SIMILAR PATTERNS OF AMINO ACIDS FOR 1VPT_A_SAMA400

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1biu HIV-1 INTEGRASE

(Human
immunodeficiency
virus 1) 		PF00665
(rve) 		5 ILE A  73
VAL A 176
VAL A  75
ALA A  76
LEU A 158
 None
 0.79A 1vptA-1biuA:
undetectable		 1vptA-1biuA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bs9 ACETYL XYLAN
ESTERASE

(Talaromyces
purpureogenus) 		PF01083
(Cutinase) 		5 GLN A 188
GLY A  92
HIS A 187
VAL A  68
ALA A  45
 None
 1.02A 1vptA-1bs9A:
undetectable		 1vptA-1bs9A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ea9 CYCLOMALTODEXTRINASE

(Bacillus sp.
(in: Bacteria)) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		5 ILE C 136
VAL C 174
VAL C 189
ALA C 188
LEU C 181
 None
 1.01A 1vptA-1ea9C:
undetectable		 1vptA-1ea9C:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ex4 INTEGRASE

(Human
immunodeficiency
virus 1) 		PF00552
(IN_DBD_C)
PF00665
(rve) 		5 ILE A  73
VAL A 176
VAL A  75
ALA A  76
LEU A 158
 None
 0.77A 1vptA-1ex4A:
undetectable		 1vptA-1ex4A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g5g FUSION PROTEIN

(Avian
avulavirus 1) 		PF00523
(Fusion_gly) 		5 LEU A 345
TYR A 302
VAL A 319
VAL A 323
LEU A 363
 None
 0.98A 1vptA-1g5gA:
undetectable		 1vptA-1g5gA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k6y INTEGRASE

(Human
immunodeficiency
virus 1) 		PF00665
(rve)
PF02022
(Integrase_Zn) 		5 ILE A  73
VAL A 176
VAL A  75
ALA A  76
LEU A 158
 None
 0.76A 1vptA-1k6yA:
undetectable		 1vptA-1k6yA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m54 CYSTATHIONINE
BETA-SYNTHASE

(Homo sapiens) 		PF00291
(PALP) 		5 LEU A 338
ILE A 373
GLY A 348
ALA A 357
LEU A 251
 None
 1.02A 1vptA-1m54A:
1.9		 1vptA-1m54A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m9u EARTHWORM
FIBRINOLYTIC ENZYME

(Eisenia fetida) 		PF00089
(Trypsin) 		5 ILE A 181
GLY A 211
GLY A 196
VAL A 162
VAL A 210
 None
 1.06A 1vptA-1m9uA:
undetectable		 1vptA-1m9uA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mv0 MYC
BOX-DEPENDENT-INTERA
CTING PROTEIN 1

(Homo sapiens) 		PF14604
(SH3_9) 		5 ILE B 439
GLY B 454
PRO B 474
VAL B 455
LEU B 466
 None
 1.08A 1vptA-1mv0B:
undetectable		 1vptA-1mv0B:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mzj BETA-KETOACYLSYNTHAS
E III

(Streptomyces
sp. R1128) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 ILE A 316
GLY A 326
PRO A 185
GLY A 184
VAL A 233
 None
 1.05A 1vptA-1mzjA:
undetectable		 1vptA-1mzjA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rcq CATABOLIC ALANINE
RACEMASE DADX

(Pseudomonas
aeruginosa) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 GLY A 210
GLY A 215
VAL A  31
ALA A  30
LEU A  78
 PLP  A 358 (-3.3A)
None
PLP  A 358 (-4.4A)
None
PLP  A 358 ( 4.2A)
 0.96A 1vptA-1rcqA:
undetectable		 1vptA-1rcqA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u60 PROBABLE GLUTAMINASE
YBAS

(Escherichia
coli) 		PF04960
(Glutaminase) 		5 LEU A  64
ILE A 203
GLY A 265
VAL A  52
LEU A 220
 None
EDO  A1217 ( 3.8A)
None
None
None
 0.78A 1vptA-1u60A:
undetectable		 1vptA-1u60A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vzo RIBOSOMAL PROTEIN S6
KINASE ALPHA 5

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A 312
GLY A 303
VAL A 162
ALA A 235
LEU A 241
 None
None
None
BME  A1304 (-3.3A)
None
 0.90A 1vptA-1vzoA:
undetectable		 1vptA-1vzoA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa5 IMPORTIN ALPHA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00514
(Arm)
PF01749
(IBB)
PF16186
(Arm_3) 		5 LEU B 346
ILE B 326
GLY B 341
VAL B 295
ALA B 319
 None
 1.01A 1vptA-1wa5B:
undetectable		 1vptA-1wa5B:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wue MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Enterococcus
faecalis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLN A1304
LEU A1301
ILE A1036
GLY A1347
LEU A1076
 None
 1.05A 1vptA-1wueA:
undetectable		 1vptA-1wueA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xg5 ARPG836

(Homo sapiens) 		PF00106
(adh_short) 		5 ILE A  95
GLY A  99
VAL A 236
ALA A  25
LEU A  31
 None
NAP  A1301 (-3.6A)
None
None
None
 0.91A 1vptA-1xg5A:
5.4		 1vptA-1xg5A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yul PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF01467
(CTP_transf_like) 		5 LEU A  37
ILE A   5
GLY A   6
GLY A   9
ALA A  27
 None
 1.01A 1vptA-1yulA:
2.4		 1vptA-1yulA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bg5 PHOSPHOENOLPYRUVATE-
PROTEIN KINASE

(Caldanaerobacter
subterraneus) 		PF02896
(PEP-utilizers_C) 		5 LEU A 406
TYR A 390
ILE A 428
GLY A 427
VAL A 446
 None
 0.96A 1vptA-2bg5A:
undetectable		 1vptA-2bg5A:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c6r DNA-BINDING STRESS
RESPONSE PROTEIN,
DPS FAMILY

(Deinococcus
radiodurans) 		PF00210
(Ferritin) 		5 ILE A 151
GLY A 148
VAL A 172
VAL A 147
LEU A  59
 None
 0.99A 1vptA-2c6rA:
undetectable		 1vptA-2c6rA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1q LUCIFERIN
4-MONOOXYGENASE

(Luciola
cruciata) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 ILE A 351
GLY A 343
GLY A 317
VAL A 394
LEU A 399
 None
None
AMP  A1001 ( 4.3A)
None
None
 0.92A 1vptA-2d1qA:
undetectable		 1vptA-2d1qA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e9y CARBAMATE KINASE

(Aeropyrum
pernix) 		PF00696
(AA_kinase) 		5 GLY A  56
GLY A  13
VAL A 213
VAL A  59
LEU A  78
 None
 1.02A 1vptA-2e9yA:
2.5		 1vptA-2e9yA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gdq YITF

(Bacillus
subtilis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 TYR A 127
ILE A 158
VAL A 147
VAL A 160
LEU A 177
 None
 0.83A 1vptA-2gdqA:
undetectable		 1vptA-2gdqA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuy GLYCOSYLTRANSFERASE

(Streptomyces
viridochromogenes) 		PF00534
(Glycos_transf_1) 		5 GLY A 114
VAL A 339
VAL A  16
ALA A  17
LEU A  53
 None
 0.95A 1vptA-2iuyA:
2.5		 1vptA-2iuyA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jh9 VP4 CORE PROTEIN

(Bluetongue
virus) 		PF05059
(Orbi_VP4) 		6 LEU A 179
TYR A 195
ILE A 196
GLY A 197
VAL A 242
VAL A 266
 None
 0.57A 1vptA-2jh9A:
14.5		 1vptA-2jh9A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odo ALANINE RACEMASE

(Pseudomonas
fluorescens) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 GLY A 210
GLY A 215
VAL A  31
ALA A  30
LEU A  78
 LLP  A  33 ( 3.2A)
None
LLP  A  33 ( 4.6A)
None
LLP  A  33 ( 4.1A)
 0.95A 1vptA-2odoA:
undetectable		 1vptA-2odoA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pgs PUTATIVE
DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE

(Pseudomonas
savastanoi) 		PF01966
(HD) 		5 ILE A 111
GLY A 112
GLY A 117
HIS A 118
ALA A 155
 None
 0.74A 1vptA-2pgsA:
undetectable		 1vptA-2pgsA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2plw RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE

(Plasmodium
falciparum) 		PF01728
(FtsJ) 		5 ILE A  29
GLY A  30
PRO A  33
GLY A  34
ALA A 115
 None
SAM  A 203 (-3.4A)
SAM  A 203 (-3.5A)
SAM  A 203 (-3.6A)
None
 0.72A 1vptA-2plwA:
10.6		 1vptA-2plwA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q4a CLAVAMINATE
SYNTHASE-LIKE
PROTEIN AT3G21360

(Arabidopsis
thaliana) 		PF02668
(TauD) 		5 GLN A  13
ILE A  26
VAL A  64
ALA A  63
LEU A  54
 None
 1.05A 1vptA-2q4aA:
undetectable		 1vptA-2q4aA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qv5 UNCHARACTERIZED
PROTEIN ATU2773

(Agrobacterium
fabrum) 		PF04748
(Polysacc_deac_2) 		5 ILE A 359
GLY A 360
VAL A 389
VAL A 361
ALA A 362
 None
 1.06A 1vptA-2qv5A:
undetectable		 1vptA-2qv5A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd9 ALANINE RACEMASE

(Bacillus
anthracis) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 GLY A 226
GLY A 231
VAL A  39
ALA A  38
LEU A  87
 IN5  A1394 ( 3.2A)
None
IN5  A1394 (-4.6A)
None
EPC  A1395 ( 3.8A)
 0.86A 1vptA-2vd9A:
undetectable		 1vptA-2vd9A:
21.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vp3 VP39

(Vaccinia virus) 		PF01358
(PARP_regulatory) 		5 GLN A  39
ILE A  94
PRO A  71
GLY A  72
HIS A  74
 SAH  A 400 (-3.1A)
None
SAH  A 400 (-3.7A)
SAH  A 400 (-3.5A)
SAH  A 400 (-3.9A)
 0.77A 1vptA-2vp3A:
48.5		 1vptA-2vp3A:
99.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vp3 VP39

(Vaccinia virus) 		PF01358
(PARP_regulatory) 		11 GLN A  39
LEU A  42
TYR A  66
ILE A  67
GLY A  68
PRO A  71
GLY A  72
HIS A  74
VAL A 116
VAL A 139
LEU A 159
 SAH  A 400 (-3.1A)
SAH  A 400 (-4.7A)
SAH  A 400 (-4.6A)
None
SAH  A 400 (-3.4A)
SAH  A 400 (-3.7A)
SAH  A 400 (-3.5A)
SAH  A 400 (-3.9A)
SAH  A 400 (-3.5A)
SAH  A 400 (-4.0A)
None
 0.19A 1vptA-2vp3A:
48.5		 1vptA-2vp3A:
99.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y05 PROSTAGLANDIN
REDUCTASE 1

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		5 LEU A 182
ILE A 161
GLY A 171
VAL A 157
LEU A 287
 None
 1.06A 1vptA-2y05A:
5.5		 1vptA-2y05A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yij PHOSPHOLIPASE
A1-IIGAMMA

(Arabidopsis
thaliana) 		PF01764
(Lipase_3) 		5 LEU A 144
TYR A  50
ILE A  47
VAL A 348
LEU A  39
 None
 0.98A 1vptA-2yijA:
undetectable		 1vptA-2yijA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bzx ESCU

(Escherichia
coli) 		PF01312
(Bac_export_2) 		5 TYR B 324
ILE B 325
VAL B 333
VAL B 282
LEU B 315
 None
 1.05A 1vptA-3bzxB:
undetectable		 1vptA-3bzxB:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c01 SURFACE PRESENTATION
OF ANTIGENS PROTEIN
SPAS
SURFACE PRESENTATION
OF ANTIGENS PROTEIN
SPAS

(Salmonella
enterica;
Salmonella
enterica) 		PF01312
(Bac_export_2)
PF01312
(Bac_export_2) 		5 ILE E 266
VAL E 329
VAL A 256
ALA A 257
LEU E 311
 None
 1.03A 1vptA-3c01E:
undetectable		 1vptA-3c01E:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dlc PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE

(Methanococcus
maripaludis) 		PF08241
(Methyltransf_11) 		5 ILE A  49
GLY A  50
PRO A  53
GLY A  54
VAL A 101
 None
SAM  A 220 (-3.5A)
None
None
SAM  A 220 ( 4.2A)
 1.00A 1vptA-3dlcA:
6.8		 1vptA-3dlcA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmy PROTEIN FDRA

(Escherichia
coli) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		5 LEU A 508
ILE A 196
GLY A 197
VAL A 198
LEU A 209
 None
 0.93A 1vptA-3dmyA:
undetectable		 1vptA-3dmyA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		5 LEU A  38
ILE A  54
GLY A  35
GLY A  30
VAL A  59
 None
 1.00A 1vptA-3dxnA:
undetectable		 1vptA-3dxnA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f9k INTEGRASE

(Human
immunodeficiency
virus 2) 		PF00665
(rve)
PF02022
(Integrase_Zn) 		5 ILE A  73
VAL A 176
VAL A  75
ALA A  76
LEU A 158
 None
 0.76A 1vptA-3f9kA:
undetectable		 1vptA-3f9kA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ggn UNCHARACTERIZED
PROTEIN DR_A0006

(Deinococcus
radiodurans) 		PF03364
(Polyketide_cyc) 		5 ILE A  11
PRO A  96
GLY A  97
VAL A   9
ALA A   8
 None
 1.03A 1vptA-3ggnA:
undetectable		 1vptA-3ggnA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3w PHOSPHOGLUCOSAMINE
MUTASE

(Francisella
tularensis) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 ILE A 236
GLY A 235
GLY A 252
VAL A 175
LEU A 192
 None
 0.96A 1vptA-3i3wA:
undetectable		 1vptA-3i3wA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i8t GALECTIN-4

(Mus musculus) 		PF00337
(Gal-bind_lectin) 		5 ILE A  47
GLY A 130
VAL A  60
VAL A  45
LEU A 148
 None
 0.98A 1vptA-3i8tA:
undetectable		 1vptA-3i8tA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nep MALATE DEHYDROGENASE

(Salinibacter
ruber) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 LEU X 190
GLY X 193
PRO X 201
VAL X 322
LEU X 285
 None
 1.05A 1vptA-3nepX:
undetectable		 1vptA-3nepX:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 397
GLY A 488
VAL A 374
ALA A 373
LEU A 351
 None
None
None
SM5  A   1 (-3.6A)
None
 0.93A 1vptA-3omvA:
undetectable		 1vptA-3omvA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p9x PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE

(Bacillus
halodurans) 		PF00551
(Formyl_trans_N) 		5 ILE A 108
PRO A 117
GLY A 118
VAL A 135
LEU A 177
 None
 1.08A 1vptA-3p9xA:
3.4		 1vptA-3p9xA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qm2 PHOSPHOSERINE
AMINOTRANSFERASE

(Salmonella
enterica) 		PF00266
(Aminotran_5) 		5 GLY A 201
PRO A  11
GLY A  10
VAL A  18
ALA A 245
 None
 0.98A 1vptA-3qm2A:
undetectable		 1vptA-3qm2A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qua PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycolicibacterium
smegmatis) 		PF03641
(Lysine_decarbox) 		5 TYR A  23
ILE A 117
VAL A  40
VAL A  20
ALA A  19
 None
 0.77A 1vptA-3quaA:
undetectable		 1vptA-3quaA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qua PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycolicibacterium
smegmatis) 		PF03641
(Lysine_decarbox) 		5 TYR A  23
ILE A 117
VAL A  40
VAL A  20
LEU A 188
 None
 0.93A 1vptA-3quaA:
undetectable		 1vptA-3quaA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae) 		PF02395
(Peptidase_S6)
PF03212
(Pertactin) 		5 GLN A 211
LEU A 221
ILE A 262
GLY A 261
VAL A  94
 None
 1.01A 1vptA-3syjA:
undetectable		 1vptA-3syjA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uzu RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Burkholderia
pseudomallei) 		PF00398
(RrnaAD) 		5 LEU A 126
ILE A 115
GLY A 116
PRO A 119
LEU A  67
 None
 1.02A 1vptA-3uzuA:
8.0		 1vptA-3uzuA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va6 TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE

(Bacteroides
thetaiotaomicron) 		PF07494
(Reg_prop)
PF07495
(Y_Y_Y) 		5 ILE A 175
GLY A 145
GLY A 106
VAL A 188
LEU A 170
 None
 1.07A 1vptA-3va6A:
undetectable		 1vptA-3va6A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vil BETA-GLUCOSIDASE

(Neotermes
koshunensis) 		PF00232
(Glyco_hydro_1) 		5 ILE A 334
GLY A 333
HIS A 229
VAL A 398
LEU A 386
 None
 1.03A 1vptA-3vilA:
undetectable		 1vptA-3vilA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3viu PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE 2

(Thermus
thermophilus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 LEU A 566
GLY A 625
VAL A 579
ALA A 657
LEU A 574
 None
 1.05A 1vptA-3viuA:
undetectable		 1vptA-3viuA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3t DNA MISMATCH REPAIR
PROTEIN HSM3

(Saccharomyces
cerevisiae) 		no annotation 5 LEU A 415
TYR A 384
GLY A 417
VAL A 430
LEU A 427
 None
 1.06A 1vptA-4a3tA:
undetectable		 1vptA-4a3tA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Aeropyrum
pernix) 		PF01269
(Fibrillarin) 		5 TYR A  83
GLY A  85
GLY A  89
VAL A 155
ALA A 156
 SAM  A 301 (-4.5A)
SAM  A 301 (-3.4A)
None
SAM  A 301 (-4.3A)
SAM  A 301 ( 4.2A)
 0.58A 1vptA-4df3A:
8.4		 1vptA-4df3A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyk AMIDOHYDROLASE

(Pseudomonas
aeruginosa) 		PF01979
(Amidohydro_1) 		5 ILE A 187
GLY A 358
VAL A 143
VAL A 152
ALA A 153
 None
 1.03A 1vptA-4dykA:
undetectable		 1vptA-4dykA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f6t MOLYBDENUM STORAGE
PROTEIN SUBUNIT
ALPHA
MOLYBDENUM STORAGE
PROTEIN SUBUNIT BETA

(Azotobacter
vinelandii;
Azotobacter
vinelandii) 		PF00696
(AA_kinase)
PF00696
(AA_kinase) 		5 GLY B  75
GLY B 172
HIS A 158
ALA B 111
LEU B 118
 None
None
8M0  B 302 (-3.7A)
None
None
 0.83A 1vptA-4f6tB:
undetectable		 1vptA-4f6tB:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f6t MOLYBDENUM STORAGE
PROTEIN SUBUNIT
ALPHA
MOLYBDENUM STORAGE
PROTEIN SUBUNIT BETA

(Azotobacter
vinelandii;
Azotobacter
vinelandii) 		PF00696
(AA_kinase)
PF00696
(AA_kinase) 		5 ILE B  74
GLY B  75
GLY B 172
HIS A 158
LEU B 118
 None
None
None
8M0  B 302 (-3.7A)
None
 0.86A 1vptA-4f6tB:
undetectable		 1vptA-4f6tB:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hao PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE

(Yersinia pestis) 		PF01513
(NAD_kinase) 		5 ILE A  10
GLY A   9
GLY A  61
VAL A  37
ALA A  36
 None
 1.04A 1vptA-4haoA:
undetectable		 1vptA-4haoA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hds ARSB

(Sporomusa ovata) 		PF02277
(DBI_PRT) 		5 LEU B   5
ILE B 155
GLY B 152
VAL B 108
VAL B 151
 None
 1.07A 1vptA-4hdsB:
undetectable		 1vptA-4hdsB:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjl NAPHTHALENE
1,2-DIOXYGENASE
SUBUNIT ALPHA

(Pseudomonas sp.
C18) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		5 LEU A 269
GLY A 311
GLY A 259
ALA A 345
LEU A 182
 None
 0.79A 1vptA-4hjlA:
undetectable		 1vptA-4hjlA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i59 CYCLOHEXYLAMINE
OXIDASE

(Microbacterium
oxydans) 		PF01593
(Amino_oxidase) 		5 ILE A  36
GLY A  43
GLY A  68
VAL A 288
LEU A  50
 None
None
FAD  A 501 (-3.1A)
None
None
 1.07A 1vptA-4i59A:
undetectable		 1vptA-4i59A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iws PA0254

(Pseudomonas
aeruginosa) 		PF01977
(UbiD) 		5 LEU A  81
TYR A 348
GLY A 323
VAL A 391
LEU A 330
 None
 0.86A 1vptA-4iwsA:
undetectable		 1vptA-4iwsA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9v POTASSIUM UPTAKE
PROTEIN TRKA

(Vibrio
parahaemolyticus) 		PF02080
(TrkA_C)
PF02254
(TrkA_N) 		5 ILE A   3
VAL A 362
VAL A  70
ALA A  71
LEU A  15
 None
 0.99A 1vptA-4j9vA:
5.5		 1vptA-4j9vA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9v POTASSIUM UPTAKE
PROTEIN TRKA

(Vibrio
parahaemolyticus) 		PF02080
(TrkA_C)
PF02254
(TrkA_N) 		5 LEU A  58
ILE A   3
VAL A 362
VAL A  70
LEU A  15
 None
 0.93A 1vptA-4j9vA:
5.5		 1vptA-4j9vA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jz7 CARBAMATE KINASE

(Giardia
intestinalis) 		PF00696
(AA_kinase) 		5 GLY A  56
GLY A  13
VAL A 213
VAL A  59
LEU A  78
 None
ANP  A1001 (-3.3A)
None
None
None
 0.93A 1vptA-4jz7A:
undetectable		 1vptA-4jz7A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9d ADENYLOSUCCINATE
SYNTHETASE

(Bacillus
anthracis) 		PF00709
(Adenylsucc_synt) 		5 GLY A 221
GLY A  40
HIS A  41
VAL A 247
VAL A   7
 None
MLI  A 502 (-4.8A)
MLI  A 502 (-4.2A)
None
None
 1.04A 1vptA-4m9dA:
undetectable		 1vptA-4m9dA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ml9 UNCHARACTERIZED
PROTEIN

(Sebaldella
termitidis) 		PF00977
(His_biosynth) 		5 LEU A  30
TYR A 163
ILE A 138
VAL A 149
VAL A 136
 None
 1.00A 1vptA-4ml9A:
undetectable		 1vptA-4ml9A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wr3 ALANINE RACEMASE,
BIOSYNTHETIC

(Escherichia
coli) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 GLY A 211
GLY A 216
VAL A  32
ALA A  31
LEU A  78
 PLP  A1001 (-3.3A)
None
PLP  A1001 ( 4.6A)
None
PLP  A1001 ( 3.9A)
 0.90A 1vptA-4wr3A:
undetectable		 1vptA-4wr3A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xel INORGANIC
PYROPHOSPHATASE

(Pseudomonas
aeruginosa) 		PF00719
(Pyrophosphatase) 		5 ILE A  59
GLY A  67
VAL A 170
ALA A 171
LEU A  12
 None
 1.08A 1vptA-4xelA:
undetectable		 1vptA-4xelA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zmh UNCHARACTERIZED
PROTEIN

(Saccharophagus
degradans) 		PF15979
(Glyco_hydro_115) 		5 ILE A 954
GLY A 965
VAL A 871
ALA A 800
LEU A 865
 None
 0.72A 1vptA-4zmhA:
undetectable		 1vptA-4zmhA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0t RIBONUCLEASE J

(Streptomyces
coelicolor) 		PF00753
(Lactamase_B)
PF07521
(RMMBL) 		5 ILE A 106
GLY A 107
GLY A  85
VAL A 131
ALA A 132
 None
 1.01A 1vptA-5a0tA:
undetectable		 1vptA-5a0tA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e2g BETA-LACTAMASE

(Burkholderia
cenocepacia) 		PF00144
(Beta-lactamase) 		5 ILE A  57
GLY A  58
GLY A 315
ALA A 216
LEU A  64
 None
 1.00A 1vptA-5e2gA:
undetectable		 1vptA-5e2gA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kwn E3 UBIQUITIN-PROTEIN
LIGASE COP1

(Arabidopsis
thaliana) 		PF00400
(WD40) 		5 ILE A 530
GLY A 524
GLY A 482
VAL A 552
ALA A 551
 None
 0.88A 1vptA-5kwnA:
undetectable		 1vptA-5kwnA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m99 ALPHA-AMYLASE

(Thermotoga
petrophila) 		PF00128
(Alpha-amylase) 		5 ILE B  35
VAL B  54
VAL B  69
ALA B  68
LEU B  61
 None
 1.01A 1vptA-5m99B:
undetectable		 1vptA-5m99B:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nag KYNURENINE
3-MONOOXYGENASE

(Pseudomonas
fluorescens) 		PF01494
(FAD_binding_3) 		5 LEU A 334
ILE A  13
GLY A 164
GLY A 310
LEU A 145
 None
FAD  A 501 (-4.6A)
None
FAD  A 501 (-3.4A)
None
 1.09A 1vptA-5nagA:
undetectable		 1vptA-5nagA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oyd CELLULASE, PUTATIVE,
CEL5D

(Cellvibrio
japonicus) 		no annotation 5 ILE A 130
HIS A 323
VAL A 164
ALA A 163
LEU A 153
 None
NBG  A 501 ( 3.7A)
None
None
None
 1.09A 1vptA-5oydA:
undetectable		 1vptA-5oydA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oyd CELLULASE, PUTATIVE,
CEL5D

(Cellvibrio
japonicus) 		no annotation 5 ILE A 166
HIS A 323
VAL A 164
ALA A 163
LEU A 153
 None
NBG  A 501 ( 3.7A)
None
None
None
 0.93A 1vptA-5oydA:
undetectable		 1vptA-5oydA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t1v NS2B-NS3
PROTEASE,NS2B-NS3
PROTEASE

(Zika virus) 		PF00949
(Peptidase_S7)
PF01002
(Flavi_NS2B) 		5 LEU A 141
ILE A 204
GLY A 213
VAL A 160
VAL A 219
 None
 0.95A 1vptA-5t1vA:
undetectable		 1vptA-5t1vA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tf0 GLYCOSYL HYDROLASE
FAMILY 3 N-TERMINAL
DOMAIN PROTEIN

(Bacteroides
intestinalis) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 TYR A 698
ILE A 758
GLY A 759
GLY A 651
VAL A 681
 None
 1.08A 1vptA-5tf0A:
undetectable		 1vptA-5tf0A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thk PUTATIVE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF13561
(adh_short_C2) 		6 ILE A 250
GLY A 188
GLY A 150
VAL A 229
VAL A 187
ALA A 186
 None
 1.22A 1vptA-5thkA:
5.4		 1vptA-5thkA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1c HIV-1 INTEGRASE,
SSO7D CHIMERA

(Sulfolobus
solfataricus;
Human
immunodeficiency
virus 1) 		PF00552
(IN_DBD_C)
PF00665
(rve)
PF02022
(Integrase_Zn) 		5 ILE A  73
VAL A 176
VAL A  75
ALA A  76
LEU A 158
 None
 0.87A 1vptA-5u1cA:
undetectable		 1vptA-5u1cA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u24 PUTATIVE
AMINOTRANSFERASE

(Campylobacter
jejuni) 		PF01041
(DegT_DnrJ_EryC1) 		5 LEU A 237
ILE A  53
GLY A  54
VAL A  55
LEU A  64
 None
 0.96A 1vptA-5u24A:
undetectable		 1vptA-5u24A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ucd NAD(P)-DEPENDENT
BENZALDEHYDE
DEHYDROGENASE

(Pseudomonas
putida) 		PF00171
(Aldedh) 		5 ILE A 381
GLY A 380
VAL A 370
VAL A 377
LEU A 225
 None
 0.98A 1vptA-5ucdA:
undetectable		 1vptA-5ucdA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v5f AT3G11770

(Arabidopsis
thaliana) 		PF01612
(DNA_pol_A_exo1) 		5 LEU A 115
ILE A 132
GLY A 108
VAL A 194
VAL A 107
 None
 0.93A 1vptA-5v5fA:
undetectable		 1vptA-5v5fA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v9x ATP-DEPENDENT DNA
HELICASE

(Mycolicibacterium
smegmatis) 		no annotation 5 ILE A 273
VAL A 373
VAL A 358
ALA A 331
LEU A 350
 None
 1.00A 1vptA-5v9xA:
undetectable		 1vptA-5v9xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6x MRNA CAPPING ENZYME
P5

(Rice dwarf
virus) 		no annotation 6 LEU C 269
TYR C 285
ILE C 286
GLY C 287
PRO C 290
HIS C 293
 None
 0.66A 1vptA-5x6xC:
12.4		 1vptA-5x6xC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
9, MITOCHONDRIAL

(Homo sapiens) 		PF01370
(Epimerase) 		5 ILE J 249
GLY J 248
VAL J  69
VAL J 245
LEU J  65
 None
None
None
None
NDP  J 401 (-4.6A)
 1.09A 1vptA-5xtdJ:
undetectable		 1vptA-5xtdJ:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y81 ACTIN-RELATED
PROTEIN 4

(Saccharomyces
cerevisiae) 		no annotation 5 ILE F  28
GLY F 455
VAL F  17
ALA F  16
LEU F  94
 None
 0.97A 1vptA-5y81F:
undetectable		 1vptA-5y81F:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yeq KETOL-ACID
REDUCTOISOMERASE
(NADP(+))

(Sulfolobus
acidocaldarius) 		no annotation 5 GLY A 101
VAL A 168
VAL A  20
ALA A  21
LEU A  36
 None
 1.00A 1vptA-5yeqA:
undetectable		 1vptA-5yeqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5za2 BETA-LACTAMASE

(Escherichia
coli) 		no annotation 5 ILE A  62
GLY A  63
GLY A 319
ALA A 221
LEU A  69
 None
NXL  A 401 (-3.8A)
EPE  A 405 (-4.0A)
None
None
 1.04A 1vptA-5za2A:
undetectable		 1vptA-5za2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9b PLP-DEPENDENT
L-ARGININE
HYDROXYLASE MPPP

(Streptomyces
wadayamensis) 		no annotation 5 ILE A 353
GLY A 163
VAL A 288
VAL A 312
ALA A 313
 None
 1.01A 1vptA-6c9bA:
2.6		 1vptA-6c9bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG

(Homo sapiens) 		no annotation 5 ILE A 718
VAL A 677
VAL A 716
ALA A 715
LEU A 683
 None
None
None
919  A1101 (-3.5A)
None
 1.03A 1vptA-6cnhA:
undetectable		 1vptA-6cnhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cpy GRMZM2G135359
PSEUDOKINASE

(Zea mays) 		no annotation 5 ILE A 338
GLY A 337
PRO A 492
ALA A 369
LEU A 314
 None
 0.79A 1vptA-6cpyA:
undetectable		 1vptA-6cpyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6epi ZETA_1 TOXIN

(Neisseria
gonorrhoeae) 		no annotation 5 GLN B 266
GLY B 112
GLY B 182
VAL B 161
ALA B 165
 None
SO4  B 502 (-3.3A)
None
None
None
 0.94A 1vptA-6epiB:
undetectable		 1vptA-6epiB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f1y CYTOPLASMIC DYNEIN 1
LIGHT INTERMEDIATE
CHAIN 2

(Homo sapiens) 		no annotation 5 GLN j 150
ILE j 134
VAL j 136
ALA j 137
LEU j  70
 None
 0.70A 1vptA-6f1yj:
undetectable		 1vptA-6f1yj:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fg9 -

(-) 		no annotation 5 LEU A1020
ILE A 884
GLY A 885
VAL A 955
ALA A 931
 None
 0.89A 1vptA-6fg9A:
undetectable		 1vptA-6fg9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fik POLYKETIDE SYNTHASE

(Cercospora
nicotianae) 		no annotation 5 GLN A 989
GLY A1012
VAL A1120
ALA A1036
LEU A1043
 None
 0.84A 1vptA-6fikA:
undetectable		 1vptA-6fikA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
9, MITOCHONDRIAL

(Mus musculus) 		no annotation 5 ILE P 214
GLY P 213
VAL P  34
VAL P 210
LEU P  30
 None
None
None
None
NDP  P 501 ( 4.6A)
 1.00A 1vptA-6g2jP:
undetectable		 1vptA-6g2jP:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ddg SULFITE REDUCTASE
(NADPH) FLAVOPROTEIN
ALPHA-COMPONENT

(Escherichia
coli) 		PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1) 		3 ASP A 362
ARG A 365
ASP A 411
 None
 0.92A 1vptA-1ddgA:
3.7		 1vptA-1ddgA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gsq GLUTATHIONE
S-TRANSFERASE

(Todarodes
pacificus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		3 ASP A  77
ARG A  72
ASP A  88
 None
 0.83A 1vptA-1gsqA:
undetectable		 1vptA-1gsqA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ism BONE MARROW STROMAL
CELL ANTIGEN 1

(Homo sapiens) 		PF02267
(Rib_hydrolayse) 		3 ASP A  99
ARG A 104
ASP A  89
 None
 0.92A 1vptA-1ismA:
undetectable		 1vptA-1ismA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k72 ENDOGLUCANASE 9G

([Clostridium]
cellulolyticum) 		PF00759
(Glyco_hydro_9)
PF00942
(CBM_3) 		3 ASP A 124
ARG A 375
ASP A  55
 None
CBI  A 777 (-2.5A)
None
 0.94A 1vptA-1k72A:
undetectable		 1vptA-1k72A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ks8 ENDO-B-1,4-GLUCANASE

(Nasutitermes
takasagoensis) 		PF00759
(Glyco_hydro_9) 		3 ASP A 123
ARG A 361
ASP A  54
 None
SO4  A 450 (-2.9A)
None
 0.97A 1vptA-1ks8A:
undetectable		 1vptA-1ks8A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpb LIPASE

(Homo sapiens) 		PF00151
(Lipase)
PF01477
(PLAT) 		3 ASP B 257
ARG B 265
ASP B 249
 BOG  B 452 ( 3.5A)
BOG  B 452 (-2.4A)
BOG  B 452 (-2.8A)
 0.87A 1vptA-1lpbB:
undetectable		 1vptA-1lpbB:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Wolinella
succinogenes) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		3 ASP A 302
ARG A 306
ASP A  78
 None
 0.87A 1vptA-1qlbA:
undetectable		 1vptA-1qlbA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qxo CHORISMATE SYNTHASE

(Streptococcus
pneumoniae) 		PF01264
(Chorismate_synt) 		3 ASP A 123
ARG A 125
ASP A 112
 None
 0.95A 1vptA-1qxoA:
undetectable		 1vptA-1qxoA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uay TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00106
(adh_short) 		3 ASP A  33
ARG A  35
ASP A  47
 ADN  A1001 (-2.9A)
ADN  A1001 (-3.7A)
ADN  A1001 (-2.9A)
 0.95A 1vptA-1uayA:
4.7		 1vptA-1uayA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4g GLUTAMATE--CYSTEINE
LIGASE

(Escherichia
coli) 		PF04262
(Glu_cys_ligase) 		3 ASP A 412
ARG A 415
ASP A   4
 None
 0.74A 1vptA-1v4gA:
undetectable		 1vptA-1v4gA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w52 PANCREATIC LIPASE
RELATED PROTEIN 2

(Equus caballus) 		PF00151
(Lipase)
PF01477
(PLAT) 		3 ASP X 107
ARG X  38
ASP X  85
 None
 0.92A 1vptA-1w52X:
undetectable		 1vptA-1w52X:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfj CONSERVED
HYPOTHETICAL PROTEIN

(Caulobacter
vibrioides) 		PF02578
(Cu-oxidase_4) 		3 ASP A 139
ARG A 135
ASP A 185
 None
 0.97A 1vptA-1xfjA:
undetectable		 1vptA-1xfjA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yis ADENYLOSUCCINATE
LYASE

(Caenorhabditis
elegans) 		PF00206
(Lyase_1) 		3 ASP A 136
ARG A 137
ASP A 468
 None
 0.88A 1vptA-1yisA:
undetectable		 1vptA-1yisA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6r MLC PROTEIN

(Escherichia
coli) 		PF00480
(ROK) 		3 ASP A 195
ARG A  91
ASP A 221
 None
 0.89A 1vptA-1z6rA:
undetectable		 1vptA-1z6rA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aeu HYPOTHETICAL PROTEIN
MJ0158

(Methanocaldococcus
jannaschii) 		PF03841
(SelA) 		3 ASP A 351
ARG A 350
ASP A  28
 None
SO4  A1010 (-2.6A)
None
 0.82A 1vptA-2aeuA:
2.5		 1vptA-2aeuA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2an2 P332G A333S DOUBLE
MUTANT OF NITRIC
OXIDE SYNTHASE FROM
BACILLUS SUBTILIS

(Bacillus
subtilis) 		PF02898
(NO_synthase) 		3 ASP A 141
ARG A 128
ASP A 247
 None
ARG  A2000 (-4.0A)
None
 0.91A 1vptA-2an2A:
undetectable		 1vptA-2an2A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fo1 LIN-12 PROTEIN

(Caenorhabditis
elegans) 		PF00023
(Ank)
PF12796
(Ank_2) 		3 ASP E1139
ARG E1107
ASP E1177
 None
 0.77A 1vptA-2fo1E:
undetectable		 1vptA-2fo1E:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fym ENOLASE

(Escherichia
coli) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		3 ASP A 400
ARG A 398
ASP A  13
 None
 0.87A 1vptA-2fymA:
undetectable		 1vptA-2fymA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g85 CHORISMATE SYNTHASE

(Mycobacterium
tuberculosis) 		PF01264
(Chorismate_synt) 		3 ASP A 128
ARG A 130
ASP A 117
 None
 0.94A 1vptA-2g85A:
undetectable		 1vptA-2g85A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j1l RHO-RELATED
GTP-BINDING PROTEIN
RHOD

(Homo sapiens) 		PF00071
(Ras) 		3 ASP A 132
ARG A 174
ASP A 136
 GDP  A1194 (-2.9A)
GDP  A1194 (-4.6A)
None
 0.92A 1vptA-2j1lA:
undetectable		 1vptA-2j1lA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k4z DSRR

(Allochromatium
vinosum) 		PF01521
(Fe-S_biosyn) 		3 ASP A  51
ARG A  27
ASP A  66
 None
 0.77A 1vptA-2k4zA:
undetectable		 1vptA-2k4zA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kbq HARMONIN

(Homo sapiens) 		no annotation 3 ASP A  14
ARG A  10
ASP A  20
 None
 0.90A 1vptA-2kbqA:
undetectable		 1vptA-2kbqA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m5t HUMAN RHINOVIRUS 2A
PROTEINASE

(Rhinovirus C) 		PF00947
(Pico_P2A) 		3 ASP A 131
ARG A 133
ASP A  75
 None
 0.93A 1vptA-2m5tA:
undetectable		 1vptA-2m5tA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pjq UNCHARACTERIZED
PROTEIN LP_2664

(Lactobacillus
plantarum) 		PF01966
(HD) 		3 ASP A  43
ARG A  39
ASP A 188
 None
 0.94A 1vptA-2pjqA:
undetectable		 1vptA-2pjqA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qdd MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Roseovarius
nubinhibens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ASP A  39
ARG A  37
ASP A 368
 None
 0.84A 1vptA-2qddA:
undetectable		 1vptA-2qddA:
19.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vp3 VP39

(Vaccinia virus) 		PF01358
(PARP_regulatory) 		3 ASP A  95
ARG A  97
ASP A 138
 SAH  A 400 (-2.6A)
SAH  A 400 (-3.9A)
SAH  A 400 (-3.7A)
 0.39A 1vptA-2vp3A:
48.5		 1vptA-2vp3A:
99.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yh2 ESTERASE

(Pyrobaculum
calidifontis) 		PF07859
(Abhydrolase_3) 		3 ASP A  23
ARG A  21
ASP A  25
 None
 0.79A 1vptA-2yh2A:
undetectable		 1vptA-2yh2A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Mus musculus) 		PF11921
(DUF3439)
PF13306
(LRR_5)
PF13516
(LRR_6)
PF13855
(LRR_8) 		3 ASP A  58
ARG A  39
ASP A 106
 None
 0.68A 1vptA-2z81A:
undetectable		 1vptA-2z81A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ab0 BCLA PROTEIN
ANTIBODY SCFV
FRAGMENT, HEAVY
CHAIN

(Bacillus
anthracis;
Mus musculus) 		no annotation
PF07686
(V-set) 		3 ASP A 124
ARG B  99
ASP A 103
 None
 0.96A 1vptA-3ab0A:
undetectable		 1vptA-3ab0A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahi XYLULOSE
5-PHOSPHATE/FRUCTOSE
6-PHOSPHATE
PHOSPHOKETOLASE

(Bifidobacterium
breve) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		3 ASP A 753
ARG A 781
ASP A 745
 None
 0.94A 1vptA-3ahiA:
undetectable		 1vptA-3ahiA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai7 XYLULOSE-5-PHOSPHATE
/FRUCTOSE-6-PHOSPHAT
E PHOSPHOKETOLASE

(Bifidobacterium
longum) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		3 ASP A 753
ARG A 781
ASP A 745
 None
 0.83A 1vptA-3ai7A:
undetectable		 1vptA-3ai7A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5w PP2A-SPECIFIC
METHYLESTERASE PME-1

(Homo sapiens) 		PF12697
(Abhydrolase_6) 		3 ASP P 354
ARG P 222
ASP P 181
 None
 0.73A 1vptA-3c5wP:
2.9		 1vptA-3c5wP:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e49 UNCHARACTERIZED
PROTEIN DUF849 WITH
A TIM BARREL FOLD

(Paraburkholderia
xenovorans) 		PF05853
(BKACE) 		3 ASP A  54
ARG A  56
ASP A  63
 None
 0.85A 1vptA-3e49A:
undetectable		 1vptA-3e49A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gov MASP-1

(Homo sapiens) 		PF00089
(Trypsin) 		3 ASP B 507
ARG B 504
ASP B 497
 None
 0.96A 1vptA-3govB:
undetectable		 1vptA-3govB:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwb PEPTIDASE M16
INACTIVE DOMAIN
FAMILY PROTEIN

(Pseudomonas
protegens) 		PF05193
(Peptidase_M16_C) 		3 ASP A  37
ARG A 100
ASP A 367
 None
 0.76A 1vptA-3gwbA:
undetectable		 1vptA-3gwbA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3isr TRANSGLUTAMINASE-LIK
E ENZYMES, PUTATIVE
CYSTEINE PROTEASE

(Cytophaga
hutchinsonii) 		PF01841
(Transglut_core) 		3 ASP A 172
ARG A 171
ASP A 161
 None
 0.62A 1vptA-3isrA:
undetectable		 1vptA-3isrA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k0z PUTATIVE POLYKETIDE
CYCLASE

(Bacillus cereus) 		PF07366
(SnoaL) 		3 ASP A  84
ARG A  91
ASP A 147
 None
NHE  A   1 (-3.9A)
None
 0.83A 1vptA-3k0zA:
undetectable		 1vptA-3k0zA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lah METHYL-ACCEPTING
CHEMOTAXIS PROTEIN

(Caldanaerobacter
subterraneus) 		PF07700
(HNOB) 		3 ASP A  45
ARG A 135
ASP A  42
 None
HEM  A 200 (-3.6A)
None
 0.66A 1vptA-3lahA:
undetectable		 1vptA-3lahA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lg5 EPI-ISOZIZAENE
SYNTHASE

(Streptomyces
coelicolor) 		no annotation 3 ASP A 103
ARG A 104
ASP A 252
 None
 0.89A 1vptA-3lg5A:
undetectable		 1vptA-3lg5A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3md0 ARGININE/ORNITHINE
TRANSPORT SYSTEM
ATPASE

(Mycobacterium
tuberculosis) 		PF03308
(ArgK) 		3 ASP A 173
ARG A  60
ASP A 271
 None
 0.96A 1vptA-3md0A:
undetectable		 1vptA-3md0A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3moi PROBABLE
DEHYDROGENASE

(Bordetella
bronchiseptica) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 ASP A 155
ARG A 159
ASP A 239
 None
 0.82A 1vptA-3moiA:
2.8		 1vptA-3moiA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n05 NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Streptomyces
avermitilis) 		PF00795
(CN_hydrolase)
PF02540
(NAD_synthase) 		3 ASP A 523
ARG A 571
ASP A 521
 None
 0.87A 1vptA-3n05A:
undetectable		 1vptA-3n05A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwr A RUBISCO-LIKE
PROTEIN

(Paraburkholderia
fungorum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		3 ASP A 192
ARG A 399
ASP A 157
 SO4  A 434 ( 4.8A)
SO4  A 434 (-3.1A)
None
 0.60A 1vptA-3nwrA:
undetectable		 1vptA-3nwrA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psg PEPSINOGEN

(Sus scrofa) 		PF00026
(Asp)
PF07966
(A1_Propeptide) 		3 ASP A 149
ARG A 315
ASP A 142
 None
 0.82A 1vptA-3psgA:
undetectable		 1vptA-3psgA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s51 FANCONI ANEMIA GROUP
I PROTEIN HOMOLOG

(Mus musculus) 		PF14674
(FANCI_S1-cap)
PF14675
(FANCI_S1)
PF14676
(FANCI_S2)
PF14677
(FANCI_S3)
PF14678
(FANCI_S4)
PF14679
(FANCI_HD1)
PF14680
(FANCI_HD2) 		3 ASP A  28
ARG A  64
ASP A  26
 None
 0.92A 1vptA-3s51A:
undetectable		 1vptA-3s51A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s7i ALLERGEN ARA H 1,
CLONE P41B

(Arachis
hypogaea) 		PF00190
(Cupin_1) 		3 ASP A 300
ARG A 185
ASP A 231
 None
 0.91A 1vptA-3s7iA:
undetectable		 1vptA-3s7iA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqp ENOLASE

(Coxiella
burnetii) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		3 ASP A 396
ARG A 394
ASP A  15
 None
 0.84A 1vptA-3tqpA:
undetectable		 1vptA-3tqpA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u95 GLYCOSIDE HYDROLASE,
FAMILY 4

(Thermotoga
neapolitana) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		3 ASP A 294
ARG A 299
ASP A 267
 None
None
MN  A 601 ( 4.6A)
 0.78A 1vptA-3u95A:
3.1		 1vptA-3u95A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zf4 DUTPASE

(Staphylococcus
virus 80alpha) 		PF00692
(dUTPase) 		3 ASP A  28
ARG A  64
ASP A  24
 None
 0.88A 1vptA-3zf4A:
undetectable		 1vptA-3zf4A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3r ENOLASE

(Bacillus
subtilis) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		3 ASP A 398
ARG A 396
ASP A  14
 None
 0.86A 1vptA-4a3rA:
undetectable		 1vptA-4a3rA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af1 PEPTIDE CHAIN
RELEASE FACTOR
SUBUNIT 1

(Halobacterium
salinarum) 		PF03463
(eRF1_1)
PF03464
(eRF1_2)
PF03465
(eRF1_3) 		3 ASP A 329
ARG A 347
ASP A 373
 None
 0.93A 1vptA-4af1A:
undetectable		 1vptA-4af1A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cr4 26S PROTEASE
REGULATORY SUBUNIT
6B HOMOLOG
26S PROTEASE SUBUNIT
RPT4

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF00004
(AAA) 		3 ASP K 153
ARG L 126
ASP K 256
 None
 0.84A 1vptA-4cr4K:
undetectable		 1vptA-4cr4K:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewj ENOLASE 2

(Streptococcus
suis) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		3 ASP A 403
ARG A 401
ASP A  14
 None
 0.89A 1vptA-4ewjA:
undetectable		 1vptA-4ewjA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnq ALPHA-GALACTOSIDASE
AGAB

(Geobacillus
stearothermophilus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		3 ASP A  64
ARG A  27
ASP A  53
 None
 0.90A 1vptA-4fnqA:
undetectable		 1vptA-4fnqA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		3 ASP A 204
ARG A 209
ASP A 255
 SAM  A 401 (-2.9A)
SAM  A 401 (-3.6A)
SAM  A 401 (-3.7A)
 0.39A 1vptA-4fzvA:
6.4		 1vptA-4fzvA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3n DNA GYRASE SUBUNIT A

(Mycobacterium
tuberculosis) 		PF03989
(DNA_gyraseA_C) 		3 ASP A 565
ARG A 615
ASP A 515
 None
 0.69A 1vptA-4g3nA:
undetectable		 1vptA-4g3nA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gr4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE

(Streptomyces
lydicus) 		PF00501
(AMP-binding)
PF03621
(MbtH) 		3 ASP A 346
ARG A 345
ASP A 316
 None
 0.93A 1vptA-4gr4A:
undetectable		 1vptA-4gr4A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3z D-ERYTHRULOSE
4-PHOSPHATE
DEHYDROGENASE

(Brucella
melitensis) 		no annotation 3 ASP A  34
ARG A  68
ASP A 302
 None
 0.87A 1vptA-4k3zA:
undetectable		 1vptA-4k3zA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l27 CYSTATHIONINE
BETA-SYNTHASE

(Homo sapiens) 		no annotation 3 ASP B 309
ARG B 196
ASP B  47
 None
 0.89A 1vptA-4l27B:
undetectable		 1vptA-4l27B:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mks ENOLASE 2

(Lactobacillus
gasseri) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		3 ASP A 398
ARG A 396
ASP A  14
 None
 0.82A 1vptA-4mksA:
undetectable		 1vptA-4mksA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ow2 YOP EFFECTOR YOPM

(Yersinia
enterocolitica) 		PF12468
(TTSSLRR) 		3 ASP A 357
ARG A 377
ASP A 339
 None
 0.80A 1vptA-4ow2A:
undetectable		 1vptA-4ow2A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfv ANK-N5C-281

(synthetic
construct) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4) 		3 ASP A  35
ARG A  14
ASP A  68
 None
 0.90A 1vptA-4qfvA:
undetectable		 1vptA-4qfvA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi4 CELLOBIOSE
DEHYDROGENASE

(Crassicarpon
hotsonii) 		PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C) 		3 ASP A 712
ARG A 714
ASP A 722
 None
 0.87A 1vptA-4qi4A:
undetectable		 1vptA-4qi4A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi6 CELLOBIOSE
DEHYDROGENASE

(Crassicarpon
hotsonii) 		PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C)
PF16010
(CDH-cyt) 		3 ASP A 712
ARG A 714
ASP A 722
 None
 0.78A 1vptA-4qi6A:
undetectable		 1vptA-4qi6A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi7 CELLOBIOSE
DEHYDROGENASE

(Neurospora
crassa) 		PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C)
PF16010
(CDH-cyt) 		3 ASP A 711
ARG A 713
ASP A 721
 None
 0.87A 1vptA-4qi7A:
undetectable		 1vptA-4qi7A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7o GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PUTATIVE

(Bacillus
anthracis) 		PF03009
(GDPD) 		3 ASP A  86
ARG A  91
ASP A  72
 None
None
MG  A 401 (-3.0A)
 0.82A 1vptA-4r7oA:
undetectable		 1vptA-4r7oA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhb LPS-ASSEMBLY PROTEIN
LPTD

(Escherichia
coli) 		PF04453
(OstA_C) 		3 ASP A 488
ARG A 511
ASP A 543
 None
 0.97A 1vptA-4rhbA:
undetectable		 1vptA-4rhbA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tlv ADP-RIBOSYLATING
TOXIN CARDS

(Mycoplasma
pneumoniae) 		PF02917
(Pertussis_S1) 		3 ASP A 589
ARG A 530
ASP A 586
 None
None
GOL  A 605 ( 4.8A)
 0.67A 1vptA-4tlvA:
undetectable		 1vptA-4tlvA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wdr HALOALKANE
DEHALOGENASE

(Sphingobium
japonicum) 		PF00561
(Abhydrolase_1) 		3 ASP A 116
ARG A  86
ASP A 226
 None
 0.88A 1vptA-4wdrA:
undetectable		 1vptA-4wdrA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wh3 N-ACETYLHEXOSAMINE
1-KINASE

(Bifidobacterium
longum) 		PF01636
(APH) 		3 ASP A 243
ARG A 246
ASP A 208
 GOL  A 406 (-2.8A)
GOL  A 406 (-4.0A)
GOL  A 406 (-3.2A)
 0.84A 1vptA-4wh3A:
undetectable		 1vptA-4wh3A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xl5 BGFP-A

(synthetic
construct) 		PF02985
(HEAT)
PF13646
(HEAT_2) 		3 ASP C  74
ARG C  76
ASP C  43
 None
 0.95A 1vptA-4xl5C:
undetectable		 1vptA-4xl5C:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y1b ANTE

(Streptomyces
sp. NRRL 2288) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 ASP A 203
ARG A 200
ASP A 315
 None
 0.80A 1vptA-4y1bA:
4.6		 1vptA-4y1bA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z17 ENOLASE

(Chloroflexus
aurantiacus) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		3 ASP A 397
ARG A 395
ASP A  15
 None
 0.89A 1vptA-4z17A:
undetectable		 1vptA-4z17A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zud CHIMERA PROTEIN OF
SOLUBLE CYTOCHROME
B562 AND TYPE-1
ANGIOTENSIN II
RECEPTOR

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		3 ASP A1073
ARG A1034
ASP A1066
 None
 0.89A 1vptA-4zudA:
undetectable		 1vptA-4zudA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zv6 ALPHAREP-7

(synthetic
construct) 		PF13646
(HEAT_2) 		3 ASP A 120
ARG A 122
ASP A  89
 None
 0.95A 1vptA-4zv6A:
undetectable		 1vptA-4zv6A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5auo ATPASE INVOLVED IN
CHROMOSOME
PARTITIONING,
PARA/MIND FAMILY,
MRP HOMOLOG

(Thermococcus
kodakarensis) 		PF10609
(ParA) 		3 ASP B 143
ARG B 146
ASP B 112
 None
 0.90A 1vptA-5auoB:
undetectable		 1vptA-5auoB:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST

(Pseudomonas
aeruginosa) 		no annotation 3 ASP A 473
ARG A  46
ASP A 471
 None
 0.93A 1vptA-5b7iA:
undetectable		 1vptA-5b7iA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5boe ENOLASE

(Staphylococcus
aureus) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		3 ASP A 402
ARG A 400
ASP A  14
 None
 0.87A 1vptA-5boeA:
undetectable		 1vptA-5boeA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp1 MYCOCEROSIC ACID
SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		3 ASP A 254
ARG A 252
ASP A 259
 None
 0.96A 1vptA-5bp1A:
undetectable		 1vptA-5bp1A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5diy HYALURONIDASE

(Thermobaculum
terrenum) 		PF07555
(NAGidase) 		3 ASP A 143
ARG A 147
ASP A 130
 None
 0.88A 1vptA-5diyA:
undetectable		 1vptA-5diyA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eeb ALDEHYDE
DEHYDROGENASE

(Pyrobaculum
ferrireducens) 		PF00171
(Aldedh) 		3 ASP A 405
ARG A 374
ASP A 407
 None
 0.80A 1vptA-5eebA:
undetectable		 1vptA-5eebA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmx CARBOXYLESTERASE

(uncultured
bacterium) 		PF00144
(Beta-lactamase) 		3 ASP A  98
ARG A  95
ASP A  91
 None
 0.93A 1vptA-5gmxA:
undetectable		 1vptA-5gmxA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gy0 GLUCANASE

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9)
PF00942
(CBM_3) 		3 ASP A 144
ARG A 390
ASP A  76
 None
 0.93A 1vptA-5gy0A:
undetectable		 1vptA-5gy0A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus) 		no annotation 3 ASP C  18
ARG C 257
ASP C 251
 None
 0.93A 1vptA-5h9uC:
undetectable		 1vptA-5h9uC:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE

(Saccharomyces
cerevisiae) 		PF00067
(p450) 		3 ASP A  54
ARG A  52
ASP A 390
 None
 0.82A 1vptA-5hs1A:
undetectable		 1vptA-5hs1A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5it9 RIBOSOMAL PROTEIN
RACK1

(Kluyveromyces
lactis) 		PF01092
(Ribosomal_S6e) 		3 ASP g 271
ARG g 256
ASP g 279
 None
 0.93A 1vptA-5it9g:
undetectable		 1vptA-5it9g:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j46 PEPTIDE DEFORMYLASE

(Burkholderia
multivorans) 		PF01327
(Pep_deformylase) 		3 ASP A  39
ARG A  41
ASP A  36
 None
 0.55A 1vptA-5j46A:
undetectable		 1vptA-5j46A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdj F5/8 TYPE C DOMAIN
PROTEIN

(Clostridium
perfringens) 		no annotation 3 ASP B 871
ARG B 851
ASP B 895
 None
 0.67A 1vptA-5kdjB:
undetectable		 1vptA-5kdjB:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lu4 PYRUVATE, PHOSPHATE
DIKINASE,
CHLOROPLASTIC

(Flaveria
trinervia) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		3 ASP A 133
ARG A 137
ASP A 170
 None
 0.92A 1vptA-5lu4A:
undetectable		 1vptA-5lu4A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mjv CAPSID SUBUNIT VP1
CAPSID SUBUNIT VP0

(Parechovirus A;
Parechovirus A) 		no annotation
PF00073
(Rhv) 		3 ASP A 134
ARG A 139
ASP C 288
 None
 0.85A 1vptA-5mjvA:
undetectable		 1vptA-5mjvA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mm4 KINESIN-5

(Ustilago maydis) 		no annotation 3 ASP K 176
ARG K 231
ASP K 171
 None
 0.95A 1vptA-5mm4K:
undetectable		 1vptA-5mm4K:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ogx CYTOCHROME P450
REDUCTASE

(Amycolatopsis
methanolica) 		no annotation 3 ASP A 247
ARG A 164
ASP A 272
 None
 0.71A 1vptA-5ogxA:
4.0		 1vptA-5ogxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vft PROTEASOME SUBUNIT
BETA TYPE-4

(Homo sapiens) 		no annotation 3 ASP T  25
ARG T  41
ASP T 180
 None
 0.89A 1vptA-5vftT:
undetectable		 1vptA-5vftT:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vpu 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Acinetobacter
baumannii) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		3 ASP A 488
ARG A 508
ASP A  56
 None
 0.66A 1vptA-5vpuA:
undetectable		 1vptA-5vpuA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4t CADHERIN 23

(Danio rerio) 		no annotation 3 ASP C 237
ARG C 244
ASP C 208
 CA  C 407 (-2.7A)
None
None
 0.64A 1vptA-5w4tC:
undetectable		 1vptA-5w4tC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wm4 SALICYLATE-AMP
LIGASE

(Streptomyces
gandocaensis) 		no annotation 3 ASP A 226
ARG A  37
ASP A 204
 None
 0.65A 1vptA-5wm4A:
undetectable		 1vptA-5wm4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x5t ALPHA-KETOGLUTARIC
SEMIALDEHYDE
DEHYDROGENASE

(Azospirillum
brasilense) 		PF00171
(Aldedh) 		3 ASP A  47
ARG A  50
ASP A  19
 None
 0.95A 1vptA-5x5tA:
undetectable		 1vptA-5x5tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ydn GENE PRODUCT J

(Escherichia
virus Mu) 		no annotation 3 ASP A  19
ARG A  15
ASP A  32
 None
 0.76A 1vptA-5ydnA:
undetectable		 1vptA-5ydnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6erc PEROXINECTIN A

(Dictyostelium
discoideum) 		no annotation 3 ASP A 454
ARG A 408
ASP A 452
 None
 0.91A 1vptA-6ercA:
undetectable		 1vptA-6ercA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fai SERINE/THREONINE-PRO
TEIN KINASE RIO2

(Saccharomyces
cerevisiae) 		no annotation 3 ASP l  81
ARG l 126
ASP l   4
 None
 0.97A 1vptA-6fail:
undetectable		 1vptA-6fail:
undetectable