SIMILAR PATTERNS OF AMINO ACIDS FOR 1VID_A_SAMA301
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pc3 | PHOSPHATE-BINDINGPROTEIN 1 (Mycobacteriumtuberculosis) |
PF12849(PBP_like_2) | 5 | VAL A 158GLU A 217GLY A 214ASN A 206GLN A 232 | None | 1.45A | 1vidA-1pc3A:undetectable | 1vidA-1pc3A:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sus | CAFFEOYL-COAO-METHYLTRANSFERASE (Medicago sativa) |
PF01596(Methyltransf_3) | 6 | MET A 61GLU A 85GLY A 87TYR A 89TYR A 92ASN A 113 | SPF A 401 (-4.1A)SAH A 301 (-4.1A)SAH A 301 (-3.4A)SAH A 301 (-4.7A)NoneNone | 0.78A | 1vidA-1susA:21.3 | 1vidA-1susA:25.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bku | IMPORTIN BETA-1SUBUNIT (Saccharomycescerevisiae) |
PF03810(IBN_N)PF13513(HEAT_EZ) | 5 | MET B 682ASN B 683VAL B 684TYR B 720MET B 725 | None | 1.42A | 1vidA-2bkuB:undetectable | 1vidA-2bkuB:14.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h1y | MALONYL COENZYMEA-ACYL CARRIERPROTEIN TRANSACYLASE (Helicobacterpylori) |
PF00698(Acyl_transf_1) | 5 | VAL A 96GLY A 9TYR A 65GLN A 163HIS A 91 | None | 1.25A | 1vidA-2h1yA:undetectable | 1vidA-2h1yA:21.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nxf | PUTATIVE DIMETALPHOSPHATASE (Danio rerio) |
PF00149(Metallophos) | 5 | VAL A 14GLU A 98GLY A 95ASN A 198GLN A 205 | None | 1.14A | 1vidA-2nxfA:undetectable | 1vidA-2nxfA:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3akf | PUTATIVE SECRETEDALPHAL-ARABINOFURANOSIDASE II (Streptomycesavermitilis) |
PF04616(Glyco_hydro_43)PF05270(AbfB) | 5 | ASN A 422GLU A 419GLY A 425TYR A 423TYR A 421 | None | 1.43A | 1vidA-3akfA:undetectable | 1vidA-3akfA:19.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b8y | ENDO-PECTATE LYASE (Dickeyachrysanthemi) |
PF03211(Pectate_lyase) | 5 | ASN A 274VAL A 273GLY A 209TYR A 34MET A 25 | None | 1.46A | 1vidA-3b8yA:undetectable | 1vidA-3b8yA:21.14 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3bwm | CATECHOLO-METHYLTRANSFERASE (Homo sapiens) |
PF01596(Methyltransf_3) | 11 | MET A 40ASN A 41VAL A 42GLU A 64GLY A 66TYR A 68TYR A 71ASN A 92GLN A 120HIS A 142TRP A 143 | SAM A 301 (-3.7A)SAM A 301 (-4.7A)SAM A 301 ( 3.7A)SAM A 301 ( 4.1A)SAM A 301 (-3.2A)SAM A 301 (-4.7A)NoneNoneSAM A 301 (-3.6A)SAM A 301 ( 4.9A)SAM A 301 ( 3.4A) | 0.26A | 1vidA-3bwmA:39.2 | 1vidA-3bwmA:81.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d8k | PROTEIN PHOSPHATASE2C (Toxoplasmagondii) |
PF00481(PP2C) | 5 | VAL A 187GLU A 114GLY A 115ASN A 150GLN A 143 | None | 1.43A | 1vidA-3d8kA:undetectable | 1vidA-3d8kA:19.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fsg | ALPHA/BETASUPERFAMILYHYDROLASE (Oenococcus oeni) |
PF12697(Abhydrolase_6) | 5 | VAL A 219GLY A 243TYR A 221ASN A 240HIS A 133 | None | 1.47A | 1vidA-3fsgA:3.4 | 1vidA-3fsgA:23.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mzn | GLUCARATEDEHYDRATASE (Chromohalobactersalexigens) |
PF13378(MR_MLE_C) | 5 | VAL A 242GLU A 262GLY A 260ASN A 233GLN A 293 | None | 1.34A | 1vidA-3mznA:undetectable | 1vidA-3mznA:20.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ntv | MW1564 PROTEIN (Staphylococcusaureus) |
PF01596(Methyltransf_3) | 6 | VAL A 55GLU A 77GLY A 79TYR A 84ASN A 104GLN A 154 | SO4 A 233 (-4.2A)SO4 A 233 (-4.0A)NoneSO4 A 233 (-4.9A)NoneNone | 1.14A | 1vidA-3ntvA:21.4 | 1vidA-3ntvA:22.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bz7 | HISTONE DEACETYLASE8 (Schistosomamansoni) |
PF00850(Hist_deacetyl) | 5 | ASN A 98GLY A 150TYR A 99GLN A 281HIS A 142 | NoneGOL A 800 ( 3.5A)B3N A 700 ( 3.8A)NoneB3N A 700 (-3.7A) | 1.48A | 1vidA-4bz7A:3.7 | 1vidA-4bz7A:20.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c2t | DNA HELICASE II (Deinococcusradiodurans) |
PF00580(UvrD-helicase)PF13361(UvrD_C) | 5 | VAL A 369GLU A 336GLY A 585TYR A 361GLN A 588 | None | 1.38A | 1vidA-4c2tA:1.9 | 1vidA-4c2tA:13.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c30 | DNA HELICASE II (Deinococcusradiodurans) |
PF00580(UvrD-helicase)PF13361(UvrD_C) | 5 | VAL A 369GLU A 336GLY A 585TYR A 361GLN A 588 | None | 1.34A | 1vidA-4c30A:4.2 | 1vidA-4c30A:15.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g8t | GLUCARATEDEHYDRATASE (Actinobacillussuccinogenes) |
PF13378(MR_MLE_C) | 5 | VAL A 242GLU A 262GLY A 260ASN A 233GLN A 293 | NoneNoneNone NA A 502 (-3.7A)None | 1.14A | 1vidA-4g8tA:undetectable | 1vidA-4g8tA:20.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gxr | MALONYL COASYNTHETASE,BENZOATE-COA LIGASECHIMERIC PROTEIN (Rhodopseudomonaspalustris;Paraburkholderiaxenovorans) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 5 | ASN A 408VAL A 409GLU A 439GLY A 438HIS A 434 | NoneMLY A 470 ( 4.9A)NoneNoneNone | 1.48A | 1vidA-4gxrA:2.4 | 1vidA-4gxrA:19.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ig7 | UBIQUITIN C-TERMINALHYDROLASE 37 (Trichinellaspiralis) |
PF01088(Peptidase_C12) | 5 | VAL A 168GLY A 48TYR A 173GLN A 225HIS A 47 | None | 1.20A | 1vidA-4ig7A:undetectable | 1vidA-4ig7A:20.18 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4p58 | CATECHOLO-METHYLTRANSFERASE (Mus musculus) |
PF01596(Methyltransf_3) | 6 | GLU A 107GLY A 109TYR A 114ASN A 135GLN A 163HIS A 185 | None2F6 A 301 (-3.6A)NoneNone2F6 A 301 (-3.8A)None | 0.44A | 1vidA-4p58A:33.0 | 1vidA-4p58A:97.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kva | CAFFEOYL-COAO-METHYLTRANSFERASE (Sorghum bicolor) |
PF01596(Methyltransf_3) | 5 | GLU A 99GLY A 101TYR A 103TYR A 106ASN A 127 | SAM A 301 ( 4.0A)SAM A 301 (-3.4A)SAM A 301 (-4.8A)NoneNone | 0.60A | 1vidA-5kvaA:21.3 | 1vidA-5kvaA:24.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kva | CAFFEOYL-COAO-METHYLTRANSFERASE (Sorghum bicolor) |
PF01596(Methyltransf_3) | 5 | MET A 75GLU A 99GLY A 101TYR A 103ASN A 127 | SAM A 301 (-3.8A)SAM A 301 ( 4.0A)SAM A 301 (-3.4A)SAM A 301 (-4.8A)None | 0.58A | 1vidA-5kvaA:21.3 | 1vidA-5kvaA:24.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n4l | CERULOPLASMIN (Rattusnorvegicus) |
no annotation | 5 | ASN A 605GLU A 424GLY A 608MET A 611HIS A 425 | None | 1.29A | 1vidA-5n4lA:undetectable | 1vidA-5n4lA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fik | POLYKETIDE SYNTHASE (Cercosporanicotianae) |
no annotation | 5 | ASN A 730VAL A 731GLY A 689GLN A 664HIS A 688 | None | 1.48A | 1vidA-6fikA:undetectable | 1vidA-6fikA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dxl | DIHYDROLIPOAMIDEDEHYDROGENASE (Pisum sativum) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 4 | SER A 60GLU A 191TYR A 356SER A 167 | NoneFAD A 480 ( 4.6A)FAD A 480 (-4.7A)FAD A 480 (-3.7A) | 1.23A | 1vidA-1dxlA:4.3 | 1vidA-1dxlA:19.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1eth | TRIACYLGLYCEROLACYL-HYDROLASE (Sus scrofa) |
PF00151(Lipase)PF01477(PLAT) | 4 | SER A 111GLU A 84SER A 88ASP A 106 | None | 1.45A | 1vidA-1ethA:2.2 | 1vidA-1ethA:20.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hcu | ALPHA-1,2-MANNOSIDASE (Trichodermareesei) |
PF01532(Glyco_hydro_47) | 4 | SER A 180GLU A 456SER A 397ASP A 245 | None CA A1495 ( 4.3A)NoneNone | 1.09A | 1vidA-1hcuA:0.0 | 1vidA-1hcuA:21.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ia7 | CELLULASE CEL9M ([Clostridium]cellulolyticum) |
PF00759(Glyco_hydro_9) | 4 | SER A 208TYR A 117SER A 70ASP A 257 | CA A1332 (-2.5A)NoneNoneEDO A1337 ( 3.5A) | 1.48A | 1vidA-1ia7A:0.0 | 1vidA-1ia7A:20.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lpf | DIHYDROLIPOAMIDEDEHYDROGENASE (Pseudomonasfluorescens) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 4 | SER A 63GLU A 194TYR A 357SER A 170 | NoneNoneFAD A 480 ( 4.7A)FAD A 480 ( 3.7A) | 1.24A | 1vidA-1lpfA:2.9 | 1vidA-1lpfA:17.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mz5 | SIALIDASE (Trypanosomarangeli) |
PF13385(Laminin_G_3)PF13859(BNR_3) | 4 | SER A 58GLU A 358TYR A 343ASP A 363 | None | 1.32A | 1vidA-1mz5A:0.0 | 1vidA-1mz5A:16.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uwi | BETA-GALACTOSIDASE (Sulfolobussolfataricus) |
PF00232(Glyco_hydro_1) | 4 | SER A 265GLU A 362TYR A 340SER A 357 | None | 1.43A | 1vidA-1uwiA:0.0 | 1vidA-1uwiA:15.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v59 | DIHYDROLIPOAMIDEDEHYDROGENASE (Saccharomycescerevisiae) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 4 | SER A 59GLU A 197TYR A 364SER A 173 | NoneFAD A 480 ( 4.8A)FAD A 480 (-4.4A)FAD A 480 (-3.9A) | 1.15A | 1vidA-1v59A:3.2 | 1vidA-1v59A:17.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v5v | AMINOMETHYLTRANSFERASE (Pyrococcushorikoshii) |
PF01571(GCV_T)PF08669(GCV_T_C) | 4 | GLU A 57TYR A 207SER A 117ASP A 51 | None | 1.36A | 1vidA-1v5vA:0.0 | 1vidA-1v5vA:19.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x44 | MYOSIN-BINDINGPROTEIN C, SLOW-TYPE (Homo sapiens) |
PF07679(I-set) | 4 | SER A 93GLU A 78SER A 88ASP A 16 | None | 1.46A | 1vidA-1x44A:undetectable | 1vidA-1x44A:20.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x9j | PROBABLE BUTYRATEKINASE 2 (Thermotogamaritima) |
PF00871(Acetate_kinase) | 4 | SER A 341GLU A 334SER A 106ASP A 128 | None | 1.12A | 1vidA-1x9jA:undetectable | 1vidA-1x9jA:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zy8 | DIHYDROLIPOYLDEHYDROGENASE,MITOCHONDRIAL (Homo sapiens) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 4 | SER A 60GLU A 192TYR A 359SER A 168 | NoneFAD A4750 ( 4.3A)FAD A4750 (-4.4A)FAD A4750 ( 4.0A) | 1.03A | 1vidA-1zy8A:undetectable | 1vidA-1zy8A:17.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bji | INOSITOL-1(OR4)-MONOPHOSPHATASE (Bos taurus) |
PF00459(Inositol_P) | 4 | SER A1079GLU A1070SER A1037ASP A1274 | None MG A2279 ( 2.6A)NoneNone | 1.27A | 1vidA-2bjiA:undetectable | 1vidA-2bjiA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eek | TRYPSIN-1 (Gadus morhua) |
PF00089(Trypsin) | 4 | SER A 171GLU A 186TYR A 184ASP A 167 | None | 1.25A | 1vidA-2eekA:undetectable | 1vidA-2eekA:19.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ell | ACIDIC LEUCINE-RICHNUCLEARPHOSPHOPROTEIN 32FAMILY MEMBER B (Homo sapiens) |
PF14580(LRR_9) | 4 | SER A 124GLU A 161TYR A 155ASP A 126 | None | 1.50A | 1vidA-2ellA:undetectable | 1vidA-2ellA:23.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ihm | DNA POLYMERASE MU (Mus musculus) |
PF10391(DNA_pol_lambd_f)PF14716(HHH_8)PF14791(DNA_pol_B_thumb)PF14792(DNA_pol_B_palm) | 4 | SER A 188GLU A 445TYR A 141SER A 178 | None | 1.35A | 1vidA-2ihmA:undetectable | 1vidA-2ihmA:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jky | HYPOXANTHINE-GUANINEPHOSPHORIBOSYLTRANSFERASE (Saccharomycescerevisiae) |
PF00156(Pribosyltran) | 4 | SER A 67GLU A 194TYR A 191SER A 74 | MG A 302 ( 3.8A)5GP A 300 (-2.7A)5GP A 300 (-4.6A)None | 1.18A | 1vidA-2jkyA:3.5 | 1vidA-2jkyA:22.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qkl | SPAC19A8.12 PROTEIN (Schizosaccharomycespombe) |
PF05026(DCP2) | 4 | SER B 16TYR B 45SER B 2ASP B 13 | None | 1.49A | 1vidA-2qklB:undetectable | 1vidA-2qklB:18.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v91 | STRICTOSIDINESYNTHASE (Rauvolfiaserpentina) |
PF03088(Str_synth) | 4 | SER A 58TYR A 319SER A 267ASP A 106 | None | 1.46A | 1vidA-2v91A:undetectable | 1vidA-2v91A:21.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v95 | CORTICOSTEROID-BINDING GLOBULIN (Rattusnorvegicus) |
PF00079(Serpin) | 4 | SER A 89TYR A 81SER A 44ASP A 358 | None | 1.30A | 1vidA-2v95A:undetectable | 1vidA-2v95A:19.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w8d | PROCESSED GLYCEROLPHOSPHATELIPOTEICHOIC ACIDSYNTHASE 2 (Bacillussubtilis) |
PF00884(Sulfatase) | 4 | SER A 315GLU A 359TYR A 356ASP A 299 | None | 1.49A | 1vidA-2w8dA:undetectable | 1vidA-2w8dA:19.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wkp | NPH1-1, RAS-RELATEDC3 BOTULINUM TOXINSUBSTRATE 1 (Avena sativa;Homo sapiens) |
PF00071(Ras)PF13426(PAS_9) | 4 | GLU A 699TYR A 682SER A 701ASP A 664 | NoneNoneGTP A1724 (-3.6A)None | 1.34A | 1vidA-2wkpA:undetectable | 1vidA-2wkpA:21.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xfg | ENDOGLUCANASE 1 (Ruminiclostridiumthermocellum) |
PF00759(Glyco_hydro_9) | 4 | SER A 208GLU A 156TYR A 69SER A 217 | CA A1447 (-4.7A)NoneNoneNone | 1.29A | 1vidA-2xfgA:undetectable | 1vidA-2xfgA:18.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3abs | ETHANOLAMINEAMMONIA-LYASE LIGHTCHAIN (Escherichiacoli) |
PF05985(EutC) | 4 | SER B 289GLU B 210TYR B 241ASP B 255 | None | 1.42A | 1vidA-3absB:undetectable | 1vidA-3absB:21.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3brz | TODX (Pseudomonasputida) |
PF03349(Toluene_X) | 4 | SER A 280TYR A 9SER A 355ASP A 5 | None | 1.43A | 1vidA-3brzA:undetectable | 1vidA-3brzA:20.99 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3bwm | CATECHOLO-METHYLTRANSFERASE (Homo sapiens) |
PF01596(Methyltransf_3) | 4 | SER A 72GLU A 90SER A 119ASP A 141 | SAM A 301 (-2.9A)SAM A 301 (-2.8A)SAM A 301 (-3.1A) MG A 300 (-2.4A) | 0.24A | 1vidA-3bwmA:39.2 | 1vidA-3bwmA:81.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c6q | SUGAR ABCTRANSPORTER,PERIPLASMICSUGAR-BINDINGPROTEIN (Thermotogamaritima) |
no annotation | 4 | SER B 95TYR B 275SER B 245ASP B 91 | None | 1.47A | 1vidA-3c6qB:5.5 | 1vidA-3c6qB:21.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fha | ENDO-BETA-N-ACETYLGLUCOSAMINIDASE (Glutamicibacterprotophormiae) |
PF03644(Glyco_hydro_85) | 4 | SER A 57GLU A 318TYR A 83SER A 307 | None | 1.44A | 1vidA-3fhaA:undetectable | 1vidA-3fhaA:17.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gfv | UNCHARACTERIZED ABCTRANSPORTERSOLUTE-BINDINGPROTEIN YCLQ (Bacillussubtilis) |
PF01497(Peripla_BP_2) | 4 | SER A 245TYR A 275SER A 217ASP A 181 | NonePO4 A 304 (-4.5A)NoneNone | 1.36A | 1vidA-3gfvA:undetectable | 1vidA-3gfvA:21.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gyb | TRANSCRIPTIONALREGULATORS(LACI-FAMILYTRANSCRIPTIONALREGULATORY PROTEIN) (Corynebacteriumglutamicum) |
PF13377(Peripla_BP_3) | 4 | SER A 240GLU A 218TYR A 222SER A 74 | None | 1.49A | 1vidA-3gybA:4.3 | 1vidA-3gybA:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3icv | LIPASE B (Moesziomycesantarcticus) |
no annotation | 4 | SER A 261TYR A 169SER A 229ASP A 221 | NoneNoneNAG A 401 (-2.5A)None | 1.47A | 1vidA-3icvA:undetectable | 1vidA-3icvA:22.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lad | DIHYDROLIPOAMIDEDEHYDROGENASE (Azotobactervinelandii) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 4 | SER A 63GLU A 194TYR A 357SER A 170 | NoneNoneFAD A 480 (-4.7A)FAD A 480 ( 4.1A) | 1.14A | 1vidA-3ladA:undetectable | 1vidA-3ladA:18.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mtw | L-ARGININECARBOXYPEPTIDASECC2672 (Caulobactervibrioides) |
PF01979(Amidohydro_1) | 4 | SER A 274TYR A 363SER A 373ASP A 294 | NoneSO4 A 5 (-4.6A)NoneM3R A 430 (-3.2A) | 1.39A | 1vidA-3mtwA:undetectable | 1vidA-3mtwA:20.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3myr | HYDROGENASE (NIFE)SMALL SUBUNIT HYDANICKEL-DEPENDENTHYDROGENASE LARGESUBUNIT (Allochromatiumvinosum;Allochromatiumvinosum) |
PF01058(Oxidored_q6)PF14720(NiFe_hyd_SSU_C)PF00374(NiFeSe_Hases) | 4 | SER A 204GLU A 208SER B1230ASP A 206 | None | 1.34A | 1vidA-3myrA:undetectable | 1vidA-3myrA:21.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nz4 | PHENYLALANINEAMMONIA-LYASE (Taxuscanadensis) |
PF00221(Lyase_aromatic) | 4 | GLU A 404TYR A 405SER A 415ASP A 430 | None | 1.49A | 1vidA-3nz4A:undetectable | 1vidA-3nz4A:15.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q48 | CHAPERONE CUPB2 (Pseudomonasaeruginosa) |
PF00345(PapD_N)PF02753(PapD_C) | 4 | GLU A 111TYR A 184SER A 151ASP A 109 | None | 1.49A | 1vidA-3q48A:undetectable | 1vidA-3q48A:19.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qpf | PUTATIVEUNCHARACTERIZEDPROTEIN (Streptococcuspneumoniae) |
PF06824(Glyco_hydro_125) | 4 | SER A 348GLU A 288SER A 212ASP A 219 | None | 1.38A | 1vidA-3qpfA:undetectable | 1vidA-3qpfA:20.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rhy | N(G),N(G)-DIMETHYLARGININEDIMETHYLAMINOHYDROLASE (Pseudomonasaeruginosa) |
PF02274(Amidinotransf) | 4 | SER A 72TYR A 169SER A 153ASP A 123 | None | 1.33A | 1vidA-3rhyA:undetectable | 1vidA-3rhyA:22.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t7v | METHYLORNITHINESYNTHASE PYLB (Methanosarcinabarkeri) |
PF04055(Radical_SAM) | 4 | SER A 222GLU A 171TYR A 169SER A 76 | NoneSAM A 992 (-2.8A)SAM A 992 ( 4.6A)None | 1.44A | 1vidA-3t7vA:undetectable | 1vidA-3t7vA:22.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3urh | DIHYDROLIPOYLDEHYDROGENASE (Sinorhizobiummeliloti) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 4 | SER A 56GLU A 189TYR A 354SER A 165 | NoneFAD A 500 ( 4.5A)FAD A 500 (-4.5A)FAD A 500 (-3.5A) | 1.11A | 1vidA-3urhA:undetectable | 1vidA-3urhA:18.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3us8 | ISOCITRATEDEHYDROGENASE [NADP] (Sinorhizobiummeliloti) |
PF00180(Iso_dh) | 4 | GLU A 12TYR A 41SER A 330ASP A 28 | None | 1.06A | 1vidA-3us8A:undetectable | 1vidA-3us8A:20.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3va6 | TWO-COMPONENT SYSTEMSENSOR HISTIDINEKINASE (Bacteroidesthetaiotaomicron) |
PF07494(Reg_prop)PF07495(Y_Y_Y) | 4 | SER A 49TYR A 93SER A 263ASP A 324 | None | 1.38A | 1vidA-3va6A:undetectable | 1vidA-3va6A:14.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wcy | INTERFERONALPHA/BETA RECEPTOR1 (Mus musculus) |
PF01108(Tissue_fac)PF09294(Interfer-bind) | 4 | SER A 245GLU A 106SER A 103ASP A 126 | None | 1.30A | 1vidA-3wcyA:undetectable | 1vidA-3wcyA:17.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a2l | TWO-COMPONENT SYSTEMSENSOR HISTIDINEKINASE/RESPONSE (Bacteroidesthetaiotaomicron) |
PF07494(Reg_prop)PF07495(Y_Y_Y) | 4 | SER A 47GLU A 137TYR A 180ASP A 49 | None | 1.17A | 1vidA-4a2lA:undetectable | 1vidA-4a2lA:15.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4doe | 1,4-BETA-GLUCANASE (Caldicellulosiruptorbescii) |
PF00759(Glyco_hydro_9) | 4 | SER A 229GLU A 177TYR A 90SER A 238 | EDO A 522 (-3.3A)NoneNoneNone | 1.26A | 1vidA-4doeA:undetectable | 1vidA-4doeA:18.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dqv | PROBABLE PEPTIDESYNTHETASE NRP(PEPTIDE SYNTHASE) (Mycobacteriumtuberculosis) |
PF07993(NAD_binding_4) | 4 | GLU A 236TYR A 190SER A 215ASP A 195 | None | 1.27A | 1vidA-4dqvA:6.8 | 1vidA-4dqvA:19.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f4c | MULTIDRUG RESISTANCEPROTEIN PGP-1 (Caenorhabditiselegans) |
PF00005(ABC_tran)PF00664(ABC_membrane) | 4 | GLU A 297TYR A 296SER A 283ASP A1166 | None | 1.49A | 1vidA-4f4cA:undetectable | 1vidA-4f4cA:10.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f4c | MULTIDRUG RESISTANCEPROTEIN PGP-1 (Caenorhabditiselegans) |
PF00005(ABC_tran)PF00664(ABC_membrane) | 4 | GLU A 297TYR A 296SER A 284ASP A1166 | None | 1.23A | 1vidA-4f4cA:undetectable | 1vidA-4f4cA:10.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hcx | ISOCITRATEDEHYDROGENASE [NADP] (Mycobacteriumtuberculosis) |
PF00180(Iso_dh) | 4 | GLU A 15TYR A 44SER A 335ASP A 31 | None | 1.11A | 1vidA-4hcxA:undetectable | 1vidA-4hcxA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hum | MULTIDRUG EFFLUXPROTEINPROTEIN B (Neisseriagonorrhoeae;Escherichiacoli) |
PF01554(MatE)PF00041(fn3) | 4 | SER B 55GLU B 9SER A 460ASP B 23 | None | 1.18A | 1vidA-4humB:undetectable | 1vidA-4humB:18.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jcm | CYCLODEXTRINGLUCANOTRANSFERASE ([Bacillus]clarkii) |
PF00128(Alpha-amylase)PF00686(CBM_20)PF01833(TIG) | 4 | SER A 205TYR A 165SER A 139ASP A 101 | None | 0.95A | 1vidA-4jcmA:undetectable | 1vidA-4jcmA:16.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oue | PUTATIVE LIPOPROTEIN (Bacteroidesthetaiotaomicron) |
PF00754(F5_F8_type_C)PF01120(Alpha_L_fucos) | 4 | SER A 114TYR A 110SER A 156ASP A 112 | None | 1.37A | 1vidA-4oueA:undetectable | 1vidA-4oueA:19.26 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4p58 | CATECHOLO-METHYLTRANSFERASE (Mus musculus) |
PF01596(Methyltransf_3) | 5 | SER A 115GLU A 133TYR A 138SER A 162ASP A 184 | None2F6 A 301 (-2.7A)None2F6 A 301 (-3.2A)None | 0.70A | 1vidA-4p58A:33.0 | 1vidA-4p58A:97.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r0v | FE-HYDROGENASE (Chlamydomonasreinhardtii) |
PF02256(Fe_hyd_SSU)PF02906(Fe_hyd_lg_C) | 4 | SER A 230GLU A 178TYR A 485SER A 180 | None | 1.32A | 1vidA-4r0vA:undetectable | 1vidA-4r0vA:16.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rl4 | GTP CYCLOHYDROLASE-2 (Helicobacterpylori) |
PF00925(GTP_cyclohydro2) | 4 | SER A 63GLU A 92SER A 53ASP A 67 | NoneNonePPV A 201 ( 4.8A)None | 1.45A | 1vidA-4rl4A:undetectable | 1vidA-4rl4A:21.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zv7 | LIPASE B (Moesziomycesantarcticus) |
no annotation | 4 | SER A 227TYR A 135SER A 195ASP A 187 | None | 1.42A | 1vidA-4zv7A:undetectable | 1vidA-4zv7A:21.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c8s | GUANINE-N7METHYLTRANSFERASE (Severe acuterespiratorysyndrome-relatedcoronavirus) |
PF06471(NSP11) | 4 | SER B 220TYR B 224SER B 171ASP B 234 | None | 1.42A | 1vidA-5c8sB:undetectable | 1vidA-5c8sB:18.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dl6 | PUTATIVE PORIN FORVANILLATETRAFFICKING (VANP) (Acinetobacterbaumannii) |
PF03573(OprD) | 4 | GLU A 345TYR A 371SER A 305ASP A 290 | None | 1.44A | 1vidA-5dl6A:undetectable | 1vidA-5dl6A:22.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ftz | CHITIN BINDINGPROTEIN (Streptomyceslividans) |
PF03067(LPMO_10) | 4 | SER A 143TYR A 128SER A 79ASP A 74 | None | 1.40A | 1vidA-5ftzA:undetectable | 1vidA-5ftzA:22.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5huu | ALPHA,ALPHA-TREHALOSE-PHOSPHATE SYNTHASE[UDP-FORMING] (Candidaalbicans) |
PF00982(Glyco_transf_20) | 4 | SER A 375TYR A 283SER A 332ASP A 279 | None | 1.30A | 1vidA-5huuA:3.1 | 1vidA-5huuA:19.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hzh | RAS-RELATED C3BOTULINUM TOXINSUBSTRATE1,NPH1-1,RAS-RELATEDC3 BOTULINUM TOXINSUBSTRATE 1 (Avena sativa;Homo sapiens) |
PF00071(Ras)PF13426(PAS_9) | 4 | GLU A 305TYR A 288SER A 307ASP A 270 | NoneNoneGTP A 401 (-3.5A)None | 1.38A | 1vidA-5hzhA:undetectable | 1vidA-5hzhA:21.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tr3 | DIHYDROLIPOYLDEHYDROGENASE (Pseudomonasputida) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 4 | SER A 64GLU A 195TYR A 358SER A 171 | NoneFAD A 501 ( 4.6A)FAD A 501 (-4.1A)FAD A 501 (-3.5A) | 1.07A | 1vidA-5tr3A:undetectable | 1vidA-5tr3A:17.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5us1 | AMINOGLYCOSIDE2'-N-ACETYLTRANSFERASE (Providenciastuartii) |
PF13673(Acetyltransf_10) | 4 | SER A 116GLU A 79TYR A 77SER A 34 | 8MM A 201 (-3.7A)8MM A 201 (-4.5A)NoneNone | 1.47A | 1vidA-5us1A:undetectable | 1vidA-5us1A:20.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wdr | RAS PROTEIN (Choanoflagellida) |
PF00071(Ras) | 4 | SER A 89GLU A 144SER A 146ASP A 85 | NoneNoneGNP A 203 (-3.5A)None | 1.36A | 1vidA-5wdrA:3.0 | 1vidA-5wdrA:22.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y4g | AMBP3 (Fischerellaambigua) |
no annotation | 4 | GLU A 207TYR A 168SER A 287ASP A 277 | None | 1.08A | 1vidA-5y4gA:undetectable | 1vidA-5y4gA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yyl | - (-) |
no annotation | 4 | SER A 186GLU A 211TYR A 233SER A 228 | None | 1.43A | 1vidA-5yylA:undetectable | 1vidA-5yylA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bz0 | DIHYDROLIPOYLDEHYDROGENASE (Acinetobacterbaumannii) |
no annotation | 4 | SER A 63GLU A 194TYR A 357SER A 170 | NoneFAD A 501 ( 4.5A)FAD A 501 (-4.3A) CL A 502 ( 2.9A) | 1.13A | 1vidA-6bz0A:undetectable | 1vidA-6bz0A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6eua | ANGIOPOIETIN-RELATEDPROTEIN 3 (Homo sapiens) |
no annotation | 4 | SER A 280GLU A 346TYR A 344SER A 348 | None | 1.41A | 1vidA-6euaA:undetectable | 1vidA-6euaA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6evj | RNA-DIRECTED RNAPOLYMERASE CATALYTICSUBUNIT (Influenza Avirus) |
no annotation | 4 | SER B 443GLU B 491SER B 482ASP B 445 | None | 1.39A | 1vidA-6evjB:undetectable | 1vidA-6evjB:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gct | NEUTRAL AMINO ACIDTRANSPORTER B(0) (Homo sapiens) |
no annotation | 4 | SER A 454GLU A 291SER A 87ASP A 451 | None | 1.31A | 1vidA-6gctA:undetectable | 1vidA-6gctA:undetectable |