SIMILAR PATTERNS OF AMINO ACIDS FOR 1WRL_C_TFPC208_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dl2 CLASS I
ALPHA-1,2-MANNOSIDAS
E

(Saccharomyces
cerevisiae) 		PF01532
(Glyco_hydro_47) 		4 PHE A 523
LEU A  93
PHE A 442
MET A 441
 None
 1.20A 1wrlC-1dl2A:
undetectable		 1wrlC-1dl2A:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eh5 PALMITOYL PROTEIN
THIOESTERASE 1

(Bos taurus) 		PF02089
(Palm_thioest) 		4 LEU A 269
PHE A 282
MET A 227
SER A 138
 None
 1.24A 1wrlC-1eh5A:
undetectable		 1wrlC-1eh5A:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1foe T-LYMPHOMA INVASION
AND METASTASIS
INDUCING PROTEIN 1

(Mus musculus) 		PF00169
(PH)
PF00621
(RhoGEF) 		4 PHE A1098
LEU A1048
PHE A1139
MET A1224
 None
 1.06A 1wrlC-1foeA:
undetectable		 1wrlC-1foeA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2t 80 KDA NUCLEAR CAP
BINDING PROTEIN

(Homo sapiens) 		PF02854
(MIF4G)
PF09088
(MIF4G_like)
PF09090
(MIF4G_like_2) 		4 PHE C 360
LEU C 402
PHE C 289
MET C 291
 None
 1.20A 1wrlC-1h2tC:
undetectable		 1wrlC-1h2tC:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hlb HEMOGLOBIN (DEOXY)

(Molpadia
arenicola) 		PF00042
(Globin) 		4 PHE A 145
LEU A 125
MET A  81
SER A  82
 None
None
HEM  A 158 ( 4.8A)
None
 1.14A 1wrlC-1hlbA:
undetectable		 1wrlC-1hlbA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0h NEOPULLULANASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		4 PHE A 387
LEU A 420
PHE A 397
MET A 401
 None
 1.15A 1wrlC-1j0hA:
undetectable		 1wrlC-1j0hA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kqf FORMATE
DEHYDROGENASE,
NITRATE-INDUCIBLE,
MAJOR SUBUNIT

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 PHE A 180
LEU A 675
PHE A 553
SER A 160
 None
 1.11A 1wrlC-1kqfA:
undetectable		 1wrlC-1kqfA:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lwh 4-ALPHA-GLUCANOTRANS
FERASE

(Thermotoga
maritima) 		PF00128
(Alpha-amylase)
PF09178
(DUF1945) 		4 PHE A 205
LEU A  90
PHE A 201
MET A 191
 None
 0.97A 1wrlC-1lwhA:
undetectable		 1wrlC-1lwhA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nne DNA MISMATCH REPAIR
PROTEIN MUTS

(Thermus
aquaticus) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		4 PHE A  34
LEU A 107
PHE A  43
SER A  63
 None
 1.23A 1wrlC-1nneA:
undetectable		 1wrlC-1nneA:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nty TRIPLE FUNCTIONAL
DOMAIN PROTEIN

(Homo sapiens) 		PF00169
(PH)
PF00621
(RhoGEF) 		4 PHE A1296
LEU A1241
PHE A1321
MET A1398
 None
 0.97A 1wrlC-1ntyA:
undetectable		 1wrlC-1ntyA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pex COLLAGENASE-3

(Homo sapiens) 		PF00045
(Hemopexin) 		4 PHE A 320
PHE A 302
MET A 295
SER A 289
 None
 1.25A 1wrlC-1pexA:
undetectable		 1wrlC-1pexA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pu7 3-METHYLADENINE DNA
GLYCOSYLASE

(Helicobacter
pylori) 		PF00633
(HHH)
PF00730
(HhH-GPD) 		4 PHE A 174
LEU A   2
PHE A 202
SER A  13
 None
 1.27A 1wrlC-1pu7A:
undetectable		 1wrlC-1pu7A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q32 TYROSYL-DNA
PHOSPHODIESTERASE

(Saccharomyces
cerevisiae) 		PF06087
(Tyr-DNA_phospho) 		4 LEU A 317
PHE A 411
MET A 406
SER A 402
 None
 1.19A 1wrlC-1q32A:
undetectable		 1wrlC-1q32A:
9.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qx2 VITAMIN D-DEPENDENT
CALCIUM-BINDING
PROTEIN, INTESTINAL

(Bos taurus) 		PF00036
(EF-hand_1) 		4 PHE A  13
PHE A  66
MET A  70
SER A  74
 None
 1.23A 1wrlC-1qx2A:
8.2		 1wrlC-1qx2A:
38.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ti8 HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 PHE A 245
LEU A 235
PHE A 125
MET A 123
 None
 1.23A 1wrlC-1ti8A:
undetectable		 1wrlC-1ti8A:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txg GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]

(Archaeoglobus
fulgidus) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		4 LEU A  77
PHE A 169
MET A 165
SER A 161
 None
 1.27A 1wrlC-1txgA:
undetectable		 1wrlC-1txgA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w7p VPS22, YPL002C

(Saccharomyces
cerevisiae) 		PF04157
(EAP30) 		4 PHE A  46
LEU A  54
MET A  67
SER A  69
 None
 1.20A 1wrlC-1w7pA:
undetectable		 1wrlC-1w7pA:
18.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wrk TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES

(Homo sapiens) 		PF13833
(EF-hand_8) 		4 PHE A  27
LEU A  48
PHE A  77
MET A  81
 TFP  A 204 (-4.4A)
TFP  A 202 (-4.1A)
None
TFP  A 202 ( 3.3A)
 0.35A 1wrlC-1wrkA:
17.3		 1wrlC-1wrkA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y7i SALICYLIC
ACID-BINDING PROTEIN
2

(Nicotiana
tabacum) 		PF12697
(Abhydrolase_6) 		4 LEU A 160
PHE A 136
MET A 149
SER A 179
 None
None
SAL  A 501 ( 4.6A)
None
 1.22A 1wrlC-1y7iA:
undetectable		 1wrlC-1y7iA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yoc HYPOTHETICAL PROTEIN
PA1835

(Pseudomonas
aeruginosa) 		PF14539
(DUF4442) 		4 PHE A  34
PHE A  16
MET A   4
SER A   2
 None
 1.06A 1wrlC-1yocA:
undetectable		 1wrlC-1yocA:
22.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2d58 ALLOGRAFT
INFLAMMATORY FACTOR
1

(Homo sapiens) 		no annotation 4 PHE A  57
LEU A  74
PHE A 106
MET A 110
 None
 1.25A 1wrlC-2d58A:
8.6		 1wrlC-2d58A:
32.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2d58 ALLOGRAFT
INFLAMMATORY FACTOR
1

(Homo sapiens) 		no annotation 4 PHE A  57
LEU A  77
PHE A 106
MET A 110
 None
 1.13A 1wrlC-2d58A:
8.6		 1wrlC-2d58A:
32.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkh 3-HYDROXYBENZOATE
HYDROXYLASE

(Comamonas
testosteroni) 		PF01494
(FAD_binding_3)
PF07976
(Phe_hydrox_dim) 		4 PHE A 633
LEU A 621
PHE A 636
SER A 452
 None
 1.25A 1wrlC-2dkhA:
undetectable		 1wrlC-2dkhA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Staphylococcus
aureus) 		PF01425
(Amidase) 		4 PHE A 351
LEU A  96
MET A 129
SER A 154
 None
None
None
GLN  A 501 (-2.9A)
 1.06A 1wrlC-2f2aA:
undetectable		 1wrlC-2f2aA:
12.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f2p CALMODULIN FUSED
WITH
CALMODULIN-BINDING
DOMAIN OF
CALCINEURIN

(Bos taurus) 		PF13499
(EF-hand_7) 		4 PHE A  19
LEU A  39
PHE A  68
MET A  72
 None
 1.00A 1wrlC-2f2pA:
11.3		 1wrlC-2f2pA:
61.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gaf POLY(A) POLYMERASE
CATALYTIC SUBUNIT

(Vaccinia virus) 		PF03296
(Pox_polyA_pol)
PF12629
(Pox_polyA_pol_C)
PF12630
(Pox_polyA_pol_N) 		4 LEU D 313
PHE D 289
MET D 145
SER D 144
 None
 1.29A 1wrlC-2gafD:
undetectable		 1wrlC-2gafD:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjz IONIZED
CALCIUM-BINDING
ADAPTER MOLECULE 2

(Homo sapiens) 		no annotation 4 PHE B  59
LEU B  79
PHE B 108
MET B 112
 None
 1.22A 1wrlC-2jjzB:
8.3		 1wrlC-2jjzB:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2loe 6-CYSTEINE PROTEIN,
PUTATIVE

(Plasmodium
falciparum) 		PF07422
(s48_45) 		4 PHE A 109
LEU A  99
PHE A 123
SER A  17
 PHE  A 109 ( 1.4A)
LEU  A  99 ( 0.6A)
PHE  A 123 ( 1.4A)
SER  A  17 ( 0.0A)
 1.20A 1wrlC-2loeA:
undetectable		 1wrlC-2loeA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ook HYPOTHETICAL PROTEIN

(Shewanella
frigidimarina) 		PF11964
(SpoIIAA-like) 		4 PHE A 106
LEU A  74
PHE A  84
SER A  46
 None
 1.14A 1wrlC-2ookA:
undetectable		 1wrlC-2ookA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q4n UNCHARACTERIZED
PROTEIN AT1G79260

(Arabidopsis
thaliana) 		PF08768
(DUF1794) 		4 PHE A 135
LEU A 163
PHE A  82
SER A  53
 None
 1.08A 1wrlC-2q4nA:
undetectable		 1wrlC-2q4nA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqk NEUROPILIN-2

(Homo sapiens) 		PF00431
(CUB)
PF00754
(F5_F8_type_C) 		4 PHE A 191
LEU A 245
PHE A 260
SER A 150
 None
 1.22A 1wrlC-2qqkA:
undetectable		 1wrlC-2qqkA:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqm NEUROPILIN-1

(Homo sapiens) 		PF00431
(CUB)
PF00754
(F5_F8_type_C) 		4 PHE A 189
LEU A 243
PHE A 258
SER A 148
 None
 1.21A 1wrlC-2qqmA:
undetectable		 1wrlC-2qqmA:
12.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rob CALMODULIN

(Glycine max) 		PF13499
(EF-hand_7) 		4 PHE A  92
LEU A 112
PHE A 141
MET A 145
 None
 1.11A 1wrlC-2robA:
10.8		 1wrlC-2robA:
40.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v2u GAMMA CRYSTALLIN C

(Mus musculus) 		PF00030
(Crystall) 		4 PHE A   5
LEU A  57
PHE A  29
SER A  72
 None
 1.28A 1wrlC-2v2uA:
undetectable		 1wrlC-2v2uA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2j CARBONIC
ANHYDRASE-RELATED
PROTEIN

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 PHE A 117
LEU A 206
PHE A 250
SER A 243
 None
 1.11A 1wrlC-2w2jA:
undetectable		 1wrlC-2w2jA:
14.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2w49 TROPONIN C, SKELETAL
MUSCLE

(Gallus gallus) 		PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		4 PHE 0  28
LEU 0  48
PHE 0  77
MET 0  81
 None
 0.91A 1wrlC-2w490:
13.2		 1wrlC-2w490:
64.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y0n MALE-SPECIFIC LETHAL
1 HOMOLOG
MALE-SPECIFIC LETHAL
3 HOMOLOG

(Homo sapiens;
Mus musculus) 		PF05712
(MRG)
no annotation 		4 PHE E 577
LEU A 459
PHE A 472
MET A 470
 None
 1.29A 1wrlC-2y0nE:
undetectable		 1wrlC-2y0nE:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zts PUTATIVE
UNCHARACTERIZED
PROTEIN PH0186

(Pyrococcus
horikoshii) 		PF06745
(ATPase) 		4 PHE A  64
PHE A  85
MET A  78
SER A  80
 None
None
None
ADP  A1903 (-2.6A)
 1.23A 1wrlC-2ztsA:
undetectable		 1wrlC-2ztsA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afb PUTATIVE CHITINASE

(Pyrococcus
furiosus) 		no annotation 4 PHE A 523
LEU A 505
PHE A 552
MET A 572
 None
 1.09A 1wrlC-3afbA:
undetectable		 1wrlC-3afbA:
13.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b32 CALMODULIN

(Rattus
norvegicus) 		PF13499
(EF-hand_7) 		4 PHE A  19
LEU A  39
PHE A  68
MET A  72
 None
 1.04A 1wrlC-3b32A:
11.2		 1wrlC-3b32A:
59.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c37 PEPTIDASE, M48
FAMILY

(Geobacter
sulfurreducens) 		PF01435
(Peptidase_M48) 		4 PHE A  26
LEU A 128
PHE A 149
MET A 155
 None
 1.27A 1wrlC-3c37A:
undetectable		 1wrlC-3c37A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3db2 PUTATIVE
NADPH-DEPENDENT
OXIDOREDUCTASE

(Desulfitobacterium
hafniense) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 PHE A 240
LEU A 131
PHE A 257
SER A 263
 None
 1.22A 1wrlC-3db2A:
undetectable		 1wrlC-3db2A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dcx PROTEIN OF UNKNOWN
FUNCTION (DUF1696)
WITH
PLECKSTRIN-HOMOLOGY
DOMAINS

(Shewanella
loihica) 		PF08000
(bPH_1) 		4 PHE A  44
LEU A 102
PHE A  46
SER A 123
 MPD  A   5 ( 3.8A)
None
None
None
 1.17A 1wrlC-3dcxA:
undetectable		 1wrlC-3dcxA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0x LIPASE-ESTERASE
RELATED PROTEIN

(Clostridium
acetobutylicum) 		PF12146
(Hydrolase_4) 		4 PHE A 155
LEU A 134
PHE A 225
SER A  89
 None
None
None
OXE  A 243 (-2.8A)
 1.29A 1wrlC-3e0xA:
undetectable		 1wrlC-3e0xA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evr MYOSIN LIGHT CHAIN
KINASE, GREEN
FLUORESCENT PROTEIN,
CALMODULIN-1 CHIMERA

(Aequorea
victoria;
Rattus
norvegicus) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		4 PHE A 395
LEU A 415
PHE A 444
MET A 448
 None
 1.26A 1wrlC-3evrA:
9.9		 1wrlC-3evrA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1

(Homo sapiens) 		PF00632
(HECT) 		4 PHE A4132
PHE A4081
MET A4073
SER A4070
 None
 1.28A 1wrlC-3g1nA:
undetectable		 1wrlC-3g1nA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jxf RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE ZETA

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 PHE A 128
LEU A 220
PHE A 263
SER A 256
 None
 0.97A 1wrlC-3jxfA:
undetectable		 1wrlC-3jxfA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8p PROTEIN TRANSPORT
PROTEIN SEC39

(Saccharomyces
cerevisiae) 		PF08314
(Sec39) 		4 PHE D 252
LEU D 305
PHE D 236
SER D 270
 None
 1.25A 1wrlC-3k8pD:
undetectable		 1wrlC-3k8pD:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kf9 CALTRACTIN

(Scherffelia
dubia) 		PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		4 PHE A  36
LEU A  56
PHE A  85
MET A  89
 None
 1.25A 1wrlC-3kf9A:
11.0		 1wrlC-3kf9A:
28.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kkg PUTATIVE SNOAL-LIKE
POLYKETIDE CYCLASE

(Jannaschia sp.
CCS1) 		PF07366
(SnoaL) 		4 PHE A  45
LEU A 117
PHE A 143
MET A 153
 None
 1.27A 1wrlC-3kkgA:
undetectable		 1wrlC-3kkgA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n5l BINDING PROTEIN
COMPONENT OF ABC
PHOSPHONATE
TRANSPORTER

(Pseudomonas
aeruginosa) 		PF12974
(Phosphonate-bd) 		4 LEU A 237
PHE A 249
MET A  54
SER A  55
 None
 1.20A 1wrlC-3n5lA:
undetectable		 1wrlC-3n5lA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n5l BINDING PROTEIN
COMPONENT OF ABC
PHOSPHONATE
TRANSPORTER

(Pseudomonas
aeruginosa) 		PF12974
(Phosphonate-bd) 		4 PHE A 104
LEU A 237
PHE A 249
SER A  55
 None
 1.18A 1wrlC-3n5lA:
undetectable		 1wrlC-3n5lA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n7x CAPSID PROTEIN

(Decapod
penstyldensovirus
1) 		PF16530
(IHHNV_capsid) 		4 PHE A  56
LEU A  81
PHE A  58
MET A 266
 None
 1.23A 1wrlC-3n7xA:
undetectable		 1wrlC-3n7xA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozq SERPIN48

(Tenebrio
molitor) 		PF00079
(Serpin) 		4 PHE A  24
LEU A  94
PHE A  79
SER A  63
 None
 1.23A 1wrlC-3ozqA:
undetectable		 1wrlC-3ozqA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6

(Saccharomyces
cerevisiae) 		PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD) 		4 PHE A 962
LEU A 973
PHE A 954
SER A 932
 None
 1.13A 1wrlC-3psfA:
undetectable		 1wrlC-3psfA:
7.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r4d SPIKE GLYCOPROTEIN

(Murine
coronavirus) 		PF16451
(Spike_NTD) 		4 PHE B 204
LEU B 195
PHE B 206
SER B 151
 None
 0.96A 1wrlC-3r4dB:
undetectable		 1wrlC-3r4dB:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sq7 TYROSYL-DNA
PHOSPHODIESTERASE 1

(Saccharomyces
cerevisiae) 		PF06087
(Tyr-DNA_phospho) 		4 LEU A 317
PHE A 411
MET A 406
SER A 402
 None
 1.26A 1wrlC-3sq7A:
undetectable		 1wrlC-3sq7A:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tva XYLOSE ISOMERASE
DOMAIN PROTEIN TIM
BARREL

(Planctopirus
limnophila) 		PF01261
(AP_endonuc_2) 		4 LEU A 154
PHE A  71
MET A 101
SER A 105
 None
 1.17A 1wrlC-3tvaA:
undetectable		 1wrlC-3tvaA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0k RCAMP

(Entacmaea
quadricolor) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		4 PHE A 313
LEU A 333
PHE A 362
MET A 366
 None
 1.02A 1wrlC-3u0kA:
10.3		 1wrlC-3u0kA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5n PUTATIVE
RHAMNOSIDASE

(Streptomyces
avermitilis) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		4 LEU A 625
PHE A 598
MET A 655
SER A 657
 None
RAM  A1204 (-3.6A)
None
None
 1.07A 1wrlC-3w5nA:
undetectable		 1wrlC-3w5nA:
7.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3w ARCHAEMETZINCIN

(Archaeoglobus
fulgidus) 		PF07998
(Peptidase_M54) 		4 PHE A  26
LEU A  66
PHE A 150
MET A 134
 None
 1.17A 1wrlC-4a3wA:
undetectable		 1wrlC-4a3wA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayj BOGT -
METAL-INDEPENDENT
GLYCOSYLTRANSFERASE

(Bacteroides
ovatus) 		PF03414
(Glyco_transf_6) 		4 PHE A  92
LEU A 208
PHE A  28
SER A 102
 None
 1.28A 1wrlC-4ayjA:
undetectable		 1wrlC-4ayjA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cgy DNA TOPOISOMERASE
3-ALPHA

(Homo sapiens) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		4 PHE A 221
LEU A 226
MET A 575
SER A 574
 None
 1.20A 1wrlC-4cgyA:
undetectable		 1wrlC-4cgyA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvq GLUTAMATE-PYRUVATE
AMINOTRANSFERASE
ALAA

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		4 PHE A 205
LEU A 231
PHE A 235
MET A 252
 None
 1.20A 1wrlC-4cvqA:
undetectable		 1wrlC-4cvqA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d1g FIBER PROTEIN

(Snake
atadenovirus A) 		no annotation 4 PHE A 256
LEU A 331
PHE A 258
SER A 339
 None
 1.29A 1wrlC-4d1gA:
undetectable		 1wrlC-4d1gA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d47 LEVANSUCRASE

(Erwinia
amylovora) 		PF02435
(Glyco_hydro_68) 		4 PHE A 207
LEU A 259
PHE A 293
SER A 324
 None
 0.94A 1wrlC-4d47A:
undetectable		 1wrlC-4d47A:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f8a POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY H
MEMBER 1

(Mus musculus) 		PF00027
(cNMP_binding) 		4 PHE A 620
LEU A 697
PHE A 582
SER A 688
 None
 1.10A 1wrlC-4f8aA:
undetectable		 1wrlC-4f8aA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f9u CG32412

(Drosophila
melanogaster) 		PF04389
(Peptidase_M28) 		4 PHE A 318
LEU A 164
PHE A 314
SER A 132
 None
 1.17A 1wrlC-4f9uA:
undetectable		 1wrlC-4f9uA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4flc ADENYLOSUCCINATE
LYASE

(Homo sapiens) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		4 LEU A 311
PHE A  30
MET A  26
SER A  23
 None
 0.84A 1wrlC-4flcA:
undetectable		 1wrlC-4flcA:
11.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gow CALMODULIN

(Homo sapiens) 		PF13499
(EF-hand_7) 		4 PHE D  92
LEU D 112
PHE D 141
MET D 145
 PHE  D  92 ( 1.3A)
LEU  D 112 ( 0.6A)
PHE  D 141 ( 1.3A)
MET  D 145 ( 0.0A)
 1.05A 1wrlC-4gowD:
11.4		 1wrlC-4gowD:
67.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h7u PYRANOSE
DEHYDROGENASE

(Leucoagaricus
meleagris) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 PHE A 178
PHE A 479
MET A 473
SER A 469
 None
 1.01A 1wrlC-4h7uA:
undetectable		 1wrlC-4h7uA:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i2y RGECO1

(Discosoma sp.;
Gallus gallus;
Rattus
norvegicus) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		4 PHE A 395
LEU A 415
PHE A 444
MET A 448
 None
 1.25A 1wrlC-4i2yA:
10.5		 1wrlC-4i2yA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iik ADENOSINE
MONOPHOSPHATE-PROTEI
N HYDROLASE SIDD

(Legionella
pneumophila) 		no annotation 4 PHE A 123
LEU A 131
PHE A 169
MET A 171
 None
 1.19A 1wrlC-4iikA:
undetectable		 1wrlC-4iikA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imv RICIN

(Ricinus
communis) 		PF00161
(RIP) 		4 PHE A  93
LEU A  72
PHE A 117
SER A 155
 None
 1.13A 1wrlC-4imvA:
undetectable		 1wrlC-4imvA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf7 NUP188

(Thermothelomyces
thermophila) 		PF10487
(Nup188) 		4 PHE A 604
LEU A 721
PHE A 600
SER A 712
 None
 0.81A 1wrlC-4kf7A:
undetectable		 1wrlC-4kf7A:
5.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l3a INTERNALIN K

(Listeria
monocytogenes) 		no annotation 4 PHE A 284
LEU A 252
MET A 259
SER A 257
 None
 1.22A 1wrlC-4l3aA:
undetectable		 1wrlC-4l3aA:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l3f INTERNALIN K

(Listeria
monocytogenes) 		no annotation 4 PHE A 284
LEU A 252
MET A 259
SER A 257
 None
 1.23A 1wrlC-4l3fA:
undetectable		 1wrlC-4l3fA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4li2 LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4

(Xenopus
tropicalis) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		4 PHE A 341
LEU A 370
PHE A 315
SER A 354
 None
 0.89A 1wrlC-4li2A:
undetectable		 1wrlC-4li2A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mq0 PARKIA BIGLOBOSA
LECTIN (PBL)

(Parkia
biglobosa) 		PF01419
(Jacalin) 		4 PHE A 192
LEU A 244
PHE A 170
SER A 155
 None
 1.23A 1wrlC-4mq0A:
undetectable		 1wrlC-4mq0A:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ntj P2Y PURINOCEPTOR
12,SOLUBLE
CYTOCHROME B562,P2Y
PURINOCEPTOR 12

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		4 LEU A 293
PHE A  77
MET A  73
SER A  69
 None
 1.15A 1wrlC-4ntjA:
undetectable		 1wrlC-4ntjA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozx ALGINATE LYASE

(Klebsiella
pneumoniae) 		PF08787
(Alginate_lyase2) 		4 PHE A 296
LEU A 137
PHE A  76
SER A  35
 None
 1.21A 1wrlC-4ozxA:
undetectable		 1wrlC-4ozxA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 PHE A 829
LEU A 938
PHE A 835
MET A 840
 CV7  A1987 (-4.9A)
CV7  A1987 ( 3.9A)
None
CV7  A1987 ( 3.7A)
 1.23A 1wrlC-4udbA:
undetectable		 1wrlC-4udbA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4umi FIBER PROTEIN

(Snake
atadenovirus A) 		no annotation 4 PHE A 256
LEU A 331
PHE A 258
SER A 339
 None
 1.22A 1wrlC-4umiA:
undetectable		 1wrlC-4umiA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7y DIPHOSPHOMEVALONATE
DECARBOXYLASE

(Sulfolobus
solfataricus) 		PF00288
(GHMP_kinases_N) 		4 LEU A  39
PHE A 234
MET A 238
SER A 242
 None
 1.02A 1wrlC-4z7yA:
undetectable		 1wrlC-4z7yA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5en2 PRE-GLYCOPROTEIN
POLYPROTEIN GP
COMPLEX

(Argentinian
mammarenavirus) 		no annotation 4 LEU C  91
PHE C 192
MET C 215
SER C 111
 None
 1.21A 1wrlC-5en2C:
undetectable		 1wrlC-5en2C:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyi NON-STRUCTURAL
PROTEIN 11

(Porcine
reproductive
and respiratory
syndrome virus) 		no annotation 4 PHE A 205
LEU A  50
PHE A 103
SER A   3
 None
None
None
PG0  A 303 (-3.6A)
 1.18A 1wrlC-5eyiA:
undetectable		 1wrlC-5eyiA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyt ADENYLOSUCCINATE
LYASE

(Schistosoma
mansoni) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		4 LEU A 306
PHE A  24
MET A  20
SER A  17
 None
 0.82A 1wrlC-5eytA:
undetectable		 1wrlC-5eytA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fi0 PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE-
DEPENDENT RAC
EXCHANGER 1
PROTEIN,PHOSPHATIDYL
INOSITOL
3,4,5-TRISPHOSPHATE-
DEPENDENT RAC
EXCHANGER 1 PROTEIN

(Homo sapiens) 		PF00169
(PH)
PF00621
(RhoGEF) 		4 PHE A 113
LEU A 131
PHE A 142
MET A 230
 None
 1.29A 1wrlC-5fi0A:
undetectable		 1wrlC-5fi0A:
12.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h7d ZPA963,CALMODULIN

(Caenorhabditis
elegans;
synthetic
construct) 		PF02216
(B)
PF13499
(EF-hand_7) 		4 PHE E 164
LEU E 184
PHE E 213
MET E 217
 None
 1.23A 1wrlC-5h7dE:
8.6		 1wrlC-5h7dE:
40.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hc4 LIPOLYTIC ENZYME

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		4 PHE A 322
LEU A 113
PHE A  19
MET A  22
 None
GOL  A 401 (-4.3A)
None
None
 1.29A 1wrlC-5hc4A:
undetectable		 1wrlC-5hc4A:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k7l POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY H
MEMBER 1

(Rattus
norvegicus) 		PF00027
(cNMP_binding)
PF00520
(Ion_trans)
PF13426
(PAS_9) 		4 PHE A 593
LEU A 670
PHE A 555
SER A 661
 None
 1.02A 1wrlC-5k7lA:
undetectable		 1wrlC-5k7lA:
7.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lnb UBIQUITIN-LIKE-SPECI
FIC PROTEASE 2

(Saccharomyces
cerevisiae) 		PF02902
(Peptidase_C48) 		4 PHE B 185
LEU B 135
PHE B  87
MET B  83
 None
 1.04A 1wrlC-5lnbB:
undetectable		 1wrlC-5lnbB:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o33 KALIRIN

(Rattus
norvegicus) 		PF00621
(RhoGEF) 		4 PHE B1296
LEU B1241
PHE B1321
MET B1398
 None
 0.95A 1wrlC-5o33B:
undetectable		 1wrlC-5o33B:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v4l ADENYLOSUCCINATE
LYASE

(Cryptococcus
neoformans) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		4 LEU A 248
PHE A  21
MET A  17
SER A  14
 None
 1.22A 1wrlC-5v4lA:
undetectable		 1wrlC-5v4lA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v4l ADENYLOSUCCINATE
LYASE

(Cryptococcus
neoformans) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		4 LEU A 304
PHE A  21
MET A  17
SER A  14
 None
 0.97A 1wrlC-5v4lA:
undetectable		 1wrlC-5v4lA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5veu CYTOCHROME P450 3A5

(Homo sapiens) 		no annotation 4 PHE A 271
LEU A 290
PHE A 189
SER A 250
 None
 1.29A 1wrlC-5veuA:
undetectable		 1wrlC-5veuA:
13.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w88 TROPONIN C, TROPONIN
I

(Homo sapiens) 		PF00992
(Troponin)
PF13833
(EF-hand_8) 		4 PHE A  27
LEU A  48
PHE A  77
MET A  81
 9XG  A 201 (-3.8A)
9XG  A 201 ( 4.8A)
9XG  A 201 (-3.8A)
9XG  A 201 ( 4.6A)
 1.20A 1wrlC-5w88A:
12.0		 1wrlC-5w88A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wrr PSEUDOKINASE FAM20A

(Homo sapiens) 		PF06702
(Fam20C) 		4 PHE A 417
LEU A 117
PHE A 425
SER A 175
 None
 1.18A 1wrlC-5wrrA:
undetectable		 1wrlC-5wrrA:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wth POLYPROTEIN

(Hepatovirus A) 		PF12944
(HAV_VP) 		4 PHE A 134
LEU A 113
MET A  89
SER A  92
 None
 1.26A 1wrlC-5wthA:
undetectable		 1wrlC-5wthA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gh2 LAMINARIBIOSE
PHOSPHORYLASE

(Paenibacillus
sp. YM1) 		no annotation 4 PHE A 273
LEU A 307
PHE A  74
SER A 131
 None
 1.30A 1wrlC-6gh2A:
undetectable		 1wrlC-6gh2A:
20.45