SIMILAR PATTERNS OF AMINO ACIDS FOR 1VM1_A_TAZA504

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bbt FOOT-AND-MOUTH
DISEASE VIRUS
(SUBUNIT VP1)

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		3 ASP 1  75
TYR 1 119
GLU 1 184
 None
 0.85A 1vm1A-1bbt1:
undetectable		 1vm1A-1bbt1:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbn PROTEIN
(LEUKOAGGLUTININ)

(Maackia
amurensis) 		PF00139
(Lectin_legB) 		3 ASP A 137
TYR A 136
GLU A 224
 GAL  A 823 ( 3.1A)
GAL  A 823 ( 4.0A)
BGC  A 824 (-2.8A)
 0.82A 1vm1A-1dbnA:
0.0		 1vm1A-1dbnA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dms DMSO REDUCTASE

(Rhodobacter
capsulatus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		3 ASP A 613
TYR A 612
GLU A 331
 None
 0.83A 1vm1A-1dmsA:
0.0		 1vm1A-1dmsA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dqu ISOCITRATE LYASE

(Aspergillus
nidulans) 		PF00463
(ICL) 		3 ASP A 400
TYR A 401
GLU A 438
 None
 0.76A 1vm1A-1dquA:
1.1		 1vm1A-1dquA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eu1 DIMETHYL SULFOXIDE
REDUCTASE

(Rhodobacter
sphaeroides) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		3 ASP A 613
TYR A 612
GLU A 331
 None
 0.86A 1vm1A-1eu1A:
0.0		 1vm1A-1eu1A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fc9 PHOTOSYSTEM II D1
PROTEASE

(Tetradesmus
obliquus) 		PF03572
(Peptidase_S41)
PF13180
(PDZ_2) 		3 ASP A 127
TYR A 126
GLU A  81
 None
 0.83A 1vm1A-1fc9A:
0.0		 1vm1A-1fc9A:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flg PROTEIN
(QUINOPROTEIN
ETHANOL
DEHYDROGENASE)

(Pseudomonas
aeruginosa) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		3 ASP A 463
TYR A 461
GLU A 481
 None
 0.84A 1vm1A-1flgA:
0.0		 1vm1A-1flgA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ge7 PEPTIDYL-LYS
METALLOENDOPEPTIDASE

(Grifola
frondosa) 		PF14521
(Aspzincin_M35) 		3 ASP A 130
TYR A 133
GLU A 157
 ZN  A 200 (-1.9A)
None
None
 0.82A 1vm1A-1ge7A:
0.0		 1vm1A-1ge7A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htw HI0065

(Haemophilus
influenzae) 		PF02367
(TsaE) 		3 ASP A  85
TYR A  87
GLU A 116
 None
 0.77A 1vm1A-1htwA:
0.0		 1vm1A-1htwA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iuz PLASTOCYANIN

(Ulva pertusa) 		PF00127
(Copper-bind) 		3 ASP A  61
TYR A  62
GLU A  85
 None
 0.87A 1vm1A-1iuzA:
undetectable		 1vm1A-1iuzA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kon PROTEIN YEBC

(Escherichia
coli) 		PF01709
(Transcrip_reg) 		3 ASP A 166
TYR A 165
GLU A 237
 None
 0.73A 1vm1A-1konA:
undetectable		 1vm1A-1konA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ku1 ARF
GUANINE-NUCLEOTIDE
EXCHANGE FACTOR 2

(Saccharomyces
cerevisiae) 		PF01369
(Sec7) 		3 ASP A 745
TYR A 748
GLU A 724
 None
 0.49A 1vm1A-1ku1A:
undetectable		 1vm1A-1ku1A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lar PROTEIN (LAR)

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ASP A1667
TYR A1668
GLU A1651
 None
 0.85A 1vm1A-1larA:
undetectable		 1vm1A-1larA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lla HEMOCYANIN (SUBUNIT
TYPE II)

(Limulus
polyphemus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 ASP A 194
TYR A 590
GLU A 198
 None
 0.86A 1vm1A-1llaA:
undetectable		 1vm1A-1llaA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ltd FLAVOCYTOCHROME B2

(Saccharomyces
cerevisiae) 		PF00173
(Cyt-b5)
PF01070
(FMN_dh) 		3 ASP A 127
TYR A 126
GLU A 457
 None
 0.80A 1vm1A-1ltdA:
undetectable		 1vm1A-1ltdA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mky PROBABLE GTP-BINDING
PROTEIN ENGA

(Thermotoga
maritima) 		PF01926
(MMR_HSR1)
PF14714
(KH_dom-like) 		3 ASP A 327
TYR A 324
GLU A 289
 None
 0.83A 1vm1A-1mkyA:
undetectable		 1vm1A-1mkyA:
20.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n9b BETA-LACTAMASE SHV-2

(Klebsiella
pneumoniae) 		PF13354
(Beta-lactamase2) 		3 ASP A 104
TYR A 105
GLU A 110
 None
EPE  A 400 (-3.6A)
None
 0.30A 1vm1A-1n9bA:
47.5		 1vm1A-1n9bA:
99.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pii N-(5'PHOSPHORIBOSYL)
ANTHRANILATE
ISOMERASE

(Escherichia
coli) 		PF00218
(IGPS)
PF00697
(PRAI) 		3 ASP A  41
TYR A  40
GLU A 157
 None
 0.84A 1vm1A-1piiA:
undetectable		 1vm1A-1piiA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qcw FLAVOCYTOCHROME B2

(Saccharomyces
cerevisiae) 		PF01070
(FMN_dh) 		3 ASP A 127
TYR A 126
GLU A 457
 None
 0.78A 1vm1A-1qcwA:
undetectable		 1vm1A-1qcwA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgc PROTEIN (VIRUS
CAPSID PROTEIN VP1)

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		3 ASP 1  75
TYR 1 119
GLU 1 184
 None
 0.80A 1vm1A-1qgc1:
undetectable		 1vm1A-1qgc1:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qox BETA-GLUCOSIDASE

(Bacillus
circulans) 		PF00232
(Glyco_hydro_1) 		3 ASP A 235
TYR A 229
GLU A 315
 None
 0.64A 1vm1A-1qoxA:
undetectable		 1vm1A-1qoxA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rmu HUMAN RHINOVIRUS 14
COAT PROTEIN
(SUBUNIT VP1)

(Rhinovirus B) 		PF00073
(Rhv) 		3 ASP 1 125
TYR 1 190
GLU 1 251
 None
 0.63A 1vm1A-1rmu1:
undetectable		 1vm1A-1rmu1:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svd RIBULOSE
BISPHOSPHATE
CARBOXYLASE SMALL
CHAIN
RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E LARGE SUBUNIT

(Halothiobacillus
neapolitanus) 		PF00016
(RuBisCO_large)
PF00101
(RuBisCO_small)
PF02788
(RuBisCO_large_N) 		3 ASP M   6
TYR M   7
GLU A 184
 None
 0.86A 1vm1A-1svdM:
undetectable		 1vm1A-1svdM:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tr1 BETA-GLUCOSIDASE A

(Paenibacillus
polymyxa) 		PF00232
(Glyco_hydro_1) 		3 ASP A 235
TYR A 229
GLU A 313
 None
 0.73A 1vm1A-1tr1A:
undetectable		 1vm1A-1tr1A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tzb GLUCOSE-6-PHOSPHATE
ISOMERASE,
CONJECTURAL

(Pyrobaculum
aerophilum) 		PF10432
(bact-PGI_C) 		3 ASP A  53
TYR A 195
GLU A 188
 GOL  A 801 (-2.8A)
GOL  A 801 (-3.5A)
None
 0.84A 1vm1A-1tzbA:
undetectable		 1vm1A-1tzbA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)

(Escherichia
coli) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		3 ASP A 218
TYR A 248
GLU A 591
 None
 0.83A 1vm1A-1uaaA:
undetectable		 1vm1A-1uaaA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbj PROSTAGLANDIN F
SYNTHASE

(Trypanosoma
brucei) 		PF00248
(Aldo_ket_red) 		3 ASP A 119
TYR A  85
GLU A 125
 None
 0.77A 1vm1A-1vbjA:
undetectable		 1vm1A-1vbjA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcs VESICLE TRANSPORT
THROUGH INTERACTION
WITH T-SNARES
HOMOLOG 1A

(Mus musculus) 		PF05008
(V-SNARE) 		3 ASP A  13
TYR A  10
GLU A  52
 None
 0.84A 1vm1A-1vcsA:
undetectable		 1vm1A-1vcsA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1win FLOTILLIN 2

(Mus musculus) 		PF01145
(Band_7) 		3 ASP A 124
TYR A 128
GLU A  28
 None
 0.85A 1vm1A-1winA:
undetectable		 1vm1A-1winA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yt5 INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE

(Thermotoga
maritima) 		PF01513
(NAD_kinase) 		3 ASP A 242
TYR A 243
GLU A 174
 None
 0.86A 1vm1A-1yt5A:
undetectable		 1vm1A-1yt5A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbe COAT PROTEIN VP1

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		3 ASP 1  75
TYR 1 119
GLU 1 182
 None
 0.78A 1vm1A-1zbe1:
undetectable		 1vm1A-1zbe1:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b7l GLYCEROL-3-PHOSPHATE
CYTIDYLYLTRANSFERASE

(Staphylococcus
aureus) 		PF01467
(CTP_transf_like) 		3 ASP A  51
TYR A  52
GLU A  39
 None
 0.82A 1vm1A-2b7lA:
undetectable		 1vm1A-2b7lA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buj SERINE/THREONINE-PRO
TEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		3 ASP A  35
TYR A  33
GLU A  93
 None
 0.83A 1vm1A-2bujA:
undetectable		 1vm1A-2bujA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e9x DNA REPLICATION
COMPLEX GINS PROTEIN
PSF1

(Homo sapiens) 		no annotation 3 ASP A  82
TYR A  79
GLU A 110
 None
 0.85A 1vm1A-2e9xA:
undetectable		 1vm1A-2e9xA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ejc PANTOATE--BETA-ALANI
NE LIGASE

(Thermotoga
maritima) 		PF02569
(Pantoate_ligase) 		3 ASP A 275
TYR A 203
GLU A 210
 None
None
ZN  A 516 ( 3.3A)
 0.63A 1vm1A-2ejcA:
undetectable		 1vm1A-2ejcA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fn9 RIBOSE ABC
TRANSPORTER,
PERIPLASMIC
RIBOSE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF13407
(Peripla_BP_4) 		3 ASP A  59
TYR A  58
GLU A  33
 None
 0.85A 1vm1A-2fn9A:
undetectable		 1vm1A-2fn9A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2grv LPQW

(Mycolicibacterium
smegmatis) 		PF00496
(SBP_bac_5) 		3 ASP A 333
TYR A 336
GLU A 551
 None
 0.66A 1vm1A-2grvA:
undetectable		 1vm1A-2grvA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hdi COLICIN I RECEPTOR

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 ASP A 578
TYR A 590
GLU A  73
 None
 0.77A 1vm1A-2hdiA:
undetectable		 1vm1A-2hdiA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ia1 BH3703 PROTEIN

(Bacillus
halodurans) 		PF04634
(DUF600) 		3 ASP A 116
TYR A 114
GLU A 164
 None
 0.82A 1vm1A-2ia1A:
undetectable		 1vm1A-2ia1A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qec HISTONE
ACETYLTRANSFERASE
HPA2 AND RELATED
ACETYLTRANSFERASES

(Corynebacterium
glutamicum) 		PF00583
(Acetyltransf_1) 		3 ASP A  79
TYR A 128
GLU A 161
 None
 0.87A 1vm1A-2qecA:
undetectable		 1vm1A-2qecA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgg 16S RRNA-PROCESSING
PROTEIN RIMM

(Acinetobacter
calcoaceticus) 		PF01782
(RimM)
PF05239
(PRC) 		3 ASP A 108
TYR A 105
GLU A 103
 None
UNL  A 202 (-4.2A)
None
 0.74A 1vm1A-2qggA:
undetectable		 1vm1A-2qggA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvl DIACYLGLYCEROL
KINASE DGKB

(Staphylococcus
aureus) 		PF00781
(DAGK_cat) 		3 ASP A  60
TYR A  59
GLU A  35
 None
 0.84A 1vm1A-2qvlA:
undetectable		 1vm1A-2qvlA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v84 SPERMIDINE/PUTRESCIN
E ABC TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN

(Treponema
pallidum) 		PF13416
(SBP_bac_8) 		3 ASP A 240
TYR A 110
GLU A 211
 MES  A1326 (-3.2A)
None
None
 0.86A 1vm1A-2v84A:
undetectable		 1vm1A-2v84A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vqa SLL1358 PROTEIN

(Synechocystis
sp. PCC 6803) 		PF00190
(Cupin_1) 		3 ASP A 349
TYR A 350
GLU A 260
 None
ACT  A1395 (-4.4A)
None
 0.78A 1vm1A-2vqaA:
undetectable		 1vm1A-2vqaA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vun ENAMIDASE

(Eubacterium
barkeri) 		PF01979
(Amidohydro_1) 		3 ASP A 256
TYR A 257
GLU A 264
 None
 0.80A 1vm1A-2vunA:
undetectable		 1vm1A-2vunA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vwk DNA POLYMERASE

(Thermococcus
gorgonarius) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		3 ASP A 141
TYR A 209
GLU A 276
 None
 0.77A 1vm1A-2vwkA:
undetectable		 1vm1A-2vwkA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vy0 ENDO-BETA-1,3-GLUCAN
ASE

(Pyrococcus
furiosus) 		PF00722
(Glyco_hydro_16) 		3 ASP A 226
TYR A 224
GLU A 239
 None
 0.67A 1vm1A-2vy0A:
undetectable		 1vm1A-2vy0A:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzr POLYPROTEIN

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		3 ASP 1  76
TYR 1 120
GLU 1 190
 None
 0.82A 1vm1A-2wzr1:
undetectable		 1vm1A-2wzr1:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x40 BETA-GLUCOSIDASE

(Thermotoga
neapolitana) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		3 ASP A 584
TYR A 583
GLU A 137
 None
 0.84A 1vm1A-2x40A:
undetectable		 1vm1A-2x40A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3a PHOSPHATIDYLINOSITOL
3-KINASE REGULATORY
SUBUNIT BETA
PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT BETA ISOFORM

(Mus musculus) 		PF00017
(SH2)
PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B)
PF16454
(PI3K_P85_iSH2) 		3 ASP B 455
TYR B 458
GLU A 462
 None
 0.57A 1vm1A-2y3aB:
undetectable		 1vm1A-2y3aB:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y6i COLLAGENASE

(Hathewaya
histolytica) 		PF01752
(Peptidase_M9)
PF08453
(Peptidase_M9_N) 		3 ASP A 340
TYR A 344
GLU A 381
 1PE  A1799 (-3.8A)
1PE  A1799 ( 4.1A)
None
 0.77A 1vm1A-2y6iA:
undetectable		 1vm1A-2y6iA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y6p 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE

(Aquifex
aeolicus) 		PF02348
(CTP_transf_3) 		3 ASP A 103
TYR A 100
GLU A  96
 None
 0.85A 1vm1A-2y6pA:
undetectable		 1vm1A-2y6pA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zqq METHYLGLUTACONYL-COA
HYDRATASE

(Homo sapiens) 		PF00378
(ECH_1) 		3 ASP A 265
TYR A 268
GLU A 132
 None
 0.74A 1vm1A-2zqqA:
undetectable		 1vm1A-2zqqA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zyz TRNA-SPLICING
ENDONUCLEASE

(Pyrobaculum
aerophilum) 		PF01974
(tRNA_int_endo)
PF02778
(tRNA_int_endo_N) 		3 ASP B  34
TYR B  33
GLU B  40
 None
 0.74A 1vm1A-2zyzB:
undetectable		 1vm1A-2zyzB:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3f YVGN PROTEIN

(Bacillus
subtilis) 		PF00248
(Aldo_ket_red) 		3 ASP A 121
TYR A  87
GLU A 127
 None
 0.86A 1vm1A-3d3fA:
undetectable		 1vm1A-3d3fA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmx TARTRATE
DEHYDROGENASE/DECARB
OXYLASE

(Pseudomonas
putida) 		PF00180
(Iso_dh) 		3 ASP X  71
TYR X  70
GLU X  40
 None
 0.86A 1vm1A-3fmxX:
undetectable		 1vm1A-3fmxX:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhs PHENOLOXIDASE
SUBUNIT 2

(Manduca sexta) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 ASP A 235
TYR A 644
GLU A 239
 None
 0.87A 1vm1A-3hhsA:
undetectable		 1vm1A-3hhsA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn7 UDP-N-ACETYLMURAMATE
-L-ALANINE LIGASE

(Psychrobacter
arcticus) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		3 ASP A 183
TYR A 182
GLU A 178
 None
 0.78A 1vm1A-3hn7A:
undetectable		 1vm1A-3hn7A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE
FAD-SUBUNIT

(Eubacterium
barkeri) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		3 ASP C 256
TYR C 259
GLU C 273
 None
 0.80A 1vm1A-3hrdC:
undetectable		 1vm1A-3hrdC:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jzl PUTATIVE
CYSTATHIONINE
BETA-LYASE INVOLVED
IN ALUMINUM
RESISTANCE

(Listeria
monocytogenes) 		PF06838
(Met_gamma_lyase) 		3 ASP A 357
TYR A 350
GLU A 355
 None
 0.82A 1vm1A-3jzlA:
undetectable		 1vm1A-3jzlA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lup DEGV FAMILY PROTEIN

(Streptococcus
agalactiae) 		PF02645
(DegV) 		3 ASP A  46
TYR A  49
GLU A  39
 None
 0.83A 1vm1A-3lupA:
undetectable		 1vm1A-3lupA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m3i PUTATIVE
UNCHARACTERIZED
PROTEIN

(Leishmania
major) 		PF06172
(Cupin_5) 		3 ASP A 175
TYR A 176
GLU A  33
 None
 0.86A 1vm1A-3m3iA:
undetectable		 1vm1A-3m3iA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mel THIAMIN
PYROPHOSPHOKINASE
FAMILY PROTEIN

(Enterococcus
faecalis) 		PF04263
(TPK_catalytic)
PF04265
(TPK_B1_binding) 		3 ASP A  24
TYR A  23
GLU A  95
 None
 0.74A 1vm1A-3melA:
undetectable		 1vm1A-3melA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pu6 UNCHARACTERIZED
PROTEIN

(Wolinella
succinogenes) 		no annotation 3 ASP A  40
TYR A  39
GLU A  45
 None
 0.75A 1vm1A-3pu6A:
undetectable		 1vm1A-3pu6A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rac HISTIDINE-TRNA
LIGASE

(Alicyclobacillus
acidocaldarius) 		PF13393
(tRNA-synt_His) 		3 ASP A  65
TYR A  63
GLU A  62
 None
 0.75A 1vm1A-3racA:
undetectable		 1vm1A-3racA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tw8 DENN
DOMAIN-CONTAINING
PROTEIN 1B
RAS-RELATED PROTEIN
RAB-35

(Homo sapiens) 		PF00071
(Ras)
PF02141
(DENN)
PF03455
(dDENN)
PF03456
(uDENN) 		3 ASP B  44
TYR B  37
GLU A  44
 None
 0.85A 1vm1A-3tw8B:
undetectable		 1vm1A-3tw8B:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3upv HEAT SHOCK PROTEIN
STI1

(Saccharomyces
cerevisiae) 		PF00515
(TPR_1) 		3 ASP A 318
TYR A 299
GLU A 324
 None
 0.80A 1vm1A-3upvA:
undetectable		 1vm1A-3upvA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vbj GALACTOSIDE
O-ACETYLTRANSFERASE

(Bacillus cereus) 		PF00132
(Hexapep) 		3 ASP A  79
TYR A  78
GLU A 140
 None
 0.81A 1vm1A-3vbjA:
undetectable		 1vm1A-3vbjA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vr1 PEPTIDE CHAIN
RELEASE FACTOR 3

(Desulfovibrio
vulgaris) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF16658
(RF3_C) 		3 ASP A 486
TYR A 487
GLU A 491
 None
 0.69A 1vm1A-3vr1A:
undetectable		 1vm1A-3vr1A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aez MITOTIC SPINDLE
CHECKPOINT COMPONENT
MAD3

(Schizosaccharomyces
pombe) 		PF08311
(Mad3_BUB1_I) 		3 ASP C 170
TYR C 173
GLU C 161
 None
 0.86A 1vm1A-4aezC:
undetectable		 1vm1A-4aezC:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4are COLLAGENASE G

(Hathewaya
histolytica) 		PF01752
(Peptidase_M9)
PF08453
(Peptidase_M9_N) 		3 ASP A 340
TYR A 344
GLU A 381
 P6G  A1791 (-3.4A)
P6G  A1791 ( 3.5A)
None
 0.85A 1vm1A-4areA:
undetectable		 1vm1A-4areA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1

(Mus musculus) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		3 ASP A 631
TYR A 634
GLU A 628
 None
 0.75A 1vm1A-4b56A:
undetectable		 1vm1A-4b56A:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gh4 CAPSID PROTEIN VP1

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		3 ASP A  75
TYR A 119
GLU A 183
 None
 0.81A 1vm1A-4gh4A:
undetectable		 1vm1A-4gh4A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4heq FLAVODOXIN

(Desulfovibrio
gigas) 		PF00258
(Flavodoxin_1) 		3 ASP A  51
TYR A  50
GLU A  32
 None
 0.77A 1vm1A-4heqA:
undetectable		 1vm1A-4heqA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igl YENC2

(Yersinia
entomophaga) 		no annotation 3 ASP B 588
TYR B 587
GLU B 292
 None
 0.84A 1vm1A-4iglB:
undetectable		 1vm1A-4iglB:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irt UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF15892
(BNR_4) 		3 ASP A 153
TYR A 173
GLU A 100
 None
 0.74A 1vm1A-4irtA:
undetectable		 1vm1A-4irtA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4je1 PROBABLE THIOL
PEROXIDASE

(Burkholderia
cenocepacia) 		PF08534
(Redoxin) 		3 ASP A 160
TYR A 159
GLU A 148
 None
 0.66A 1vm1A-4je1A:
undetectable		 1vm1A-4je1A:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lru GLYOXALASE III
(GLUTATHIONE-INDEPEN
DENT)

(Candida
albicans) 		PF01965
(DJ-1_PfpI) 		3 ASP A  98
TYR A  97
GLU A  42
 None
 0.77A 1vm1A-4lruA:
undetectable		 1vm1A-4lruA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n5a PROTEIN EFR3

(Saccharomyces
cerevisiae) 		no annotation 3 ASP A  97
TYR A 100
GLU A 142
 None
 0.82A 1vm1A-4n5aA:
undetectable		 1vm1A-4n5aA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		3 ASP A2089
TYR A2088
GLU A1798
 None
 0.81A 1vm1A-4o9xA:
undetectable		 1vm1A-4o9xA:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pz0 SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN

(Bacillus
anthracis) 		PF13407
(Peripla_BP_4) 		3 ASP A 218
TYR A 216
GLU A 191
 None
 0.72A 1vm1A-4pz0A:
undetectable		 1vm1A-4pz0A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tmc OLD YELLOW ENZYME

(Kluyveromyces
marxianus) 		PF00724
(Oxidored_FMN) 		3 ASP A 370
TYR A 369
GLU A 399
 None
 0.81A 1vm1A-4tmcA:
undetectable		 1vm1A-4tmcA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dc4 AS25 MONOBODY

(Homo sapiens) 		PF00041
(fn3) 		3 ASP B  32
TYR B  77
GLU B  51
 None
 0.85A 1vm1A-5dc4B:
undetectable		 1vm1A-5dc4B:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f12 NAD(P)H
DEHYDROGENASE
(QUINONE)

(Escherichia
coli) 		PF03358
(FMN_red) 		3 ASP A  69
TYR A  68
GLU A  32
 None
 0.84A 1vm1A-5f12A:
undetectable		 1vm1A-5f12A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fwx GLUTAMATE RECEPTOR 4

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		3 ASP B 191
TYR B 137
GLU B 166
 None
 0.85A 1vm1A-5fwxB:
undetectable		 1vm1A-5fwxB:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kis RHS2

(Yersinia
entomophaga) 		no annotation 3 ASP B 587
TYR B 586
GLU B 292
 None
 0.81A 1vm1A-5kisB:
undetectable		 1vm1A-5kisB:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lcx (-)-ISOPIPERITENONE
REDUCTASE

(Mentha x
piperita) 		PF00106
(adh_short) 		3 ASP A 115
TYR A 111
GLU A 142
 None
 0.84A 1vm1A-5lcxA:
undetectable		 1vm1A-5lcxA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mul NEURAMINIDASE

(Bacteroides
thetaiotaomicron) 		PF15892
(BNR_4) 		3 ASP A 153
TYR A 173
GLU A 100
 None
 0.87A 1vm1A-5mulA:
undetectable		 1vm1A-5mulA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mvh BACCELL_00856

(Bacteroides
cellulosilyticus) 		PF15892
(BNR_4) 		3 ASP A 153
TYR A 173
GLU A 100
 None
 0.86A 1vm1A-5mvhA:
undetectable		 1vm1A-5mvhA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n0c TETANUS TOXIN

(Clostridium
tetani) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		3 ASP A1125
TYR A1124
GLU A1185
 None
 0.85A 1vm1A-5n0cA:
undetectable		 1vm1A-5n0cA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngj TAIL TUBE PROTEIN

(Escherichia
virus T5) 		no annotation 3 ASP A 193
TYR A 196
GLU A  27
 None
 0.74A 1vm1A-5ngjA:
undetectable		 1vm1A-5ngjA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nnp PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF00583
(Acetyltransf_1) 		3 ASP B 160
TYR B 116
GLU B 141
 None
 0.78A 1vm1A-5nnpB:
undetectable		 1vm1A-5nnpB:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odr HETERODISULFIDE
REDUCTASE, SUBUNIT A

(Methanothermococcus
thermolithotrophicus) 		PF07992
(Pyr_redox_2)
PF13187
(Fer4_9) 		3 ASP A 309
TYR A 240
GLU A 295
 None
 0.68A 1vm1A-5odrA:
undetectable		 1vm1A-5odrA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t2u OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN

(Mycolicibacterium
smegmatis) 		PF13561
(adh_short_C2) 		3 ASP A 234
TYR A 238
GLU A 155
 None
 0.79A 1vm1A-5t2uA:
undetectable		 1vm1A-5t2uA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tfm CADHERIN-23

(Homo sapiens) 		no annotation 3 ASP A 727
TYR A 681
GLU A 607
 CA  A 901 (-3.5A)
None
CA  A 902 ( 2.2A)
 0.86A 1vm1A-5tfmA:
undetectable		 1vm1A-5tfmA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ukh UNCHARACTERIZED
PROTEIN

(Streptococcus
intermedius) 		no annotation 3 ASP A 512
TYR A 511
GLU A 504
 None
 0.85A 1vm1A-5ukhA:
undetectable		 1vm1A-5ukhA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wab PUTATIVE
BETA-GLUCOSIDASE

(Bifidobacterium
adolescentis) 		no annotation 3 ASP A 532
TYR A 531
GLU A 127
 None
 0.73A 1vm1A-5wabA:
undetectable		 1vm1A-5wabA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnl OXYGEN-EVOLVING
ENHANCER PROTEIN 3

(Pisum sativum) 		no annotation 3 ASP Q  87
TYR Q  83
GLU Q  53
 None
 0.86A 1vm1A-5xnlQ:
undetectable		 1vm1A-5xnlQ:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6k POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Acinetobacter
baumannii) 		no annotation 3 ASP A 272
TYR A 268
GLU A 391
 None
 0.72A 1vm1A-6d6kA:
undetectable		 1vm1A-6d6kA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fd7 -

(-) 		no annotation 3 ASP A 223
TYR A 204
GLU A 229
 None
 0.81A 1vm1A-6fd7A:
undetectable		 1vm1A-6fd7A:
undetectable