SIMILAR PATTERNS OF AMINO ACIDS FOR 1W9E_A_BEZA1274

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1oby SYNTENIN 1

(Homo sapiens) 		PF00595
(PDZ) 		4 HIS A 202
SER A 226
ARG A 229
ASN A 230
 SO4  A1272 (-3.9A)
SO4  A1272 (-2.7A)
SO4  A1272 (-3.9A)
SO4  A1272 (-3.1A)
 0.46A 1w9eA-1obyA:
13.5		 1w9eA-1obyA:
48.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a2p SYNTENIN-1

(Rattus
norvegicus) 		PF00595
(PDZ) 		4 HIS A 204
SER A 228
ARG A 231
ASN A 232
 None
 0.59A 1w9eA-5a2pA:
25.6		 1w9eA-5a2pA:
92.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08771
(FRB_dom)
PF11865
(DUF3385) 		4 HIS A 759
SER A 762
ARG A 766
ASN A 763
 None
 1.36A 1w9eA-5h64A:
0.0		 1w9eA-5h64A:
5.14