SIMILAR PATTERNS OF AMINO ACIDS FOR 1WOP_A_FFOA2888_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		5 LEU A 997
GLU A 993
LEU A 994
ILE A 918
LEU A 925
 None
 1.12A 1wopA-1g8xA:
0.0		 1wopA-1g8xA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1grj GREA PROTEIN

(Escherichia
coli) 		PF01272
(GreA_GreB)
PF03449
(GreA_GreB_N) 		5 LEU A  21
GLU A  17
ILE A  62
ILE A   4
LEU A  69
 None
 0.88A 1wopA-1grjA:
undetectable		 1wopA-1grjA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9o ALASERPIN

(Manduca sexta) 		PF00079
(Serpin) 		5 LEU I  69
LEU I  73
ILE I 301
ILE I 178
LEU I  51
 None
 1.18A 1wopA-1k9oI:
0.0		 1wopA-1k9oI:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kon PROTEIN YEBC

(Escherichia
coli) 		PF01709
(Transcrip_reg) 		5 LEU A  32
ILE A  28
ILE A  86
GLU A 100
LEU A 102
 None
 1.23A 1wopA-1konA:
2.5		 1wopA-1konA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l6w FRUCTOSE-6-PHOSPHATE
ALDOLASE 1

(Escherichia
coli) 		PF00923
(TAL_FSA) 		5 LEU A  39
LEU A  43
ILE A  32
GLU A   2
LEU A  56
 None
 1.16A 1wopA-1l6wA:
0.0		 1wopA-1l6wA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogy PERIPLASMIC NITRATE
REDUCTASE

(Rhodobacter
sphaeroides) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 LEU A 367
LEU A 364
ILE A 248
ILE A 318
LEU A 241
 None
 1.25A 1wopA-1ogyA:
0.0		 1wopA-1ogyA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6z CHIMERA OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND ARGONAUTE 2

(Escherichia
coli;
Drosophila
melanogaster) 		no annotation 5 LEU P 191
LEU P 194
ILE P 160
GLU P 152
LEU P 150
 None
None
None
MAL  P 727 (-3.6A)
None
 1.24A 1wopA-1r6zP:
0.0		 1wopA-1r6zP:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s0p ADENYLYL
CYCLASE-ASSOCIATED
PROTEIN

(Dictyostelium
discoideum) 		PF01213
(CAP_N) 		5 LEU A 116
GLU A  91
LEU A  94
ILE A 113
LEU A 213
 None
 1.18A 1wopA-1s0pA:
undetectable		 1wopA-1s0pA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5b 3-ISOPROPYLMALATE
DEHYDROGENASE

(Bacillus
coagulans) 		PF00180
(Iso_dh) 		5 LEU A 325
GLU A  16
ILE A  13
LEU A 294
MET A 261
 None
 1.03A 1wopA-1v5bA:
0.0		 1wopA-1v5bA:
24.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wop AMINOMETHYLTRANSFERA
SE

(Thermotoga
maritima) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		10 LEU A  55
GLU A 106
LEU A 108
ILE A 137
GLU A 160
LYS A 173
ILE A 175
GLU A 180
LEU A 182
MET A 197
 FFO  A2888 (-3.4A)
FFO  A2888 (-2.9A)
FFO  A2888 (-4.2A)
None
FFO  A2888 (-2.8A)
FFO  A2888 (-2.6A)
FFO  A2888 (-4.7A)
FFO  A2888 (-3.7A)
FFO  A2888 (-4.2A)
FFO  A2888 (-3.5A)
 0.00A 1wopA-1wopA:
65.4		 1wopA-1wopA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xb7 STEROID HORMONE
RECEPTOR ERR1

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 348
ILE A 438
GLU A 453
GLU A 449
LEU A 447
 None
 1.14A 1wopA-1xb7A:
undetectable		 1wopA-1xb7A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cu2 PUTATIVE
MANNOSE-1-PHOSPHATE
GUANYLYL TRANSFERASE

(Thermus
thermophilus) 		PF00483
(NTP_transferase) 		5 LEU A  56
ILE A  73
GLU A 116
GLU A  43
LEU A  45
 None
 1.12A 1wopA-2cu2A:
undetectable		 1wopA-2cu2A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9z CHEMOTAXIS PROTEIN
CHEC

(Thermotoga
maritima) 		PF04509
(CheC) 		5 LEU A 129
LEU A 125
ILE A 197
GLU A 169
MET A 187
 None
 1.11A 1wopA-2f9zA:
undetectable		 1wopA-2f9zA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iv2 FORMATE
DEHYDROGENASE H

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 LEU X 318
LEU X 315
ILE X 234
ILE X 270
LEU X 227
 None
 1.17A 1wopA-2iv2X:
undetectable		 1wopA-2iv2X:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA

(Homo sapiens) 		PF00899
(ThiF)
PF08825
(E2_bind)
PF13416
(SBP_bac_8) 		5 LEU B1193
LEU B1196
ILE B1162
GLU B1154
LEU B1152
 None
 1.24A 1wopA-2nvuB:
undetectable		 1wopA-2nvuB:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8d PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE 2

(Bacillus
subtilis) 		PF00884
(Sulfatase) 		5 LEU A 533
LEU A 534
ILE A 465
GLU A 305
LEU A 332
 None
 1.25A 1wopA-2w8dA:
undetectable		 1wopA-2w8dA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2d CD180 ANTIGEN

(Homo sapiens) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 LEU A 154
LEU A 130
GLU A  94
GLU A 118
LEU A 121
 None
 1.24A 1wopA-3b2dA:
undetectable		 1wopA-3b2dA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bsx PUMILIO HOMOLOG 1

(Homo sapiens) 		PF00806
(PUF) 		5 LEU A1036
LEU A1029
ILE A1046
GLU A 979
LEU A1014
 None
 1.12A 1wopA-3bsxA:
undetectable		 1wopA-3bsxA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csg MALTOSE-BINDING
PROTEIN MONOBODY YS1
FUSION

(Escherichia
coli) 		PF00041
(fn3)
PF13416
(SBP_bac_8) 		5 LEU A 192
LEU A 195
ILE A 161
GLU A 153
LEU A 151
 None
 1.12A 1wopA-3csgA:
undetectable		 1wopA-3csgA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dm0 MALTOSE-BINDING
PERIPLASMIC PROTEIN
FUSED WITH RACK1

(Escherichia
coli;
Arabidopsis
thaliana) 		PF00400
(WD40)
PF01547
(SBP_bac_1) 		5 LEU A 192
LEU A 195
ILE A 161
GLU A 153
LEU A 151
 None
None
None
EDO  A 401 (-3.4A)
None
 1.23A 1wopA-3dm0A:
undetectable		 1wopA-3dm0A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e53 FATTY-ACID-COA
LIGASE FADD28

(Mycobacterium
tuberculosis) 		PF00501
(AMP-binding) 		5 LEU A  80
LEU A   6
ILE A 229
ILE A 206
LEU A 234
 None
 1.23A 1wopA-3e53A:
undetectable		 1wopA-3e53A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eck PROTEIN
(HOMOPROTOCATECHUATE
2,3-DIOXYGENASE)

(Brevibacterium
fuscum) 		PF00903
(Glyoxalase) 		5 GLU A 149
LEU A 150
ILE A 228
GLU A  46
LEU A  41
 None
 1.24A 1wopA-3eckA:
undetectable		 1wopA-3eckA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehs FUSION PROTEIN OF
CRFR1 EXTRACELLULAR
DOMAIN AND MBP

(Escherichia
coli;
Homo sapiens) 		PF02793
(HRM)
PF13416
(SBP_bac_8) 		5 LEU A-157
LEU A-154
ILE A-188
GLU A-196
LEU A-198
 None
None
None
MAL  A 126 (-3.8A)
None
 1.22A 1wopA-3ehsA:
undetectable		 1wopA-3ehsA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli) 		PF01134
(GIDA)
PF13932
(GIDA_assoc) 		5 LEU A 448
LEU A  66
ILE A 451
GLU A 358
LEU A 389
 None
 1.25A 1wopA-3g05A:
undetectable		 1wopA-3g05A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gra TRANSCRIPTIONAL
REGULATOR, ARAC
FAMILY

(Pseudomonas
putida) 		PF01965
(DJ-1_PfpI) 		5 LEU A 117
GLU A 113
LEU A 114
GLU A  82
LEU A  37
 None
SO4  A   4 ( 3.2A)
None
None
EDO  A   1 ( 4.6A)
 1.15A 1wopA-3graA:
undetectable		 1wopA-3graA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0r ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B

(Aquifex
aeolicus) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N) 		5 LEU B 355
LEU B 351
ILE B 362
GLU B 370
LEU B 372
 None
 1.06A 1wopA-3h0rB:
undetectable		 1wopA-3h0rB:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3d MATERNAL PROTEIN
PUMILIO

(Drosophila
melanogaster) 		PF00806
(PUF) 		5 LEU X 208
LEU X 201
ILE X 218
GLU X 151
LEU X 186
 None
 1.05A 1wopA-3h3dX:
undetectable		 1wopA-3h3dX:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00109
(ketoacyl-synt)
PF01648
(ACPS)
PF02801
(Ketoacyl-synt_C) 		5 LEU A 908
LEU A 909
ILE A 823
ILE A 721
LEU A 696
 None
 1.25A 1wopA-3hmjA:
undetectable		 1wopA-3hmjA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hur ALANINE RACEMASE

(Oenococcus oeni) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 LEU A 377
LEU A  15
ILE A 381
ILE A  64
LEU A  50
 None
 1.21A 1wopA-3hurA:
1.4		 1wopA-3hurA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i7a PUTATIVE
METAL-DEPENDENT
PHOSPHOHYDROLASE

(Shewanella
amazonensis) 		PF08668
(HDOD) 		5 LEU A  20
LEU A  11
ILE A 191
ILE A 177
LEU A 183
 None
 1.16A 1wopA-3i7aA:
undetectable		 1wopA-3i7aA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ivp PUTATIVE
TRANSPOSON-RELATED
DNA-BINDING PROTEIN

(Clostridioides
difficile) 		PF01381
(HTH_3) 		5 LEU A  60
LEU A  64
ILE A  35
GLU A  29
LEU A  26
 None
 1.20A 1wopA-3ivpA:
undetectable		 1wopA-3ivpA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j97 VESICLE-FUSING
ATPASE

(Cricetulus
griseus) 		PF00004
(AAA)
PF02359
(CDC48_N)
PF02933
(CDC48_2) 		5 LEU A 541
LEU A 552
ILE A 665
GLU A 522
LEU A 518
 None
 1.25A 1wopA-3j97A:
undetectable		 1wopA-3j97A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o3u MALTOSE-BINDING
PERIPLASMIC PROTEIN,
ADVANCED
GLYCOSYLATION END
PRODUCT-SPECIFIC
RECEPTOR

(Escherichia
coli;
Homo sapiens) 		PF08205
(C2-set_2)
PF13416
(SBP_bac_8) 		5 LEU N 192
LEU N 195
ILE N 161
GLU N 153
LEU N 151
 None
None
None
MLR  N2001 (-3.2A)
None
 1.24A 1wopA-3o3uN:
undetectable		 1wopA-3o3uN:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
MYELIN PROTEIN P0

(Escherichia
coli;
Homo sapiens) 		PF07686
(V-set)
PF13416
(SBP_bac_8) 		5 LEU A 192
LEU A 195
ILE A 161
GLU A 153
LEU A 151
 None
None
None
MAL  A1122 (-3.6A)
None
 1.17A 1wopA-3oaiA:
undetectable		 1wopA-3oaiA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogz UDP-SUGAR
PYROPHOSPHORYLASE

(Leishmania
major) 		PF01704
(UDPGP) 		5 LEU A  21
GLU A  15
LEU A  16
ILE A  63
LEU A  48
 None
 1.16A 1wopA-3ogzA:
undetectable		 1wopA-3ogzA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3osr MALTOSE-BINDING
PERIPLASMIC
PROTEIN,GREEN
FLUORESCENT PROTEIN

(Escherichia
coli;
Aequorea
victoria) 		PF01353
(GFP)
PF01547
(SBP_bac_1) 		5 LEU A 192
LEU A 195
ILE A 161
GLU A 153
LEU A 151
 None
None
None
MAL  A 700 (-3.6A)
None
 1.24A 1wopA-3osrA:
undetectable		 1wopA-3osrA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozb METHYLTHIOADENOSINE
PHOSPHORYLASE

(Pseudomonas
aeruginosa) 		PF01048
(PNP_UDP_1) 		5 LEU A  64
LEU A  87
ILE A  21
ILE A 141
LEU A 213
 None
 1.17A 1wopA-3ozbA:
undetectable		 1wopA-3ozbA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdi NITROGENASE MOFE
COFACTOR
BIOSYNTHESIS PROTEIN
NIFE

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro) 		5 LEU A 415
LEU A 438
ILE A 398
LEU A 346
MET A 348
 None
 1.01A 1wopA-3pdiA:
undetectable		 1wopA-3pdiA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pjx CYCLIC DIMERIC GMP
BINDING PROTEIN

(Pseudomonas
fluorescens) 		PF00563
(EAL)
PF00990
(GGDEF) 		5 LEU A 557
LEU A 577
ILE A 587
GLU A 617
LEU A 580
 EDO  A   3 (-4.5A)
None
None
None
None
 1.25A 1wopA-3pjxA:
2.3		 1wopA-3pjxA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppo GLYCINE
BETAINE/CARNITINE/CH
OLINE-BINDING
PROTEIN

(Bacillus
subtilis) 		PF04069
(OpuAC) 		5 LEU A  61
GLU A 257
LEU A 258
ILE A  34
LEU A 252
 None
 1.24A 1wopA-3ppoA:
undetectable		 1wopA-3ppoA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3py7 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PAXILLIN
LD1,PROTEIN E6
CHIMERA

(Escherichia
coli;
Homo sapiens;
Deltapapillomavirus
4) 		PF00518
(E6)
PF01547
(SBP_bac_1) 		5 LEU A 193
LEU A 196
ILE A 162
GLU A 154
LEU A 152
 None
None
None
MLR  A 701 (-3.2A)
None
 1.21A 1wopA-3py7A:
undetectable		 1wopA-3py7A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rbn DNA MISMATCH REPAIR
PROTEIN MLH1

(Homo sapiens) 		PF16413
(Mlh1_C) 		5 LEU A  97
LEU A 209
GLU A 162
LEU A 155
MET A 154
 None
 1.23A 1wopA-3rbnA:
undetectable		 1wopA-3rbnA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1h 3-ISOPROPYLMALATE
DEHYDROGENASE

(Bacillus sp.
(in: Bacteria)) 		PF00180
(Iso_dh) 		5 LEU A 325
GLU A  16
ILE A  13
LEU A 294
MET A 261
 None
 1.05A 1wopA-3u1hA:
undetectable		 1wopA-3u1hA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE

(Escherichia
coli;
Archaeoglobus
fulgidus) 		PF13416
(SBP_bac_8) 		5 LEU A 192
LEU A 195
ILE A 161
GLU A 153
LEU A 151
 None
 1.20A 1wopA-3waiA:
undetectable		 1wopA-3waiA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wpe TOLL-LIKE RECEPTOR 9

(Bos taurus) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A  69
LEU A  93
ILE A  74
GLU A 114
MET A 111
 None
 1.09A 1wopA-3wpeA:
undetectable		 1wopA-3wpeA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zpj TON_1535

(Thermococcus
onnurineus) 		no annotation 5 LEU A 289
GLU A 292
GLU A 347
ILE A 344
GLU A 314
 None
 1.19A 1wopA-3zpjA:
undetectable		 1wopA-3zpjA:
25.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ano ESSB

(Geobacillus
thermodenitrificans) 		PF10140
(YukC) 		5 LEU A   8
LEU A  12
ILE A 106
GLU A  40
LEU A 131
 None
 1.10A 1wopA-4anoA:
undetectable		 1wopA-4anoA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bg5 BBA65

(Borreliella
burgdorferi) 		PF05714
(Borrelia_lipo_1) 		5 LEU A 227
LEU A 224
ILE A 160
GLU A 173
LEU A 167
 None
 1.07A 1wopA-4bg5A:
undetectable		 1wopA-4bg5A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA

(Escherichia
coli) 		PF01547
(SBP_bac_1)
PF13354
(Beta-lactamase2) 		5 LEU A 192
LEU A 195
ILE A 161
GLU A 153
LEU A 151
 None
 1.06A 1wopA-4dxbA:
0.6		 1wopA-4dxbA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4edq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MYOSIN-BINDI
NG PROTEIN C,
CARDIAC-TYPE
CHIMERIC PROTEIN

(Escherichia
coli;
Mus musculus) 		PF07679
(I-set)
PF13416
(SBP_bac_8) 		5 LEU A 193
LEU A 196
ILE A 162
GLU A 154
LEU A 152
 None
None
None
MLR  A 500 (-3.0A)
None
 1.25A 1wopA-4edqA:
undetectable		 1wopA-4edqA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4giz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UBIQUITIN LIGASE
EA6P: CHIMERIC
PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF01547
(SBP_bac_1) 		5 LEU A 193
LEU A 196
ILE A 162
GLU A 154
LEU A 152
 None
None
None
CEY  A 400 (-3.1A)
None
 1.25A 1wopA-4gizA:
undetectable		 1wopA-4gizA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1g MALTOSE BINDING
PROTEIN-CAKAR3 MOTOR
DOMAIN FUSION
PROTEIN

(Escherichia
coli;
Candida
albicans) 		PF00225
(Kinesin)
PF13416
(SBP_bac_8) 		5 LEU A-178
LEU A-175
ILE A-209
GLU A-217
LEU A-219
 None
None
None
MTT  A 701 (-3.2A)
None
 1.25A 1wopA-4h1gA:
undetectable		 1wopA-4h1gA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ikm MALTOSE-BINDING
PERIPLASMIC PROTEIN,
CASPASE RECRUITMENT
DOMAIN-CONTAINING
PROTEIN 8

(Escherichia
coli;
Homo sapiens) 		PF00619
(CARD)
PF13416
(SBP_bac_8) 		5 LEU A 193
LEU A 196
ILE A 162
GLU A 154
LEU A 152
 None
None
None
MAL  A 501 (-3.6A)
None
 1.24A 1wopA-4ikmA:
undetectable		 1wopA-4ikmA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4keg MALTOSE-BINDING
PERIPLASMIC/PALATE
LUNG AND NASAL
EPITHELIUM CLONE
FUSION PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF01273
(LBP_BPI_CETP)
PF13416
(SBP_bac_8) 		5 LEU A 192
LEU A 195
ILE A 161
GLU A 153
LEU A 151
 None
 1.19A 1wopA-4kegA:
undetectable		 1wopA-4kegA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4log MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN
AND NR2E3 PROTEIN
CHIMERIC CONSTRUCT

(Escherichia
coli;
Homo sapiens) 		PF00104
(Hormone_recep)
PF13416
(SBP_bac_8) 		5 LEU A 194
LEU A 197
ILE A 163
GLU A 155
LEU A 153
 None
 1.14A 1wopA-4logA:
undetectable		 1wopA-4logA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 271
LEU A 269
ILE A 295
GLU A 283
LEU A 287
 None
 1.13A 1wopA-4mn8A:
undetectable		 1wopA-4mn8A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 271
LEU A 269
ILE A 295
GLU A 283
LEU A 287
 None
 1.20A 1wopA-4mnaA:
undetectable		 1wopA-4mnaA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfn TAU-TUBULIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 225
LEU A 229
ILE A 138
GLU A 294
LEU A 132
 None
 1.21A 1wopA-4nfnA:
2.2		 1wopA-4nfnA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o2x MALTOSE-BINDING
PERIPLASMIC PROTEIN,
ATP-DEPENDENT CLP
PROTEASE ADAPTOR
PROTEIN CLPS
CONTAINING PROTEIN
CHIMERIC CONSTRUCT

(Escherichia
coli;
Plasmodium
falciparum) 		PF02617
(ClpS)
PF13416
(SBP_bac_8) 		5 LEU A 193
LEU A 196
ILE A 162
GLU A 154
LEU A 152
 None
 1.18A 1wopA-4o2xA:
undetectable		 1wopA-4o2xA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozq CHIMERA OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND KINESIN FAMILY
MEMBER 14 PROTEIN

(Escherichia
coli;
Mus musculus) 		PF00225
(Kinesin)
PF13416
(SBP_bac_8) 		5 LEU A-178
LEU A-175
ILE A-209
GLU A-217
LEU A-219
 None
 0.99A 1wopA-4ozqA:
undetectable		 1wopA-4ozqA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj1 60 KDA HEAT SHOCK
PROTEIN,
MITOCHONDRIAL

(Homo sapiens) 		PF00118
(Cpn60_TCP1) 		5 LEU A 187
LEU A 380
ILE A 161
GLU A 409
LEU A 401
 None
 1.25A 1wopA-4pj1A:
undetectable		 1wopA-4pj1A:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfh GLUCOSE-6-PHOSPHATE
ISOMERASE

(Trypanosoma
cruzi) 		PF00342
(PGI) 		5 GLU A 123
LEU A 120
ILE A  66
GLU A  62
LEU A  60
 None
 1.25A 1wopA-4qfhA:
undetectable		 1wopA-4qfhA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0y MALTOSE-BINDING
PERIPLASMIC PROTEIN,
DISKS
LARGE-ASSOCIATED
PROTEIN 1

(Escherichia
coli;
Rattus
norvegicus) 		PF03359
(GKAP)
PF13416
(SBP_bac_8) 		5 LEU A 192
LEU A 195
ILE A 161
GLU A 153
LEU A 151
 None
 1.09A 1wopA-4r0yA:
undetectable		 1wopA-4r0yA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rwf MALTOSE TRANSPORTER
SUBUNIT, RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 2,
CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
FUSION PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF02793
(HRM)
PF04901
(RAMP)
PF13416
(SBP_bac_8) 		5 LEU A 194
LEU A 197
ILE A 163
GLU A 155
LEU A 153
 None
None
None
MAL  A2201 (-3.7A)
None
 1.24A 1wopA-4rwfA:
undetectable		 1wopA-4rwfA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tsm MALTOSE-BINDING
PROTEIN, PILIN
CHIMERA

(Escherichia
coli;
Clostridioides
difficile) 		PF13416
(SBP_bac_8) 		5 LEU A 192
LEU A 195
ILE A 161
GLU A 153
LEU A 151
 None
None
None
MTT  A1209 (-3.2A)
None
 1.23A 1wopA-4tsmA:
undetectable		 1wopA-4tsmA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uvj COHESIN SUBUNIT SCC3

(Saccharomyces
cerevisiae) 		no annotation 5 LEU A 816
LEU A 813
ILE A 774
GLU A 787
LEU A 781
 None
 1.16A 1wopA-4uvjA:
undetectable		 1wopA-4uvjA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wvi MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SIGNAL
PEPTIDASE IB

(Escherichia
coli;
Staphylococcus
aureus) 		PF00717
(Peptidase_S24)
PF13416
(SBP_bac_8) 		5 LEU A 198
LEU A 201
ILE A 167
GLU A 159
LEU A 157
 None
None
None
MAL  A 601 (-3.6A)
None
 1.20A 1wopA-4wviA:
undetectable		 1wopA-4wviA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wyi MONOGALACTOSYLDIACYL
GLYCEROL SYNTHASE 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF04101
(Glyco_tran_28_C)
PF06925
(MGDG_synth) 		5 LEU A 373
LEU A 369
ILE A 406
ILE A 414
LEU A 352
 None
 1.15A 1wopA-4wyiA:
undetectable		 1wopA-4wyiA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmv AMINOPEPTIDASE N

(Escherichia
coli) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		5 LEU A 851
LEU A 848
ILE A 827
ILE A 632
LEU A 833
 None
 1.20A 1wopA-4xmvA:
undetectable		 1wopA-4xmvA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z61 PHYTOSULFOKINE
RECEPTOR 1

(Daucus carota) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 LEU A 181
LEU A 177
ILE A 184
GLU A 166
LEU A 189
 None
 1.20A 1wopA-4z61A:
undetectable		 1wopA-4z61A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7e LMO1422 PROTEIN

(Listeria
monocytogenes) 		PF04069
(OpuAC) 		5 LEU A 263
GLU A 458
LEU A 459
ILE A 236
LEU A 453
 None
 1.06A 1wopA-4z7eA:
undetectable		 1wopA-4z7eA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7e LMO1422 PROTEIN

(Listeria
monocytogenes) 		PF04069
(OpuAC) 		5 LEU A 263
GLU A 458
LEU A 459
ILE A 236
MET A 448
 None
 1.23A 1wopA-4z7eA:
undetectable		 1wopA-4z7eA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5g FORMATE--TETRAHYDROF
OLATE LIGASE

(Tepidanaerobacter
acetatoxydans) 		PF01268
(FTHFS) 		5 GLU A 388
LEU A 391
GLU A 423
ILE A 419
LEU A 407
 None
 1.18A 1wopA-5a5gA:
undetectable		 1wopA-5a5gA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN

(Escherichia
coli;
Pyrococcus
furiosus) 		PF13416
(SBP_bac_8) 		5 LEU A 192
LEU A 195
ILE A 161
GLU A 153
LEU A 151
 None
None
None
MAL  A 901 (-3.7A)
None
 1.16A 1wopA-5azaA:
undetectable		 1wopA-5azaA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9u GLYCOSYLTRANSFERASE-
STABILIZING PROTEIN
GTF2

(Streptococcus
gordonii) 		no annotation 5 LEU B 355
LEU B 378
ILE B 353
GLU B 410
LEU B 408
 None
 1.20A 1wopA-5e9uB:
undetectable		 1wopA-5e9uB:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ehk LANTIBIOTIC
DEHYDRATASE

(Microbispora
corallina) 		PF04738
(Lant_dehydr_N)
PF14028
(Lant_dehydr_C) 		5 LEU A 737
GLU A 753
LEU A 749
ILE A 135
LEU A 128
 None
 1.13A 1wopA-5ehkA:
1.3		 1wopA-5ehkA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ex6 CYTOCHROME P450

(Streptomyces
toyocaensis) 		no annotation 5 LEU C 355
LEU C 352
ILE C 119
GLU C 201
LEU C 155
 None
HEM  C 502 ( 4.9A)
None
None
None
 1.02A 1wopA-5ex6C:
undetectable		 1wopA-5ex6C:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gxv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PIGG

(Escherichia
coli;
Serratia) 		PF13416
(SBP_bac_8) 		5 LEU A 194
LEU A 197
ILE A 163
GLU A 155
LEU A 153
 None
 1.20A 1wopA-5gxvA:
0.0		 1wopA-5gxvA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzg F-BOX/LRR-REPEAT
MAX2 HOMOLOG

(Oryza sativa) 		no annotation 5 LEU B 384
LEU B 359
ILE B 403
GLU B 347
LEU B 349
 None
 1.02A 1wopA-5hzgB:
undetectable		 1wopA-5hzgB:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzl LMO2445 PROTEIN

(Listeria
monocytogenes) 		no annotation 5 LEU B  64
LEU B  69
ILE B  29
GLU B 104
ILE B  81
 None
 1.21A 1wopA-5hzlB:
2.6		 1wopA-5hzlB:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iic MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR

(Escherichia
coli;
Haliotis
rufescens) 		PF11386
(VERL)
PF13416
(SBP_bac_8) 		5 LEU A4161
LEU A4164
ILE A4130
GLU A4122
LEU A4120
 None
None
None
MAL  A4501 (-3.8A)
None
 1.21A 1wopA-5iicA:
undetectable		 1wopA-5iicA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5imk V-SET AND
IMMUNOGLOBULIN
DOMAIN-CONTAINING
PROTEIN 4

(Homo sapiens) 		PF07686
(V-set) 		5 LEU A  67
LEU A  81
ILE A  48
GLU A   8
LEU A 114
 None
 1.23A 1wopA-5imkA:
undetectable		 1wopA-5imkA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jk0 TYROSINE RECOMBINASE
XERH

(Helicobacter
pylori) 		PF00589
(Phage_integrase) 		5 LEU A 301
GLU A 179
LEU A 175
ILE A 296
MET A 310
 None
 1.23A 1wopA-5jk0A:
undetectable		 1wopA-5jk0A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jqe SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,CASPASE-8
CHIMERA

(Escherichia
coli) 		PF01335
(DED)
PF13416
(SBP_bac_8) 		5 LEU A 204
LEU A 207
ILE A 173
GLU A 165
LEU A 163
 None
 1.13A 1wopA-5jqeA:
undetectable		 1wopA-5jqeA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k94 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PROTEIN
TRANSLOCASE SUBUNIT
SECA,MALTOSE-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli) 		PF01043
(SecA_PP_bind)
PF01547
(SBP_bac_1)
PF13416
(SBP_bac_8) 		5 LEU A1192
LEU A1195
ILE A 161
GLU A 153
LEU A 151
 None
None
None
B3P  A1401 (-4.0A)
None
 1.15A 1wopA-5k94A:
undetectable		 1wopA-5k94A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5llq METHYLATED-DNA--PROT
EIN-CYSTEINE
METHYLTRANSFERASE

(Sulfolobus
solfataricus) 		PF01035
(DNA_binding_1) 		5 LEU A 142
GLU A 145
LEU A 141
ILE A  64
LEU A 115
 None
 1.18A 1wopA-5llqA:
undetectable		 1wopA-5llqA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lm7 TRANSCRIPTION
TERMINATION/ANTITERM
INATION PROTEIN NUSA

(Escherichia
coli) 		PF00575
(S1)
PF08529
(NusA_N)
PF13184
(KH_5) 		5 LEU A 205
GLU A 269
LEU A 266
GLU A 165
LEU A 168
 None
 1.19A 1wopA-5lm7A:
undetectable		 1wopA-5lm7A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mc9 LAMININ SUBUNIT
ALPHA-1
LAMININ SUBUNIT
BETA-1

(Mus musculus;
Mus musculus) 		PF00054
(Laminin_G_1)
PF06009
(Laminin_II)
no annotation 		5 LEU B1764
GLU B1760
LEU B1761
ILE A2110
LEU A2103
 None
 1.17A 1wopA-5mc9B:
undetectable		 1wopA-5mc9B:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 5 LEU A 886
LEU A 801
ILE A 881
ILE A 871
LEU A 877
 None
 1.21A 1wopA-5mwpA:
undetectable		 1wopA-5mwpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ttd MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PILIN
ISOPEPTIDE LINKAGE
DOMAIN PROTEIN

(Escherichia
coli;
Streptococcus
pyogenes) 		PF12892
(FctA)
PF13416
(SBP_bac_8) 		5 LEU A 198
LEU A 201
ILE A 167
GLU A 159
LEU A 157
 None
None
None
MLR  A 501 (-2.8A)
None
 1.21A 1wopA-5ttdA:
undetectable		 1wopA-5ttdA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vaw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TYPE IV
PILIN PILA

(Acinetobacter
baumannii;
Escherichia
coli) 		no annotation 5 LEU A 192
LEU A 195
ILE A 161
GLU A 153
LEU A 151
 None
 1.22A 1wopA-5vawA:
0.0		 1wopA-5vawA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wfc HISTONE-LYSINE-N-MET
HYLTRANSFERASE EZH2,
POLYCOMB PROTEIN
SUZ12 CHIMERA

(Chaetomium
thermophilum) 		no annotation 5 LEU B 388
LEU B 385
ILE B 390
GLU B 407
LEU B 398
 None
 1.19A 1wopA-5wfcB:
undetectable		 1wopA-5wfcB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wtk CRISPR-ASSOCIATED
ENDORIBONUCLEASE
C2C2

(Leptotrichia
shahii) 		no annotation 5 LEU A1174
GLU A1178
ILE A1079
ILE A1382
LEU A1378
 None
 1.07A 1wopA-5wtkA:
undetectable		 1wopA-5wtkA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wvm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TWO-COMPONEN
T SYSTEM SENSOR
KINASE

(Escherichia
coli;
Serratia
marcescens) 		no annotation 5 LEU A 194
LEU A 197
ILE A 163
GLU A 155
LEU A 153
 None
 1.23A 1wopA-5wvmA:
undetectable		 1wopA-5wvmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvs VP2

(Aquareovirus C) 		no annotation 5 LEU 21066
LEU 21263
ILE 21204
LEU 21233
MET 21229
 None
 1.23A 1wopA-5zvs2:
undetectable		 1wopA-5zvs2:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ch0 -

(-) 		no annotation 5 LEU C  63
LEU C  54
ILE C 111
GLU C 102
LEU C 104
 None
 1.02A 1wopA-6ch0C:
undetectable		 1wopA-6ch0C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cu5 PROTEIN ARGININE
N-METHYLTRANSFERASE

(Naegleria
fowleri) 		no annotation 5 LEU A 223
LEU A 127
ILE A 226
GLU A 260
MET A 156
 None
 1.24A 1wopA-6cu5A:
undetectable		 1wopA-6cu5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ejf -

(-) 		no annotation 5 LEU J 183
LEU J 201
ILE J 178
GLU J 217
LEU J 215
 None
 1.09A 1wopA-6ejfJ:
undetectable		 1wopA-6ejfJ:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ero DIMETHYLADENOSINE
TRANSFERASE 2,
MITOCHONDRIAL,DIMETH
YLADENOSINE
TRANSFERASE 2,
MITOCHONDRIAL

(Homo sapiens) 		no annotation 5 LEU A 268
LEU A 290
ILE A 267
GLU A 308
LEU A 240
 None
 1.14A 1wopA-6eroA:
undetectable		 1wopA-6eroA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gl3 -

(-) 		no annotation 5 LEU A 785
LEU A 737
GLU A 752
ILE A 769
LEU A 666
 None
 1.25A 1wopA-6gl3A:
undetectable		 1wopA-6gl3A:
undetectable