SIMILAR PATTERNS OF AMINO ACIDS FOR 1V8B_C_ADNC2502

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fi8 NATURAL KILLER CELL
PROTEASE 1

(Rattus
norvegicus) 		PF00089
(Trypsin) 		5 LEU A 160
THR A 224
ASP A 194
GLY A 220
PHE A 228
 None
 1.20A 1v8bC-1fi8A:
undetectable		 1v8bC-1fi8A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0v PROTEINASE A

(Saccharomyces
cerevisiae) 		PF00026
(Asp) 		5 HIS A   2
THR A 166
GLU A 164
ASP A  93
GLY A   0
 None
 1.42A 1v8bC-1g0vA:
undetectable		 1v8bC-1g0vA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g7r TRANSLATION
INITIATION FACTOR
IF2/EIF5B

(Methanothermobacter
thermautotrophicus) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2)
PF14578
(GTP_EFTU_D4) 		5 LEU A 161
ASP A 162
ASP A 183
MET A 147
PHE A 146
 None
 1.22A 1v8bC-1g7rA:
2.2		 1v8bC-1g7rA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gju MALTODEXTRIN
GLYCOSYLTRANSFERASE

(Thermotoga
maritima) 		PF00128
(Alpha-amylase)
PF09083
(DUF1923) 		5 LEU A 335
HIS A 327
GLU A 329
ASP A 346
GLY A 355
 None
 1.32A 1v8bC-1gjuA:
undetectable		 1v8bC-1gjuA:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3e TYROSYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00579
(tRNA-synt_1b) 		5 LEU A 269
LEU A 243
GLY A 242
HIS A  52
MET A 233
 None
None
None
ATP  A1433 (-4.3A)
None
 1.36A 1v8bC-1h3eA:
undetectable		 1v8bC-1h3eA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzv HYPOTHETICAL PROTEIN

(Trypanosoma
cruzi) 		PF00857
(Isochorismatase) 		5 LEU A  44
THR A  13
ASP A 178
GLY A   9
HIS A   7
 None
 1.48A 1v8bC-1yzvA:
3.3		 1v8bC-1yzvA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9n SUPEROXIDE DISMUTASE
[CU-ZN]

([Haemophilus]
ducreyi) 		PF00080
(Sod_Cu) 		5 HIS A 113
GLU A  73
ASP A 116
GLY A  94
HIS A  72
 ZN  A 201 (-3.1A)
None
ZN  A 201 (-2.1A)
None
CU  A 200 (-3.2A)
 1.28A 1v8bC-1z9nA:
undetectable		 1v8bC-1z9nA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9p SUPEROXIDE DISMUTASE
[CU-ZN]

([Haemophilus]
ducreyi) 		PF00080
(Sod_Cu) 		5 HIS A 113
GLU A  73
ASP A 116
GLY A  94
HIS A  72
 ZN  A 201 (-3.1A)
None
ZN  A 201 (-2.2A)
None
CU  A 200 (-3.2A)
 1.26A 1v8bC-1z9pA:
undetectable		 1v8bC-1z9pA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9v GMP SYNTHASE

(Thermoplasma
acidophilum) 		PF00117
(GATase) 		5 LEU A  77
GLU A  17
GLY A  50
HIS A 167
PHE A 180
 None
 1.14A 1v8bC-2a9vA:
4.4		 1v8bC-2a9vA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eh0 KINESIN-LIKE PROTEIN
KIF1B

(Homo sapiens) 		PF00498
(FHA)
PF16183
(Kinesin_assoc) 		5 LEU A  11
LEU A  48
GLY A  36
HIS A  57
PHE A  60
 None
 1.33A 1v8bC-2eh0A:
undetectable		 1v8bC-2eh0A:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g1l KINESIN-LIKE PROTEIN
KIF1C

(Homo sapiens) 		PF00498
(FHA)
PF16183
(Kinesin_assoc) 		5 LEU A 501
LEU A 534
GLY A 526
HIS A 543
PHE A 546
 None
 1.19A 1v8bC-2g1lA:
undetectable		 1v8bC-2g1lA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hfq HYPOTHETICAL PROTEIN

(Nitrosomonas
europaea) 		PF09630
(DUF2024) 		5 LEU A  40
LYS A  80
GLY A  15
HIS A  16
MET A  18
 None
 1.19A 1v8bC-2hfqA:
undetectable		 1v8bC-2hfqA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hp3 IDS-EPIMERASE

(Agrobacterium
tumefaciens) 		PF03972
(MmgE_PrpD) 		5 LEU A 263
ASP A  91
LEU A 104
GLY A 159
MET A  96
 None
 1.32A 1v8bC-2hp3A:
undetectable		 1v8bC-2hp3A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w61 GLYCOLIPID-ANCHORED
SURFACE PROTEIN 2

(Saccharomyces
cerevisiae) 		PF03198
(Glyco_hydro_72)
PF07983
(X8) 		5 LEU A 169
THR A 103
LEU A 305
GLY A 304
PHE A  52
 None
 1.43A 1v8bC-2w61A:
undetectable		 1v8bC-2w61A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3azq AMINOPEPTIDASE

(Streptomyces
morookaense) 		PF00326
(Peptidase_S9) 		5 THR A 531
ASP A 445
LEU A 533
GLY A 509
PHE A 449
 None
 1.32A 1v8bC-3azqA:
undetectable		 1v8bC-3azqA:
21.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ce6 ADENOSYLHOMOCYSTEINA
SE

(Mycobacterium
tuberculosis) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		11 LEU A  68
HIS A  69
THR A  71
ASP A 156
LYS A 248
ASP A 252
LEU A 410
GLY A 415
HIS A 416
MET A 421
PHE A 425
 None
ADN  A 500 (-4.0A)
ADN  A 500 (-2.8A)
ADN  A 500 (-2.9A)
ADN  A 500 (-2.8A)
ADN  A 500 (-2.7A)
ADN  A 500 ( 4.8A)
ADN  A 500 ( 3.6A)
ADN  A 500 ( 3.6A)
ADN  A 500 (-3.7A)
ADN  A 500 (-4.8A)
 0.29A 1v8bC-3ce6A:
59.4		 1v8bC-3ce6A:
54.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE

(Alvinella
pompejana) 		PF00080
(Sod_Cu) 		5 HIS A  78
GLU A  47
ASP A  81
GLY A  60
HIS A  46
 ZN  A 203 (-3.1A)
SO4  A 209 (-3.4A)
ZN  A 203 (-2.2A)
None
CU1  A 201 ( 3.1A)
 1.26A 1v8bC-3f7lA:
undetectable		 1v8bC-3f7lA:
16.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g1u ADENOSYLHOMOCYSTEINA
SE

(Leishmania
major) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		9 LEU A  51
HIS A  52
THR A  54
ASP A 130
LEU A 346
GLY A 351
HIS A 352
MET A 357
PHE A 361
 None
ADN  A 438 (-4.0A)
ADN  A 438 (-2.8A)
ADN  A 438 (-4.1A)
ADN  A 438 ( 4.8A)
ADN  A 438 ( 3.8A)
ADN  A 438 ( 3.6A)
ADN  A 438 (-3.7A)
None
 0.55A 1v8bC-3g1uA:
55.2		 1v8bC-3g1uA:
51.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3glq ADENOSYLHOMOCYSTEINA
SE

(Burkholderia
pseudomallei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		6 LEU A  61
ASP A 139
LYS A 229
ASP A 233
LEU A 385
HIS A 394
 None
RAB  A 602 (-3.0A)
RAB  A 602 (-3.0A)
RAB  A 602 (-2.5A)
NAD  A 601 ( 4.1A)
NAD  A 601 ( 3.6A)
 1.23A 1v8bC-3glqA:
57.5		 1v8bC-3glqA:
51.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3glq ADENOSYLHOMOCYSTEINA
SE

(Burkholderia
pseudomallei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		11 LEU A  61
HIS A  62
THR A  64
ASP A 139
LYS A 229
ASP A 233
LEU A 388
GLY A 393
HIS A 394
MET A 399
PHE A 403
 None
RAB  A 602 (-3.8A)
RAB  A 602 (-2.7A)
RAB  A 602 (-3.0A)
RAB  A 602 (-3.0A)
RAB  A 602 (-2.5A)
RAB  A 602 ( 4.7A)
RAB  A 602 ( 3.8A)
NAD  A 601 ( 3.6A)
RAB  A 602 (-3.6A)
None
 0.31A 1v8bC-3glqA:
57.5		 1v8bC-3glqA:
51.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3e UNCHARACTERIZED
PROTEIN TM1679

(Thermotoga
maritima) 		PF00753
(Lactamase_B) 		5 LEU A 198
HIS A 196
ASP A   9
GLY A 194
HIS A 224
 None
 1.31A 1v8bC-3h3eA:
2.3		 1v8bC-3h3eA:
21.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3h9u ADENOSYLHOMOCYSTEINA
SE

(Trypanosoma
brucei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		6 HIS A  52
ASP A 130
LYS A 185
ASP A 189
LEU A 343
HIS A 352
 ADN  A 439 ( 4.7A)
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 3.3A)
 1.42A 1v8bC-3h9uA:
55.3		 1v8bC-3h9uA:
51.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3h9u ADENOSYLHOMOCYSTEINA
SE

(Trypanosoma
brucei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		11 LEU A  51
HIS A  52
THR A  54
ASP A 130
LYS A 185
ASP A 189
LEU A 346
GLY A 351
HIS A 352
MET A 357
PHE A 361
 None
ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.28A 1v8bC-3h9uA:
55.3		 1v8bC-3h9uA:
51.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n58 ADENOSYLHOMOCYSTEINA
SE

(Brucella
abortus) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		6 LEU A  54
ASP A 132
LYS A 222
ASP A 226
LEU A 378
HIS A 387
 None
ADN  A 500 (-3.3A)
ADN  A 500 (-2.7A)
ADN  A 500 ( 2.6A)
NAD  A 550 (-4.3A)
ADN  A 500 (-3.4A)
 1.20A 1v8bC-3n58A:
57.8		 1v8bC-3n58A:
54.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n58 ADENOSYLHOMOCYSTEINA
SE

(Brucella
abortus) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		11 LEU A  54
HIS A  55
THR A  57
ASP A 132
LYS A 222
ASP A 226
LEU A 381
GLY A 386
HIS A 387
MET A 392
PHE A 396
 None
ADN  A 500 (-4.0A)
ADN  A 500 (-2.8A)
ADN  A 500 (-3.3A)
ADN  A 500 (-2.7A)
ADN  A 500 ( 2.6A)
ADN  A 500 ( 4.8A)
ADN  A 500 (-3.7A)
ADN  A 500 (-3.4A)
ADN  A 500 (-3.7A)
None
 0.27A 1v8bC-3n58A:
57.8		 1v8bC-3n58A:
54.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3one ADENOSYLHOMOCYSTEINA
SE

(Lupinus luteus) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		6 HIS A  62
ASP A 139
LYS A 235
ASP A 239
LEU A 395
HIS A 404
 ADE  A 506 (-4.6A)
None
NAD  A 501 ( 4.2A)
NAD  A 501 ( 4.5A)
NAD  A 501 (-4.2A)
ADE  A 506 (-3.4A)
 1.41A 1v8bC-3oneA:
58.1		 1v8bC-3oneA:
57.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3one ADENOSYLHOMOCYSTEINA
SE

(Lupinus luteus) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		11 LEU A  61
HIS A  62
THR A  64
ASP A 139
LYS A 235
ASP A 239
LEU A 398
GLY A 403
HIS A 404
MET A 409
PHE A 413
 None
ADE  A 506 (-4.6A)
ADE  A 506 (-2.8A)
None
NAD  A 501 ( 4.2A)
NAD  A 501 ( 4.5A)
ADE  A 506 ( 4.7A)
ADE  A 506 ( 3.6A)
ADE  A 506 (-3.4A)
ADE  A 506 (-3.8A)
ADE  A 506 (-4.9A)
 0.59A 1v8bC-3oneA:
58.1		 1v8bC-3oneA:
57.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pf7 BENZOYL-COA
OXYGENASE COMPONENT
B

(Azoarcus
evansii) 		no annotation 5 LEU A 427
HIS A 423
LYS A 398
HIS A 406
PHE A 395
 None
 0.90A 1v8bC-3pf7A:
undetectable		 1v8bC-3pf7A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tad LIPRIN-BETA-1

(Mus musculus) 		PF00536
(SAM_1)
PF07647
(SAM_2) 		5 LEU C 726
HIS C 727
LEU C 692
GLY C 691
HIS C 793
 None
 1.47A 1v8bC-3tadC:
undetectable		 1v8bC-3tadC:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cw4 BETA-KETOACYL
SYNTHASE

(Pseudomonas
aeruginosa) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 HIS A  23
ASP A 581
ASP A 196
GLY A  17
PHE A  10
 None
 1.22A 1v8bC-4cw4A:
undetectable		 1v8bC-4cw4A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cw4 BETA-KETOACYL
SYNTHASE

(Pseudomonas
aeruginosa) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 HIS A  23
ASP A 581
ASP A 196
GLY A  24
PHE A  10
 None
 1.49A 1v8bC-4cw4A:
undetectable		 1v8bC-4cw4A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4egx KINESIN-LIKE PROTEIN
KIF1A

(Homo sapiens) 		PF00498
(FHA)
PF16183
(Kinesin_assoc) 		5 LEU A 494
LEU A 531
GLY A 519
HIS A 540
PHE A 543
 None
 1.20A 1v8bC-4egxA:
undetectable		 1v8bC-4egxA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ejq KINESIN-LIKE PROTEIN
KIF1A

(Homo sapiens) 		PF00498
(FHA)
PF16183
(Kinesin_assoc) 		5 LEU A 494
LEU A 531
GLY A 519
HIS A 540
PHE A 543
 None
 1.12A 1v8bC-4ejqA:
undetectable		 1v8bC-4ejqA:
15.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lvc S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE)

(Bradyrhizobium
elkanii) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		6 HIS A  58
ASP A 135
LYS A 227
ASP A 231
LEU A 383
HIS A 392
 ADN  A 501 (-4.0A)
ADN  A 501 (-3.0A)
ADN  A 501 (-2.7A)
ADN  A 501 (-3.1A)
NAD  A 503 ( 3.9A)
ADN  A 501 (-3.5A)
 1.46A 1v8bC-4lvcA:
60.5		 1v8bC-4lvcA:
53.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lvc S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE)

(Bradyrhizobium
elkanii) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		11 LEU A  57
HIS A  58
THR A  60
ASP A 135
LYS A 227
ASP A 231
LEU A 386
GLY A 391
HIS A 392
MET A 397
PHE A 401
 None
ADN  A 501 (-4.0A)
ADN  A 501 (-2.8A)
ADN  A 501 (-3.0A)
ADN  A 501 (-2.7A)
ADN  A 501 (-3.1A)
ADN  A 501 ( 4.7A)
ADN  A 501 (-3.6A)
ADN  A 501 (-3.5A)
ADN  A 501 (-3.7A)
ADN  A 501 (-4.8A)
 0.29A 1v8bC-4lvcA:
60.5		 1v8bC-4lvcA:
53.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mo9 PERIPLASMIC BINDING
PROTEIN

(Veillonella
parvula) 		PF01497
(Peripla_BP_2) 		5 ASP A  77
LEU A 314
GLY A 313
MET A  78
PHE A  82
 None
 1.28A 1v8bC-4mo9A:
undetectable		 1v8bC-4mo9A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE

(Thermococcus
kodakarensis) 		PF00562
(RNA_pol_Rpb2_6)
PF00623
(RNA_pol_Rpb1_2)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		5 LEU B1073
HIS A  73
LYS B1102
ASP B1106
GLY A  75
 None
ZN  A1002 (-3.1A)
None
None
None
 1.33A 1v8bC-4qiwB:
undetectable		 1v8bC-4qiwB:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bqs 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Streptococcus
pneumoniae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 THR A  80
GLU A 140
ASP A  84
LEU A  78
GLY A 138
 None
 1.32A 1v8bC-5bqsA:
undetectable		 1v8bC-5bqsA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF09334
(tRNA-synt_1g) 		5 GLU A 402
ASP A 416
ASP A 419
LEU A 430
GLY A 403
 None
 1.44A 1v8bC-5gl7A:
3.1		 1v8bC-5gl7A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jiu RAN-BINDING PROTEIN
9

(Homo sapiens) 		PF00622
(SPRY) 		5 HIS A 255
ASP A 258
LEU A 244
GLY A 317
PHE A 275
 None
 1.39A 1v8bC-5jiuA:
undetectable		 1v8bC-5jiuA:
18.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5utu ADENOSYLHOMOCYSTEINA
SE

(Cryptosporidium
parvum) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		6 HIS A  53
ASP A 137
LYS A 241
ASP A 245
LEU A 401
HIS A 410
 SAH  A 502 (-4.0A)
SAH  A 502 (-3.4A)
SAH  A 502 (-2.9A)
SAH  A 502 (-2.8A)
NAD  A 501 (-4.1A)
SAH  A 502 ( 3.5A)
 1.46A 1v8bC-5utuA:
56.1		 1v8bC-5utuA:
52.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5utu ADENOSYLHOMOCYSTEINA
SE

(Cryptosporidium
parvum) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		12 LEU A  52
HIS A  53
THR A  55
GLU A  57
ASP A 137
LYS A 241
ASP A 245
LEU A 404
GLY A 409
HIS A 410
MET A 415
PHE A 419
 None
SAH  A 502 (-4.0A)
SAH  A 502 (-2.7A)
SAH  A 502 (-3.7A)
SAH  A 502 (-3.4A)
SAH  A 502 (-2.9A)
SAH  A 502 (-2.8A)
SAH  A 502 ( 4.7A)
SAH  A 502 ( 3.7A)
SAH  A 502 ( 3.5A)
SAH  A 502 (-3.6A)
SAH  A 502 (-4.8A)
 0.21A 1v8bC-5utuA:
56.1		 1v8bC-5utuA:
52.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE

(Naegleria
fowleri) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		6 HIS A  59
ASP A 136
LYS A 227
ASP A 231
LEU A 386
HIS A 395
 ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 3.4A)
 1.47A 1v8bC-5v96A:
61.0		 1v8bC-5v96A:
55.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE

(Naegleria
fowleri) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		12 LEU A  58
HIS A  59
THR A  61
GLU A  63
ASP A 136
LYS A 227
ASP A 231
LEU A 389
GLY A 394
HIS A 395
MET A 400
PHE A 404
 None
ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.6A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.26A 1v8bC-5v96A:
61.0		 1v8bC-5v96A:
55.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w4b ADENOSYLHOMOCYSTEINA
SE

(Homo sapiens) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		9 LEU A  54
HIS A  55
GLU A  59
ASP A 131
LYS A 186
ASP A 190
HIS A 353
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-3.8A)
None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.89A 1v8bC-5w4bA:
46.5		 1v8bC-5w4bA:
51.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w4b ADENOSYLHOMOCYSTEINA
SE

(Homo sapiens) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		9 LEU A  54
HIS A  55
THR A  57
GLU A  59
ASP A 131
LYS A 186
ASP A 190
MET A 358
PHE A 362
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
9W4  A 502 (-3.8A)
None
None
NAD  A 501 (-4.1A)
9W4  A 502 (-3.6A)
None
 0.69A 1v8bC-5w4bA:
46.5		 1v8bC-5w4bA:
51.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w4b ADENOSYLHOMOCYSTEINA
SE

(Homo sapiens) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		6 LYS A 186
ASP A 190
GLY A 352
HIS A 353
MET A 358
PHE A 362
 None
NAD  A 501 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
None
 0.89A 1v8bC-5w4bA:
46.5		 1v8bC-5w4bA:
51.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w4b ADENOSYLHOMOCYSTEINA
SE

(Homo sapiens) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		6 LYS A 186
ASP A 190
LEU A 347
GLY A 352
HIS A 353
MET A 358
 None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 0.85A 1v8bC-5w4bA:
46.5		 1v8bC-5w4bA:
51.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN

(Homo sapiens) 		PF00415
(RCC1)
PF13540
(RCC1_2) 		5 LEU A 187
HIS A 185
GLY A 255
HIS A 241
PHE A 244
 None
 1.37A 1v8bC-5xgsA:
undetectable		 1v8bC-5xgsA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yim SDEA

(Legionella
pneumophila) 		no annotation 5 LEU A 571
GLU A 561
ASP A 410
GLY A 278
HIS A 281
 None
 1.44A 1v8bC-5yimA:
undetectable		 1v8bC-5yimA:
9.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6aph ADENOSYLHOMOCYSTEINA
SE

(Elizabethkingia
anophelis) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		6 LEU A  57
ASP A 136
LYS A 191
ASP A 195
LEU A 349
HIS A 358
 None
ADN  A 501 (-3.0A)
ADN  A 501 (-2.8A)
ADN  A 501 (-2.7A)
NAD  A 500 ( 4.3A)
ADN  A 501 ( 3.5A)
 1.26A 1v8bC-6aphA:
55.0		 1v8bC-6aphA:
51.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6aph ADENOSYLHOMOCYSTEINA
SE

(Elizabethkingia
anophelis) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		11 LEU A  57
HIS A  58
THR A  60
ASP A 136
LYS A 191
ASP A 195
LEU A 352
GLY A 357
HIS A 358
MET A 363
PHE A 367
 None
ADN  A 501 (-3.9A)
ADN  A 501 (-2.8A)
ADN  A 501 (-3.0A)
ADN  A 501 (-2.8A)
ADN  A 501 (-2.7A)
ADN  A 501 ( 4.8A)
ADN  A 501 (-3.6A)
ADN  A 501 ( 3.5A)
ADN  A 501 (-3.7A)
None
 0.28A 1v8bC-6aphA:
55.0		 1v8bC-6aphA:
51.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cey BIFUNCTIONAL AAC/APH

(Staphylococcus
aureus) 		no annotation 5 LEU A 247
ASP A 405
GLY A 311
HIS A 310
PHE A 305
 None
 1.42A 1v8bC-6ceyA:
undetectable		 1v8bC-6ceyA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3m -

(-) 		no annotation 6 HIS B  61
ASP B 139
LYS B 194
ASP B 198
LEU B 373
HIS B 382
 ADN  B 502 ( 4.0A)
ZN  B 505 ( 2.5A)
ADN  B 502 (-2.8A)
ADN  B 502 (-2.7A)
NAD  B 501 ( 3.9A)
ADN  B 502 (-3.4A)
 1.43A 1v8bC-6f3mB:
50.6		 1v8bC-6f3mB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3m -

(-) 		no annotation 10 HIS B  61
THR B  63
ASP B 139
LYS B 194
ASP B 198
LEU B 376
GLY B 381
HIS B 382
MET B 387
PHE B 391
 ADN  B 502 ( 4.0A)
ADN  B 502 (-2.8A)
ZN  B 505 ( 2.5A)
ADN  B 502 (-2.8A)
ADN  B 502 (-2.7A)
ADN  B 502 ( 4.8A)
ADN  B 502 ( 3.7A)
ADN  B 502 (-3.4A)
ADN  B 502 (-3.7A)
ADN  B 502 (-4.9A)
 0.36A 1v8bC-6f3mB:
50.6		 1v8bC-6f3mB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gbn -

(-) 		no annotation 6 HIS A  56
ASP A 134
LYS A 189
ASP A 193
LEU A 347
HIS A 356
 ADN  A 501 (-3.9A)
ADN  A 501 (-2.9A)
ADN  A 501 (-2.9A)
ADN  A 501 (-2.7A)
NAD  A 502 (-3.9A)
ADN  A 501 (-3.4A)
 1.44A 1v8bC-6gbnA:
27.0		 1v8bC-6gbnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gbn -

(-) 		no annotation 11 LEU A  55
HIS A  56
THR A  58
ASP A 134
LYS A 189
ASP A 193
LEU A 350
GLY A 355
HIS A 356
MET A 361
PHE A 365
 None
ADN  A 501 (-3.9A)
ADN  A 501 (-2.8A)
ADN  A 501 (-2.9A)
ADN  A 501 (-2.9A)
ADN  A 501 (-2.7A)
ADN  A 501 ( 4.7A)
ADN  A 501 (-3.8A)
ADN  A 501 (-3.4A)
ADN  A 501 (-3.6A)
None
 0.24A 1v8bC-6gbnA:
27.0		 1v8bC-6gbnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cs6 AXONIN-1

(Gallus gallus) 		PF07679
(I-set)
PF13927
(Ig_3) 		3 GLU A 311
THR A 310
LEU A 359
 None
 0.71A 1v8bC-1cs6A:
undetectable		 1v8bC-1cs6A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ecg GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Escherichia
coli) 		PF00156
(Pribosyltran)
PF13522
(GATase_6) 		3 GLU A 203
THR A 202
LEU A 221
 None
 0.72A 1v8bC-1ecgA:
2.4		 1v8bC-1ecgA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1guq GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE

(Escherichia
coli) 		PF01087
(GalP_UDP_transf)
PF02744
(GalP_UDP_tr_C) 		3 GLU A 215
THR A 216
LEU A 235
 None
 0.61A 1v8bC-1guqA:
undetectable		 1v8bC-1guqA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hml ALPHA-LACTALBUMIN

(Homo sapiens) 		PF00062
(Lys) 		3 GLU A  49
THR A  48
LEU A  81
 ZN  A 125 ( 2.1A)
None
None
 0.70A 1v8bC-1hmlA:
undetectable		 1v8bC-1hmlA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
ALPHA SUBUNIT

(Saccharomyces
cerevisiae) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		3 GLU A 120
THR A 121
LEU A  84
 None
 0.71A 1v8bC-1hr7A:
undetectable		 1v8bC-1hr7A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhy METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylosinus
trichosporium) 		PF02332
(Phenol_Hydrox) 		3 GLU B  92
THR B  91
LEU B 306
 None
 0.60A 1v8bC-1mhyB:
undetectable		 1v8bC-1mhyB:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgx PROTEIN G

(Streptococcus) 		PF01378
(IgG_binding_B) 		3 GLU A  28
THR A  29
LEU A  25
 None
 0.66A 1v8bC-1pgxA:
undetectable		 1v8bC-1pgxA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8i DNA POLYMERASE II

(Escherichia
coli) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		3 GLU A 579
THR A 580
LEU A 533
 None
 0.66A 1v8bC-1q8iA:
undetectable		 1v8bC-1q8iA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q90 APOCYTOCHROME F

(Chlamydomonas
reinhardtii) 		PF01333
(Apocytochr_F_C)
PF16639
(Apocytochr_F_N) 		3 GLU A 241
THR A 242
LEU A  75
 None
 0.67A 1v8bC-1q90A:
undetectable		 1v8bC-1q90A:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qav NEURONAL NITRIC
OXIDE SYNTHASE
(RESIDUES 1-130)

(Rattus
norvegicus) 		PF00595
(PDZ) 		3 GLU B1108
THR B1109
LEU B1057
 None
 0.64A 1v8bC-1qavB:
undetectable		 1v8bC-1qavB:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rc7 RIBONUCLEASE III

(Aquifex
aeolicus) 		PF00035
(dsrm)
PF14622
(Ribonucleas_3_3) 		3 GLU A 187
THR A 195
LEU A 156
 None
 0.61A 1v8bC-1rc7A:
undetectable		 1v8bC-1rc7A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sky F1-ATPASE

(Bacillus sp.
PS3) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		3 GLU B 320
THR B 321
LEU B 166
 None
 0.66A 1v8bC-1skyB:
2.5		 1v8bC-1skyB:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tua HYPOTHETICAL PROTEIN
APE0754

(Aeropyrum
pernix) 		PF00013
(KH_1) 		3 GLU A 123
THR A 128
LEU A 169
 None
 0.61A 1v8bC-1tuaA:
undetectable		 1v8bC-1tuaA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9k RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE C

(Escherichia
coli) 		PF00849
(PseudoU_synth_2) 		3 GLU A 217
THR A 218
LEU A 195
 None
 0.65A 1v8bC-1v9kA:
undetectable		 1v8bC-1v9kA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdt ELONGATION FACTOR G
HOMOLOG

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		3 GLU A 116
THR A 115
LEU A 149
 None
 0.63A 1v8bC-1wdtA:
2.2		 1v8bC-1wdtA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x5r GLUTAMATE RECEPTOR
INTERACTING PROTEIN
2

(Homo sapiens) 		PF00595
(PDZ) 		3 GLU A  15
THR A  14
LEU A  71
 None
 0.65A 1v8bC-1x5rA:
undetectable		 1v8bC-1x5rA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yni SUCCINYLARGININE
DIHYDROLASE

(Escherichia
coli) 		PF04996
(AstB) 		3 GLU A 324
THR A 302
LEU A 335
 None
 0.65A 1v8bC-1yniA:
undetectable		 1v8bC-1yniA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq2 BETA-GALACTOSIDASE

(Arthrobacter
sp. C2-2) 		PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		3 GLU A 394
THR A 395
LEU A 449
 None
 0.72A 1v8bC-1yq2A:
2.7		 1v8bC-1yq2A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ash QUEUINE
TRNA-RIBOSYLTRANSFER
ASE

(Thermotoga
maritima) 		PF01702
(TGT) 		3 GLU A 226
THR A 225
LEU A 248
 None
 0.63A 1v8bC-2ashA:
undetectable		 1v8bC-2ashA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c5s PROBABLE THIAMINE
BIOSYNTHESIS PROTEIN
THII

(Bacillus
anthracis) 		PF02568
(ThiI)
PF02926
(THUMP) 		3 GLU A 229
THR A 333
LEU A 184
 None
 0.73A 1v8bC-2c5sA:
2.3		 1v8bC-2c5sA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cbz MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1

(Homo sapiens) 		PF00005
(ABC_tran) 		3 GLU A 760
THR A 759
LEU A 768
 None
 0.70A 1v8bC-2cbzA:
undetectable		 1v8bC-2cbzA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eq9 PYRUVATE
DEHYDROGENASE
COMPLEX,
DIHYDROLIPOAMIDE
DEHYDROGENASE E3
COMPONENT

(Thermus
thermophilus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 GLU A 357
THR A 354
LEU A 212
 None
 0.57A 1v8bC-2eq9A:
4.2		 1v8bC-2eq9A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f4o PEPTIDE N-GLYCANASE

(Mus musculus) 		PF01841
(Transglut_core) 		3 GLU A 337
THR A 336
LEU A 227
 None
 0.72A 1v8bC-2f4oA:
undetectable		 1v8bC-2f4oA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o4c ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
PF11890
(DUF3410) 		3 GLU A  48
THR A  47
LEU A  35
 None
 0.69A 1v8bC-2o4cA:
9.5		 1v8bC-2o4cA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9v ATP SYNTHASE SUBUNIT
ALPHA

(Thermotoga
maritima) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		3 GLU A 321
THR A 322
LEU A 167
 None
 0.71A 1v8bC-2r9vA:
undetectable		 1v8bC-2r9vA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6b L-LACTATE
DEHYDROGENASE

(Deinococcus
radiodurans) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 GLU A 259
THR A 258
LEU A  49
 None
 0.71A 1v8bC-2v6bA:
6.2		 1v8bC-2v6bA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6o THIOREDOXIN
GLUTATHIONE
REDUCTASE

(Schistosoma
mansoni) 		PF00462
(Glutaredoxin)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 GLU A 462
THR A 461
LEU A  53
 None
PG4  A1596 ( 4.8A)
None
 0.72A 1v8bC-2v6oA:
4.2		 1v8bC-2v6oA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrn PROTEASE I

(Deinococcus
radiodurans) 		PF01965
(DJ-1_PfpI) 		3 GLU A 123
THR A 124
LEU A  81
 None
 0.69A 1v8bC-2vrnA:
4.2		 1v8bC-2vrnA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wk1 NOVP

(Actinoalloteichus
cyanogriseus) 		PF05711
(TylF) 		3 GLU A  92
THR A  93
LEU A 190
 SAH  A 301 (-2.9A)
None
None
 0.62A 1v8bC-2wk1A:
4.2		 1v8bC-2wk1A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2woc ADP-RIBOSYL-[DINITRO
GEN REDUCTASE]
GLYCOHYDROLASE

(Rhodospirillum
rubrum) 		PF03747
(ADP_ribosyl_GH) 		3 GLU A  63
THR A  62
LEU A 272
 None
 0.65A 1v8bC-2wocA:
undetectable		 1v8bC-2wocA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2woz KELCH REPEAT AND BTB
DOMAIN-CONTAINING
PROTEIN 10

(Rattus
norvegicus) 		PF01344
(Kelch_1) 		3 GLU A 411
THR A 410
LEU A 414
 None
 0.69A 1v8bC-2wozA:
undetectable		 1v8bC-2wozA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yqu 2-OXOGLUTARATE
DEHYDROGENASE E3
COMPONENT

(Thermus
thermophilus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 GLU A 345
THR A 342
LEU A 203
 None
 0.54A 1v8bC-2yquA:
3.5		 1v8bC-2yquA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3j PBP5

(Haemophilus
influenzae) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		3 GLU A 283
THR A 284
LEU A  52
 None
 0.68A 1v8bC-3a3jA:
undetectable		 1v8bC-3a3jA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afg SUBTILISIN-LIKE
SERINE PROTEASE

(Thermococcus
kodakarensis) 		PF00082
(Peptidase_S8)
PF04151
(PPC) 		3 GLU A 390
THR A 391
LEU A 372
 None
 0.72A 1v8bC-3afgA:
3.7		 1v8bC-3afgA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b02 TRANSCRIPTIONAL
REGULATOR, CRP
FAMILY

(Thermus
thermophilus) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		3 GLU A  70
THR A  69
LEU A  23
 None
 0.67A 1v8bC-3b02A:
undetectable		 1v8bC-3b02A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dx5 UNCHARACTERIZED
PROTEIN ASBF

(Bacillus
anthracis) 		PF01261
(AP_endonuc_2) 		3 GLU A  53
THR A  50
LEU A  34
 None
 0.44A 1v8bC-3dx5A:
undetectable		 1v8bC-3dx5A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0g LEUKEMIA INHIBITORY
FACTOR RECEPTOR

(Homo sapiens) 		PF00041
(fn3) 		3 GLU A 463
THR A 464
LEU A 295
 NAG  A 489 (-4.2A)
None
None
 0.64A 1v8bC-3e0gA:
undetectable		 1v8bC-3e0gA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3guz PANTOTHENATE
SYNTHETASE

(Escherichia
coli) 		PF02569
(Pantoate_ligase) 		3 GLU A 104
THR A 103
LEU A  68
 None
 0.70A 1v8bC-3guzA:
2.1		 1v8bC-3guzA:
16.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3h9u ADENOSYLHOMOCYSTEINA
SE

(Trypanosoma
brucei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		3 GLU A 155
THR A 156
LEU A 343
 None
NAD  A 438 (-3.8A)
NAD  A 438 (-4.0A)
 0.52A 1v8bC-3h9uA:
55.3		 1v8bC-3h9uA:
51.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i1i HOMOSERINE
O-ACETYLTRANSFERASE

(Bacillus
anthracis) 		PF00561
(Abhydrolase_1) 		3 GLU A  29
THR A  30
LEU A 136
 None
 0.70A 1v8bC-3i1iA:
4.3		 1v8bC-3i1iA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ita D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACC

(Escherichia
coli) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		3 GLU A 260
THR A 261
LEU A  27
 None
 0.68A 1v8bC-3itaA:
undetectable		 1v8bC-3itaA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kky SUPEROXIDE DISMUTASE
[MN]

(Deinococcus
radiodurans) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		3 GLU A  46
THR A  45
LEU A  70
 None
 0.52A 1v8bC-3kkyA:
undetectable		 1v8bC-3kkyA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ktd PREPHENATE
DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF02153
(PDH) 		3 GLU A 205
THR A 206
LEU A 255
 None
 0.70A 1v8bC-3ktdA:
3.9		 1v8bC-3ktdA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3led 3-OXOACYL-ACYL
CARRIER PROTEIN
SYNTHASE III

(Rhodopseudomonas
palustris) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		3 GLU A 184
THR A 330
LEU A  11
 None
 0.72A 1v8bC-3ledA:
undetectable		 1v8bC-3ledA:
21.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n58 ADENOSYLHOMOCYSTEINA
SE

(Brucella
abortus) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		3 GLU A 192
THR A 193
LEU A 378
 ADN  A 500 (-3.6A)
NAD  A 550 ( 3.0A)
NAD  A 550 (-4.3A)
 0.61A 1v8bC-3n58A:
57.8		 1v8bC-3n58A:
54.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3one ADENOSYLHOMOCYSTEINA
SE

(Lupinus luteus) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		3 GLU A 205
THR A 206
LEU A 395
 None
NAD  A 501 (-2.8A)
NAD  A 501 (-4.2A)
 0.38A 1v8bC-3oneA:
58.1		 1v8bC-3oneA:
57.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9s CARNITINYL-COA
DEHYDRATASE

(Mycobacterium
avium) 		PF00378
(ECH_1) 		3 GLU A 114
THR A 113
LEU A 161
 BEZ  A 264 (-2.6A)
None
None
 0.66A 1v8bC-3r9sA:
undetectable		 1v8bC-3r9sA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sgz HYDROXYACID OXIDASE
2

(Rattus
norvegicus) 		PF01070
(FMN_dh) 		3 GLU A  36
THR A  33
LEU A 226
 None
 0.69A 1v8bC-3sgzA:
undetectable		 1v8bC-3sgzA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vyg THIOCYANATE
HYDROLASE SUBUNIT
ALPHA

(Thiobacillus
thioparus) 		PF02211
(NHase_beta) 		3 GLU A 115
THR A 116
LEU A 101
 None
 0.72A 1v8bC-3vygA:
undetectable		 1v8bC-3vygA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wqu CELL DIVISION
PROTEIN FTSA

(Staphylococcus
aureus) 		PF02491
(SHS2_FTSA)
PF14450
(FtsA) 		3 GLU A  84
THR A  83
LEU A 222
 None
 0.66A 1v8bC-3wquA:
undetectable		 1v8bC-3wquA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zmr CELLULASE (GLYCOSYL
HYDROLASE FAMILY 5)

(Bacteroides
ovatus) 		PF00150
(Cellulase)
PF13004
(BACON) 		3 GLU A 182
THR A 166
LEU A 194
 None
 0.69A 1v8bC-3zmrA:
undetectable		 1v8bC-3zmrA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ae0 DIPHTHERIA TOXIN

(Corynebacterium
diphtheriae) 		PF01324
(Diphtheria_R)
PF02763
(Diphtheria_C)
PF02764
(Diphtheria_T) 		3 GLU A 168
THR A 169
LEU A 163
 None
 0.69A 1v8bC-4ae0A:
undetectable		 1v8bC-4ae0A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fys AMINOPEPTIDASE N

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		3 GLU A 742
THR A 737
LEU A 792
 None
 0.46A 1v8bC-4fysA:
undetectable		 1v8bC-4fysA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hqe TRANSCRIPTIONAL
REGULATOR QSRR

(Staphylococcus
aureus) 		PF01638
(HxlR) 		3 GLU A  10
THR A  11
LEU A  64
 None
 0.69A 1v8bC-4hqeA:
undetectable		 1v8bC-4hqeA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igl YENB

(Yersinia
entomophaga) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		3 GLU A1174
THR A1175
LEU A1197
 None
 0.70A 1v8bC-4iglA:
undetectable		 1v8bC-4iglA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ij3 HEAVY CHAIN OF FAB
FRAGMENT

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 GLU C 196
THR C 192
LEU C 164
 None
 0.71A 1v8bC-4ij3C:
undetectable		 1v8bC-4ij3C:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jlv C-TERMINAL FRAGMENT
OF MEMBRANE PROTEIN
CAPA1, PUTATIVE
UNCHARACTERIZED
PROTEIN CAPB1

(Staphylococcus
aureus) 		PF13614
(AAA_31) 		3 GLU A1109
THR A1105
LEU A1122
 None
 0.67A 1v8bC-4jlvA:
2.4		 1v8bC-4jlvA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kcd GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 3A

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		3 GLU A 155
THR A 154
LEU A 164
 None
 0.70A 1v8bC-4kcdA:
undetectable		 1v8bC-4kcdA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgl GLYCINE
DEHYDROGENASE
[DECARBOXYLATING]

(Synechocystis
sp. PCC 6803) 		PF02347
(GDC-P) 		3 GLU A 446
THR A 447
LEU A 295
 None
 0.72A 1v8bC-4lglA:
4.3		 1v8bC-4lglA:
19.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lvc S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE)

(Bradyrhizobium
elkanii) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		3 GLU A 197
THR A 198
LEU A 383
 ADN  A 501 (-3.6A)
NAD  A 503 ( 2.9A)
NAD  A 503 ( 3.9A)
 0.13A 1v8bC-4lvcA:
60.5		 1v8bC-4lvcA:
53.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mrp ABC TRANSPORTER
RELATED PROTEIN

(Novosphingobium
aromaticivorans) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		3 GLU A 490
THR A 489
LEU A 498
 None
 0.63A 1v8bC-4mrpA:
undetectable		 1v8bC-4mrpA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nof POLYMERIC
IMMUNOGLOBULIN
RECEPTOR

(Mus musculus) 		PF07686
(V-set) 		3 GLU A 181
THR A 180
LEU A 175
 None
 0.61A 1v8bC-4nofA:
undetectable		 1v8bC-4nofA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p3c HEAVY CHAIN FAB
FRAGMENT OF ANTIBODY
LEM-2/15

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 GLU H 196
THR H 192
LEU H 164
 None
 0.61A 1v8bC-4p3cH:
undetectable		 1v8bC-4p3cH:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0g PROBABLE
ACETYL-/PROPIONYL-CO
A CARBOXYLASE (BETA
SUBUNIT) ACCD1

(Mycobacterium
tuberculosis) 		PF01039
(Carboxyl_trans) 		3 GLU A  66
THR A  87
LEU A 492
 None
 0.61A 1v8bC-4q0gA:
2.4		 1v8bC-4q0gA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qt9 PUTATIVE
GLUCOAMYLASE

(Bacteroides
caccae) 		PF10091
(Glycoamylase) 		3 GLU A 285
THR A 284
LEU A 319
 None
 0.70A 1v8bC-4qt9A:
undetectable		 1v8bC-4qt9A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2x ENDO-BETA-1,4-GLUCAN
ASE (CELLULASE B)

(Bacillus
halodurans) 		PF00150
(Cellulase)
PF03442
(CBM_X2) 		3 GLU A  59
THR A  51
LEU A  71
 None
 0.59A 1v8bC-4v2xA:
2.4		 1v8bC-4v2xA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ww5 EKC/KEOPS COMPLEX
SUBUNIT CGI121

(Saccharomyces
cerevisiae) 		PF08617
(CGI-121) 		3 GLU B  77
THR B  60
LEU B 107
 None
 0.70A 1v8bC-4ww5B:
undetectable		 1v8bC-4ww5B:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wyq RISC-LOADING COMPLEX
SUBUNIT TARBP2

(Homo sapiens) 		PF16482
(Staufen_C) 		3 GLU B 328
THR B 335
LEU B 298
 None
 0.71A 1v8bC-4wyqB:
undetectable		 1v8bC-4wyqB:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x81 MYCINAMICIN III
3''-O-METHYLTRANSFER
ASE

(Micromonospora
griseorubida) 		PF05711
(TylF) 		3 GLU A  83
THR A  84
LEU A 183
 SAH  A 301 (-3.0A)
None
None
 0.60A 1v8bC-4x81A:
4.1		 1v8bC-4x81A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9n L-ALPHA-GLYCEROPHOSP
HATE OXIDASE

(Mycoplasma
pneumoniae) 		PF01266
(DAO) 		3 GLU A  21
THR A  18
LEU A 365
 None
 0.70A 1v8bC-4x9nA:
2.9		 1v8bC-4x9nA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpx ATP-DEPENDENT
PROTEASE LON

(Thermococcus
onnurineus) 		PF01078
(Mg_chelatase)
PF13654
(AAA_32) 		3 GLU A 284
THR A 283
LEU A 185
 None
 0.66A 1v8bC-4zpxA:
undetectable		 1v8bC-4zpxA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zrs ESTERASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		3 GLU A 273
THR A 272
LEU A   5
 None
 0.57A 1v8bC-4zrsA:
5.1		 1v8bC-4zrsA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zv7 LIPASE B

(Moesziomyces
antarcticus) 		no annotation 3 GLU A  81
THR A  80
LEU A 163
 None
 0.66A 1v8bC-4zv7A:
undetectable		 1v8bC-4zv7A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 GLU A 384
THR A 383
LEU A 405
 None
 0.70A 1v8bC-5ahkA:
undetectable		 1v8bC-5ahkA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5r GASDERMIN-A3

(Mus musculus) 		PF04598
(Gasdermin) 		3 GLU A 354
THR A 353
LEU A 181
 None
 0.57A 1v8bC-5b5rA:
undetectable		 1v8bC-5b5rA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ccx TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
NON-CATALYTIC
SUBUNIT TRM6

(Homo sapiens) 		PF04189
(Gcd10p) 		3 GLU B 207
THR B 208
LEU B 383
 None
 0.58A 1v8bC-5ccxB:
4.6		 1v8bC-5ccxB:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e0c CELLULASE

(Bacillus sp.
BG-CS10) 		PF00150
(Cellulase)
PF03442
(CBM_X2) 		3 GLU A  34
THR A  26
LEU A  46
 None
 0.61A 1v8bC-5e0cA:
undetectable		 1v8bC-5e0cA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i10 PROBABLE
O-METHYLTRANSFERASE

(Saccharopolyspora
spinosa) 		PF05711
(TylF) 		3 GLU A  81
THR A  82
LEU A 179
 None
 0.67A 1v8bC-5i10A:
2.0		 1v8bC-5i10A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j7r PUTATIVE LIPOPROTEIN

(Clostridium
perfringens) 		PF10646
(Germane) 		3 GLU A 120
THR A 101
LEU A 162
 None
 0.67A 1v8bC-5j7rA:
undetectable		 1v8bC-5j7rA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jm7 AEROBACTIN SYNTHASE
IUCA

(Klebsiella
pneumoniae) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		3 GLU A 504
THR A 493
LEU A 569
 None
 0.72A 1v8bC-5jm7A:
undetectable		 1v8bC-5jm7A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8g ANTIFREEZE PROTEIN

(Marinomonas
primoryensis) 		no annotation 3 GLU A 409
THR A 408
LEU A 500
 None
CA  A 616 (-3.7A)
None
 0.58A 1v8bC-5k8gA:
undetectable		 1v8bC-5k8gA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l75 FIG000988: PREDICTED
PERMEASE

(Klebsiella
pneumoniae) 		PF03739
(YjgP_YjgQ) 		3 GLU F  10
THR F  75
LEU F 105
 None
 0.68A 1v8bC-5l75F:
undetectable		 1v8bC-5l75F:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5naq BETA-GALACTOSIDASE

(Lactobacillus
plantarum) 		PF00232
(Glyco_hydro_1) 		3 GLU A  20
THR A  19
LEU A  73
 None
 0.51A 1v8bC-5naqA:
undetectable		 1v8bC-5naqA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ovo ADP-RIBOSYL-(DINITRO
GEN REDUCTASE)
HYDROLASE

(Azospirillum
brasilense) 		no annotation 3 GLU A  63
THR A  62
LEU A 272
 None
 0.65A 1v8bC-5ovoA:
undetectable		 1v8bC-5ovoA:
19.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5utu ADENOSYLHOMOCYSTEINA
SE

(Cryptosporidium
parvum) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		3 GLU A 211
THR A 212
LEU A 401
 SAH  A 502 (-3.8A)
NAD  A 501 ( 4.1A)
NAD  A 501 (-4.1A)
 0.50A 1v8bC-5utuA:
56.1		 1v8bC-5utuA:
52.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE

(Naegleria
fowleri) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		3 GLU A 197
THR A 198
LEU A 386
 ADN  A 502 (-3.5A)
NAD  A 501 ( 2.9A)
NAD  A 501 (-3.9A)
 0.18A 1v8bC-5v96A:
61.0		 1v8bC-5v96A:
55.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vae ACCESSORY SEC SYSTEM
PROTEIN ASP1

(Streptococcus
gordonii) 		no annotation 3 GLU A  73
THR A  72
LEU A  53
 None
 0.62A 1v8bC-5vaeA:
4.6		 1v8bC-5vaeA:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vl1 LYSINE--TRNA LIGASE

(Mycobacterium
ulcerans) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		3 GLU A 271
THR A 468
LEU A 190
 LYS  A 502 (-3.3A)
None
None
 0.67A 1v8bC-5vl1A:
undetectable		 1v8bC-5vl1A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4a P-GRANULE SCAFFOLD

(Caenorhabditis
japonica) 		no annotation 3 GLU A 159
THR A 147
LEU A 181
 None
 0.67A 1v8bC-5w4aA:
undetectable		 1v8bC-5w4aA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yww NUCLEOTIDE BINDING
PROTEIN PINC

(Sulfolobus
islandicus) 		no annotation 3 GLU A 134
THR A 135
LEU A 161
 None
 0.61A 1v8bC-5ywwA:
undetectable		 1v8bC-5ywwA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z9y THIAZOLE SYNTHASE

(Mycobacterium
tuberculosis) 		no annotation 3 GLU A  40
THR A  39
LEU A  61
 None
 0.71A 1v8bC-5z9yA:
2.8		 1v8bC-5z9yA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aqh LYSINE--TRNA LIGASE

(Mycolicibacterium
thermoresistibile) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		3 GLU A 274
THR A 472
LEU A 193
 LYS  A 601 (-3.5A)
None
None
 0.61A 1v8bC-6aqhA:
undetectable		 1v8bC-6aqhA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bm7 INACTIVE
S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROZYME

(Trypanosoma
brucei) 		no annotation 3 GLU E 249
THR E 250
LEU E 266
 None
 0.70A 1v8bC-6bm7E:
undetectable		 1v8bC-6bm7E:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bzy 22D11 HEAVY CHAIN

(Mus musculus) 		no annotation 3 GLU H 192
THR H 188
LEU H 159
 None
 0.61A 1v8bC-6bzyH:
undetectable		 1v8bC-6bzyH:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6etz BETA-GALACTOSIDASE

(Arthrobacter
sp. 32cB) 		no annotation 3 GLU A 393
THR A 394
LEU A 448
 None
 0.71A 1v8bC-6etzA:
undetectable		 1v8bC-6etzA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3m -

(-) 		no annotation 3 GLU B 164
THR B 165
LEU B 373
 ADN  B 502 (-3.6A)
NAD  B 501 ( 2.8A)
NAD  B 501 ( 3.9A)
 0.22A 1v8bC-6f3mB:
50.6		 1v8bC-6f3mB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fkh ATP SYNTHASE SUBUNIT
ALPHA, CHLOROPLASTIC

(Spinacia
oleracea) 		no annotation 3 GLU C 321
THR C 322
LEU C 167
 None
 0.72A 1v8bC-6fkhC:
undetectable		 1v8bC-6fkhC:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gbn -

(-) 		no annotation 3 GLU A 159
THR A 160
LEU A 347
 ADN  A 501 (-3.9A)
NAD  A 502 ( 2.8A)
NAD  A 502 (-3.9A)
 0.21A 1v8bC-6gbnA:
27.0		 1v8bC-6gbnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gqd GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE

(Homo sapiens) 		no annotation 3 GLU A 159
THR A 158
LEU A 318
 None
 0.72A 1v8bC-6gqdA:
undetectable		 1v8bC-6gqdA:
undetectable