SIMILAR PATTERNS OF AMINO ACIDS FOR 1WG8_B_SAMB3141_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1arl APO-CARBOXYPEPTIDASE
A=ALPHA= (COX)

(Bos taurus) 		PF00246
(Peptidase_M14) 		3 HIS A 166
ASP A 148
ASN A 260
 None
 0.71A 1wg8B-1arlA:
undetectable		 1wg8B-1arlA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cbk PROTEIN
(7,8-DIHYDRO-6-HYDRO
XYMETHYLPTERIN-PYROP
HOSPHOKINASE)

(Haemophilus
influenzae) 		PF01288
(HPPK) 		3 HIS A 115
ASP A  95
ASN A  11
 None
ROI  A 601 (-4.6A)
None
 0.68A 1wg8B-1cbkA:
undetectable		 1wg8B-1cbkA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ddb PROTEIN (BID)

(Mus musculus) 		PF06393
(BID) 		3 HIS A 162
ASP A  98
ASN A 100
 None
 0.77A 1wg8B-1ddbA:
undetectable		 1wg8B-1ddbA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js1 TRANSCARBAMYLASE

(Bacteroides
fragilis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 HIS X 319
ASP X 105
ASN X  64
 None
 0.78A 1wg8B-1js1X:
4.7		 1wg8B-1js1X:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ktw IOTA-CARRAGEENASE

(Alteromonas sp.
ATCC 43554) 		PF12708
(Pectate_lyase_3) 		3 HIS A 235
ASP A 178
ASN A 180
 None
NA  A  13 (-2.2A)
None
 0.83A 1wg8B-1ktwA:
undetectable		 1wg8B-1ktwA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1e MYCOLIC ACID
SYNTHASE

(Mycobacterium
tuberculosis) 		PF02353
(CMAS) 		3 HIS A 102
ASP A  21
ASN A 246
 None
 0.70A 1wg8B-1l1eA:
14.7		 1wg8B-1l1eA:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE

(Saccharomyces
cerevisiae) 		PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5) 		3 HIS A 219
ASP A 189
ASN A 194
 None
 0.78A 1wg8B-1la2A:
4.0		 1wg8B-1la2A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m54 CYSTATHIONINE
BETA-SYNTHASE

(Homo sapiens) 		PF00291
(PALP) 		3 HIS A 203
ASP A 221
ASN A 228
 None
None
PLP  A1110 ( 4.5A)
 0.69A 1wg8B-1m54A:
3.5		 1wg8B-1m54A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mnn NDT80 PROTEIN

(Saccharomyces
cerevisiae) 		PF05224
(NDT80_PhoG) 		3 HIS A 101
ASP A  49
ASN A 330
 None
 0.76A 1wg8B-1mnnA:
undetectable		 1wg8B-1mnnA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pca PROCARBOXYPEPTIDASE
A PCPA

(Sus scrofa) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		3 HIS A 166
ASP A 148
ASN A 260
 None
 0.72A 1wg8B-1pcaA:
undetectable		 1wg8B-1pcaA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgd PROTEIN
(TRANSKETOLASE)

(Escherichia
coli) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		3 HIS A 192
ASP A 155
ASN A  64
 None
CA  A 675 (-3.3A)
None
 0.86A 1wg8B-1qgdA:
2.8		 1wg8B-1qgdA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ru4 PECTATE LYASE

(Dickeya
chrysanthemi) 		PF13229
(Beta_helix) 		3 HIS A 283
ASP A 299
ASN A 268
 None
 0.88A 1wg8B-1ru4A:
undetectable		 1wg8B-1ru4A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vgm 378AA LONG
HYPOTHETICAL CITRATE
SYNTHASE

(Sulfurisphaera
tokodaii) 		PF00285
(Citrate_synt) 		3 HIS A 184
ASP A  35
ASN A  41
 None
 0.72A 1wg8B-1vgmA:
undetectable		 1wg8B-1vgmA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vqv THIAMINE
MONOPHOSPHATE KINASE

(Aquifex
aeolicus) 		PF00586
(AIRS) 		3 HIS A 218
ASP A 207
ASN A  68
 None
 0.71A 1wg8B-1vqvA:
undetectable		 1wg8B-1vqvA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w18 LEVANSUCRASE

(Gluconacetobacter
diazotrophicus) 		PF02435
(Glyco_hydro_68) 		3 HIS A 486
ASP A 309
ASN A 306
 None
 0.86A 1wg8B-1w18A:
undetectable		 1wg8B-1w18A:
21.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wg8 PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF01795
(Methyltransf_5) 		3 HIS A  36
ASP A  51
ASN A  74
 SAM  A3142 (-3.9A)
SAM  A3142 (-2.8A)
SAM  A3142 (-3.0A)
 0.15A 1wg8B-1wg8A:
45.8		 1wg8B-1wg8A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9y CYSTEINE PROTEINASE

(Staphylococcus
aureus) 		PF05543
(Peptidase_C47)
PF14731
(Staphopain_pro) 		3 HIS A 340
ASP A 383
ASN A 121
 None
 0.80A 1wg8B-1x9yA:
undetectable		 1wg8B-1x9yA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yy5 FMS1 PROTEIN

(Saccharomyces
cerevisiae) 		PF01593
(Amino_oxidase) 		3 HIS A 109
ASP A  95
ASN A 362
 None
 0.77A 1wg8B-1yy5A:
undetectable		 1wg8B-1yy5A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2die AMYLASE

(Bacillus sp.
(in: Bacteria)) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		3 HIS A 240
ASP A 166
ASN A 175
 None
 0.83A 1wg8B-2dieA:
undetectable		 1wg8B-2dieA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fa0 HMG-COA SYNTHASE

(Brassica juncea) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		3 HIS A 341
ASP A  11
ASN A  59
 None
 0.73A 1wg8B-2fa0A:
undetectable		 1wg8B-2fa0A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)

(Arabidopsis
thaliana) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		3 HIS A 247
ASP A 242
ASN A  58
 None
 0.73A 1wg8B-2fgeA:
undetectable		 1wg8B-2fgeA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuv PHOSPHOGLUCOMUTASE

(Salmonella
enterica) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		3 HIS A 310
ASP A 306
ASN A 148
 None
MG  A 901 (-2.1A)
None
 0.72A 1wg8B-2fuvA:
undetectable		 1wg8B-2fuvA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fyj LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 1

(Homo sapiens) 		PF00057
(Ldl_recept_a) 		3 HIS A  82
ASP A  70
ASN A  62
 None
 0.86A 1wg8B-2fyjA:
undetectable		 1wg8B-2fyjA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmh ELECTRON TRANSFER
FLAVOPROTEIN-UBIQUIN
ONE OXIDOREDUCTASE

(Sus scrofa) 		PF05187
(ETF_QO)
PF13450
(NAD_binding_8) 		3 HIS A 555
ASP A 560
ASN A 567
 None
 0.85A 1wg8B-2gmhA:
3.5		 1wg8B-2gmhA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hwy PROTEIN SMG5

(Homo sapiens) 		PF13638
(PIN_4) 		3 HIS A 899
ASP A 860
ASN A1004
 None
 0.88A 1wg8B-2hwyA:
3.6		 1wg8B-2hwyA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ic2 CG9211-PA

(Drosophila
melanogaster) 		PF00041
(fn3) 		3 HIS A 544
ASP A 539
ASN A 515
 None
 0.84A 1wg8B-2ic2A:
undetectable		 1wg8B-2ic2A:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oys HYPOTHETICAL PROTEIN
SP1951

(Streptococcus
pneumoniae) 		PF03358
(FMN_red) 		3 HIS A 150
ASP A 123
ASN A 132
 None
 0.88A 1wg8B-2oysA:
3.6		 1wg8B-2oysA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q7x UPF0052 PROTEIN
SP_1565

(Streptococcus
pneumoniae) 		PF01933
(UPF0052) 		3 HIS A 233
ASP A 236
ASN A 258
 None
 0.79A 1wg8B-2q7xA:
3.8		 1wg8B-2q7xA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qdr UNCHARACTERIZED
PROTEIN

(Nostoc
punctiforme) 		PF14499
(DUF4437) 		3 HIS A  86
ASP A 285
ASN A 214
 None
 0.63A 1wg8B-2qdrA:
undetectable		 1wg8B-2qdrA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT

(Homo sapiens) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC) 		3 HIS A 179
ASP A 482
ASN A 495
 None
 0.77A 1wg8B-2wghA:
undetectable		 1wg8B-2wghA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z0f PUTATIVE
PHOSPHOGLUCOMUTASE

(Thermus
thermophilus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		3 HIS A 292
ASP A 288
ASN A 132
 None
 0.82A 1wg8B-2z0fA:
undetectable		 1wg8B-2z0fA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ekg MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Azotobacter
vinelandii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 HIS A 147
ASP A 136
ASN A  71
 None
 0.60A 1wg8B-3ekgA:
undetectable		 1wg8B-3ekgA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f70 LETHAL(3)MALIGNANT
BRAIN TUMOR-LIKE 2
PROTEIN

(Homo sapiens) 		PF02820
(MBT) 		3 HIS A 369
ASP A 582
ASN A 528
 None
 0.81A 1wg8B-3f70A:
undetectable		 1wg8B-3f70A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3faw RETICULOCYTE BINDING
PROTEIN

(Streptococcus
agalactiae) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		3 HIS A 807
ASP A 839
ASN A 758
 None
 0.81A 1wg8B-3fawA:
undetectable		 1wg8B-3fawA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g3b VARIABLE LYMPHOCYTE
RECEPTOR VLRB.2D

(Petromyzon
marinus) 		PF01462
(LRRNT)
PF11921
(DUF3439)
PF13855
(LRR_8) 		3 HIS A 105
ASP A  59
ASN A  62
 None
 0.71A 1wg8B-3g3bA:
undetectable		 1wg8B-3g3bA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbw E3 UBIQUITIN-PROTEIN
LIGASE MYCBP2

(Mus musculus) 		PF08005
(PHR) 		3 HIS A1347
ASP A1373
ASN A1370
 None
 0.87A 1wg8B-3gbwA:
undetectable		 1wg8B-3gbwA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h8f CYTOSOL
AMINOPEPTIDASE

(Pseudomonas
putida) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		3 HIS A 175
ASP A 121
ASN A 119
 None
 0.82A 1wg8B-3h8fA:
2.5		 1wg8B-3h8fA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i0m DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1

(Schizosaccharomyces
pombe) 		PF00498
(FHA) 		3 HIS A 150
ASP A 177
ASN A 211
 GOL  A 325 (-4.6A)
None
None
 0.78A 1wg8B-3i0mA:
undetectable		 1wg8B-3i0mA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ixw HEMOCYANIN AA6 CHAIN

(Androctonus
australis) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 HIS A 560
ASP A 484
ASN A 500
 None
 0.87A 1wg8B-3ixwA:
undetectable		 1wg8B-3ixwA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7a 40S RIBOSOMAL
PROTEIN US2

(Plasmodium
falciparum) 		PF00318
(Ribosomal_S2) 		3 HIS C  23
ASP C 148
ASN C  28
 None
 0.68A 1wg8B-3j7aC:
undetectable		 1wg8B-3j7aC:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6j PROTEIN F01G10.3,
CONFIRMED BY
TRANSCRIPT EVIDENCE

(Caenorhabditis
elegans) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		3 HIS A  31
ASP A 371
ASN A 366
 None
 0.87A 1wg8B-3k6jA:
6.8		 1wg8B-3k6jA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k96 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]

(Coxiella
burnetii) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		3 HIS A   6
ASP A 164
ASN A 158
 None
 0.85A 1wg8B-3k96A:
6.0		 1wg8B-3k96A:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o6x GLUTAMINE SYNTHETASE

(Bacteroides
fragilis) 		PF00120
(Gln-synt_C)
PF12437
(GSIII_N) 		3 HIS A  89
ASP A 178
ASN A 481
 None
 0.87A 1wg8B-3o6xA:
undetectable		 1wg8B-3o6xA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oc9 UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE

(Entamoeba
histolytica) 		PF01704
(UDPGP) 		3 HIS A 153
ASP A 183
ASN A 334
 None
 0.64A 1wg8B-3oc9A:
undetectable		 1wg8B-3oc9A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		3 HIS A 110
ASP A 300
ASN A 296
 None
 0.86A 1wg8B-3oz6A:
undetectable		 1wg8B-3oz6A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p2c PUTATIVE GLYCOSYL
HYDROLASE

(Bacteroides
ovatus) 		PF06824
(Glyco_hydro_125) 		3 HIS A  91
ASP A 116
ASN A 156
 None
 0.78A 1wg8B-3p2cA:
undetectable		 1wg8B-3p2cA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p4g ANTIFREEZE PROTEIN

(Marinomonas
primoryensis) 		no annotation 3 HIS A 305
ASP A 259
ASN A 218
 None
CA  A 411 ( 2.3A)
None
 0.84A 1wg8B-3p4gA:
undetectable		 1wg8B-3p4gA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pig BETA-FRUCTOFURANOSID
ASE

(Bifidobacterium
longum) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		3 HIS A  72
ASP A 110
ASN A 136
 None
 0.88A 1wg8B-3pigA:
undetectable		 1wg8B-3pigA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qlb ENANTIO-PYOCHELIN
RECEPTOR

(Pseudomonas
fluorescens) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 HIS A 304
ASP A 276
ASN A 310
 None
 0.79A 1wg8B-3qlbA:
undetectable		 1wg8B-3qlbA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qlj SHORT CHAIN
DEHYDROGENASE

(Mycobacterium
avium) 		PF00106
(adh_short) 		3 HIS A  22
ASP A  37
ASN A  73
 None
 0.53A 1wg8B-3qljA:
8.4		 1wg8B-3qljA:
26.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sop NEURONAL-SPECIFIC
SEPTIN-3

(Homo sapiens) 		PF00735
(Septin) 		3 HIS A 183
ASP A 189
ASN A 135
 None
 0.80A 1wg8B-3sopA:
2.3		 1wg8B-3sopA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wd8 TYPE III POLYKETIDE
SYNTHASE QUINOLONE
SYNTHASE

(Citrus x
microcarpa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		3 HIS A 126
ASP A 141
ASN A 146
 None
 0.86A 1wg8B-3wd8A:
undetectable		 1wg8B-3wd8A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ako SPORE COAT PROTEIN A

(Bacillus
subtilis) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A  86
ASP A 499
ASN A 259
 None
 0.61A 1wg8B-4akoA:
undetectable		 1wg8B-4akoA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4auk RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M

(Escherichia
coli) 		PF01728
(FtsJ) 		3 HIS A 197
ASP A 206
ASN A 211
 None
 0.86A 1wg8B-4aukA:
12.8		 1wg8B-4aukA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3i FATTY ACID
BETA-OXIDATION
COMPLEX ALPHA-CHAIN
FADB
FATTY ACID
BETA-OXIDATION
COMPLEX BETA-CHAIN
FADA

(Mycobacterium
tuberculosis;
Mycobacterium
tuberculosis) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		3 HIS A -11
ASP A 277
ASN C  20
 None
 0.85A 1wg8B-4b3iA:
6.6		 1wg8B-4b3iA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dfs GLYCOSIDE HYDROLASE,
FAMILY 16

(Thermotoga
petrophila) 		PF00722
(Glyco_hydro_16) 		3 HIS A 179
ASP A 249
ASN A  60
 None
CA  A 301 (-3.1A)
None
 0.77A 1wg8B-4dfsA:
undetectable		 1wg8B-4dfsA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e84 D-BETA-D-HEPTOSE
7-PHOSPHATE KINASE

(Burkholderia
cenocepacia) 		PF00294
(PfkB) 		3 HIS A 316
ASP A 310
ASN A  66
 None
 0.84A 1wg8B-4e84A:
6.1		 1wg8B-4e84A:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN

(Schizosaccharomyces
pombe) 		PF00149
(Metallophos)
PF04152
(Mre11_DNA_bind) 		3 HIS A1228
ASP A1191
ASN A1133
 None
None
MN  A1501 (-2.5A)
 0.88A 1wg8B-4fbqA:
undetectable		 1wg8B-4fbqA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fjo MITOTIC SPINDLE
ASSEMBLY CHECKPOINT
PROTEIN MAD2B

(Mus musculus) 		PF02301
(HORMA) 		3 HIS C 180
ASP C  89
ASN C 210
 PO4  C 302 ( 3.8A)
None
None
 0.81A 1wg8B-4fjoC:
undetectable		 1wg8B-4fjoC:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwm PROPIONATE KINASE

(Salmonella
enterica) 		PF00871
(Acetate_kinase) 		3 HIS A 360
ASP A 350
ASN A 368
 None
 0.83A 1wg8B-4fwmA:
2.3		 1wg8B-4fwmA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ixu ARGINASE-2,
MITOCHONDRIAL

(Homo sapiens) 		PF00491
(Arginase) 		3 HIS A  44
ASP A 119
ASN A 158
 None
 0.84A 1wg8B-4ixuA:
undetectable		 1wg8B-4ixuA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jz5 GP26

(Listeria phage
P40) 		PF01183
(Glyco_hydro_25) 		3 HIS A 138
ASP A  96
ASN A  32
 None
 0.84A 1wg8B-4jz5A:
undetectable		 1wg8B-4jz5A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k2u ERYTHROCYTE BINDING
ANTIGEN 175
ANTIBODY HEAVY CHAIN

(Plasmodium
falciparum;
Mus musculus) 		PF03011
(PFEMP)
PF05424
(Duffy_binding)
PF07654
(C1-set)
PF07686
(V-set) 		3 HIS A 159
ASP H  52
ASN H  32
 None
None
SO4  H 301 ( 4.8A)
 0.68A 1wg8B-4k2uA:
undetectable		 1wg8B-4k2uA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l8n PDZ DOMAIN PROTEIN

(Parabacteroides
distasonis) 		PF00595
(PDZ)
PF13590
(DUF4136) 		3 HIS A 300
ASP A 294
ASN A 176
 None
 0.86A 1wg8B-4l8nA:
undetectable		 1wg8B-4l8nA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lcv DOUBLE C2-LIKE
DOMAIN-CONTAINING
PROTEIN BETA

(Rattus
norvegicus) 		PF00168
(C2) 		3 HIS A 242
ASP A 137
ASN A 141
 None
 0.83A 1wg8B-4lcvA:
undetectable		 1wg8B-4lcvA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lix ENT-COPALYL
DIPHOSPHATE
SYNTHASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		3 HIS A 263
ASP A 380
ASN A 425
 AG8  A 901 (-3.9A)
AG8  A 901 ( 3.7A)
None
 0.86A 1wg8B-4lixA:
undetectable		 1wg8B-4lixA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbq POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Coxiella
burnetii) 		PF00013
(KH_1)
PF00575
(S1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		3 HIS A 406
ASP A  95
ASN A  61
 SO4  A 701 ( 4.9A)
None
None
 0.87A 1wg8B-4nbqA:
undetectable		 1wg8B-4nbqA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata) 		PF01580
(FtsK_SpoIIIE) 		3 HIS A1161
ASP A1155
ASN A1124
 None
None
ATP  A1404 (-3.5A)
 0.86A 1wg8B-4nh0A:
3.3		 1wg8B-4nh0A:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8q COATOMER SUBUNIT
DELTA

(Bos taurus) 		PF00928
(Adap_comp_sub) 		3 HIS A 316
ASP A 334
ASN A 348
 None
 0.83A 1wg8B-4o8qA:
undetectable		 1wg8B-4o8qA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qri HYPOXANTHINE-GUANINE
-XANTHINE
PHOSPHORIBOSYLTRANSF
ERASE

(Leptospira
interrogans) 		PF00156
(Pribosyltran) 		3 HIS A  10
ASP A 170
ASN A 167
 None
 0.80A 1wg8B-4qriA:
undetectable		 1wg8B-4qriA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r85 CYTOSINE DEAMINASE

(Klebsiella
pneumoniae) 		PF07969
(Amidohydro_3) 		3 HIS A 117
ASP A 312
ASN A  71
 None
17E  A 501 ( 4.4A)
None
 0.69A 1wg8B-4r85A:
undetectable		 1wg8B-4r85A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvw ZNUD

(Neisseria
meningitidis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 HIS A 677
ASP A 702
ASN A 160
 None
 0.86A 1wg8B-4rvwA:
undetectable		 1wg8B-4rvwA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tpv PLATELET INHIBITOR

(Ancylostoma
caninum) 		PF00188
(CAP) 		3 HIS A 183
ASP A 172
ASN A 175
 None
 0.80A 1wg8B-4tpvA:
undetectable		 1wg8B-4tpvA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxz PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS

(Geobacillus
kaustophilus) 		PF01680
(SOR_SNZ) 		3 HIS A 226
ASP A 220
ASN A 156
 None
 0.77A 1wg8B-4wxzA:
undetectable		 1wg8B-4wxzA:
26.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xeb GLUCANASE

(Talaromyces
funiculosus) 		PF00840
(Glyco_hydro_7) 		3 HIS A 132
ASP A 278
ASN A 310
 None
 0.64A 1wg8B-4xebA:
undetectable		 1wg8B-4xebA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zev PFHAD1

(Plasmodium
falciparum) 		PF08282
(Hydrolase_3) 		3 HIS A   0
ASP A   6
ASN A  16
 None
 0.67A 1wg8B-4zevA:
undetectable		 1wg8B-4zevA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp9 PUTATIVE
METHYLTRANSFERASE
PROTEIN

(Bacteroides
fragilis) 		PF13489
(Methyltransf_23) 		3 HIS A  94
ASP A 109
ASN A 130
 SAH  A 303 (-4.3A)
SAH  A 303 (-2.7A)
SAH  A 303 (-3.0A)
 0.61A 1wg8B-5bp9A:
10.9		 1wg8B-5bp9A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bv0 VPS16

(Chaetomium
thermophilum) 		PF04840
(Vps16_C) 		3 HIS B 566
ASP B 605
ASN B 603
 None
 0.85A 1wg8B-5bv0B:
undetectable		 1wg8B-5bv0B:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2i ALR1585 PROTEIN

(Nostoc sp. PCC
7120) 		PF04261
(Dyp_perox) 		3 HIS A 329
ASP A 340
ASN A 316
 None
 0.88A 1wg8B-5c2iA:
undetectable		 1wg8B-5c2iA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2i ALR1585 PROTEIN

(Nostoc sp. PCC
7120) 		PF04261
(Dyp_perox) 		3 HIS A 361
ASP A 236
ASN A  10
 None
 0.82A 1wg8B-5c2iA:
undetectable		 1wg8B-5c2iA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dly PLANTAZOLICIN
METHYLTRANSFERASE
BAML

(Bacillus
velezensis) 		PF13847
(Methyltransf_31) 		3 HIS A 131
ASP A  91
ASN A 113
 SAH  A 301 (-3.8A)
SAH  A 301 (-2.8A)
SAH  A 301 (-3.8A)
 0.83A 1wg8B-5dlyA:
13.7		 1wg8B-5dlyA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ej0 ENVELOPE PROTEIN H3

(Vaccinia virus) 		PF03213
(Pox_P35) 		3 HIS A 144
ASP A 149
ASN A 197
 None
MOH  A 720 (-2.8A)
None
 0.64A 1wg8B-5ej0A:
undetectable		 1wg8B-5ej0A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eu0 BARTONELLA EFFECTOR
PROTEIN (BEP)
SUBSTRATE OF VIRB
T4SS
ANTITOXIN 1

(Bartonella
rochalimae;
Bartonella
rochalimae) 		PF02661
(Fic)
no annotation 		3 HIS B  38
ASP A  53
ASN A  60
 None
 0.75A 1wg8B-5eu0B:
undetectable		 1wg8B-5eu0B:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmh TOLL-LIKE RECEPTOR 7

(Macaca mulatta) 		PF00560
(LRR_1)
PF13306
(LRR_5)
PF13855
(LRR_8) 		3 HIS A 298
ASP A 213
ASN A 215
 None
None
NAG  A 903 ( 1.9A)
 0.87A 1wg8B-5gmhA:
undetectable		 1wg8B-5gmhA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gs2 REPEBODY

(Escherichia
coli) 		PF11921
(DUF3439)
PF12354
(Internalin_N)
PF13855
(LRR_8) 		3 HIS B 209
ASP B 163
ASN B 166
 None
 0.82A 1wg8B-5gs2B:
undetectable		 1wg8B-5gs2B:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hmm EXODEOXYRIBONUCLEASE

(Escherichia
virus T5) 		PF01367
(5_3_exonuc)
PF02739
(5_3_exonuc_N) 		3 HIS A  78
ASP A 261
ASN A 226
 None
 0.82A 1wg8B-5hmmA:
3.8		 1wg8B-5hmmA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i7m DNA PRIMASE LARGE
SUBUNIT

(Homo sapiens) 		PF04104
(DNA_primase_lrg) 		3 HIS A 300
ASP A 380
ASN A 374
 None
 0.87A 1wg8B-5i7mA:
undetectable		 1wg8B-5i7mA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mux 2-METHYLCITRATE
DEHYDRATASE

(Bacillus
subtilis) 		no annotation 3 HIS A 284
ASP A 334
ASN A 329
 None
 0.73A 1wg8B-5muxA:
undetectable		 1wg8B-5muxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nbi DESIGN OF ANTIBODIES
DESIGN OF ANTIBODIES

(Escherichia
coli;
Escherichia
coli) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		3 HIS H  31
ASP H 109
ASN L  38
 None
 0.74A 1wg8B-5nbiH:
undetectable		 1wg8B-5nbiH:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nvr TELOMERE LENGTH
REGULATOR PROTEIN
RIF1

(Saccharomyces
cerevisiae) 		PF12231
(Rif1_N) 		3 HIS A 911
ASP A 938
ASN A 931
 None
 0.71A 1wg8B-5nvrA:
undetectable		 1wg8B-5nvrA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t89 VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF00047
(ig)
PF07679
(I-set)
PF13927
(Ig_3) 		3 HIS X 214
ASP X 130
ASN X 100
 None
None
NAG  X 701 (-1.9A)
 0.79A 1wg8B-5t89X:
undetectable		 1wg8B-5t89X:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT

(Homo sapiens) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		3 HIS A 179
ASP A 482
ASN A 495
 None
 0.87A 1wg8B-5tusA:
undetectable		 1wg8B-5tusA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vi4 INTERLEUKIN-1
RECEPTOR-LIKE 1

(Mus musculus) 		PF13895
(Ig_2) 		3 HIS B 168
ASP B 143
ASN B 146
 None
None
NAG  B 401 (-2.0A)
 0.87A 1wg8B-5vi4B:
undetectable		 1wg8B-5vi4B:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vkq NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L

(Drosophila
melanogaster) 		PF00023
(Ank)
PF00520
(Ion_trans)
PF12796
(Ank_2)
PF13637
(Ank_4) 		3 HIS A 908
ASP A 943
ASN A 989
 None
 0.87A 1wg8B-5vkqA:
undetectable		 1wg8B-5vkqA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4b ADENOSYLHOMOCYSTEINA
SE

(Homo sapiens) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		3 HIS A 162
ASP A 131
ASN A  80
 None
None
9W4  A 502 (-3.3A)
 0.80A 1wg8B-5w4bA:
4.8		 1wg8B-5w4bA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wut ULAM111

(Flavobacterium
sp.) 		no annotation 3 HIS A 161
ASP A 229
ASN A  53
 None
 0.85A 1wg8B-5wutA:
undetectable		 1wg8B-5wutA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x2q TASTE RECEPTOR, TYPE
1, MEMBER 2A

(Oryzias latipes) 		PF01094
(ANF_receptor) 		3 HIS A 105
ASP A  99
ASN A 349
 None
None
NAG  A 904 (-1.9A)
 0.67A 1wg8B-5x2qA:
undetectable		 1wg8B-5x2qA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtg 2,3-DIHYDROXY-2,3-DI
HYDROPHENYLPROPIONAT
E DEHYDROGENASE

(Pseudomonas sp.
MC1) 		PF13561
(adh_short_C2) 		3 HIS B 158
ASP B  90
ASN B  94
 None
 0.81A 1wg8B-5xtgB:
9.3		 1wg8B-5xtgB:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxu RIBOSOMAL PROTEIN
US2

(Toxoplasma
gondii) 		PF00318
(Ribosomal_S2) 		3 HIS A  25
ASP A 150
ASN A  30
 None
 0.82A 1wg8B-5xxuA:
undetectable		 1wg8B-5xxuA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yem CATALASE

(Mycothermus
thermophilus) 		no annotation 3 HIS A 229
ASP A 306
ASN A 456
 HEM  A 704 (-3.8A)
None
None
 0.81A 1wg8B-5yemA:
4.2		 1wg8B-5yemA:
undetectable