SIMILAR PATTERNS OF AMINO ACIDS FOR 1V8B_B_ADNB1502_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0p SITE-SPECIFIC
RECOMBINASE XERD

(Escherichia
coli) 		PF00589
(Phage_integrase)
PF02899
(Phage_int_SAM_1) 		3 GLU A 184
GLU A 190
LEU A 133
 None
 0.47A 1v8bB-1a0pA:
undetectable		 1v8bB-1a0pA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bw0 PROTEIN (TYROSINE
AMINOTRANSFERASE)

(Trypanosoma
cruzi) 		PF00155
(Aminotran_1_2) 		3 GLU A 240
GLU A 200
LEU A 213
 None
 0.67A 1v8bB-1bw0A:
2.7		 1v8bB-1bw0A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ct5 PROTEIN (YEAST
HYPOTHETICAL
PROTEIN, SELENOMET)

(Saccharomyces
cerevisiae) 		PF01168
(Ala_racemase_N) 		3 GLU A  77
GLU A  69
LEU A 102
 None
 0.77A 1v8bB-1ct5A:
undetectable		 1v8bB-1ct5A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cte CATHEPSIN B

(Rattus
norvegicus) 		PF00112
(Peptidase_C1) 		3 GLU A 243
GLU A 159
LEU A   1
 None
 0.72A 1v8bB-1cteA:
undetectable		 1v8bB-1cteA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e32 P97

(Mus musculus) 		PF00004
(AAA)
PF02359
(CDC48_N)
PF02933
(CDC48_2) 		3 GLU A 195
GLU A 200
LEU A 153
 None
 0.75A 1v8bB-1e32A:
undetectable		 1v8bB-1e32A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ehy PROTEIN (SOLUBLE
EPOXIDE HYDROLASE)

(Agrobacterium
tumefaciens) 		PF00561
(Abhydrolase_1) 		3 GLU A  70
GLU A  13
LEU A  92
 None
 0.71A 1v8bB-1ehyA:
undetectable		 1v8bB-1ehyA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fdr FLAVODOXIN REDUCTASE

(Escherichia
coli) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		3 GLU A 190
GLU A 195
LEU A 181
 None
 0.71A 1v8bB-1fdrA:
3.0		 1v8bB-1fdrA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fyc DIHYDROLIPOAMIDE
ACETYLTRANSFERASE
(E2P)

(Homo sapiens) 		PF00364
(Biotin_lipoyl) 		3 GLU A  39
GLU A  86
LEU A  42
 None
 0.67A 1v8bB-1fycA:
undetectable		 1v8bB-1fycA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hix ENDO-1,4-BETA-XYLANA
SE

(Streptomyces
sp. S38) 		PF00457
(Glyco_hydro_11) 		3 GLU A 128
GLU A  87
LEU A 165
 None
 0.73A 1v8bB-1hixA:
undetectable		 1v8bB-1hixA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ik6 PYRUVATE
DEHYDROGENASE

(Pyrobaculum
aerophilum) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		3 GLU A 273
GLU A 138
LEU A 147
 None
 0.78A 1v8bB-1ik6A:
undetectable		 1v8bB-1ik6A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iqr PHOTOLYASE

(Thermus
thermophilus) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		3 GLU A 164
GLU A  72
LEU A  32
 None
 0.75A 1v8bB-1iqrA:
undetectable		 1v8bB-1iqrA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iuh 2'-5' RNA LIGASE

(Thermus
thermophilus) 		PF02834
(LigT_PEase) 		3 GLU A  12
GLU A  19
LEU A  38
 None
 0.60A 1v8bB-1iuhA:
undetectable		 1v8bB-1iuhA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jof CARBOXY-CIS,CIS-MUCO
NATE CYCLASE

(Neurospora
crassa) 		PF10282
(Lactonase) 		3 GLU A 296
GLU A 219
LEU A 262
 None
 0.61A 1v8bB-1jofA:
undetectable		 1v8bB-1jofA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jpd L-ALA-D/L-GLU
EPIMERASE

(Escherichia
coli) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 GLU X 214
GLU X 242
LEU X 234
 None
 0.78A 1v8bB-1jpdX:
3.3		 1v8bB-1jpdX:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k7y METHIONINE SYNTHASE

(Escherichia
coli) 		PF02310
(B12-binding)
PF02607
(B12-binding_2)
PF02965
(Met_synt_B12) 		3 GLU A 673
GLU A 676
LEU A 663
 None
 0.63A 1v8bB-1k7yA:
6.0		 1v8bB-1k7yA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kq3 GLYCEROL
DEHYDROGENASE

(Thermotoga
maritima) 		PF00465
(Fe-ADH) 		3 GLU A 332
GLU A 325
LEU A 261
 None
 0.72A 1v8bB-1kq3A:
2.5		 1v8bB-1kq3A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ksi COPPER AMINE OXIDASE

(Pisum sativum) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		3 GLU A 303
GLU A 107
LEU A 156
 None
 0.65A 1v8bB-1ksiA:
undetectable		 1v8bB-1ksiA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lt8 BETAINE-HOMOCYSTEINE
METHYLTRANSFERASE

(Homo sapiens) 		PF02574
(S-methyl_trans) 		3 GLU A 166
GLU A 172
LEU A 145
 None
 0.77A 1v8bB-1lt8A:
undetectable		 1v8bB-1lt8A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ma1 SUPEROXIDE DISMUTASE

(Methanothermobacter
thermautotrophicus) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		3 GLU A  96
GLU A 197
LEU A 143
 None
 0.76A 1v8bB-1ma1A:
undetectable		 1v8bB-1ma1A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o12 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE

(Thermotoga
maritima) 		PF01979
(Amidohydro_1) 		3 GLU A 155
GLU A 160
LEU A 172
 None
 0.64A 1v8bB-1o12A:
undetectable		 1v8bB-1o12A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ptj NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1

(Rhodospirillum
rubrum) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		3 GLU A  13
GLU A  86
LEU A 100
 None
 0.73A 1v8bB-1ptjA:
8.3		 1v8bB-1ptjA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1puz CONSERVED
HYPOTHETICAL PROTEIN

(Neisseria
meningitidis) 		PF03937
(Sdh5) 		3 GLU A  77
GLU A  34
LEU A  57
 None
 0.76A 1v8bB-1puzA:
undetectable		 1v8bB-1puzA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhx PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)

(Streptomyces
venezuelae) 		PF07931
(CPT) 		3 GLU A 153
GLU A 157
LEU A 115
 None
 0.69A 1v8bB-1qhxA:
undetectable		 1v8bB-1qhxA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r3n BETA-ALANINE
SYNTHASE

(Lachancea
kluyveri) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		3 GLU A 425
GLU A 431
LEU A 225
 None
 0.56A 1v8bB-1r3nA:
undetectable		 1v8bB-1r3nA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s5j DNA POLYMERASE I

(Sulfolobus
solfataricus) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		3 GLU A 550
GLU A 543
LEU A 632
 None
 0.78A 1v8bB-1s5jA:
undetectable		 1v8bB-1s5jA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s7u H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, D-B ALPHA
CHAIN

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		3 GLU A 128
GLU A 161
LEU A 103
 None
 0.62A 1v8bB-1s7uA:
undetectable		 1v8bB-1s7uA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sg9 HEMK PROTEIN

(Thermotoga
maritima) 		PF05175
(MTS) 		3 GLU A  97
GLU A 217
LEU A 207
 None
 0.72A 1v8bB-1sg9A:
2.6		 1v8bB-1sg9A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1taq TAQ DNA POLYMERASE

(Thermus
aquaticus) 		PF00476
(DNA_pol_A)
PF01367
(5_3_exonuc)
PF02739
(5_3_exonuc_N)
PF09281
(Taq-exonuc) 		3 GLU A 401
GLU A 397
LEU A 351
 None
 0.71A 1v8bB-1taqA:
3.3		 1v8bB-1taqA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tkc TRANSKETOLASE

(Saccharomyces
cerevisiae) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		3 GLU A 565
GLU A 506
LEU A 526
 None
 0.75A 1v8bB-1tkcA:
undetectable		 1v8bB-1tkcA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqh CARBOXYLESTERASE
PRECURSOR

(Geobacillus
stearothermophilus) 		PF12146
(Hydrolase_4) 		3 GLU A 146
GLU A 154
LEU A 132
 None
 0.74A 1v8bB-1tqhA:
6.2		 1v8bB-1tqhA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uc8 LYSINE BIOSYNTHESIS
ENZYME

(Thermus
thermophilus) 		PF08443
(RimK) 		3 GLU A 120
GLU A 114
LEU A 128
 None
 0.76A 1v8bB-1uc8A:
undetectable		 1v8bB-1uc8A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uli BIPHENYL DIOXYGENASE
LARGE SUBUNIT

(Rhodococcus
jostii) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		3 GLU A 157
GLU A  62
LEU A  58
 None
 0.78A 1v8bB-1uliA:
undetectable		 1v8bB-1uliA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1un9 DIHYDROXYACETONE
KINASE

(Citrobacter
freundii) 		PF02733
(Dak1)
PF02734
(Dak2) 		3 GLU A 222
GLU A 214
LEU A 189
 None
 0.75A 1v8bB-1un9A:
3.3		 1v8bB-1un9A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1unn DNA POLYMERASE IV

(Escherichia
coli) 		PF11799
(IMS_C) 		3 GLU C 264
GLU C 269
LEU C 307
 None
SO4  C1352 ( 4.0A)
None
 0.78A 1v8bB-1unnC:
undetectable		 1v8bB-1unnC:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uxt GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(NADP+)

(Thermoproteus
tenax) 		PF00171
(Aldedh) 		3 GLU A 473
GLU A 480
LEU A 158
 None
 0.74A 1v8bB-1uxtA:
4.9		 1v8bB-1uxtA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uyp BETA-FRUCTOSIDASE

(Thermotoga
maritima) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		3 GLU A 426
GLU A 325
LEU A 413
 None
 0.75A 1v8bB-1uypA:
undetectable		 1v8bB-1uypA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v27 REGULATING SYNAPTIC
MEMBRANE EXOCYTOSIS
PROTEIN 2

(Homo sapiens) 		PF00168
(C2) 		3 GLU A  89
GLU A 116
LEU A  23
 None
 0.62A 1v8bB-1v27A:
undetectable		 1v8bB-1v27A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4u HEMOGLOBIN BETA
CHAIN

(Thunnus thynnus) 		PF00042
(Globin) 		3 GLU B  83
GLU B  87
LEU B 141
 None
None
HEM  B 147 (-4.9A)
 0.74A 1v8bB-1v4uB:
undetectable		 1v8bB-1v4uB:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5x PHOSPHORIBOSYLANTHRA
NILATE ISOMERASE

(Thermus
thermophilus) 		PF00697
(PRAI) 		3 GLU A 158
GLU A 161
LEU A 171
 None
 0.67A 1v8bB-1v5xA:
undetectable		 1v8bB-1v5xA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcl HEMOLYTIC LECTIN
CEL-III

(Cucumaria
echinata) 		PF00652
(Ricin_B_lectin) 		3 GLU A 325
GLU A 152
LEU A 158
 None
 0.70A 1v8bB-1vclA:
undetectable		 1v8bB-1vclA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vyh PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
BETA SUBUNIT

(Homo sapiens) 		PF13472
(Lipase_GDSL_2) 		3 GLU A 112
GLU A 119
LEU A 139
 None
 0.76A 1v8bB-1vyhA:
2.5		 1v8bB-1vyhA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vyh PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
BETA SUBUNIT

(Homo sapiens) 		PF13472
(Lipase_GDSL_2) 		3 GLU A 113
GLU A 119
LEU A  82
 None
 0.78A 1v8bB-1vyhA:
2.5		 1v8bB-1vyhA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcx UROPORPHYRINOGEN III
SYNTHASE

(Thermus
thermophilus) 		PF02602
(HEM4) 		3 GLU A 170
GLU A 177
LEU A 198
 None
 0.53A 1v8bB-1wcxA:
6.5		 1v8bB-1wcxA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wlf PEROXISOME
BIOGENESIS FACTOR 1

(Mus musculus) 		PF09262
(PEX-1N)
PF09263
(PEX-2N) 		3 GLU A  62
GLU A  75
LEU A  94
 None
SO4  A 182 ( 4.8A)
None
 0.77A 1v8bB-1wlfA:
undetectable		 1v8bB-1wlfA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1woy METHIONYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1)
PF09334
(tRNA-synt_1g) 		3 GLU A 339
GLU A 327
LEU A  20
 None
 0.78A 1v8bB-1woyA:
2.1		 1v8bB-1woyA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wql ETHYLBENZENE
DIOXYGENASE SMALL
SUBUNIT

(Pseudomonas
fluorescens) 		PF00866
(Ring_hydroxyl_B) 		3 GLU B  20
GLU B  26
LEU B 154
 None
 0.72A 1v8bB-1wqlB:
undetectable		 1v8bB-1wqlB:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wuf HYPOTHETICAL PROTEIN
LIN2664

(Listeria
innocua) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 GLU A1240
GLU A1098
LEU A1262
 MG  A5001 (-3.1A)
None
None
 0.76A 1v8bB-1wufA:
undetectable		 1v8bB-1wufA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy2 XAA-PRO DIPEPTIDASE

(Pyrococcus
horikoshii) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		3 GLU A  80
GLU A  86
LEU A  46
 None
 0.59A 1v8bB-1wy2A:
undetectable		 1v8bB-1wy2A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wye 2-KETO-3-DEOXYGLUCON
ATE KINASE

(Sulfurisphaera
tokodaii) 		PF00294
(PfkB) 		3 GLU A 249
GLU A  13
LEU A  22
 None
 0.54A 1v8bB-1wyeA:
4.9		 1v8bB-1wyeA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yni SUCCINYLARGININE
DIHYDROLASE

(Escherichia
coli) 		PF04996
(AstB) 		3 GLU A 200
GLU A 219
LEU A 165
 None
 0.75A 1v8bB-1yniA:
undetectable		 1v8bB-1yniA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yt3 RIBONUCLEASE D

(Escherichia
coli) 		PF00570
(HRDC)
PF01612
(DNA_pol_A_exo1) 		3 GLU A 241
GLU A 267
LEU A 233
 None
SO4  A 606 ( 4.8A)
None
 0.71A 1v8bB-1yt3A:
undetectable		 1v8bB-1yt3A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yvd RAS-RELATED PROTEIN
RAB-22A

(Mus musculus) 		PF00071
(Ras) 		3 GLU A 127
GLU A 146
LEU A  96
 None
 0.73A 1v8bB-1yvdA:
2.9		 1v8bB-1yvdA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzx GLUTATHIONE
S-TRANSFERASE KAPPA
1

(Homo sapiens) 		PF01323
(DSBA) 		3 GLU A 112
GLU A 115
LEU A 103
 None
 0.74A 1v8bB-1yzxA:
undetectable		 1v8bB-1yzxA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z2a RAS-RELATED PROTEIN
RAB-23

(Mus musculus) 		PF00071
(Ras) 		3 GLU A 160
GLU A 167
LEU A  60
 None
 0.68A 1v8bB-1z2aA:
2.3		 1v8bB-1z2aA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA

(Mycobacterium
tuberculosis) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		3 GLU A 491
GLU A 520
LEU A 437
 None
 0.72A 1v8bB-1zj9A:
undetectable		 1v8bB-1zj9A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zjr TRNA
(GUANOSINE-2'-O-)-ME
THYLTRANSFERASE

(Aquifex
aeolicus) 		PF00588
(SpoU_methylase)
PF12105
(SpoU_methylas_C) 		3 GLU A 173
GLU A 167
LEU A  26
 None
 0.76A 1v8bB-1zjrA:
2.7		 1v8bB-1zjrA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zvs MHC CLASS I ANTIGEN

(Macaca mulatta) 		PF00129
(MHC_I)
PF07654
(C1-set) 		3 GLU A 128
GLU A 161
LEU A 103
 None
 0.70A 1v8bB-1zvsA:
undetectable		 1v8bB-1zvsA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a0j PTS SYSTEM, NITROGEN
REGULATORY IIA
PROTEIN

(Neisseria
meningitidis) 		PF00359
(PTS_EIIA_2) 		3 GLU A  52
GLU A  46
LEU A 104
 None
 0.75A 1v8bB-2a0jA:
undetectable		 1v8bB-2a0jA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Thermus
thermophilus) 		PF01409
(tRNA-synt_2d)
PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		3 GLU B 582
GLU A 126
LEU A 161
 None
 0.72A 1v8bB-2amcB:
undetectable		 1v8bB-2amcB:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2arh HYPOTHETICAL PROTEIN
AQ_1966

(Aquifex
aeolicus) 		PF06557
(DUF1122) 		3 GLU A 103
GLU A  83
LEU A  42
 None
 0.67A 1v8bB-2arhA:
undetectable		 1v8bB-2arhA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b39 C3

(Bos taurus) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		3 GLU A 262
GLU A 855
LEU A 859
 None
 0.52A 1v8bB-2b39A:
undetectable		 1v8bB-2b39A:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bmj CENTAURIN GAMMA 1

(Homo sapiens) 		PF00071
(Ras) 		3 GLU A 146
GLU A 210
LEU A  86
 None
 0.78A 1v8bB-2bmjA:
4.5		 1v8bB-2bmjA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bw3 TRANSPOSASE

(Musca domestica) 		PF05699
(Dimer_Tnp_hAT)
PF10683
(DBD_Tnp_Hermes) 		3 GLU A 238
GLU A 171
LEU A 196
 None
 0.74A 1v8bB-2bw3A:
undetectable		 1v8bB-2bw3A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE

(Deinococcus
radiodurans) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48)
PF11941
(DUF3459) 		3 GLU A 443
GLU A 155
LEU A 207
 None
 0.75A 1v8bB-2bxyA:
undetectable		 1v8bB-2bxyA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bzl TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 14

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 GLU A1094
GLU A1135
LEU A1177
 None
 0.64A 1v8bB-2bzlA:
undetectable		 1v8bB-2bzlA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c21 TRYPANOTHIONE-DEPEND
ENT GLYOXALASE I

(Leishmania
major) 		PF00903
(Glyoxalase) 		3 GLU A 124
GLU A 120
LEU A  27
 None
NI  A1143 (-2.8A)
None
 0.77A 1v8bB-2c21A:
2.2		 1v8bB-2c21A:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2chr CHLOROMUCONATE
CYCLOISOMERASE

(Cupriavidus
necator) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 GLU A 337
GLU A 340
LEU A 309
 None
 0.75A 1v8bB-2chrA:
undetectable		 1v8bB-2chrA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cn1 CYTOSOLIC
5'-NUCLEOTIDASE III

(Homo sapiens) 		PF05822
(UMPH-1) 		3 GLU A 273
GLU A 276
LEU A 225
 None
 0.69A 1v8bB-2cn1A:
3.4		 1v8bB-2cn1A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cu0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pyrococcus
horikoshii) 		PF00478
(IMPDH)
PF00571
(CBS) 		3 GLU A  30
GLU A 449
LEU A  22
 None
 0.57A 1v8bB-2cu0A:
undetectable		 1v8bB-2cu0A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d93 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 6

(Homo sapiens) 		PF00027
(cNMP_binding) 		3 GLU A  45
GLU A  42
LEU A  65
 None
 0.78A 1v8bB-2d93A:
undetectable		 1v8bB-2d93A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dav MYOSIN-BINDING
PROTEIN C, SLOW-TYPE

(Homo sapiens) 		PF07679
(I-set) 		3 GLU A  64
GLU A  67
LEU A  36
 None
 0.74A 1v8bB-2davA:
undetectable		 1v8bB-2davA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dc4 165AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii) 		PF01928
(CYTH) 		3 GLU A  12
GLU A  19
LEU A 124
 None
 0.65A 1v8bB-2dc4A:
undetectable		 1v8bB-2dc4A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dej PROBABLE
GALACTOKINASE

(Pyrococcus
horikoshii) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		3 GLU A 139
GLU A 109
LEU A  78
 None
 0.78A 1v8bB-2dejA:
undetectable		 1v8bB-2dejA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dne DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE
COMPONENT OF
PYRUVATE
DEHYDROGENASE
COMPLEX

(Homo sapiens) 		PF00364
(Biotin_lipoyl) 		3 GLU A  68
GLU A  45
LEU A  12
 None
 0.68A 1v8bB-2dneA:
undetectable		 1v8bB-2dneA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dwc 433AA LONG
HYPOTHETICAL
PHOSPHORIBOSYLGLYCIN
AMIDE FORMYL
TRANSFERASE

(Pyrococcus
horikoshii) 		PF02222
(ATP-grasp) 		3 GLU A 122
GLU A 202
LEU A 148
 None
ADP  A 501 (-4.1A)
None
 0.70A 1v8bB-2dwcA:
3.9		 1v8bB-2dwcA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Methanocaldococcus
jannaschii) 		PF01368
(DHH)
PF02833
(DHHA2) 		3 GLU A 281
GLU A 273
LEU A 287
 None
 0.58A 1v8bB-2eb0A:
2.9		 1v8bB-2eb0A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9z CHEMOTAXIS PROTEIN
CHEC

(Thermotoga
maritima) 		PF04509
(CheC) 		3 GLU A 112
GLU A 104
LEU A  88
 None
 0.58A 1v8bB-2f9zA:
undetectable		 1v8bB-2f9zA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fbn 70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE

(Plasmodium
falciparum) 		PF00515
(TPR_1)
PF13181
(TPR_8) 		3 GLU A  56
GLU A  63
LEU A  94
 None
 0.63A 1v8bB-2fbnA:
undetectable		 1v8bB-2fbnA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fep CATABOLITE CONTROL
PROTEIN A

(Bacillus
subtilis) 		PF13377
(Peripla_BP_3) 		3 GLU A 190
GLU A 151
LEU A 145
 None
 0.73A 1v8bB-2fepA:
5.9		 1v8bB-2fepA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fg5 RAS-RELATED PROTEIN
RAB-31

(Homo sapiens) 		PF00071
(Ras) 		3 GLU A 127
GLU A 146
LEU A  96
 None
 0.74A 1v8bB-2fg5A:
3.1		 1v8bB-2fg5A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g9d SUCCINYLGLUTAMATE
DESUCCINYLASE

(Vibrio cholerae) 		PF04952
(AstE_AspA) 		3 GLU A 191
GLU A 186
LEU A 216
 None
 0.71A 1v8bB-2g9dA:
undetectable		 1v8bB-2g9dA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2glj PROBABLE M18-FAMILY
AMINOPEPTIDASE 1

(Clostridium
acetobutylicum) 		PF02127
(Peptidase_M18) 		3 GLU A 128
GLU A 233
LEU A 202
 None
 0.77A 1v8bB-2gljA:
undetectable		 1v8bB-2gljA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h2q BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Trypanosoma
cruzi) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		3 GLU A  31
GLU A 228
LEU A 215
 None
 0.73A 1v8bB-2h2qA:
undetectable		 1v8bB-2h2qA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h4u THIOESTERASE
SUPERFAMILY MEMBER 2

(Homo sapiens) 		PF03061
(4HBT) 		3 GLU A  98
GLU A  45
LEU A  59
 None
 0.71A 1v8bB-2h4uA:
undetectable		 1v8bB-2h4uA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hls PROTEIN DISULFIDE
OXIDOREDUCTASE

(Aeropyrum
pernix) 		PF13192
(Thioredoxin_3) 		3 GLU A  40
GLU A 181
LEU A  48
 None
 0.70A 1v8bB-2hlsA:
undetectable		 1v8bB-2hlsA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hls PROTEIN DISULFIDE
OXIDOREDUCTASE

(Aeropyrum
pernix) 		PF13192
(Thioredoxin_3) 		3 GLU A 126
GLU A 122
LEU A 158
 None
 0.74A 1v8bB-2hlsA:
undetectable		 1v8bB-2hlsA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9u CYTOSINE/GUANINE
DEAMINASE RELATED
PROTEIN

(Clostridium
acetobutylicum) 		PF01979
(Amidohydro_1) 		3 GLU A 396
GLU A 402
LEU A 410
 None
 0.72A 1v8bB-2i9uA:
3.4		 1v8bB-2i9uA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT

(Thermus
thermophilus) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		3 GLU A 435
GLU A 441
LEU A 658
 None
 0.71A 1v8bB-2ipcA:
undetectable		 1v8bB-2ipcA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jf7 STRICTOSIDINE-O-BETA
-D-GLUCOSIDASE

(Rauvolfia
serpentina) 		PF00232
(Glyco_hydro_1) 		3 GLU A 331
GLU A 254
LEU A 305
 None
 0.65A 1v8bB-2jf7A:
undetectable		 1v8bB-2jf7A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfq GLUTAMATE RACEMASE

(Staphylococcus
aureus) 		PF01177
(Asp_Glu_race) 		3 GLU A  47
GLU A  55
LEU A  83
 None
 0.61A 1v8bB-2jfqA:
undetectable		 1v8bB-2jfqA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jj7 HEMOLYSIN II
REGULATORY PROTEIN

(Bacillus cereus) 		PF00440
(TetR_N) 		3 GLU A  26
GLU A  32
LEU A  54
 None
 0.78A 1v8bB-2jj7A:
undetectable		 1v8bB-2jj7A:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k5q HYPOTHETICAL
MEMBRANE ASSOCIATED
PROTEIN BCR97A

(Bacillus cereus) 		PF06486
(DUF1093) 		3 GLU A  21
GLU A  36
LEU A  59
 None
 0.76A 1v8bB-2k5qA:
undetectable		 1v8bB-2k5qA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2krh ACTIN-BINDING
RHO-ACTIVATING
PROTEIN

(Rattus
norvegicus) 		PF14705
(Costars) 		3 GLU A  13
GLU A  85
LEU A  55
 None
 0.76A 1v8bB-2krhA:
undetectable		 1v8bB-2krhA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ks6 UDP-N-ACETYLGLUCOSAM
INE TRANSFERASE
SUBUNIT ALG13

(Saccharomyces
cerevisiae) 		PF04101
(Glyco_tran_28_C) 		3 GLU A  66
GLU A  55
LEU A  86
 None
 0.62A 1v8bB-2ks6A:
4.7		 1v8bB-2ks6A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ktq PROTEIN (LARGE
FRAGMENT OF DNA
POLYMERASE I)

(Thermus
aquaticus) 		PF00476
(DNA_pol_A)
PF09281
(Taq-exonuc) 		3 GLU A 401
GLU A 397
LEU A 351
 None
 0.70A 1v8bB-2ktqA:
undetectable		 1v8bB-2ktqA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ld4 ANAMORSIN

(Homo sapiens) 		PF08241
(Methyltransf_11) 		3 GLU A 133
GLU A 129
LEU A  95
 None
 0.61A 1v8bB-2ld4A:
2.7		 1v8bB-2ld4A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lef PROTEIN (LYMPHOID
ENHANCER-BINDING
FACTOR)

(Mus musculus) 		PF00505
(HMG_box) 		3 GLU A  48
GLU A  54
LEU A  12
 None
 0.73A 1v8bB-2lefA:
undetectable		 1v8bB-2lefA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lm0 AF4/FMR2 FAMILY
MEMBER 1/PROTEIN
AF-9 CHIMERA

(Homo sapiens) 		PF05110
(AF-4) 		3 GLU A1509
GLU A1563
LEU A1517
 None
 0.77A 1v8bB-2lm0A:
undetectable		 1v8bB-2lm0A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m66 ENDOPLASMIC
RETICULUM RESIDENT
PROTEIN 29

(Rattus
norvegicus) 		PF07749
(ERp29) 		3 GLU A 170
GLU A 214
LEU A 181
 None
 0.74A 1v8bB-2m66A:
undetectable		 1v8bB-2m66A:
12.22