SIMILAR PATTERNS OF AMINO ACIDS FOR 1WOP_A_FFOA2887_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1d7w | MYELOPEROXIDASE (Homo sapiens) |
PF03098(An_peroxidase) | 3 | ASP C 142GLU C 408ARG C 403 | None | 0.85A | 1wopA-1d7wC:0.0 | 1wopA-1d7wC:22.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dms | DMSO REDUCTASE (Rhodobactercapsulatus) |
PF00384(Molybdopterin)PF01568(Molydop_binding) | 3 | ASP A 629GLU A 760ARG A 693 | None | 0.88A | 1wopA-1dmsA:0.0 | 1wopA-1dmsA:18.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ef7 | CATHEPSIN X (Homo sapiens) |
PF00112(Peptidase_C1) | 3 | ASP A 191GLU A 208ARG A 160 | None | 0.79A | 1wopA-1ef7A:0.0 | 1wopA-1ef7A:19.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n71 | AAC(6')-II (Enterococcusfaecium) |
PF00583(Acetyltransf_1) | 3 | ASP A 54GLU A 79ARG A 90 | None | 0.88A | 1wopA-1n71A:0.0 | 1wopA-1n71A:18.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tz7 | 4-ALPHA-GLUCANOTRANSFERASE (Aquifexaeolicus) |
PF02446(Glyco_hydro_77) | 3 | ASP A 242GLU A 333ARG A 343 | None | 0.74A | 1wopA-1tz7A:undetectable | 1wopA-1tz7A:23.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uxi | MALATE DEHYDROGENASE (Chloroflexusaurantiacus) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 3 | ASP A 90GLU A 178ARG A 151 | NoneNoneFUM A1311 (-2.8A) | 0.68A | 1wopA-1uxiA:0.0 | 1wopA-1uxiA:23.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uz8 | IGG FAB (IGG3,KAPPA) HEAVY CHAIN291-2G3-A (Mus musculus) |
PF07654(C1-set)PF07686(V-set) | 3 | ASP B 101GLU B 6ARG B 71 | None | 0.86A | 1wopA-1uz8B:0.6 | 1wopA-1uz8B:21.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w45 | ANNEXIN A8 (Homo sapiens) |
PF00191(Annexin) | 3 | ASP A 287GLU A 98ARG A 56 | None | 0.85A | 1wopA-1w45A:0.0 | 1wopA-1w45A:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wa5 | IMPORTIN ALPHASUBUNITIMPORTIN ALPHARE-EXPORTER (Saccharomycescerevisiae;Saccharomycescerevisiae) |
PF00514(Arm)PF01749(IBB)PF16186(Arm_3)PF03378(CAS_CSE1)PF03810(IBN_N)PF08506(Cse1) | 3 | ASP B 49GLU C 226ARG C 159 | None | 0.59A | 1wopA-1wa5B:0.0 | 1wopA-1wa5B:20.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1wop | AMINOMETHYLTRANSFERASE (Thermotogamaritima) |
PF01571(GCV_T)PF08669(GCV_T_C) | 3 | ASP A 96GLU A 195ARG A 362 | FFO A2887 (-3.1A)FFO A2887 (-2.8A)FFO A2887 (-3.4A) | 0.00A | 1wopA-1wopA:65.4 | 1wopA-1wopA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a5l | TRP REPRESSORBINDING PROTEIN WRBA (Pseudomonasaeruginosa) |
PF03358(FMN_red) | 3 | ASP A 169GLU A 178ARG A 22 | None | 0.86A | 1wopA-2a5lA:undetectable | 1wopA-2a5lA:20.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ako | GLUTAMATE 5-KINASE (Campylobacterjejuni) |
PF00696(AA_kinase) | 3 | ASP A 242GLU A 251ARG A 180 | None | 0.61A | 1wopA-2akoA:undetectable | 1wopA-2akoA:23.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bqx | INORGANICPYROPHOSPHATASE (Helicobacterpylori) |
PF00719(Pyrophosphatase) | 3 | ASP A 64GLU A 20ARG A 42 | None | 0.75A | 1wopA-2bqxA:undetectable | 1wopA-2bqxA:20.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2br4 | CEPHALOSPORINHYDROXYLASE CMCI (Streptomycesclavuligerus) |
PF04989(CmcI) | 3 | ASP A 187GLU A 87ARG A 121 | MG A 300 (-3.3A)SAM A 301 (-3.0A)SAM A 301 (-3.1A) | 0.88A | 1wopA-2br4A:undetectable | 1wopA-2br4A:19.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g9d | SUCCINYLGLUTAMATEDESUCCINYLASE (Vibrio cholerae) |
PF04952(AstE_AspA) | 3 | ASP A 274GLU A 291ARG A 264 | None | 0.87A | 1wopA-2g9dA:undetectable | 1wopA-2g9dA:21.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gzh | RAS-RELATED PROTEINRAB-11ARAB11-FIP2 LONGISOFORM (Homo sapiens;Homo sapiens) |
PF00071(Ras)PF09457(RBD-FIP) | 3 | ASP B 482GLU A 108ARG A 82 | None MG A 951 (-4.5A)None | 0.89A | 1wopA-2gzhB:undetectable | 1wopA-2gzhB:17.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i32 | ANTI-SILENCINGFACTOR 1 PARALOG AHISTONE REGULATORYHOMOLOG A (Homo sapiens;Homo sapiens) |
PF04729(ASF1_hist_chap)PF09453(HIRA_B) | 3 | ASP A 77GLU E 451ARG E 458 | None | 0.83A | 1wopA-2i32A:undetectable | 1wopA-2i32A:19.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iuk | SEED LIPOXYGENASE (Glycine max) |
PF00305(Lipoxygenase)PF01477(PLAT) | 3 | ASP A 276GLU A 794ARG A 265 | None | 0.76A | 1wopA-2iukA:1.6 | 1wopA-2iukA:19.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2kua | BCL-2-LIKE PROTEIN10 (Mus musculus) |
PF00452(Bcl-2) | 3 | ASP A 3GLU A 10ARG A 142 | None | 0.85A | 1wopA-2kuaA:undetectable | 1wopA-2kuaA:17.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o3b | NUCLEASESUGAR-NON-SPECIFICNUCLEASE INHIBITOR (Nostoc sp. PCC7120;Nostoc sp. PCC7120) |
PF01223(Endonuclease_NS)PF07924(NuiA) | 3 | ASP A 130GLU B 24ARG A 98 | None MG A 303 ( 4.0A)None | 0.78A | 1wopA-2o3bA:undetectable | 1wopA-2o3bA:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pjr | PROTEIN (HELICASEPCRA)PROTEIN (HELICASEPCRA) (Geobacillusstearothermophilus;Geobacillusstearothermophilus) |
PF00580(UvrD-helicase)PF13361(UvrD_C)PF13361(UvrD_C) | 3 | ASP B 594GLU B 640ARG A 359 | None | 0.73A | 1wopA-2pjrB:undetectable | 1wopA-2pjrB:13.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rb7 | PEPTIDASE,M20/M25/M40 FAMILY (Desulfovibrioalaskensis) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 3 | ASP A 100GLU A 173ARG A 277 | None | 0.75A | 1wopA-2rb7A:undetectable | 1wopA-2rb7A:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vro | ALDEHYDEDEHYDROGENASE (Paraburkholderiaxenovorans) |
PF00171(Aldedh) | 3 | ASP A 101GLU A 257ARG A 300 | None | 0.82A | 1wopA-2vroA:undetectable | 1wopA-2vroA:23.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y9y | IMITATION SWITCHPROTEIN 1(DEL_ATPASE)ISWI ONE COMPLEXPROTEIN 3 (Saccharomycescerevisiae;Saccharomycescerevisiae) |
PF09110(HAND)PF09111(SLIDE)PF15612(WHIM1) | 3 | ASP B 548GLU A 995ARG A1035 | None | 0.72A | 1wopA-2y9yB:undetectable | 1wopA-2y9yB:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aqc | COMPONENT B OFHEXAPRENYLDIPHOSPHATE SYNTHASE (Micrococcusluteus) |
PF00348(polyprenyl_synt) | 3 | ASP B 212GLU B 146ARG B 48 | None2DE B 329 (-3.9A)None | 0.77A | 1wopA-3aqcB:undetectable | 1wopA-3aqcB:23.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d0q | PROTEIN CALG3 (Micromonosporaechinospora) |
PF06722(DUF1205) | 3 | ASP A 81GLU A 183ARG A 320 | None | 0.78A | 1wopA-3d0qA:undetectable | 1wopA-3d0qA:22.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d6n | ASPARTATECARBAMOYLTRANSFERASE (Aquifexaeolicus) |
PF00185(OTCace)PF02729(OTCace_N) | 3 | ASP B 258GLU B 217ARG B 97 | NoneNoneFLC B 292 (-2.8A) | 0.87A | 1wopA-3d6nB:undetectable | 1wopA-3d6nB:23.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e0s | UNCHARACTERIZEDPROTEIN (Chlorobaculumtepidum) |
PF05235(CHAD) | 3 | ASP A 254GLU A 422ARG A 411 | None | 0.88A | 1wopA-3e0sA:undetectable | 1wopA-3e0sA:23.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e4p | C4-DICARBOXYLATETRANSPORT SENSORPROTEIN DCTB (Sinorhizobiummeliloti) |
no annotation | 3 | ASP A 206GLU A 119ARG A 175 | None | 0.72A | 1wopA-3e4pA:undetectable | 1wopA-3e4pA:23.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ecn | HIGH AFFINITYCAMP-SPECIFIC ANDIBMX-INSENSITIVE3',5'-CYCLICPHOSPHODIESTERASE 8A (Homo sapiens) |
PF00233(PDEase_I) | 3 | ASP A 801GLU A 575ARG A 524 | None | 0.66A | 1wopA-3ecnA:undetectable | 1wopA-3ecnA:22.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eiz | INORGANICPYROPHOSPHATASE (Burkholderiapseudomallei) |
PF00719(Pyrophosphatase) | 3 | ASP A 66GLU A 21ARG A 44 | None | 0.76A | 1wopA-3eizA:undetectable | 1wopA-3eizA:18.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3emj | INORGANICPYROPHOSPHATASE (Rickettsiaprowazekii) |
PF00719(Pyrophosphatase) | 3 | ASP A 65GLU A 20ARG A 43 | None | 0.84A | 1wopA-3emjA:undetectable | 1wopA-3emjA:17.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fzu | IMMUNOGLOBULIN IGG1FAB, HEAVY CHAIN (Homo sapiens) |
no annotation | 3 | ASP H 106GLU H 6ARG H 74 | None | 0.88A | 1wopA-3fzuH:1.6 | 1wopA-3fzuH:21.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3glg | DNA POLYMERASE IIISUBUNIT DELTA (Escherichiacoli) |
PF06144(DNA_pol3_delta)PF14840(DNA_pol3_delt_C) | 3 | ASP A 27GLU A 239ARG A 228 | None | 0.86A | 1wopA-3glgA:undetectable | 1wopA-3glgA:21.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h86 | ADENYLATE KINASE (Methanococcusmaripaludis) |
no annotation | 3 | ASP B 181GLU B 29ARG B 192 | None | 0.82A | 1wopA-3h86B:undetectable | 1wopA-3h86B:20.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3luf | TWO-COMPONENT SYSTEMRESPONSEREGULATOR/GGDEFDOMAIN PROTEIN (Aeromonassalmonicida) |
PF00072(Response_reg) | 3 | ASP A 10GLU A 63ARG A 71 | MG A 301 (-2.6A)NoneNone | 0.70A | 1wopA-3lufA:undetectable | 1wopA-3lufA:22.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o5a | PERIPLASMIC NITRATEREDUCTASE (Cupriavidusnecator) |
PF00384(Molybdopterin)PF01568(Molydop_binding)PF04879(Molybdop_Fe4S4) | 3 | ASP A 617GLU A 415ARG A 400 | NoneNoneFMT A 803 (-4.0A) | 0.88A | 1wopA-3o5aA:undetectable | 1wopA-3o5aA:18.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o98 | BIFUNCTIONALGLUTATHIONYLSPERMIDINESYNTHETASE/AMIDASE (Escherichiacoli) |
PF03738(GSP_synth)PF05257(CHAP) | 3 | ASP A 334GLU A 392ARG A 598 | None | 0.78A | 1wopA-3o98A:undetectable | 1wopA-3o98A:20.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pko | GERANYLGERANYLPYROPHOSPHATESYNTHASE (Lactobacillusbrevis) |
PF00348(polyprenyl_synt) | 3 | ASP A 216GLU A 150ARG A 50 | NoneNoneCIT A 326 (-2.6A) | 0.84A | 1wopA-3pkoA:undetectable | 1wopA-3pkoA:23.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pvj | ALPHA-KETOGLUTARATE-DEPENDENT TAURINEDIOXYGENASE (Pseudomonasputida) |
PF02668(TauD) | 3 | ASP A 64GLU A 34ARG A 188 | None | 0.67A | 1wopA-3pvjA:undetectable | 1wopA-3pvjA:23.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qc1 | IMMUNOGLOBULIN-BINDING PROTEIN 1 (Mus musculus) |
PF04177(TAP42) | 3 | ASP A 26GLU A 181ARG A 200 | None | 0.83A | 1wopA-3qc1A:undetectable | 1wopA-3qc1A:21.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3swx | PROBABLE ENOYL-COAHYDRATASE/ISOMERASE (Mycobacteroidesabscessus) |
PF00378(ECH_1) | 3 | ASP A 93GLU A 115ARG A 152 | None | 0.85A | 1wopA-3swxA:undetectable | 1wopA-3swxA:21.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sxf | CALMODULIN-DOMAINPROTEIN KINASE 1 (Toxoplasmagondii) |
PF00069(Pkinase)PF13499(EF-hand_7) | 3 | ASP A 107GLU A 183ARG A 156 | None | 0.88A | 1wopA-3sxfA:undetectable | 1wopA-3sxfA:22.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vc1 | GERANYL DIPHOSPHATE2-C-METHYLTRANSFERASE (Streptomycescoelicolor) |
PF08241(Methyltransf_11) | 3 | ASP A 42GLU A 142ARG A 117 | None | 0.88A | 1wopA-3vc1A:undetectable | 1wopA-3vc1A:20.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w9v | PHOSPHATE-BINDINGPROTEIN (unidentifiedprokaryoticorganism) |
PF12849(PBP_like_2) | 3 | ASP A 224GLU A 243ARG A 131 | None | 0.86A | 1wopA-3w9vA:undetectable | 1wopA-3w9vA:20.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b0t | PUP--PROTEIN LIGASE (Corynebacteriumglutamicum) |
PF03136(Pup_ligase) | 3 | ASP A 208GLU A 70ARG A 422 | ADP A1478 (-4.4A) MG A1479 ( 4.0A)None | 0.74A | 1wopA-4b0tA:undetectable | 1wopA-4b0tA:22.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c3o | HYDROGENASE-1 LARGESUBUNIT (Salmonellaenterica) |
PF00374(NiFeSe_Hases) | 3 | ASP A 118GLU A 73ARG A 89 | None | 0.73A | 1wopA-4c3oA:undetectable | 1wopA-4c3oA:21.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cit | VANADIUM-DEPENDENTHALOPEROXIDASE (Zobelliagalactanivorans) |
PF01569(PAP2) | 3 | ASP A 153GLU A 119ARG A 56 | None | 0.80A | 1wopA-4citA:undetectable | 1wopA-4citA:21.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4esw | PYRIMIDINEBIOSYNTHESIS ENZYMETHI13 (Candidaalbicans) |
PF09084(NMT1) | 3 | ASP A 312GLU A 86ARG A 277 | None | 0.76A | 1wopA-4eswA:undetectable | 1wopA-4eswA:25.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fgo | PERIPLASMIC PROTEIN (Legionellapneumophila) |
PF06035(Peptidase_C93) | 3 | ASP A 136GLU A 128ARG A 78 | CA A 301 (-2.6A)NoneNone | 0.83A | 1wopA-4fgoA:undetectable | 1wopA-4fgoA:21.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gp1 | POLYPRENYLSYNTHETASE (Pyrobaculumcalidifontis) |
PF00348(polyprenyl_synt) | 3 | ASP A 226GLU A 148ARG A 49 | NoneNoneDMA A 402 (-3.1A) | 0.83A | 1wopA-4gp1A:undetectable | 1wopA-4gp1A:24.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h0f | LAMININ-BINDINGSURFACE PROTEIN (Streptococcusagalactiae) |
PF01297(ZnuA) | 3 | ASP A 140GLU A 153ARG A 96 | None | 0.84A | 1wopA-4h0fA:undetectable | 1wopA-4h0fA:23.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h3v | OXIDOREDUCTASEDOMAIN PROTEIN (Kribbellaflavida) |
PF01408(GFO_IDH_MocA)PF02894(GFO_IDH_MocA_C) | 3 | ASP A 182GLU A 374ARG A 266 | None | 0.65A | 1wopA-4h3vA:undetectable | 1wopA-4h3vA:20.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ikb | SORTING NEXIN-11 (Homo sapiens) |
PF00787(PX) | 3 | ASP B 93GLU B 29ARG B 57 | None | 0.87A | 1wopA-4ikbB:undetectable | 1wopA-4ikbB:19.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j8f | HEAT SHOCK 70 KDAPROTEIN 1A/1B,HSC70-INTERACTINGPROTEIN (Homo sapiens;Rattusnorvegicus) |
PF00012(HSP70) | 3 | ASP A 32GLU A 48ARG A 479 | None | 0.72A | 1wopA-4j8fA:undetectable | 1wopA-4j8fA:20.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jcs | ENOYL-COAHYDRATASE/ISOMERASE (Cupriavidusmetallidurans) |
PF00378(ECH_1) | 3 | ASP A 169GLU A 160ARG A 136 | None | 0.82A | 1wopA-4jcsA:undetectable | 1wopA-4jcsA:24.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jhj | MIF4GDOMAIN-CONTAININGPROTEIN B (Danio rerio) |
PF02854(MIF4G) | 3 | ASP A 160GLU A 197ARG A 178 | None | 0.81A | 1wopA-4jhjA:undetectable | 1wopA-4jhjA:22.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mt1 | DRUG EFFLUX PROTEIN (Neisseriagonorrhoeae) |
PF00873(ACR_tran) | 3 | ASP A 406GLU A 955ARG A 416 | None | 0.71A | 1wopA-4mt1A:3.5 | 1wopA-4mt1A:16.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o27 | CALCIUM-BINDINGPROTEIN 39SERINE/THREONINE-PROTEIN KINASE 24 (Homo sapiens;Homo sapiens) |
PF08569(Mo25)PF00069(Pkinase) | 3 | ASP B 66GLU A 235ARG A 313 | None | 0.74A | 1wopA-4o27B:undetectable | 1wopA-4o27B:22.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o9x | TCDB2, TCCC3 (Photorhabdusluminescens) |
PF03534(SpvB)PF12255(TcdB_toxin_midC)PF12256(TcdB_toxin_midN) | 3 | ASP A 999GLU A1502ARG A1545 | None | 0.78A | 1wopA-4o9xA:undetectable | 1wopA-4o9xA:9.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p7h | MYOSIN-7,GREENFLUORESCENT PROTEIN (Aequoreavictoria;Homo sapiens) |
PF00063(Myosin_head)PF01353(GFP)PF02736(Myosin_N) | 3 | ASP A 469GLU A 677ARG A 243 | None | 0.88A | 1wopA-4p7hA:undetectable | 1wopA-4p7hA:17.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4po0 | SERUM ALBUMIN (Oryctolaguscuniculus) |
PF00273(Serum_albumin) | 3 | ASP A 563GLU A 571ARG A 521 | None | 0.71A | 1wopA-4po0A:undetectable | 1wopA-4po0A:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pu6 | L-ASPARAGINASE ALPHASUBUNIT (Phaseolusvulgaris) |
PF01112(Asparaginase_2) | 3 | ASP A 146GLU A 21ARG A 32 | None | 0.85A | 1wopA-4pu6A:undetectable | 1wopA-4pu6A:22.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q1l | SNAKE VENOMMETALLOPROTEINASELEUCUROLYSIN-A (Bothropsleucurus) |
PF01421(Reprolysin) | 3 | ASP A 153GLU A 143ARG A 135 | None ZN A 302 ( 4.7A)None | 0.86A | 1wopA-4q1lA:undetectable | 1wopA-4q1lA:20.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q66 | PROTEIN BCH1 (Saccharomycescerevisiae) |
no annotation | 3 | ASP K 256GLU K 383ARG K 308 | None | 0.88A | 1wopA-4q66K:undetectable | 1wopA-4q66K:19.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qg5 | PUTATIVEPHOSPHOGLUCOMUTASE (Leishmaniamajor) |
PF00408(PGM_PMM_IV)PF02878(PGM_PMM_I)PF02879(PGM_PMM_II)PF02880(PGM_PMM_III) | 3 | ASP A 260GLU A 458ARG A 523 | None | 0.81A | 1wopA-4qg5A:0.7 | 1wopA-4qg5A:21.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r7b | CHOLINE KINASE (Streptococcuspneumoniae) |
PF01633(Choline_kinase) | 3 | ASP A 98GLU A 220ARG A 275 | None | 0.78A | 1wopA-4r7bA:undetectable | 1wopA-4r7bA:22.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ras | OXIDOREDUCTASE,NAD-BINDING/IRON-SULFUR CLUSTER-BINDINGPROTEIN (Nitratireductorpacificus) |
PF12838(Fer4_7)PF13486(Dehalogenase) | 3 | ASP A 505GLU A 539ARG A 278 | None | 0.76A | 1wopA-4rasA:undetectable | 1wopA-4rasA:20.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rwf | MALTOSE TRANSPORTERSUBUNIT, RECEPTORACTIVITY-MODIFYINGPROTEIN 2,CALCITONINGENE-RELATED PEPTIDETYPE 1 RECEPTORFUSION PROTEIN (Escherichiacoli;Homo sapiens) |
PF02793(HRM)PF04901(RAMP)PF13416(SBP_bac_8) | 3 | ASP A2090GLU A2047ARG A1097 | NoneEDO A2205 ( 3.2A)None | 0.79A | 1wopA-4rwfA:undetectable | 1wopA-4rwfA:20.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rzm | EPOXIDE HYDROLASELASB (Streptomyceslasaliensis) |
PF12680(SnoaL_2) | 3 | ASP A 207GLU A 116ARG A 54 | None | 0.86A | 1wopA-4rzmA:undetectable | 1wopA-4rzmA:22.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tmk | PROTEIN (THYMIDYLATEKINASE) (Escherichiacoli) |
PF02223(Thymidylate_kin) | 3 | ASP A 56GLU A 12ARG A 113 | NoneT5A A 214 (-3.7A)None | 0.79A | 1wopA-4tmkA:undetectable | 1wopA-4tmkA:22.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u4p | STRUCTURALMAINTENANCE OFCHROMOSOMES PROTEIN2STRUCTURALMAINTENANCE OFCHROMOSOMES PROTEIN4 (Homo sapiens;Homo sapiens) |
PF06470(SMC_hinge)PF06470(SMC_hinge) | 3 | ASP B 641GLU A 547ARG A 668 | None | 0.81A | 1wopA-4u4pB:undetectable | 1wopA-4u4pB:23.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4upl | SULFATASE FAMILYPROTEIN (Ruegeriapomeroyi) |
PF00884(Sulfatase)PF16347(DUF4976) | 3 | ASP A 146GLU A 203ARG A 158 | None | 0.88A | 1wopA-4uplA:undetectable | 1wopA-4uplA:23.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yyf | BETA-N-ACETYLHEXOSAMINIDASE (Mycolicibacteriumsmegmatis) |
PF00933(Glyco_hydro_3) | 3 | ASP A 236GLU A 128ARG A 146 | None | 0.78A | 1wopA-4yyfA:undetectable | 1wopA-4yyfA:23.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zgv | FERREDOXIN RECEPTOR (Pectobacteriumatrosepticum) |
PF07715(Plug) | 3 | ASP A 198GLU A 444ARG A 544 | None | 0.85A | 1wopA-4zgvA:undetectable | 1wopA-4zgvA:18.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zlr | BRAIN TUMOR PROTEIN (Drosophilamelanogaster) |
PF01436(NHL) | 3 | ASP A 880GLU A 944ARG A 949 | None | 0.64A | 1wopA-4zlrA:undetectable | 1wopA-4zlrA:23.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zxl | O-GLCNACASE NAGJ (Clostridiumperfringens) |
PF02838(Glyco_hydro_20b)PF07555(NAGidase) | 3 | ASP A 474GLU A 528ARG A 495 | CD A 715 (-2.2A)NoneNone | 0.87A | 1wopA-4zxlA:undetectable | 1wopA-4zxlA:22.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a3f | DYNAMIN 3 (Homo sapiens) |
PF00169(PH)PF00350(Dynamin_N)PF01031(Dynamin_M)PF02212(GED) | 3 | ASP A 241GLU A 79ARG A 98 | None | 0.80A | 1wopA-5a3fA:undetectable | 1wopA-5a3fA:19.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b01 | MOEN5 (Streptomycesviridosporus) |
no annotation | 3 | ASP A 71GLU A 195ARG A 129 | None | 0.87A | 1wopA-5b01A:undetectable | 1wopA-5b01A:22.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bq1 | CARBONIC ANHYDRASE (Pseudomonasaeruginosa) |
PF00484(Pro_CA) | 3 | ASP A 186GLU A 149ARG A 105 | None | 0.85A | 1wopA-5bq1A:undetectable | 1wopA-5bq1A:21.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bvi | INTERFERONREGULATORY FACTOR 4 (Mus musculus) |
PF10401(IRF-3) | 3 | ASP A 337GLU A 367ARG A 411 | None | 0.87A | 1wopA-5bviA:undetectable | 1wopA-5bviA:18.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cov | NAEGLERIA GRUBERIRNA LIGASE (Naegleriagruberi) |
PF09414(RNA_ligase) | 3 | ASP A 183GLU A 193ARG A 207 | None | 0.88A | 1wopA-5covA:undetectable | 1wopA-5covA:23.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cuy | ACIDOCALCISOMALPYROPHOSPHATASE (Trypanosomabrucei) |
PF00719(Pyrophosphatase) | 3 | ASP A 291GLU A 229ARG A 259 | MG A 902 (-3.2A)NoneNone | 0.77A | 1wopA-5cuyA:undetectable | 1wopA-5cuyA:22.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cuy | ACIDOCALCISOMALPYROPHOSPHATASE (Trypanosomabrucei) |
PF00719(Pyrophosphatase) | 3 | ASP A 328GLU A 229ARG A 259 | MG A 902 (-4.3A)NoneNone | 0.78A | 1wopA-5cuyA:undetectable | 1wopA-5cuyA:22.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dxw | PD-L1 NANOBODY (Mus musculus) |
PF07686(V-set) | 3 | ASP A 104GLU A 8ARG A 74 | None | 0.63A | 1wopA-5dxwA:undetectable | 1wopA-5dxwA:16.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ed1 | DOUBLE-STRANDEDRNA-SPECIFIC EDITASE1 (Homo sapiens) |
PF02137(A_deamin) | 3 | ASP A 606GLU A 412ARG A 423 | None | 0.60A | 1wopA-5ed1A:undetectable | 1wopA-5ed1A:22.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eeb | ALDEHYDEDEHYDROGENASE (Pyrobaculumferrireducens) |
PF00171(Aldedh) | 3 | ASP A 472GLU A 463ARG A 70 | None | 0.82A | 1wopA-5eebA:undetectable | 1wopA-5eebA:21.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hpk | E3 UBIQUITIN-PROTEINLIGASE NEDD4-LIKE (Homo sapiens) |
PF00632(HECT) | 3 | ASP A 728GLU A 829ARG A 877 | None | 0.81A | 1wopA-5hpkA:undetectable | 1wopA-5hpkA:21.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i1f | UTP--GLUCOSE-1-PHOSPHATEURIDYLYLTRANSFERASE (Burkholderiavietnamiensis) |
PF00483(NTP_transferase) | 3 | ASP A 133GLU A 228ARG A 59 | MG A 303 ( 2.6A) MG A 302 ( 3.9A)None | 0.61A | 1wopA-5i1fA:undetectable | 1wopA-5i1fA:22.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ja9 | NANOBODY 6 (Lama glama) |
PF07686(V-set) | 3 | ASP A 106GLU A 7ARG A 73 | None | 0.82A | 1wopA-5ja9A:1.9 | 1wopA-5ja9A:12.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k1u | NAD(P)H:FLAVINOXIDOREDUCTASE SYE4 (Shewanellaoneidensis) |
PF00724(Oxidored_FMN) | 3 | ASP A 40GLU A 65ARG A 140 | None | 0.88A | 1wopA-5k1uA:undetectable | 1wopA-5k1uA:22.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5odr | HETERODISULFIDEREDUCTASE, SUBUNIT AMETHYL-VIOLOGENREDUCINGHYDROGENASE, SUBUNITG (Methanothermococcusthermolithotrophicus;Methanothermococcusthermolithotrophicus) |
PF07992(Pyr_redox_2)PF13187(Fer4_9)PF01058(Oxidored_q6) | 3 | ASP E 247GLU E 138ARG A 651 | None | 0.86A | 1wopA-5odrE:undetectable | 1wopA-5odrE:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wna | MAB 3D3 FAB HEAVYCHAIN (Homo sapiens) |
no annotation | 3 | ASP H 112GLU H 6ARG H 72 | None | 0.80A | 1wopA-5wnaH:2.0 | 1wopA-5wnaH:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xqo | PCRGLX PROTEIN (Penicilliumchrysogenum) |
no annotation | 3 | ASP A 711GLU A 587ARG A 845 | NoneADA A1004 ( 3.7A)None | 0.81A | 1wopA-5xqoA:undetectable | 1wopA-5xqoA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xsy | SODIUM CHANNELPROTEIN (Electrophoruselectricus) |
PF00520(Ion_trans)PF06512(Na_trans_assoc) | 3 | ASP A 307GLU A 301ARG A 335 | None | 0.54A | 1wopA-5xsyA:undetectable | 1wopA-5xsyA:12.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ya1 | AUTOINDUCER-2 KINASE (Escherichiacoli) |
no annotation | 3 | ASP A 186GLU A 308ARG A 150 | None | 0.81A | 1wopA-5ya1A:undetectable | 1wopA-5ya1A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bxn | DIPHTHAMIDEBIOSYNTHESIS ENZYMEDPH2 (CandidatusMethanoperedensnitroreducens) |
no annotation | 3 | ASP A 263GLU A 29ARG A 293 | None | 0.56A | 1wopA-6bxnA:undetectable | 1wopA-6bxnA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ca6 | PCT64_35S HEAVYCHAIN (Homo sapiens) |
no annotation | 3 | ASP H 101GLU H 6ARG H 71 | None | 0.79A | 1wopA-6ca6H:undetectable | 1wopA-6ca6H:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ehe | OMPT PROTEIN (Vibrio cholerae) |
no annotation | 3 | ASP A 93GLU A 57ARG A 282 | C8E A 407 (-3.8A)NoneACT A 410 ( 4.6A) | 0.88A | 1wopA-6eheA:undetectable | 1wopA-6eheA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ejm | SINGLE CHAIN FVFRAGMENT (Mus musculus) |
no annotation | 3 | ASP H 142GLU H 44ARG H 110 | None | 0.65A | 1wopA-6ejmH:1.7 | 1wopA-6ejmH:undetectable |