SIMILAR PATTERNS OF AMINO ACIDS FOR 1VE3_B_SAMB301_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cb8 PROTEIN
(CHONDROITINASE AC)


(Pedobacter
heparinus)
PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N)
5 GLY A 394
ILE A 276
SER A 279
ILE A 390
SER A 357
None
1.16A 1ve3B-1cb8A:
undetectable
1ve3B-1cb8A:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1deu PROCATHEPSIN X

(Homo sapiens)
PF00112
(Peptidase_C1)
5 ALA A 185
GLY A 186
ALA A  16
ILE A 151
SER A 183
None
1.14A 1ve3B-1deuA:
undetectable
1ve3B-1deuA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ef7 CATHEPSIN X

(Homo sapiens)
PF00112
(Peptidase_C1)
5 ALA A 185
GLY A 186
ALA A  16
ILE A 151
SER A 183
None
1.15A 1ve3B-1ef7A:
undetectable
1ve3B-1ef7A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eth TRIACYLGLYCEROL
ACYL-HYDROLASE


(Sus scrofa)
PF00151
(Lipase)
PF01477
(PLAT)
5 TYR A 271
GLY A 175
ALA A 197
ILE A  75
HIS A 148
None
1.09A 1ve3B-1ethA:
undetectable
1ve3B-1ethA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8w NADH PEROXIDASE

(Enterococcus
faecalis)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 ALA A 165
GLY A 161
ALA A 169
ILE A 208
PHE A 332
None
1.14A 1ve3B-1f8wA:
4.0
1ve3B-1f8wA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hpl LIPASE

(Equus caballus)
PF00151
(Lipase)
PF01477
(PLAT)
5 TYR A 270
GLY A 174
ALA A 196
ILE A  74
HIS A 147
None
1.16A 1ve3B-1hplA:
undetectable
1ve3B-1hplA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jc9 TECHYLECTIN-5A

(Tachypleus
tridentatus)
PF00147
(Fibrinogen_C)
5 GLY A 212
SER A 193
ILE A 240
HIS A 187
PHE A 184
None
1.15A 1ve3B-1jc9A:
undetectable
1ve3B-1jc9A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jji CARBOXYLESTERASE

(Archaeoglobus
fulgidus)
PF07859
(Abhydrolase_3)
5 TYR A  85
GLY A 163
ILE A 185
ALA A 247
SER A 170
None
1.10A 1ve3B-1jjiA:
2.5
1ve3B-1jjiA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jkm BREFELDIN A ESTERASE

(Bacillus
subtilis)
PF07859
(Abhydrolase_3)
5 TYR A 233
GLY A 126
ILE A 131
HIS A 338
PHE A 259
None
1.15A 1ve3B-1jkmA:
2.6
1ve3B-1jkmA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens)
PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3)
5 GLY A 536
ILE A 357
ALA A 359
ILE A 530
SER A 522
None
1.09A 1ve3B-1kcwA:
undetectable
1ve3B-1kcwA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kph CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE 1


(Mycobacterium
tuberculosis)
PF02353
(CMAS)
5 TYR A  16
GLY A  74
ILE A 136
HIS A 141
PHE A 142
SAH  A1900 ( 4.2A)
SAH  A1900 (-3.2A)
SAH  A1900 (-4.2A)
SAH  A1900 (-4.4A)
SAH  A1900 ( 4.6A)
1.06A 1ve3B-1kphA:
16.9
1ve3B-1kphA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lvl DIHYDROLIPOAMIDE
DEHYDROGENASE


(Pseudomonas
putida)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 ALA A 324
GLY A 320
ILE A 326
ALA A 328
ILE A  22
None
1.02A 1ve3B-1lvlA:
4.1
1ve3B-1lvlA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qv0 OBELIN

(Obelia
longissima)
PF00036
(EF-hand_1)
PF13202
(EF-hand_5)
5 TYR A 190
ALA A 186
GLY A 188
ARG A 173
HIS A 175
CZH  A 201 (-4.3A)
None
None
None
CZH  A 201 (-3.5A)
1.05A 1ve3B-1qv0A:
undetectable
1ve3B-1qv0A:
24.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ve3 HYPOTHETICAL PROTEIN
PH0226


(Pyrococcus
horikoshii)
PF13649
(Methyltransf_25)
6 ALA A  46
ILE A  68
SER A  69
ALA A  94
ARG A  95
ILE A 108
SAM  A 302 (-3.4A)
SAM  A 302 (-3.7A)
SAM  A 302 (-4.7A)
SAM  A 302 (-3.3A)
None
None
1.27A 1ve3B-1ve3A:
35.3
1ve3B-1ve3A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ve3 HYPOTHETICAL PROTEIN
PH0226


(Pyrococcus
horikoshii)
PF13649
(Methyltransf_25)
12 TYR A   7
TYR A  13
ALA A  46
GLY A  48
ILE A  68
SER A  69
ALA A  94
ARG A  95
ILE A 110
SER A 112
HIS A 115
PHE A 116
SAM  A 302 (-4.6A)
SAM  A 302 (-3.4A)
SAM  A 302 (-3.4A)
SAM  A 302 (-3.6A)
SAM  A 302 (-3.7A)
SAM  A 302 (-4.7A)
SAM  A 302 (-3.3A)
None
SAM  A 302 (-3.8A)
SAM  A 302 (-3.3A)
SAM  A 302 (-3.8A)
SAM  A 302 (-4.4A)
0.49A 1ve3B-1ve3A:
35.3
1ve3B-1ve3A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vl5 UNKNOWN CONSERVED
PROTEIN BH2331


(Bacillus
halodurans)
PF08241
(Methyltransf_11)
5 ALA A  50
GLY A  52
ALA A  99
HIS A 120
PHE A 121
None
1.00A 1ve3B-1vl5A:
21.3
1ve3B-1vl5A:
26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w1w STRUCTURAL
MAINTENANCE OF
CHROMOSOME 1


(Saccharomyces
cerevisiae)
PF02463
(SMC_N)
5 ALA A1172
ARG A1176
ILE A1188
SER A  30
PHE A  28
None
1.12A 1ve3B-1w1wA:
undetectable
1ve3B-1w1wA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8j MYOSIN VA

(Gallus gallus)
PF00063
(Myosin_head)
5 TYR A 658
ILE A 438
SER A 162
ILE A 433
SER A 158
None
1.06A 1ve3B-1w8jA:
undetectable
1ve3B-1w8jA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y14 DNA-DIRECTED RNA
POLYMERASE II 32 KDA
POLYPEPTIDE


(Saccharomyces
cerevisiae)
PF03874
(RNA_pol_Rpb4)
5 ALA A 178
GLY A 181
SER A  53
ALA A  49
ILE A 195
None
1.10A 1ve3B-1y14A:
undetectable
1ve3B-1y14A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ado MEDIATOR OF DNA
DAMAGE CHECKPOINT
PROTEIN 1


(Homo sapiens)
PF16770
(RTT107_BRCT_5)
5 TYR A2025
GLY A2023
ALA A2074
ILE A2017
PHE A2064
None
0.96A 1ve3B-2adoA:
undetectable
1ve3B-2adoA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dis UNNAMED PROTEIN
PRODUCT


(Homo sapiens)
PF00076
(RRM_1)
5 TYR A  59
ALA A  55
ILE A  40
ARG A  22
ILE A  84
None
1.08A 1ve3B-2disA:
undetectable
1ve3B-2disA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9z CHEMOTAXIS PROTEIN
CHEC


(Thermotoga
maritima)
PF04509
(CheC)
5 GLY A  80
SER A 183
ALA A  53
ILE A  59
PHE A 149
None
0.95A 1ve3B-2f9zA:
undetectable
1ve3B-2f9zA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fzw ALCOHOL
DEHYDROGENASE CLASS
III CHI CHAIN


(Homo sapiens)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 ALA A 280
GLY A 260
ALA A 276
SER A 264
PHE A 197
None
1.16A 1ve3B-2fzwA:
5.8
1ve3B-2fzwA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gj3 NITROGEN FIXATION
REGULATORY PROTEIN


(Azotobacter
vinelandii)
PF00989
(PAS)
5 TYR A 110
GLY A  59
ALA A  50
ILE A  72
HIS A 133
None
None
None
None
FAD  A 500 ( 4.8A)
1.09A 1ve3B-2gj3A:
undetectable
1ve3B-2gj3A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h1n OLIGOENDOPEPTIDASE F

(Geobacillus
stearothermophilus)
PF01432
(Peptidase_M3)
5 ALA A 324
GLY A 322
ILE A  63
ILE A 145
HIS A  61
None
1.01A 1ve3B-2h1nA:
undetectable
1ve3B-2h1nA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j6l ALDEHYDE
DEHYDROGENASE FAMILY
7 MEMBER A1


(Homo sapiens)
PF00171
(Aldedh)
5 ALA A 394
ALA A 397
ARG A 308
HIS A 392
PHE A 409
None
1.07A 1ve3B-2j6lA:
4.5
1ve3B-2j6lA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pby GLUTAMINASE

(Geobacillus
kaustophilus)
PF04960
(Glutaminase)
5 GLY A 242
ILE A 115
ALA A 119
ILE A  66
SER A  65
None
1.09A 1ve3B-2pbyA:
undetectable
1ve3B-2pbyA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE


(Thermus
thermophilus)
PF13561
(adh_short_C2)
5 ALA A  18
GLY A  14
SER A  10
ALA A  46
ARG A  47
None
1.02A 1ve3B-2ph3A:
2.1
1ve3B-2ph3A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pp3 L-TALARATE/GALACTARA
TE DEHYDRATASE


(Salmonella
enterica)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 GLY A  77
ILE A 135
ALA A  93
ILE A  62
SER A  79
None
1.07A 1ve3B-2pp3A:
undetectable
1ve3B-2pp3A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qae DIHYDROLIPOYL
DEHYDROGENASE


(Trypanosoma
cruzi)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 ALA A 334
GLY A 330
ILE A 336
ALA A 338
ILE A  19
None
1.13A 1ve3B-2qaeA:
4.4
1ve3B-2qaeA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yuj UBIQUITIN FUSION
DEGRADATION 1-LIKE


(Homo sapiens)
PF03152
(UFD1)
5 TYR A  60
GLY A  78
ILE A 179
SER A 178
ARG A 144
None
1.03A 1ve3B-2yujA:
undetectable
1ve3B-2yujA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zzr UNSATURATED
GLUCURONYL HYDROLASE


(Streptococcus
agalactiae)
PF07470
(Glyco_hydro_88)
5 TYR A 347
ALA A 307
ALA A 250
SER A 289
PHE A 279
None
1.07A 1ve3B-2zzrA:
undetectable
1ve3B-2zzrA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3axx 458AA LONG
HYPOTHETICAL
ENDO-1,4-BETA-GLUCAN
ASE


(Pyrococcus
horikoshii)
PF00150
(Cellulase)
5 TYR A 299
GLY A 345
ILE A 389
SER A 378
PHE A  69
None
1.13A 1ve3B-3axxA:
undetectable
1ve3B-3axxA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bus METHYLTRANSFERASE

(Lechevalieria
aerocolonigenes)
PF08241
(Methyltransf_11)
6 GLY A  71
ILE A  92
SER A  93
ALA A 120
SER A 138
HIS A 141
SAH  A 274 (-3.4A)
SAH  A 274 (-4.0A)
None
SAH  A 274 (-3.5A)
None
SAH  A 274 (-4.0A)
0.81A 1ve3B-3busA:
19.1
1ve3B-3busA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxo N,N-DIMETHYLTRANSFER
ASE


(Streptomyces
venezuelae)
PF13649
(Methyltransf_25)
5 ALA A  46
GLY A  48
SER A  69
ARG A  91
SER A 108
SAM  A 238 (-3.2A)
SAM  A 238 ( 3.7A)
SAM  A 238 (-4.6A)
SAM  A 238 (-4.1A)
SAM  A 238 (-3.2A)
0.85A 1ve3B-3bxoA:
18.7
1ve3B-3bxoA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cny INOSITOL CATABOLISM
PROTEIN IOLE


(Lactobacillus
plantarum)
PF01261
(AP_endonuc_2)
5 ALA A 106
GLY A  72
ALA A 149
HIS A  94
PHE A  91
None
None
None
EDO  A 302 ( 3.7A)
None
1.03A 1ve3B-3cnyA:
undetectable
1ve3B-3cnyA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ege PUTATIVE
METHYLTRANSFERASE
FROM ANTIBIOTIC
BIOSYNTHESIS PATHWAY


(Trichormus
variabilis)
PF08241
(Methyltransf_11)
5 GLY A  43
SER A  64
ALA A  84
ILE A 100
HIS A 105
EDO  A 261 ( 3.9A)
None
None
None
EDO  A 261 ( 4.6A)
0.85A 1ve3B-3egeA:
16.1
1ve3B-3egeA:
27.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B


(Sulfolobus
solfataricus)
PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
5 TYR B 314
ILE B 190
ALA B 168
ILE B 521
HIS B 300
None
1.16A 1ve3B-3hkzB:
undetectable
1ve3B-3hkzB:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3im8 MALONYL ACYL CARRIER
PROTEIN TRANSACYLASE


(Streptococcus
pneumoniae)
PF00698
(Acyl_transf_1)
5 ALA A   9
GLY A  88
ALA A  13
ILE A 272
SER A  69
None
1.11A 1ve3B-3im8A:
undetectable
1ve3B-3im8A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kd9 COENZYME A DISULFIDE
REDUCTASE


(Pyrococcus
horikoshii)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 ALA A 168
GLY A 171
ALA A 164
HIS A 203
PHE A 330
None
1.13A 1ve3B-3kd9A:
4.4
1ve3B-3kd9A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kkl PROBABLE CHAPERONE
PROTEIN HSP33


(Saccharomyces
cerevisiae)
no annotation 5 ALA A 231
ILE A 229
SER A 226
ILE A 134
PHE A  38
None
1.16A 1ve3B-3kklA:
3.6
1ve3B-3kklA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kpx APOPHOTOPROTEIN
CLYTIN-3


(Clytia gregaria)
PF13202
(EF-hand_5)
5 TYR A 193
ALA A 189
GLY A 191
ARG A 176
HIS A 178
None
None
None
None
CZH  A 201 (-3.3A)
1.07A 1ve3B-3kpxA:
undetectable
1ve3B-3kpxA:
22.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3l8d METHYLTRANSFERASE

(Bacillus
thuringiensis)
PF08241
(Methyltransf_11)
5 GLY A  63
ILE A  83
SER A  84
ILE A 123
SER A 125
None
1.00A 1ve3B-3l8dA:
18.6
1ve3B-3l8dA:
30.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lib HYPOTHETICAL SENSORY
TRANSDUCTION
HISTIDINE KINASE


(Methanosarcina
mazei)
PF02743
(dCache_1)
5 TYR A 155
GLY A 196
SER A  72
ALA A  86
PHE A 131
None
1.00A 1ve3B-3libA:
undetectable
1ve3B-3libA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1l 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE


(Mycobacterium
tuberculosis)
PF13561
(adh_short_C2)
5 ALA A 387
ILE A 444
ALA A 389
ARG A 445
ILE A 370
None
0.92A 1ve3B-3m1lA:
7.3
1ve3B-3m1lA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oks 4-AMINOBUTYRATE
TRANSAMINASE


(Mycolicibacterium
smegmatis)
PF00202
(Aminotran_3)
6 TYR A 322
ALA A 328
GLY A 324
ILE A 294
SER A 301
ALA A 331
None
1.34A 1ve3B-3oksA:
undetectable
1ve3B-3oksA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oms PHNB PROTEIN

(Bacillus cereus)
PF06983
(3-dmu-9_3-mt)
5 ALA A  18
GLY A  16
ILE A  66
SER A  68
ALA A  54
None
0.99A 1ve3B-3omsA:
undetectable
1ve3B-3omsA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3px2 N-METHYLTRANSFERASE

(Streptomyces
fradiae)
PF13649
(Methyltransf_25)
5 ALA A  58
GLY A  60
SER A  81
ARG A 103
SER A 120
SAH  A 263 (-3.5A)
SAH  A 263 (-3.3A)
SAH  A 263 (-4.7A)
SAH  A 263 ( 4.7A)
SAH  A 263 (-3.3A)
0.82A 1ve3B-3px2A:
19.7
1ve3B-3px2A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q8n 4-AMINOBUTYRATE
TRANSAMINASE


(Mycolicibacterium
smegmatis)
PF00202
(Aminotran_3)
6 TYR A 323
ALA A 329
GLY A 325
ILE A 295
SER A 302
ALA A 332
None
1.34A 1ve3B-3q8nA:
2.0
1ve3B-3q8nA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qhb SYMERYTHRIN

(Cyanophora
paradoxa)
PF02915
(Rubrerythrin)
5 ALA A 120
GLY A 116
ALA A 124
ILE A 103
PHE A  64
None
1.13A 1ve3B-3qhbA:
undetectable
1ve3B-3qhbA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qpc CUTINASE

(Fusarium solani)
PF01083
(Cutinase)
5 ALA A 126
GLY A 122
ALA A 116
SER A 129
PHE A 102
None
MIR  A 120 ( 4.0A)
None
None
None
1.14A 1ve3B-3qpcA:
2.1
1ve3B-3qpcA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5p RIBOSE 5-PHOSPHATE
ISOMERASE


(Giardia
intestinalis)
PF02502
(LacAB_rpiB)
5 ALA A 105
GLY A 107
ILE A  62
ALA A 103
ILE A  69
None
1.10A 1ve3B-3s5pA:
undetectable
1ve3B-3s5pA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s8m ENOYL-ACP REDUCTASE

(Xanthomonas
oryzae)
PF07055
(Eno-Rase_FAD_bd)
PF12241
(Enoyl_reductase)
PF12242
(Eno-Rase_NADH_b)
5 ALA A  62
GLY A  64
ILE A  28
ALA A  98
PHE A  94
None
1.14A 1ve3B-3s8mA:
6.2
1ve3B-3s8mA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sdo NITRILOTRIACETATE
MONOOXYGENASE


(Burkholderia
pseudomallei)
PF00296
(Bac_luciferase)
5 ALA A 225
ILE A 222
SER A 217
ALA A 252
ILE A 212
None
1.15A 1ve3B-3sdoA:
undetectable
1ve3B-3sdoA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3toj SET1/ASH2 HISTONE
METHYLTRANSFERASE
COMPLEX SUBUNIT ASH2


(Homo sapiens)
PF00622
(SPRY)
5 TYR A 364
GLY A 345
SER A 473
ALA A 318
ILE A 396
None
1.05A 1ve3B-3tojA:
undetectable
1ve3B-3tojA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uf0 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR


(Beutenbergia
cavernae)
PF13561
(adh_short_C2)
5 ALA A 185
GLY A 187
ILE A 141
ALA A 183
SER A 146
None
None
NAP  A 274 (-4.3A)
None
None
1.01A 1ve3B-3uf0A:
6.7
1ve3B-3uf0A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3urh DIHYDROLIPOYL
DEHYDROGENASE


(Sinorhizobium
meliloti)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 ALA A 334
GLY A 330
ILE A 336
ALA A 338
ILE A  19
None
1.13A 1ve3B-3urhA:
undetectable
1ve3B-3urhA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zu4 PUTATIVE REDUCTASE
YPO4104/Y4119/YP_401
1


(Yersinia pestis)
PF07055
(Eno-Rase_FAD_bd)
PF12241
(Enoyl_reductase)
PF12242
(Eno-Rase_NADH_b)
5 ALA A  62
GLY A  64
ILE A  28
ALA A  98
PHE A  94
None
1.14A 1ve3B-3zu4A:
6.1
1ve3B-3zu4A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4atq 4-AMINOBUTYRATE
TRANSAMINASE


(Paenarthrobacter
aurescens)
PF00202
(Aminotran_3)
6 TYR A 325
ALA A 331
GLY A 327
ILE A 297
SER A 304
ALA A 334
None
1.35A 1ve3B-4atqA:
undetectable
1ve3B-4atqA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4avy PROBABLE SHORT-CHAIN
DEHYDROGENASE


(Pseudomonas
aeruginosa)
PF13561
(adh_short_C2)
5 ALA A 175
GLY A 177
ILE A 131
ALA A 173
SER A 136
None
1.07A 1ve3B-4avyA:
6.7
1ve3B-4avyA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxs VENOM PROTHROMBIN
ACTIVATOR
PSEUTARIN-C
NON-CATALYTIC
SUBUNIT


(Pseudonaja
textilis)
PF00754
(F5_F8_type_C)
PF07732
(Cu-oxidase_3)
5 GLY V 957
ILE V 800
ALA V 802
ILE V 951
SER V 943
None
1.07A 1ve3B-4bxsV:
undetectable
1ve3B-4bxsV:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d72 GLYCOSIDE HYDROLASE

(Streptococcus
pneumoniae)
PF08306
(Glyco_hydro_98M)
PF08307
(Glyco_hydro_98C)
5 ALA A 792
ILE A 816
ARG A 827
SER A 638
PHE A 769
None
1.11A 1ve3B-4d72A:
undetectable
1ve3B-4d72A:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euf PUTATIVE REDUCTASE
CA_C0462


(Clostridium
acetobutylicum)
PF07055
(Eno-Rase_FAD_bd)
PF12241
(Enoyl_reductase)
PF12242
(Eno-Rase_NADH_b)
5 ALA A  61
GLY A  63
ILE A  28
ALA A  98
PHE A  94
None
1.08A 1ve3B-4eufA:
5.9
1ve3B-4eufA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g6c BETA-HEXOSAMINIDASE
1


(Burkholderia
cenocepacia)
PF00933
(Glyco_hydro_3)
5 ALA A 273
GLY A 277
SER A 232
ALA A 269
SER A 252
None
0.96A 1ve3B-4g6cA:
undetectable
1ve3B-4g6cA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hp8 2-DEOXY-D-GLUCONATE
3-DEHYDROGENASE


(Agrobacterium
fabrum)
PF13561
(adh_short_C2)
5 ALA A 181
GLY A 183
ILE A 137
ALA A 179
SER A 142
None
None
NAP  A 301 (-4.5A)
None
None
1.03A 1ve3B-4hp8A:
6.9
1ve3B-4hp8A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iuy SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE


(Acinetobacter
baumannii)
PF00106
(adh_short)
5 ALA A 188
GLY A 190
ILE A 144
ALA A 186
SER A 149
None
0.88A 1ve3B-4iuyA:
6.7
1ve3B-4iuyA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kh9 HYPOTHETICAL PROTEIN

(Legionella
pneumophila)
PF16024
(DUF4785)
5 GLY A  66
ILE A 171
SER A 172
ILE A 271
SER A  83
None
1.13A 1ve3B-4kh9A:
undetectable
1ve3B-4kh9A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kqc PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR


(Brachyspira
murdochii)
PF13407
(Peripla_BP_4)
5 GLY A 112
ILE A 297
ALA A  47
ILE A  87
PHE A  60
None
1.16A 1ve3B-4kqcA:
undetectable
1ve3B-4kqcA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p9j RYANODINE RECEPTOR 1

(Oryctolagus
cuniculus)
no annotation 5 TYR C1122
GLY C1103
SER C1193
ALA C1077
ILE C1153
None
1.15A 1ve3B-4p9jC:
undetectable
1ve3B-4p9jC:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdr NEUROPILIN-2

(Homo sapiens)
PF00754
(F5_F8_type_C)
5 ALA A 519
GLY A 505
ALA A 517
ILE A 583
SER A 579
None
1.11A 1ve3B-4qdrA:
undetectable
1ve3B-4qdrA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8x URICASE

(Bacillus
fastidiosus)
PF01014
(Uricase)
5 GLY A 268
ILE A 166
ALA A 232
ARG A 229
ILE A 244
None
1.09A 1ve3B-4r8xA:
undetectable
1ve3B-4r8xA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rjk ACETOLACTATE
SYNTHASE


(Bacillus
subtilis)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
5 ALA A 196
GLY A 194
ALA A 200
ILE A 329
HIS A 335
None
1.14A 1ve3B-4rjkA:
2.2
1ve3B-4rjkA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1g RETICULOCYTE BINDING
PROTEIN 5


(Plasmodium
falciparum)
no annotation 5 GLY A 336
ILE A 193
SER A 192
ALA A 205
ILE A 213
None
1.16A 1ve3B-4u1gA:
undetectable
1ve3B-4u1gA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u4e THIOLASE

(Sphaerobacter
thermophilus)
PF02803
(Thiolase_C)
5 ALA A  55
GLY A  75
ILE A  57
SER A  58
ILE A  85
None
1.12A 1ve3B-4u4eA:
undetectable
1ve3B-4u4eA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjl INACTIVE DIPEPTIDYL
PEPTIDASE 10


(Homo sapiens)
PF00326
(Peptidase_S9)
PF00930
(DPPIV_N)
5 GLY A 654
ILE A 566
ILE A 721
SER A 672
PHE A 777
None
1.09A 1ve3B-4wjlA:
undetectable
1ve3B-4wjlA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x8n SET1/ASH2 HISTONE
METHYLTRANSFERASE
COMPLEX SUBUNIT ASH2


(Homo sapiens)
PF00622
(SPRY)
5 TYR A 364
GLY A 345
SER A 473
ALA A 318
ILE A 396
None
1.06A 1ve3B-4x8nA:
undetectable
1ve3B-4x8nA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4za2 2-DEOXY-D-GLUCONATE
3-DEHYDROGENASE


(Pectobacterium
carotovorum)
PF13561
(adh_short_C2)
5 ALA A 187
GLY A 189
ILE A 143
ALA A 185
SER A 148
None
1.07A 1ve3B-4za2A:
6.2
1ve3B-4za2A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zch TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
13,TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
13B,TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
13B


(Homo sapiens)
PF00229
(TNF)
5 ALA A 256
GLY A 205
SER A 105
ILE A 203
PHE A 353
None
1.14A 1ve3B-4zchA:
undetectable
1ve3B-4zchA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aex AMMONIUM TRANSPORTER
MEP2


(Saccharomyces
cerevisiae)
PF00909
(Ammonium_transp)
5 ALA A 395
GLY A 391
ILE A 397
ALA A 399
SER A 184
None
1.13A 1ve3B-5aexA:
undetectable
1ve3B-5aexA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cm2 TRNA
METHYLTRANSFERASE


(Yarrowia
lipolytica)
PF08241
(Methyltransf_11)
5 GLY Z  66
SER Z  85
ALA Z 106
ILE Z 122
PHE Z 128
None
0.86A 1ve3B-5cm2Z:
17.1
1ve3B-5cm2Z:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ew5 COLICIN-E9

(Escherichia
coli)
PF03515
(Cloacin)
5 GLY A 219
ILE A 233
SER A 234
ALA A 212
SER A 279
None
1.09A 1ve3B-5ew5A:
undetectable
1ve3B-5ew5A:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gm2 O-METHYLRANSFERASE

(Streptomyces
blastmyceticus)
PF08241
(Methyltransf_11)
6 GLY A  87
SER A 109
ALA A 136
ILE A 152
SER A 154
HIS A 157
SAH  A 301 (-3.1A)
None
SAH  A 301 (-3.4A)
SAH  A 301 (-4.1A)
SAH  A 301 (-4.4A)
SAH  A 301 ( 4.3A)
0.65A 1ve3B-5gm2A:
18.4
1ve3B-5gm2A:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jd4 LAE6

(uncultured
bacterium)
PF07859
(Abhydrolase_3)
5 ALA A 156
GLY A 158
ALA A 183
ILE A 115
PHE A 313
None
1.04A 1ve3B-5jd4A:
undetectable
1ve3B-5jd4A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jyd SHORT CHAIN
DEHYDROGENASE


(Burkholderia
cenocepacia)
PF13561
(adh_short_C2)
5 GLY A  77
ILE A  81
ALA A 286
ILE A 115
HIS A  56
None
NAD  A 901 (-3.8A)
None
None
None
0.96A 1ve3B-5jydA:
6.3
1ve3B-5jydA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kj2 HISTONE
ACETYLTRANSFERASE
P300


(Homo sapiens)
PF08214
(HAT_KAT11)
5 TYR A1585
ILE A1517
SER A1516
SER A1497
PHE A1343
None
1.07A 1ve3B-5kj2A:
undetectable
1ve3B-5kj2A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lkz HISTONE
ACETYLTRANSFERASE
P300,HISTONE
ACETYLTRANSFERASE
P300


(Homo sapiens)
PF00439
(Bromodomain)
PF06001
(DUF902)
PF08214
(HAT_KAT11)
5 TYR A1585
ILE A1517
SER A1516
SER A1497
PHE A1343
None
1.14A 1ve3B-5lkzA:
2.6
1ve3B-5lkzA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mi0 RETICULOCYTE
BINDING-LIKE PROTEIN
5,RETICULOCYTE
BINDING PROTEIN 5


(Plasmodium
falciparum)
no annotation 5 GLY A 336
ILE A 193
SER A 192
ALA A 205
ILE A 213
None
1.13A 1ve3B-5mi0A:
undetectable
1ve3B-5mi0A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nop ATTACHMENT
GLYCOPROTEIN


(Mojiang
henipavirus)
PF00423
(HN)
5 GLY A 352
ILE A 355
ALA A 289
ILE A 580
SER A 567
None
1.04A 1ve3B-5nopA:
undetectable
1ve3B-5nopA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5osn CAPSID PROTEIN

(Enterovirus E)
PF00073
(Rhv)
5 ALA B 165
GLY B 163
ILE B 167
ILE B 207
HIS B 170
None
1.00A 1ve3B-5osnB:
undetectable
1ve3B-5osnB:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5y RNA POLYMERASE
I-SPECIFIC
TRANSCRIPTION
INITIATION FACTOR
RRN6


(Saccharomyces
cerevisiae)
PF10214
(Rrn6)
5 ALA O 426
SER O 429
ILE O 423
SER O 437
PHE O 489
None
1.10A 1ve3B-5w5yO:
undetectable
1ve3B-5w5yO:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7k OXAG

(Penicillium
oxalicum)
no annotation 6 ALA A  54
GLY A  56
ILE A  83
SER A  84
ALA A 110
PHE A 132
SAH  A 301 (-3.4A)
SAH  A 301 (-3.4A)
SAH  A 301 (-3.9A)
None
SAH  A 301 (-3.4A)
SAH  A 301 (-4.6A)
0.84A 1ve3B-5w7kA:
20.2
1ve3B-5w7kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7k OXAG

(Penicillium
oxalicum)
no annotation 6 TYR A  20
ALA A  54
ILE A  83
SER A  84
ALA A 110
PHE A 132
SAH  A 301 (-4.6A)
SAH  A 301 (-3.4A)
SAH  A 301 (-3.9A)
None
SAH  A 301 (-3.4A)
SAH  A 301 (-4.6A)
1.11A 1ve3B-5w7kA:
20.2
1ve3B-5w7kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7m GLANDICOLINE B
O-METHYLTRANSFERASE
ROQN


(Penicillium
rubens)
no annotation 5 ALA A  54
GLY A  56
ILE A  83
SER A  84
ALA A 110
SAH  A 301 (-3.3A)
SAH  A 301 (-3.3A)
SAH  A 301 (-3.5A)
None
SAH  A 301 (-3.5A)
0.47A 1ve3B-5w7mA:
20.0
1ve3B-5w7mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7m GLANDICOLINE B
O-METHYLTRANSFERASE
ROQN


(Penicillium
rubens)
no annotation 5 ALA A  54
GLY A  56
ILE A  83
SER A  84
PHE A 132
SAH  A 301 (-3.3A)
SAH  A 301 (-3.3A)
SAH  A 301 (-3.5A)
None
SAH  A 301 (-4.5A)
0.88A 1ve3B-5w7mA:
20.0
1ve3B-5w7mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wug BETA-GLUCOSIDASE

(Paenibacillus
barengoltzii)
no annotation 5 ALA A 151
ILE A 147
ILE A  65
SER A  67
PHE A  69
None
1.13A 1ve3B-5wugA:
undetectable
1ve3B-5wugA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxi CYTOCHROME P450 2C9

(Homo sapiens)
no annotation 5 ALA A  82
GLY A  79
ILE A 389
SER A 390
ALA A  86
None
1.12A 1ve3B-5xxiA:
undetectable
1ve3B-5xxiA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E


(Pseudomonas sp.
AIU 813)
no annotation 5 ALA A 472
GLY A 471
ALA A 515
ILE A 461
SER A 363
FAD  A 601 (-3.4A)
None
ORN  A 602 ( 3.5A)
None
FAD  A 601 (-3.6A)
1.15A 1ve3B-5yb7A:
undetectable
1ve3B-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE


(Moorella
thermoacetica)
no annotation 5 TYR A1038
ALA A 986
GLY A1065
ALA A 877
SER A 984
None
1.15A 1ve3B-6cipA:
3.8
1ve3B-6cipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ei3 PROTON-DEPENDENT
OLIGOPEPTIDE
TRANSPORTER FAMILY
PROTEIN


(Xanthomonas
campestris)
no annotation 5 ALA A 129
GLY A 131
ARG A  37
ILE A 100
PHE A  69
None
1.06A 1ve3B-6ei3A:
undetectable
1ve3B-6ei3A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fvs CYS-LOOP
LIGAND-GATED ION
CHANNEL


(endosymbiont of
Tevnia
jerichonana)
no annotation 5 ALA A 229
GLY A 231
ILE A 226
ILE A 209
PHE A 217
None
BNG  A 401 ( 2.9A)
None
BNG  A 401 ( 4.8A)
None
1.13A 1ve3B-6fvsA:
undetectable
1ve3B-6fvsA:
undetectable