SIMILAR PATTERNS OF AMINO ACIDS FOR 1WG8_A_SAMA3142_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c8m HUMAN RHINOVIRUS 16
COAT PROTEIN

(Rhinovirus A) 		PF00073
(Rhv) 		4 HIS 2 130
ASP 2 169
ASN 2 136
ASP 2 175
 None
 1.45A 1wg8A-1c8m2:
undetectable		 1wg8A-1c8m2:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d0n HORSE PLASMA
GELSOLIN

(Equus caballus) 		PF00626
(Gelsolin) 		4 HIS A  86
ASP A 109
ASN A 113
ASP A  84
 None
 1.21A 1wg8A-1d0nA:
0.0		 1wg8A-1d0nA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mdu GELSOLIN PRECURSOR

(Homo sapiens) 		PF00626
(Gelsolin) 		4 HIS A  62
ASP A  85
ASN A  89
ASP A  60
 None
CA  A 403 (-2.5A)
None
None
 1.25A 1wg8A-1mduA:
undetectable		 1wg8A-1mduA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rgi GELSOLIN

(Equus caballus) 		PF00626
(Gelsolin) 		4 HIS G  86
ASP G 109
ASN G 113
ASP G  84
 None
CA  G 404 (-2.8A)
None
None
 1.30A 1wg8A-1rgiG:
0.0		 1wg8A-1rgiG:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t44 CHIMERA OF GELSOLIN
DOMAIN 1 AND
C-TERMINAL DOMAIN OF
THYMOSIN BETA-4

(Homo sapiens;
Mus musculus) 		PF00626
(Gelsolin)
PF01290
(Thymosin) 		4 HIS G  86
ASP G 109
ASN G 113
ASP G  84
 None
CA  G 701 (-2.3A)
None
None
 1.20A 1wg8A-1t44G:
undetectable		 1wg8A-1t44G:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vqv THIAMINE
MONOPHOSPHATE KINASE

(Aquifex
aeolicus) 		PF00586
(AIRS) 		4 HIS A 218
ASP A 207
ASN A  68
ASP A 210
 None
 1.47A 1wg8A-1vqvA:
1.1		 1wg8A-1vqvA:
23.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wg8 PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF01795
(Methyltransf_5) 		4 HIS A  36
ASP A  51
ASN A  74
ASP A  96
 SAM  A3142 (-3.9A)
SAM  A3142 (-2.8A)
SAM  A3142 (-3.0A)
SAM  A3142 (-3.5A)
 0.00A 1wg8A-1wg8A:
49.9		 1wg8A-1wg8A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bpa PROTEIN (SUBUNIT OF
BACTERIOPHAGE
PHIX174)

(Escherichia
virus phiX174) 		PF02305
(Phage_F) 		4 HIS 1 387
ASP 1 104
ASN 1 113
ASP 1 154
 None
 1.20A 1wg8A-2bpa1:
undetectable		 1wg8A-2bpa1:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e8y AMYX PROTEIN

(Bacillus
subtilis) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 HIS A 524
ASP A 465
ASN A 474
ASP A 525
 None
 1.17A 1wg8A-2e8yA:
undetectable		 1wg8A-2e8yA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ff6 GELSOLIN

(Homo sapiens) 		PF00626
(Gelsolin) 		4 HIS G  86
ASP G 109
ASN G 113
ASP G  84
 None
CA  G 701 (-2.4A)
None
None
 1.19A 1wg8A-2ff6G:
undetectable		 1wg8A-2ff6G:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pvs PANCREATIC
LIPASE-RELATED
PROTEIN 2

(Homo sapiens) 		PF00151
(Lipase)
PF01477
(PLAT) 		4 HIS A  75
ASP A  83
ASN A  47
ASP A 105
 None
None
SO4  A 454 (-3.4A)
None
 1.42A 1wg8A-2pvsA:
2.4		 1wg8A-2pvsA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vy0 ENDO-BETA-1,3-GLUCAN
ASE

(Pyrococcus
furiosus) 		PF00722
(Glyco_hydro_16) 		4 HIS A 217
ASP A 287
ASN A  96
ASP A 215
 None
CA  A1298 (-3.3A)
None
None
 1.14A 1wg8A-2vy0A:
undetectable		 1wg8A-2vy0A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wpg AMYLOSUCRASE OR
ALPHA AMYLASE

(Xanthomonas
campestris) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		4 HIS A  35
ASP A  79
ASN A 272
ASP A 312
 None
 1.38A 1wg8A-2wpgA:
undetectable		 1wg8A-2wpgA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b4t RIBONUCLEASE PH

(Mycobacterium
tuberculosis) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		4 HIS A  35
ASP A 176
ASN A 190
ASP A 123
 None
None
PO4  A 260 ( 4.6A)
None
 1.48A 1wg8A-3b4tA:
undetectable		 1wg8A-3b4tA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cze SUCROSE HYDROLASE

(Xanthomonas
citri) 		PF00128
(Alpha-amylase) 		4 HIS A  34
ASP A  78
ASN A 271
ASP A 311
 None
 1.38A 1wg8A-3czeA:
undetectable		 1wg8A-3czeA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ian CHITINASE

(Lactococcus
lactis) 		PF00704
(Glyco_hydro_18) 		4 HIS A 358
ASP A 222
ASN A 225
ASP A 155
 NA  A   1 ( 4.8A)
EDO  A 366 (-3.1A)
None
NA  A   1 ( 2.9A)
 1.36A 1wg8A-3ianA:
0.7		 1wg8A-3ianA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iqd OCTOPINE
DEHYDROGENASE

(Pecten maximus) 		PF02317
(Octopine_DH) 		4 HIS B 295
ASP B 244
ASN B 251
ASP B 292
 None
 1.31A 1wg8A-3iqdB:
3.8		 1wg8A-3iqdB:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mga ENTEROCHELIN
ESTERASE

(Salmonella
enterica) 		PF00756
(Esterase)
PF11806
(DUF3327) 		4 HIS A 244
ASP A 206
ASN A 213
ASP A 241
 None
 1.25A 1wg8A-3mgaA:
1.0		 1wg8A-3mgaA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr2 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Coxiella
burnetii) 		PF00215
(OMPdecase) 		4 HIS A  33
ASP A 208
ASN A 175
ASP A   5
 None
 1.43A 1wg8A-3tr2A:
undetectable		 1wg8A-3tr2A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tu5 GELSOLIN,PROTEIN
CORDON-BLEU,THYMOSIN
BETA-4

(Homo sapiens;
Mus musculus) 		PF00626
(Gelsolin) 		4 HIS B  62
ASP B  85
ASN B  89
ASP B  60
 None
 1.19A 1wg8A-3tu5B:
undetectable		 1wg8A-3tu5B:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tw5 TRANSGLUTAMINASE
ELICITOR

(Phytophthora
sojae) 		PF16683
(TGase_elicitor) 		4 HIS A 491
ASP A 169
ASN A 167
ASP A 361
 None
 1.38A 1wg8A-3tw5A:
undetectable		 1wg8A-3tw5A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3g DNA-BINDING PROTEIN
SMUBP-2

(Homo sapiens) 		PF13086
(AAA_11)
PF13087
(AAA_12) 		4 HIS A 213
ASP A 375
ASN A 352
ASP A 400
 None
 1.46A 1wg8A-4b3gA:
0.0		 1wg8A-4b3gA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dfs GLYCOSIDE HYDROLASE,
FAMILY 16

(Thermotoga
petrophila) 		PF00722
(Glyco_hydro_16) 		4 HIS A 179
ASP A 249
ASN A  60
ASP A 177
 None
CA  A 301 (-3.1A)
None
None
 0.91A 1wg8A-4dfsA:
undetectable		 1wg8A-4dfsA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lvo SUBTILISIN-LIKE
SERINE PROTEASE

(Plasmodium
falciparum) 		PF00082
(Peptidase_S8) 		4 HIS A 428
ASP A 425
ASN A 421
ASP A 372
 None
 1.46A 1wg8A-4lvoA:
2.3		 1wg8A-4lvoA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lvo SUBTILISIN-LIKE
SERINE PROTEASE

(Plasmodium
falciparum) 		PF00082
(Peptidase_S8) 		4 HIS A 428
ASP A 462
ASN A 417
ASP A 372
 None
 1.39A 1wg8A-4lvoA:
2.3		 1wg8A-4lvoA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4me4 METAL DEPENDENT
PHOSPHOHYDROLASE

(Persephonella
marina) 		PF01590
(GAF)
PF01966
(HD) 		4 HIS A 276
ASP A 308
ASN A 188
ASP A 222
 FE  A 401 (-3.4A)
None
None
FE  A 402 ( 2.5A)
 1.35A 1wg8A-4me4A:
undetectable		 1wg8A-4me4A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pkh GELSOLIN,TROPOMODULI
N-1 CHIMERA

(Homo sapiens) 		PF00626
(Gelsolin)
PF03250
(Tropomodulin) 		4 HIS B 113
ASP B 136
ASN B 140
ASP B 111
 None
 1.18A 1wg8A-4pkhB:
undetectable		 1wg8A-4pkhB:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pki GELSOLIN,TROPOMODULI
N-1 CHIMERA

(Homo sapiens) 		PF00626
(Gelsolin) 		4 HIS G 113
ASP G 136
ASN G 140
ASP G 111
 None
 1.23A 1wg8A-4pkiG:
undetectable		 1wg8A-4pkiG:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tr2 SUBTILISIN-LIKE 1
SERINE PROTEASE

(Plasmodium
vivax) 		PF00082
(Peptidase_S8) 		4 HIS A 372
ASP A 406
ASN A 361
ASP A 316
 None
 1.39A 1wg8A-4tr2A:
2.3		 1wg8A-4tr2A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA

(Homo sapiens) 		PF00626
(Gelsolin) 		4 HIS G  62
ASP G  85
ASN G  89
ASP G  60
 None
 1.27A 1wg8A-4z94G:
undetectable		 1wg8A-4z94G:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fgn LIPOOLIGOSACCHARIDE
PHOSPHOETHANOLAMINE
TRANSFERASE A

(Neisseria
meningitidis) 		PF00884
(Sulfatase)
PF08019
(DUF1705) 		4 HIS A 378
ASP A 338
ASN A 343
ASP A 324
 None
 1.11A 1wg8A-5fgnA:
1.4		 1wg8A-5fgnA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o3w PEPTIDE CYCLASE 1

(Gypsophila
vaccaria) 		no annotation 4 HIS A 238
ASP A 297
ASN A 315
ASP A 257
 None
 1.34A 1wg8A-5o3wA:
0.8		 1wg8A-5o3wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj PROTEIN CFT1

(Saccharomyces
cerevisiae) 		no annotation 4 HIS A 792
ASP A  45
ASN A 412
ASP A 877
 None
 1.50A 1wg8A-6eojA:
undetectable		 1wg8A-6eojA:
12.09