SIMILAR PATTERNS OF AMINO ACIDS FOR 1W5U_B_DVAB8

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf2 ISOAMYLASE

(Pseudomonas
amyloderamosa) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		3 VAL A  22
VAL A  59
TRP A  57
 None
 0.83A 1w5uA-1bf2A:
undetectable
1w5uB-1bf2A:
undetectable		 1w5uA-1bf2A:
2.38
1w5uB-1bf2A:
2.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ehk BA3-TYPE
CYTOCHROME-C OXIDASE

(Thermus
thermophilus) 		PF00115
(COX1) 		3 VAL A 163
VAL A 158
TRP A 190
 None
 0.95A 1w5uA-1ehkA:
undetectable
1w5uB-1ehkA:
undetectable		 1w5uA-1ehkA:
3.54
1w5uB-1ehkA:
3.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g38 MODIFICATION
METHYLASE TAQI

(Thermus
aquaticus) 		PF07669
(Eco57I)
PF12950
(TaqI_C) 		3 VAL A 164
VAL A 205
TRP A 168
 None
 0.76A 1w5uA-1g38A:
undetectable
1w5uB-1g38A:
undetectable		 1w5uA-1g38A:
5.10
1w5uB-1g38A:
5.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq1 CYTOCHROME CD1
NITRITE REDUCTASE

(Paracoccus
pantotrophus) 		PF02239
(Cytochrom_D1)
PF13442
(Cytochrome_CBB3) 		3 VAL A 377
VAL A 367
TRP A 429
 None
 0.85A 1w5uA-1gq1A:
undetectable
1w5uB-1gq1A:
undetectable		 1w5uA-1gq1A:
2.64
1w5uB-1gq1A:
2.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hix ENDO-1,4-BETA-XYLANA
SE

(Streptomyces
sp. S38) 		PF00457
(Glyco_hydro_11) 		3 VAL A 116
VAL A 139
TRP A 158
 None
 0.86A 1w5uA-1hixA:
undetectable
1w5uB-1hixA:
undetectable		 1w5uA-1hixA:
8.86
1w5uB-1hixA:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iah TRANSIENT RECEPTOR
POTENTIAL-RELATED
PROTEIN

(Mus musculus) 		PF02816
(Alpha_kinase) 		3 VAL A1652
VAL A1665
TRP A1656
 None
 0.92A 1w5uA-1iahA:
undetectable
1w5uB-1iahA:
undetectable		 1w5uA-1iahA:
6.88
1w5uB-1iahA:
6.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1id2 AMICYANIN

(Paracoccus
versutus) 		PF00127
(Copper-bind) 		3 VAL A  24
VAL A  22
TRP A  46
 None
 0.78A 1w5uA-1id2A:
undetectable
1w5uB-1id2A:
undetectable		 1w5uA-1id2A:
8.89
1w5uB-1id2A:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lwh 4-ALPHA-GLUCANOTRANS
FERASE

(Thermotoga
maritima) 		PF00128
(Alpha-amylase)
PF09178
(DUF1945) 		3 VAL A  19
VAL A   8
TRP A 348
 CA  A 914 (-4.2A)
None
None
 0.83A 1w5uA-1lwhA:
undetectable
1w5uB-1lwhA:
undetectable		 1w5uA-1lwhA:
7.03
1w5uB-1lwhA:
7.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogy PERIPLASMIC NITRATE
REDUCTASE

(Rhodobacter
sphaeroides) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		3 VAL A 763
VAL A 797
TRP A 689
 None
 0.84A 1w5uA-1ogyA:
undetectable
1w5uB-1ogyA:
undetectable		 1w5uA-1ogyA:
5.19
1w5uB-1ogyA:
5.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9s REPLICASE
POLYPROTEIN 1AB

(Human
coronavirus
229E) 		PF05409
(Peptidase_C30) 		3 VAL A  36
VAL A  17
TRP A  31
 None
 0.92A 1w5uA-1p9sA:
undetectable
1w5uB-1p9sA:
undetectable		 1w5uA-1p9sA:
7.64
1w5uB-1p9sA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1usc PUTATIVE STYRENE
MONOOXYGENASE SMALL
COMPONENT

(Thermus
thermophilus) 		PF01613
(Flavin_Reduct) 		3 VAL A  38
VAL A  52
TRP A  39
 FMN  A1179 (-4.0A)
None
ACT  A1180 ( 3.3A)
 0.96A 1w5uA-1uscA:
undetectable
1w5uB-1uscA:
undetectable		 1w5uA-1uscA:
8.39
1w5uB-1uscA:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v0f ENDO-ALPHA-SIALIDASE

(Enterobacteria
phage K1F) 		PF12217
(End_beta_propel)
PF12218
(End_N_terminal)
PF12219
(End_tail_spike) 		3 VAL A 704
VAL A 702
TRP A 328
 VAL  A 704 ( 0.6A)
VAL  A 702 ( 0.5A)
TRP  A 328 ( 0.5A)
 0.95A 1w5uA-1v0fA:
undetectable
1w5uB-1v0fA:
undetectable		 1w5uA-1v0fA:
3.41
1w5uB-1v0fA:
3.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhn PUTATIVE FLAVIN
OXIDOREDUCTASE

(Thermotoga
maritima) 		PF01207
(Dus) 		3 VAL A 188
VAL A 212
TRP A 174
 None
 0.88A 1w5uA-1vhnA:
undetectable
1w5uB-1vhnA:
undetectable		 1w5uA-1vhnA:
3.00
1w5uB-1vhnA:
3.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wg4 HYPOTHETICAL PROTEIN
(RIKEN CDNA
6030486K23)

(Mus musculus) 		PF00076
(RRM_1) 		3 VAL A  47
VAL A  55
TRP A  29
 None
 0.80A 1w5uA-1wg4A:
undetectable
1w5uB-1wg4A:
undetectable		 1w5uA-1wg4A:
9.88
1w5uB-1wg4A:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x4c SPLICING FACTOR,
ARGININE/SERINE-RICH
1

(Mus musculus) 		PF00076
(RRM_1) 		3 VAL A  47
VAL A  55
TRP A  29
 None
 0.84A 1w5uA-1x4cA:
undetectable
1w5uB-1x4cA:
undetectable		 1w5uA-1x4cA:
20.59
1w5uB-1x4cA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x5c PROTEIN
DISULFIDE-ISOMERASE

(Homo sapiens) 		PF00085
(Thioredoxin) 		3 VAL A   9
VAL A  61
TRP A  47
 None
 0.93A 1w5uA-1x5cA:
undetectable
1w5uB-1x5cA:
undetectable		 1w5uA-1x5cA:
10.96
1w5uB-1x5cA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr5 GENOME POLYPROTEIN

(Rhinovirus B) 		PF00680
(RdRP_1) 		3 VAL A 387
VAL A 216
TRP A 218
 None
 0.98A 1w5uA-1xr5A:
undetectable
1w5uB-1xr5A:
undetectable		 1w5uA-1xr5A:
2.83
1w5uB-1xr5A:
2.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zry FATTY ACID-BINDING
PROTEIN, LIVER

(Gallus gallus) 		PF14651
(Lipocalin_7) 		3 VAL A  38
VAL A   8
TRP A   6
 None
 0.91A 1w5uA-1zryA:
undetectable
1w5uB-1zryA:
undetectable		 1w5uA-1zryA:
8.33
1w5uB-1zryA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zub REGULATING SYNAPTIC
MEMBRANE EXOCYTOSIS
PROTEIN 1

(Rattus
norvegicus) 		PF00595
(PDZ) 		3 VAL A 699
VAL A 614
TRP A 673
 None
 0.99A 1w5uA-1zubA:
undetectable
1w5uB-1zubA:
undetectable		 1w5uA-1zubA:
8.41
1w5uB-1zubA:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azw MUTT/NUDIX FAMILY
PROTEIN

(Enterococcus
faecalis) 		PF00293
(NUDIX) 		3 VAL A 102
VAL A  25
TRP A 143
 None
 0.93A 1w5uA-2azwA:
undetectable
1w5uB-2azwA:
undetectable		 1w5uA-2azwA:
7.26
1w5uB-2azwA:
7.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cda GLUCOSE
DEHYDROGENASE

(Sulfolobus
solfataricus) 		PF08240
(ADH_N)
PF16912
(Glu_dehyd_C) 		3 VAL A 169
VAL A 165
TRP A 172
 None
 0.97A 1w5uA-2cdaA:
undetectable
1w5uB-2cdaA:
undetectable		 1w5uA-2cdaA:
5.26
1w5uB-2cdaA:
5.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csp RIM BINDING PROTEIN
2

(Homo sapiens) 		no annotation 3 VAL A  24
VAL A  26
TRP A  39
 None
 0.86A 1w5uA-2cspA:
undetectable
1w5uB-2cspA:
undetectable		 1w5uA-2cspA:
8.04
1w5uB-2cspA:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2edf OBSCURIN

(Homo sapiens) 		PF07679
(I-set) 		3 VAL A  56
VAL A  66
TRP A  41
 None
 0.94A 1w5uA-2edfA:
undetectable
1w5uB-2edfA:
undetectable		 1w5uA-2edfA:
8.60
1w5uB-2edfA:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eo1 CDNA FLJ14124 FIS,
CLONE MAMMA1002498

(Homo sapiens) 		PF07679
(I-set) 		3 VAL A  59
VAL A  69
TRP A  44
 None
 0.88A 1w5uA-2eo1A:
undetectable
1w5uB-2eo1A:
undetectable		 1w5uA-2eo1A:
11.36
1w5uB-2eo1A:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8r HEPATOCYTE NUCLEAR
FACTOR 1-BETA

(Homo sapiens) 		PF00046
(Homeobox)
PF04814
(HNF-1_N) 		3 VAL A 142
VAL A 140
TRP A 171
 None
 0.82A 1w5uA-2h8rA:
undetectable
1w5uB-2h8rA:
undetectable		 1w5uA-2h8rA:
5.69
1w5uB-2h8rA:
5.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2htv NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 VAL A 317
VAL A 384
TRP A 302
 None
 0.92A 1w5uA-2htvA:
undetectable
1w5uB-2htvA:
undetectable		 1w5uA-2htvA:
3.43
1w5uB-2htvA:
3.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2if6 HYPOTHETICAL PROTEIN
YIIX

(Escherichia
coli) 		PF05708
(Peptidase_C92) 		3 VAL A 193
VAL A  87
TRP A  19
 None
 0.74A 1w5uA-2if6A:
undetectable
1w5uB-2if6A:
undetectable		 1w5uA-2if6A:
8.27
1w5uB-2if6A:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7c BETA-GLUCOSIDASE A

(Thermotoga
maritima) 		PF00232
(Glyco_hydro_1) 		3 VAL A 170
VAL A 194
TRP A 134
 None
 0.91A 1w5uA-2j7cA:
undetectable
1w5uB-2j7cA:
undetectable		 1w5uA-2j7cA:
2.35
1w5uB-2j7cA:
2.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jw4 CYTOPLASMIC PROTEIN
NCK1

(Homo sapiens) 		PF00018
(SH3_1) 		3 VAL A   9
VAL A  11
TRP A  33
 None
 0.88A 1w5uA-2jw4A:
undetectable
1w5uB-2jw4A:
undetectable		 1w5uA-2jw4A:
21.43
1w5uB-2jw4A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jw4 CYTOPLASMIC PROTEIN
NCK1

(Homo sapiens) 		PF00018
(SH3_1) 		3 VAL A   9
VAL A  44
TRP A  33
 None
 0.80A 1w5uA-2jw4A:
undetectable
1w5uB-2jw4A:
undetectable		 1w5uA-2jw4A:
21.43
1w5uB-2jw4A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m7s SERINE/ARGININE-RICH
SPLICING FACTOR 1

(Homo sapiens) 		PF00076
(RRM_1) 		3 VAL A  47
VAL A  55
TRP A  29
 None
 0.85A 1w5uA-2m7sA:
undetectable
1w5uB-2m7sA:
undetectable		 1w5uA-2m7sA:
8.89
1w5uB-2m7sA:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2miz M04 IMMUNOEVASIN

(Murid
betaherpesvirus
1) 		PF12216
(m04gp34like) 		3 VAL A  71
VAL A  64
TRP A  62
 None
 0.89A 1w5uA-2mizA:
undetectable
1w5uB-2mizA:
undetectable		 1w5uA-2mizA:
6.94
1w5uB-2mizA:
6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o4u DIMERIC DIHYDRODIOL
DEHYDROGENASE

(Macaca
fascicularis) 		PF01408
(GFO_IDH_MocA) 		3 VAL X1031
VAL X1067
TRP X1005
 None
 0.93A 1w5uA-2o4uX:
undetectable
1w5uB-2o4uX:
undetectable		 1w5uA-2o4uX:
3.08
1w5uB-2o4uX:
3.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		3 VAL A 217
VAL A 264
TRP A 213
 None
 0.88A 1w5uA-2phkA:
undetectable
1w5uB-2phkA:
undetectable		 1w5uA-2phkA:
4.42
1w5uB-2phkA:
4.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pi5 DNA-DIRECTED RNA
POLYMERASE

(Escherichia
virus T7) 		PF00940
(RNA_pol)
PF14700
(RPOL_N) 		3 VAL A 735
VAL A 725
TRP A 422
 None
 0.78A 1w5uA-2pi5A:
undetectable
1w5uB-2pi5A:
undetectable		 1w5uA-2pi5A:
2.26
1w5uB-2pi5A:
2.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pke HALOACID
DELAHOGENASE-LIKE
FAMILY HYDROLASE

(Xanthomonas
campestris) 		PF13419
(HAD_2) 		3 VAL A 182
VAL A 192
TRP A 201
 None
 0.96A 1w5uA-2pkeA:
undetectable
1w5uB-2pkeA:
undetectable		 1w5uA-2pkeA:
5.32
1w5uB-2pkeA:
5.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wxu PHOSPHOLIPASE C

(Clostridium
perfringens) 		PF00882
(Zn_dep_PLPC)
PF01477
(PLAT) 		3 VAL A 243
VAL A  34
TRP A 109
 None
 0.75A 1w5uA-2wxuA:
undetectable
1w5uB-2wxuA:
undetectable		 1w5uA-2wxuA:
2.59
1w5uB-2wxuA:
2.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x66 PRNB

(Pseudomonas
fluorescens) 		PF08933
(DUF1864) 		3 VAL A 119
VAL A 117
TRP A 120
 None
 0.49A 1w5uA-2x66A:
undetectable
1w5uB-2x66A:
undetectable		 1w5uA-2x66A:
5.63
1w5uB-2x66A:
5.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7q POSSIBLE THIAMINE
BIOSYNTHESIS ENZYME

(Candida
albicans) 		PF09084
(NMT1) 		3 VAL A  82
VAL A 192
TRP A 190
 None
 0.82A 1w5uA-2x7qA:
undetectable
1w5uB-2x7qA:
undetectable		 1w5uA-2x7qA:
4.97
1w5uB-2x7qA:
4.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x9o 15,16-DIHYDROBILIVER
DIN-FERREDOXIN
OXIDOREDUCTASE

(Synechococcus
sp. WH 8020) 		PF05996
(Fe_bilin_red) 		3 VAL A  54
VAL A  83
TRP A  52
 None
 0.84A 1w5uA-2x9oA:
undetectable
1w5uB-2x9oA:
undetectable		 1w5uA-2x9oA:
8.33
1w5uB-2x9oA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xk9 CHECKPOINT KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		3 VAL A 415
VAL A 463
TRP A 411
 None
 0.86A 1w5uA-2xk9A:
undetectable
1w5uB-2xk9A:
undetectable		 1w5uA-2xk9A:
4.68
1w5uB-2xk9A:
4.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3a PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT BETA ISOFORM

(Mus musculus) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B) 		3 VAL A 435
VAL A 473
TRP A 456
 None
 0.95A 1w5uA-2y3aA:
undetectable
1w5uB-2y3aA:
undetectable		 1w5uA-2y3aA:
1.45
1w5uB-2y3aA:
1.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yuz MYOSIN-BINDING
PROTEIN C, SLOW-TYPE

(Homo sapiens) 		PF07679
(I-set) 		3 VAL A  54
VAL A  64
TRP A  39
 None
 0.94A 1w5uA-2yuzA:
undetectable
1w5uB-2yuzA:
undetectable		 1w5uA-2yuzA:
8.54
1w5uB-2yuzA:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8e GALACTO-N-BIOSE/LACT
O-N-BIOSE I
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Bifidobacterium
longum) 		PF01547
(SBP_bac_1) 		3 VAL A  75
VAL A  42
TRP A  66
 None
 0.58A 1w5uA-2z8eA:
undetectable
1w5uB-2z8eA:
undetectable		 1w5uA-2z8eA:
2.70
1w5uB-2z8eA:
2.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbl PUTATIVE ISOMERASE

(Salmonella
enterica) 		PF07221
(GlcNAc_2-epim) 		3 VAL A 314
VAL A 299
TRP A 316
 None
None
BMA  A 501 (-3.8A)
 0.85A 1w5uA-2zblA:
undetectable
1w5uB-2zblA:
undetectable		 1w5uA-2zblA:
4.55
1w5uB-2zblA:
4.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqu AT4G19810

(Arabidopsis
thaliana) 		PF00704
(Glyco_hydro_18) 		3 VAL A 229
VAL A   3
TRP A 178
 None
 0.84A 1w5uA-3aquA:
undetectable
1w5uB-3aquA:
undetectable		 1w5uA-3aquA:
4.41
1w5uB-3aquA:
4.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3azq AMINOPEPTIDASE

(Streptomyces
morookaense) 		PF00326
(Peptidase_S9) 		3 VAL A 317
VAL A 309
TRP A 338
 None
 0.84A 1w5uA-3azqA:
undetectable
1w5uB-3azqA:
undetectable		 1w5uA-3azqA:
2.05
1w5uB-3azqA:
2.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3beg SPLICING FACTOR,
ARGININE/SERINE-RICH
1

(Homo sapiens) 		PF00076
(RRM_1) 		3 VAL B 152
VAL B 160
TRP B 134
 None
 0.91A 1w5uA-3begB:
undetectable
1w5uB-3begB:
undetectable		 1w5uA-3begB:
22.86
1w5uB-3begB:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo sapiens) 		PF00069
(Pkinase) 		3 VAL A 207
VAL A 253
TRP A 203
 None
 0.79A 1w5uA-3c0iA:
undetectable
1w5uB-3c0iA:
undetectable		 1w5uA-3c0iA:
4.76
1w5uB-3c0iA:
4.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5m OLIGOGALACTURONATE
LYASE

(Vibrio
parahaemolyticus) 		PF14583
(Pectate_lyase22) 		3 VAL A  98
VAL A 116
TRP A 130
 None
 0.84A 1w5uA-3c5mA:
undetectable
1w5uB-3c5mA:
undetectable		 1w5uA-3c5mA:
4.98
1w5uB-3c5mA:
4.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c75 AMICYANIN

(Paracoccus
versutus) 		PF00127
(Copper-bind) 		3 VAL A  24
VAL A  22
TRP A  46
 None
 0.90A 1w5uA-3c75A:
undetectable
1w5uB-3c75A:
undetectable		 1w5uA-3c75A:
8.89
1w5uB-3c75A:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3da8 PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN

(Mycobacterium
tuberculosis) 		PF00551
(Formyl_trans_N) 		3 VAL A  66
VAL A  46
TRP A  77
 None
 0.94A 1w5uA-3da8A:
undetectable
1w5uB-3da8A:
undetectable		 1w5uA-3da8A:
5.12
1w5uB-3da8A:
5.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dls PAS
DOMAIN-CONTAINING
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		3 VAL A1191
VAL A1228
TRP A1187
 None
 0.76A 1w5uA-3dlsA:
undetectable
1w5uB-3dlsA:
undetectable		 1w5uA-3dlsA:
4.83
1w5uB-3dlsA:
4.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		3 VAL A 210
VAL A 257
TRP A 206
 None
 0.77A 1w5uA-3dxnA:
undetectable
1w5uB-3dxnA:
undetectable		 1w5uA-3dxnA:
5.49
1w5uB-3dxnA:
5.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e77 PHOSPHOSERINE
AMINOTRANSFERASE

(Homo sapiens) 		PF00266
(Aminotran_5) 		3 VAL A 124
VAL A 103
TRP A 140
 None
 0.92A 1w5uA-3e77A:
undetectable
1w5uB-3e77A:
undetectable		 1w5uA-3e77A:
6.25
1w5uB-3e77A:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fed GLUTAMATE
CARBOXYPEPTIDASE III

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		3 VAL A 101
VAL A 348
TRP A 424
 None
 0.91A 1w5uA-3fedA:
undetectable
1w5uB-3fedA:
undetectable		 1w5uA-3fedA:
1.78
1w5uB-3fedA:
1.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3foa TAIL SHEATH PROTEIN
GP18

(Escherichia
virus T4) 		PF04984
(Phage_sheath_1)
PF17481
(Phage_sheath_1N) 		3 VAL A 389
VAL A 394
TRP A 359
 None
 0.83A 1w5uA-3foaA:
undetectable
1w5uB-3foaA:
undetectable		 1w5uA-3foaA:
3.70
1w5uB-3foaA:
3.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fz0 NUCLEOSIDE
HYDROLASE, PUTATIVE

(Trypanosoma
brucei) 		PF01156
(IU_nuc_hydro) 		3 VAL A  37
VAL A  41
TRP A  38
 None
 0.72A 1w5uA-3fz0A:
undetectable
1w5uB-3fz0A:
undetectable		 1w5uA-3fz0A:
7.69
1w5uB-3fz0A:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gkq TERMINAL OXYGENASE
COMPONENT OF
CARBAZOLE
1,9A-DIOXYGENASE

(Sphingomonas
sp. KA1) 		PF00355
(Rieske)
PF11723
(Aromatic_hydrox) 		3 VAL A  61
VAL A  65
TRP A 102
 None
 0.99A 1w5uA-3gkqA:
undetectable
1w5uB-3gkqA:
undetectable		 1w5uA-3gkqA:
7.61
1w5uB-3gkqA:
7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbc CHOLOYLGLYCINE
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF02275
(CBAH) 		3 VAL A 291
VAL A 284
TRP A 304
 None
None
EDO  A   7 (-3.9A)
 0.73A 1w5uA-3hbcA:
undetectable
1w5uB-3hbcA:
undetectable		 1w5uA-3hbcA:
4.37
1w5uB-3hbcA:
4.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3

(Toxoplasma
gondii) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		3 VAL A 263
VAL A 310
TRP A 259
 None
 0.77A 1w5uA-3hztA:
undetectable
1w5uB-3hztA:
undetectable		 1w5uA-3hztA:
3.29
1w5uB-3hztA:
3.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6u SERINE/THREONINE-PRO
TEIN KINASE CHK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00498
(FHA) 		3 VAL A 415
VAL A 463
TRP A 411
 None
 0.93A 1w5uA-3i6uA:
undetectable
1w5uB-3i6uA:
undetectable		 1w5uA-3i6uA:
3.30
1w5uB-3i6uA:
3.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2n TAIL SHEATH PROTEIN
GP18

(Escherichia
virus T4) 		PF04984
(Phage_sheath_1)
PF17481
(Phage_sheath_1N)
PF17482
(Phage_sheath_1C) 		3 VAL U 389
VAL U 394
TRP U 359
 None
 0.83A 1w5uA-3j2nU:
undetectable
1w5uB-3j2nU:
undetectable		 1w5uA-3j2nU:
2.37
1w5uB-3j2nU:
2.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP3

(Saccharomyces
cerevisiae) 		PF06544
(DUF1115)
PF08572
(PRP3) 		3 VAL K 341
VAL K 383
TRP K 428
 None
 0.89A 1w5uA-3jcmK:
undetectable
1w5uB-3jcmK:
undetectable		 1w5uA-3jcmK:
2.73
1w5uB-3jcmK:
2.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl9 GLUTAMYL
AMINOPEPTIDASE

(Streptococcus
pneumoniae) 		PF05343
(Peptidase_M42) 		3 VAL A 312
VAL A 235
TRP A 180
 None
 0.87A 1w5uA-3kl9A:
undetectable
1w5uB-3kl9A:
undetectable		 1w5uA-3kl9A:
3.49
1w5uB-3kl9A:
3.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l12 PUTATIVE
GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Ruegeria
pomeroyi) 		PF03009
(GDPD) 		3 VAL A  19
VAL A  17
TRP A 311
 None
 0.96A 1w5uA-3l12A:
undetectable
1w5uB-3l12A:
undetectable		 1w5uA-3l12A:
5.05
1w5uB-3l12A:
5.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2o BIOSYNTHETIC
ARGININE
DECARBOXYLASE

(Vibrio
vulnificus) 		PF02784
(Orn_Arg_deC_N) 		3 VAL A 521
VAL A 490
TRP A  23
 None
 0.97A 1w5uA-3n2oA:
undetectable
1w5uB-3n2oA:
undetectable		 1w5uA-3n2oA:
3.11
1w5uB-3n2oA:
3.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o9t NONSTRUCTURAL
PROTEIN 1

(Influenza A
virus) 		PF00600
(Flu_NS1) 		3 VAL A 194
VAL A 192
TRP A 203
 None
 0.98A 1w5uA-3o9tA:
undetectable
1w5uB-3o9tA:
undetectable		 1w5uA-3o9tA:
8.26
1w5uB-3o9tA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3os6 ISOCHORISMATE
SYNTHASE DHBC

(Bacillus
anthracis) 		PF00425
(Chorismate_bind) 		3 VAL A 200
VAL A 345
TRP A 343
 None
 0.94A 1w5uA-3os6A:
undetectable
1w5uB-3os6A:
undetectable		 1w5uA-3os6A:
5.13
1w5uB-3os6A:
5.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q6t 43.2 KDA SALIVARY
PROTEIN

(Lutzomyia
longipalpis) 		PF03022
(MRJP) 		3 VAL A  93
VAL A 103
TRP A 101
 None
 0.95A 1w5uA-3q6tA:
undetectable
1w5uB-3q6tA:
undetectable		 1w5uA-3q6tA:
3.40
1w5uB-3q6tA:
3.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uem PROTEIN
DISULFIDE-ISOMERASE

(Homo sapiens) 		PF00085
(Thioredoxin)
PF13848
(Thioredoxin_6) 		3 VAL A 369
VAL A 421
TRP A 407
 None
 0.94A 1w5uA-3uemA:
undetectable
1w5uB-3uemA:
undetectable		 1w5uA-3uemA:
3.50
1w5uB-3uemA:
3.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfo POLY A POLYMERASE

(Aquifex
aeolicus) 		PF01743
(PolyA_pol)
PF01966
(HD)
PF12627
(PolyA_pol_RNAbd) 		3 VAL A  59
VAL A  40
TRP A  43
 None
 0.94A 1w5uA-3wfoA:
undetectable
1w5uB-3wfoA:
undetectable		 1w5uA-3wfoA:
4.26
1w5uB-3wfoA:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfp POLY A POLYMERASE

(synthetic
construct;
Aquifex
aeolicus) 		PF01743
(PolyA_pol)
PF01966
(HD)
PF12627
(PolyA_pol_RNAbd) 		3 VAL A  59
VAL A  40
TRP A  43
 None
 0.92A 1w5uA-3wfpA:
undetectable
1w5uB-3wfpA:
undetectable		 1w5uA-3wfpA:
2.75
1w5uB-3wfpA:
2.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvs PUTATIVE
MONOOXYGENASE

(Streptomyces
sp. SN-593) 		PF00067
(p450) 		3 VAL A 314
VAL A  41
TRP A  50
 None
 0.99A 1w5uA-3wvsA:
undetectable
1w5uB-3wvsA:
undetectable		 1w5uA-3wvsA:
6.22
1w5uB-3wvsA:
6.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bqb NEOGENIN

(Mus musculus) 		PF00041
(fn3) 		3 VAL A 992
VAL A 994
TRP A1008
 None
 0.93A 1w5uA-4bqbA:
undetectable
1w5uB-4bqbA:
undetectable		 1w5uA-4bqbA:
6.51
1w5uB-4bqbA:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4el1 PROTEIN
DISULFIDE-ISOMERASE

(Homo sapiens) 		PF00085
(Thioredoxin)
PF13848
(Thioredoxin_6) 		3 VAL A 369
VAL A 421
TRP A 407
 None
 0.82A 1w5uA-4el1A:
undetectable
1w5uB-4el1A:
undetectable		 1w5uA-4el1A:
3.37
1w5uB-4el1A:
3.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7z RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Mus musculus) 		PF00027
(cNMP_binding)
PF00610
(DEP)
PF00617
(RasGEF)
PF00618
(RasGEF_N) 		3 VAL A 974
VAL A 810
TRP A 808
 None
 0.98A 1w5uA-4f7zA:
undetectable
1w5uB-4f7zA:
undetectable		 1w5uA-4f7zA:
2.20
1w5uB-4f7zA:
2.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgu LEGUMAIN

(Homo sapiens) 		PF01650
(Peptidase_C13) 		3 VAL A 141
VAL A  32
TRP A  30
 None
 0.74A 1w5uA-4fguA:
undetectable
1w5uB-4fguA:
undetectable		 1w5uA-4fguA:
2.88
1w5uB-4fguA:
2.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jqo ORNITHINE
CARBAMOYLTRANSFERASE

(Vibrio
vulnificus) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 VAL A 327
VAL A 329
TRP A 127
 None
 0.88A 1w5uA-4jqoA:
undetectable
1w5uB-4jqoA:
undetectable		 1w5uA-4jqoA:
2.87
1w5uB-4jqoA:
2.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmv GLUTATHIONE
TRANSFERASE

(Phanerochaete
chrysosporium) 		PF13417
(GST_N_3) 		3 VAL A 220
VAL A 215
TRP A 221
 None
 0.87A 1w5uA-4lmvA:
undetectable
1w5uB-4lmvA:
undetectable		 1w5uA-4lmvA:
9.17
1w5uB-4lmvA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lzi MULTICYSTATIN

(Solanum
tuberosum) 		PF00031
(Cystatin) 		3 VAL A  51
VAL A  77
TRP A 174
 None
 0.98A 1w5uA-4lziA:
undetectable
1w5uB-4lziA:
undetectable		 1w5uA-4lziA:
4.69
1w5uB-4lziA:
4.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qma CYSTEINE DIOXYGENASE
TYPE I

(Cupriavidus
pinatubonensis) 		PF05995
(CDO_I) 		3 VAL A  98
VAL A 139
TRP A  99
 None
None
EDO  A 308 (-3.9A)
 0.72A 1w5uA-4qmaA:
undetectable
1w5uB-4qmaA:
undetectable		 1w5uA-4qmaA:
9.20
1w5uB-4qmaA:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rs1 GRANULOCYTE-MACROPHA
GE
COLONY-STIMULATING
FACTOR RECEPTOR
SUBUNIT ALPHA

(Homo sapiens) 		PF09240
(IL6Ra-bind) 		3 VAL B 205
VAL B 207
TRP B 218
 None
 0.98A 1w5uA-4rs1B:
undetectable
1w5uB-4rs1B:
undetectable		 1w5uA-4rs1B:
2.56
1w5uB-4rs1B:
2.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w4t MXAA

(Stigmatella
aurantiaca) 		PF07993
(NAD_binding_4) 		3 VAL A1367
VAL A1363
TRP A1433
 None
 0.98A 1w5uA-4w4tA:
undetectable
1w5uB-4w4tA:
undetectable		 1w5uA-4w4tA:
3.21
1w5uB-4w4tA:
3.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmv AMINOPEPTIDASE N

(Escherichia
coli) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		3 VAL A  64
VAL A  62
TRP A  74
 None
 0.96A 1w5uA-4xmvA:
undetectable
1w5uB-4xmvA:
undetectable		 1w5uA-4xmvA:
1.84
1w5uB-4xmvA:
1.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zb3 NUDIX HYDROLASE 7

(Arabidopsis
thaliana) 		PF00293
(NUDIX) 		3 VAL A 133
VAL A 121
TRP A 221
 None
 0.95A 1w5uA-4zb3A:
undetectable
1w5uB-4zb3A:
undetectable		 1w5uA-4zb3A:
12.04
1w5uB-4zb3A:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgk ACTIVE HELICASE

(Staphylococcus
aureus) 		PF06048
(DUF927) 		3 VAL A 348
VAL A 224
TRP A 163
 None
 0.97A 1w5uA-5dgkA:
undetectable
1w5uB-5dgkA:
undetectable		 1w5uA-5dgkA:
5.02
1w5uB-5dgkA:
5.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5en2 GD01 HEAVY CHAIN
PRE-GLYCOPROTEIN
POLYPROTEIN GP
COMPLEX

(Mus musculus;
Argentinian
mammarenavirus) 		PF07654
(C1-set)
PF07686
(V-set)
no annotation 		3 VAL A  97
VAL C 117
TRP A  33
 None
 0.97A 1w5uA-5en2A:
undetectable
1w5uB-5en2A:
undetectable		 1w5uA-5en2A:
6.03
1w5uB-5en2A:
6.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gwo PROBABLE PROTEIN
PHOSPHATASE 2C 50

(Oryza sativa) 		PF00481
(PP2C) 		3 VAL A 291
VAL A 215
TRP A 160
 None
 1.00A 1w5uA-5gwoA:
undetectable
1w5uB-5gwoA:
undetectable		 1w5uA-5gwoA:
4.29
1w5uB-5gwoA:
4.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE

(Thermotoga
neapolitana) 		PF00232
(Glyco_hydro_1) 		3 VAL A 168
VAL A 192
TRP A 132
 None
 0.94A 1w5uA-5idiA:
undetectable
1w5uB-5idiA:
undetectable		 1w5uA-5idiA:
3.05
1w5uB-5idiA:
3.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idk GENOME
POLYPROTEIN,SERINE
PROTEASE SUBUNIT
NS2B, SERINE
PROTEASE NS3

(West Nile virus) 		PF00949
(Peptidase_S7)
PF01002
(Flavi_NS2B) 		3 VAL A1003
VAL A1072
TRP A1005
 None
 0.74A 1w5uA-5idkA:
undetectable
1w5uB-5idkA:
undetectable		 1w5uA-5idkA:
10.89
1w5uB-5idkA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k59 UNCHARACTERIZED
LEUKOCIDIN-LIKE
PROTEIN 2

(Staphylococcus
aureus) 		no annotation 3 VAL D 117
VAL D 189
TRP D 187
 None
 0.94A 1w5uA-5k59D:
undetectable
1w5uB-5k59D:
undetectable		 1w5uA-5k59D:
4.52
1w5uB-5k59D:
4.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lhe N-(5'-PHOSPHORIBOSYL
)ANTHRANILATE
ISOMERASE

(Thermococcus
kodakarensis) 		PF00697
(PRAI) 		3 VAL A 176
VAL A 148
TRP A 175
 None
 0.98A 1w5uA-5lheA:
undetectable
1w5uB-5lheA:
undetectable		 1w5uA-5lheA:
6.86
1w5uB-5lheA:
6.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL

(Homo sapiens) 		PF00069
(Pkinase) 		3 VAL A 766
VAL A 812
TRP A 762
 None
 0.81A 1w5uA-5lohA:
undetectable
1w5uB-5lohA:
undetectable		 1w5uA-5lohA:
5.49
1w5uB-5lohA:
5.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nh0 REPLICASE
POLYPROTEIN 1AB

(Human
coronavirus
NL63) 		no annotation 3 VAL A  36
VAL A  17
TRP A  31
 None
 0.96A 1w5uA-5nh0A:
undetectable
1w5uB-5nh0A:
undetectable		 1w5uA-5nh0A:
undetectable
1w5uB-5nh0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		3 VAL A1785
VAL A1816
TRP A1758
 None
 0.98A 1w5uA-5nugA:
undetectable
1w5uB-5nugA:
undetectable		 1w5uA-5nugA:
0.74
1w5uB-5nugA:
0.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oyj VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		no annotation 3 VAL C 499
VAL C 518
TRP C 458
 None
 0.97A 1w5uA-5oyjC:
undetectable
1w5uB-5oyjC:
undetectable		 1w5uA-5oyjC:
undetectable
1w5uB-5oyjC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wox UNCHARACTERIZED
PROTEIN

(Mycolicibacterium
smegmatis) 		no annotation 3 VAL A  79
VAL A  94
TRP A  92
 None
 0.64A 1w5uA-5woxA:
undetectable
1w5uB-5woxA:
undetectable		 1w5uA-5woxA:
undetectable
1w5uB-5woxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x3j GLYCOSIDE HYDROLASE
FAMILY 31

(Kribbella
flavida) 		no annotation 3 VAL A  35
VAL A  90
TRP A  88
 None
 0.76A 1w5uA-5x3jA:
undetectable
1w5uB-5x3jA:
undetectable		 1w5uA-5x3jA:
undetectable
1w5uB-5x3jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eks SIALIDASE

(Vibrio cholerae) 		no annotation 3 VAL A  94
VAL A  82
TRP A 103
 None
 0.95A 1w5uA-6eksA:
undetectable
1w5uB-6eksA:
undetectable		 1w5uA-6eksA:
1.96
1w5uB-6eksA:
1.96