SIMILAR PATTERNS OF AMINO ACIDS FOR 1W0G_A_MYTA1499_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ad3 ALDEHYDE
DEHYDROGENASE (CLASS
3)

(Rattus
norvegicus) 		PF00171
(Aldedh) 		4 SER A 367
ILE A 373
THR A 380
ALA A 350
 None
 0.94A 1w0gA-1ad3A:
0.0		 1w0gA-1ad3A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1al3 CYS REGULON
TRANSCRIPTIONAL
ACTIVATOR CYSB

(Klebsiella
aerogenes) 		PF03466
(LysR_substrate) 		4 ILE A 134
ALA A 148
THR A 270
ALA A 107
 None
SO4  A 500 ( 3.9A)
SO4  A 500 ( 4.9A)
None
 0.92A 1w0gA-1al3A:
undetectable		 1w0gA-1al3A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3l SUBTILISIN-CARLSBERG

(Bacillus
licheniformis) 		PF00082
(Peptidase_S8) 		4 SER A 191
ILE A 165
ALA A 176
ALA A 223
 None
None
CA  A 284 ( 4.3A)
None
 0.77A 1w0gA-1c3lA:
undetectable		 1w0gA-1c3lA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ewk METABOTROPIC
GLUTAMATE RECEPTOR
SUBTYPE 1

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		4 SER A 207
ILE A 190
ALA A 243
ALA A 214
 None
 0.98A 1w0gA-1ewkA:
0.0		 1w0gA-1ewkA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h54 MALTOSE
PHOSPHORYLASE

(Lactobacillus
brevis) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		4 ARG A 384
ILE A 342
ALA A 364
ALA A 435
 None
 0.85A 1w0gA-1h54A:
0.0		 1w0gA-1h54A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ikp EXOTOXIN A

(Pseudomonas
aeruginosa) 		PF09009
(Exotox-A_cataly)
PF09101
(Exotox-A_bind)
PF09102
(Exotox-A_target) 		4 ARG A 458
ILE A 312
ALA A 336
ALA A 264
 None
 0.96A 1w0gA-1ikpA:
0.0		 1w0gA-1ikpA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ize ASPARTIC PROTEINASE

(Aspergillus
oryzae) 		PF00026
(Asp) 		4 SER A 128
ILE A 129
ALA A 125
ALA A 312
 None
 0.87A 1w0gA-1izeA:
0.0		 1w0gA-1izeA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j32 ASPARTATE
AMINOTRANSFERASE

(Phormidium
lapideum) 		PF00155
(Aminotran_1_2) 		4 SER A 233
ILE A 204
ALA A 236
ALA A 278
 None
PLP  A 413 ( 3.9A)
PLP  A 413 (-3.4A)
None
 0.64A 1w0gA-1j32A:
0.0		 1w0gA-1j32A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j9l STATIONARY PHASE
SURVIVAL PROTEIN

(Thermotoga
maritima) 		PF01975
(SurE) 		4 ILE A  16
ALA A  33
THR A  67
ALA A  78
 None
 0.86A 1w0gA-1j9lA:
0.0		 1w0gA-1j9lA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jpu GLYCEROL
DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF00465
(Fe-ADH) 		4 ILE A 325
ALA A 329
THR A 333
ALA A 254
 None
 0.68A 1w0gA-1jpuA:
undetectable		 1w0gA-1jpuA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7k DEOXYRIBOSE-PHOSPHAT
E ALDOLASE

(Aeropyrum
pernix) 		PF01791
(DeoC) 		4 ILE A 219
ALA A 198
THR A 168
ALA A 186
 None
 0.86A 1w0gA-1n7kA:
undetectable		 1w0gA-1n7kA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o66 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE

(Neisseria
meningitidis) 		PF02548
(Pantoate_transf) 		4 SER A 194
ALA A 173
THR A 122
ALA A 167
 None
 1.00A 1w0gA-1o66A:
undetectable		 1w0gA-1o66A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oh9 ACETYLGLUTAMATE
KINASE

(Escherichia
coli) 		PF00696
(AA_kinase) 		4 ARG A 255
ILE A 177
ALA A 235
ALA A 194
 None
 0.85A 1w0gA-1oh9A:
undetectable		 1w0gA-1oh9A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pjq SIROHEME SYNTHASE

(Salmonella
enterica) 		PF00590
(TP_methylase)
PF10414
(CysG_dimeriser)
PF13241
(NAD_binding_7)
PF14824
(Sirohm_synth_M) 		4 SER A 252
ILE A 255
ALA A 223
ALA A 332
 None
None
None
ACT  A 505 (-3.0A)
 0.93A 1w0gA-1pjqA:
undetectable		 1w0gA-1pjqA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Wolinella
succinogenes) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 SER A 390
ILE A 375
ALA A 240
ALA A 181
 None
None
None
FAD  A1656 (-3.8A)
 0.96A 1w0gA-1qlbA:
0.0		 1w0gA-1qlbA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1su7 CARBON MONOXIDE
DEHYDROGENASE 2

(Carboxydothermus
hydrogenoformans) 		PF03063
(Prismane) 		4 ILE A 293
ALA A 318
THR A 321
ALA A  12
 None
 0.90A 1w0gA-1su7A:
undetectable		 1w0gA-1su7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tzn ANTHRAX TOXIN
RECEPTOR 2

(Homo sapiens) 		PF03495
(Binary_toxB)
PF17475
(Binary_toxB_2)
PF17476
(Binary_toxB_3) 		4 SER a1081
ILE a1083
ALA a1127
ALA a1134
 None
 0.96A 1w0gA-1tzna:
undetectable		 1w0gA-1tzna:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vj0 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING

(Thermotoga
maritima) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ILE A 259
ALA A 256
THR A 251
ALA A 246
 None
 0.74A 1w0gA-1vj0A:
undetectable		 1w0gA-1vj0A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjo ALANINE--GLYOXYLATE
AMINOTRANSFERASE

(Nostoc sp. PCC
7120) 		PF00266
(Aminotran_5) 		4 SER A 187
ILE A 193
THR A 221
ALA A  85
 None
 0.98A 1w0gA-1vjoA:
undetectable		 1w0gA-1vjoA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkm CONSERVED
HYPOTHETICAL PROTEIN
TM1464

(Thermotoga
maritima) 		PF04227
(Indigoidine_A) 		4 SER A 104
ILE A  51
ALA A  49
ALA A 279
 None
 0.80A 1w0gA-1vkmA:
undetectable		 1w0gA-1vkmA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa5 IMPORTIN ALPHA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00514
(Arm)
PF01749
(IBB)
PF16186
(Arm_3) 		4 SER B 226
ILE B 232
ALA B 235
ALA B 193
 None
 0.98A 1w0gA-1wa5B:
undetectable		 1w0gA-1wa5B:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wr8 PHOSPHOGLYCOLATE
PHOSPHATASE

(Pyrococcus
horikoshii) 		PF08282
(Hydrolase_3) 		4 SER A   7
ILE A 158
ALA A 184
ALA A 205
 None
 0.96A 1w0gA-1wr8A:
undetectable		 1w0gA-1wr8A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2akz GAMMA ENOLASE

(Homo sapiens) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 SER A 114
ALA A 352
THR A 322
ALA A  45
 None
 0.92A 1w0gA-2akzA:
undetectable		 1w0gA-2akzA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ebd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Aquifex
aeolicus) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 ILE A 107
ALA A 109
THR A 301
ALA A 295
 None
 0.99A 1w0gA-2ebdA:
undetectable		 1w0gA-2ebdA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g02 NISIN BIOSYNTHESIS
PROTEIN NISC

(Lactococcus
lactis) 		PF05147
(LANC_like) 		4 SER A 234
ILE A 169
ALA A 224
ALA A 300
 None
 0.85A 1w0gA-2g02A:
undetectable		 1w0gA-2g02A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iml HYPOTHETICAL PROTEIN

(Archaeoglobus
fulgidus) 		PF04289
(DUF447) 		4 ILE A  15
ALA A  17
THR A  19
ALA A 105
 None
 0.90A 1w0gA-2imlA:
undetectable		 1w0gA-2imlA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlx XYLULOSE KINASE

(Escherichia
coli) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 ARG A 403
SER A 399
ILE A 314
ALA A 407
 None
 0.97A 1w0gA-2nlxA:
undetectable		 1w0gA-2nlxA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5p FERRIPYOVERDINE
RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07660
(STN)
PF07715
(Plug) 		4 SER A 705
ILE A 696
ALA A 668
ALA A 644
 None
 0.99A 1w0gA-2o5pA:
undetectable		 1w0gA-2o5pA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po4 VIRION RNA
POLYMERASE

(Escherichia
virus N4) 		no annotation 4 ILE A 291
ALA A 294
THR A  72
ALA A  77
 None
 0.94A 1w0gA-2po4A:
undetectable		 1w0gA-2po4A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ptz ENOLASE

(Trypanosoma
brucei) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 SER A 113
ILE A 350
ALA A 353
THR A 323
ALA A  46
 None
 1.08A 1w0gA-2ptzA:
undetectable		 1w0gA-2ptzA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qnd FMR1 PROTEIN

(Homo sapiens) 		PF00013
(KH_1) 		4 SER A 128
ILE A 129
ALA A  67
ALA A  18
 None
 0.93A 1w0gA-2qndA:
undetectable		 1w0gA-2qndA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8q SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00171
(Aldedh) 		4 ARG A 125
ILE A 132
ALA A 161
THR A 212
 None
 0.98A 1w0gA-2w8qA:
undetectable		 1w0gA-2w8qA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3acz METHIONINE
GAMMA-LYASE

(Entamoeba
histolytica) 		PF01053
(Cys_Met_Meta_PP) 		4 SER A  90
ILE A 229
ALA A 220
ALA A 196
 None
 0.95A 1w0gA-3aczA:
undetectable		 1w0gA-3aczA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bg2 DGTP
TRIPHOSPHOHYDROLASE

(Leeuwenhoekiella
blandensis) 		PF01966
(HD) 		4 SER A 215
ILE A 417
ALA A 421
THR A 425
 None
 0.78A 1w0gA-3bg2A:
undetectable		 1w0gA-3bg2A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxh CENTRAL GLYCOLYTIC
GENE REGULATOR

(Bacillus
subtilis) 		PF04198
(Sugar-bind) 		4 ILE A 314
ALA A 305
THR A 152
ALA A 131
 None
None
F6P  A 401 (-3.5A)
None
 0.83A 1w0gA-3bxhA:
undetectable		 1w0gA-3bxhA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0b CONSERVED ARCHAEAL
PROTEIN Q6M145

(Methanococcus
maripaludis) 		PF01968
(Hydantoinase_A) 		4 SER A 238
ILE A 243
ALA A 248
ALA A 196
 None
 0.96A 1w0gA-3c0bA:
undetectable		 1w0gA-3c0bA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3col PUTATIVE
TRANSCRIPTION
REGULATOR

(Lactobacillus
plantarum) 		PF00440
(TetR_N) 		4 ARG A  65
ILE A 107
THR A 164
ALA A  99
 None
 0.87A 1w0gA-3colA:
undetectable		 1w0gA-3colA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwu DNA-3-METHYLADENINE
GLYCOSYLASE 2

(Escherichia
coli) 		PF00730
(HhH-GPD)
PF06029
(AlkA_N) 		4 SER A  26
ILE A 153
ALA A 139
ALA A 132
 None
 0.97A 1w0gA-3cwuA:
undetectable		 1w0gA-3cwuA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d19 CONSERVED
METALLOPROTEIN

(Bacillus cereus) 		PF11155
(DUF2935) 		4 SER A 246
ILE A 239
ALA A 235
ALA A 184
 None
 0.94A 1w0gA-3d19A:
0.4		 1w0gA-3d19A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ec9 UNCHARACTERIZED
NTF2-LIKE PROTEIN

(Burkholderia
thailandensis) 		PF12680
(SnoaL_2) 		4 ARG A 115
ILE A  40
ALA A  37
ALA A 118
 None
 0.99A 1w0gA-3ec9A:
undetectable		 1w0gA-3ec9A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ff1 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Staphylococcus
aureus) 		PF00342
(PGI) 		4 ILE A 170
ALA A 172
THR A 174
ALA A 180
 None
 0.99A 1w0gA-3ff1A:
undetectable		 1w0gA-3ff1A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g4e REGUCALCIN

(Homo sapiens) 		PF08450
(SGL) 		4 SER A 170
ILE A 202
ALA A 125
ALA A 119
 None
 0.79A 1w0gA-3g4eA:
undetectable		 1w0gA-3g4eA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3goa 3-KETOACYL-COA
THIOLASE

(Salmonella
enterica) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 SER A  37
ILE A  10
ALA A 247
ALA A  72
 None
 0.97A 1w0gA-3goaA:
undetectable		 1w0gA-3goaA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gw7 UNCHARACTERIZED
PROTEIN YEDJ

(Escherichia
coli) 		PF01966
(HD) 		4 SER A 108
ALA A  77
THR A  81
ALA A  54
 None
 0.95A 1w0gA-3gw7A:
undetectable		 1w0gA-3gw7A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hd6 AMMONIUM TRANSPORTER
RH TYPE C

(Homo sapiens) 		PF00909
(Ammonium_transp) 		4 ARG A 210
SER A 207
THR A   5
ALA A 433
 None
 0.92A 1w0gA-3hd6A:
0.0		 1w0gA-3hd6A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdx SUSD SUPERFAMILY
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 ARG A 470
ILE A 450
ALA A 405
ALA A 250
 None
 0.88A 1w0gA-3hdxA:
undetectable		 1w0gA-3hdxA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hs0 COBRA VENOM FACTOR

(Naja kaouthia) 		PF00207
(A2M) 		4 SER B 725
ILE B 723
ALA B 876
ALA B 812
 None
 0.99A 1w0gA-3hs0B:
undetectable		 1w0gA-3hs0B:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3im8 MALONYL ACYL CARRIER
PROTEIN TRANSACYLASE

(Streptococcus
pneumoniae) 		PF00698
(Acyl_transf_1) 		4 SER A  37
ILE A  33
ALA A  67
ALA A 113
 None
 0.92A 1w0gA-3im8A:
undetectable		 1w0gA-3im8A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3klj NAD(FAD)-DEPENDENT
DEHYDROGENASE,
NIRB-FAMILY
(N-TERMINAL DOMAIN)

(Clostridium
acetobutylicum) 		PF07992
(Pyr_redox_2) 		4 SER A 304
ILE A 197
ALA A 156
ALA A  50
 None
 0.98A 1w0gA-3kljA:
undetectable		 1w0gA-3kljA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mcx SUSD SUPERFAMILY
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 ARG A 446
ILE A 426
ALA A 384
ALA A 241
 None
 0.82A 1w0gA-3mcxA:
undetectable		 1w0gA-3mcxA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3otr ENOLASE

(Toxoplasma
gondii) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 SER A 120
ALA A 365
THR A 335
ALA A  47
 None
 0.97A 1w0gA-3otrA:
undetectable		 1w0gA-3otrA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ow8 WD REPEAT-CONTAINING
PROTEIN 61

(Homo sapiens) 		PF00400
(WD40) 		4 SER A 153
ILE A 193
ALA A 208
ALA A 239
 None
 0.92A 1w0gA-3ow8A:
undetectable		 1w0gA-3ow8A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qn3 ENOLASE

(Campylobacter
jejuni) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 SER A 114
ILE A 339
THR A 312
ALA A  48
 None
 0.97A 1w0gA-3qn3A:
undetectable		 1w0gA-3qn3A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rao PUTATIVE
LUCIFERASE-LIKE
MONOOXYGENASE

(Bacillus cereus) 		PF00296
(Bac_luciferase) 		5 ARG A 108
SER A 105
ILE A 101
ALA A  68
ALA A  33
 None
 1.41A 1w0gA-3raoA:
undetectable		 1w0gA-3raoA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rc0 N-LYSINE
METHYLTRANSFERASE
SETD6

(Homo sapiens) 		PF00856
(SET)
PF09273
(Rubis-subs-bind) 		4 ARG A 139
SER A 104
ILE A 105
ALA A 128
 None
 0.96A 1w0gA-3rc0A:
undetectable		 1w0gA-3rc0A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE

(Bacillus
anthracis) 		PF00908
(dTDP_sugar_isom) 		4 ILE A 102
ALA A  80
THR A 128
ALA A  55
 None
 0.87A 1w0gA-3rykA:
undetectable		 1w0gA-3rykA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s8i PROTEIN DDI1 HOMOLOG
1

(Homo sapiens) 		PF09668
(Asp_protease) 		4 SER A 319
ILE A 298
ALA A 290
ALA A 263
 None
 0.95A 1w0gA-3s8iA:
undetectable		 1w0gA-3s8iA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3snx PUTATIVE SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 SER A 127
ILE A 128
ALA A  46
ALA A  53
 None
 0.98A 1w0gA-3snxA:
undetectable		 1w0gA-3snxA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3szb ALDEHYDE
DEHYDROGENASE

(Homo sapiens) 		PF00171
(Aldedh) 		4 SER A 367
ILE A 373
THR A 380
ALA A 350
 None
 0.89A 1w0gA-3szbA:
undetectable		 1w0gA-3szbA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufx SUCCINYL-COA
SYNTHETASE BETA
SUBUNIT

(Thermus
aquaticus) 		PF00549
(Ligase_CoA)
PF08442
(ATP-grasp_2) 		4 ILE B 280
ALA B 284
THR B 314
ALA B 341
 None
 0.96A 1w0gA-3ufxB:
undetectable		 1w0gA-3ufxB:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aip FE-REGULATED PROTEIN
B

(Neisseria
meningitidis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 ILE A 523
ALA A 578
THR A 529
ALA A 581
 None
 0.98A 1w0gA-4aipA:
undetectable		 1w0gA-4aipA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b18 IMPORTIN SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00514
(Arm)
PF16186
(Arm_3) 		4 ARG A 397
ALA A 443
THR A 405
ALA A 400
 None
 0.97A 1w0gA-4b18A:
undetectable		 1w0gA-4b18A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b4o EPIMERASE FAMILY
PROTEIN SDR39U1

(Homo sapiens) 		PF01370
(Epimerase)
PF08338
(DUF1731) 		4 ILE A 195
ALA A 199
THR A 203
ALA A  22
 None
 0.85A 1w0gA-4b4oA:
undetectable		 1w0gA-4b4oA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c23 L-FUCULOSE KINASE
FUCK

(Streptococcus
pneumoniae) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 ILE A 205
ALA A 174
THR A 176
ALA A 235
 None
 0.92A 1w0gA-4c23A:
0.0		 1w0gA-4c23A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
ALPHA

(Methanothermobacter
marburgensis) 		PF00374
(NiFeSe_Hases) 		4 SER A 129
ILE A 133
ALA A 107
ALA A 114
 None
 0.79A 1w0gA-4ci0A:
0.1		 1w0gA-4ci0A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dry 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Sinorhizobium
meliloti) 		PF00106
(adh_short) 		4 ARG A  57
ILE A 223
ALA A 227
ALA A  32
 None
 0.99A 1w0gA-4dryA:
undetectable		 1w0gA-4dryA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola) 		PF13354
(Beta-lactamase2) 		4 ARG A 284
SER A 224
ILE A 221
THR A 265
 None
 0.96A 1w0gA-4ev4A:
undetectable		 1w0gA-4ev4A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g2u ANCYLOSTOMA-SECRETED
PROTEIN-LIKE PROTEIN

(Ostertagia
ostertagi) 		PF00188
(CAP) 		4 SER A 135
ILE A 131
ALA A 124
ALA A  51
 None
 0.90A 1w0gA-4g2uA:
undetectable		 1w0gA-4g2uA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g7f ENOLASE

(Trypanosoma
cruzi) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 SER A 113
ILE A 350
ALA A 353
THR A 323
ALA A  46
 None
 1.16A 1w0gA-4g7fA:
undetectable		 1w0gA-4g7fA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gn8 REGUCALCIN

(Mus musculus) 		PF08450
(SGL) 		4 SER A 170
ILE A 202
ALA A 125
ALA A 119
 None
None
ASO  A 305 (-4.6A)
None
 0.80A 1w0gA-4gn8A:
undetectable		 1w0gA-4gn8A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ix1 HYPOTHETICAL PROTEIN

(Rhodococcus
opacus) 		no annotation 4 SER A 233
ILE A 229
ALA A 122
ALA A 113
 None
 0.99A 1w0gA-4ix1A:
undetectable		 1w0gA-4ix1A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k0e HEAVY METAL CATION
TRICOMPONENT EFFLUX
PUMP ZNEA(CZCA-LIKE)

(Cupriavidus
metallidurans) 		PF00873
(ACR_tran) 		4 ILE A 929
ALA A 928
THR A1004
ALA A 894
 None
 0.95A 1w0gA-4k0eA:
0.7		 1w0gA-4k0eA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ksi LEUCINE
AMINOPEPTIDASE 1,
CHLOROPLASTIC

(Solanum
lycopersicum) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		4 SER A 416
ILE A 439
ALA A 435
ALA A 309
 None
 0.92A 1w0gA-4ksiA:
undetectable		 1w0gA-4ksiA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lp2 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CYSB

(Salmonella
enterica) 		PF03466
(LysR_substrate) 		4 ILE B 134
ALA B 148
THR B 270
ALA B 107
 None
 0.95A 1w0gA-4lp2B:
undetectable		 1w0gA-4lp2B:
21.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ny4 CYTOCHROME P450 3A4

(Homo sapiens) 		PF00067
(p450) 		6 ARG A 105
SER A 119
ILE A 301
ALA A 305
THR A 309
ALA A 370
 HEM  A 601 ( 2.8A)
2QH  A 602 (-3.9A)
None
2QH  A 602 ( 3.6A)
2QH  A 602 ( 3.7A)
2QH  A 602 ( 3.1A)
 0.41A 1w0gA-4ny4A:
56.9		 1w0gA-4ny4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qax 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Staphylococcus
aureus) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		4 ARG A 324
ILE A  69
ALA A 482
ALA A 315
 None
 0.96A 1w0gA-4qaxA:
undetectable		 1w0gA-4qaxA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rpc PUTATIVE ALPHA/BETA
HYDROLASE

(Desulfitobacterium
hafniense) 		PF12697
(Abhydrolase_6) 		4 SER A 203
ILE A 256
ALA A  88
ALA A 103
 None
 0.84A 1w0gA-4rpcA:
undetectable		 1w0gA-4rpcA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s12 N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE

(Yersinia
enterocolitica) 		PF01380
(SIS) 		4 ILE A  99
ALA A  70
THR A 144
ALA A 140
 None
SO4  A 301 ( 4.8A)
SO4  A 301 (-3.0A)
SO4  A 301 (-3.4A)
 0.91A 1w0gA-4s12A:
undetectable		 1w0gA-4s12A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uad IMPORTIN SUBUNIT
ALPHA-7

(Homo sapiens) 		PF00514
(Arm)
PF16186
(Arm_3) 		4 ARG A 395
ALA A 441
THR A 403
ALA A 398
 None
 0.96A 1w0gA-4uadA:
undetectable		 1w0gA-4uadA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ur2 TETRACHLOROETHENE
REDUCTIVE
DEHALOGENASE
CATALYTIC SUBUNIT
PCEA

(Sulfurospirillum
multivorans) 		PF13484
(Fer4_16)
PF13486
(Dehalogenase) 		4 ARG A  89
SER A 236
ILE A 432
ALA A  79
 None
None
IOD  A1467 ( 4.7A)
None
 0.90A 1w0gA-4ur2A:
undetectable		 1w0gA-4ur2A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wep PUTATIVE
OSMOPROTECTANT
UPTAKE SYSTEM
SUBSTRATE-BINDING
PROTEIN OSMF

(Escherichia
coli) 		PF04069
(OpuAC) 		4 ILE A 169
ALA A 164
THR A 202
ALA A 215
 None
 0.88A 1w0gA-4wepA:
undetectable		 1w0gA-4wepA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wyr ACETYL-COA
ACETYLTRANSFERASE

(Clostridium
acetobutylicum) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 SER A 182
ILE A 344
ALA A 320
ALA A 327
 None
 0.89A 1w0gA-4wyrA:
undetectable		 1w0gA-4wyrA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bnc HEME BINDING PROTEIN
MSMEG_6519

(Mycolicibacterium
smegmatis) 		PF10615
(DUF2470)
PF13883
(Pyrid_oxidase_2) 		4 SER A  40
ILE A  37
ALA A 106
ALA A  98
 None
 0.91A 1w0gA-5bncA:
undetectable		 1w0gA-5bncA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bq9 UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		PF12252
(SidE) 		4 SER A 466
ILE A 133
ALA A 303
ALA A 308
 None
 0.92A 1w0gA-5bq9A:
1.8		 1w0gA-5bq9A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c9l PLL LECTIN

(Photorhabdus
luminescens) 		PF03984
(DUF346) 		4 SER A 240
ILE A  17
ALA A  23
ALA A 283
 None
 0.94A 1w0gA-5c9lA:
undetectable		 1w0gA-5c9lA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ccx TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRMT61A

(Homo sapiens) 		PF08704
(GCD14) 		4 SER A 110
ILE A 182
ALA A 188
ALA A 195
 SAH  A 301 (-3.1A)
SAH  A 301 ( 3.8A)
None
None
 0.87A 1w0gA-5ccxA:
undetectable		 1w0gA-5ccxA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dm6 50S RIBOSOMAL
PROTEIN L18

(Deinococcus
radiodurans) 		PF00861
(Ribosomal_L18p) 		4 SER L  56
ILE L  38
ALA L  40
ALA L  78
 None
 0.84A 1w0gA-5dm6L:
undetectable		 1w0gA-5dm6L:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ed8 MKIAA0668 PROTEIN

(Mus musculus) 		PF07738
(Sad1_UNC) 		4 SER A 616
ILE A 621
ALA A 624
ALA A 585
 None
 0.95A 1w0gA-5ed8A:
undetectable		 1w0gA-5ed8A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5erb POLYKETIDE SYNTHASE

(Bacillus
amyloliquefaciens) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 ARG A  17
ILE A 356
ALA A 366
ALA A 252
 None
 0.97A 1w0gA-5erbA:
undetectable		 1w0gA-5erbA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f5n MONOOXYGENASE

(Micromonospora
sp. TP-A0468) 		PF05368
(NmrA) 		4 SER A  77
ALA A 101
THR A 104
ALA A  68
 None
 0.81A 1w0gA-5f5nA:
undetectable		 1w0gA-5f5nA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gju ATP-DEPENDENT RNA
HELICASE DEAD

(Escherichia
coli) 		PF00270
(DEAD) 		4 SER A  54
ILE A  32
ALA A  59
ALA A  93
 AMP  A 301 (-4.1A)
None
None
None
 0.98A 1w0gA-5gjuA:
undetectable		 1w0gA-5gjuA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		4 ILE B 281
ALA B 285
THR B 289
ALA B 334
 None
 0.85A 1w0gA-5hb4B:
undetectable		 1w0gA-5hb4B:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		4 ILE B 281
ALA B 285
THR B 289
ALA B 432
 None
 0.97A 1w0gA-5hb4B:
undetectable		 1w0gA-5hb4B:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy4 RING-OPENING
AMIDOHYDROLASE

(Frankia sp.
Eul1b) 		PF09663
(Amido_AtzD_TrzD) 		4 ARG A 229
ILE A 237
ALA A 215
ALA A 153
 None
 0.94A 1w0gA-5hy4A:
undetectable		 1w0gA-5hy4A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3e PUTATIVE
DEOXYRIBONUCLEASE-2

(Burkholderia
thailandensis) 		PF03265
(DNase_II) 		4 SER A  68
ILE A   3
ALA A 106
ALA A 125
 None
 0.95A 1w0gA-5i3eA:
undetectable		 1w0gA-5i3eA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opt 40S RIBOSOMAL
PROTEIN S16,
PUTATIVE
40S RIBOSOMAL
PROTEIN S5, PUTATIVE

(Trypanosoma
cruzi) 		no annotation 4 ARG r  64
ILE r  91
ALA r  57
ALA O   3
 None
 0.79A 1w0gA-5optr:
undetectable		 1w0gA-5optr:
16.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5veu CYTOCHROME P450 3A5

(Homo sapiens) 		no annotation 6 ARG A 105
SER A 119
ILE A 301
ALA A 305
THR A 309
ALA A 370
 HEM  A 601 (-2.8A)
RIT  A 602 (-3.7A)
RIT  A 602 ( 4.9A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 3.5A)
RIT  A 602 (-3.3A)
 0.69A 1w0gA-5veuA:
50.7		 1w0gA-5veuA:
83.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vhs 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 3

(Homo sapiens) 		PF01399
(PCI)
PF08375
(Rpn3_C) 		4 SER V 415
ILE V 447
ALA V 441
ALA V 434
 None
 0.79A 1w0gA-5vhsV:
undetectable		 1w0gA-5vhsV:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vkq NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L

(Drosophila
melanogaster) 		PF00023
(Ank)
PF00520
(Ion_trans)
PF12796
(Ank_2)
PF13637
(Ank_4) 		4 ILE A 843
ALA A 831
THR A 829
ALA A 864
 None
 0.97A 1w0gA-5vkqA:
undetectable		 1w0gA-5vkqA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6x MRNA CAPPING ENZYME
P5

(Rice dwarf
virus) 		no annotation 4 SER C 207
ILE C 229
ALA C 472
ALA C 506
 None
 0.67A 1w0gA-5x6xC:
undetectable		 1w0gA-5x6xC:
9.07