SIMILAR PATTERNS OF AMINO ACIDS FOR 1VPT_A_SAMA400_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1biu HIV-1 INTEGRASE

(Human
immunodeficiency
virus 1) 		PF00665
(rve) 		5 ILE A  73
VAL A 176
VAL A  75
ALA A  76
LEU A 158
 None
 0.79A 1vptA-1biuA:
undetectable		 1vptA-1biuA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bs9 ACETYL XYLAN
ESTERASE

(Talaromyces
purpureogenus) 		PF01083
(Cutinase) 		5 GLN A 188
GLY A  92
HIS A 187
VAL A  68
ALA A  45
 None
 1.02A 1vptA-1bs9A:
undetectable		 1vptA-1bs9A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ea9 CYCLOMALTODEXTRINASE

(Bacillus sp.
(in: Bacteria)) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		5 ILE C 136
VAL C 174
VAL C 189
ALA C 188
LEU C 181
 None
 1.01A 1vptA-1ea9C:
undetectable		 1vptA-1ea9C:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ex4 INTEGRASE

(Human
immunodeficiency
virus 1) 		PF00552
(IN_DBD_C)
PF00665
(rve) 		5 ILE A  73
VAL A 176
VAL A  75
ALA A  76
LEU A 158
 None
 0.77A 1vptA-1ex4A:
undetectable		 1vptA-1ex4A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g5g FUSION PROTEIN

(Avian
avulavirus 1) 		PF00523
(Fusion_gly) 		5 LEU A 345
TYR A 302
VAL A 319
VAL A 323
LEU A 363
 None
 0.98A 1vptA-1g5gA:
undetectable		 1vptA-1g5gA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k6y INTEGRASE

(Human
immunodeficiency
virus 1) 		PF00665
(rve)
PF02022
(Integrase_Zn) 		5 ILE A  73
VAL A 176
VAL A  75
ALA A  76
LEU A 158
 None
 0.76A 1vptA-1k6yA:
undetectable		 1vptA-1k6yA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m54 CYSTATHIONINE
BETA-SYNTHASE

(Homo sapiens) 		PF00291
(PALP) 		5 LEU A 338
ILE A 373
GLY A 348
ALA A 357
LEU A 251
 None
 1.02A 1vptA-1m54A:
1.9		 1vptA-1m54A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m9u EARTHWORM
FIBRINOLYTIC ENZYME

(Eisenia fetida) 		PF00089
(Trypsin) 		5 ILE A 181
GLY A 211
GLY A 196
VAL A 162
VAL A 210
 None
 1.06A 1vptA-1m9uA:
undetectable		 1vptA-1m9uA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mv0 MYC
BOX-DEPENDENT-INTERA
CTING PROTEIN 1

(Homo sapiens) 		PF14604
(SH3_9) 		5 ILE B 439
GLY B 454
PRO B 474
VAL B 455
LEU B 466
 None
 1.08A 1vptA-1mv0B:
undetectable		 1vptA-1mv0B:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mzj BETA-KETOACYLSYNTHAS
E III

(Streptomyces
sp. R1128) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 ILE A 316
GLY A 326
PRO A 185
GLY A 184
VAL A 233
 None
 1.05A 1vptA-1mzjA:
undetectable		 1vptA-1mzjA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rcq CATABOLIC ALANINE
RACEMASE DADX

(Pseudomonas
aeruginosa) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 GLY A 210
GLY A 215
VAL A  31
ALA A  30
LEU A  78
 PLP  A 358 (-3.3A)
None
PLP  A 358 (-4.4A)
None
PLP  A 358 ( 4.2A)
 0.96A 1vptA-1rcqA:
undetectable		 1vptA-1rcqA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u60 PROBABLE GLUTAMINASE
YBAS

(Escherichia
coli) 		PF04960
(Glutaminase) 		5 LEU A  64
ILE A 203
GLY A 265
VAL A  52
LEU A 220
 None
EDO  A1217 ( 3.8A)
None
None
None
 0.78A 1vptA-1u60A:
undetectable		 1vptA-1u60A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vzo RIBOSOMAL PROTEIN S6
KINASE ALPHA 5

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A 312
GLY A 303
VAL A 162
ALA A 235
LEU A 241
 None
None
None
BME  A1304 (-3.3A)
None
 0.90A 1vptA-1vzoA:
undetectable		 1vptA-1vzoA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa5 IMPORTIN ALPHA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00514
(Arm)
PF01749
(IBB)
PF16186
(Arm_3) 		5 LEU B 346
ILE B 326
GLY B 341
VAL B 295
ALA B 319
 None
 1.01A 1vptA-1wa5B:
undetectable		 1vptA-1wa5B:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wue MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Enterococcus
faecalis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLN A1304
LEU A1301
ILE A1036
GLY A1347
LEU A1076
 None
 1.05A 1vptA-1wueA:
undetectable		 1vptA-1wueA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xg5 ARPG836

(Homo sapiens) 		PF00106
(adh_short) 		5 ILE A  95
GLY A  99
VAL A 236
ALA A  25
LEU A  31
 None
NAP  A1301 (-3.6A)
None
None
None
 0.91A 1vptA-1xg5A:
5.4		 1vptA-1xg5A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yul PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF01467
(CTP_transf_like) 		5 LEU A  37
ILE A   5
GLY A   6
GLY A   9
ALA A  27
 None
 1.01A 1vptA-1yulA:
2.4		 1vptA-1yulA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bg5 PHOSPHOENOLPYRUVATE-
PROTEIN KINASE

(Caldanaerobacter
subterraneus) 		PF02896
(PEP-utilizers_C) 		5 LEU A 406
TYR A 390
ILE A 428
GLY A 427
VAL A 446
 None
 0.96A 1vptA-2bg5A:
undetectable		 1vptA-2bg5A:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c6r DNA-BINDING STRESS
RESPONSE PROTEIN,
DPS FAMILY

(Deinococcus
radiodurans) 		PF00210
(Ferritin) 		5 ILE A 151
GLY A 148
VAL A 172
VAL A 147
LEU A  59
 None
 0.99A 1vptA-2c6rA:
undetectable		 1vptA-2c6rA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1q LUCIFERIN
4-MONOOXYGENASE

(Luciola
cruciata) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 ILE A 351
GLY A 343
GLY A 317
VAL A 394
LEU A 399
 None
None
AMP  A1001 ( 4.3A)
None
None
 0.92A 1vptA-2d1qA:
undetectable		 1vptA-2d1qA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e9y CARBAMATE KINASE

(Aeropyrum
pernix) 		PF00696
(AA_kinase) 		5 GLY A  56
GLY A  13
VAL A 213
VAL A  59
LEU A  78
 None
 1.02A 1vptA-2e9yA:
2.5		 1vptA-2e9yA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gdq YITF

(Bacillus
subtilis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 TYR A 127
ILE A 158
VAL A 147
VAL A 160
LEU A 177
 None
 0.83A 1vptA-2gdqA:
undetectable		 1vptA-2gdqA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuy GLYCOSYLTRANSFERASE

(Streptomyces
viridochromogenes) 		PF00534
(Glycos_transf_1) 		5 GLY A 114
VAL A 339
VAL A  16
ALA A  17
LEU A  53
 None
 0.95A 1vptA-2iuyA:
2.5		 1vptA-2iuyA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jh9 VP4 CORE PROTEIN

(Bluetongue
virus) 		PF05059
(Orbi_VP4) 		6 LEU A 179
TYR A 195
ILE A 196
GLY A 197
VAL A 242
VAL A 266
 None
 0.57A 1vptA-2jh9A:
14.5		 1vptA-2jh9A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odo ALANINE RACEMASE

(Pseudomonas
fluorescens) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 GLY A 210
GLY A 215
VAL A  31
ALA A  30
LEU A  78
 LLP  A  33 ( 3.2A)
None
LLP  A  33 ( 4.6A)
None
LLP  A  33 ( 4.1A)
 0.95A 1vptA-2odoA:
undetectable		 1vptA-2odoA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pgs PUTATIVE
DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE

(Pseudomonas
savastanoi) 		PF01966
(HD) 		5 ILE A 111
GLY A 112
GLY A 117
HIS A 118
ALA A 155
 None
 0.74A 1vptA-2pgsA:
undetectable		 1vptA-2pgsA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2plw RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE

(Plasmodium
falciparum) 		PF01728
(FtsJ) 		5 ILE A  29
GLY A  30
PRO A  33
GLY A  34
ALA A 115
 None
SAM  A 203 (-3.4A)
SAM  A 203 (-3.5A)
SAM  A 203 (-3.6A)
None
 0.72A 1vptA-2plwA:
10.6		 1vptA-2plwA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q4a CLAVAMINATE
SYNTHASE-LIKE
PROTEIN AT3G21360

(Arabidopsis
thaliana) 		PF02668
(TauD) 		5 GLN A  13
ILE A  26
VAL A  64
ALA A  63
LEU A  54
 None
 1.05A 1vptA-2q4aA:
undetectable		 1vptA-2q4aA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qv5 UNCHARACTERIZED
PROTEIN ATU2773

(Agrobacterium
fabrum) 		PF04748
(Polysacc_deac_2) 		5 ILE A 359
GLY A 360
VAL A 389
VAL A 361
ALA A 362
 None
 1.06A 1vptA-2qv5A:
undetectable		 1vptA-2qv5A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd9 ALANINE RACEMASE

(Bacillus
anthracis) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 GLY A 226
GLY A 231
VAL A  39
ALA A  38
LEU A  87
 IN5  A1394 ( 3.2A)
None
IN5  A1394 (-4.6A)
None
EPC  A1395 ( 3.8A)
 0.86A 1vptA-2vd9A:
undetectable		 1vptA-2vd9A:
21.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vp3 VP39

(Vaccinia virus) 		PF01358
(PARP_regulatory) 		5 GLN A  39
ILE A  94
PRO A  71
GLY A  72
HIS A  74
 SAH  A 400 (-3.1A)
None
SAH  A 400 (-3.7A)
SAH  A 400 (-3.5A)
SAH  A 400 (-3.9A)
 0.77A 1vptA-2vp3A:
48.5		 1vptA-2vp3A:
99.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vp3 VP39

(Vaccinia virus) 		PF01358
(PARP_regulatory) 		11 GLN A  39
LEU A  42
TYR A  66
ILE A  67
GLY A  68
PRO A  71
GLY A  72
HIS A  74
VAL A 116
VAL A 139
LEU A 159
 SAH  A 400 (-3.1A)
SAH  A 400 (-4.7A)
SAH  A 400 (-4.6A)
None
SAH  A 400 (-3.4A)
SAH  A 400 (-3.7A)
SAH  A 400 (-3.5A)
SAH  A 400 (-3.9A)
SAH  A 400 (-3.5A)
SAH  A 400 (-4.0A)
None
 0.19A 1vptA-2vp3A:
48.5		 1vptA-2vp3A:
99.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y05 PROSTAGLANDIN
REDUCTASE 1

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		5 LEU A 182
ILE A 161
GLY A 171
VAL A 157
LEU A 287
 None
 1.06A 1vptA-2y05A:
5.5		 1vptA-2y05A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yij PHOSPHOLIPASE
A1-IIGAMMA

(Arabidopsis
thaliana) 		PF01764
(Lipase_3) 		5 LEU A 144
TYR A  50
ILE A  47
VAL A 348
LEU A  39
 None
 0.98A 1vptA-2yijA:
undetectable		 1vptA-2yijA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bzx ESCU

(Escherichia
coli) 		PF01312
(Bac_export_2) 		5 TYR B 324
ILE B 325
VAL B 333
VAL B 282
LEU B 315
 None
 1.05A 1vptA-3bzxB:
undetectable		 1vptA-3bzxB:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c01 SURFACE PRESENTATION
OF ANTIGENS PROTEIN
SPAS
SURFACE PRESENTATION
OF ANTIGENS PROTEIN
SPAS

(Salmonella
enterica;
Salmonella
enterica) 		PF01312
(Bac_export_2)
PF01312
(Bac_export_2) 		5 ILE E 266
VAL E 329
VAL A 256
ALA A 257
LEU E 311
 None
 1.03A 1vptA-3c01E:
undetectable		 1vptA-3c01E:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dlc PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE

(Methanococcus
maripaludis) 		PF08241
(Methyltransf_11) 		5 ILE A  49
GLY A  50
PRO A  53
GLY A  54
VAL A 101
 None
SAM  A 220 (-3.5A)
None
None
SAM  A 220 ( 4.2A)
 1.00A 1vptA-3dlcA:
6.8		 1vptA-3dlcA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmy PROTEIN FDRA

(Escherichia
coli) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		5 LEU A 508
ILE A 196
GLY A 197
VAL A 198
LEU A 209
 None
 0.93A 1vptA-3dmyA:
undetectable		 1vptA-3dmyA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		5 LEU A  38
ILE A  54
GLY A  35
GLY A  30
VAL A  59
 None
 1.00A 1vptA-3dxnA:
undetectable		 1vptA-3dxnA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f9k INTEGRASE

(Human
immunodeficiency
virus 2) 		PF00665
(rve)
PF02022
(Integrase_Zn) 		5 ILE A  73
VAL A 176
VAL A  75
ALA A  76
LEU A 158
 None
 0.76A 1vptA-3f9kA:
undetectable		 1vptA-3f9kA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ggn UNCHARACTERIZED
PROTEIN DR_A0006

(Deinococcus
radiodurans) 		PF03364
(Polyketide_cyc) 		5 ILE A  11
PRO A  96
GLY A  97
VAL A   9
ALA A   8
 None
 1.03A 1vptA-3ggnA:
undetectable		 1vptA-3ggnA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3w PHOSPHOGLUCOSAMINE
MUTASE

(Francisella
tularensis) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 ILE A 236
GLY A 235
GLY A 252
VAL A 175
LEU A 192
 None
 0.96A 1vptA-3i3wA:
undetectable		 1vptA-3i3wA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i8t GALECTIN-4

(Mus musculus) 		PF00337
(Gal-bind_lectin) 		5 ILE A  47
GLY A 130
VAL A  60
VAL A  45
LEU A 148
 None
 0.98A 1vptA-3i8tA:
undetectable		 1vptA-3i8tA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nep MALATE DEHYDROGENASE

(Salinibacter
ruber) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 LEU X 190
GLY X 193
PRO X 201
VAL X 322
LEU X 285
 None
 1.05A 1vptA-3nepX:
undetectable		 1vptA-3nepX:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 397
GLY A 488
VAL A 374
ALA A 373
LEU A 351
 None
None
None
SM5  A   1 (-3.6A)
None
 0.93A 1vptA-3omvA:
undetectable		 1vptA-3omvA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p9x PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE

(Bacillus
halodurans) 		PF00551
(Formyl_trans_N) 		5 ILE A 108
PRO A 117
GLY A 118
VAL A 135
LEU A 177
 None
 1.08A 1vptA-3p9xA:
3.4		 1vptA-3p9xA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qm2 PHOSPHOSERINE
AMINOTRANSFERASE

(Salmonella
enterica) 		PF00266
(Aminotran_5) 		5 GLY A 201
PRO A  11
GLY A  10
VAL A  18
ALA A 245
 None
 0.98A 1vptA-3qm2A:
undetectable		 1vptA-3qm2A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qua PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycolicibacterium
smegmatis) 		PF03641
(Lysine_decarbox) 		5 TYR A  23
ILE A 117
VAL A  40
VAL A  20
ALA A  19
 None
 0.77A 1vptA-3quaA:
undetectable		 1vptA-3quaA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qua PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycolicibacterium
smegmatis) 		PF03641
(Lysine_decarbox) 		5 TYR A  23
ILE A 117
VAL A  40
VAL A  20
LEU A 188
 None
 0.93A 1vptA-3quaA:
undetectable		 1vptA-3quaA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae) 		PF02395
(Peptidase_S6)
PF03212
(Pertactin) 		5 GLN A 211
LEU A 221
ILE A 262
GLY A 261
VAL A  94
 None
 1.01A 1vptA-3syjA:
undetectable		 1vptA-3syjA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uzu RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Burkholderia
pseudomallei) 		PF00398
(RrnaAD) 		5 LEU A 126
ILE A 115
GLY A 116
PRO A 119
LEU A  67
 None
 1.02A 1vptA-3uzuA:
8.0		 1vptA-3uzuA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va6 TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE

(Bacteroides
thetaiotaomicron) 		PF07494
(Reg_prop)
PF07495
(Y_Y_Y) 		5 ILE A 175
GLY A 145
GLY A 106
VAL A 188
LEU A 170
 None
 1.07A 1vptA-3va6A:
undetectable		 1vptA-3va6A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vil BETA-GLUCOSIDASE

(Neotermes
koshunensis) 		PF00232
(Glyco_hydro_1) 		5 ILE A 334
GLY A 333
HIS A 229
VAL A 398
LEU A 386
 None
 1.03A 1vptA-3vilA:
undetectable		 1vptA-3vilA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3viu PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE 2

(Thermus
thermophilus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 LEU A 566
GLY A 625
VAL A 579
ALA A 657
LEU A 574
 None
 1.05A 1vptA-3viuA:
undetectable		 1vptA-3viuA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3t DNA MISMATCH REPAIR
PROTEIN HSM3

(Saccharomyces
cerevisiae) 		no annotation 5 LEU A 415
TYR A 384
GLY A 417
VAL A 430
LEU A 427
 None
 1.06A 1vptA-4a3tA:
undetectable		 1vptA-4a3tA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Aeropyrum
pernix) 		PF01269
(Fibrillarin) 		5 TYR A  83
GLY A  85
GLY A  89
VAL A 155
ALA A 156
 SAM  A 301 (-4.5A)
SAM  A 301 (-3.4A)
None
SAM  A 301 (-4.3A)
SAM  A 301 ( 4.2A)
 0.58A 1vptA-4df3A:
8.4		 1vptA-4df3A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyk AMIDOHYDROLASE

(Pseudomonas
aeruginosa) 		PF01979
(Amidohydro_1) 		5 ILE A 187
GLY A 358
VAL A 143
VAL A 152
ALA A 153
 None
 1.03A 1vptA-4dykA:
undetectable		 1vptA-4dykA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f6t MOLYBDENUM STORAGE
PROTEIN SUBUNIT
ALPHA
MOLYBDENUM STORAGE
PROTEIN SUBUNIT BETA

(Azotobacter
vinelandii;
Azotobacter
vinelandii) 		PF00696
(AA_kinase)
PF00696
(AA_kinase) 		5 GLY B  75
GLY B 172
HIS A 158
ALA B 111
LEU B 118
 None
None
8M0  B 302 (-3.7A)
None
None
 0.83A 1vptA-4f6tB:
undetectable		 1vptA-4f6tB:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f6t MOLYBDENUM STORAGE
PROTEIN SUBUNIT
ALPHA
MOLYBDENUM STORAGE
PROTEIN SUBUNIT BETA

(Azotobacter
vinelandii;
Azotobacter
vinelandii) 		PF00696
(AA_kinase)
PF00696
(AA_kinase) 		5 ILE B  74
GLY B  75
GLY B 172
HIS A 158
LEU B 118
 None
None
None
8M0  B 302 (-3.7A)
None
 0.86A 1vptA-4f6tB:
undetectable		 1vptA-4f6tB:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hao PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE

(Yersinia pestis) 		PF01513
(NAD_kinase) 		5 ILE A  10
GLY A   9
GLY A  61
VAL A  37
ALA A  36
 None
 1.04A 1vptA-4haoA:
undetectable		 1vptA-4haoA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hds ARSB

(Sporomusa ovata) 		PF02277
(DBI_PRT) 		5 LEU B   5
ILE B 155
GLY B 152
VAL B 108
VAL B 151
 None
 1.07A 1vptA-4hdsB:
undetectable		 1vptA-4hdsB:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjl NAPHTHALENE
1,2-DIOXYGENASE
SUBUNIT ALPHA

(Pseudomonas sp.
C18) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		5 LEU A 269
GLY A 311
GLY A 259
ALA A 345
LEU A 182
 None
 0.79A 1vptA-4hjlA:
undetectable		 1vptA-4hjlA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i59 CYCLOHEXYLAMINE
OXIDASE

(Microbacterium
oxydans) 		PF01593
(Amino_oxidase) 		5 ILE A  36
GLY A  43
GLY A  68
VAL A 288
LEU A  50
 None
None
FAD  A 501 (-3.1A)
None
None
 1.07A 1vptA-4i59A:
undetectable		 1vptA-4i59A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iws PA0254

(Pseudomonas
aeruginosa) 		PF01977
(UbiD) 		5 LEU A  81
TYR A 348
GLY A 323
VAL A 391
LEU A 330
 None
 0.86A 1vptA-4iwsA:
undetectable		 1vptA-4iwsA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9v POTASSIUM UPTAKE
PROTEIN TRKA

(Vibrio
parahaemolyticus) 		PF02080
(TrkA_C)
PF02254
(TrkA_N) 		5 ILE A   3
VAL A 362
VAL A  70
ALA A  71
LEU A  15
 None
 0.99A 1vptA-4j9vA:
5.5		 1vptA-4j9vA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9v POTASSIUM UPTAKE
PROTEIN TRKA

(Vibrio
parahaemolyticus) 		PF02080
(TrkA_C)
PF02254
(TrkA_N) 		5 LEU A  58
ILE A   3
VAL A 362
VAL A  70
LEU A  15
 None
 0.93A 1vptA-4j9vA:
5.5		 1vptA-4j9vA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jz7 CARBAMATE KINASE

(Giardia
intestinalis) 		PF00696
(AA_kinase) 		5 GLY A  56
GLY A  13
VAL A 213
VAL A  59
LEU A  78
 None
ANP  A1001 (-3.3A)
None
None
None
 0.93A 1vptA-4jz7A:
undetectable		 1vptA-4jz7A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9d ADENYLOSUCCINATE
SYNTHETASE

(Bacillus
anthracis) 		PF00709
(Adenylsucc_synt) 		5 GLY A 221
GLY A  40
HIS A  41
VAL A 247
VAL A   7
 None
MLI  A 502 (-4.8A)
MLI  A 502 (-4.2A)
None
None
 1.04A 1vptA-4m9dA:
undetectable		 1vptA-4m9dA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ml9 UNCHARACTERIZED
PROTEIN

(Sebaldella
termitidis) 		PF00977
(His_biosynth) 		5 LEU A  30
TYR A 163
ILE A 138
VAL A 149
VAL A 136
 None
 1.00A 1vptA-4ml9A:
undetectable		 1vptA-4ml9A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wr3 ALANINE RACEMASE,
BIOSYNTHETIC

(Escherichia
coli) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 GLY A 211
GLY A 216
VAL A  32
ALA A  31
LEU A  78
 PLP  A1001 (-3.3A)
None
PLP  A1001 ( 4.6A)
None
PLP  A1001 ( 3.9A)
 0.90A 1vptA-4wr3A:
undetectable		 1vptA-4wr3A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xel INORGANIC
PYROPHOSPHATASE

(Pseudomonas
aeruginosa) 		PF00719
(Pyrophosphatase) 		5 ILE A  59
GLY A  67
VAL A 170
ALA A 171
LEU A  12
 None
 1.08A 1vptA-4xelA:
undetectable		 1vptA-4xelA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zmh UNCHARACTERIZED
PROTEIN

(Saccharophagus
degradans) 		PF15979
(Glyco_hydro_115) 		5 ILE A 954
GLY A 965
VAL A 871
ALA A 800
LEU A 865
 None
 0.72A 1vptA-4zmhA:
undetectable		 1vptA-4zmhA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0t RIBONUCLEASE J

(Streptomyces
coelicolor) 		PF00753
(Lactamase_B)
PF07521
(RMMBL) 		5 ILE A 106
GLY A 107
GLY A  85
VAL A 131
ALA A 132
 None
 1.01A 1vptA-5a0tA:
undetectable		 1vptA-5a0tA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e2g BETA-LACTAMASE

(Burkholderia
cenocepacia) 		PF00144
(Beta-lactamase) 		5 ILE A  57
GLY A  58
GLY A 315
ALA A 216
LEU A  64
 None
 1.00A 1vptA-5e2gA:
undetectable		 1vptA-5e2gA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kwn E3 UBIQUITIN-PROTEIN
LIGASE COP1

(Arabidopsis
thaliana) 		PF00400
(WD40) 		5 ILE A 530
GLY A 524
GLY A 482
VAL A 552
ALA A 551
 None
 0.88A 1vptA-5kwnA:
undetectable		 1vptA-5kwnA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m99 ALPHA-AMYLASE

(Thermotoga
petrophila) 		PF00128
(Alpha-amylase) 		5 ILE B  35
VAL B  54
VAL B  69
ALA B  68
LEU B  61
 None
 1.01A 1vptA-5m99B:
undetectable		 1vptA-5m99B:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nag KYNURENINE
3-MONOOXYGENASE

(Pseudomonas
fluorescens) 		PF01494
(FAD_binding_3) 		5 LEU A 334
ILE A  13
GLY A 164
GLY A 310
LEU A 145
 None
FAD  A 501 (-4.6A)
None
FAD  A 501 (-3.4A)
None
 1.09A 1vptA-5nagA:
undetectable		 1vptA-5nagA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oyd CELLULASE, PUTATIVE,
CEL5D

(Cellvibrio
japonicus) 		no annotation 5 ILE A 130
HIS A 323
VAL A 164
ALA A 163
LEU A 153
 None
NBG  A 501 ( 3.7A)
None
None
None
 1.09A 1vptA-5oydA:
undetectable		 1vptA-5oydA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oyd CELLULASE, PUTATIVE,
CEL5D

(Cellvibrio
japonicus) 		no annotation 5 ILE A 166
HIS A 323
VAL A 164
ALA A 163
LEU A 153
 None
NBG  A 501 ( 3.7A)
None
None
None
 0.93A 1vptA-5oydA:
undetectable		 1vptA-5oydA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t1v NS2B-NS3
PROTEASE,NS2B-NS3
PROTEASE

(Zika virus) 		PF00949
(Peptidase_S7)
PF01002
(Flavi_NS2B) 		5 LEU A 141
ILE A 204
GLY A 213
VAL A 160
VAL A 219
 None
 0.95A 1vptA-5t1vA:
undetectable		 1vptA-5t1vA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tf0 GLYCOSYL HYDROLASE
FAMILY 3 N-TERMINAL
DOMAIN PROTEIN

(Bacteroides
intestinalis) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 TYR A 698
ILE A 758
GLY A 759
GLY A 651
VAL A 681
 None
 1.08A 1vptA-5tf0A:
undetectable		 1vptA-5tf0A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thk PUTATIVE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF13561
(adh_short_C2) 		6 ILE A 250
GLY A 188
GLY A 150
VAL A 229
VAL A 187
ALA A 186
 None
 1.22A 1vptA-5thkA:
5.4		 1vptA-5thkA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1c HIV-1 INTEGRASE,
SSO7D CHIMERA

(Sulfolobus
solfataricus;
Human
immunodeficiency
virus 1) 		PF00552
(IN_DBD_C)
PF00665
(rve)
PF02022
(Integrase_Zn) 		5 ILE A  73
VAL A 176
VAL A  75
ALA A  76
LEU A 158
 None
 0.87A 1vptA-5u1cA:
undetectable		 1vptA-5u1cA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u24 PUTATIVE
AMINOTRANSFERASE

(Campylobacter
jejuni) 		PF01041
(DegT_DnrJ_EryC1) 		5 LEU A 237
ILE A  53
GLY A  54
VAL A  55
LEU A  64
 None
 0.96A 1vptA-5u24A:
undetectable		 1vptA-5u24A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ucd NAD(P)-DEPENDENT
BENZALDEHYDE
DEHYDROGENASE

(Pseudomonas
putida) 		PF00171
(Aldedh) 		5 ILE A 381
GLY A 380
VAL A 370
VAL A 377
LEU A 225
 None
 0.98A 1vptA-5ucdA:
undetectable		 1vptA-5ucdA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v5f AT3G11770

(Arabidopsis
thaliana) 		PF01612
(DNA_pol_A_exo1) 		5 LEU A 115
ILE A 132
GLY A 108
VAL A 194
VAL A 107
 None
 0.93A 1vptA-5v5fA:
undetectable		 1vptA-5v5fA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v9x ATP-DEPENDENT DNA
HELICASE

(Mycolicibacterium
smegmatis) 		no annotation 5 ILE A 273
VAL A 373
VAL A 358
ALA A 331
LEU A 350
 None
 1.00A 1vptA-5v9xA:
undetectable		 1vptA-5v9xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6x MRNA CAPPING ENZYME
P5

(Rice dwarf
virus) 		no annotation 6 LEU C 269
TYR C 285
ILE C 286
GLY C 287
PRO C 290
HIS C 293
 None
 0.66A 1vptA-5x6xC:
12.4		 1vptA-5x6xC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
9, MITOCHONDRIAL

(Homo sapiens) 		PF01370
(Epimerase) 		5 ILE J 249
GLY J 248
VAL J  69
VAL J 245
LEU J  65
 None
None
None
None
NDP  J 401 (-4.6A)
 1.09A 1vptA-5xtdJ:
undetectable		 1vptA-5xtdJ:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y81 ACTIN-RELATED
PROTEIN 4

(Saccharomyces
cerevisiae) 		no annotation 5 ILE F  28
GLY F 455
VAL F  17
ALA F  16
LEU F  94
 None
 0.97A 1vptA-5y81F:
undetectable		 1vptA-5y81F:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yeq KETOL-ACID
REDUCTOISOMERASE
(NADP(+))

(Sulfolobus
acidocaldarius) 		no annotation 5 GLY A 101
VAL A 168
VAL A  20
ALA A  21
LEU A  36
 None
 1.00A 1vptA-5yeqA:
undetectable		 1vptA-5yeqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5za2 BETA-LACTAMASE

(Escherichia
coli) 		no annotation 5 ILE A  62
GLY A  63
GLY A 319
ALA A 221
LEU A  69
 None
NXL  A 401 (-3.8A)
EPE  A 405 (-4.0A)
None
None
 1.04A 1vptA-5za2A:
undetectable		 1vptA-5za2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9b PLP-DEPENDENT
L-ARGININE
HYDROXYLASE MPPP

(Streptomyces
wadayamensis) 		no annotation 5 ILE A 353
GLY A 163
VAL A 288
VAL A 312
ALA A 313
 None
 1.01A 1vptA-6c9bA:
2.6		 1vptA-6c9bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG

(Homo sapiens) 		no annotation 5 ILE A 718
VAL A 677
VAL A 716
ALA A 715
LEU A 683
 None
None
None
919  A1101 (-3.5A)
None
 1.03A 1vptA-6cnhA:
undetectable		 1vptA-6cnhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cpy GRMZM2G135359
PSEUDOKINASE

(Zea mays) 		no annotation 5 ILE A 338
GLY A 337
PRO A 492
ALA A 369
LEU A 314
 None
 0.79A 1vptA-6cpyA:
undetectable		 1vptA-6cpyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6epi ZETA_1 TOXIN

(Neisseria
gonorrhoeae) 		no annotation 5 GLN B 266
GLY B 112
GLY B 182
VAL B 161
ALA B 165
 None
SO4  B 502 (-3.3A)
None
None
None
 0.94A 1vptA-6epiB:
undetectable		 1vptA-6epiB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f1y CYTOPLASMIC DYNEIN 1
LIGHT INTERMEDIATE
CHAIN 2

(Homo sapiens) 		no annotation 5 GLN j 150
ILE j 134
VAL j 136
ALA j 137
LEU j  70
 None
 0.70A 1vptA-6f1yj:
undetectable		 1vptA-6f1yj:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fg9 -

(-) 		no annotation 5 LEU A1020
ILE A 884
GLY A 885
VAL A 955
ALA A 931
 None
 0.89A 1vptA-6fg9A:
undetectable		 1vptA-6fg9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fik POLYKETIDE SYNTHASE

(Cercospora
nicotianae) 		no annotation 5 GLN A 989
GLY A1012
VAL A1120
ALA A1036
LEU A1043
 None
 0.84A 1vptA-6fikA:
undetectable		 1vptA-6fikA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
9, MITOCHONDRIAL

(Mus musculus) 		no annotation 5 ILE P 214
GLY P 213
VAL P  34
VAL P 210
LEU P  30
 None
None
None
None
NDP  P 501 ( 4.6A)
 1.00A 1vptA-6g2jP:
undetectable		 1vptA-6g2jP:
undetectable