SIMILAR PATTERNS OF AMINO ACIDS FOR 1VID_A_SAMA301_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dxl DIHYDROLIPOAMIDE
DEHYDROGENASE

(Pisum sativum) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 SER A  60
GLU A 191
TYR A 356
SER A 167
 None
FAD  A 480 ( 4.6A)
FAD  A 480 (-4.7A)
FAD  A 480 (-3.7A)
 1.23A 1vidA-1dxlA:
4.3		 1vidA-1dxlA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eth TRIACYLGLYCEROL
ACYL-HYDROLASE

(Sus scrofa) 		PF00151
(Lipase)
PF01477
(PLAT) 		4 SER A 111
GLU A  84
SER A  88
ASP A 106
 None
 1.45A 1vidA-1ethA:
2.2		 1vidA-1ethA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hcu ALPHA-1,2-MANNOSIDAS
E

(Trichoderma
reesei) 		PF01532
(Glyco_hydro_47) 		4 SER A 180
GLU A 456
SER A 397
ASP A 245
 None
CA  A1495 ( 4.3A)
None
None
 1.09A 1vidA-1hcuA:
0.0		 1vidA-1hcuA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ia7 CELLULASE CEL9M

([Clostridium]
cellulolyticum) 		PF00759
(Glyco_hydro_9) 		4 SER A 208
TYR A 117
SER A  70
ASP A 257
 CA  A1332 (-2.5A)
None
None
EDO  A1337 ( 3.5A)
 1.48A 1vidA-1ia7A:
0.0		 1vidA-1ia7A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpf DIHYDROLIPOAMIDE
DEHYDROGENASE

(Pseudomonas
fluorescens) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 SER A  63
GLU A 194
TYR A 357
SER A 170
 None
None
FAD  A 480 ( 4.7A)
FAD  A 480 ( 3.7A)
 1.24A 1vidA-1lpfA:
2.9		 1vidA-1lpfA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mz5 SIALIDASE

(Trypanosoma
rangeli) 		PF13385
(Laminin_G_3)
PF13859
(BNR_3) 		4 SER A  58
GLU A 358
TYR A 343
ASP A 363
 None
 1.32A 1vidA-1mz5A:
0.0		 1vidA-1mz5A:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uwi BETA-GALACTOSIDASE

(Sulfolobus
solfataricus) 		PF00232
(Glyco_hydro_1) 		4 SER A 265
GLU A 362
TYR A 340
SER A 357
 None
 1.43A 1vidA-1uwiA:
0.0		 1vidA-1uwiA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v59 DIHYDROLIPOAMIDE
DEHYDROGENASE

(Saccharomyces
cerevisiae) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 SER A  59
GLU A 197
TYR A 364
SER A 173
 None
FAD  A 480 ( 4.8A)
FAD  A 480 (-4.4A)
FAD  A 480 (-3.9A)
 1.15A 1vidA-1v59A:
3.2		 1vidA-1v59A:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5v AMINOMETHYLTRANSFERA
SE

(Pyrococcus
horikoshii) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		4 GLU A  57
TYR A 207
SER A 117
ASP A  51
 None
 1.36A 1vidA-1v5vA:
0.0		 1vidA-1v5vA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x44 MYOSIN-BINDING
PROTEIN C, SLOW-TYPE

(Homo sapiens) 		PF07679
(I-set) 		4 SER A  93
GLU A  78
SER A  88
ASP A  16
 None
 1.46A 1vidA-1x44A:
undetectable		 1vidA-1x44A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9j PROBABLE BUTYRATE
KINASE 2

(Thermotoga
maritima) 		PF00871
(Acetate_kinase) 		4 SER A 341
GLU A 334
SER A 106
ASP A 128
 None
 1.12A 1vidA-1x9jA:
undetectable		 1vidA-1x9jA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy8 DIHYDROLIPOYL
DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 SER A  60
GLU A 192
TYR A 359
SER A 168
 None
FAD  A4750 ( 4.3A)
FAD  A4750 (-4.4A)
FAD  A4750 ( 4.0A)
 1.03A 1vidA-1zy8A:
undetectable		 1vidA-1zy8A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bji INOSITOL-1(OR
4)-MONOPHOSPHATASE

(Bos taurus) 		PF00459
(Inositol_P) 		4 SER A1079
GLU A1070
SER A1037
ASP A1274
 None
MG  A2279 ( 2.6A)
None
None
 1.27A 1vidA-2bjiA:
undetectable		 1vidA-2bjiA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eek TRYPSIN-1

(Gadus morhua) 		PF00089
(Trypsin) 		4 SER A 171
GLU A 186
TYR A 184
ASP A 167
 None
 1.25A 1vidA-2eekA:
undetectable		 1vidA-2eekA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ell ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER B

(Homo sapiens) 		PF14580
(LRR_9) 		4 SER A 124
GLU A 161
TYR A 155
ASP A 126
 None
 1.50A 1vidA-2ellA:
undetectable		 1vidA-2ellA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ihm DNA POLYMERASE MU

(Mus musculus) 		PF10391
(DNA_pol_lambd_f)
PF14716
(HHH_8)
PF14791
(DNA_pol_B_thumb)
PF14792
(DNA_pol_B_palm) 		4 SER A 188
GLU A 445
TYR A 141
SER A 178
 None
 1.35A 1vidA-2ihmA:
undetectable		 1vidA-2ihmA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jky HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE

(Saccharomyces
cerevisiae) 		PF00156
(Pribosyltran) 		4 SER A  67
GLU A 194
TYR A 191
SER A  74
 MG  A 302 ( 3.8A)
5GP  A 300 (-2.7A)
5GP  A 300 (-4.6A)
None
 1.18A 1vidA-2jkyA:
3.5		 1vidA-2jkyA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkl SPAC19A8.12 PROTEIN

(Schizosaccharomyces
pombe) 		PF05026
(DCP2) 		4 SER B  16
TYR B  45
SER B   2
ASP B  13
 None
 1.49A 1vidA-2qklB:
undetectable		 1vidA-2qklB:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v91 STRICTOSIDINE
SYNTHASE

(Rauvolfia
serpentina) 		PF03088
(Str_synth) 		4 SER A  58
TYR A 319
SER A 267
ASP A 106
 None
 1.46A 1vidA-2v91A:
undetectable		 1vidA-2v91A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v95 CORTICOSTEROID-BINDI
NG GLOBULIN

(Rattus
norvegicus) 		PF00079
(Serpin) 		4 SER A  89
TYR A  81
SER A  44
ASP A 358
 None
 1.30A 1vidA-2v95A:
undetectable		 1vidA-2v95A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8d PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE 2

(Bacillus
subtilis) 		PF00884
(Sulfatase) 		4 SER A 315
GLU A 359
TYR A 356
ASP A 299
 None
 1.49A 1vidA-2w8dA:
undetectable		 1vidA-2w8dA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wkp NPH1-1, RAS-RELATED
C3 BOTULINUM TOXIN
SUBSTRATE 1

(Avena sativa;
Homo sapiens) 		PF00071
(Ras)
PF13426
(PAS_9) 		4 GLU A 699
TYR A 682
SER A 701
ASP A 664
 None
None
GTP  A1724 (-3.6A)
None
 1.34A 1vidA-2wkpA:
undetectable		 1vidA-2wkpA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xfg ENDOGLUCANASE 1

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9) 		4 SER A 208
GLU A 156
TYR A  69
SER A 217
 CA  A1447 (-4.7A)
None
None
None
 1.29A 1vidA-2xfgA:
undetectable		 1vidA-2xfgA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abs ETHANOLAMINE
AMMONIA-LYASE LIGHT
CHAIN

(Escherichia
coli) 		PF05985
(EutC) 		4 SER B 289
GLU B 210
TYR B 241
ASP B 255
 None
 1.42A 1vidA-3absB:
undetectable		 1vidA-3absB:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3brz TODX

(Pseudomonas
putida) 		PF03349
(Toluene_X) 		4 SER A 280
TYR A   9
SER A 355
ASP A   5
 None
 1.43A 1vidA-3brzA:
undetectable		 1vidA-3brzA:
20.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3bwm CATECHOL
O-METHYLTRANSFERASE

(Homo sapiens) 		PF01596
(Methyltransf_3) 		4 SER A  72
GLU A  90
SER A 119
ASP A 141
 SAM  A 301 (-2.9A)
SAM  A 301 (-2.8A)
SAM  A 301 (-3.1A)
MG  A 300 (-2.4A)
 0.24A 1vidA-3bwmA:
39.2		 1vidA-3bwmA:
81.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c6q SUGAR ABC
TRANSPORTER,
PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Thermotoga
maritima) 		no annotation 4 SER B  95
TYR B 275
SER B 245
ASP B  91
 None
 1.47A 1vidA-3c6qB:
5.5		 1vidA-3c6qB:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fha ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE

(Glutamicibacter
protophormiae) 		PF03644
(Glyco_hydro_85) 		4 SER A  57
GLU A 318
TYR A  83
SER A 307
 None
 1.44A 1vidA-3fhaA:
undetectable		 1vidA-3fhaA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gfv UNCHARACTERIZED ABC
TRANSPORTER
SOLUTE-BINDING
PROTEIN YCLQ

(Bacillus
subtilis) 		PF01497
(Peripla_BP_2) 		4 SER A 245
TYR A 275
SER A 217
ASP A 181
 None
PO4  A 304 (-4.5A)
None
None
 1.36A 1vidA-3gfvA:
undetectable		 1vidA-3gfvA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyb TRANSCRIPTIONAL
REGULATORS
(LACI-FAMILY
TRANSCRIPTIONAL
REGULATORY PROTEIN)

(Corynebacterium
glutamicum) 		PF13377
(Peripla_BP_3) 		4 SER A 240
GLU A 218
TYR A 222
SER A  74
 None
 1.49A 1vidA-3gybA:
4.3		 1vidA-3gybA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icv LIPASE B

(Moesziomyces
antarcticus) 		no annotation 4 SER A 261
TYR A 169
SER A 229
ASP A 221
 None
None
NAG  A 401 (-2.5A)
None
 1.47A 1vidA-3icvA:
undetectable		 1vidA-3icvA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lad DIHYDROLIPOAMIDE
DEHYDROGENASE

(Azotobacter
vinelandii) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 SER A  63
GLU A 194
TYR A 357
SER A 170
 None
None
FAD  A 480 (-4.7A)
FAD  A 480 ( 4.1A)
 1.14A 1vidA-3ladA:
undetectable		 1vidA-3ladA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mtw L-ARGININE
CARBOXYPEPTIDASE
CC2672

(Caulobacter
vibrioides) 		PF01979
(Amidohydro_1) 		4 SER A 274
TYR A 363
SER A 373
ASP A 294
 None
SO4  A   5 (-4.6A)
None
M3R  A 430 (-3.2A)
 1.39A 1vidA-3mtwA:
undetectable		 1vidA-3mtwA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myr HYDROGENASE (NIFE)
SMALL SUBUNIT HYDA
NICKEL-DEPENDENT
HYDROGENASE LARGE
SUBUNIT

(Allochromatium
vinosum;
Allochromatium
vinosum) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C)
PF00374
(NiFeSe_Hases) 		4 SER A 204
GLU A 208
SER B1230
ASP A 206
 None
 1.34A 1vidA-3myrA:
undetectable		 1vidA-3myrA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nz4 PHENYLALANINE
AMMONIA-LYASE

(Taxus
canadensis) 		PF00221
(Lyase_aromatic) 		4 GLU A 404
TYR A 405
SER A 415
ASP A 430
 None
 1.49A 1vidA-3nz4A:
undetectable		 1vidA-3nz4A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q48 CHAPERONE CUPB2

(Pseudomonas
aeruginosa) 		PF00345
(PapD_N)
PF02753
(PapD_C) 		4 GLU A 111
TYR A 184
SER A 151
ASP A 109
 None
 1.49A 1vidA-3q48A:
undetectable		 1vidA-3q48A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qpf PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
pneumoniae) 		PF06824
(Glyco_hydro_125) 		4 SER A 348
GLU A 288
SER A 212
ASP A 219
 None
 1.38A 1vidA-3qpfA:
undetectable		 1vidA-3qpfA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rhy N(G),N(G)-DIMETHYLAR
GININE
DIMETHYLAMINOHYDROLA
SE

(Pseudomonas
aeruginosa) 		PF02274
(Amidinotransf) 		4 SER A  72
TYR A 169
SER A 153
ASP A 123
 None
 1.33A 1vidA-3rhyA:
undetectable		 1vidA-3rhyA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t7v METHYLORNITHINE
SYNTHASE PYLB

(Methanosarcina
barkeri) 		PF04055
(Radical_SAM) 		4 SER A 222
GLU A 171
TYR A 169
SER A  76
 None
SAM  A 992 (-2.8A)
SAM  A 992 ( 4.6A)
None
 1.44A 1vidA-3t7vA:
undetectable		 1vidA-3t7vA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3urh DIHYDROLIPOYL
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 SER A  56
GLU A 189
TYR A 354
SER A 165
 None
FAD  A 500 ( 4.5A)
FAD  A 500 (-4.5A)
FAD  A 500 (-3.5A)
 1.11A 1vidA-3urhA:
undetectable		 1vidA-3urhA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3us8 ISOCITRATE
DEHYDROGENASE [NADP]

(Sinorhizobium
meliloti) 		PF00180
(Iso_dh) 		4 GLU A  12
TYR A  41
SER A 330
ASP A  28
 None
 1.06A 1vidA-3us8A:
undetectable		 1vidA-3us8A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va6 TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE

(Bacteroides
thetaiotaomicron) 		PF07494
(Reg_prop)
PF07495
(Y_Y_Y) 		4 SER A  49
TYR A  93
SER A 263
ASP A 324
 None
 1.38A 1vidA-3va6A:
undetectable		 1vidA-3va6A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wcy INTERFERON
ALPHA/BETA RECEPTOR
1

(Mus musculus) 		PF01108
(Tissue_fac)
PF09294
(Interfer-bind) 		4 SER A 245
GLU A 106
SER A 103
ASP A 126
 None
 1.30A 1vidA-3wcyA:
undetectable		 1vidA-3wcyA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2l TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE/RESPONSE

(Bacteroides
thetaiotaomicron) 		PF07494
(Reg_prop)
PF07495
(Y_Y_Y) 		4 SER A  47
GLU A 137
TYR A 180
ASP A  49
 None
 1.17A 1vidA-4a2lA:
undetectable		 1vidA-4a2lA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4doe 1,4-BETA-GLUCANASE

(Caldicellulosiruptor
bescii) 		PF00759
(Glyco_hydro_9) 		4 SER A 229
GLU A 177
TYR A  90
SER A 238
 EDO  A 522 (-3.3A)
None
None
None
 1.26A 1vidA-4doeA:
undetectable		 1vidA-4doeA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dqv PROBABLE PEPTIDE
SYNTHETASE NRP
(PEPTIDE SYNTHASE)

(Mycobacterium
tuberculosis) 		PF07993
(NAD_binding_4) 		4 GLU A 236
TYR A 190
SER A 215
ASP A 195
 None
 1.27A 1vidA-4dqvA:
6.8		 1vidA-4dqvA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1

(Caenorhabditis
elegans) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 GLU A 297
TYR A 296
SER A 283
ASP A1166
 None
 1.49A 1vidA-4f4cA:
undetectable		 1vidA-4f4cA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1

(Caenorhabditis
elegans) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 GLU A 297
TYR A 296
SER A 284
ASP A1166
 None
 1.23A 1vidA-4f4cA:
undetectable		 1vidA-4f4cA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hcx ISOCITRATE
DEHYDROGENASE [NADP]

(Mycobacterium
tuberculosis) 		PF00180
(Iso_dh) 		4 GLU A  15
TYR A  44
SER A 335
ASP A  31
 None
 1.11A 1vidA-4hcxA:
undetectable		 1vidA-4hcxA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hum MULTIDRUG EFFLUX
PROTEIN
PROTEIN B

(Neisseria
gonorrhoeae;
Escherichia
coli) 		PF01554
(MatE)
PF00041
(fn3) 		4 SER B  55
GLU B   9
SER A 460
ASP B  23
 None
 1.18A 1vidA-4humB:
undetectable		 1vidA-4humB:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcm CYCLODEXTRIN
GLUCANOTRANSFERASE

([Bacillus]
clarkii) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		4 SER A 205
TYR A 165
SER A 139
ASP A 101
 None
 0.95A 1vidA-4jcmA:
undetectable		 1vidA-4jcmA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oue PUTATIVE LIPOPROTEIN

(Bacteroides
thetaiotaomicron) 		PF00754
(F5_F8_type_C)
PF01120
(Alpha_L_fucos) 		4 SER A 114
TYR A 110
SER A 156
ASP A 112
 None
 1.37A 1vidA-4oueA:
undetectable		 1vidA-4oueA:
19.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p58 CATECHOL
O-METHYLTRANSFERASE

(Mus musculus) 		PF01596
(Methyltransf_3) 		5 SER A 115
GLU A 133
TYR A 138
SER A 162
ASP A 184
 None
2F6  A 301 (-2.7A)
None
2F6  A 301 (-3.2A)
None
 0.70A 1vidA-4p58A:
33.0		 1vidA-4p58A:
97.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0v FE-HYDROGENASE

(Chlamydomonas
reinhardtii) 		PF02256
(Fe_hyd_SSU)
PF02906
(Fe_hyd_lg_C) 		4 SER A 230
GLU A 178
TYR A 485
SER A 180
 None
 1.32A 1vidA-4r0vA:
undetectable		 1vidA-4r0vA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rl4 GTP CYCLOHYDROLASE-2

(Helicobacter
pylori) 		PF00925
(GTP_cyclohydro2) 		4 SER A  63
GLU A  92
SER A  53
ASP A  67
 None
None
PPV  A 201 ( 4.8A)
None
 1.45A 1vidA-4rl4A:
undetectable		 1vidA-4rl4A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zv7 LIPASE B

(Moesziomyces
antarcticus) 		no annotation 4 SER A 227
TYR A 135
SER A 195
ASP A 187
 None
 1.42A 1vidA-4zv7A:
undetectable		 1vidA-4zv7A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c8s GUANINE-N7
METHYLTRANSFERASE

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF06471
(NSP11) 		4 SER B 220
TYR B 224
SER B 171
ASP B 234
 None
 1.42A 1vidA-5c8sB:
undetectable		 1vidA-5c8sB:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dl6 PUTATIVE PORIN FOR
VANILLATE
TRAFFICKING (VANP)

(Acinetobacter
baumannii) 		PF03573
(OprD) 		4 GLU A 345
TYR A 371
SER A 305
ASP A 290
 None
 1.44A 1vidA-5dl6A:
undetectable		 1vidA-5dl6A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ftz CHITIN BINDING
PROTEIN

(Streptomyces
lividans) 		PF03067
(LPMO_10) 		4 SER A 143
TYR A 128
SER A  79
ASP A  74
 None
 1.40A 1vidA-5ftzA:
undetectable		 1vidA-5ftzA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5huu ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
[UDP-FORMING]

(Candida
albicans) 		PF00982
(Glyco_transf_20) 		4 SER A 375
TYR A 283
SER A 332
ASP A 279
 None
 1.30A 1vidA-5huuA:
3.1		 1vidA-5huuA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzh RAS-RELATED C3
BOTULINUM TOXIN
SUBSTRATE
1,NPH1-1,RAS-RELATED
C3 BOTULINUM TOXIN
SUBSTRATE 1

(Avena sativa;
Homo sapiens) 		PF00071
(Ras)
PF13426
(PAS_9) 		4 GLU A 305
TYR A 288
SER A 307
ASP A 270
 None
None
GTP  A 401 (-3.5A)
None
 1.38A 1vidA-5hzhA:
undetectable		 1vidA-5hzhA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tr3 DIHYDROLIPOYL
DEHYDROGENASE

(Pseudomonas
putida) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 SER A  64
GLU A 195
TYR A 358
SER A 171
 None
FAD  A 501 ( 4.6A)
FAD  A 501 (-4.1A)
FAD  A 501 (-3.5A)
 1.07A 1vidA-5tr3A:
undetectable		 1vidA-5tr3A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5us1 AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE

(Providencia
stuartii) 		PF13673
(Acetyltransf_10) 		4 SER A 116
GLU A  79
TYR A  77
SER A  34
 8MM  A 201 (-3.7A)
8MM  A 201 (-4.5A)
None
None
 1.47A 1vidA-5us1A:
undetectable		 1vidA-5us1A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdr RAS PROTEIN

(Choanoflagellida) 		PF00071
(Ras) 		4 SER A  89
GLU A 144
SER A 146
ASP A  85
 None
None
GNP  A 203 (-3.5A)
None
 1.36A 1vidA-5wdrA:
3.0		 1vidA-5wdrA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4g AMBP3

(Fischerella
ambigua) 		no annotation 4 GLU A 207
TYR A 168
SER A 287
ASP A 277
 None
 1.08A 1vidA-5y4gA:
undetectable		 1vidA-5y4gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yyl -

(-) 		no annotation 4 SER A 186
GLU A 211
TYR A 233
SER A 228
 None
 1.43A 1vidA-5yylA:
undetectable		 1vidA-5yylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bz0 DIHYDROLIPOYL
DEHYDROGENASE

(Acinetobacter
baumannii) 		no annotation 4 SER A  63
GLU A 194
TYR A 357
SER A 170
 None
FAD  A 501 ( 4.5A)
FAD  A 501 (-4.3A)
CL  A 502 ( 2.9A)
 1.13A 1vidA-6bz0A:
undetectable		 1vidA-6bz0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eua ANGIOPOIETIN-RELATED
PROTEIN 3

(Homo sapiens) 		no annotation 4 SER A 280
GLU A 346
TYR A 344
SER A 348
 None
 1.41A 1vidA-6euaA:
undetectable		 1vidA-6euaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza A
virus) 		no annotation 4 SER B 443
GLU B 491
SER B 482
ASP B 445
 None
 1.39A 1vidA-6evjB:
undetectable		 1vidA-6evjB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gct NEUTRAL AMINO ACID
TRANSPORTER B(0)

(Homo sapiens) 		no annotation 4 SER A 454
GLU A 291
SER A  87
ASP A 451
 None
 1.31A 1vidA-6gctA:
undetectable		 1vidA-6gctA:
undetectable