHE A 841
PHE A 798
SER A 716
 None
 1.01A 1wrlC-1mhsA:
undetectable
1wrlD-1mhsA:
undetectable		 1wrlC-1mhsA:
7.42
1wrlD-1mhsA:
7.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nty TRIPLE FUNCTIONAL
DOMAIN PROTEIN

(Homo sapiens) 		PF00169
(PH)
PF00621
(RhoGEF) 		4 PHE A1296
LEU A1241
PHE A1321
MET A1398
 None
 0.96A 1wrlC-1ntyA:
undetectable
1wrlD-1ntyA:
undetectable		 1wrlC-1ntyA:
17.19
1wrlD-1ntyA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o4s ASPARTATE
AMINOTRANSFERASE

(Thermotoga
maritima) 		PF00155
(Aminotran_1_2) 		4 LEU A 301
PHE A 319
LEU A  17
SER A 355
 None
 0.98A 1wrlC-1o4sA:
undetectable
1wrlD-1o4sA:
undetectable		 1wrlC-1o4sA:
15.73
1wrlD-1o4sA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		4 LEU A 834
PHE A 870
LEU A1193
PHE A1127
 None
 1.02A 1wrlC-1ofeA:
undetectable
1wrlD-1ofeA:
undetectable		 1wrlC-1ofeA:
4.92
1wrlD-1ofeA:
4.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1a HST2 PROTEIN

(Saccharomyces
cerevisiae) 		PF02146
(SIR2) 		4 PHE A  67
LEU A 159
PHE A 183
SER A 137
 OAD  A1001 ( 4.6A)
None
None
None
 1.02A 1wrlC-1q1aA:
undetectable
1wrlD-1q1aA:
undetectable		 1wrlC-1q1aA:
15.11
1wrlD-1q1aA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qs8 PLASMEPSIN

(Plasmodium
vivax) 		PF00026
(Asp) 		4 LEU A   8
PHE A 156
LEU A 131
PHE A 154
 None
 0.99A 1wrlC-1qs8A:
undetectable
1wrlD-1qs8A:
undetectable		 1wrlC-1qs8A:
13.99
1wrlD-1qs8A:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ral 3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE

(Rattus
norvegicus) 		PF00248
(Aldo_ket_red) 		4 SER A 166
LEU A 268
PHE A  80
SER A  83
 None
 1.00A 1wrlC-1ralA:
undetectable
1wrlD-1ralA:
undetectable		 1wrlC-1ralA:
15.82
1wrlD-1ralA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s1g POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY D
MEMBER 3

(Homo sapiens) 		PF02214
(BTB_2) 		4 LEU A  44
PHE A  84
PHE A 120
SER A  68
 None
 0.98A 1wrlC-1s1gA:
undetectable
1wrlD-1s1gA:
undetectable		 1wrlC-1s1gA:
18.55
1wrlD-1s1gA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tl7 ADENYLATE CYCLASE,
TYPE V

(Canis lupus) 		PF00211
(Guanylate_cyc) 		4 SER A 508
PHE A 394
LEU A 554
SER A 489
 None
FOK  A 101 (-4.9A)
None
None
 1.03A 1wrlC-1tl7A:
undetectable
1wrlD-1tl7A:
undetectable		 1wrlC-1tl7A:
18.26
1wrlD-1tl7A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v8p HYPOTHETICAL PROTEIN
PAE2754

(Pyrobaculum
aerophilum) 		PF01850
(PIN) 		4 LEU A  61
LEU A 127
PHE A  68
SER A  10
 None
 1.01A 1wrlC-1v8pA:
undetectable
1wrlD-1v8pA:
undetectable		 1wrlC-1v8pA:
24.32
1wrlD-1v8pA:
24.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wrk TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES

(Homo sapiens) 		PF13833
(EF-hand_8) 		6 LEU A  12
PHE A  20
PHE A  27
LEU A  48
PHE A  77
MET A  81
 None
TFP  A 204 ( 4.6A)
TFP  A 204 (-4.4A)
TFP  A 202 (-4.1A)
None
TFP  A 202 ( 3.3A)
 0.27A 1wrlC-1wrkA:
17.3
1wrlD-1wrkA:
17.0		 1wrlC-1wrkA:
100.00
1wrlD-1wrkA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy9 ALLOGRAFT
INFLAMMATORY FACTOR
1

(Mus musculus) 		no annotation 4 PHE A  50
PHE A  57
PHE A 106
MET A 110
 None
 0.91A 1wrlC-1wy9A:
7.3
1wrlD-1wy9A:
7.1		 1wrlC-1wy9A:
25.34
1wrlD-1wy9A:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xsz GUANINE NUCLEOTIDE
EXCHANGE PROTEIN

(Legionella
pneumophila) 		PF01369
(Sec7) 		4 LEU A 183
PHE A 255
LEU A 100
SER A 115
 None
 0.89A 1wrlC-1xszA:
undetectable
1wrlD-1xszA:
undetectable		 1wrlC-1xszA:
12.11
1wrlD-1xszA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xuv HYPOTHETICAL PROTEIN
MM0500

(Methanosarcina
mazei) 		PF08327
(AHSA1) 		4 SER A 157
LEU A 130
PHE A  41
LEU A  60
 None
 0.80A 1wrlC-1xuvA:
undetectable
1wrlD-1xuvA:
undetectable		 1wrlC-1xuvA:
23.39
1wrlD-1xuvA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y82 HYPOTHETICAL PROTEIN

(Pyrococcus
furiosus) 		PF01850
(PIN) 		4 LEU A  63
PHE A 136
PHE A   9
SER A  19
 None
 0.97A 1wrlC-1y82A:
undetectable
1wrlD-1y82A:
undetectable		 1wrlC-1y82A:
17.90
1wrlD-1y82A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yaa ASPARTATE
AMINOTRANSFERASE

(Saccharomyces
cerevisiae) 		PF00155
(Aminotran_1_2) 		4 PHE A 122
LEU A 270
PHE A 123
SER A 115
 None
 0.92A 1wrlC-1yaaA:
undetectable
1wrlD-1yaaA:
undetectable		 1wrlC-1yaaA:
12.35
1wrlD-1yaaA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yhu HEMOGLOBIN B2 CHAIN

(Riftia
pachyptila) 		PF00042
(Globin) 		4 LEU D 147
PHE D 109
PHE D 136
MET D 143
 None
HEM  D 160 (-3.5A)
None
HEM  D 160 (-3.5A)
 1.00A 1wrlC-1yhuD:
undetectable
1wrlD-1yhuD:
undetectable		 1wrlC-1yhuD:
18.67
1wrlD-1yhuD:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yrg GTPASE-ACTIVATING
PROTEIN RNA1_SCHPO

(Schizosaccharomyces
pombe) 		no annotation 4 LEU A 276
PHE A 228
LEU A 207
SER A 242
 None
 1.01A 1wrlC-1yrgA:
undetectable
1wrlD-1yrgA:
undetectable		 1wrlC-1yrgA:
12.87
1wrlD-1yrgA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yvp 60-KDA SS-A/RO
RIBONUCLEOPROTEIN

(Xenopus laevis) 		PF05731
(TROVE) 		4 SER A 360
LEU A 527
LEU A 386
MET A 399
 None
 0.96A 1wrlC-1yvpA:
undetectable
1wrlD-1yvpA:
undetectable		 1wrlC-1yvpA:
9.75
1wrlD-1yvpA:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9n SUPEROXIDE DISMUTASE
[CU-ZN]

([Haemophilus]
ducreyi) 		PF00080
(Sod_Cu) 		4 LEU A 137
PHE A  55
PHE A  69
SER A 147
 None
 1.02A 1wrlC-1z9nA:
undetectable
1wrlD-1z9nA:
undetectable		 1wrlC-1z9nA:
19.02
1wrlD-1z9nA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9p SUPEROXIDE DISMUTASE
[CU-ZN]

([Haemophilus]
ducreyi) 		PF00080
(Sod_Cu) 		4 LEU A 137
PHE A  55
PHE A  69
SER A 147
 None
 1.00A 1wrlC-1z9pA:
undetectable
1wrlD-1z9pA:
undetectable		 1wrlC-1z9pA:
18.83
1wrlD-1z9pA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ztv HYPOTHETICAL PROTEIN

(Enterococcus
faecalis) 		PF01904
(DUF72) 		5 SER A  99
LEU A 133
PHE A 105
PHE A  89
MET A  93
 None
 1.40A 1wrlC-1ztvA:
undetectable
1wrlD-1ztvA:
undetectable		 1wrlC-1ztvA:
16.03
1wrlD-1ztvA:
16.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ami CALTRACTIN

(Chlamydomonas
reinhardtii) 		PF13499
(EF-hand_7) 		4 LEU A   4
PHE A  19
PHE A  68
MET A  72
 None
 0.77A 1wrlC-2amiA:
9.9
1wrlD-2amiA:
10.3		 1wrlC-2amiA:
47.47
1wrlD-2amiA:
47.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2anl PLASMEPSIN IV

(Plasmodium
malariae) 		PF00026
(Asp) 		4 LEU A   8
PHE A 156
LEU A 131
PHE A 154
 None
None
JE2  A3151 (-4.9A)
None
 0.99A 1wrlC-2anlA:
undetectable
1wrlD-2anlA:
undetectable		 1wrlC-2anlA:
15.19
1wrlD-2anlA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aps PROTEIN (CU,ZN
SUPEROXIDE
DISMUTASE)

(Actinobacillus
pleuropneumoniae) 		PF00080
(Sod_Cu) 		4 LEU A 127
PHE A  45
PHE A  59
SER A 137
 None
 1.04A 1wrlC-2apsA:
undetectable
1wrlD-2apsA:
undetectable		 1wrlC-2apsA:
19.50
1wrlD-2apsA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aqt SUPEROXIDE DISMUTASE
[CU-ZN]

(Neisseria
meningitidis) 		no annotation 4 LEU C 146
PHE C  64
PHE C  78
SER C 156
 None
 1.00A 1wrlC-2aqtC:
undetectable
1wrlD-2aqtC:
undetectable		 1wrlC-2aqtC:
20.67
1wrlD-2aqtC:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bap DIAPHANOUS PROTEIN
HOMOLOG 1

(Mus musculus) 		no annotation 4 LEU B 159
PHE B 174
PHE B 220
PHE B 215
 None
 1.04A 1wrlC-2bapB:
undetectable
1wrlD-2bapB:
undetectable		 1wrlC-2bapB:
15.87
1wrlD-2bapB:
15.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2bl0 MYOSIN REGULATORY
LIGHT CHAIN

(Physarum
polycephalum) 		PF13833
(EF-hand_8) 		4 PHE C  20
PHE C  27
PHE C  76
MET C  80
 None
 0.50A 1wrlC-2bl0C:
9.1
1wrlD-2bl0C:
9.2		 1wrlC-2bl0C:
33.98
1wrlD-2bl0C:
33.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cwo RNA SILENCING
SUPPRESSOR

(Beet yellows
virus) 		PF11479
(Suppressor_P21) 		4 LEU A 137
PHE A 109
LEU A 173
SER A 154
 None
 0.84A 1wrlC-2cwoA:
undetectable
1wrlD-2cwoA:
undetectable		 1wrlC-2cwoA:
17.10
1wrlD-2cwoA:
17.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2d58 ALLOGRAFT
INFLAMMATORY FACTOR
1

(Homo sapiens) 		no annotation 4 PHE A  50
LEU A  77
PHE A 106
MET A 110
 None
 0.79A 1wrlC-2d58A:
8.6
1wrlD-2d58A:
8.5		 1wrlC-2d58A:
32.46
1wrlD-2d58A:
32.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2efj 3,7-DIMETHYLXANTHINE
METHYLTRANSFERASE

(Coffea
canephora) 		PF03492
(Methyltransf_7) 		4 LEU A  28
PHE A 140
LEU A   7
SER A  63
 SAH  A 501 ( 4.8A)
SAH  A 501 (-3.5A)
SAH  A 501 (-4.8A)
None
 0.81A 1wrlC-2efjA:
undetectable
1wrlD-2efjA:
undetectable		 1wrlC-2efjA:
13.28
1wrlD-2efjA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eia EIAV CAPSID PROTEIN
P26

(Equine
infectious
anemia virus) 		PF00607
(Gag_p24) 		4 SER A 182
LEU A 211
PHE A 164
SER A 170
 None
 1.03A 1wrlC-2eiaA:
undetectable
1wrlD-2eiaA:
undetectable		 1wrlC-2eiaA:
17.10
1wrlD-2eiaA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ex3 DNA TERMINAL PROTEIN

(Bacillus virus
phi29) 		PF05435
(Phi-29_GP3) 		4 SER B 189
LEU B 182
PHE B 215
LEU B 248
 None
 0.89A 1wrlC-2ex3B:
undetectable
1wrlD-2ex3B:
undetectable		 1wrlC-2ex3B:
19.07
1wrlD-2ex3B:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f3j RNA AND EXPORT
FACTOR BINDING
PROTEIN 2

(Mus musculus) 		PF00076
(RRM_1)
PF07078
(FYTT) 		4 PHE A  98
PHE A 122
LEU A 149
SER A  80
 None
 1.00A 1wrlC-2f3jA:
undetectable
1wrlD-2f3jA:
undetectable		 1wrlC-2f3jA:
18.24
1wrlD-2f3jA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gai DNA TOPOISOMERASE I

(Thermotoga
maritima) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		4 LEU A  49
LEU A 498
PHE A 535
SER A 541
 None
 0.81A 1wrlC-2gaiA:
undetectable
1wrlD-2gaiA:
undetectable		 1wrlC-2gaiA:
9.78
1wrlD-2gaiA:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h84 STEELY1

(Dictyostelium
discoideum) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 SER A2977
LEU A3028
PHE A3132
LEU A3078
 None
 1.02A 1wrlC-2h84A:
undetectable
1wrlD-2h84A:
undetectable		 1wrlC-2h84A:
13.64
1wrlD-2h84A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inp PHENOL HYDROXYLASE
COMPONENT PHN

(Pseudomonas
stutzeri) 		PF02332
(Phenol_Hydrox)
PF04945
(YHS) 		4 LEU A  72
PHE A  76
LEU A 159
SER A 142
 None
 0.95A 1wrlC-2inpA:
undetectable
1wrlD-2inpA:
undetectable		 1wrlC-2inpA:
11.66
1wrlD-2inpA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inp PHENOL HYDROXYLASE
COMPONENT PHN

(Pseudomonas
stutzeri) 		PF02332
(Phenol_Hydrox)
PF04945
(YHS) 		4 LEU A 206
PHE A 190
PHE A 179
SER A 142
 None
 0.87A 1wrlC-2inpA:
undetectable
1wrlD-2inpA:
undetectable		 1wrlC-2inpA:
11.66
1wrlD-2inpA:
11.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2n7l TROPONIN C/TROPONIN
I CHIMERA

(Homo sapiens) 		PF13833
(EF-hand_8) 		4 LEU C  12
PHE C  27
PHE C  77
MET C  81
 None
None
None
4J4  C  84 ( 4.7A)
 0.92A 1wrlC-2n7lC:
8.7
1wrlD-2n7lC:
8.7		 1wrlC-2n7lC:
84.47
1wrlD-2n7lC:
84.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nqn MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
MOEA

(Escherichia
coli) 		PF00994
(MoCF_biosynth)
PF03453
(MoeA_N)
PF03454
(MoeA_C) 		4 LEU A 265
LEU A 316
PHE A 284
SER A 250
 None
 1.04A 1wrlC-2nqnA:
undetectable
1wrlD-2nqnA:
undetectable		 1wrlC-2nqnA:
10.28
1wrlD-2nqnA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nz0 POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY D
MEMBER 3

(Homo sapiens) 		PF02214
(BTB_2)
PF11601
(Shal-type) 		4 LEU B  44
PHE B  84
PHE B 120
SER B  68
 None
 1.02A 1wrlC-2nz0B:
undetectable
1wrlD-2nz0B:
undetectable		 1wrlC-2nz0B:
19.12
1wrlD-2nz0B:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ow4 CANAVALIA MARITIMA
LECTIN

(Canavalia rosea) 		PF00139
(Lectin_legB) 		4 LEU A  61
PHE A 191
PHE A 111
SER A 215
 None
 1.01A 1wrlC-2ow4A:
undetectable
1wrlD-2ow4A:
undetectable		 1wrlC-2ow4A:
18.57
1wrlD-2ow4A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pg8 DPGC

(Streptomyces
toyocaensis) 		PF00378
(ECH_1) 		4 SER A 379
LEU A 372
LEU A 262
PHE A 231
 None
 0.94A 1wrlC-2pg8A:
undetectable
1wrlD-2pg8A:
undetectable		 1wrlC-2pg8A:
12.29
1wrlD-2pg8A:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		4 SER A 193
LEU A 187
PHE A 132
SER A 119
 None
 0.99A 1wrlC-2q3yA:
undetectable
1wrlD-2q3yA:
undetectable		 1wrlC-2q3yA:
18.72
1wrlD-2q3yA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qib TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N) 		4 LEU A 208
PHE A 186
MET A 190
SER A 193
 None
P6G  A 703 (-4.1A)
None
None
 1.02A 1wrlC-2qibA:
undetectable
1wrlD-2qibA:
undetectable		 1wrlC-2qibA:
17.14
1wrlD-2qibA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdy BH0842 PROTEIN

(Bacillus
halodurans) 		PF14498
(Glyco_hyd_65N_2) 		4 PHE A 484
PHE A 533
LEU A 497
SER A 502
 None
 0.82A 1wrlC-2rdyA:
undetectable
1wrlD-2rdyA:
undetectable		 1wrlC-2rdyA:
8.23
1wrlD-2rdyA:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v26 MYOSIN VI

(Sus scrofa) 		PF00063
(Myosin_head) 		4 LEU A 501
PHE A 757
PHE A 766
LEU A 141
 None
 1.04A 1wrlC-2v26A:
undetectable
1wrlD-2v26A:
undetectable		 1wrlC-2v26A:
8.47
1wrlD-2v26A:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v8s VESICLE TRANSPORT
THROUGH INTERACTION
WITH T-SNARES
HOMOLOG 1B

(Homo sapiens) 		PF05008
(V-SNARE) 		4 PHE V  11
PHE V  73
MET V  77
SER V  79
 None
 0.95A 1wrlC-2v8sV:
undetectable
1wrlD-2v8sV:
undetectable		 1wrlC-2v8sV:
22.02
1wrlD-2v8sV:
22.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2w49 TROPONIN C, SKELETAL
MUSCLE

(Gallus gallus) 		PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		6 LEU 0  13
PHE 0  21
PHE 0  28
LEU 0  48
PHE 0  77
MET 0  81
 None
 1.00A 1wrlC-2w490:
13.2
1wrlD-2w490:
13.0		 1wrlC-2w490:
64.77
1wrlD-2w490:
64.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Pseudomonas
aeruginosa) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 SER A  66
LEU A 134
LEU A 298
PHE A 114
SER A  12
 None
 1.46A 1wrlC-2x3eA:
undetectable
1wrlD-2x3eA:
undetectable		 1wrlC-2x3eA:
13.03
1wrlD-2x3eA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ybx PHOSPHATIDYLINOSITOL
-5-PHOSPHATE
4-KINASE TYPE-2
ALPHA

(Homo sapiens) 		PF01504
(PIP5K) 		5 LEU A 159
PHE A  98
PHE A 112
LEU A  41
SER A  70
 None
 1.24A 1wrlC-2ybxA:
undetectable
1wrlD-2ybxA:
undetectable		 1wrlC-2ybxA:
13.28
1wrlD-2ybxA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 SER A 648
PHE A 702
PHE A 699
MET A 683
 None
 0.98A 1wrlC-2yd0A:
undetectable
1wrlD-2yd0A:
undetectable		 1wrlC-2yd0A:
6.69
1wrlD-2yd0A:
6.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2r NUCLEOSOME ASSEMBLY
PROTEIN

(Saccharomyces
cerevisiae) 		PF00956
(NAP) 		4 PHE A 233
LEU A 193
PHE A 316
SER A 311
 None
 1.04A 1wrlC-2z2rA:
undetectable
1wrlD-2z2rA:
undetectable		 1wrlC-2z2rA:
15.79
1wrlD-2z2rA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bkx SAM-DEPENDENT
METHYLTRANSFERASE

(Lactobacillus
paracasei) 		PF13649
(Methyltransf_25) 		4 SER A 130
LEU A 201
PHE A 144
PHE A 274
 None
 0.95A 1wrlC-3bkxA:
undetectable
1wrlD-3bkxA:
undetectable		 1wrlC-3bkxA:
13.65
1wrlD-3bkxA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d54 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE 1

(Thermotoga
maritima) 		PF13507
(GATase_5) 		4 LEU D  23
PHE D 204
PHE D 130
LEU D 157
 None
 0.88A 1wrlC-3d54D:
undetectable
1wrlD-3d54D:
undetectable		 1wrlC-3d54D:
19.00
1wrlD-3d54D:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e2v 3'-5'-EXONUCLEASE

(Saccharomyces
cerevisiae) 		PF01026
(TatD_DNase) 		4 LEU A 225
LEU A 254
PHE A 241
SER A 219
 None
 0.95A 1wrlC-3e2vA:
undetectable
1wrlD-3e2vA:
undetectable		 1wrlC-3e2vA:
14.36
1wrlD-3e2vA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evr MYOSIN LIGHT CHAIN
KINASE, GREEN
FLUORESCENT PROTEIN,
CALMODULIN-1 CHIMERA

(Aequorea
victoria;
Rattus
norvegicus) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		4 LEU A 307
PHE A 315
PHE A 371
MET A 375
 None
 0.80A 1wrlC-3evrA:
9.9
1wrlD-3evrA:
9.7		 1wrlC-3evrA:
18.81
1wrlD-3evrA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdh SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12771
(SusD-like_2) 		4 SER A 416
PHE A 343
LEU A 292
SER A 409
 None
 0.99A 1wrlC-3fdhA:
undetectable
1wrlD-3fdhA:
undetectable		 1wrlC-3fdhA:
11.36
1wrlD-3fdhA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fle SE_1780 PROTEIN

(Staphylococcus
epidermidis) 		PF06028
(DUF915) 		4 SER A 253
LEU A 246
PHE A 138
PHE A 150
 None
 0.99A 1wrlC-3fleA:
undetectable
1wrlD-3fleA:
undetectable		 1wrlC-3fleA:
17.57
1wrlD-3fleA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fze PROTEIN STE5

(Saccharomyces
cerevisiae) 		PF12194
(Ste5_C) 		4 LEU A 674
PHE A 648
LEU A 767
SER A 626
 None
 1.01A 1wrlC-3fzeA:
undetectable
1wrlD-3fzeA:
undetectable		 1wrlC-3fzeA:
21.11
1wrlD-3fzeA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g3o VACUOLAR TRANSPORTER
CHAPERONE 2

(Saccharomyces
cerevisiae) 		PF09359
(VTC) 		4 LEU A 547
PHE A 469
PHE A 427
SER A 521
 None
None
None
SO4  A1001 (-2.5A)
 1.01A 1wrlC-3g3oA:
undetectable
1wrlD-3g3oA:
undetectable		 1wrlC-3g3oA:
13.94
1wrlD-3g3oA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3grk ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE
(NADH)

(Brucella
melitensis) 		PF13561
(adh_short_C2) 		4 SER A 172
PHE A 116
MET A 120
SER A 123
 None
 0.88A 1wrlC-3grkA:
undetectable
1wrlD-3grkA:
undetectable		 1wrlC-3grkA:
16.38
1wrlD-3grkA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0u PUTATIVE ENOYL-COA
HYDRATASE

(Streptomyces
avermitilis) 		PF00378
(ECH_1) 		4 LEU A 199
PHE A  27
LEU A 103
PHE A  69
 None
 0.90A 1wrlC-3h0uA:
undetectable
1wrlD-3h0uA:
undetectable		 1wrlC-3h0uA:
16.00
1wrlD-3h0uA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjb GLUCOSE-6-PHOSPHATE
ISOMERASE

(Vibrio cholerae) 		PF00342
(PGI) 		4 LEU A 295
PHE A 291
LEU A 205
SER A 273
 None
 1.03A 1wrlC-3hjbA:
undetectable
1wrlD-3hjbA:
undetectable		 1wrlC-3hjbA:
9.12
1wrlD-3hjbA:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hqm SPECKLE-TYPE POZ
PROTEIN

(Homo sapiens) 		PF00917
(MATH) 		4 LEU A  84
PHE A 102
PHE A 104
SER A  54
 None
None
None
SO4  A   4 (-4.4A)
 1.03A 1wrlC-3hqmA:
undetectable
1wrlD-3hqmA:
undetectable		 1wrlC-3hqmA:
17.45
1wrlD-3hqmA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3v PROBABLE SECRETED
SOLUTE-BINDING
LIPOPROTEIN

(Streptomyces
coelicolor) 		PF01547
(SBP_bac_1) 		4 PHE A 322
LEU A  59
PHE A 338
MET A 342
 None
 0.96A 1wrlC-3i3vA:
undetectable
1wrlD-3i3vA:
undetectable		 1wrlC-3i3vA:
13.86
1wrlD-3i3vA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3if8 PROTEIN ZWILCH
HOMOLOG

(Homo sapiens) 		PF09817
(Zwilch) 		5 LEU A 275
PHE B 348
LEU A 303
MET B 356
SER B 359
 None
 1.47A 1wrlC-3if8A:
undetectable
1wrlD-3if8A:
undetectable		 1wrlC-3if8A:
14.67
1wrlD-3if8A:
14.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ifk CALMODULIN

(Rattus
norvegicus) 		PF13499
(EF-hand_7) 		4 LEU A   4
PHE A  12
PHE A  68
MET A  72
 None
 0.76A 1wrlC-3ifkA:
10.5
1wrlD-3ifkA:
10.3		 1wrlC-3ifkA:
60.67
1wrlD-3ifkA:
60.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3io5 RECOMBINATION AND
REPAIR PROTEIN

(Escherichia
virus T4) 		PF00154
(RecA) 		4 SER A  67
LEU A 100
PHE A  88
LEU A 148
 PO4  A   1 (-2.9A)
None
None
None
 1.01A 1wrlC-3io5A:
undetectable
1wrlD-3io5A:
undetectable		 1wrlC-3io5A:
15.84
1wrlD-3io5A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k31 ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE

(Anaplasma
phagocytophilum) 		PF13561
(adh_short_C2) 		4 SER A 171
PHE A 115
MET A 119
SER A 122
 None
 0.90A 1wrlC-3k31A:
undetectable
1wrlD-3k31A:
undetectable		 1wrlC-3k31A:
16.04
1wrlD-3k31A:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN

(Escherichia
coli) 		PF00580
(UvrD-helicase)
PF12705
(PDDEXK_1)
PF13361
(UvrD_C) 		4 SER B1083
LEU B1086
LEU B 977
SER B 950
 None
 1.01A 1wrlC-3k70B:
undetectable
1wrlD-3k70B:
undetectable		 1wrlC-3k70B:
6.47
1wrlD-3k70B:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3le2 SERPIN-ZX

(Arabidopsis
thaliana) 		PF00079
(Serpin) 		4 LEU A 307
PHE A 127
LEU A 154
SER A 289
 None
 0.91A 1wrlC-3le2A:
undetectable
1wrlD-3le2A:
undetectable		 1wrlC-3le2A:
13.37
1wrlD-3le2A:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lws AROMATIC AMINO ACID
BETA-ELIMINATING
LYASE/THREONINE
ALDOLASE

(Exiguobacterium
sibiricum) 		PF01212
(Beta_elim_lyase) 		4 SER A   7
LEU A 319
LEU A 339
PHE A 271
 None
 0.92A 1wrlC-3lwsA:
undetectable
1wrlD-3lwsA:
undetectable		 1wrlC-3lwsA:
15.92
1wrlD-3lwsA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkq COATOMER
BETA'-SUBUNIT
COATOMER SUBUNIT
ALPHA

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF04053
(Coatomer_WDAD) 		4 LEU A 759
PHE A 743
PHE A 714
SER B 708
 None
 0.87A 1wrlC-3mkqA:
undetectable
1wrlD-3mkqA:
undetectable		 1wrlC-3mkqA:
7.72
1wrlD-3mkqA:
7.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE GAMMA-SUBUNIT

(Komagataella
pastoris) 		no annotation 5 LEU I 242
PHE I  58
PHE I 103
MET I 107
SER I 109
 None
 1.50A 1wrlC-3opyI:
undetectable
1wrlD-3opyI:
undetectable		 1wrlC-3opyI:
14.25
1wrlD-3opyI:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pie 5'->3'
EXORIBONUCLEASE
(XRN1)

(Kluyveromyces
lactis) 		PF03159
(XRN_N) 		4 LEU A 143
PHE A  81
MET A  36
SER A  38
 None
 1.00A 1wrlC-3pieA:
undetectable
1wrlD-3pieA:
undetectable		 1wrlC-3pieA:
6.07
1wrlD-3pieA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvc TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Yersinia pestis) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		4 LEU A 142
PHE A 332
PHE A 325
LEU A 627
 None
None
None
FAD  A 690 (-4.3A)
 1.00A 1wrlC-3pvcA:
undetectable
1wrlD-3pvcA:
undetectable		 1wrlC-3pvcA:
9.00
1wrlD-3pvcA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q8d DNA REPAIR PROTEIN
RECO

(Escherichia
coli) 		PF02565
(RecO_C)
PF11967
(RecO_N) 		4 PHE A 183
PHE A 148
LEU A 139
PHE A 172
 None
 0.94A 1wrlC-3q8dA:
undetectable
1wrlD-3q8dA:
undetectable		 1wrlC-3q8dA:
16.25
1wrlD-3q8dA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qlb ENANTIO-PYOCHELIN
RECEPTOR

(Pseudomonas
fluorescens) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 SER A  38
LEU A 140
LEU A  75
SER A  54
 None
 0.93A 1wrlC-3qlbA:
undetectable
1wrlD-3qlbA:
undetectable		 1wrlC-3qlbA:
9.72
1wrlD-3qlbA:
9.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qrx CENTRIN

(Chlamydomonas
reinhardtii) 		PF13499
(EF-hand_7) 		4 LEU A  22
PHE A  37
PHE A  86
MET A  90
 None
 0.68A 1wrlC-3qrxA:
11.6
1wrlD-3qrxA:
11.9		 1wrlC-3qrxA:
42.61
1wrlD-3qrxA:
42.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r11 ENZYME OF ENOLASE
SUPERFAMILY

(Francisella
philomiragia) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 361
PHE A 353
PHE A 355
SER A  33
 None
 0.94A 1wrlC-3r11A:
undetectable
1wrlD-3r11A:
undetectable		 1wrlC-3r11A:
15.77
1wrlD-3r11A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rg1 CD180 MOLECULE

(Bos taurus) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 LEU A 247
PHE A 180
LEU A 166
PHE A 206
 None
 0.88A 1wrlC-3rg1A:
undetectable
1wrlD-3rg1A:
undetectable		 1wrlC-3rg1A:
8.61
1wrlD-3rg1A:
8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rjo ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1

(Homo sapiens) 		PF11838
(ERAP1_C) 		4 SER A 648
PHE A 702
PHE A 699
MET A 683
 EDO  A   1 ( 4.3A)
None
None
None
 0.94A 1wrlC-3rjoA:
undetectable
1wrlD-3rjoA:
undetectable		 1wrlC-3rjoA:
11.63
1wrlD-3rjoA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqn CONSERVED DOMAIN
PROTEIN

(Enterococcus
faecalis) 		PF05043
(Mga) 		4 SER A 194
PHE A 264
LEU A 282
PHE A 261
 None
 1.03A 1wrlC-3sqnA:
2.0
1wrlD-3sqnA:
undetectable		 1wrlC-3sqnA:
10.77
1wrlD-3sqnA:
10.77