SIMILAR PATTERNS OF AMINO ACIDS FOR 1VQ1_A_SAMA301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aec ACTINIDIN

(Actinidia
chinensis) 		PF00112
(Peptidase_C1) 		5 ILE A 208
GLY A 157
ALA A 159
ILE A 160
THR A 205
 None
 1.44A 1vq1A-1aecA:
undetectable		 1vq1A-1aecA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1elj MALTODEXTRIN-BINDING
PROTEIN

(Pyrococcus
furiosus) 		PF13416
(SBP_bac_8) 		5 THR A 117
ILE A 166
GLU A 199
PHE A 195
PRO A 248
 None
 1.25A 1vq1A-1eljA:
undetectable		 1vq1A-1eljA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1irx LYSYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF01921
(tRNA-synt_1f) 		5 PHE A  39
ILE A 273
GLY A  37
ILE A 315
VAL A 287
 None
 1.13A 1vq1A-1irxA:
undetectable		 1vq1A-1irxA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jfi TRANSCRIPTION
REGULATOR NC2 ALPHA
CHAIN
TRANSCRIPTION
REGULATOR NC2 BETA
CHAIN

(Homo sapiens;
Homo sapiens) 		PF00808
(CBFD_NFYB_HMF)
PF00808
(CBFD_NFYB_HMF) 		5 ILE A  20
ALA A  41
ILE A  38
THR B 144
VAL B 140
 None
 1.22A 1vq1A-1jfiA:
undetectable		 1vq1A-1jfiA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o6d HYPOTHETICAL UPF0247
PROTEIN TM0844

(Thermotoga
maritima) 		PF02590
(SPOUT_MTase) 		5 THR A 129
GLY A 101
ILE A  99
THR A  53
GLU A 107
 None
 1.14A 1vq1A-1o6dA:
undetectable		 1vq1A-1o6dA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1poi GLUTACONATE COENZYME
A-TRANSFERASE

(Acidaminococcus
fermentans) 		PF01144
(CoA_trans) 		5 THR B 225
GLY B 196
THR B 215
PRO B 218
ALA B 234
 None
 1.41A 1vq1A-1poiB:
undetectable		 1vq1A-1poiB:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgd PROTEIN
(TRANSKETOLASE)

(Escherichia
coli) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 THR A 132
GLY A 377
ILE A 396
GLU A 411
ALA A 418
 None
 1.41A 1vq1A-1qgdA:
4.1		 1vq1A-1qgdA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)

(Homo sapiens) 		PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N) 		5 ILE A 218
ALA A 176
ILE A 179
THR A 215
GLU A 220
 None
None
VIV  A 301 ( 4.0A)
None
None
 1.29A 1vq1A-1r5lA:
undetectable		 1vq1A-1r5lA:
26.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s4e GALACTOKINASE

(Pyrococcus
furiosus) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		5 ILE A  15
GLY A 299
ALA A 313
ILE A 312
GLU A 250
 None
 1.12A 1vq1A-1s4eA:
undetectable		 1vq1A-1s4eA:
24.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sg9 HEMK PROTEIN

(Thermotoga
maritima) 		PF05175
(MTS) 		12 PHE A 100
THR A 106
ILE A 128
GLY A 131
ALA A 134
ILE A 135
THR A 150
VAL A 152
GLU A 179
PHE A 180
PRO A 199
ALA A 218
 SAM  A 301 ( 3.4A)
SAM  A 301 (-3.4A)
None
SAM  A 301 ( 3.8A)
SAM  A 301 ( 4.0A)
SAM  A 301 (-4.8A)
None
SAM  A 301 (-4.3A)
None
SAM  A 301 (-3.5A)
SAM  A 301 ( 4.6A)
SAM  A 301 (-3.3A)
 0.22A 1vq1A-1sg9A:
39.6		 1vq1A-1sg9A:
95.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w0m TRIOSEPHOSPHATE
ISOMERASE

(Thermoproteus
tenax) 		PF00121
(TIM)
PF05690
(ThiG) 		5 GLY A 179
ALA A 139
ILE A 177
GLU A 217
ALA A 202
 None
None
None
None
PO4  A1226 (-3.6A)
 0.95A 1vq1A-1w0mA:
undetectable		 1vq1A-1w0mA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y5e MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
B

(Bacillus cereus) 		PF00994
(MoCF_biosynth) 		5 PHE A 109
THR A  82
GLY A 106
ILE A  91
ALA A 150
 None
 1.24A 1vq1A-1y5eA:
2.3		 1vq1A-1y5eA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3t PROTEIN
METHYLTRANSFERASE
HEMK

(Escherichia
coli) 		PF13847
(Methyltransf_31) 		6 THR A  95
GLY A 119
ALA A 122
ILE A 123
PRO A 185
ALA A 206
 SAH  A 300 ( 4.3A)
SAH  A 300 (-3.5A)
SAH  A 300 (-3.4A)
None
SAH  A 300 ( 3.9A)
SAH  A 300 (-3.4A)
 0.48A 1vq1A-2b3tA:
30.1		 1vq1A-2b3tA:
28.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1

(Saccharomyces
cerevisiae) 		PF00809
(Pterin_bind)
PF01288
(HPPK) 		5 THR A 597
ILE A 679
GLY A 757
ILE A 657
VAL A 800
 PMM  A1865 (-3.9A)
PMM  A1865 ( 4.7A)
PMM  A1865 ( 4.8A)
PMM  A1865 (-4.8A)
None
 1.45A 1vq1A-2bmbA:
undetectable		 1vq1A-2bmbA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cjw GTP-BINDING PROTEIN
GEM

(Homo sapiens) 		PF00071
(Ras) 		5 PHE A 232
THR A 220
GLY A 234
ILE A 218
VAL A 239
 None
 1.16A 1vq1A-2cjwA:
undetectable		 1vq1A-2cjwA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cxe RIBULOSE
BISPHOSPHATE
CARBOXYLASE

(Pyrococcus
horikoshii) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 GLY A 349
ALA A 371
ILE A 369
THR A 312
GLU A 325
 None
 1.20A 1vq1A-2cxeA:
undetectable		 1vq1A-2cxeA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fwm 2,3-DIHYDRO-2,3-DIHY
DROXYBENZOATE
DEHYDROGENASE

(Escherichia
coli) 		PF13561
(adh_short_C2) 		5 THR X  11
GLY X 105
ALA X 107
THR X  99
GLU X  94
 None
 1.25A 1vq1A-2fwmX:
5.6		 1vq1A-2fwmX:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fwm 2,3-DIHYDRO-2,3-DIHY
DROXYBENZOATE
DEHYDROGENASE

(Escherichia
coli) 		PF13561
(adh_short_C2) 		5 THR X  11
ILE X  82
ALA X 107
THR X  99
GLU X  94
 None
 1.23A 1vq1A-2fwmX:
5.6		 1vq1A-2fwmX:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g8l 287AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii) 		PF01937
(DUF89) 		5 PHE A 227
GLY A 212
ILE A 215
GLU A 195
ALA A 182
 None
 1.32A 1vq1A-2g8lA:
5.5		 1vq1A-2g8lA:
26.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN

(Homo sapiens) 		PF05971
(Methyltransf_10) 		5 ILE A  72
GLY A  75
THR A  95
VAL A  97
PRO A 149
 None
SAH  A 300 (-3.6A)
SAH  A 300 (-4.3A)
SAH  A 300 (-4.2A)
SAH  A 300 (-4.0A)
 0.48A 1vq1A-2h00A:
17.7		 1vq1A-2h00A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hjr MALATE DEHYDROGENASE

(Cryptosporidium
parvum) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ILE A  88
ALA A 247
ILE A  29
THR A 131
PHE A 141
 None
None
None
APR  A3001 (-2.5A)
None
 1.32A 1vq1A-2hjrA:
3.8		 1vq1A-2hjrA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ht6 GTP-BINDING PROTEIN
GEM

(Homo sapiens) 		PF00071
(Ras) 		5 PHE A 232
THR A 220
GLY A 234
ILE A 218
VAL A 239
 None
 1.26A 1vq1A-2ht6A:
undetectable		 1vq1A-2ht6A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogj DIHYDROOROTASE

(Agrobacterium
fabrum) 		PF01979
(Amidohydro_1) 		5 THR A 326
ILE A 263
VAL A 301
PHE A 270
ALA A 305
 None
 1.31A 1vq1A-2ogjA:
undetectable		 1vq1A-2ogjA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uvk YJHT

(Escherichia
coli) 		PF01344
(Kelch_1) 		5 ILE A 206
GLY A 245
ALA A 261
VAL A 113
ALA A 192
 None
 1.22A 1vq1A-2uvkA:
undetectable		 1vq1A-2uvkA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8z 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING

(Geobacillus
stearothermophilus) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		5 ILE A 280
GLY A 421
ALA A 423
GLU A 189
ALA A 286
 None
None
None
6PG  A1470 (-3.7A)
None
 1.33A 1vq1A-2w8zA:
6.9		 1vq1A-2w8zA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynm LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT B

(Prochlorococcus
marinus) 		PF00148
(Oxidored_nitro)
PF08369
(PCP_red) 		5 ILE D 188
GLY D 173
ALA D 203
ILE D 202
VAL D 248
 None
 1.18A 1vq1A-2ynmD:
2.6		 1vq1A-2ynmD:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5f DIHYDRODIPICOLINATE
SYNTHASE

(Clostridium
botulinum) 		PF00701
(DHDPS) 		5 ILE A  61
GLY A  47
ALA A  10
ILE A  41
GLU A  54
 None
None
KPI  A 162 ( 3.4A)
None
None
 1.47A 1vq1A-3a5fA:
undetectable		 1vq1A-3a5fA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5f DIHYDRODIPICOLINATE
SYNTHASE

(Clostridium
botulinum) 		PF00701
(DHDPS) 		5 ILE A  61
GLY A  47
ALA A  10
ILE A  41
GLU A  59
 None
None
KPI  A 162 ( 3.4A)
None
None
 1.43A 1vq1A-3a5fA:
undetectable		 1vq1A-3a5fA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bfn KINESIN-LIKE PROTEIN
KIF22

(Homo sapiens) 		PF00225
(Kinesin) 		5 THR A 136
GLY A 127
ALA A 125
ILE A 342
ALA A 346
 None
 1.13A 1vq1A-3bfnA:
undetectable		 1vq1A-3bfnA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ct4 PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK

(Lactococcus
lactis) 		PF02733
(Dak1) 		5 GLY A 190
ALA A 139
ILE A 138
VAL A 260
ALA A 153
 None
 1.42A 1vq1A-3ct4A:
undetectable		 1vq1A-3ct4A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6n DIHYDROOROTASE

(Aquifex
aeolicus) 		PF01979
(Amidohydro_1) 		5 PHE A  87
ILE A 354
GLY A  56
ILE A 349
THR A 366
 None
 1.02A 1vq1A-3d6nA:
undetectable		 1vq1A-3d6nA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE

(Neisseria
meningitidis) 		PF01048
(PNP_UDP_1) 		5 ILE A  65
GLY A  10
ILE A 182
GLU A  38
PHE A  69
 None
 1.44A 1vq1A-3eeiA:
undetectable		 1vq1A-3eeiA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evz METHYLTRANSFERASE

(Pyrococcus
furiosus) 		PF05175
(MTS) 		5 ILE A  87
GLY A  90
THR A 110
VAL A 112
PRO A 157
 None
 0.56A 1vq1A-3evzA:
18.3		 1vq1A-3evzA:
26.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gei TRNA MODIFICATION
GTPASE MNME

(Chlorobaculum
tepidum) 		PF01926
(MMR_HSR1)
PF10396
(TrmE_N)
PF12631
(MnmE_helical) 		5 THR A  89
ILE A  29
GLY A 472
THR A  20
ALA A  16
 None
 1.04A 1vq1A-3geiA:
undetectable		 1vq1A-3geiA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ip1 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING

(Thermotoga
maritima) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 220
ALA A 287
ILE A 223
VAL A 247
ALA A 252
 None
 1.14A 1vq1A-3ip1A:
6.1		 1vq1A-3ip1A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jab IGG1-KAPPA 2E8 HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLY H 104
VAL H   2
GLU H   1
PRO H 101
ALA H  94
 None
 1.39A 1vq1A-3jabH:
undetectable		 1vq1A-3jabH:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Thermus
thermophilus) 		PF01425
(Amidase) 		5 PHE E 114
GLY E 115
THR E 120
PHE E 126
ALA E  78
 None
 1.22A 1vq1A-3kfuE:
undetectable		 1vq1A-3kfuE:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kkl PROBABLE CHAPERONE
PROTEIN HSP33

(Saccharomyces
cerevisiae) 		no annotation 5 THR A 227
ILE A  31
ALA A 136
ILE A 137
ALA A   6
 None
 1.33A 1vq1A-3kklA:
2.5		 1vq1A-3kklA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkb HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA

(Isurus
oxyrinchus;
Isurus
oxyrinchus) 		PF00042
(Globin)
PF00042
(Globin) 		5 PHE A  33
ILE B 121
ALA A  28
GLU B   7
PRO A  37
 None
 1.16A 1vq1A-3mkbA:
undetectable		 1vq1A-3mkbA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozb METHYLTHIOADENOSINE
PHOSPHORYLASE

(Pseudomonas
aeruginosa) 		PF01048
(PNP_UDP_1) 		5 GLY A 201
ALA A  97
ILE A  21
GLU A 127
ALA A 206
 None
 1.44A 1vq1A-3ozbA:
undetectable		 1vq1A-3ozbA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p54 ENVELOPE
GLYCOPROTEIN

(Japanese
encephalitis
virus) 		PF00869
(Flavi_glycoprot)
PF02832
(Flavi_glycop_C) 		5 ILE A  33
ALA A 164
ILE A 141
THR A  32
GLU A  13
 None
 1.44A 1vq1A-3p54A:
undetectable		 1vq1A-3p54A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s46 ALANINE RACEMASE

(Streptococcus
pneumoniae) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 ILE A 130
GLY A 135
ILE A 137
PHE A 184
ALA A 167
 KCX  A 129 ( 3.8A)
None
KCX  A 129 ( 4.5A)
None
None
 1.39A 1vq1A-3s46A:
undetectable		 1vq1A-3s46A:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3um1 BRO1
DOMAIN-CONTAINING
PROTEIN BROX

(Homo sapiens) 		PF03097
(BRO1) 		5 ILE A 271
GLY A 258
VAL A 316
PHE A 332
ALA A 277
 None
 1.32A 1vq1A-3um1A:
undetectable		 1vq1A-3um1A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3um9 HALOACID
DEHALOGENASE, TYPE
II

(Polaromonas sp.
JS666) 		PF13419
(HAD_2) 		5 PHE A 173
THR A  14
ILE A 194
VAL A 206
ALA A 184
 None
 1.30A 1vq1A-3um9A:
2.7		 1vq1A-3um9A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vot L-AMINO ACID LIGASE,
BL00235

(Bacillus
licheniformis) 		PF13535
(ATP-grasp_4) 		5 GLY A 264
ALA A 262
ILE A 119
PHE A 104
ALA A 289
 None
 1.20A 1vq1A-3votA:
undetectable		 1vq1A-3votA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9h ACRIFLAVINE
RESISTANCE PROTEIN B

(Escherichia
coli) 		PF00873
(ACR_tran) 		5 THR A 595
ILE A 278
ALA A 627
GLU A 152
PRO A 285
 None
 1.37A 1vq1A-3w9hA:
undetectable		 1vq1A-3w9hA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE

(Escherichia
coli) 		no annotation 5 ILE B 193
GLY B 209
ALA B  51
VAL B 165
ALA B  65
 None
 1.40A 1vq1A-3wlxB:
4.4		 1vq1A-3wlxB:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING

(Desulfovibrio
vulgaris) 		PF00374
(NiFeSe_Hases) 		5 PHE B 210
ILE B 109
ALA B 388
THR B 105
GLU B 196
 None
 1.35A 1vq1A-3ze7B:
undetectable		 1vq1A-3ze7B:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0a PROTEIN WNT-8

(Xenopus laevis) 		PF00110
(wnt) 		5 THR B 176
GLY B 169
ILE B 205
GLU B  85
PHE B  59
 None
 1.47A 1vq1A-4f0aB:
undetectable		 1vq1A-4f0aB:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f32 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Burkholderia
vietnamiensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 GLY A 197
ALA A 114
VAL A 249
GLU A 251
ALA A  89
 None
 1.36A 1vq1A-4f32A:
undetectable		 1vq1A-4f32A:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f9o HEXOKINASE-1

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 PHE A 515
ALA A 613
THR A 905
VAL A 907
GLU A 524
 None
 1.30A 1vq1A-4f9oA:
undetectable		 1vq1A-4f9oA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Rickettsia
rickettsii) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 GLY A 203
ALA A 183
ILE A 184
VAL A  18
ALA A  94
 None
 1.15A 1vq1A-4jgaA:
undetectable		 1vq1A-4jgaA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kzp OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN

(Mycolicibacterium
smegmatis) 		PF00106
(adh_short) 		5 ILE A  81
ALA A  55
ILE A  54
THR A  28
VAL A  26
 None
 1.38A 1vq1A-4kzpA:
3.1		 1vq1A-4kzpA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mla CYTOKININ OXIDASE 2

(Zea mays) 		PF01565
(FAD_binding_4)
PF09265
(Cytokin-bind) 		5 ILE A 223
ILE A 502
VAL A 199
GLU A 191
ALA A  77
 FAD  A 601 (-4.6A)
None
None
None
None
 1.40A 1vq1A-4mlaA:
undetectable		 1vq1A-4mlaA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6m AF2299, A
CDP-ALCOHOL
PHOSPHOTRANSFERASE

(Archaeoglobus
fulgidus) 		PF01066
(CDP-OH_P_transf) 		5 ILE A 246
GLY A 265
ALA A 325
ILE A 324
PRO A 317
 None
None
MPG  A 407 ( 3.9A)
None
None
 1.14A 1vq1A-4o6mA:
undetectable		 1vq1A-4o6mA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozq CHIMERA OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND KINESIN FAMILY
MEMBER 14 PROTEIN

(Escherichia
coli;
Mus musculus) 		PF00225
(Kinesin)
PF13416
(SBP_bac_8) 		5 THR A 491
GLY A 482
ALA A 480
ILE A 710
PHE A 436
 None
 1.50A 1vq1A-4ozqA:
undetectable		 1vq1A-4ozqA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfz 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
DELTA-ISOMERASE

(Mycolicibacterium
smegmatis) 		PF01557
(FAA_hydrolase)
PF10370
(DUF2437) 		5 GLY A 189
ALA A  74
THR A 269
VAL A 264
ALA A 136
 None
 1.23A 1vq1A-4pfzA:
undetectable		 1vq1A-4pfzA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pka PATATIN-17

(Solanum
cardiophyllum) 		PF01734
(Patatin) 		5 THR X 187
ILE X  73
ILE X 152
THR X 148
PHE X  70
 MIS  X  77 ( 3.0A)
None
None
None
None
 1.43A 1vq1A-4pkaX:
2.0		 1vq1A-4pkaX:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4twb RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE

(Sulfolobus
solfataricus) 		PF00156
(Pribosyltran)
PF13793
(Pribosyltran_N) 		5 ALA A 163
ILE A 214
GLU A 154
PRO A 159
ALA A 181
 None
 1.32A 1vq1A-4twbA:
3.3		 1vq1A-4twbA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wwh ABC TRANSPORTER

(Mycolicibacterium
smegmatis) 		PF13407
(Peripla_BP_4) 		5 THR A 132
ILE A 123
ILE A 129
VAL A  41
PRO A 121
 None
 1.12A 1vq1A-4wwhA:
3.2		 1vq1A-4wwhA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2o NITRATE TRANSPORTER
1.1

(Arabidopsis
thaliana) 		PF00854
(PTR2) 		5 GLY A 430
ILE A 479
VAL A 548
PHE A 513
ALA A 553
 None
 1.24A 1vq1A-5a2oA:
undetectable		 1vq1A-5a2oA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d19 TETR FAMILY
TRANSCRIPTIONAL
REGULATOR

(Mycobacterium
tuberculosis) 		PF00440
(TetR_N)
PF13977
(TetR_C_6) 		5 PHE A  74
ALA A 138
ILE A 137
VAL A 128
ALA A  70
 None
 1.33A 1vq1A-5d19A:
undetectable		 1vq1A-5d19A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dds CRMG

(Actinoalloteichus
sp. WH1-2216-6) 		PF00202
(Aminotran_3) 		5 GLY A 320
ALA A 345
ILE A 346
THR A 341
VAL A 314
 None
 1.38A 1vq1A-5ddsA:
2.5		 1vq1A-5ddsA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h83 HETEROYOHIMBINE
SYNTHASE HYS

(Catharanthus
roseus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 PHE A  26
THR A  50
ALA A 333
ILE A 337
ALA A  19
 None
 1.22A 1vq1A-5h83A:
4.7		 1vq1A-5h83A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kom PUTATIVE FLUORIDE
ION TRANSPORTER CRCB

(Escherichia
coli) 		PF02537
(CRCB) 		5 GLY A  75
ALA A  44
ILE A  47
VAL A   8
PHE A  64
 NA  A 201 (-4.4A)
F  A 203 ( 4.3A)
None
None
None
 1.35A 1vq1A-5komA:
undetectable		 1vq1A-5komA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uan RETINOIC ACID
RECEPTOR BETA

(Homo sapiens) 		no annotation 5 ILE B 370
GLY B 320
ALA B 324
ILE B 325
GLU B 313
 None
 0.78A 1vq1A-5uanB:
undetectable		 1vq1A-5uanB:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uy7 PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE

(Burkholderia
ambifaria) 		PF00905
(Transpeptidase) 		5 THR A 559
GLY A 519
ALA A 521
ILE A 528
PHE A 427
 None
 1.46A 1vq1A-5uy7A:
undetectable		 1vq1A-5uy7A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uy7 PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE

(Burkholderia
ambifaria) 		PF00905
(Transpeptidase) 		5 THR A 559
GLY A 519
ALA A 521
ILE A 528
THR A 434
 None
 1.19A 1vq1A-5uy7A:
undetectable		 1vq1A-5uy7A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zya SPLICING FACTOR 3B
SUBUNIT 1

(Homo sapiens) 		no annotation 5 ALA C 999
ILE C1000
VAL C 989
GLU C 984
ALA C 951
 None
 1.22A 1vq1A-5zyaC:
undetectable		 1vq1A-5zyaC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zya SPLICING FACTOR 3B
SUBUNIT 1

(Homo sapiens) 		no annotation 5 GLY C 995
ALA C 999
ILE C1000
VAL C 989
GLU C 984
 None
 1.33A 1vq1A-5zyaC:
undetectable		 1vq1A-5zyaC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bx4 FLUORIDE ION
TRANSPORTER CRCB

(Escherichia
coli) 		no annotation 5 GLY A  75
ALA A  44
ILE A  47
VAL A   8
PHE A  64
 NA  A 204 (-4.4A)
F  A 201 ( 4.2A)
None
None
None
 1.31A 1vq1A-6bx4A:
undetectable		 1vq1A-6bx4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d4j PROTEIN PATCHED
HOMOLOG 1

(Homo sapiens) 		no annotation 5 PHE A 573
ALA A 562
ILE A 565
GLU A 127
ALA A 498
 None
 1.49A 1vq1A-6d4jA:
2.3		 1vq1A-6d4jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6k POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Acinetobacter
baumannii) 		no annotation 5 ILE A  96
GLY A 151
ALA A 153
ILE A 129
THR A 135
 None
 1.45A 1vq1A-6d6kA:
undetectable		 1vq1A-6d6kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f45 -

(-) 		no annotation 5 ILE D 133
GLY D 151
ALA D 245
ILE D 244
GLU D  94
 None
 1.07A 1vq1A-6f45D:
undetectable		 1vq1A-6f45D:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b2p PROTEIN (LECTIN)

(Hyacinthoides
hispanica) 		PF01453
(B_lectin) 		3 GLY A  57
ASP A  39
ASN A  55
 None
 0.61A 1vq1A-1b2pA:
undetectable		 1vq1A-1b2pA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dus MJ0882

(Methanocaldococcus
jannaschii) 		PF05175
(MTS) 		3 GLY A  63
ASP A  84
ASN A 129
 None
 0.18A 1vq1A-1dusA:
18.9		 1vq1A-1dusA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e0t PYRUVATE KINASE

(Escherichia
coli) 		PF00224
(PK)
PF02887
(PK_C) 		3 GLY A 153
ASP A  82
ASN A 155
 None
 0.64A 1vq1A-1e0tA:
4.0		 1vq1A-1e0tA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1h BOTULINUM NEUROTOXIN
TYPE A LIGHT CHAIN

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		3 GLY A  56
ASP A  57
ASN A  52
 None
 0.60A 1vq1A-1e1hA:
undetectable		 1vq1A-1e1hA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4e VANCOMYCIN/TEICOPLAN
IN A-TYPE RESISTANCE
PROTEIN VANA

(Enterococcus
faecium) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		3 GLY B 216
ASP B 232
ASN B 304
 None
None
ADP  B 350 (-3.3A)
 0.61A 1vq1A-1e4eB:
undetectable		 1vq1A-1e4eB:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5g COMPLEMENT CONTROL
PROTEIN C3

(Vaccinia virus) 		PF00084
(Sushi) 		3 GLY A  38
ASP A  91
ASN A  36
 None
 0.65A 1vq1A-1e5gA:
undetectable		 1vq1A-1e5gA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1elt ELASTASE

(Salmo salar) 		PF00089
(Trypsin) 		3 GLY A 190
ASP A 194
ASN A 188
 None
 0.47A 1vq1A-1eltA:
undetectable		 1vq1A-1eltA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1im8 YECO

(Haemophilus
influenzae) 		PF13649
(Methyltransf_25) 		3 GLY A  63
ASP A  88
ASN A 131
 SAI  A 302 (-3.8A)
SAI  A 302 (-2.8A)
SAI  A 302 (-4.1A)
 0.56A 1vq1A-1im8A:
11.8		 1vq1A-1im8A:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jpc AGGLUTININ

(Galanthus
nivalis) 		PF01453
(B_lectin) 		3 GLY A  46
ASP A  28
ASN A  44
 MAN  A 115 ( 4.7A)
MAN  A 115 (-3.1A)
MAN  A 117 (-3.1A)
 0.52A 1vq1A-1jpcA:
undetectable		 1vq1A-1jpcA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jpc AGGLUTININ

(Galanthus
nivalis) 		PF01453
(B_lectin) 		3 GLY A  78
ASP A  59
ASN A  76
 MAN  A 113 ( 4.8A)
MAN  A 113 (-3.2A)
MAN  A 114 (-3.1A)
 0.53A 1vq1A-1jpcA:
undetectable		 1vq1A-1jpcA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE

(Saccharomyces
cerevisiae) 		PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5) 		3 GLY A  72
ASP A 148
ASN A  77
 NAD  A 900 (-3.3A)
NAD  A 900 (-3.0A)
NAD  A 900 (-2.9A)
 0.51A 1vq1A-1la2A:
undetectable		 1vq1A-1la2A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lxy ARGININE DEIMINASE

(Mycoplasma
arginini) 		PF02274
(Amidinotransf) 		3 GLY A 228
ASP A 216
ASN A 260
 None
 0.62A 1vq1A-1lxyA:
undetectable		 1vq1A-1lxyA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ne2 HYPOTHETICAL PROTEIN
TA1320

(Thermoplasma
acidophilum) 		PF06325
(PrmA) 		3 GLY A  56
ASP A  78
ASN A 114
 None
 0.33A 1vq1A-1ne2A:
14.1		 1vq1A-1ne2A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nl3 PREPROTEIN
TRANSLOCASE SECA 1
SUBUNIT

(Mycobacterium
tuberculosis) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		3 GLY A 575
ASP A 576
ASN A 396
 None
 0.64A 1vq1A-1nl3A:
undetectable		 1vq1A-1nl3A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obf GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Achromobacter
xylosoxidans) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		3 GLY O 227
ASP O 226
ASN O 230
 None
 0.52A 1vq1A-1obfO:
3.3		 1vq1A-1obfO:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qdm PROPHYTEPSIN

(Hordeum vulgare) 		PF00026
(Asp)
PF03489
(SapB_2)
PF05184
(SapB_1) 		3 GLY A 225
ASP A  36
ASN A  15
 None
 0.66A 1vq1A-1qdmA:
undetectable		 1vq1A-1qdmA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qu9 YJGF PROTEIN

(Escherichia
coli) 		PF01042
(Ribonuc_L-PSP) 		3 GLY A  69
ASP A  70
ASN A  99
 None
 0.59A 1vq1A-1qu9A:
undetectable		 1vq1A-1qu9A:
17.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sg9 HEMK PROTEIN

(Thermotoga
maritima) 		PF05175
(MTS) 		3 GLY A 129
ASP A 151
ASN A 197
 SAM  A 301 (-3.3A)
SAM  A 301 (-2.9A)
GLN  A 400 ( 3.1A)
 0.10A 1vq1A-1sg9A:
39.6		 1vq1A-1sg9A:
95.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tid ANTI-SIGMA F FACTOR

(Geobacillus
stearothermophilus) 		PF13581
(HATPase_c_2) 		3 GLY A 129
ASP A  81
ASN A 127
 None
ATP  A 200 (-4.0A)
None
 0.58A 1vq1A-1tidA:
undetectable		 1vq1A-1tidA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tp8 AGGLUTININ ALPHA
CHAIN

(Artocarpus
hirsutus) 		PF01419
(Jacalin) 		3 GLY A  26
ASP A  27
ASN A  20
 None
 0.58A 1vq1A-1tp8A:
undetectable		 1vq1A-1tp8A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9n MALATE DEHYDROGENASE

(Pyrococcus
horikoshii) 		PF02615
(Ldh_2) 		3 GLY A  92
ASP A  91
ASN A 126
 None
 0.65A 1vq1A-1v9nA:
undetectable		 1vq1A-1v9nA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vko INOSITOL-3-PHOSPHATE
SYNTHASE

(Caenorhabditis
elegans) 		PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5) 		3 GLY A  71
ASP A 148
ASN A  76
 NAD  A 601 (-3.2A)
NAD  A 601 (-2.7A)
NAD  A 601 ( 2.9A)
 0.51A 1vq1A-1vkoA:
undetectable		 1vq1A-1vkoA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vm7 RIBOKINASE

(Thermotoga
maritima) 		PF00294
(PfkB) 		3 GLY A 216
ASP A 217
ASN A 178
 None
 0.62A 1vq1A-1vm7A:
3.7		 1vq1A-1vm7A:
27.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wuf HYPOTHETICAL PROTEIN
LIN2664

(Listeria
innocua) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 GLY A1347
ASP A1110
ASN A1345
 None
 0.59A 1vq1A-1wufA:
undetectable		 1vq1A-1wufA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ynq OXIDOREDUCTASE

(Bacillus
halodurans) 		PF00248
(Aldo_ket_red) 		3 GLY A  54
ASP A  49
ASN A  56
 None
 0.54A 1vq1A-1ynqA:
undetectable		 1vq1A-1ynqA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a5h L-LYSINE
2,3-AMINOMUTASE

(Clostridium
subterminale) 		PF04055
(Radical_SAM)
PF12544
(LAM_C) 		3 GLY A 264
ASP A 267
ASN A  73
 None
 0.58A 1vq1A-2a5hA:
undetectable		 1vq1A-2a5hA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aj4 GALACTOKINASE

(Saccharomyces
cerevisiae) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		3 GLY A 308
ASP A 312
ASN A 306
 None
 0.66A 1vq1A-2aj4A:
undetectable		 1vq1A-2aj4A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ark FLAVODOXIN

(Aquifex
aeolicus) 		PF00258
(Flavodoxin_1) 		3 GLY A 116
ASP A  84
ASN A 114
 None
 0.48A 1vq1A-2arkA:
2.6		 1vq1A-2arkA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3t PROTEIN
METHYLTRANSFERASE
HEMK

(Escherichia
coli) 		PF13847
(Methyltransf_31) 		3 GLY A 117
ASP A 140
ASN A 183
 SAH  A 300 (-3.4A)
SAH  A 300 (-3.1A)
SAH  A 300 (-3.9A)
 0.22A 1vq1A-2b3tA:
30.1		 1vq1A-2b3tA:
28.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1d SOXA

(Paracoccus
denitrificans) 		no annotation 3 GLY A 215
ASP A  27
ASN A 213
 None
 0.58A 1vq1A-2c1dA:
undetectable		 1vq1A-2c1dA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfc 2-(R)-HYDROXYPROPYL-
COM DEHYDROGENASE

(Xanthobacter
autotrophicus) 		PF13561
(adh_short_C2) 		3 GLY A   9
ASP A  33
ASN A  14
 NAD  A1251 (-3.5A)
NAD  A1251 (-2.7A)
NAD  A1251 (-2.7A)
 0.58A 1vq1A-2cfcA:
6.6		 1vq1A-2cfcA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2a ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B

(Staphylococcus
aureus) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N) 		3 GLY B 117
ASP B 156
ASN B 102
 None
 0.63A 1vq1A-2f2aB:
undetectable		 1vq1A-2f2aB:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT

(Thermus
thermophilus) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		3 GLY A 686
ASP A 687
ASN A 409
 None
 0.67A 1vq1A-2ipcA:
3.4		 1vq1A-2ipcA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jf4 PERIPLASMIC
TREHALASE

(Escherichia
coli) 		PF01204
(Trehalase) 		3 GLY A 244
ASP A 243
ASN A 247
 None
 0.54A 1vq1A-2jf4A:
undetectable		 1vq1A-2jf4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2krb EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B

(Homo sapiens) 		PF00076
(RRM_1) 		3 GLY A  83
ASP A  82
ASN A  22
 None
 0.67A 1vq1A-2krbA:
undetectable		 1vq1A-2krbA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mki CYTOPLASMIC
POLYADENYLATION
ELEMENT-BINDING
PROTEIN 4

(Homo sapiens) 		PF16367
(RRM_7) 		3 GLY A 198
ASP A 194
ASN A 224
 None
 0.55A 1vq1A-2mkiA:
undetectable		 1vq1A-2mkiA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8e DNA MISMATCH REPAIR
PROTEIN MSH6

(Homo sapiens) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		3 GLY B 770
ASP B1058
ASN B 534
 None
 0.65A 1vq1A-2o8eB:
2.4		 1vq1A-2o8eB:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p35 TRANS-ACONITATE
2-METHYLTRANSFERASE

(Agrobacterium
fabrum) 		PF13489
(Methyltransf_23) 		3 GLY A  38
ASP A  61
ASN A  99
 SAH  A 301 (-3.6A)
SAH  A 301 (-2.7A)
SAH  A 301 (-3.8A)
 0.59A 1vq1A-2p35A:
11.4		 1vq1A-2p35A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal disease
virus) 		PF04197
(Birna_RdRp) 		3 GLY A 481
ASP A 467
ASN A 423
 None
 0.66A 1vq1A-2pggA:
2.6		 1vq1A-2pggA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pjd RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE C

(Escherichia
coli) 		PF05175
(MTS)
PF08468
(MTS_N) 		3 GLY A 204
ASP A 227
ASN A 268
 None
 0.54A 1vq1A-2pjdA:
18.2		 1vq1A-2pjdA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po4 VIRION RNA
POLYMERASE

(Escherichia
virus N4) 		no annotation 3 GLY A 524
ASP A 525
ASN A 494
 None
 0.54A 1vq1A-2po4A:
undetectable		 1vq1A-2po4A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w5f ENDO-1,4-BETA-XYLANA
SE Y

(Ruminiclostridium
thermocellum) 		PF00331
(Glyco_hydro_10)
PF02018
(CBM_4_9) 		3 GLY A  64
ASP A 173
ASN A  62
 None
CD  A1559 (-2.1A)
None
 0.53A 1vq1A-2w5fA:
undetectable		 1vq1A-2w5fA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wed PENICILLOPEPSIN

(Penicillium
janthinellum) 		PF00026
(Asp) 		3 GLY A 207
ASP A 206
ASN A 194
 None
 0.66A 1vq1A-2wedA:
undetectable		 1vq1A-2wedA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wrt GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME 51

(Fasciola
hepatica) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		3 GLY A 138
ASP A 139
ASN A 135
 None
 0.60A 1vq1A-2wrtA:
undetectable		 1vq1A-2wrtA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xt4 MCBG-LIKE PROTEIN

(Xanthomonas
albilineans) 		PF00805
(Pentapeptide)
PF13599
(Pentapeptide_4) 		3 GLY A 149
ASP A 129
ASN A 167
 None
 0.60A 1vq1A-2xt4A:
undetectable		 1vq1A-2xt4A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yo3 GENERAL CONTROL
PROTEIN GCN4,
PUTATIVE INNER
MEMBRANE PROTEIN,
GENERAL CONTROL
PROTEIN GCN4

(Saccharomyces
cerevisiae;
Salmonella
enterica) 		PF05662
(YadA_stalk) 		3 GLY A1331
ASP A1332
ASN A1329
 None
 0.64A 1vq1A-2yo3A:
undetectable		 1vq1A-2yo3A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0e MANNOSE/SIALIC
ACID-BINDING LECTIN

(Polygonatum
cyrtonema) 		PF01453
(B_lectin) 		3 GLY A  47
ASP A  29
ASN A  45
 SO4  A 112 ( 3.7A)
SO4  A 112 ( 2.7A)
None
 0.60A 1vq1A-3a0eA:
undetectable		 1vq1A-3a0eA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bs9 NUCLEOLYSIN TIA-1
ISOFORM P40

(Homo sapiens) 		PF00076
(RRM_1) 		3 GLY A 100
ASP A 101
ASN A 169
 None
 0.65A 1vq1A-3bs9A:
undetectable		 1vq1A-3bs9A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxz PREPROTEIN
TRANSLOCASE SUBUNIT
SECA

(Escherichia
coli) 		PF07517
(SecA_DEAD) 		3 GLY A 579
ASP A 580
ASN A 415
 None
 0.65A 1vq1A-3bxzA:
3.4		 1vq1A-3bxzA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ccf CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE

(Trichormus
variabilis) 		PF08241
(Methyltransf_11) 		3 GLY A  46
ASP A  67
ASN A 105
 None
 0.38A 1vq1A-3ccfA:
12.0		 1vq1A-3ccfA:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cjt RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF06325
(PrmA) 		3 GLY A 128
ASP A 149
ASN A 191
 SAH  A 258 (-3.1A)
SAH  A 258 (-2.8A)
SAH  A 258 ( 3.8A)
 0.26A 1vq1A-3cjtA:
16.9		 1vq1A-3cjtA:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cz8 PUTATIVE
SPORULATION-SPECIFIC
GLYCOSYLASE YDHD

(Bacillus
subtilis) 		PF00704
(Glyco_hydro_18) 		3 GLY A 139
ASP A 140
ASN A 184
 None
 0.66A 1vq1A-3cz8A:
undetectable		 1vq1A-3cz8A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkh LACCASE-1

(Melanocarpus
albomyces) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 GLY A 558
ASP A 556
ASN A 109
 None
 0.60A 1vq1A-3dkhA:
undetectable		 1vq1A-3dkhA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dpr PROTEIN VP2

(Rhinovirus A) 		PF00073
(Rhv) 		3 GLY B  19
ASP B  20
ASN B  61
 None
 0.65A 1vq1A-3dprB:
undetectable		 1vq1A-3dprB:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dx5 UNCHARACTERIZED
PROTEIN ASBF

(Bacillus
anthracis) 		PF01261
(AP_endonuc_2) 		3 GLY A  36
ASP A  69
ASN A  41
 None
 0.61A 1vq1A-3dx5A:
undetectable		 1vq1A-3dx5A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzw AGGLUTININ

(Narcissus
pseudonarcissus) 		PF01453
(B_lectin) 		3 GLY A  46
ASP A  28
ASN A  44
 MAN  A 113 ( 4.7A)
MAN  A 113 (-3.1A)
None
 0.58A 1vq1A-3dzwA:
undetectable		 1vq1A-3dzwA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzw AGGLUTININ

(Narcissus
pseudonarcissus) 		PF01453
(B_lectin) 		3 GLY A  78
ASP A  59
ASN A  76
 MAN  A 115 ( 4.8A)
MAN  A 115 (-2.9A)
None
 0.55A 1vq1A-3dzwA:
undetectable		 1vq1A-3dzwA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e8s PUTATIVE SAM
DEPENDENT
METHYLTRANSFERASE

(Pseudomonas
putida) 		PF13489
(Methyltransf_23) 		3 GLY A  59
ASP A  80
ASN A 122
 SAH  A 300 (-4.2A)
SAH  A 300 (-2.7A)
SAH  A 300 (-3.8A)
 0.54A 1vq1A-3e8sA:
11.3		 1vq1A-3e8sA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ee1 EFFECTOR PROTEIN
VIRA

(Shigella
flexneri) 		PF06872
(EspG) 		3 GLY A  76
ASP A  75
ASN A 130
 None
 0.66A 1vq1A-3ee1A:
undetectable		 1vq1A-3ee1A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fna POSSIBLE ARABINOSE
5-PHOSPHATE
ISOMERASE

(Escherichia
coli) 		PF00571
(CBS) 		3 GLY A 245
ASP A 262
ASN A 243
 None
 0.67A 1vq1A-3fnaA:
undetectable		 1vq1A-3fnaA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1w SUGAR ABC
TRANSPORTER

(Bacillus
halodurans) 		PF13407
(Peripla_BP_4) 		3 GLY A 239
ASP A 242
ASN A 235
 None
 0.60A 1vq1A-3g1wA:
4.6		 1vq1A-3g1wA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gef LAMIN-A/C

(Homo sapiens) 		PF00932
(LTD) 		3 GLY A 474
ASP A 476
ASN A 524
 None
 0.64A 1vq1A-3gefA:
undetectable		 1vq1A-3gefA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3grz RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE

(Lactobacillus
delbrueckii) 		PF06325
(PrmA) 		3 GLY A 184
ASP A 206
ASN A 248
 GOL  A 322 ( 3.7A)
GOL  A 322 (-3.5A)
None
 0.24A 1vq1A-3grzA:
16.0		 1vq1A-3grzA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT

(Saccharomyces
cerevisiae) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		3 GLY A 930
ASP A 953
ASN A 932
 None
 0.65A 1vq1A-3iayA:
undetectable		 1vq1A-3iayA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibz PUTATIVE TELLURIUM
RESISTANT LIKE
PROTEIN TERD

(Streptomyces
coelicolor) 		PF02342
(TerD) 		3 GLY A  28
ASP A  88
ASN A 126
 CA  A 193 ( 4.9A)
CA  A 193 (-2.3A)
None
 0.62A 1vq1A-3ibzA:
undetectable		 1vq1A-3ibzA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jc7 DNA REPLICATION
COMPLEX GINS PROTEIN
SLD5

(Saccharomyces
cerevisiae) 		PF05916
(Sld5)
PF16922
(SLD5_C) 		3 GLY D 104
ASP D 107
ASN D 100
 None
 0.50A 1vq1A-3jc7D:
undetectable		 1vq1A-3jc7D:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mml ALLOPHANATE
HYDROLASE SUBUNIT 2
ALLOPHANATE
HYDROLASE SUBUNIT 1

(Mycolicibacterium
smegmatis;
Mycolicibacterium
smegmatis) 		PF02626
(CT_A_B)
PF02682
(CT_C_D) 		3 GLY A 183
ASP A 186
ASN B   8
 None
 0.62A 1vq1A-3mmlA:
undetectable		 1vq1A-3mmlA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3na6 SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE

(Ruegeria sp.
TM1040) 		PF04952
(AstE_AspA) 		3 GLY A  59
ASP A  60
ASN A  57
 None
 0.64A 1vq1A-3na6A:
undetectable		 1vq1A-3na6A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nnk UREIDOGLYCINE-GLYOXY
LATE
AMINOTRANSFERASE

(Klebsiella
pneumoniae) 		PF00266
(Aminotran_5) 		3 GLY A 299
ASP A 300
ASN A 323
 None
 0.56A 1vq1A-3nnkA:
4.1		 1vq1A-3nnkA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o31 THERMONICOTIANAMINE
SYNTHASE

(Methanothermobacter
thermautotrophicus) 		PF03059
(NAS) 		3 GLY A 173
ASP A 172
ASN A 175
 None
 0.63A 1vq1A-3o31A:
12.0		 1vq1A-3o31A:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE ALPHA-SUBUNIT

(Komagataella
pastoris) 		PF00365
(PFK) 		3 GLY A 750
ASP A 753
ASN A 746
 None
 0.59A 1vq1A-3opyA:
undetectable		 1vq1A-3opyA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8s JACALIN

(Artocarpus
heterophyllus) 		PF01419
(Jacalin) 		3 GLY A  50
ASP A  51
ASN A  44
 None
 0.59A 1vq1A-3p8sA:
undetectable		 1vq1A-3p8sA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pg5 UNCHARACTERIZED
PROTEIN

(Corynebacterium
diphtheriae) 		PF13614
(AAA_31) 		3 GLY A 162
ASP A  39
ASN A   8
 None
 0.65A 1vq1A-3pg5A:
undetectable		 1vq1A-3pg5A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q87 N6 ADENINE SPECIFIC
DNA METHYLASE

(Encephalitozoon
cuniculi) 		PF05175
(MTS) 		3 GLY B  31
ASP B  51
ASN B  85
 SAM  B 300 (-3.5A)
SAM  B 300 (-2.9A)
SAM  B 300 (-3.9A)
 0.31A 1vq1A-3q87B:
17.7		 1vq1A-3q87B:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3se7 VANA

(-) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		3 GLY A 213
ASP A 229
ASN A 301
 None
None
ATP  A 400 ( 2.9A)
 0.52A 1vq1A-3se7A:
undetectable		 1vq1A-3se7A:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3suj CERATO-PLATANIN 1

(Moniliophthora
perniciosa) 		PF07249
(Cerato-platanin) 		3 GLY A  56
ASP A  57
ASN A  31
 None
 0.65A 1vq1A-3sujA:
undetectable		 1vq1A-3sujA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3te6 REGULATORY PROTEIN
SIR3

(Saccharomyces
cerevisiae) 		no annotation 3 GLY A 797
ASP A 581
ASN A 794
 None
 0.30A 1vq1A-3te6A:
undetectable		 1vq1A-3te6A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thz DNA MISMATCH REPAIR
PROTEIN MSH2

(Homo sapiens) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		3 GLY A 338
ASP A 603
ASN A 343
 None
 0.66A 1vq1A-3thzA:
2.9		 1vq1A-3thzA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u37 ACETYL-XYLAN
ESTERASE EST2A

(Butyrivibrio
proteoclasticus) 		PF13472
(Lipase_GDSL_2) 		3 GLY A 194
ASP A 196
ASN A 202
 None
 0.62A 1vq1A-3u37A:
undetectable		 1vq1A-3u37A:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5n PUTATIVE
RHAMNOSIDASE

(Streptomyces
avermitilis) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		3 GLY A 696
ASP A 697
ASN A 690
 None
 0.65A 1vq1A-3w5nA:
undetectable		 1vq1A-3w5nA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wia NITRITE REDUCTASE

(Geobacillus
kaustophilus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 GLY A 276
ASP A 256
ASN A 234
 None
 0.50A 1vq1A-3wiaA:
undetectable		 1vq1A-3wiaA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wkq NITRITE REDUCTASE

(Geobacillus
thermodenitrificans) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 GLY A 276
ASP A 256
ASN A 234
 None
 0.50A 1vq1A-3wkqA:
undetectable		 1vq1A-3wkqA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wme ATP-BINDING
CASSETTE, SUB-FAMILY
B, MEMBER 1

(Cyanidioschyzon
merolae) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		3 GLY A 635
ASP A 634
ASN A 470
 None
 0.62A 1vq1A-3wmeA:
2.6		 1vq1A-3wmeA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4afr METACASPASE

(Trypanosoma
brucei) 		PF00656
(Peptidase_C14) 		3 GLY A  19
ASP A  16
ASN A  24
 None
 0.59A 1vq1A-4afrA:
undetectable		 1vq1A-4afrA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc7 ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE,
PEROXISOMAL

(Cavia porcellus) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		3 GLY A 327
ASP A 331
ASN A 324
 None
 0.52A 1vq1A-4bc7A:
undetectable		 1vq1A-4bc7A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d5g CYCLOHEXANE-1,2-DION
E HYDROLASE

(Azoarcus sp.
BH72) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 GLY A 290
ASP A 284
ASN A 562
 None
 0.66A 1vq1A-4d5gA:
2.5		 1vq1A-4d5gA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dcm RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G

(Escherichia
coli) 		PF05175
(MTS) 		3 GLY A 236
ASP A 259
ASN A 305
 SAM  A 401 (-3.5A)
SAM  A 401 (-2.9A)
SAM  A 401 (-3.8A)
 0.27A 1vq1A-4dcmA:
17.1		 1vq1A-4dcmA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4j ARGININE DEIMINASE

(Mycoplasma
penetrans) 		PF02274
(Amidinotransf) 		3 GLY A 272
ASP A 260
ASN A 304
 None
 0.63A 1vq1A-4e4jA:
undetectable		 1vq1A-4e4jA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f3n UNCHARACTERIZED ACR,
COG1565 SUPERFAMILY

(Burkholderia
thailandensis) 		PF02636
(Methyltransf_28) 		3 GLY A 349
ASP A 352
ASN A 347
 None
 0.53A 1vq1A-4f3nA:
10.2		 1vq1A-4f3nA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g41 MTA/SAH NUCLEOSIDASE

(Streptococcus
pyogenes) 		PF01048
(PNP_UDP_1) 		3 GLY A 143
ASP A  93
ASN A 167
 GLY  A 143 ( 0.0A)
ASP  A  93 ( 0.6A)
ASN  A 167 ( 0.6A)
 0.62A 1vq1A-4g41A:
undetectable		 1vq1A-4g41A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gek TRNA
(CMO5U34)-METHYLTRAN
SFERASE

(Escherichia
coli) 		PF13649
(Methyltransf_25) 		3 GLY A  64
ASP A  89
ASN A 132
 GEK  A 302 (-3.7A)
GEK  A 302 (-2.8A)
GEK  A 302 (-3.7A)
 0.61A 1vq1A-4gekA:
12.2		 1vq1A-4gekA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4isc METHYLTRANSFERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF05401
(NodS) 		3 GLY A  50
ASP A  71
ASN A  53
 BME  A 301 ( 4.7A)
None
None
 0.66A 1vq1A-4iscA:
10.7		 1vq1A-4iscA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iwn TRNA
(CMO5U34)-METHYLTRAN
SFERASE

(Escherichia
coli) 		PF13649
(Methyltransf_25) 		3 GLY A  64
ASP A  89
ASN A 132
 GEK  A 301 (-3.6A)
GEK  A 301 (-2.8A)
GEK  A 301 (-3.7A)
 0.59A 1vq1A-4iwnA:
12.4		 1vq1A-4iwnA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jnd CA(2+)/CALMODULIN-DE
PENDENT PROTEIN
KINASE PHOSPHATASE

(Caenorhabditis
elegans) 		PF00481
(PP2C) 		3 GLY A 371
ASP A 374
ASN A 416
 None
 0.61A 1vq1A-4jndA:
2.3		 1vq1A-4jndA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1

(Haemonchus
contortus) 		PF08241
(Methyltransf_11) 		3 GLY A  59
ASP A  80
ASN A 122
 SAH  A 502 (-3.6A)
SAH  A 502 (-2.5A)
SAH  A 502 (-3.9A)
 0.46A 1vq1A-4krgA:
10.7		 1vq1A-4krgA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mju NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 GLY A 297
ASP A 293
ASN A 344
 CA  A 502 (-4.7A)
None
None
 0.59A 1vq1A-4mjuA:
undetectable		 1vq1A-4mjuA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mu9 GLYCOSIDE HYDROLASE
FAMILY 73

(Bacteroides
thetaiotaomicron) 		PF03663
(Glyco_hydro_76) 		3 GLY A 358
ASP A 374
ASN A 365
 None
 0.54A 1vq1A-4mu9A:
undetectable		 1vq1A-4mu9A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mzu WXCM-LIKE PROTEIN

(Shewanella
denitrificans) 		PF00132
(Hexapep)
PF05523
(FdtA) 		3 GLY A  14
ASP A  15
ASN A  12
 None
 0.67A 1vq1A-4mzuA:
undetectable		 1vq1A-4mzuA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nnp LIPOPROTEIN

(Staphylococcus
aureus) 		PF01297
(ZnuA) 		3 GLY A  51
ASP A  52
ASN A  48
 None
 0.59A 1vq1A-4nnpA:
undetectable		 1vq1A-4nnpA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nuz ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F2

(Streptococcus
pyogenes) 		no annotation 3 GLY A 408
ASP A 407
ASN A 374
 None
 0.57A 1vq1A-4nuzA:
2.3		 1vq1A-4nuzA:
19.54