SIMILAR PATTERNS OF AMINO ACIDS FOR 1V8B_A_ADNA502_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0p SITE-SPECIFIC
RECOMBINASE XERD

(Escherichia
coli) 		PF00589
(Phage_integrase)
PF02899
(Phage_int_SAM_1) 		3 GLU A 184
GLU A 190
LEU A 133
 None
 0.51A 1v8bA-1a0pA:
undetectable		 1v8bA-1a0pA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cte CATHEPSIN B

(Rattus
norvegicus) 		PF00112
(Peptidase_C1) 		3 GLU A 243
GLU A 159
LEU A   1
 None
 0.70A 1v8bA-1cteA:
undetectable		 1v8bA-1cteA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e0k DNA HELICASE

(Escherichia
virus T7) 		PF03796
(DnaB_C) 		3 GLU A 538
GLU A 543
LEU A 356
 None
 0.75A 1v8bA-1e0kA:
undetectable		 1v8bA-1e0kA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e32 P97

(Mus musculus) 		PF00004
(AAA)
PF02359
(CDC48_N)
PF02933
(CDC48_2) 		3 GLU A 195
GLU A 200
LEU A 153
 None
 0.73A 1v8bA-1e32A:
undetectable		 1v8bA-1e32A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ehy PROTEIN (SOLUBLE
EPOXIDE HYDROLASE)

(Agrobacterium
tumefaciens) 		PF00561
(Abhydrolase_1) 		3 GLU A  70
GLU A  13
LEU A  92
 None
 0.72A 1v8bA-1ehyA:
undetectable		 1v8bA-1ehyA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fdr FLAVODOXIN REDUCTASE

(Escherichia
coli) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		3 GLU A 190
GLU A 195
LEU A 181
 None
 0.67A 1v8bA-1fdrA:
3.1		 1v8bA-1fdrA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fyc DIHYDROLIPOAMIDE
ACETYLTRANSFERASE
(E2P)

(Homo sapiens) 		PF00364
(Biotin_lipoyl) 		3 GLU A  39
GLU A  86
LEU A  42
 None
 0.72A 1v8bA-1fycA:
undetectable		 1v8bA-1fycA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hix ENDO-1,4-BETA-XYLANA
SE

(Streptomyces
sp. S38) 		PF00457
(Glyco_hydro_11) 		3 GLU A 128
GLU A  87
LEU A 165
 None
 0.72A 1v8bA-1hixA:
undetectable		 1v8bA-1hixA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iuh 2'-5' RNA LIGASE

(Thermus
thermophilus) 		PF02834
(LigT_PEase) 		3 GLU A  12
GLU A  19
LEU A  38
 None
 0.61A 1v8bA-1iuhA:
undetectable		 1v8bA-1iuhA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jof CARBOXY-CIS,CIS-MUCO
NATE CYCLASE

(Neurospora
crassa) 		PF10282
(Lactonase) 		3 GLU A 296
GLU A 219
LEU A 262
 None
 0.62A 1v8bA-1jofA:
undetectable		 1v8bA-1jofA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k7y METHIONINE SYNTHASE

(Escherichia
coli) 		PF02310
(B12-binding)
PF02607
(B12-binding_2)
PF02965
(Met_synt_B12) 		3 GLU A 673
GLU A 676
LEU A 663
 None
 0.63A 1v8bA-1k7yA:
2.0		 1v8bA-1k7yA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ksi COPPER AMINE OXIDASE

(Pisum sativum) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		3 GLU A 303
GLU A 107
LEU A 156
 None
 0.61A 1v8bA-1ksiA:
undetectable		 1v8bA-1ksiA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o12 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE

(Thermotoga
maritima) 		PF01979
(Amidohydro_1) 		3 GLU A 155
GLU A 160
LEU A 172
 None
 0.65A 1v8bA-1o12A:
undetectable		 1v8bA-1o12A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ptj NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1

(Rhodospirillum
rubrum) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		3 GLU A  13
GLU A  86
LEU A 100
 None
 0.71A 1v8bA-1ptjA:
8.4		 1v8bA-1ptjA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r3n BETA-ALANINE
SYNTHASE

(Lachancea
kluyveri) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		3 GLU A 425
GLU A 431
LEU A 225
 None
 0.57A 1v8bA-1r3nA:
undetectable		 1v8bA-1r3nA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s7u H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, D-B ALPHA
CHAIN

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		3 GLU A 128
GLU A 161
LEU A 103
 None
 0.60A 1v8bA-1s7uA:
undetectable		 1v8bA-1s7uA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1taq TAQ DNA POLYMERASE

(Thermus
aquaticus) 		PF00476
(DNA_pol_A)
PF01367
(5_3_exonuc)
PF02739
(5_3_exonuc_N)
PF09281
(Taq-exonuc) 		3 GLU A 401
GLU A 397
LEU A 351
 None
 0.75A 1v8bA-1taqA:
3.3		 1v8bA-1taqA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqh CARBOXYLESTERASE
PRECURSOR

(Geobacillus
stearothermophilus) 		PF12146
(Hydrolase_4) 		3 GLU A 146
GLU A 154
LEU A 132
 None
 0.70A 1v8bA-1tqhA:
6.1		 1v8bA-1tqhA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uxt GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(NADP+)

(Thermoproteus
tenax) 		PF00171
(Aldedh) 		3 GLU A 473
GLU A 480
LEU A 158
 None
 0.73A 1v8bA-1uxtA:
5.1		 1v8bA-1uxtA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v27 REGULATING SYNAPTIC
MEMBRANE EXOCYTOSIS
PROTEIN 2

(Homo sapiens) 		PF00168
(C2) 		3 GLU A  89
GLU A 116
LEU A  23
 None
 0.68A 1v8bA-1v27A:
undetectable		 1v8bA-1v27A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcx UROPORPHYRINOGEN III
SYNTHASE

(Thermus
thermophilus) 		PF02602
(HEM4) 		3 GLU A 170
GLU A 177
LEU A 198
 None
 0.53A 1v8bA-1wcxA:
6.5		 1v8bA-1wcxA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wql ETHYLBENZENE
DIOXYGENASE SMALL
SUBUNIT

(Pseudomonas
fluorescens) 		PF00866
(Ring_hydroxyl_B) 		3 GLU B  20
GLU B  26
LEU B 154
 None
 0.73A 1v8bA-1wqlB:
undetectable		 1v8bA-1wqlB:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy2 XAA-PRO DIPEPTIDASE

(Pyrococcus
horikoshii) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		3 GLU A  80
GLU A  86
LEU A  46
 None
 0.58A 1v8bA-1wy2A:
undetectable		 1v8bA-1wy2A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wye 2-KETO-3-DEOXYGLUCON
ATE KINASE

(Sulfurisphaera
tokodaii) 		PF00294
(PfkB) 		3 GLU A 249
GLU A  13
LEU A  22
 None
 0.55A 1v8bA-1wyeA:
4.6		 1v8bA-1wyeA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yni SUCCINYLARGININE
DIHYDROLASE

(Escherichia
coli) 		PF04996
(AstB) 		3 GLU A 200
GLU A 219
LEU A 165
 None
 0.74A 1v8bA-1yniA:
undetectable		 1v8bA-1yniA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yt3 RIBONUCLEASE D

(Escherichia
coli) 		PF00570
(HRDC)
PF01612
(DNA_pol_A_exo1) 		3 GLU A 241
GLU A 267
LEU A 233
 None
SO4  A 606 ( 4.8A)
None
 0.66A 1v8bA-1yt3A:
undetectable		 1v8bA-1yt3A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yvd RAS-RELATED PROTEIN
RAB-22A

(Mus musculus) 		PF00071
(Ras) 		3 GLU A 127
GLU A 146
LEU A  96
 None
 0.73A 1v8bA-1yvdA:
2.9		 1v8bA-1yvdA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzx GLUTATHIONE
S-TRANSFERASE KAPPA
1

(Homo sapiens) 		PF01323
(DSBA) 		3 GLU A 112
GLU A 115
LEU A 103
 None
 0.73A 1v8bA-1yzxA:
undetectable		 1v8bA-1yzxA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z2a RAS-RELATED PROTEIN
RAB-23

(Mus musculus) 		PF00071
(Ras) 		3 GLU A 160
GLU A 167
LEU A  60
 None
 0.60A 1v8bA-1z2aA:
2.3		 1v8bA-1z2aA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zjr TRNA
(GUANOSINE-2'-O-)-ME
THYLTRANSFERASE

(Aquifex
aeolicus) 		PF00588
(SpoU_methylase)
PF12105
(SpoU_methylas_C) 		3 GLU A 173
GLU A 167
LEU A  26
 None
 0.72A 1v8bA-1zjrA:
2.7		 1v8bA-1zjrA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zvs MHC CLASS I ANTIGEN

(Macaca mulatta) 		PF00129
(MHC_I)
PF07654
(C1-set) 		3 GLU A 128
GLU A 161
LEU A 103
 None
 0.65A 1v8bA-1zvsA:
undetectable		 1v8bA-1zvsA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Thermus
thermophilus) 		PF01409
(tRNA-synt_2d)
PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		3 GLU B 582
GLU A 126
LEU A 161
 None
 0.74A 1v8bA-2amcB:
undetectable		 1v8bA-2amcB:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2arh HYPOTHETICAL PROTEIN
AQ_1966

(Aquifex
aeolicus) 		PF06557
(DUF1122) 		3 GLU A 103
GLU A  83
LEU A  42
 None
 0.64A 1v8bA-2arhA:
undetectable		 1v8bA-2arhA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b39 C3

(Bos taurus) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		3 GLU A 262
GLU A 855
LEU A 859
 None
 0.56A 1v8bA-2b39A:
undetectable		 1v8bA-2b39A:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cu0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pyrococcus
horikoshii) 		PF00478
(IMPDH)
PF00571
(CBS) 		3 GLU A  30
GLU A 449
LEU A  22
 None
 0.60A 1v8bA-2cu0A:
undetectable		 1v8bA-2cu0A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d93 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 6

(Homo sapiens) 		PF00027
(cNMP_binding) 		3 GLU A  45
GLU A  42
LEU A  65
 None
 0.70A 1v8bA-2d93A:
undetectable		 1v8bA-2d93A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dc4 165AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii) 		PF01928
(CYTH) 		3 GLU A  12
GLU A  19
LEU A 124
 None
 0.68A 1v8bA-2dc4A:
undetectable		 1v8bA-2dc4A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dne DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE
COMPONENT OF
PYRUVATE
DEHYDROGENASE
COMPLEX

(Homo sapiens) 		PF00364
(Biotin_lipoyl) 		3 GLU A  68
GLU A  45
LEU A  12
 None
 0.72A 1v8bA-2dneA:
undetectable		 1v8bA-2dneA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Methanocaldococcus
jannaschii) 		PF01368
(DHH)
PF02833
(DHHA2) 		3 GLU A 281
GLU A 273
LEU A 287
 None
 0.59A 1v8bA-2eb0A:
2.7		 1v8bA-2eb0A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9z CHEMOTAXIS PROTEIN
CHEC

(Thermotoga
maritima) 		PF04509
(CheC) 		3 GLU A 112
GLU A 104
LEU A  88
 None
 0.60A 1v8bA-2f9zA:
undetectable		 1v8bA-2f9zA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fbn 70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE

(Plasmodium
falciparum) 		PF00515
(TPR_1)
PF13181
(TPR_8) 		3 GLU A  56
GLU A  63
LEU A  94
 None
 0.60A 1v8bA-2fbnA:
undetectable		 1v8bA-2fbnA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g9d SUCCINYLGLUTAMATE
DESUCCINYLASE

(Vibrio cholerae) 		PF04952
(AstE_AspA) 		3 GLU A 191
GLU A 186
LEU A 216
 None
 0.68A 1v8bA-2g9dA:
undetectable		 1v8bA-2g9dA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h4u THIOESTERASE
SUPERFAMILY MEMBER 2

(Homo sapiens) 		PF03061
(4HBT) 		3 GLU A  98
GLU A  45
LEU A  59
 None
 0.65A 1v8bA-2h4uA:
undetectable		 1v8bA-2h4uA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hls PROTEIN DISULFIDE
OXIDOREDUCTASE

(Aeropyrum
pernix) 		PF13192
(Thioredoxin_3) 		3 GLU A  40
GLU A 181
LEU A  48
 None
 0.72A 1v8bA-2hlsA:
undetectable		 1v8bA-2hlsA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9u CYTOSINE/GUANINE
DEAMINASE RELATED
PROTEIN

(Clostridium
acetobutylicum) 		PF01979
(Amidohydro_1) 		3 GLU A 396
GLU A 402
LEU A 410
 None
 0.73A 1v8bA-2i9uA:
3.4		 1v8bA-2i9uA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfq GLUTAMATE RACEMASE

(Staphylococcus
aureus) 		PF01177
(Asp_Glu_race) 		3 GLU A  47
GLU A  55
LEU A  83
 None
 0.61A 1v8bA-2jfqA:
undetectable		 1v8bA-2jfqA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jj7 HEMOLYSIN II
REGULATORY PROTEIN

(Bacillus cereus) 		PF00440
(TetR_N) 		3 GLU A  26
GLU A  32
LEU A  54
 None
 0.74A 1v8bA-2jj7A:
undetectable		 1v8bA-2jj7A:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ks6 UDP-N-ACETYLGLUCOSAM
INE TRANSFERASE
SUBUNIT ALG13

(Saccharomyces
cerevisiae) 		PF04101
(Glyco_tran_28_C) 		3 GLU A  66
GLU A  55
LEU A  86
 None
 0.62A 1v8bA-2ks6A:
4.7		 1v8bA-2ks6A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ld4 ANAMORSIN

(Homo sapiens) 		PF08241
(Methyltransf_11) 		3 GLU A 133
GLU A 129
LEU A  95
 None
 0.61A 1v8bA-2ld4A:
2.8		 1v8bA-2ld4A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lm0 AF4/FMR2 FAMILY
MEMBER 1/PROTEIN
AF-9 CHIMERA

(Homo sapiens) 		PF05110
(AF-4) 		3 GLU A1509
GLU A1563
LEU A1517
 None
 0.72A 1v8bA-2lm0A:
undetectable		 1v8bA-2lm0A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nnj CYTOCHROME P450 2C8

(Homo sapiens) 		PF00067
(p450) 		3 GLU A  85
GLU A  93
LEU A 380
 None
 0.68A 1v8bA-2nnjA:
undetectable		 1v8bA-2nnjA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nsa TRIGGER FACTOR

(Thermotoga
maritima) 		PF05698
(Trigger_C) 		3 GLU A 266
GLU A 273
LEU A 255
 None
 0.75A 1v8bA-2nsaA:
undetectable		 1v8bA-2nsaA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nxx ECDYSONE RECEPTOR
(ECR, NRH1)
ULTRASPIRACLE (USP,
NR2B4)

(Tribolium
castaneum) 		PF00104
(Hormone_recep) 		3 GLU A 298
GLU E 478
LEU E 390
 None
 0.67A 1v8bA-2nxxA:
undetectable		 1v8bA-2nxxA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5v DNA REPLICATION AND
REPAIR PROTEIN RECF

(Deinococcus
radiodurans) 		PF02463
(SMC_N) 		3 GLU A 148
GLU A 154
LEU A 179
 None
 0.74A 1v8bA-2o5vA:
undetectable		 1v8bA-2o5vA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2opj O-SUCCINYLBENZOATE-C
OA SYNTHASE

(Thermobifida
fusca) 		PF13378
(MR_MLE_C) 		3 GLU A  23
GLU A  35
LEU A 303
 None
 0.60A 1v8bA-2opjA:
3.2		 1v8bA-2opjA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2osa N-CHIMAERIN

(Homo sapiens) 		PF00620
(RhoGAP) 		3 GLU A 334
GLU A 291
LEU A 302
 None
 0.73A 1v8bA-2osaA:
undetectable		 1v8bA-2osaA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0o HYPOTHETICAL PROTEIN
DUF871

(Enterococcus
faecalis) 		PF05913
(DUF871) 		3 GLU A 159
GLU A 166
LEU A 122
 None
 0.71A 1v8bA-2p0oA:
undetectable		 1v8bA-2p0oA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pk3 GDP-6-DEOXY-D-LYXO-4
-HEXULOSE REDUCTASE

(Aneurinibacillus
thermoaerophilus) 		PF16363
(GDP_Man_Dehyd) 		3 GLU A 130
GLU A 117
LEU A 276
 None
 0.71A 1v8bA-2pk3A:
5.3		 1v8bA-2pk3A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2puz IMIDAZOLONEPROPIONAS
E

(Agrobacterium
fabrum) 		PF01979
(Amidohydro_1) 		3 GLU A 230
GLU A 238
LEU A 268
 None
 0.72A 1v8bA-2puzA:
2.4		 1v8bA-2puzA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyg RIBULOSE
BISPHOSPHATE
CARBOXYLASE-LIKE
PROTEIN 2

(Rhodopseudomonas
palustris) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		3 GLU A 242
GLU A 248
LEU A 276
 None
 0.68A 1v8bA-2qygA:
undetectable		 1v8bA-2qygA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjb UNCHARACTERIZED
PROTEIN

(Shigella
flexneri) 		PF07063
(DUF1338) 		3 GLU A 139
GLU A 207
LEU A 131
 None
 0.74A 1v8bA-2rjbA:
undetectable		 1v8bA-2rjbA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vlt THIOREDOXIN H
ISOFORM 2.

(Hordeum vulgare) 		PF00085
(Thioredoxin) 		3 GLU A  21
GLU A  28
LEU A  69
 None
 0.75A 1v8bA-2vltA:
undetectable		 1v8bA-2vltA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbm RIBOSOME MATURATION
PROTEIN SDO1 HOMOLOG

(Methanothermobacter
thermautotrophicus) 		PF01172
(SBDS)
PF09377
(SBDS_C) 		3 GLU A  34
GLU A  30
LEU A  81
 None
 0.59A 1v8bA-2wbmA:
undetectable		 1v8bA-2wbmA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wte CSA3

(Sulfolobus
solfataricus) 		no annotation 3 GLU A  47
GLU A  12
LEU A  30
 None
 0.75A 1v8bA-2wteA:
undetectable		 1v8bA-2wteA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wu0 PHYTASE

(Klebsiella
pneumoniae) 		PF00328
(His_Phos_2) 		3 GLU A  70
GLU A  21
LEU A  16
 None
 0.75A 1v8bA-2wu0A:
undetectable		 1v8bA-2wu0A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wu0 PHYTASE

(Klebsiella
pneumoniae) 		PF00328
(His_Phos_2) 		3 GLU A  70
GLU A  21
LEU A  80
 None
 0.74A 1v8bA-2wu0A:
undetectable		 1v8bA-2wu0A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wyr COBALT-ACTIVATED
PEPTIDASE TET1

(Pyrococcus
horikoshii) 		PF05343
(Peptidase_M42) 		3 GLU A 137
GLU A 144
LEU A 105
 None
 0.55A 1v8bA-2wyrA:
undetectable		 1v8bA-2wyrA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0q ALCALIGIN
BIOSYNTHESIS PROTEIN

(Bordetella
bronchiseptica) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		3 GLU A 327
GLU A 380
LEU A 215
 None
 0.74A 1v8bA-2x0qA:
undetectable		 1v8bA-2x0qA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxm MYOSIN-BINDING
PROTEIN C, SLOW-TYPE

(Homo sapiens) 		PF07679
(I-set) 		3 GLU A  38
GLU A  47
LEU A  65
 None
 0.74A 1v8bA-2yxmA:
undetectable		 1v8bA-2yxmA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aoe GLUTAMATE
DEHYDROGENASE

(Thermus
thermophilus) 		no annotation 3 GLU E 368
GLU E 375
LEU E 354
 None
 0.72A 1v8bA-3aoeE:
2.5		 1v8bA-3aoeE:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3azq AMINOPEPTIDASE

(Streptomyces
morookaense) 		PF00326
(Peptidase_S9) 		3 GLU A 631
GLU A 638
LEU A 588
 None
 0.55A 1v8bA-3azqA:
3.2		 1v8bA-3azqA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b96 VERY LONG-CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 GLU A  57
GLU A  64
LEU A 115
 None
 0.70A 1v8bA-3b96A:
undetectable		 1v8bA-3b96A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bu8 TELOMERIC
REPEAT-BINDING
FACTOR 2

(Homo sapiens) 		PF08558
(TRF) 		3 GLU A 114
GLU A 170
LEU A 204
 None
 0.65A 1v8bA-3bu8A:
undetectable		 1v8bA-3bu8A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0u UNCHARACTERIZED
PROTEIN YAEQ

(Escherichia
coli) 		PF07152
(YaeQ) 		3 GLU A  66
GLU A  68
LEU A  55
 None
 0.73A 1v8bA-3c0uA:
undetectable		 1v8bA-3c0uA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmg PUTATIVE
BETA-GALACTOSIDASE

(Bacteroides
fragilis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		3 GLU A 410
GLU A 451
LEU A 426
 None
MPD  A 800 ( 4.3A)
None
 0.62A 1v8bA-3cmgA:
undetectable		 1v8bA-3cmgA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ct4 PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK

(Lactococcus
lactis) 		PF02733
(Dak1) 		3 GLU A 246
GLU A 285
LEU A 308
 None
 0.72A 1v8bA-3ct4A:
undetectable		 1v8bA-3ct4A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cx6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-13
SUBUNIT

(Mus musculus) 		PF00503
(G-alpha) 		3 GLU A 229
GLU A 235
LEU A  52
 None
 0.73A 1v8bA-3cx6A:
undetectable		 1v8bA-3cx6A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cze SUCROSE HYDROLASE

(Xanthomonas
citri) 		PF00128
(Alpha-amylase) 		3 GLU A 167
GLU A 275
LEU A 158
 None
 0.62A 1v8bA-3czeA:
2.6		 1v8bA-3czeA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7j UNCHARACTERIZED
PROTEIN SCO6650

(Streptomyces
coelicolor) 		PF01242
(PTPS) 		3 GLU A  97
GLU A  58
LEU A 111
 None
 0.71A 1v8bA-3d7jA:
undetectable		 1v8bA-3d7jA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dsm UNCHARACTERIZED
PROTEIN BACUNI_02894

(Bacteroides
uniformis) 		no annotation 3 GLU A 225
GLU A 230
LEU A 182
 None
 0.69A 1v8bA-3dsmA:
undetectable		 1v8bA-3dsmA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egc PUTATIVE RIBOSE
OPERON REPRESSOR

(Burkholderia
thailandensis) 		PF00532
(Peripla_BP_1) 		3 GLU A 135
GLU A 112
LEU A 143
 None
 0.73A 1v8bA-3egcA:
5.5		 1v8bA-3egcA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ffy PUTATIVE
TETRAPYRROLE
(CORRIN/PORPHYRIN)
METHYLASE

(Bacteroides
fragilis) 		no annotation 3 GLU A 178
GLU A 201
LEU A 168
 None
 0.74A 1v8bA-3ffyA:
undetectable		 1v8bA-3ffyA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g77 CYTOSINE DEAMINASE

(Escherichia
coli) 		PF07969
(Amidohydro_3) 		3 GLU A  90
GLU A 157
LEU A  81
 None
 0.64A 1v8bA-3g77A:
2.3		 1v8bA-3g77A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gq9 PRENECK APPENDAGE
PROTEIN

(Bacillus virus
phi29) 		PF11962
(Peptidase_G2)
PF12708
(Pectate_lyase_3) 		3 GLU A 181
GLU A 125
LEU A 155
 None
 0.67A 1v8bA-3gq9A:
undetectable		 1v8bA-3gq9A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h84 ATPASE GET3

(Saccharomyces
cerevisiae) 		PF02374
(ArsA_ATPase) 		3 GLU A  68
GLU A  87
LEU A  52
 None
 0.73A 1v8bA-3h84A:
undetectable		 1v8bA-3h84A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hq0 CATECHOL
2,3-DIOXYGENASE

(Pseudomonas
alkylphenolica) 		PF00903
(Glyoxalase) 		3 GLU A 106
GLU A 119
LEU A  86
 None
 0.73A 1v8bA-3hq0A:
undetectable		 1v8bA-3hq0A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ioy SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Novosphingobium
aromaticivorans) 		PF00106
(adh_short) 		3 GLU A 274
GLU A 266
LEU A 155
 None
 0.57A 1v8bA-3ioyA:
6.6		 1v8bA-3ioyA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4s FTSZ/TUBULIN-RELATED
PROTEIN

(Bacillus
thuringiensis) 		PF00091
(Tubulin) 		3 GLU A 238
GLU A  37
LEU A  68
 None
 0.66A 1v8bA-3j4sA:
5.4		 1v8bA-3j4sA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kyo MHC CLASS I ANTIGEN

(Homo sapiens) 		PF00129
(MHC_I)
PF07654
(C1-set) 		3 GLU A 128
GLU A 161
LEU A 103
 None
 0.70A 1v8bA-3kyoA:
undetectable		 1v8bA-3kyoA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l44 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
1

(Bacillus
anthracis) 		PF00202
(Aminotran_3) 		3 GLU A 414
GLU A 421
LEU A 336
 None
 0.72A 1v8bA-3l44A:
2.0		 1v8bA-3l44A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6i UNCHARACTERIZED
LIPOPROTEIN YCEB

(Escherichia
coli) 		PF07273
(DUF1439) 		3 GLU A  60
GLU A  21
LEU A 105
 None
 0.57A 1v8bA-3l6iA:
undetectable		 1v8bA-3l6iA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldr FRUCTOSYLTRANSFERASE

(Aspergillus
japonicus) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		3 GLU A 302
GLU A 426
LEU A 463
 None
 0.62A 1v8bA-3ldrA:
undetectable		 1v8bA-3ldrA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lez BETA-LACTAMASE

(Oceanobacillus
iheyensis) 		PF13354
(Beta-lactamase2) 		3 GLU A 106
GLU A 134
LEU A 151
 None
 0.74A 1v8bA-3lezA:
undetectable		 1v8bA-3lezA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lsz GLUTATHIONE
S-TRANSFERASE

(Rhodobacter
sphaeroides) 		PF00043
(GST_C)
PF02798
(GST_N) 		3 GLU A  68
GLU A  27
LEU A  16
 None
 0.72A 1v8bA-3lszA:
undetectable		 1v8bA-3lszA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdu N-FORMIMINO-L-GLUTAM
ATE IMINOHYDROLASE

(Pseudomonas
aeruginosa) 		PF01979
(Amidohydro_1) 		3 GLU A  98
GLU A 118
LEU A 194
 GOL  A 457 (-3.5A)
None
None
 0.72A 1v8bA-3mduA:
undetectable		 1v8bA-3mduA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		3 GLU A  64
GLU A  44
LEU A  40
 None
 0.73A 1v8bA-3mvjA:
undetectable		 1v8bA-3mvjA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nap CAPSID PROTEIN

(Triatoma virus) 		PF00073
(Rhv) 		3 GLU C 249
GLU B 101
LEU B 149
 None
 0.68A 1v8bA-3napC:
undetectable		 1v8bA-3napC:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3obf PUTATIVE
TRANSCRIPTIONAL
REGULATOR, ICLR
FAMILY

(Paenarthrobacter
aurescens) 		PF01614
(IclR) 		3 GLU A 241
GLU A 183
LEU A 193
 None
 0.72A 1v8bA-3obfA:
undetectable		 1v8bA-3obfA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oc5 TOXIN COREGULATED
PILUS BIOSYNTHESIS
PROTEIN F

(Vibrio cholerae) 		PF06340
(TcpF) 		3 GLU A 144
GLU A 108
LEU A 164
 None
 0.71A 1v8bA-3oc5A:
undetectable		 1v8bA-3oc5A:
23.01