SIMILAR PATTERNS OF AMINO ACIDS FOR 1WOP_A_FFOA2887

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1v5v AMINOMETHYLTRANSFERA
SE

(Pyrococcus
horikoshii) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		5 MET A  55
TYR A  87
TYR A 198
ARG A 251
TYR A 260
 None
 0.71A 1wopA-1v5vA:
49.3		 1wopA-1v5vA:
38.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wop AMINOMETHYLTRANSFERA
SE

(Thermotoga
maritima) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		12 MET A  51
TYR A  83
VAL A  98
TYR A 100
VAL A 110
ASN A 112
TYR A 168
TYR A 169
TYR A 188
ARG A 227
TYR A 236
TRP A 256
 FFO  A2887 (-4.6A)
FFO  A2887 (-3.9A)
FFO  A2887 (-4.0A)
None
FFO  A2887 (-4.0A)
FFO  A2887 (-3.3A)
None
FFO  A2887 (-3.6A)
FFO  A2887 (-3.5A)
FFO  A2887 (-3.6A)
FFO  A2887 (-3.9A)
None
 0.00A 1wopA-1wopA:
65.4		 1wopA-1wopA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wsv AMINOMETHYLTRANSFERA
SE

(Homo sapiens) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		6 MET A  56
TYR A 113
VAL A 115
ASN A 117
TYR A 197
ARG A 233
 MET  A  56 (-0.0A)
TYR  A 113 ( 1.3A)
VAL  A 115 (-0.6A)
ASN  A 117 (-0.6A)
TYR  A 197 (-1.3A)
ARG  A 233 (-0.6A)
 1.15A 1wopA-1wsvA:
50.1		 1wopA-1wsvA:
34.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wsv AMINOMETHYLTRANSFERA
SE

(Homo sapiens) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		7 MET A  56
VAL A 115
ASN A 117
TYR A 371
TYR A 197
ARG A 233
TRP A 262
 MET  A  56 (-0.0A)
VAL  A 115 (-0.6A)
ASN  A 117 (-0.6A)
TYR  A 371 (-1.3A)
TYR  A 197 (-1.3A)
ARG  A 233 (-0.6A)
TRP  A 262 ( 0.5A)
 1.09A 1wopA-1wsvA:
50.1		 1wopA-1wsvA:
34.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wsv AMINOMETHYLTRANSFERA
SE

(Homo sapiens) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		5 VAL A 115
TYR A 113
ASN A 117
TYR A 197
ARG A 233
 VAL  A 115 (-0.6A)
TYR  A 113 ( 1.3A)
ASN  A 117 (-0.6A)
TYR  A 197 (-1.3A)
ARG  A 233 (-0.6A)
 1.48A 1wopA-1wsvA:
50.1		 1wopA-1wsvA:
34.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1yx2 AMINOMETHYLTRANSFERA
SE

(Bacillus
subtilis) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		6 MET A  52
TYR A  84
TYR A 101
VAL A 111
ASN A 113
TYR A 189
 None
 0.46A 1wopA-1yx2A:
48.9		 1wopA-1yx2A:
45.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zup HYPOTHETICAL PROTEIN
TM1739

(Thermotoga
maritima) 		PF09376
(NurA) 		5 MET A 203
VAL A 237
VAL A 215
ARG A 247
TYR A 245
 None
 1.41A 1wopA-1zupA:
0.0		 1wopA-1zupA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zpb NITRILE HYDRATASE
SUBUNIT ALPHA
NITRILE HYDRATASE
SUBUNIT BETA

(Rhodococcus
erythropolis;
Rhodococcus
erythropolis) 		PF02979
(NHase_alpha)
PF02211
(NHase_beta) 		5 MET B  62
VAL B  55
VAL B  58
TYR B  73
TRP A 117
 None
 1.21A 1wopA-2zpbB:
undetectable		 1wopA-2zpbB:
20.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3a8k AMINOMETHYLTRANSFERA
SE

(Escherichia
coli) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		8 MET A  51
TYR A  84
TYR A 101
VAL A 111
ASN A 113
TYR A 188
ARG A 223
TRP A 252
 None
 0.50A 1wopA-3a8kA:
47.8		 1wopA-3a8kA:
39.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gir AMINOMETHYLTRANSFERA
SE

(Bartonella
henselae) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		8 MET A  63
TYR A  95
VAL A 122
ASN A 124
TYR A 369
TYR A 194
ARG A 230
TRP A 259
 None
 1.11A 1wopA-3girA:
48.1		 1wopA-3girA:
31.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis) 		PF01266
(DAO)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF16350
(FAO_M) 		5 TYR A 539
ASN A 568
TYR A 631
TYR A 651
TYR A 699
 THG  A2887 (-3.9A)
THG  A2887 ( 4.1A)
None
THG  A2887 (-4.3A)
THG  A2887 (-4.1A)
 0.73A 1wopA-3gsiA:
47.9		 1wopA-3gsiA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ako SPORE COAT PROTEIN A

(Bacillus
subtilis) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 MET A  32
TYR A 139
VAL A  70
VAL A  30
TYR A 141
 None
 1.26A 1wopA-4akoA:
undetectable		 1wopA-4akoA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rya ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL)

(Agrobacterium
vitis) 		PF01547
(SBP_bac_1) 		5 VAL A 341
VAL A 332
TYR A 350
TYR A 355
TYR A 135
 None
None
None
None
MTL  A 501 (-4.5A)
 1.41A 1wopA-4ryaA:
0.0		 1wopA-4ryaA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III

(Methanococcoides
burtonii) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 MET A 217
VAL A 210
VAL A 213
TYR A 206
TYR A 259
 None
 1.33A 1wopA-5macA:
0.4		 1wopA-5macA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj1 DNA TOPOISOMERASE 1

(Mycobacterium
tuberculosis) 		no annotation 5 VAL A 566
TYR A 549
VAL A 562
ASN A 642
TYR A 174
 None
 1.41A 1wopA-5uj1A:
undetectable		 1wopA-5uj1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d7w MYELOPEROXIDASE

(Homo sapiens) 		PF03098
(An_peroxidase) 		3 ASP C 142
GLU C 408
ARG C 403
 None
 0.85A 1wopA-1d7wC:
0.0		 1wopA-1d7wC:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dms DMSO REDUCTASE

(Rhodobacter
capsulatus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		3 ASP A 629
GLU A 760
ARG A 693
 None
 0.88A 1wopA-1dmsA:
0.0		 1wopA-1dmsA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ef7 CATHEPSIN X

(Homo sapiens) 		PF00112
(Peptidase_C1) 		3 ASP A 191
GLU A 208
ARG A 160
 None
 0.79A 1wopA-1ef7A:
0.0		 1wopA-1ef7A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n71 AAC(6')-II

(Enterococcus
faecium) 		PF00583
(Acetyltransf_1) 		3 ASP A  54
GLU A  79
ARG A  90
 None
 0.88A 1wopA-1n71A:
0.0		 1wopA-1n71A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tz7 4-ALPHA-GLUCANOTRANS
FERASE

(Aquifex
aeolicus) 		PF02446
(Glyco_hydro_77) 		3 ASP A 242
GLU A 333
ARG A 343
 None
 0.74A 1wopA-1tz7A:
undetectable		 1wopA-1tz7A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uxi MALATE DEHYDROGENASE

(Chloroflexus
aurantiacus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 ASP A  90
GLU A 178
ARG A 151
 None
None
FUM  A1311 (-2.8A)
 0.68A 1wopA-1uxiA:
0.0		 1wopA-1uxiA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uz8 IGG FAB (IGG3,
KAPPA) HEAVY CHAIN
291-2G3-A

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 ASP B 101
GLU B   6
ARG B  71
 None
 0.86A 1wopA-1uz8B:
0.6		 1wopA-1uz8B:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w45 ANNEXIN A8

(Homo sapiens) 		PF00191
(Annexin) 		3 ASP A 287
GLU A  98
ARG A  56
 None
 0.85A 1wopA-1w45A:
0.0		 1wopA-1w45A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa5 IMPORTIN ALPHA
SUBUNIT
IMPORTIN ALPHA
RE-EXPORTER

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00514
(Arm)
PF01749
(IBB)
PF16186
(Arm_3)
PF03378
(CAS_CSE1)
PF03810
(IBN_N)
PF08506
(Cse1) 		3 ASP B  49
GLU C 226
ARG C 159
 None
 0.59A 1wopA-1wa5B:
0.0		 1wopA-1wa5B:
20.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wop AMINOMETHYLTRANSFERA
SE

(Thermotoga
maritima) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		3 ASP A  96
GLU A 195
ARG A 362
 FFO  A2887 (-3.1A)
FFO  A2887 (-2.8A)
FFO  A2887 (-3.4A)
 0.00A 1wopA-1wopA:
65.4		 1wopA-1wopA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a5l TRP REPRESSOR
BINDING PROTEIN WRBA

(Pseudomonas
aeruginosa) 		PF03358
(FMN_red) 		3 ASP A 169
GLU A 178
ARG A  22
 None
 0.86A 1wopA-2a5lA:
undetectable		 1wopA-2a5lA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ako GLUTAMATE 5-KINASE

(Campylobacter
jejuni) 		PF00696
(AA_kinase) 		3 ASP A 242
GLU A 251
ARG A 180
 None
 0.61A 1wopA-2akoA:
undetectable		 1wopA-2akoA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bqx INORGANIC
PYROPHOSPHATASE

(Helicobacter
pylori) 		PF00719
(Pyrophosphatase) 		3 ASP A  64
GLU A  20
ARG A  42
 None
 0.75A 1wopA-2bqxA:
undetectable		 1wopA-2bqxA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2br4 CEPHALOSPORIN
HYDROXYLASE CMCI

(Streptomyces
clavuligerus) 		PF04989
(CmcI) 		3 ASP A 187
GLU A  87
ARG A 121
 MG  A 300 (-3.3A)
SAM  A 301 (-3.0A)
SAM  A 301 (-3.1A)
 0.88A 1wopA-2br4A:
undetectable		 1wopA-2br4A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g9d SUCCINYLGLUTAMATE
DESUCCINYLASE

(Vibrio cholerae) 		PF04952
(AstE_AspA) 		3 ASP A 274
GLU A 291
ARG A 264
 None
 0.87A 1wopA-2g9dA:
undetectable		 1wopA-2g9dA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzh RAS-RELATED PROTEIN
RAB-11A
RAB11-FIP2 LONG
ISOFORM

(Homo sapiens;
Homo sapiens) 		PF00071
(Ras)
PF09457
(RBD-FIP) 		3 ASP B 482
GLU A 108
ARG A  82
 None
MG  A 951 (-4.5A)
None
 0.89A 1wopA-2gzhB:
undetectable		 1wopA-2gzhB:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i32 ANTI-SILENCING
FACTOR 1 PARALOG A
HISTONE REGULATORY
HOMOLOG A

(Homo sapiens;
Homo sapiens) 		PF04729
(ASF1_hist_chap)
PF09453
(HIRA_B) 		3 ASP A  77
GLU E 451
ARG E 458
 None
 0.83A 1wopA-2i32A:
undetectable		 1wopA-2i32A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuk SEED LIPOXYGENASE

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		3 ASP A 276
GLU A 794
ARG A 265
 None
 0.76A 1wopA-2iukA:
1.6		 1wopA-2iukA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kua BCL-2-LIKE PROTEIN
10

(Mus musculus) 		PF00452
(Bcl-2) 		3 ASP A   3
GLU A  10
ARG A 142
 None
 0.85A 1wopA-2kuaA:
undetectable		 1wopA-2kuaA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3b NUCLEASE
SUGAR-NON-SPECIFIC
NUCLEASE INHIBITOR

(Nostoc sp. PCC
7120;
Nostoc sp. PCC
7120) 		PF01223
(Endonuclease_NS)
PF07924
(NuiA) 		3 ASP A 130
GLU B  24
ARG A  98
 None
MG  A 303 ( 4.0A)
None
 0.78A 1wopA-2o3bA:
undetectable		 1wopA-2o3bA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pjr PROTEIN (HELICASE
PCRA)
PROTEIN (HELICASE
PCRA)

(Geobacillus
stearothermophilus;
Geobacillus
stearothermophilus) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C)
PF13361
(UvrD_C) 		3 ASP B 594
GLU B 640
ARG A 359
 None
 0.73A 1wopA-2pjrB:
undetectable		 1wopA-2pjrB:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rb7 PEPTIDASE,
M20/M25/M40 FAMILY

(Desulfovibrio
alaskensis) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		3 ASP A 100
GLU A 173
ARG A 277
 None
 0.75A 1wopA-2rb7A:
undetectable		 1wopA-2rb7A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vro ALDEHYDE
DEHYDROGENASE

(Paraburkholderia
xenovorans) 		PF00171
(Aldedh) 		3 ASP A 101
GLU A 257
ARG A 300
 None
 0.82A 1wopA-2vroA:
undetectable		 1wopA-2vroA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9y IMITATION SWITCH
PROTEIN 1
(DEL_ATPASE)
ISWI ONE COMPLEX
PROTEIN 3

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF09110
(HAND)
PF09111
(SLIDE)
PF15612
(WHIM1) 		3 ASP B 548
GLU A 995
ARG A1035
 None
 0.72A 1wopA-2y9yB:
undetectable		 1wopA-2y9yB:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE

(Micrococcus
luteus) 		PF00348
(polyprenyl_synt) 		3 ASP B 212
GLU B 146
ARG B  48
 None
2DE  B 329 (-3.9A)
None
 0.77A 1wopA-3aqcB:
undetectable		 1wopA-3aqcB:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d0q PROTEIN CALG3

(Micromonospora
echinospora) 		PF06722
(DUF1205) 		3 ASP A  81
GLU A 183
ARG A 320
 None
 0.78A 1wopA-3d0qA:
undetectable		 1wopA-3d0qA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6n ASPARTATE
CARBAMOYLTRANSFERASE

(Aquifex
aeolicus) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 ASP B 258
GLU B 217
ARG B  97
 None
None
FLC  B 292 (-2.8A)
 0.87A 1wopA-3d6nB:
undetectable		 1wopA-3d6nB:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0s UNCHARACTERIZED
PROTEIN

(Chlorobaculum
tepidum) 		PF05235
(CHAD) 		3 ASP A 254
GLU A 422
ARG A 411
 None
 0.88A 1wopA-3e0sA:
undetectable		 1wopA-3e0sA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e4p C4-DICARBOXYLATE
TRANSPORT SENSOR
PROTEIN DCTB

(Sinorhizobium
meliloti) 		no annotation 3 ASP A 206
GLU A 119
ARG A 175
 None
 0.72A 1wopA-3e4pA:
undetectable		 1wopA-3e4pA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo sapiens) 		PF00233
(PDEase_I) 		3 ASP A 801
GLU A 575
ARG A 524
 None
 0.66A 1wopA-3ecnA:
undetectable		 1wopA-3ecnA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eiz INORGANIC
PYROPHOSPHATASE

(Burkholderia
pseudomallei) 		PF00719
(Pyrophosphatase) 		3 ASP A  66
GLU A  21
ARG A  44
 None
 0.76A 1wopA-3eizA:
undetectable		 1wopA-3eizA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emj INORGANIC
PYROPHOSPHATASE

(Rickettsia
prowazekii) 		PF00719
(Pyrophosphatase) 		3 ASP A  65
GLU A  20
ARG A  43
 None
 0.84A 1wopA-3emjA:
undetectable		 1wopA-3emjA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fzu IMMUNOGLOBULIN IGG1
FAB, HEAVY CHAIN

(Homo sapiens) 		no annotation 3 ASP H 106
GLU H   6
ARG H  74
 None
 0.88A 1wopA-3fzuH:
1.6		 1wopA-3fzuH:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3glg DNA POLYMERASE III
SUBUNIT DELTA

(Escherichia
coli) 		PF06144
(DNA_pol3_delta)
PF14840
(DNA_pol3_delt_C) 		3 ASP A  27
GLU A 239
ARG A 228
 None
 0.86A 1wopA-3glgA:
undetectable		 1wopA-3glgA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h86 ADENYLATE KINASE

(Methanococcus
maripaludis) 		no annotation 3 ASP B 181
GLU B  29
ARG B 192
 None
 0.82A 1wopA-3h86B:
undetectable		 1wopA-3h86B:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3luf TWO-COMPONENT SYSTEM
RESPONSE
REGULATOR/GGDEF
DOMAIN PROTEIN

(Aeromonas
salmonicida) 		PF00072
(Response_reg) 		3 ASP A  10
GLU A  63
ARG A  71
 MG  A 301 (-2.6A)
None
None
 0.70A 1wopA-3lufA:
undetectable		 1wopA-3lufA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5a PERIPLASMIC NITRATE
REDUCTASE

(Cupriavidus
necator) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		3 ASP A 617
GLU A 415
ARG A 400
 None
None
FMT  A 803 (-4.0A)
 0.88A 1wopA-3o5aA:
undetectable		 1wopA-3o5aA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE

(Escherichia
coli) 		PF03738
(GSP_synth)
PF05257
(CHAP) 		3 ASP A 334
GLU A 392
ARG A 598
 None
 0.78A 1wopA-3o98A:
undetectable		 1wopA-3o98A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis) 		PF00348
(polyprenyl_synt) 		3 ASP A 216
GLU A 150
ARG A  50
 None
None
CIT  A 326 (-2.6A)
 0.84A 1wopA-3pkoA:
undetectable		 1wopA-3pkoA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvj ALPHA-KETOGLUTARATE-
DEPENDENT TAURINE
DIOXYGENASE

(Pseudomonas
putida) 		PF02668
(TauD) 		3 ASP A  64
GLU A  34
ARG A 188
 None
 0.67A 1wopA-3pvjA:
undetectable		 1wopA-3pvjA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qc1 IMMUNOGLOBULIN-BINDI
NG PROTEIN 1

(Mus musculus) 		PF04177
(TAP42) 		3 ASP A  26
GLU A 181
ARG A 200
 None
 0.83A 1wopA-3qc1A:
undetectable		 1wopA-3qc1A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swx PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus) 		PF00378
(ECH_1) 		3 ASP A  93
GLU A 115
ARG A 152
 None
 0.85A 1wopA-3swxA:
undetectable		 1wopA-3swxA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Toxoplasma
gondii) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		3 ASP A 107
GLU A 183
ARG A 156
 None
 0.88A 1wopA-3sxfA:
undetectable		 1wopA-3sxfA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vc1 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E

(Streptomyces
coelicolor) 		PF08241
(Methyltransf_11) 		3 ASP A  42
GLU A 142
ARG A 117
 None
 0.88A 1wopA-3vc1A:
undetectable		 1wopA-3vc1A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9v PHOSPHATE-BINDING
PROTEIN

(unidentified
prokaryotic
organism) 		PF12849
(PBP_like_2) 		3 ASP A 224
GLU A 243
ARG A 131
 None
 0.86A 1wopA-3w9vA:
undetectable		 1wopA-3w9vA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b0t PUP--PROTEIN LIGASE

(Corynebacterium
glutamicum) 		PF03136
(Pup_ligase) 		3 ASP A 208
GLU A  70
ARG A 422
 ADP  A1478 (-4.4A)
MG  A1479 ( 4.0A)
None
 0.74A 1wopA-4b0tA:
undetectable		 1wopA-4b0tA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3o HYDROGENASE-1 LARGE
SUBUNIT

(Salmonella
enterica) 		PF00374
(NiFeSe_Hases) 		3 ASP A 118
GLU A  73
ARG A  89
 None
 0.73A 1wopA-4c3oA:
undetectable		 1wopA-4c3oA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cit VANADIUM-DEPENDENT
HALOPEROXIDASE

(Zobellia
galactanivorans) 		PF01569
(PAP2) 		3 ASP A 153
GLU A 119
ARG A  56
 None
 0.80A 1wopA-4citA:
undetectable		 1wopA-4citA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4esw PYRIMIDINE
BIOSYNTHESIS ENZYME
THI13

(Candida
albicans) 		PF09084
(NMT1) 		3 ASP A 312
GLU A  86
ARG A 277
 None
 0.76A 1wopA-4eswA:
undetectable		 1wopA-4eswA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgo PERIPLASMIC PROTEIN

(Legionella
pneumophila) 		PF06035
(Peptidase_C93) 		3 ASP A 136
GLU A 128
ARG A  78
 CA  A 301 (-2.6A)
None
None
 0.83A 1wopA-4fgoA:
undetectable		 1wopA-4fgoA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gp1 POLYPRENYL
SYNTHETASE

(Pyrobaculum
calidifontis) 		PF00348
(polyprenyl_synt) 		3 ASP A 226
GLU A 148
ARG A  49
 None
None
DMA  A 402 (-3.1A)
 0.83A 1wopA-4gp1A:
undetectable		 1wopA-4gp1A:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0f LAMININ-BINDING
SURFACE PROTEIN

(Streptococcus
agalactiae) 		PF01297
(ZnuA) 		3 ASP A 140
GLU A 153
ARG A  96
 None
 0.84A 1wopA-4h0fA:
undetectable		 1wopA-4h0fA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h3v OXIDOREDUCTASE
DOMAIN PROTEIN

(Kribbella
flavida) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 ASP A 182
GLU A 374
ARG A 266
 None
 0.65A 1wopA-4h3vA:
undetectable		 1wopA-4h3vA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ikb SORTING NEXIN-11

(Homo sapiens) 		PF00787
(PX) 		3 ASP B  93
GLU B  29
ARG B  57
 None
 0.87A 1wopA-4ikbB:
undetectable		 1wopA-4ikbB:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j8f HEAT SHOCK 70 KDA
PROTEIN 1A/1B,
HSC70-INTERACTING
PROTEIN

(Homo sapiens;
Rattus
norvegicus) 		PF00012
(HSP70) 		3 ASP A  32
GLU A  48
ARG A 479
 None
 0.72A 1wopA-4j8fA:
undetectable		 1wopA-4j8fA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcs ENOYL-COA
HYDRATASE/ISOMERASE

(Cupriavidus
metallidurans) 		PF00378
(ECH_1) 		3 ASP A 169
GLU A 160
ARG A 136
 None
 0.82A 1wopA-4jcsA:
undetectable		 1wopA-4jcsA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhj MIF4G
DOMAIN-CONTAINING
PROTEIN B

(Danio rerio) 		PF02854
(MIF4G) 		3 ASP A 160
GLU A 197
ARG A 178
 None
 0.81A 1wopA-4jhjA:
undetectable		 1wopA-4jhjA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mt1 DRUG EFFLUX PROTEIN

(Neisseria
gonorrhoeae) 		PF00873
(ACR_tran) 		3 ASP A 406
GLU A 955
ARG A 416
 None
 0.71A 1wopA-4mt1A:
3.5		 1wopA-4mt1A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 CALCIUM-BINDING
PROTEIN 39
SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens;
Homo sapiens) 		PF08569
(Mo25)
PF00069
(Pkinase) 		3 ASP B  66
GLU A 235
ARG A 313
 None
 0.74A 1wopA-4o27B:
undetectable		 1wopA-4o27B:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		3 ASP A 999
GLU A1502
ARG A1545
 None
 0.78A 1wopA-4o9xA:
undetectable		 1wopA-4o9xA:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p7h MYOSIN-7,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Homo sapiens) 		PF00063
(Myosin_head)
PF01353
(GFP)
PF02736
(Myosin_N) 		3 ASP A 469
GLU A 677
ARG A 243
 None
 0.88A 1wopA-4p7hA:
undetectable		 1wopA-4p7hA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		3 ASP A 563
GLU A 571
ARG A 521
 None
 0.71A 1wopA-4po0A:
undetectable		 1wopA-4po0A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pu6 L-ASPARAGINASE ALPHA
SUBUNIT

(Phaseolus
vulgaris) 		PF01112
(Asparaginase_2) 		3 ASP A 146
GLU A  21
ARG A  32
 None
 0.85A 1wopA-4pu6A:
undetectable		 1wopA-4pu6A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1l SNAKE VENOM
METALLOPROTEINASE
LEUCUROLYSIN-A

(Bothrops
leucurus) 		PF01421
(Reprolysin) 		3 ASP A 153
GLU A 143
ARG A 135
 None
ZN  A 302 ( 4.7A)
None
 0.86A 1wopA-4q1lA:
undetectable		 1wopA-4q1lA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q66 PROTEIN BCH1

(Saccharomyces
cerevisiae) 		no annotation 3 ASP K 256
GLU K 383
ARG K 308
 None
 0.88A 1wopA-4q66K:
undetectable		 1wopA-4q66K:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qg5 PUTATIVE
PHOSPHOGLUCOMUTASE

(Leishmania
major) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		3 ASP A 260
GLU A 458
ARG A 523
 None
 0.81A 1wopA-4qg5A:
0.7		 1wopA-4qg5A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7b CHOLINE KINASE

(Streptococcus
pneumoniae) 		PF01633
(Choline_kinase) 		3 ASP A  98
GLU A 220
ARG A 275
 None
 0.78A 1wopA-4r7bA:
undetectable		 1wopA-4r7bA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN

(Nitratireductor
pacificus) 		PF12838
(Fer4_7)
PF13486
(Dehalogenase) 		3 ASP A 505
GLU A 539
ARG A 278
 None
 0.76A 1wopA-4rasA:
undetectable		 1wopA-4rasA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rwf MALTOSE TRANSPORTER
SUBUNIT, RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 2,
CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
FUSION PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF02793
(HRM)
PF04901
(RAMP)
PF13416
(SBP_bac_8) 		3 ASP A2090
GLU A2047
ARG A1097
 None
EDO  A2205 ( 3.2A)
None
 0.79A 1wopA-4rwfA:
undetectable		 1wopA-4rwfA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rzm EPOXIDE HYDROLASE
LASB

(Streptomyces
lasaliensis) 		PF12680
(SnoaL_2) 		3 ASP A 207
GLU A 116
ARG A  54
 None
 0.86A 1wopA-4rzmA:
undetectable		 1wopA-4rzmA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tmk PROTEIN (THYMIDYLATE
KINASE)

(Escherichia
coli) 		PF02223
(Thymidylate_kin) 		3 ASP A  56
GLU A  12
ARG A 113
 None
T5A  A 214 (-3.7A)
None
 0.79A 1wopA-4tmkA:
undetectable		 1wopA-4tmkA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u4p STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
2
STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
4

(Homo sapiens;
Homo sapiens) 		PF06470
(SMC_hinge)
PF06470
(SMC_hinge) 		3 ASP B 641
GLU A 547
ARG A 668
 None
 0.81A 1wopA-4u4pB:
undetectable		 1wopA-4u4pB:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upl SULFATASE FAMILY
PROTEIN

(Ruegeria
pomeroyi) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		3 ASP A 146
GLU A 203
ARG A 158
 None
 0.88A 1wopA-4uplA:
undetectable		 1wopA-4uplA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yyf BETA-N-ACETYLHEXOSAM
INIDASE

(Mycolicibacterium
smegmatis) 		PF00933
(Glyco_hydro_3) 		3 ASP A 236
GLU A 128
ARG A 146
 None
 0.78A 1wopA-4yyfA:
undetectable		 1wopA-4yyfA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgv FERREDOXIN RECEPTOR

(Pectobacterium
atrosepticum) 		PF07715
(Plug) 		3 ASP A 198
GLU A 444
ARG A 544
 None
 0.85A 1wopA-4zgvA:
undetectable		 1wopA-4zgvA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zlr BRAIN TUMOR PROTEIN

(Drosophila
melanogaster) 		PF01436
(NHL) 		3 ASP A 880
GLU A 944
ARG A 949
 None
 0.64A 1wopA-4zlrA:
undetectable		 1wopA-4zlrA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxl O-GLCNACASE NAGJ

(Clostridium
perfringens) 		PF02838
(Glyco_hydro_20b)
PF07555
(NAGidase) 		3 ASP A 474
GLU A 528
ARG A 495
 CD  A 715 (-2.2A)
None
None
 0.87A 1wopA-4zxlA:
undetectable		 1wopA-4zxlA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3f DYNAMIN 3

(Homo sapiens) 		PF00169
(PH)
PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED) 		3 ASP A 241
GLU A  79
ARG A  98
 None
 0.80A 1wopA-5a3fA:
undetectable		 1wopA-5a3fA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b01 MOEN5

(Streptomyces
viridosporus) 		no annotation 3 ASP A  71
GLU A 195
ARG A 129
 None
 0.87A 1wopA-5b01A:
undetectable		 1wopA-5b01A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bq1 CARBONIC ANHYDRASE

(Pseudomonas
aeruginosa) 		PF00484
(Pro_CA) 		3 ASP A 186
GLU A 149
ARG A 105
 None
 0.85A 1wopA-5bq1A:
undetectable		 1wopA-5bq1A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bvi INTERFERON
REGULATORY FACTOR 4

(Mus musculus) 		PF10401
(IRF-3) 		3 ASP A 337
GLU A 367
ARG A 411
 None
 0.87A 1wopA-5bviA:
undetectable		 1wopA-5bviA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cov NAEGLERIA GRUBERI
RNA LIGASE

(Naegleria
gruberi) 		PF09414
(RNA_ligase) 		3 ASP A 183
GLU A 193
ARG A 207
 None
 0.88A 1wopA-5covA:
undetectable		 1wopA-5covA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cuy ACIDOCALCISOMAL
PYROPHOSPHATASE

(Trypanosoma
brucei) 		PF00719
(Pyrophosphatase) 		3 ASP A 291
GLU A 229
ARG A 259
 MG  A 902 (-3.2A)
None
None
 0.77A 1wopA-5cuyA:
undetectable		 1wopA-5cuyA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cuy ACIDOCALCISOMAL
PYROPHOSPHATASE

(Trypanosoma
brucei) 		PF00719
(Pyrophosphatase) 		3 ASP A 328
GLU A 229
ARG A 259
 MG  A 902 (-4.3A)
None
None
 0.78A 1wopA-5cuyA:
undetectable		 1wopA-5cuyA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dxw PD-L1 NANOBODY

(Mus musculus) 		PF07686
(V-set) 		3 ASP A 104
GLU A   8
ARG A  74
 None
 0.63A 1wopA-5dxwA:
undetectable		 1wopA-5dxwA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ed1 DOUBLE-STRANDED
RNA-SPECIFIC EDITASE
1

(Homo sapiens) 		PF02137
(A_deamin) 		3 ASP A 606
GLU A 412
ARG A 423
 None
 0.60A 1wopA-5ed1A:
undetectable		 1wopA-5ed1A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eeb ALDEHYDE
DEHYDROGENASE

(Pyrobaculum
ferrireducens) 		PF00171
(Aldedh) 		3 ASP A 472
GLU A 463
ARG A  70
 None
 0.82A 1wopA-5eebA:
undetectable		 1wopA-5eebA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hpk E3 UBIQUITIN-PROTEIN
LIGASE NEDD4-LIKE

(Homo sapiens) 		PF00632
(HECT) 		3 ASP A 728
GLU A 829
ARG A 877
 None
 0.81A 1wopA-5hpkA:
undetectable		 1wopA-5hpkA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i1f UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE

(Burkholderia
vietnamiensis) 		PF00483
(NTP_transferase) 		3 ASP A 133
GLU A 228
ARG A  59
 MG  A 303 ( 2.6A)
MG  A 302 ( 3.9A)
None
 0.61A 1wopA-5i1fA:
undetectable		 1wopA-5i1fA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ja9 NANOBODY 6

(Lama glama) 		PF07686
(V-set) 		3 ASP A 106
GLU A   7
ARG A  73
 None
 0.82A 1wopA-5ja9A:
1.9		 1wopA-5ja9A:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1u NAD(P)H:FLAVIN
OXIDOREDUCTASE SYE4

(Shewanella
oneidensis) 		PF00724
(Oxidored_FMN) 		3 ASP A  40
GLU A  65
ARG A 140
 None
 0.88A 1wopA-5k1uA:
undetectable		 1wopA-5k1uA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odr HETERODISULFIDE
REDUCTASE, SUBUNIT A
METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
G

(Methanothermococcus
thermolithotrophicus;
Methanothermococcus
thermolithotrophicus) 		PF07992
(Pyr_redox_2)
PF13187
(Fer4_9)
PF01058
(Oxidored_q6) 		3 ASP E 247
GLU E 138
ARG A 651
 None
 0.86A 1wopA-5odrE:
undetectable		 1wopA-5odrE:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wna MAB 3D3 FAB HEAVY
CHAIN

(Homo sapiens) 		no annotation 3 ASP H 112
GLU H   6
ARG H  72
 None
 0.80A 1wopA-5wnaH:
2.0		 1wopA-5wnaH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xqo PCRGLX PROTEIN

(Penicillium
chrysogenum) 		no annotation 3 ASP A 711
GLU A 587
ARG A 845
 None
ADA  A1004 ( 3.7A)
None
 0.81A 1wopA-5xqoA:
undetectable		 1wopA-5xqoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xsy SODIUM CHANNEL
PROTEIN

(Electrophorus
electricus) 		PF00520
(Ion_trans)
PF06512
(Na_trans_assoc) 		3 ASP A 307
GLU A 301
ARG A 335
 None
 0.54A 1wopA-5xsyA:
undetectable		 1wopA-5xsyA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ya1 AUTOINDUCER-2 KINASE

(Escherichia
coli) 		no annotation 3 ASP A 186
GLU A 308
ARG A 150
 None
 0.81A 1wopA-5ya1A:
undetectable		 1wopA-5ya1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bxn DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2

(Candidatus
Methanoperedens
nitroreducens) 		no annotation 3 ASP A 263
GLU A  29
ARG A 293
 None
 0.56A 1wopA-6bxnA:
undetectable		 1wopA-6bxnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ca6 PCT64_35S HEAVY
CHAIN

(Homo sapiens) 		no annotation 3 ASP H 101
GLU H   6
ARG H  71
 None
 0.79A 1wopA-6ca6H:
undetectable		 1wopA-6ca6H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ehe OMPT PROTEIN

(Vibrio cholerae) 		no annotation 3 ASP A  93
GLU A  57
ARG A 282
 C8E  A 407 (-3.8A)
None
ACT  A 410 ( 4.6A)
 0.88A 1wopA-6eheA:
undetectable		 1wopA-6eheA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ejm SINGLE CHAIN FV
FRAGMENT

(Mus musculus) 		no annotation 3 ASP H 142
GLU H  44
ARG H 110
 None
 0.65A 1wopA-6ejmH:
1.7		 1wopA-6ejmH:
undetectable