SIMILAR PATTERNS OF AMINO ACIDS FOR 1VIF_A_FOLA1_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3r HDLP (HISTONE
DEACETYLASE-LIKE
PROTEIN)

(Aquifex
aeolicus) 		PF00850
(Hist_deacetyl) 		3 GLN A 254
ILE A 165
TYR A 164
 None
 0.68A 1vifA-1c3rA:
undetectable		 1vifA-1c3rA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4k PROTEIN (ORNITHINE
DECARBOXYLASE)

(Lactobacillus
sp. 30A) 		PF01276
(OKR_DC_1)
PF03709
(OKR_DC_1_N)
PF03711
(OKR_DC_1_C) 		3 GLN A 699
ILE A 698
TYR A 660
 None
 0.72A 1vifA-1c4kA:
0.0		 1vifA-1c4kA:
6.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fht U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN A

(Homo sapiens) 		PF00076
(RRM_1) 		3 GLN A  53
ILE A  13
TYR A  12
 None
 0.68A 1vifA-1fhtA:
0.0		 1vifA-1fhtA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g29 MALTOSE TRANSPORT
PROTEIN MALK

(Thermococcus
litoralis) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		3 GLN 1  59
ILE 1  60
TYR 1  61
 MG  1 384 (-4.4A)
None
None
 0.64A 1vifA-1g291:
0.0		 1vifA-1g291:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2i DNA REPAIR PROTEIN
RAD52 HOMOLOG

(Homo sapiens) 		PF04098
(Rad52_Rad22) 		3 GLN A  40
ILE A  39
TYR A  36
 None
 0.71A 1vifA-1h2iA:
0.0		 1vifA-1h2iA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hxj BETA-GLUCOSIDASE

(Zea mays) 		PF00232
(Glyco_hydro_1) 		3 GLN A 447
ILE A 397
TYR A 398
 None
 0.64A 1vifA-1hxjA:
0.0		 1vifA-1hxjA:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ilo CONSERVED
HYPOTHETICAL PROTEIN
MTH895

(Methanothermobacter
thermautotrophicus) 		PF13192
(Thioredoxin_3) 		3 GLN A   5
ILE A   6
TYR A   7
 None
 0.55A 1vifA-1iloA:
0.0		 1vifA-1iloA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jm1 RIESKE IRON-SULFUR
PROTEIN SOXF

(Sulfolobus
acidocaldarius) 		PF00355
(Rieske) 		3 GLN A 120
ILE A 121
TYR A 111
 None
 0.68A 1vifA-1jm1A:
0.0		 1vifA-1jm1A:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js9 COAT PROTEIN

(Brome mosaic
virus) 		PF01318
(Bromo_coat) 		3 GLN A 153
ILE A 154
TYR A 155
 None
 0.61A 1vifA-1js9A:
0.0		 1vifA-1js9A:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k32 TRICORN PROTEASE

(Thermoplasma
acidophilum) 		PF03572
(Peptidase_S41)
PF07676
(PD40)
PF14684
(Tricorn_C1)
PF14685
(Tricorn_PDZ) 		3 GLN A 253
ILE A 254
TYR A 255
 None
 0.72A 1vifA-1k32A:
undetectable		 1vifA-1k32A:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kuu CONSERVED PROTEIN

(Methanothermobacter) 		PF07826
(IMP_cyclohyd) 		3 GLN A 150
ILE A 145
TYR A 144
 None
 0.65A 1vifA-1kuuA:
undetectable		 1vifA-1kuuA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oll NK RECEPTOR

(Homo sapiens) 		no annotation 3 GLN A  20
ILE A  61
TYR A  60
 None
 0.65A 1vifA-1ollA:
undetectable		 1vifA-1ollA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qlz PRION PROTEIN

(Homo sapiens) 		PF00377
(Prion) 		3 GLN A 172
ILE A 215
TYR A 218
 None
 0.74A 1vifA-1qlzA:
undetectable		 1vifA-1qlzA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u05 ORF, CONSERVED
HYPOTHETICAL PROTEIN

(Shigella
flexneri) 		PF02578
(Cu-oxidase_4) 		3 GLN A 185
ILE A 184
TYR A 190
 None
 0.67A 1vifA-1u05A:
undetectable		 1vifA-1u05A:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vzh DESULFOFERRODOXIN

(Desulfarculus
baarsii) 		PF01880
(Desulfoferrodox)
PF06397
(Desulfoferrod_N) 		3 GLN A  78
ILE A  77
TYR A  76
 None
 0.61A 1vifA-1vzhA:
undetectable		 1vifA-1vzhA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yc0 KUNITZ-TYPE PROTEASE
INHIBITOR 1

(Homo sapiens) 		PF00014
(Kunitz_BPTI) 		3 GLN I 273
ILE I 274
TYR I 268
 None
 0.67A 1vifA-1yc0I:
undetectable		 1vifA-1yc0I:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z27 OOKINETE SURFACE
PROTEIN PVS25

(Plasmodium
vivax) 		PF06247
(Plasmod_Pvs28) 		3 GLN A 109
ILE A 108
TYR A 104
 None
 0.76A 1vifA-1z27A:
undetectable		 1vifA-1z27A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zv6 EPB49 PROTEIN

(Homo sapiens) 		PF02209
(VHP)
PF16182
(AbLIM_anchor) 		3 GLN A  12
ILE A  13
TYR A  14
 None
 0.70A 1vifA-1zv6A:
undetectable		 1vifA-1zv6A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btv PROTEIN (VP7 CORE
PROTEIN)

(Bluetongue
virus) 		no annotation 3 GLN P 124
ILE P 251
TYR P 250
 None
 0.71A 1vifA-2btvP:
undetectable		 1vifA-2btvP:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ckb ALPHA, BETA T CELL
RECEPTOR

(Mus musculus) 		PF07686
(V-set)
PF09291
(DUF1968) 		3 GLN A 119
ILE A 118
TYR A 117
 None
 0.70A 1vifA-2ckbA:
undetectable		 1vifA-2ckbA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d62 MULTIPLE
SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN

(Pyrococcus
horikoshii) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		3 GLN A  62
ILE A  63
TYR A  64
 None
 0.74A 1vifA-2d62A:
undetectable		 1vifA-2d62A:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3

(Rattus
norvegicus) 		PF01094
(ANF_receptor)
PF07562
(NCD3G) 		3 GLN A 165
ILE A 166
TYR A 186
 None
 0.72A 1vifA-2e4uA:
undetectable		 1vifA-2e4uA:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ecf DIPEPTIDYL PEPTIDASE
IV

(Stenotrophomonas
maltophilia) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		3 GLN A 407
ILE A 408
TYR A 409
 None
 0.75A 1vifA-2ecfA:
undetectable		 1vifA-2ecfA:
6.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gfi PHYTASE

(Debaryomyces
castellii) 		PF00328
(His_Phos_2) 		3 GLN A  48
ILE A  47
TYR A  46
 None
 0.70A 1vifA-2gfiA:
undetectable		 1vifA-2gfiA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gou OXIDOREDUCTASE,
FMN-BINDING

(Shewanella
oneidensis) 		PF00724
(Oxidored_FMN) 		3 GLN A  60
ILE A  61
TYR A  75
 None
 0.72A 1vifA-2gouA:
undetectable		 1vifA-2gouA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gou OXIDOREDUCTASE,
FMN-BINDING

(Shewanella
oneidensis) 		PF00724
(Oxidored_FMN) 		3 GLN A  60
ILE A  74
TYR A  75
 None
 0.75A 1vifA-2gouA:
undetectable		 1vifA-2gouA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivf ETHYLBENZENE
DEHYDROGENASE
ALPHA-SUBUNIT
ETHYLBENZENE
DEHYDROGENASE
BETA-SUBUNIT

(Aromatoleum
aromaticum;
Aromatoleum
aromaticum) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF13247
(Fer4_11) 		3 GLN B 181
ILE A  67
TYR A  68
 None
 0.67A 1vifA-2ivfB:
undetectable		 1vifA-2ivfB:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kb2 BLRP1

(Klebsiella
pneumoniae) 		PF04940
(BLUF) 		3 GLN A  52
ILE A   9
TYR A  10
 FMN  A 149 ( 3.4A)
None
None
 0.56A 1vifA-2kb2A:
undetectable		 1vifA-2kb2A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lj1 SORBIN AND SH3
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF14604
(SH3_9) 		3 GLN A  18
ILE A  16
TYR A  15
 None
 0.71A 1vifA-2lj1A:
4.3		 1vifA-2lj1A:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p22 SUPPRESSOR PROTEIN
STP22 OF
TEMPERATURE-SENSITIV
E ALPHA-FACTOR
RECEPTOR AND
ARGININE PERMEASE
PROTEIN SRN2

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF09454
(Vps23_core)
PF07200
(Mod_r) 		3 GLN A 289
ILE A 290
TYR C 130
 None
 0.75A 1vifA-2p22A:
undetectable		 1vifA-2p22A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qcz OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR YAET

(Escherichia
coli) 		PF07244
(POTRA) 		3 GLN A 178
ILE A 254
TYR A 255
 None
 0.51A 1vifA-2qczA:
undetectable		 1vifA-2qczA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qip PROTEIN OF UNKNOWN
FUNCTION VPA0982

(Vibrio
parahaemolyticus) 		PF01936
(NYN) 		3 GLN A  81
ILE A  80
TYR A  79
 EDO  A 305 (-4.2A)
EDO  A 301 (-4.0A)
EDO  A 301 ( 4.4A)
 0.63A 1vifA-2qipA:
undetectable		 1vifA-2qipA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9v ATP SYNTHASE SUBUNIT
ALPHA

(Thermotoga
maritima) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		3 GLN A 342
ILE A 343
TYR A 344
 None
 0.63A 1vifA-2r9vA:
undetectable		 1vifA-2r9vA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjz PILO PROTEIN

(Pseudomonas
aeruginosa) 		PF04350
(PilO) 		3 GLN A 138
ILE A 142
TYR A 141
 None
 0.70A 1vifA-2rjzA:
undetectable		 1vifA-2rjzA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rug CYTOPLASMIC
POLYADENYLATION
ELEMENT-BINDING
PROTEIN 3

(Homo sapiens) 		PF16367
(RRM_7) 		3 GLN A 526
ILE A 527
TYR A 512
 None
 0.74A 1vifA-2rugA:
undetectable		 1vifA-2rugA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN

(Homo sapiens) 		PF12330
(Haspin_kinase) 		3 GLN A 718
ILE A 721
TYR A 722
 None
 0.70A 1vifA-2vuwA:
undetectable		 1vifA-2vuwA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wrz L-ARABINOSE-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli) 		PF00532
(Peripla_BP_1) 		3 GLN A 168
ILE A 169
TYR A 170
 None
 0.73A 1vifA-2wrzA:
undetectable		 1vifA-2wrzA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y24 XYLANASE

(Dickeya
chrysanthemi) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		3 GLN A 326
ILE A 325
TYR A  41
 None
 0.74A 1vifA-2y24A:
undetectable		 1vifA-2y24A:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z87 CHONDROITIN SYNTHASE

(Escherichia
coli) 		PF00535
(Glycos_transf_2) 		3 GLN A 517
ILE A 438
TYR A 437
 None
 0.76A 1vifA-2z87A:
undetectable		 1vifA-2z87A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuy YESX PROTEIN

(Bacillus
subtilis) 		PF01839
(FG-GAP) 		3 GLN A   7
ILE A 603
TYR A 602
 None
 0.61A 1vifA-2zuyA:
undetectable		 1vifA-2zuyA:
8.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Aquifex
aeolicus) 		PF01134
(GIDA)
PF13932
(GIDA_assoc) 		3 GLN A 301
ILE A 302
TYR A 253
 None
 0.65A 1vifA-2zxhA:
undetectable		 1vifA-2zxhA:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3crj TRANSCRIPTION
REGULATOR

(Haloarcula
marismortui) 		PF00440
(TetR_N)
PF13977
(TetR_C_6) 		3 GLN A  12
ILE A  16
TYR A  51
 None
 0.75A 1vifA-3crjA:
undetectable		 1vifA-3crjA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzr TRYPTOPHANYL-TRNA
SYNTHETASE

(Entamoeba
histolytica) 		PF00579
(tRNA-synt_1b) 		3 GLN A 115
ILE A 116
TYR A 156
 None
 0.66A 1vifA-3hzrA:
undetectable		 1vifA-3hzrA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i1l HEMAGGLUTININ-ESTERA
SE PROTEIN

(Porcine
torovirus) 		PF02710
(Hema_HEFG)
PF03996
(Hema_esterase) 		3 GLN A 179
ILE A 274
TYR A 275
 NAG  A5155 (-4.0A)
None
None
 0.59A 1vifA-3i1lA:
undetectable		 1vifA-3i1lA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 5

(Homo sapiens) 		PF00443
(UCH)
PF00627
(UBA)
PF02148
(zf-UBP) 		3 GLN A 572
ILE A 573
TYR A 826
 None
 0.69A 1vifA-3ihpA:
undetectable		 1vifA-3ihpA:
6.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j31 C381 TURRET PROTEIN

(Sulfolobus
turreted
icosahedral
virus 1) 		no annotation 3 GLN P 133
ILE P 132
TYR P 131
 None
 0.50A 1vifA-3j31P:
undetectable		 1vifA-3j31P:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcl SPIKE GLYCOPROTEIN

(Murine
coronavirus) 		PF01601
(Corona_S2)
PF09408
(Spike_rec_bind)
PF16451
(Spike_NTD) 		3 GLN A1061
ILE A1058
TYR A1057
 None
 0.73A 1vifA-3jclA:
undetectable		 1vifA-3jclA:
4.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jd5 28S RIBOSOMAL
PROTEIN S22,
MITOCHONDRIAL

(Bos taurus) 		no annotation 3 GLN a 289
ILE a 288
TYR a 348
 None
 0.65A 1vifA-3jd5a:
undetectable		 1vifA-3jd5a:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k44 PURINE-RICH BINDING
PROTEIN-ALPHA,
ISOFORM B

(Drosophila
melanogaster) 		PF04845
(PurA) 		3 GLN A  82
ILE A  83
TYR A  84
 None
 0.68A 1vifA-3k44A:
undetectable		 1vifA-3k44A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lur PUTATIVE BACTERIAL
TRANSCRIPTION
REGULATION PROTEIN

(Staphylococcus
aureus) 		PF06445
(GyrI-like) 		3 GLN A 124
ILE A 120
TYR A 119
 None
EDO  A 161 (-3.6A)
None
 0.68A 1vifA-3lurA:
undetectable		 1vifA-3lurA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ng9 CAPSID PROTEIN

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		3 GLN A 259
ILE A 260
TYR A 276
 None
 0.72A 1vifA-3ng9A:
undetectable		 1vifA-3ng9A:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8o 6-PHOSPHOFRUCTOKINAS
E SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF00365
(PFK) 		3 GLN B 425
ILE B 429
TYR B 409
 None
 0.60A 1vifA-3o8oB:
undetectable		 1vifA-3o8oB:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p1u SUSD HOMOLOG

(Parabacteroides
distasonis) 		PF12741
(SusD-like) 		3 GLN A  67
ILE A  68
TYR A  71
 None
 0.74A 1vifA-3p1uA:
undetectable		 1vifA-3p1uA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rlf MALTOSE/MALTODEXTRIN
IMPORT ATP-BINDING
PROTEIN MALK

(Escherichia
coli) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		3 GLN A 331
ILE A 316
TYR A 329
 None
 0.71A 1vifA-3rlfA:
undetectable		 1vifA-3rlfA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3stb MP18 RNA EDITING
COMPLEX PROTEIN

(Trypanosoma
brucei) 		PF00436
(SSB) 		3 GLN D 119
ILE D 118
TYR D 117
 None
 0.66A 1vifA-3stbD:
undetectable		 1vifA-3stbD:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thu MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME FAMILY
PROTEIN

(Sphingomonas
sp. SKA58) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 GLN A 276
ILE A 275
TYR A 306
 None
 0.76A 1vifA-3thuA:
undetectable		 1vifA-3thuA:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tis PROTEIN YRDA

(Escherichia
coli) 		PF00132
(Hexapep) 		3 GLN A 149
ILE A 150
TYR A 142
 None
 0.69A 1vifA-3tisA:
undetectable		 1vifA-3tisA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0f BETA-KETOACYL
SYNTHASE

(Brucella
abortus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 GLN A 341
ILE A 344
TYR A 345
 None
 0.73A 1vifA-3u0fA:
undetectable		 1vifA-3u0fA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u2k DNA GYRASE SUBUNIT B

(Staphylococcus
aureus) 		PF02518
(HATPase_c) 		3 GLN A 196
ILE A 199
TYR A 227
 None
 0.72A 1vifA-3u2kA:
undetectable		 1vifA-3u2kA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zn6 VP17

(Thermus virus
P23-77) 		no annotation 3 GLN A 263
ILE A 262
TYR A 261
 None
 0.76A 1vifA-3zn6A:
undetectable		 1vifA-3zn6A:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyv AOX3

(Mus musculus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		3 GLN A1027
ILE A1028
TYR A1029
 None
 0.62A 1vifA-3zyvA:
undetectable		 1vifA-3zyvA:
4.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4apl APICAL MEMBRANE
ANTIGEN 1

(Neospora
caninum) 		PF02430
(AMA-1) 		3 GLN A 119
ILE A 118
TYR A 117
 None
 0.74A 1vifA-4aplA:
undetectable		 1vifA-4aplA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		3 GLN A 994
ILE A 991
TYR A1017
 None
 0.70A 1vifA-4bedA:
undetectable		 1vifA-4bedA:
3.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bn2 KINESIN-LIKE PROTEIN
KIF15

(Homo sapiens) 		PF00225
(Kinesin) 		3 GLN A 159
ILE A 160
TYR A 161
 None
 0.74A 1vifA-4bn2A:
undetectable		 1vifA-4bn2A:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fek PUTATIVE DIFLAVIN
FLAVOPROTEIN A 5

(Nostoc sp. PCC
7120) 		no annotation 3 GLN A 168
ILE A 169
TYR A 163
 None
 0.75A 1vifA-4fekA:
undetectable		 1vifA-4fekA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6m ACTIN-LIKE PROTEIN
ARP9

(Saccharomyces
cerevisiae) 		PF00022
(Actin) 		3 GLN B  40
ILE B  41
TYR B  42
 None
 0.76A 1vifA-4i6mB:
undetectable		 1vifA-4i6mB:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4isl KUNITZ-TYPE PROTEASE
INHIBITOR 1

(Homo sapiens) 		PF00014
(Kunitz_BPTI) 		3 GLN B 273
ILE B 274
TYR B 268
 None
 0.76A 1vifA-4islB:
undetectable		 1vifA-4islB:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kml MAJOR PRION PROTEIN

(Homo sapiens) 		PF00377
(Prion) 		3 GLN A 186
ILE A 182
TYR A 162
 None
 0.73A 1vifA-4kmlA:
undetectable		 1vifA-4kmlA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kws D-MANNONATE
DEHYDRATASE

(Chromohalobacter
salexigens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 GLN A 278
ILE A 277
TYR A 308
 None
 0.71A 1vifA-4kwsA:
undetectable		 1vifA-4kwsA:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m88 EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Verminephrobacter
eiseniae) 		PF13458
(Peripla_BP_6) 		3 GLN A 251
ILE A 343
TYR A 354
 None
 0.74A 1vifA-4m88A:
undetectable		 1vifA-4m88A:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4npx PUTATIVE
UNCHARACTERIZED
PROTEIN

(Campylobacter
jejuni) 		PF09442
(DUF2018) 		3 GLN A  71
ILE A  74
TYR A  75
 None
 0.73A 1vifA-4npxA:
undetectable		 1vifA-4npxA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4on3 SORTING NEXIN-10

(Homo sapiens) 		PF00787
(PX) 		3 GLN A  21
ILE A  30
TYR A  29
 NO3  A 304 (-2.8A)
None
None
 0.74A 1vifA-4on3A:
undetectable		 1vifA-4on3A:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE

(Thermococcus
kodakarensis) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		3 GLN A 612
ILE A 611
TYR A 610
 None
 0.62A 1vifA-4qiwA:
undetectable		 1vifA-4qiwA:
5.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r22 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TNRA

(Bacillus
megaterium) 		PF13411
(MerR_1) 		3 GLN B  29
ILE B  30
TYR B  33
 None
 0.76A 1vifA-4r22B:
undetectable		 1vifA-4r22B:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r4e HTH-TYPE
TRANSCRIPTIONAL
REGULATOR GLNR

(Bacillus
subtilis) 		no annotation 3 GLN B  27
ILE B  28
TYR B  31
 None
 0.76A 1vifA-4r4eB:
undetectable		 1vifA-4r4eB:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgg PUTATIVE PHAGE
STRUCTURAL PROTEIN

(Lactococcus
phage 1358) 		no annotation 3 GLN A 166
ILE A 167
TYR A 151
 None
 0.71A 1vifA-4rggA:
undetectable		 1vifA-4rggA:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rus FISH-EGG LECTIN

(Cyprinus carpio) 		PF06462
(Hyd_WA) 		3 GLN A 118
ILE A  98
TYR A  99
 None
None
1PE  A 305 ( 4.0A)
 0.73A 1vifA-4rusA:
undetectable		 1vifA-4rusA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x1v CD2-ASSOCIATED
PROTEIN

(Homo sapiens) 		PF14604
(SH3_9) 		3 GLN A 122
ILE A 120
TYR A 119
 None
 0.68A 1vifA-4x1vA:
4.6		 1vifA-4x1vA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x4w CCA TRNA
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL

(Homo sapiens) 		PF01743
(PolyA_pol)
PF12627
(PolyA_pol_RNAbd) 		3 GLN A 166
ILE A 165
TYR A 169
 None
 0.73A 1vifA-4x4wA:
undetectable		 1vifA-4x4wA:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xru RNL

(Capnocytophaga
gingivalis) 		PF16542
(PNKP_ligase) 		3 GLN B 163
ILE B 162
TYR B 168
 None
 0.74A 1vifA-4xruB:
undetectable		 1vifA-4xruB:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9l PROTEIN ACDH-11,
ISOFORM B

(Caenorhabditis
elegans) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M) 		3 GLN A 227
ILE A 228
TYR A 233
 None
 0.71A 1vifA-4y9lA:
undetectable		 1vifA-4y9lA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7w T-CELL RECEPTOR,
T316 ALPHA CHAIN

(Homo sapiens) 		PF07686
(V-set)
PF09291
(DUF1968) 		3 GLN E 131
ILE E 130
TYR E 129
 None
 0.74A 1vifA-4z7wE:
undetectable		 1vifA-4z7wE:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b2o CRISPR-ASSOCIATED
ENDONUCLEASE CAS9

(Francisella
tularensis) 		no annotation 3 GLN A1211
ILE A1208
TYR A1191
 None
 0.74A 1vifA-5b2oA:
undetectable		 1vifA-5b2oA:
2.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c94 NON-STRUCTURAL
PROTEIN 9

(Avian
coronavirus) 		PF08710
(nsp9) 		3 GLN A  62
ILE A  63
TYR A  64
 None
 0.74A 1vifA-5c94A:
undetectable		 1vifA-5c94A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dl5 MEMBRANE PROTEIN

(Acinetobacter
baumannii) 		PF03573
(OprD) 		3 GLN A 299
ILE A 301
TYR A 302
 None
 0.76A 1vifA-5dl5A:
undetectable		 1vifA-5dl5A:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epd GLYCEROL TRINITRATE
REDUCTASE

(Agrobacterium
tumefaciens) 		PF00724
(Oxidored_FMN) 		3 GLN A  60
ILE A  61
TYR A  75
 None
 0.69A 1vifA-5epdA:
undetectable		 1vifA-5epdA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsb TECTONIN 2

(Laccaria
bicolor) 		no annotation 3 GLN A  43
ILE A  30
TYR A  31
 None
None
6YR  A 300 (-3.8A)
 0.73A 1vifA-5fsbA:
undetectable		 1vifA-5fsbA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsb TECTONIN 2

(Laccaria
bicolor) 		no annotation 3 GLN A  80
ILE A  68
TYR A  69
 None
None
6YR  A 301 (-3.9A)
 0.72A 1vifA-5fsbA:
undetectable		 1vifA-5fsbA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsb TECTONIN 2

(Laccaria
bicolor) 		no annotation 3 GLN A 118
ILE A 105
TYR A 106
 None
None
6YR  A 302 (-3.9A)
 0.76A 1vifA-5fsbA:
undetectable		 1vifA-5fsbA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h4s L-RHAMNOSE-BINDING
LECTIN

(Toxopneustes
pileolus) 		PF02140
(Gal_Lectin) 		3 GLN A  98
ILE A 190
TYR A 189
 None
 0.65A 1vifA-5h4sA:
undetectable		 1vifA-5h4sA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASD

(Escherichia
coli) 		PF09704
(Cas_Cas5d) 		3 GLN J  47
ILE J  46
TYR J 142
 None
A  L   1 ( 4.9A)
A  L   1 ( 3.4A)
 0.68A 1vifA-5h9fJ:
undetectable		 1vifA-5h9fJ:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5it9 RIBOSOMAL PROTEIN
US15

(Kluyveromyces
lactis) 		PF00312
(Ribosomal_S15)
PF08069
(Ribosomal_S13_N) 		3 GLN N  36
ILE N  37
TYR N  40
 None
 0.64A 1vifA-5it9N:
undetectable		 1vifA-5it9N:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2

(Homo sapiens) 		PF01094
(ANF_receptor)
PF07562
(NCD3G) 		3 GLN A 159
ILE A 160
TYR A 180
 None
 0.75A 1vifA-5kznA:
undetectable		 1vifA-5kznA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lwe C-C CHEMOKINE
RECEPTOR TYPE 9

(Homo sapiens) 		PF00001
(7tm_1) 		3 GLN A 150
ILE A 146
TYR A 145
 None
OLA  A 414 ( 4.9A)
OLA  A 405 (-3.9A)
 0.76A 1vifA-5lweA:
undetectable		 1vifA-5lweA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5no7 LYTIC POLYSACCHARIDE
MONOOXYGENASE

(Trametes
cinnabarina) 		no annotation 3 GLN A 174
ILE A 175
TYR A 176
 None
 0.60A 1vifA-5no7A:
undetectable		 1vifA-5no7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uvr PILO PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 3 GLN A 138
ILE A 142
TYR A 141
 None
 0.65A 1vifA-5uvrA:
undetectable		 1vifA-5uvrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xqo PCRGLX PROTEIN

(Penicillium
chrysogenum) 		no annotation 3 GLN A  99
ILE A 100
TYR A 101
 None
 0.59A 1vifA-5xqoA:
undetectable		 1vifA-5xqoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvs VP2

(Aquareovirus C) 		no annotation 3 GLN 2 441
ILE 2 442
TYR 2 554
 None
 0.70A 1vifA-5zvs2:
undetectable		 1vifA-5zvs2:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byo VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S

(Oryctolagus
cuniculus) 		no annotation 3 GLN A 830
ILE A 831
TYR A 834
 None
 0.73A 1vifA-6byoA:
undetectable		 1vifA-6byoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6exv DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Sus scrofa) 		no annotation 3 GLN B  90
ILE B  91
TYR B  92
 None
 0.71A 1vifA-6exvB:
undetectable		 1vifA-6exvB:
undetectable