SIMILAR PATTERNS OF AMINO ACIDS FOR 1V8B_C_ADNC2502_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cs6 AXONIN-1

(Gallus gallus) 		PF07679
(I-set)
PF13927
(Ig_3) 		3 GLU A 311
THR A 310
LEU A 359
 None
 0.71A 1v8bC-1cs6A:
undetectable		 1v8bC-1cs6A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ecg GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Escherichia
coli) 		PF00156
(Pribosyltran)
PF13522
(GATase_6) 		3 GLU A 203
THR A 202
LEU A 221
 None
 0.72A 1v8bC-1ecgA:
2.4		 1v8bC-1ecgA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1guq GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE

(Escherichia
coli) 		PF01087
(GalP_UDP_transf)
PF02744
(GalP_UDP_tr_C) 		3 GLU A 215
THR A 216
LEU A 235
 None
 0.61A 1v8bC-1guqA:
undetectable		 1v8bC-1guqA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hml ALPHA-LACTALBUMIN

(Homo sapiens) 		PF00062
(Lys) 		3 GLU A  49
THR A  48
LEU A  81
 ZN  A 125 ( 2.1A)
None
None
 0.70A 1v8bC-1hmlA:
undetectable		 1v8bC-1hmlA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
ALPHA SUBUNIT

(Saccharomyces
cerevisiae) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		3 GLU A 120
THR A 121
LEU A  84
 None
 0.71A 1v8bC-1hr7A:
undetectable		 1v8bC-1hr7A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhy METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylosinus
trichosporium) 		PF02332
(Phenol_Hydrox) 		3 GLU B  92
THR B  91
LEU B 306
 None
 0.60A 1v8bC-1mhyB:
undetectable		 1v8bC-1mhyB:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgx PROTEIN G

(Streptococcus) 		PF01378
(IgG_binding_B) 		3 GLU A  28
THR A  29
LEU A  25
 None
 0.66A 1v8bC-1pgxA:
undetectable		 1v8bC-1pgxA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8i DNA POLYMERASE II

(Escherichia
coli) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		3 GLU A 579
THR A 580
LEU A 533
 None
 0.66A 1v8bC-1q8iA:
undetectable		 1v8bC-1q8iA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q90 APOCYTOCHROME F

(Chlamydomonas
reinhardtii) 		PF01333
(Apocytochr_F_C)
PF16639
(Apocytochr_F_N) 		3 GLU A 241
THR A 242
LEU A  75
 None
 0.67A 1v8bC-1q90A:
undetectable		 1v8bC-1q90A:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qav NEURONAL NITRIC
OXIDE SYNTHASE
(RESIDUES 1-130)

(Rattus
norvegicus) 		PF00595
(PDZ) 		3 GLU B1108
THR B1109
LEU B1057
 None
 0.64A 1v8bC-1qavB:
undetectable		 1v8bC-1qavB:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rc7 RIBONUCLEASE III

(Aquifex
aeolicus) 		PF00035
(dsrm)
PF14622
(Ribonucleas_3_3) 		3 GLU A 187
THR A 195
LEU A 156
 None
 0.61A 1v8bC-1rc7A:
undetectable		 1v8bC-1rc7A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sky F1-ATPASE

(Bacillus sp.
PS3) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		3 GLU B 320
THR B 321
LEU B 166
 None
 0.66A 1v8bC-1skyB:
2.5		 1v8bC-1skyB:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tua HYPOTHETICAL PROTEIN
APE0754

(Aeropyrum
pernix) 		PF00013
(KH_1) 		3 GLU A 123
THR A 128
LEU A 169
 None
 0.61A 1v8bC-1tuaA:
undetectable		 1v8bC-1tuaA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9k RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE C

(Escherichia
coli) 		PF00849
(PseudoU_synth_2) 		3 GLU A 217
THR A 218
LEU A 195
 None
 0.65A 1v8bC-1v9kA:
undetectable		 1v8bC-1v9kA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdt ELONGATION FACTOR G
HOMOLOG

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		3 GLU A 116
THR A 115
LEU A 149
 None
 0.63A 1v8bC-1wdtA:
2.2		 1v8bC-1wdtA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x5r GLUTAMATE RECEPTOR
INTERACTING PROTEIN
2

(Homo sapiens) 		PF00595
(PDZ) 		3 GLU A  15
THR A  14
LEU A  71
 None
 0.65A 1v8bC-1x5rA:
undetectable		 1v8bC-1x5rA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yni SUCCINYLARGININE
DIHYDROLASE

(Escherichia
coli) 		PF04996
(AstB) 		3 GLU A 324
THR A 302
LEU A 335
 None
 0.65A 1v8bC-1yniA:
undetectable		 1v8bC-1yniA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq2 BETA-GALACTOSIDASE

(Arthrobacter
sp. C2-2) 		PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		3 GLU A 394
THR A 395
LEU A 449
 None
 0.72A 1v8bC-1yq2A:
2.7		 1v8bC-1yq2A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ash QUEUINE
TRNA-RIBOSYLTRANSFER
ASE

(Thermotoga
maritima) 		PF01702
(TGT) 		3 GLU A 226
THR A 225
LEU A 248
 None
 0.63A 1v8bC-2ashA:
undetectable		 1v8bC-2ashA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c5s PROBABLE THIAMINE
BIOSYNTHESIS PROTEIN
THII

(Bacillus
anthracis) 		PF02568
(ThiI)
PF02926
(THUMP) 		3 GLU A 229
THR A 333
LEU A 184
 None
 0.73A 1v8bC-2c5sA:
2.3		 1v8bC-2c5sA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cbz MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1

(Homo sapiens) 		PF00005
(ABC_tran) 		3 GLU A 760
THR A 759
LEU A 768
 None
 0.70A 1v8bC-2cbzA:
undetectable		 1v8bC-2cbzA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eq9 PYRUVATE
DEHYDROGENASE
COMPLEX,
DIHYDROLIPOAMIDE
DEHYDROGENASE E3
COMPONENT

(Thermus
thermophilus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 GLU A 357
THR A 354
LEU A 212
 None
 0.57A 1v8bC-2eq9A:
4.2		 1v8bC-2eq9A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f4o PEPTIDE N-GLYCANASE

(Mus musculus) 		PF01841
(Transglut_core) 		3 GLU A 337
THR A 336
LEU A 227
 None
 0.72A 1v8bC-2f4oA:
undetectable		 1v8bC-2f4oA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o4c ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
PF11890
(DUF3410) 		3 GLU A  48
THR A  47
LEU A  35
 None
 0.69A 1v8bC-2o4cA:
9.5		 1v8bC-2o4cA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9v ATP SYNTHASE SUBUNIT
ALPHA

(Thermotoga
maritima) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		3 GLU A 321
THR A 322
LEU A 167
 None
 0.71A 1v8bC-2r9vA:
undetectable		 1v8bC-2r9vA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6b L-LACTATE
DEHYDROGENASE

(Deinococcus
radiodurans) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 GLU A 259
THR A 258
LEU A  49
 None
 0.71A 1v8bC-2v6bA:
6.2		 1v8bC-2v6bA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6o THIOREDOXIN
GLUTATHIONE
REDUCTASE

(Schistosoma
mansoni) 		PF00462
(Glutaredoxin)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 GLU A 462
THR A 461
LEU A  53
 None
PG4  A1596 ( 4.8A)
None
 0.72A 1v8bC-2v6oA:
4.2		 1v8bC-2v6oA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrn PROTEASE I

(Deinococcus
radiodurans) 		PF01965
(DJ-1_PfpI) 		3 GLU A 123
THR A 124
LEU A  81
 None
 0.69A 1v8bC-2vrnA:
4.2		 1v8bC-2vrnA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wk1 NOVP

(Actinoalloteichus
cyanogriseus) 		PF05711
(TylF) 		3 GLU A  92
THR A  93
LEU A 190
 SAH  A 301 (-2.9A)
None
None
 0.62A 1v8bC-2wk1A:
4.2		 1v8bC-2wk1A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2woc ADP-RIBOSYL-[DINITRO
GEN REDUCTASE]
GLYCOHYDROLASE

(Rhodospirillum
rubrum) 		PF03747
(ADP_ribosyl_GH) 		3 GLU A  63
THR A  62
LEU A 272
 None
 0.65A 1v8bC-2wocA:
undetectable		 1v8bC-2wocA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2woz KELCH REPEAT AND BTB
DOMAIN-CONTAINING
PROTEIN 10

(Rattus
norvegicus) 		PF01344
(Kelch_1) 		3 GLU A 411
THR A 410
LEU A 414
 None
 0.69A 1v8bC-2wozA:
undetectable		 1v8bC-2wozA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yqu 2-OXOGLUTARATE
DEHYDROGENASE E3
COMPONENT

(Thermus
thermophilus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 GLU A 345
THR A 342
LEU A 203
 None
 0.54A 1v8bC-2yquA:
3.5		 1v8bC-2yquA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3j PBP5

(Haemophilus
influenzae) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		3 GLU A 283
THR A 284
LEU A  52
 None
 0.68A 1v8bC-3a3jA:
undetectable		 1v8bC-3a3jA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afg SUBTILISIN-LIKE
SERINE PROTEASE

(Thermococcus
kodakarensis) 		PF00082
(Peptidase_S8)
PF04151
(PPC) 		3 GLU A 390
THR A 391
LEU A 372
 None
 0.72A 1v8bC-3afgA:
3.7		 1v8bC-3afgA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b02 TRANSCRIPTIONAL
REGULATOR, CRP
FAMILY

(Thermus
thermophilus) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		3 GLU A  70
THR A  69
LEU A  23
 None
 0.67A 1v8bC-3b02A:
undetectable		 1v8bC-3b02A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dx5 UNCHARACTERIZED
PROTEIN ASBF

(Bacillus
anthracis) 		PF01261
(AP_endonuc_2) 		3 GLU A  53
THR A  50
LEU A  34
 None
 0.44A 1v8bC-3dx5A:
undetectable		 1v8bC-3dx5A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0g LEUKEMIA INHIBITORY
FACTOR RECEPTOR

(Homo sapiens) 		PF00041
(fn3) 		3 GLU A 463
THR A 464
LEU A 295
 NAG  A 489 (-4.2A)
None
None
 0.64A 1v8bC-3e0gA:
undetectable		 1v8bC-3e0gA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3guz PANTOTHENATE
SYNTHETASE

(Escherichia
coli) 		PF02569
(Pantoate_ligase) 		3 GLU A 104
THR A 103
LEU A  68
 None
 0.70A 1v8bC-3guzA:
2.1		 1v8bC-3guzA:
16.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3h9u ADENOSYLHOMOCYSTEINA
SE

(Trypanosoma
brucei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		3 GLU A 155
THR A 156
LEU A 343
 None
NAD  A 438 (-3.8A)
NAD  A 438 (-4.0A)
 0.52A 1v8bC-3h9uA:
55.3		 1v8bC-3h9uA:
51.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i1i HOMOSERINE
O-ACETYLTRANSFERASE

(Bacillus
anthracis) 		PF00561
(Abhydrolase_1) 		3 GLU A  29
THR A  30
LEU A 136
 None
 0.70A 1v8bC-3i1iA:
4.3		 1v8bC-3i1iA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ita D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACC

(Escherichia
coli) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		3 GLU A 260
THR A 261
LEU A  27
 None
 0.68A 1v8bC-3itaA:
undetectable		 1v8bC-3itaA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kky SUPEROXIDE DISMUTASE
[MN]

(Deinococcus
radiodurans) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		3 GLU A  46
THR A  45
LEU A  70
 None
 0.52A 1v8bC-3kkyA:
undetectable		 1v8bC-3kkyA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ktd PREPHENATE
DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF02153
(PDH) 		3 GLU A 205
THR A 206
LEU A 255
 None
 0.70A 1v8bC-3ktdA:
3.9		 1v8bC-3ktdA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3led 3-OXOACYL-ACYL
CARRIER PROTEIN
SYNTHASE III

(Rhodopseudomonas
palustris) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		3 GLU A 184
THR A 330
LEU A  11
 None
 0.72A 1v8bC-3ledA:
undetectable		 1v8bC-3ledA:
21.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n58 ADENOSYLHOMOCYSTEINA
SE

(Brucella
abortus) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		3 GLU A 192
THR A 193
LEU A 378
 ADN  A 500 (-3.6A)
NAD  A 550 ( 3.0A)
NAD  A 550 (-4.3A)
 0.61A 1v8bC-3n58A:
57.8		 1v8bC-3n58A:
54.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3one ADENOSYLHOMOCYSTEINA
SE

(Lupinus luteus) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		3 GLU A 205
THR A 206
LEU A 395
 None
NAD  A 501 (-2.8A)
NAD  A 501 (-4.2A)
 0.38A 1v8bC-3oneA:
58.1		 1v8bC-3oneA:
57.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9s CARNITINYL-COA
DEHYDRATASE

(Mycobacterium
avium) 		PF00378
(ECH_1) 		3 GLU A 114
THR A 113
LEU A 161
 BEZ  A 264 (-2.6A)
None
None
 0.66A 1v8bC-3r9sA:
undetectable		 1v8bC-3r9sA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sgz HYDROXYACID OXIDASE
2

(Rattus
norvegicus) 		PF01070
(FMN_dh) 		3 GLU A  36
THR A  33
LEU A 226
 None
 0.69A 1v8bC-3sgzA:
undetectable		 1v8bC-3sgzA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vyg THIOCYANATE
HYDROLASE SUBUNIT
ALPHA

(Thiobacillus
thioparus) 		PF02211
(NHase_beta) 		3 GLU A 115
THR A 116
LEU A 101
 None
 0.72A 1v8bC-3vygA:
undetectable		 1v8bC-3vygA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wqu CELL DIVISION
PROTEIN FTSA

(Staphylococcus
aureus) 		PF02491
(SHS2_FTSA)
PF14450
(FtsA) 		3 GLU A  84
THR A  83
LEU A 222
 None
 0.66A 1v8bC-3wquA:
undetectable		 1v8bC-3wquA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zmr CELLULASE (GLYCOSYL
HYDROLASE FAMILY 5)

(Bacteroides
ovatus) 		PF00150
(Cellulase)
PF13004
(BACON) 		3 GLU A 182
THR A 166
LEU A 194
 None
 0.69A 1v8bC-3zmrA:
undetectable		 1v8bC-3zmrA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ae0 DIPHTHERIA TOXIN

(Corynebacterium
diphtheriae) 		PF01324
(Diphtheria_R)
PF02763
(Diphtheria_C)
PF02764
(Diphtheria_T) 		3 GLU A 168
THR A 169
LEU A 163
 None
 0.69A 1v8bC-4ae0A:
undetectable		 1v8bC-4ae0A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fys AMINOPEPTIDASE N

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		3 GLU A 742
THR A 737
LEU A 792
 None
 0.46A 1v8bC-4fysA:
undetectable		 1v8bC-4fysA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hqe TRANSCRIPTIONAL
REGULATOR QSRR

(Staphylococcus
aureus) 		PF01638
(HxlR) 		3 GLU A  10
THR A  11
LEU A  64
 None
 0.69A 1v8bC-4hqeA:
undetectable		 1v8bC-4hqeA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igl YENB

(Yersinia
entomophaga) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		3 GLU A1174
THR A1175
LEU A1197
 None
 0.70A 1v8bC-4iglA:
undetectable		 1v8bC-4iglA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ij3 HEAVY CHAIN OF FAB
FRAGMENT

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 GLU C 196
THR C 192
LEU C 164
 None
 0.71A 1v8bC-4ij3C:
undetectable		 1v8bC-4ij3C:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jlv C-TERMINAL FRAGMENT
OF MEMBRANE PROTEIN
CAPA1, PUTATIVE
UNCHARACTERIZED
PROTEIN CAPB1

(Staphylococcus
aureus) 		PF13614
(AAA_31) 		3 GLU A1109
THR A1105
LEU A1122
 None
 0.67A 1v8bC-4jlvA:
2.4		 1v8bC-4jlvA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kcd GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 3A

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		3 GLU A 155
THR A 154
LEU A 164
 None
 0.70A 1v8bC-4kcdA:
undetectable		 1v8bC-4kcdA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgl GLYCINE
DEHYDROGENASE
[DECARBOXYLATING]

(Synechocystis
sp. PCC 6803) 		PF02347
(GDC-P) 		3 GLU A 446
THR A 447
LEU A 295
 None
 0.72A 1v8bC-4lglA:
4.3		 1v8bC-4lglA:
19.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lvc S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE)

(Bradyrhizobium
elkanii) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		3 GLU A 197
THR A 198
LEU A 383
 ADN  A 501 (-3.6A)
NAD  A 503 ( 2.9A)
NAD  A 503 ( 3.9A)
 0.13A 1v8bC-4lvcA:
60.5		 1v8bC-4lvcA:
53.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mrp ABC TRANSPORTER
RELATED PROTEIN

(Novosphingobium
aromaticivorans) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		3 GLU A 490
THR A 489
LEU A 498
 None
 0.63A 1v8bC-4mrpA:
undetectable		 1v8bC-4mrpA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nof POLYMERIC
IMMUNOGLOBULIN
RECEPTOR

(Mus musculus) 		PF07686
(V-set) 		3 GLU A 181
THR A 180
LEU A 175
 None
 0.61A 1v8bC-4nofA:
undetectable		 1v8bC-4nofA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p3c HEAVY CHAIN FAB
FRAGMENT OF ANTIBODY
LEM-2/15

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 GLU H 196
THR H 192
LEU H 164
 None
 0.61A 1v8bC-4p3cH:
undetectable		 1v8bC-4p3cH:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0g PROBABLE
ACETYL-/PROPIONYL-CO
A CARBOXYLASE (BETA
SUBUNIT) ACCD1

(Mycobacterium
tuberculosis) 		PF01039
(Carboxyl_trans) 		3 GLU A  66
THR A  87
LEU A 492
 None
 0.61A 1v8bC-4q0gA:
2.4		 1v8bC-4q0gA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qt9 PUTATIVE
GLUCOAMYLASE

(Bacteroides
caccae) 		PF10091
(Glycoamylase) 		3 GLU A 285
THR A 284
LEU A 319
 None
 0.70A 1v8bC-4qt9A:
undetectable		 1v8bC-4qt9A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2x ENDO-BETA-1,4-GLUCAN
ASE (CELLULASE B)

(Bacillus
halodurans) 		PF00150
(Cellulase)
PF03442
(CBM_X2) 		3 GLU A  59
THR A  51
LEU A  71
 None
 0.59A 1v8bC-4v2xA:
2.4		 1v8bC-4v2xA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ww5 EKC/KEOPS COMPLEX
SUBUNIT CGI121

(Saccharomyces
cerevisiae) 		PF08617
(CGI-121) 		3 GLU B  77
THR B  60
LEU B 107
 None
 0.70A 1v8bC-4ww5B:
undetectable		 1v8bC-4ww5B:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wyq RISC-LOADING COMPLEX
SUBUNIT TARBP2

(Homo sapiens) 		PF16482
(Staufen_C) 		3 GLU B 328
THR B 335
LEU B 298
 None
 0.71A 1v8bC-4wyqB:
undetectable		 1v8bC-4wyqB:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x81 MYCINAMICIN III
3''-O-METHYLTRANSFER
ASE

(Micromonospora
griseorubida) 		PF05711
(TylF) 		3 GLU A  83
THR A  84
LEU A 183
 SAH  A 301 (-3.0A)
None
None
 0.60A 1v8bC-4x81A:
4.1		 1v8bC-4x81A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9n L-ALPHA-GLYCEROPHOSP
HATE OXIDASE

(Mycoplasma
pneumoniae) 		PF01266
(DAO) 		3 GLU A  21
THR A  18
LEU A 365
 None
 0.70A 1v8bC-4x9nA:
2.9		 1v8bC-4x9nA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpx ATP-DEPENDENT
PROTEASE LON

(Thermococcus
onnurineus) 		PF01078
(Mg_chelatase)
PF13654
(AAA_32) 		3 GLU A 284
THR A 283
LEU A 185
 None
 0.66A 1v8bC-4zpxA:
undetectable		 1v8bC-4zpxA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zrs ESTERASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		3 GLU A 273
THR A 272
LEU A   5
 None
 0.57A 1v8bC-4zrsA:
5.1		 1v8bC-4zrsA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zv7 LIPASE B

(Moesziomyces
antarcticus) 		no annotation 3 GLU A  81
THR A  80
LEU A 163
 None
 0.66A 1v8bC-4zv7A:
undetectable		 1v8bC-4zv7A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 GLU A 384
THR A 383
LEU A 405
 None
 0.70A 1v8bC-5ahkA:
undetectable		 1v8bC-5ahkA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5r GASDERMIN-A3

(Mus musculus) 		PF04598
(Gasdermin) 		3 GLU A 354
THR A 353
LEU A 181
 None
 0.57A 1v8bC-5b5rA:
undetectable		 1v8bC-5b5rA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ccx TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
NON-CATALYTIC
SUBUNIT TRM6

(Homo sapiens) 		PF04189
(Gcd10p) 		3 GLU B 207
THR B 208
LEU B 383
 None
 0.58A 1v8bC-5ccxB:
4.6		 1v8bC-5ccxB:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e0c CELLULASE

(Bacillus sp.
BG-CS10) 		PF00150
(Cellulase)
PF03442
(CBM_X2) 		3 GLU A  34
THR A  26
LEU A  46
 None
 0.61A 1v8bC-5e0cA:
undetectable		 1v8bC-5e0cA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i10 PROBABLE
O-METHYLTRANSFERASE

(Saccharopolyspora
spinosa) 		PF05711
(TylF) 		3 GLU A  81
THR A  82
LEU A 179
 None
 0.67A 1v8bC-5i10A:
2.0		 1v8bC-5i10A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j7r PUTATIVE LIPOPROTEIN

(Clostridium
perfringens) 		PF10646
(Germane) 		3 GLU A 120
THR A 101
LEU A 162
 None
 0.67A 1v8bC-5j7rA:
undetectable		 1v8bC-5j7rA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jm7 AEROBACTIN SYNTHASE
IUCA

(Klebsiella
pneumoniae) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		3 GLU A 504
THR A 493
LEU A 569
 None
 0.72A 1v8bC-5jm7A:
undetectable		 1v8bC-5jm7A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8g ANTIFREEZE PROTEIN

(Marinomonas
primoryensis) 		no annotation 3 GLU A 409
THR A 408
LEU A 500
 None
CA  A 616 (-3.7A)
None
 0.58A 1v8bC-5k8gA:
undetectable		 1v8bC-5k8gA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l75 FIG000988: PREDICTED
PERMEASE

(Klebsiella
pneumoniae) 		PF03739
(YjgP_YjgQ) 		3 GLU F  10
THR F  75
LEU F 105
 None
 0.68A 1v8bC-5l75F:
undetectable		 1v8bC-5l75F:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5naq BETA-GALACTOSIDASE

(Lactobacillus
plantarum) 		PF00232
(Glyco_hydro_1) 		3 GLU A  20
THR A  19
LEU A  73
 None
 0.51A 1v8bC-5naqA:
undetectable		 1v8bC-5naqA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ovo ADP-RIBOSYL-(DINITRO
GEN REDUCTASE)
HYDROLASE

(Azospirillum
brasilense) 		no annotation 3 GLU A  63
THR A  62
LEU A 272
 None
 0.65A 1v8bC-5ovoA:
undetectable		 1v8bC-5ovoA:
19.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5utu ADENOSYLHOMOCYSTEINA
SE

(Cryptosporidium
parvum) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		3 GLU A 211
THR A 212
LEU A 401
 SAH  A 502 (-3.8A)
NAD  A 501 ( 4.1A)
NAD  A 501 (-4.1A)
 0.50A 1v8bC-5utuA:
56.1		 1v8bC-5utuA:
52.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE

(Naegleria
fowleri) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		3 GLU A 197
THR A 198
LEU A 386
 ADN  A 502 (-3.5A)
NAD  A 501 ( 2.9A)
NAD  A 501 (-3.9A)
 0.18A 1v8bC-5v96A:
61.0		 1v8bC-5v96A:
55.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vae ACCESSORY SEC SYSTEM
PROTEIN ASP1

(Streptococcus
gordonii) 		no annotation 3 GLU A  73
THR A  72
LEU A  53
 None
 0.62A 1v8bC-5vaeA:
4.6		 1v8bC-5vaeA:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vl1 LYSINE--TRNA LIGASE

(Mycobacterium
ulcerans) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		3 GLU A 271
THR A 468
LEU A 190
 LYS  A 502 (-3.3A)
None
None
 0.67A 1v8bC-5vl1A:
undetectable		 1v8bC-5vl1A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4a P-GRANULE SCAFFOLD

(Caenorhabditis
japonica) 		no annotation 3 GLU A 159
THR A 147
LEU A 181
 None
 0.67A 1v8bC-5w4aA:
undetectable		 1v8bC-5w4aA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yww NUCLEOTIDE BINDING
PROTEIN PINC

(Sulfolobus
islandicus) 		no annotation 3 GLU A 134
THR A 135
LEU A 161
 None
 0.61A 1v8bC-5ywwA:
undetectable		 1v8bC-5ywwA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z9y THIAZOLE SYNTHASE

(Mycobacterium
tuberculosis) 		no annotation 3 GLU A  40
THR A  39
LEU A  61
 None
 0.71A 1v8bC-5z9yA:
2.8		 1v8bC-5z9yA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aqh LYSINE--TRNA LIGASE

(Mycolicibacterium
thermoresistibile) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		3 GLU A 274
THR A 472
LEU A 193
 LYS  A 601 (-3.5A)
None
None
 0.61A 1v8bC-6aqhA:
undetectable		 1v8bC-6aqhA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bm7 INACTIVE
S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROZYME

(Trypanosoma
brucei) 		no annotation 3 GLU E 249
THR E 250
LEU E 266
 None
 0.70A 1v8bC-6bm7E:
undetectable		 1v8bC-6bm7E:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bzy 22D11 HEAVY CHAIN

(Mus musculus) 		no annotation 3 GLU H 192
THR H 188
LEU H 159
 None
 0.61A 1v8bC-6bzyH:
undetectable		 1v8bC-6bzyH:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6etz BETA-GALACTOSIDASE

(Arthrobacter
sp. 32cB) 		no annotation 3 GLU A 393
THR A 394
LEU A 448
 None
 0.71A 1v8bC-6etzA:
undetectable		 1v8bC-6etzA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3m -

(-) 		no annotation 3 GLU B 164
THR B 165
LEU B 373
 ADN  B 502 (-3.6A)
NAD  B 501 ( 2.8A)
NAD  B 501 ( 3.9A)
 0.22A 1v8bC-6f3mB:
50.6		 1v8bC-6f3mB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fkh ATP SYNTHASE SUBUNIT
ALPHA, CHLOROPLASTIC

(Spinacia
oleracea) 		no annotation 3 GLU C 321
THR C 322
LEU C 167
 None
 0.72A 1v8bC-6fkhC:
undetectable		 1v8bC-6fkhC:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gbn -

(-) 		no annotation 3 GLU A 159
THR A 160
LEU A 347
 ADN  A 501 (-3.9A)
NAD  A 502 ( 2.8A)
NAD  A 502 (-3.9A)
 0.21A 1v8bC-6gbnA:
27.0		 1v8bC-6gbnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gqd GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE

(Homo sapiens) 		no annotation 3 GLU A 159
THR A 158
LEU A 318
 None
 0.72A 1v8bC-6gqdA:
undetectable		 1v8bC-6gqdA:
undetectable