SIMILAR PATTERNS OF AMINO ACIDS FOR 1WRL_B_TFPB203_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ac5 KEX1(DELTA)P

(Saccharomyces
cerevisiae) 		PF00450
(Peptidase_S10) 		4 PHE A 322
VAL A 328
LEU A 332
SER A  80
 None
 1.01A 1wrlB-1ac5A:
undetectable		 1wrlB-1ac5A:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d5f E6AP HECT CATALYTIC
DOMAIN, E3 LIGASE

(Homo sapiens) 		PF00632
(HECT) 		4 PHE A 578
VAL A 614
LEU A 618
PHE A 567
 None
 1.01A 1wrlB-1d5fA:
undetectable		 1wrlB-1d5fA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dmu BGLI RESTRICTION
ENDONUCLEASE

(Bacillus
subtilis) 		PF14562
(Endonuc_BglI) 		4 PHE A 262
VAL A 278
LEU A 157
PHE A 247
 None
 1.07A 1wrlB-1dmuA:
undetectable		 1wrlB-1dmuA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f5n INTERFERON-INDUCED
GUANYLATE-BINDING
PROTEIN 1

(Homo sapiens) 		PF02263
(GBP)
PF02841
(GBP_C) 		4 PHE A 126
VAL A  44
LEU A 101
PHE A 178
 None
 1.03A 1wrlB-1f5nA:
undetectable		 1wrlB-1f5nA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f5n INTERFERON-INDUCED
GUANYLATE-BINDING
PROTEIN 1

(Homo sapiens) 		PF02263
(GBP)
PF02841
(GBP_C) 		4 PHE A 126
VAL A  44
LEU A 101
PHE A 230
 None
 1.04A 1wrlB-1f5nA:
undetectable		 1wrlB-1f5nA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz7 LIPASE 2

(Diutina rugosa) 		PF00135
(COesterase) 		4 PHE A  87
VAL A 296
LEU A 302
PHE A  69
 None
 1.06A 1wrlB-1gz7A:
2.3		 1wrlB-1gz7A:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jne IMAGINAL DISC GROWTH
FACTOR-2

(Drosophila
melanogaster) 		PF00704
(Glyco_hydro_18) 		4 PHE A 173
VAL A 177
LEU A 191
PHE A 205
 None
 1.03A 1wrlB-1jneA:
undetectable		 1wrlB-1jneA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m6u NDT80 PROTEIN

(Saccharomyces
cerevisiae) 		PF05224
(NDT80_PhoG) 		4 VAL A  78
LEU A 137
PHE A 130
SER A 240
 None
 0.98A 1wrlB-1m6uA:
undetectable		 1wrlB-1m6uA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mnn NDT80 PROTEIN

(Saccharomyces
cerevisiae) 		PF05224
(NDT80_PhoG) 		4 VAL A  78
LEU A 137
PHE A 130
SER A 240
 None
 0.99A 1wrlB-1mnnA:
undetectable		 1wrlB-1mnnA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mpx ALPHA-AMINO ACID
ESTER HYDROLASE

(Xanthomonas
citri) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		4 PHE A 372
VAL A 193
LEU A 191
SER A 164
 None
 0.96A 1wrlB-1mpxA:
undetectable		 1wrlB-1mpxA:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nty TRIPLE FUNCTIONAL
DOMAIN PROTEIN

(Homo sapiens) 		PF00169
(PH)
PF00621
(RhoGEF) 		4 PHE A1296
LEU A1241
PHE A1321
MET A1398
 None
 0.97A 1wrlB-1ntyA:
undetectable		 1wrlB-1ntyA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogy DIHEME CYTOCHROME C
NAPB MOLECULE:
NITRATE REDUCTASE
PERIPLASMIC NITRATE
REDUCTASE

(Rhodobacter
sphaeroides) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF03892
(NapB)
PF04879
(Molybdop_Fe4S4) 		4 PHE A 715
LEU B  21
PHE A 769
SER A 772
 None
 1.03A 1wrlB-1ogyA:
undetectable		 1wrlB-1ogyA:
7.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ovw ENDOGLUCANASE I

(Fusarium
oxysporum) 		PF00840
(Glyco_hydro_7) 		4 PHE A 386
VAL A 384
LEU A 136
PHE A 129
 None
 1.00A 1wrlB-1ovwA:
undetectable		 1wrlB-1ovwA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q2e EXOCELLOBIOHYDROLASE
I

(Trichoderma
reesei) 		PF00840
(Glyco_hydro_7) 		4 PHE A 418
VAL A 416
LEU A 136
PHE A 129
 None
 1.01A 1wrlB-1q2eA:
undetectable		 1wrlB-1q2eA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1upf URACIL
PHOSPHORIBOSYLTRANSF
ERASE

(Toxoplasma
gondii) 		no annotation 4 PHE D 192
VAL D 173
MET D 117
SER D 116
 None
 0.96A 1wrlB-1upfD:
undetectable		 1wrlB-1upfD:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1viw ALPHA-AMYLASE-INHIBI
TOR

(Phaseolus
vulgaris) 		PF00139
(Lectin_legB) 		4 PHE B  66
VAL B 135
LEU B 150
SER B  78
 None
 1.07A 1wrlB-1viwB:
undetectable		 1wrlB-1viwB:
16.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wrk TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES

(Homo sapiens) 		PF13833
(EF-hand_8) 		6 PHE A  27
VAL A  44
LEU A  48
PHE A  77
MET A  81
SER A  84
 TFP  A 204 (-4.4A)
None
TFP  A 202 (-4.1A)
None
TFP  A 202 ( 3.3A)
TFP  A 204 (-2.9A)
 0.40A 1wrlB-1wrkA:
17.7		 1wrlB-1wrkA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xf1 C5A PEPTIDASE

(Streptococcus
pyogenes) 		PF00082
(Peptidase_S8)
PF02225
(PA)
PF06280
(fn3_5)
PF13585
(CHU_C) 		4 PHE A 838
VAL A 866
PHE A 834
SER A 860
 None
 1.03A 1wrlB-1xf1A:
undetectable		 1wrlB-1xf1A:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3v CELLULASE

(Phanerochaete
chrysosporium) 		PF00840
(Glyco_hydro_7) 		4 PHE A 415
VAL A 413
LEU A 133
PHE A 126
 None
 0.92A 1wrlB-1z3vA:
undetectable		 1wrlB-1z3vA:
17.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zot CALMODULIN

(Homo sapiens) 		PF13499
(EF-hand_7) 		4 VAL B 108
LEU B 112
PHE B 141
MET B 145
 None
 0.61A 1wrlB-1zotB:
10.0		 1wrlB-1zotB:
38.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f2p CALMODULIN FUSED
WITH
CALMODULIN-BINDING
DOMAIN OF
CALCINEURIN

(Bos taurus) 		PF13499
(EF-hand_7) 		5 PHE A  19
VAL A  35
LEU A  39
PHE A  68
MET A  72
 None
 1.28A 1wrlB-2f2pA:
11.6		 1wrlB-2f2pA:
61.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gml RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE F

(Escherichia
coli) 		PF00849
(PseudoU_synth_2) 		4 PHE A 112
VAL A  74
LEU A 138
PHE A  84
 None
 1.00A 1wrlB-2gmlA:
undetectable		 1wrlB-2gmlA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gti REPLICASE
POLYPROTEIN 1AB

(Murine
coronavirus) 		PF06471
(NSP11) 		5 PHE A 260
VAL A 264
LEU A 278
MET A 237
SER A 235
 None
None
None
None
SO4  A 506 (-4.5A)
 0.91A 1wrlB-2gtiA:
undetectable		 1wrlB-2gtiA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gti REPLICASE
POLYPROTEIN 1AB

(Murine
coronavirus) 		PF06471
(NSP11) 		5 PHE A 260
VAL A 264
PHE A 249
MET A 237
SER A 235
 None
None
None
None
SO4  A 506 (-4.5A)
 0.99A 1wrlB-2gtiA:
undetectable		 1wrlB-2gtiA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h1c TRAFFICKING PROTEIN
B

(Neisseria
gonorrhoeae) 		PF01850
(PIN) 		4 PHE A 126
VAL A 118
LEU A   3
SER A  10
 None
None
MG  A 203 (-4.2A)
None
 0.99A 1wrlB-2h1cA:
undetectable		 1wrlB-2h1cA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3f GLYCOLIPID
TRANSFER-LIKE
PROTEIN

(Galdieria
sulphuraria) 		PF08718
(GLTP) 		4 PHE A 104
VAL A  42
LEU A  43
PHE A  35
 None
 1.02A 1wrlB-2i3fA:
undetectable		 1wrlB-2i3fA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ip2 PROBABLE
PHENAZINE-SPECIFIC
METHYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		4 LEU A 291
PHE A 146
MET A 150
SER A 153
 None
 1.08A 1wrlB-2ip2A:
undetectable		 1wrlB-2ip2A:
13.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2l1w CALMODULIN

(Glycine max) 		PF13499
(EF-hand_7) 		4 PHE A  92
VAL A 108
LEU A 112
MET A 124
 None
 1.01A 1wrlB-2l1wA:
9.8		 1wrlB-2l1wA:
50.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2lhh CALMODULIN

(Saccharomyces
cerevisiae) 		PF00036
(EF-hand_1)
PF13499
(EF-hand_7) 		4 PHE A  19
VAL A  35
LEU A  39
PHE A  68
 None
 1.05A 1wrlB-2lhhA:
7.2		 1wrlB-2lhhA:
36.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2n6a HUMAN
CALMODULIN/CONNEXIN-
36 PEPTIDE HYBRID

(Homo sapiens) 		PF13499
(EF-hand_7) 		4 PHE A  19
VAL A  35
LEU A  39
MET A  51
 None
 1.05A 1wrlB-2n6aA:
9.7		 1wrlB-2n6aA:
57.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o14 HYPOTHETICAL PROTEIN
YXIM

(Bacillus
subtilis) 		PF13472
(Lipase_GDSL_2) 		4 PHE A 123
VAL A  91
LEU A 150
MET A 114
 None
 1.05A 1wrlB-2o14A:
undetectable		 1wrlB-2o14A:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ohh TYPE A FLAVOPROTEIN
FPRA

(Methanothermobacter
thermautotrophicus) 		PF00258
(Flavodoxin_1)
PF00753
(Lactamase_B) 		4 PHE A  99
VAL A  76
LEU A  39
SER A  52
 None
 0.97A 1wrlB-2ohhA:
undetectable		 1wrlB-2ohhA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF06471
(NSP11) 		6 PHE A 232
VAL A 236
LEU A 250
PHE A 221
MET A 209
SER A 207
 None
 1.35A 1wrlB-2ozkA:
undetectable		 1wrlB-2ozkA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfl INOSITOL-1-MONOPHOSP
HATASE

(Escherichia
coli) 		PF00459
(Inositol_P) 		4 PHE A  92
VAL A  43
PHE A  99
MET A 120
 None
 0.95A 1wrlB-2qflA:
undetectable		 1wrlB-2qflA:
18.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rob CALMODULIN

(Glycine max) 		PF13499
(EF-hand_7) 		5 PHE A  92
VAL A 108
LEU A 112
PHE A 141
MET A 145
 None
 1.00A 1wrlB-2robA:
11.1		 1wrlB-2robA:
40.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		5 VAL G 922
LEU G 995
PHE G 946
MET G1006
SER G1005
 None
 1.48A 1wrlB-2uv8G:
undetectable		 1wrlB-2uv8G:
3.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2j CARBONIC
ANHYDRASE-RELATED
PROTEIN

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 PHE A 117
LEU A 206
PHE A 250
SER A 243
 None
 1.07A 1wrlB-2w2jA:
undetectable		 1wrlB-2w2jA:
14.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2w49 TROPONIN C, SKELETAL
MUSCLE

(Gallus gallus) 		PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		5 PHE 0  28
VAL 0  44
LEU 0  48
PHE 0  77
MET 0  81
 None
 1.19A 1wrlB-2w490:
13.5		 1wrlB-2w490:
64.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yg1 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Heterobasidion
annosum) 		PF00840
(Glyco_hydro_7) 		4 PHE A 426
VAL A 424
LEU A 138
PHE A 131
 None
 0.90A 1wrlB-2yg1A:
undetectable		 1wrlB-2yg1A:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yky BETA-TRANSAMINASE

(Mesorhizobium
sp. LUK) 		PF00202
(Aminotran_3) 		4 PHE A 141
VAL A 139
PHE A 288
SER A 258
 None
 1.01A 1wrlB-2ykyA:
undetectable		 1wrlB-2ykyA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Bifidobacterium
longum) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		4 VAL A1163
LEU A1161
PHE A1109
SER A1099
 None
 0.92A 1wrlB-2zxqA:
undetectable		 1wrlB-2zxqA:
5.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayh DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC8
DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC9

(Schizosaccharomyces
pombe) 		PF03874
(RNA_pol_Rpb4)
PF03876
(SHS2_Rpb7-N)
PF08292
(RNA_pol_Rbc25) 		4 PHE B   2
VAL A  16
LEU A  20
SER A  58
 None
 0.81A 1wrlB-3ayhB:
undetectable		 1wrlB-3ayhB:
21.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b32 CALMODULIN

(Rattus
norvegicus) 		PF13499
(EF-hand_7) 		5 PHE A  19
VAL A  35
LEU A  39
PHE A  68
MET A  72
 None
 1.47A 1wrlB-3b32A:
11.4		 1wrlB-3b32A:
59.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3chv PROKARYOTIC DOMAIN
OF UNKNOWN FUNCTION
(DUF849) WITH A TIM
BARREL FOLD

(Ruegeria
pomeroyi) 		PF05853
(BKACE) 		4 PHE A 149
VAL A 175
PHE A 118
SER A  18
 None
 1.06A 1wrlB-3chvA:
undetectable		 1wrlB-3chvA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d46 PUTATIVE GALACTONATE
DEHYDRATASE

(Salmonella
enterica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 PHE A 389
VAL A 156
LEU A 160
SER A 348
 None
 1.05A 1wrlB-3d46A:
undetectable		 1wrlB-3d46A:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dh3 RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE F

(Escherichia
coli) 		PF00849
(PseudoU_synth_2)
PF01479
(S4) 		4 PHE A 177
VAL A 139
LEU A 203
PHE A 149
 None
 0.96A 1wrlB-3dh3A:
undetectable		 1wrlB-3dh3A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ez9 PARA

(Salmonella
enterica) 		PF13614
(AAA_31) 		4 VAL A  47
LEU A  53
PHE A  72
MET A  65
 None
 0.90A 1wrlB-3ez9A:
undetectable		 1wrlB-3ez9A:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fa5 PROTEIN OF UNKNOWN
FUNCTION (DUF849)

(Paracoccus
denitrificans) 		PF05853
(BKACE) 		4 PHE A 149
VAL A 175
PHE A 118
SER A  18
 None
 1.04A 1wrlB-3fa5A:
undetectable		 1wrlB-3fa5A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ggg PREPHENATE
DEHYDROGENASE

(Aquifex
aeolicus) 		no annotation 4 VAL D 186
LEU D 185
PHE D  45
SER D  52
 None
 1.08A 1wrlB-3gggD:
undetectable		 1wrlB-3gggD:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3guv SITE-SPECIFIC
RECOMBINASE,
RESOLVASE FAMILY
PROTEIN

(Streptococcus
pneumoniae) 		PF00239
(Resolvase) 		4 PHE A  88
VAL A  82
PHE A  63
MET A  67
 None
 0.95A 1wrlB-3guvA:
undetectable		 1wrlB-3guvA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4x PROLIFERATING CELL
NUCLEAR ANTIGEN

(Saccharomyces
cerevisiae) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 VAL A  23
LEU A  72
PHE A 248
SER A 220
 None
 0.92A 1wrlB-3k4xA:
undetectable		 1wrlB-3k4xA:
7.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN

(Homo sapiens) 		PF01409
(tRNA-synt_2d) 		4 VAL A 390
LEU A 387
PHE A 238
SER A 332
 None
 0.97A 1wrlB-3l4gA:
undetectable		 1wrlB-3l4gA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o01 CELL INVASION
PROTEIN SIPD

(Salmonella
enterica) 		PF06511
(IpaD) 		4 PHE A 109
VAL A 138
LEU A  87
SER A 333
 None
 0.94A 1wrlB-3o01A:
undetectable		 1wrlB-3o01A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o2y PROSTAGLANDIN-H2
D-ISOMERASE

(Homo sapiens) 		PF00061
(Lipocalin) 		4 PHE A  39
VAL A  69
LEU A  79
PHE A  34
 None
None
PLM  A 201 (-4.8A)
None
 1.00A 1wrlB-3o2yA:
undetectable		 1wrlB-3o2yA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppc 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Candida
albicans) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		4 PHE A 275
VAL A 258
LEU A 262
PHE A 277
 None
 1.06A 1wrlB-3ppcA:
undetectable		 1wrlB-3ppcA:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3twk FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE 1

(Arabidopsis
thaliana) 		PF01149
(Fapy_DNA_glyco)
PF06831
(H2TH) 		4 PHE A 110
VAL A 112
LEU A 114
SER A  95
 None
 1.07A 1wrlB-3twkA:
undetectable		 1wrlB-3twkA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0k RCAMP

(Entacmaea
quadricolor) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		5 PHE A 313
VAL A 329
LEU A 333
PHE A 362
MET A 366
 None
 1.25A 1wrlB-3u0kA:
10.4		 1wrlB-3u0kA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0k RCAMP

(Entacmaea
quadricolor) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		4 VAL A 402
LEU A 406
PHE A 435
MET A 439
 None
 0.60A 1wrlB-3u0kA:
10.4		 1wrlB-3u0kA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vyw MNMC2

(Aquifex
aeolicus) 		PF05430
(Methyltransf_30) 		4 PHE A 279
VAL A 303
LEU A 300
SER A 196
 None
 1.08A 1wrlB-3vywA:
undetectable		 1wrlB-3vywA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5n PUTATIVE
RHAMNOSIDASE

(Streptomyces
avermitilis) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		4 LEU A 625
PHE A 598
MET A 655
SER A 657
 None
RAM  A1204 (-3.6A)
None
None
 0.84A 1wrlB-3w5nA:
undetectable		 1wrlB-3w5nA:
7.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wy7 8-AMINO-7-OXONONANOA
TE SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00155
(Aminotran_1_2) 		4 VAL A 199
LEU A 197
PHE A 174
SER A 146
 None
 0.87A 1wrlB-3wy7A:
undetectable		 1wrlB-3wy7A:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4buc UDP-N-ACETYLMURAMOYL
ALANINE--D-GLUTAMATE
LIGASE

(Thermotoga
maritima) 		PF08245
(Mur_ligase_M) 		4 PHE A 442
PHE A 403
MET A 407
SER A 410
 None
None
PO4  A1005 (-4.5A)
None
 0.74A 1wrlB-4bucA:
undetectable		 1wrlB-4bucA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ce7 UNSATURATED
3S-RHAMNOGLYCURONYL
HYDROLASE

(Nonlabens
ulvanivorans) 		PF07470
(Glyco_hydro_88) 		4 PHE A 192
VAL A 224
LEU A 228
SER A 254
 None
 0.89A 1wrlB-4ce7A:
undetectable		 1wrlB-4ce7A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ddq DNA GYRASE SUBUNIT A

(Bacillus
subtilis) 		PF00521
(DNA_topoisoIV) 		4 VAL A 268
LEU A 273
MET A 301
SER A 296
 None
 1.04A 1wrlB-4ddqA:
undetectable		 1wrlB-4ddqA:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f8a POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY H
MEMBER 1

(Mus musculus) 		PF00027
(cNMP_binding) 		4 PHE A 620
VAL A 643
LEU A 697
PHE A 582
 None
 0.93A 1wrlB-4f8aA:
undetectable		 1wrlB-4f8aA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4faj PRGZ

(Enterococcus
faecalis) 		PF00496
(SBP_bac_5) 		4 PHE A 321
VAL A 527
LEU A 521
SER A 487
 None
 0.99A 1wrlB-4fajA:
undetectable		 1wrlB-4fajA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4haq GH7 FAMILY PROTEIN

(Limnoria
quadripunctata) 		PF00840
(Glyco_hydro_7) 		4 PHE A 441
VAL A 439
LEU A 157
PHE A 150
 None
 0.98A 1wrlB-4haqA:
undetectable		 1wrlB-4haqA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ixk FERRITIN

(Pseudo-nitzschia
multiseries) 		PF00210
(Ferritin) 		4 VAL A 141
LEU A 138
PHE A  29
MET A  41
 None
 1.07A 1wrlB-4ixkA:
undetectable		 1wrlB-4ixkA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mco TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT

(Rhodoferax
ferrireducens) 		PF03480
(DctP) 		4 PHE A  54
VAL A 267
PHE A  68
MET A  66
 None
 1.06A 1wrlB-4mcoA:
undetectable		 1wrlB-4mcoA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4orx PROSTAGLANDIN-H2
D-ISOMERASE

(Homo sapiens) 		PF00061
(Lipocalin) 		4 PHE A  39
VAL A  69
LEU A  79
PHE A  34
 None
 0.97A 1wrlB-4orxA:
undetectable		 1wrlB-4orxA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ri1 UDP-4-AMINO-4,6-DIDE
OXY-N-ACETYL-BETA-L-
ALTROSAMINE
N-ACETYLTRANSFERASE

(Helicobacter
pylori) 		PF13420
(Acetyltransf_4) 		4 PHE A  15
VAL A  26
PHE A  52
SER A  41
 None
None
ACT  A1302 (-2.7A)
None
 1.03A 1wrlB-4ri1A:
undetectable		 1wrlB-4ri1A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2

(Pisum sativum) 		PF00223
(PsaA_PsaB) 		4 VAL A 551
LEU A 554
MET B 662
SER B 666
 None
CLA  B9023 (-4.5A)
CLA  B9023 ( 3.3A)
PQN  B5002 (-3.2A)
 1.04A 1wrlB-4rkuA:
undetectable		 1wrlB-4rkuA:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rl5 EXOCYST COMPLEX
COMPONENT EXO70A1

(Arabidopsis
thaliana) 		PF03081
(Exo70) 		4 PHE A 383
VAL A 387
LEU A 404
SER A 481
 None
 1.06A 1wrlB-4rl5A:
undetectable		 1wrlB-4rl5A:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1t URIDYLATE-SPECIFIC
ENDORIBONUCLEASE

(Human
coronavirus
229E) 		PF06471
(NSP11) 		6 PHE A 233
VAL A 237
LEU A 251
PHE A 222
MET A 210
SER A 208
 None
 1.26A 1wrlB-4s1tA:
undetectable		 1wrlB-4s1tA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3p 4-ALPHA-GLUCANOTRANS
FERASE

(Escherichia
coli) 		PF02446
(Glyco_hydro_77) 		4 VAL A 493
LEU A 445
MET A 453
SER A 452
 None
 1.07A 1wrlB-4s3pA:
undetectable		 1wrlB-4s3pA:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tr6 DNA POLYMERASE III
SUBUNIT BETA

(Bacillus
subtilis) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		4 PHE A  84
VAL A  88
LEU A  91
PHE A  46
 None
 1.03A 1wrlB-4tr6A:
undetectable		 1wrlB-4tr6A:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvs TORSIN-1A-INTERACTIN
G PROTEIN 1

(Homo sapiens) 		PF05609
(LAP1C) 		4 VAL A 509
LEU A 412
PHE A 368
MET A 372
 None
 1.00A 1wrlB-4tvsA:
undetectable		 1wrlB-4tvsA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yud RNA-BINDING PROTEIN
39

(Homo sapiens) 		PF00076
(RRM_1) 		4 VAL A 218
LEU A 219
MET A 184
SER A 186
 None
 1.04A 1wrlB-4yudA:
undetectable		 1wrlB-4yudA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8f HUMAN SAFFOLD
VIRUS-3 VP1

(Cardiovirus B) 		no annotation 4 VAL A 239
LEU A  46
PHE A 188
MET A 175
 None
 0.92A 1wrlB-5a8fA:
undetectable		 1wrlB-5a8fA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3h PROTEIN SCARECROW

(Arabidopsis
thaliana) 		PF03514
(GRAS) 		4 VAL A 488
LEU A 406
PHE A 600
MET A 595
 None
 1.02A 1wrlB-5b3hA:
undetectable		 1wrlB-5b3hA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cfc VP1

(Cardiovirus B) 		no annotation 4 VAL A 239
LEU A  46
PHE A 188
MET A 175
 None
 0.92A 1wrlB-5cfcA:
undetectable		 1wrlB-5cfcA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ep1 PUTATIVE REPRESSOR
PROTEIN LUXO

(Photobacterium
angustum) 		PF00158
(Sigma54_activat) 		4 VAL A 359
PHE A 142
MET A 149
SER A 146
 ACT  A 404 ( 4.9A)
ACT  A 404 (-4.8A)
None
None
 1.04A 1wrlB-5ep1A:
undetectable		 1wrlB-5ep1A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyt ADENYLOSUCCINATE
LYASE

(Schistosoma
mansoni) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		4 LEU A 306
PHE A  24
MET A  20
SER A  17
 None
 0.71A 1wrlB-5eytA:
undetectable		 1wrlB-5eytA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fv0 ESSC

(Geobacillus
thermodenitrificans) 		PF01580
(FtsK_SpoIIIE) 		4 VAL A1410
LEU A1281
MET A1398
SER A1402
 None
 0.82A 1wrlB-5fv0A:
undetectable		 1wrlB-5fv0A:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjt SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5

(Arabidopsis
thaliana) 		PF00149
(Metallophos)
PF00515
(TPR_1)
PF08321
(PPP5)
PF13431
(TPR_17) 		4 PHE A 301
VAL A 305
LEU A 309
PHE A 321
 None
 0.98A 1wrlB-5jjtA:
undetectable		 1wrlB-5jjtA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k7l POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY H
MEMBER 1

(Rattus
norvegicus) 		PF00027
(cNMP_binding)
PF00520
(Ion_trans)
PF13426
(PAS_9) 		4 PHE A 593
VAL A 616
LEU A 670
PHE A 555
 None
 0.86A 1wrlB-5k7lA:
undetectable		 1wrlB-5k7lA:
7.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kc8 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo sapiens) 		PF01094
(ANF_receptor) 		4 PHE A  44
VAL A 331
LEU A 334
SER A  25
 None
 0.86A 1wrlB-5kc8A:
undetectable		 1wrlB-5kc8A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2e GLUTAMATE RECEPTOR
IONOTROPIC,
DELTA-2,GLUTAMATE
RECEPTOR IONOTROPIC,
DELTA-2

(Rattus
norvegicus) 		PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		4 PHE A  44
VAL A 331
LEU A 334
SER A  25
 None
 0.81A 1wrlB-5l2eA:
undetectable		 1wrlB-5l2eA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ly8 TAIL COMPONENT

(Lactobacillus
phage J-1) 		no annotation 4 PHE A 129
VAL A 139
LEU A 157
MET A 152
 None
 1.08A 1wrlB-5ly8A:
undetectable		 1wrlB-5ly8A:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o33 KALIRIN

(Rattus
norvegicus) 		PF00621
(RhoGEF) 		4 PHE B1296
LEU B1241
PHE B1321
MET B1398
 None
 0.98A 1wrlB-5o33B:
undetectable		 1wrlB-5o33B:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5d GLUCANASE

(Trichoderma
atroviride) 		no annotation 4 PHE A 418
VAL A 416
LEU A 136
PHE A 129
 None
 1.02A 1wrlB-5o5dA:
undetectable		 1wrlB-5o5dA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oe5 ANTHRANILATE--COA
LIGASE

(Pseudomonas
aeruginosa) 		PF00501
(AMP-binding) 		4 VAL A 309
LEU A 327
PHE A 252
SER A 223
 3UK  A 900 ( 4.1A)
None
None
None
 1.07A 1wrlB-5oe5A:
undetectable		 1wrlB-5oe5A:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t88 PROLYL ENDOPEPTIDASE

(Pyrococcus
furiosus) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		4 PHE A 399
PHE A 413
MET A 411
SER A 324
 None
 0.94A 1wrlB-5t88A:
undetectable		 1wrlB-5t88A:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj3 ALKALINE PHOSPHATASE
PAFA

(Elizabethkingia
meningoseptica) 		PF01663
(Phosphodiest) 		5 PHE A 296
VAL A  32
LEU A 346
PHE A  87
SER A 350
 None
 1.43A 1wrlB-5tj3A:
undetectable		 1wrlB-5tj3A:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v4l ADENYLOSUCCINATE
LYASE

(Cryptococcus
neoformans) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		4 LEU A 304
PHE A  21
MET A  17
SER A  14
 None
 0.84A 1wrlB-5v4lA:
undetectable		 1wrlB-5v4lA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8j CYCLIC GMP-AMP
SYNTHASE

(Homo sapiens) 		PF03281
(Mab-21) 		4 PHE A 519
VAL A 168
LEU A 172
PHE A 464
 None
 1.05A 1wrlB-5v8jA:
undetectable		 1wrlB-5v8jA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0a GLUCANASE

(Trichoderma
harzianum) 		no annotation 4 PHE A 359
VAL A 357
LEU A 137
PHE A 130
 PHE  A 359 ( 1.3A)
VAL  A 357 ( 0.6A)
LEU  A 137 ( 0.6A)
PHE  A 130 ( 1.3A)
 1.00A 1wrlB-5w0aA:
undetectable		 1wrlB-5w0aA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w11 GLUCANASE

(Thermothelomyces
thermophila) 		no annotation 4 PHE A 422
VAL A 420
LEU A 137
PHE A 130
 None
 0.92A 1wrlB-5w11A:
undetectable		 1wrlB-5w11A:
17.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w88 TROPONIN C, TROPONIN
I

(Homo sapiens) 		PF00992
(Troponin)
PF13833
(EF-hand_8) 		5 PHE A  27
VAL A  44
LEU A  48
PHE A  77
MET A  81
 9XG  A 201 (-3.8A)
9XG  A 201 ( 4.2A)
9XG  A 201 ( 4.8A)
9XG  A 201 (-3.8A)
9XG  A 201 ( 4.6A)
 1.36A 1wrlB-5w88A:
12.2		 1wrlB-5w88A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w88 TROPONIN C, TROPONIN
I

(Homo sapiens) 		PF00992
(Troponin)
PF13833
(EF-hand_8) 		5 PHE A  27
VAL A  44
PHE A  77
MET A  81
SER A  84
 9XG  A 201 (-3.8A)
9XG  A 201 ( 4.2A)
9XG  A 201 (-3.8A)
9XG  A 201 ( 4.6A)
9XG  A 201 ( 4.3A)
 1.48A 1wrlB-5w88A:
12.2		 1wrlB-5w88A:
100.00