SIMILAR PATTERNS OF AMINO ACIDS FOR 1V7Z_D_CRND5401_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bqb PROTEIN (AUREOLYSIN)

(Staphylococcus
aureus) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		5 GLU A 168
HIS A 144
HIS A 228
HIS A 148
GLU A 145
 ZN  A 350 (-2.2A)
ZN  A 350 (-3.3A)
None
ZN  A 350 (-3.3A)
ZN  A 350 ( 4.6A)
 1.20A 1v7zD-1bqbA:
undetectable		 1v7zD-1bqbA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cg2 CARBOXYPEPTIDASE G2

(Pseudomonas sp.
RS-16) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 GLU A 200
HIS A 112
ASP A 141
GLU A 176
 ZN  A 501 ( 1.9A)
ZN  A 501 ( 3.3A)
ZN  A 500 (-2.4A)
ZN  A 500 ( 2.0A)
 0.84A 1v7zD-1cg2A:
4.9		 1v7zD-1cg2A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f4h BETA-GALACTOSIDASE

(Escherichia
coli) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 HIS A 972
ASP A 591
TYR A 100
TRP A 203
 None
 0.97A 1v7zD-1f4hA:
undetectable		 1v7zD-1f4hA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hi9 DIPEPTIDE TRANSPORT
PROTEIN DPPA

(Bacillus
subtilis) 		PF04951
(Peptidase_M55) 		6 GLU A  10
HIS A 104
ASP A   8
HIS A  60
HIS A 115
GLU A 133
 ZN  A 301 (-2.3A)
ZN  A 300 (-3.1A)
ZN  A 301 ( 2.5A)
ZN  A 301 (-3.6A)
ZN  A 300 (-4.4A)
ZN  A 300 (-2.1A)
 0.78A 1v7zD-1hi9A:
4.0		 1v7zD-1hi9A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hmd HEMERYTHRIN

(Themiste
dyscritum) 		no annotation 5 GLU A  58
ASP A 106
HIS A  73
TRP A  97
HIS A  54
 FEO  A 115 (-2.5A)
FEO  A 115 (-2.6A)
FEO  A 115 (-3.4A)
None
FEO  A 115 (-3.5A)
 1.29A 1v7zD-1hmdA:
undetectable		 1v7zD-1hmdA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m68 HYPOTHETICAL PROTEIN
YCDX

(Escherichia
coli) 		PF02811
(PHP) 		5 GLU A  73
HIS A   9
ASP A 192
HIS A 131
HIS A  40
 ZN  A 303 ( 2.3A)
ZN  A 302 (-3.3A)
ZN  A 302 (-2.6A)
ZN  A 303 (-3.4A)
ZN  A 301 (-3.2A)
 1.15A 1v7zD-1m68A:
undetectable		 1v7zD-1m68A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1npc NEUTRAL PROTEASE

(Bacillus cereus) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		5 GLU A 167
HIS A 143
HIS A 232
HIS A 147
GLU A 144
 ZN  A 323 ( 2.0A)
ZN  A 323 ( 3.3A)
None
ZN  A 323 ( 3.2A)
ZN  A 323 ( 4.5A)
 1.25A 1v7zD-1npcA:
undetectable		 1v7zD-1npcA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o12 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE

(Thermotoga
maritima) 		PF01979
(Amidohydro_1) 		4 GLU A 115
HIS A  51
ASP A 255
HIS A 197
 FE  A 401 (-2.6A)
None
None
FE  A 401 (-3.5A)
 0.91A 1v7zD-1o12A:
undetectable		 1v7zD-1o12A:
25.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q3k CREATININASE

(Pseudomonas
putida) 		PF02633
(Creatininase) 		8 GLU A  34
HIS A  36
ASP A  45
HIS A 120
TYR A 121
TRP A 154
HIS A 178
GLU A 183
 ZN  A 300 (-2.5A)
ZN  A 301 (-3.3A)
ZN  A 301 ( 2.3A)
ZN  A 300 (-3.5A)
None
None
ZN  A 300 ( 4.9A)
ZN  A 301 (-2.1A)
 0.16A 1v7zD-1q3kA:
43.4		 1v7zD-1q3kA:
96.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q7l AMINOACYLASE-1

(Homo sapiens) 		PF01546
(Peptidase_M20) 		4 GLU A 175
HIS A  80
ASP A 113
GLU A 148
 ZN  A1002 ( 1.9A)
ZN  A1002 ( 3.2A)
ZN  A1002 (-2.5A)
ZN  A1001 (-1.9A)
 0.88A 1v7zD-1q7lA:
undetectable		 1v7zD-1q7lA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urt CARBONIC ANHYDRASE V

(Mus musculus) 		PF00194
(Carb_anhydrase) 		4 HIS A 119
TYR A 245
HIS A  96
GLU A 117
 ZN  A 280 (-3.2A)
None
ZN  A 280 (-3.2A)
None
 0.97A 1v7zD-1urtA:
undetectable		 1v7zD-1urtA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xp3 ENDONUCLEASE IV

(Bacillus
anthracis) 		PF01261
(AP_endonuc_2) 		4 GLU A 260
HIS A 230
ASP A 180
HIS A 215
 ZN  A 303 ( 2.6A)
SO4  A 304 (-3.3A)
ZN  A 303 ( 3.3A)
ZN  A 303 (-3.5A)
 0.98A 1v7zD-1xp3A:
undetectable		 1v7zD-1xp3A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y79 PEPTIDYL-DIPEPTIDASE
DCP

(Escherichia
coli) 		PF01432
(Peptidase_M3) 		4 GLU 1 498
HIS 1 469
HIS 1 473
GLU 1 470
 ZN  1 700 ( 2.2A)
ZN  1 700 (-3.2A)
ZN  1 700 ( 3.3A)
TRP  1 702 ( 2.6A)
 0.92A 1v7zD-1y791:
undetectable		 1v7zD-1y791:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq2 BETA-GALACTOSIDASE

(Arthrobacter
sp. C2-2) 		PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 HIS A 973
ASP A 575
TYR A  98
TRP A 203
 None
 0.83A 1v7zD-1yq2A:
undetectable		 1v7zD-1yq2A:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yqe HYPOTHETICAL UPF0204
PROTEIN AF0625

(Archaeoglobus
fulgidus) 		PF04414
(tRNA_deacylase) 		4 GLU A 135
HIS A  88
HIS A  76
HIS A 138
 None
None
POP  A3000 (-3.8A)
None
 0.95A 1v7zD-1yqeA:
2.6		 1v7zD-1yqeA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3

(Thermoplasma
acidophilum) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 GLU A 288
HIS A 265
HIS A 269
GLU A 266
 ZN  A 800 (-2.8A)
ZN  A 800 (-3.3A)
ZN  A 800 (-3.2A)
ZN  A 800 (-3.4A)
 0.87A 1v7zD-1z1wA:
undetectable		 1v7zD-1z1wA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zzm PUTATIVE
DEOXYRIBONUCLEASE
YJJV

(Escherichia
coli) 		PF01026
(TatD_DNase) 		5 GLU A  97
HIS A 157
ASP A 207
HIS A  11
GLU A 205
 ZN  A 401 ( 2.3A)
ZN  A 402 (-3.3A)
ZN  A 401 (-3.2A)
ZN  A 401 (-3.2A)
None
 1.30A 1v7zD-1zzmA:
undetectable		 1v7zD-1zzmA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b0a HYPOTHETICAL PROTEIN
MJ0783

(Methanocaldococcus
jannaschii) 		PF04199
(Cyclase) 		4 GLU A 148
HIS A  44
ASP A  46
HIS A 136
 None
 0.88A 1v7zD-2b0aA:
undetectable		 1v7zD-2b0aA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f7v AECTYLCITRULLINE
DEACETYLASE

(Xanthomonas
campestris) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 GLU A 155
HIS A  72
ASP A 103
GLU A 131
 CO  A5367 (-2.1A)
CO  A5367 (-3.4A)
CO  A5367 (-2.2A)
CO  A5367 ( 4.0A)
 0.90A 1v7zD-2f7vA:
3.9		 1v7zD-2f7vA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpq BOTULINUM NEUROTOXIN
D LIGHT CHAIN

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		4 GLU A 269
HIS A 229
HIS A 233
GLU A 230
 ZN  A 500 (-1.8A)
ZN  A 500 (-3.1A)
ZN  A 500 (-3.3A)
ZN  A 500 ( 4.2A)
 0.93A 1v7zD-2fpqA:
undetectable		 1v7zD-2fpqA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk1 BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN A
BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN B

(Homo sapiens) 		no annotation 4 GLU M 288
HIS N 350
HIS M 235
GLU N 422
 None
 0.96A 1v7zD-2gk1M:
undetectable		 1v7zD-2gk1M:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h1n OLIGOENDOPEPTIDASE F

(Geobacillus
stearothermophilus) 		PF01432
(Peptidase_M3) 		4 GLU A 384
HIS A 356
HIS A 360
GLU A 357
 ZN  A 601 (-2.2A)
ZN  A 601 (-3.3A)
ZN  A 601 (-3.3A)
ZN  A 601 ( 4.9A)
 0.95A 1v7zD-2h1nA:
undetectable		 1v7zD-2h1nA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mhr MYOHEMERYTHRIN

(Themiste
hennahi) 		PF01814
(Hemerythrin) 		5 GLU A  58
ASP A 111
HIS A  73
TRP A 102
HIS A  54
 FEO  A 119 (-2.5A)
FEO  A 119 ( 2.5A)
FEO  A 119 (-3.5A)
None
FEO  A 119 ( 3.3A)
 1.31A 1v7zD-2mhrA:
undetectable		 1v7zD-2mhrA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mhr MYOHEMERYTHRIN

(Themiste
hennahi) 		PF01814
(Hemerythrin) 		5 GLU A  58
HIS A  25
ASP A 111
TRP A 102
HIS A  54
 FEO  A 119 (-2.5A)
FEO  A 119 ( 3.4A)
FEO  A 119 ( 2.5A)
None
FEO  A 119 ( 3.3A)
 1.14A 1v7zD-2mhrA:
undetectable		 1v7zD-2mhrA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nz9 BOTULINUM NEUROTOXIN
TYPE A

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		4 GLU A 262
HIS A 223
HIS A 227
GLU A 224
 ZN  A   1 (-2.0A)
ZN  A   1 (-3.3A)
ZN  A   1 (-3.3A)
ZN  A   1 ( 4.2A)
 0.93A 1v7zD-2nz9A:
undetectable		 1v7zD-2nz9A:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o36 THIMET
OLIGOPEPTIDASE

(Homo sapiens) 		PF01432
(Peptidase_M3) 		4 GLU A 502
HIS A 473
HIS A 477
GLU A 474
 ZN  A 690 (-2.3A)
ZN  A 690 (-3.4A)
ZN  A 690 (-3.3A)
ZN  A 690 ( 4.1A)
 0.91A 1v7zD-2o36A:
undetectable		 1v7zD-2o36A:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3e NEUROLYSIN

(Rattus
norvegicus) 		PF01432
(Peptidase_M3) 		4 GLU A 503
HIS A 474
HIS A 478
GLU A 475
 ZN  A 679 (-2.1A)
ZN  A 679 (-3.4A)
ZN  A 679 (-3.3A)
ZN  A 679 ( 4.5A)
 0.84A 1v7zD-2o3eA:
undetectable		 1v7zD-2o3eA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pok PEPTIDASE,
M20/M25/M40 FAMILY

(Streptococcus
pneumoniae) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 GLU A 184
HIS A  90
ASP A 123
GLU A 158
 MN  A 460 (-2.3A)
MN  A 460 (-3.7A)
MN  A 460 (-2.6A)
MN  A 460 ( 4.9A)
 0.79A 1v7zD-2pokA:
4.1		 1v7zD-2pokA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2toh TYROSINE
3-MONOOXYGENASE

(Rattus
norvegicus) 		PF00351
(Biopterin_H) 		4 GLU A 376
HIS A 331
HIS A 336
GLU A 332
 FE  A 501 (-2.1A)
FE  A 501 ( 3.3A)
FE  A 501 ( 3.4A)
HBI  A 500 (-3.2A)
 0.99A 1v7zD-2tohA:
undetectable		 1v7zD-2tohA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE

(Bacillus
subtilis) 		PF01979
(Amidohydro_1) 		4 GLU A 136
HIS A  65
ASP A 281
HIS A 223
 FE  A1397 ( 2.6A)
FE  A1397 (-3.3A)
FE  A1397 ( 2.7A)
FE  A1398 (-3.3A)
 0.94A 1v7zD-2vhlA:
undetectable		 1v7zD-2vhlA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vun ENAMIDASE

(Eubacterium
barkeri) 		PF01979
(Amidohydro_1) 		4 GLU A 164
HIS A  69
ASP A 276
HIS A 220
 FE  A 402 ( 2.5A)
ZN  A 401 (-3.3A)
ZN  A 401 (-2.9A)
FE  A 402 (-3.1A)
 0.82A 1v7zD-2vunA:
undetectable		 1v7zD-2vunA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wjf TYROSINE-PROTEIN
PHOSPHATASE CPSB

(Streptococcus
pneumoniae) 		no annotation 5 GLU A  80
HIS A   7
ASP A 199
HIS A 136
HIS A  42
 MN  A1246 (-2.4A)
MN  A1246 ( 3.3A)
MN  A1246 ( 2.8A)
MN  A1245 ( 3.5A)
MN  A1247 ( 3.3A)
 1.14A 1v7zD-2wjfA:
undetectable		 1v7zD-2wjfA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME

(Homo sapiens) 		PF01401
(Peptidase_M2) 		4 GLU A 411
HIS A 383
HIS A 387
GLU A 384
 ZN  A1628 ( 2.4A)
ZN  A1628 ( 3.2A)
ZN  A1628 ( 3.2A)
3ES  A1635 (-2.8A)
 0.85A 1v7zD-2xy9A:
undetectable		 1v7zD-2xy9A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyd ANGIOTENSIN-CONVERTI
NG ENZYME

(Homo sapiens) 		PF01401
(Peptidase_M2) 		4 GLU A 389
HIS A 361
HIS A 365
GLU A 362
 ZN  A1620 ( 2.4A)
3ES  A1611 ( 3.2A)
ZN  A1620 ( 3.2A)
3ES  A1611 (-2.5A)
 0.81A 1v7zD-2xydA:
undetectable		 1v7zD-2xydA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y6i COLLAGENASE

(Hathewaya
histolytica) 		PF01752
(Peptidase_M9)
PF08453
(Peptidase_M9_N) 		4 GLU A 555
HIS A 523
HIS A 527
GLU A 524
 ZN  A1791 (-2.1A)
ZN  A1791 (-3.3A)
ZN  A1791 (-3.3A)
ZN  A1791 ( 4.4A)
 0.97A 1v7zD-2y6iA:
undetectable		 1v7zD-2y6iA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zds PUTATIVE DNA-BINDING
PROTEIN

(Streptomyces
coelicolor) 		PF01261
(AP_endonuc_2)
PF07582
(AP_endonuc_2_N) 		4 GLU A 178
ASP A 235
HIS A  72
GLU A  32
 None
 0.95A 1v7zD-2zdsA:
undetectable		 1v7zD-2zdsA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aal PROBABLE
ENDONUCLEASE 4

(Geobacillus
kaustophilus) 		PF01261
(AP_endonuc_2) 		4 GLU A 259
HIS A 229
ASP A 179
HIS A 214
 FE  A 302 ( 2.4A)
ZN  A 303 ( 3.3A)
FE  A 302 ( 3.2A)
FE  A 302 (-3.4A)
 0.99A 1v7zD-3aalA:
undetectable		 1v7zD-3aalA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aam ENDONUCLEASE IV

(Thermus
thermophilus) 		PF01261
(AP_endonuc_2) 		5 GLU A 248
HIS A  69
HIS A 219
HIS A 204
GLU A 139
 PO4  A 272 (-2.6A)
PO4  A 272 (-4.0A)
MN  A 271 ( 3.4A)
PO4  A 272 ( 4.4A)
PO4  A 272 (-2.9A)
 1.39A 1v7zD-3aamA:
2.7		 1v7zD-3aamA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahm OLIGOPEPTIDASE

(Geobacillus sp.
MO-1) 		no annotation 4 GLU A 384
HIS A 356
HIS A 360
GLU A 357
 ZN  A 565 (-2.1A)
ZN  A 565 (-3.4A)
ZN  A 565 (-3.3A)
ZN  A 565 ( 4.6A)
 0.95A 1v7zD-3ahmA:
undetectable		 1v7zD-3ahmA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bga BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 HIS A 971
ASP A 602
TYR A 119
TRP A 229
 None
 0.91A 1v7zD-3bgaA:
undetectable		 1v7zD-3bgaA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ct9 ACETYLORNITHINE
DEACETYLASE

(Bacteroides
thetaiotaomicron) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 GLU A 161
HIS A  73
ASP A 104
GLU A 137
 None
 0.89A 1v7zD-3ct9A:
4.9		 1v7zD-3ct9A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dec BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 HIS A 947
ASP A 578
TYR A  95
TRP A 205
 None
 0.96A 1v7zD-3decA:
undetectable		 1v7zD-3decA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1

(Homo sapiens) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		4 GLU A 667
HIS A 607
HIS A 611
GLU A 608
 ZN  A 771 ( 2.1A)
ZN  A 771 ( 3.4A)
ZN  A 771 ( 3.3A)
RDF  A 817 (-2.4A)
 0.78A 1v7zD-3dwbA:
undetectable		 1v7zD-3dwbA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e38 TWO-DOMAIN PROTEIN
CONTAINING PREDICTED
PHP-LIKE
METAL-DEPENDENT
PHOSPHOESTERASE

(Bacteroides
vulgatus) 		PF16392
(DUF5001) 		5 GLU A 113
HIS A  46
ASP A 214
HIS A 157
HIS A  76
 ZN  A   2 (-2.7A)
ZN  A   2 ( 3.2A)
ZN  A   2 ( 2.6A)
ZN  A   1 ( 3.4A)
ZN  A   3 ( 3.3A)
 1.20A 1v7zD-3e38A:
undetectable		 1v7zD-3e38A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdg DIPEPTIDASE AC.
METALLO PEPTIDASE.
MEROPS FAMILY M19

(Rhodobacter
sphaeroides) 		PF01244
(Peptidase_M19) 		4 GLU A 137
HIS A 135
HIS A 210
HIS A  11
 MG  A 357 ( 2.4A)
None
MG  A 356 (-3.4A)
MG  A 357 (-3.3A)
 0.99A 1v7zD-3fdgA:
undetectable		 1v7zD-3fdgA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fe4 CARBONIC ANHYDRASE 6

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 HIS A 138
TYR A 263
HIS A 113
GLU A 136
 MG  A 901 (-3.2A)
None
MG  A 901 (-3.4A)
None
 0.83A 1v7zD-3fe4A:
undetectable		 1v7zD-3fe4A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN

(Geobacter
sulfurreducens) 		PF08668
(HDOD) 		5 GLU A 248
HIS A 217
ASP A 237
HIS A 121
HIS A 192
 FE  A 306 ( 2.5A)
FE  A 305 (-3.3A)
FE  A 306 (-2.8A)
FE  A 306 (-3.4A)
FE  A 305 (-3.5A)
 1.26A 1v7zD-3hc1A:
undetectable		 1v7zD-3hc1A:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdi PROCESSING PROTEASE

(Bacillus
halodurans) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 GLU A 126
HIS A  50
HIS A  46
GLU A  49
 CO  A 500 (-2.1A)
CO  A 500 (-3.4A)
CO  A 500 (-3.4A)
CO  A 500 ( 4.3A)
 0.90A 1v7zD-3hdiA:
undetectable		 1v7zD-3hdiA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrt METALLOREGULATOR
SCAR

(Streptococcus
gordonii) 		PF01325
(Fe_dep_repress)
PF02742
(Fe_dep_repr_C)
PF04023
(FeoA) 		4 GLU A  80
HIS A  76
ASP A 160
HIS A 125
 CD  A 501 (-2.7A)
None
CD  A 501 ( 2.9A)
CD  A 501 (-4.0A)
 0.90A 1v7zD-3hrtA:
undetectable		 1v7zD-3hrtA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3io0 ETUB PROTEIN

(Clostridium
kluyveri) 		PF00936
(BMC) 		5 GLU A 262
HIS A 224
HIS A 156
HIS A 195
GLU A 197
 None
 1.38A 1v7zD-3io0A:
undetectable		 1v7zD-3io0A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lub PUTATIVE CREATININE
AMIDOHYDROLASE

(Bacteroides
fragilis) 		PF02633
(Creatininase) 		6 GLU A  31
HIS A  33
ASP A  42
HIS A 119
HIS A 162
GLU A 167
 ZN  A 301 (-2.6A)
ZN  A 302 (-3.3A)
ZN  A 302 ( 2.4A)
ZN  A 301 (-3.4A)
ZN  A 301 ( 4.6A)
ZN  A 302 (-2.1A)
 0.23A 1v7zD-3lubA:
25.9		 1v7zD-3lubA:
28.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3no4 CREATININE
AMIDOHYDROLASE

(Nostoc
punctiforme) 		PF02633
(Creatininase) 		6 GLU A  29
HIS A  31
ASP A  40
HIS A 110
HIS A 167
GLU A 172
 UNL  A 350 ( 4.2A)
NI  A 300 (-3.4A)
NI  A 300 (-2.4A)
UNL  A 350 ( 4.3A)
UNL  A 350 ( 4.4A)
NI  A 300 (-2.3A)
 0.63A 1v7zD-3no4A:
27.0		 1v7zD-3no4A:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nqx SECRETED
METALLOPROTEASE
MCP02

(Pseudoalteromonas
sp. SM9913) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		5 GLU A 369
HIS A 345
HIS A 428
HIS A 349
GLU A 346
 ZN  A   1 (-2.3A)
ZN  A   1 (-3.2A)
None
ZN  A   1 (-3.2A)
ZN  A   1 ( 4.5A)
 1.17A 1v7zD-3nqxA:
undetectable		 1v7zD-3nqxA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ob8 BETA-GALACTOSIDASE

(Kluyveromyces
lactis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N) 		4 HIS A 975
ASP A 610
TYR A  86
TRP A 189
 MN  A3005 (-3.1A)
None
None
None
 0.97A 1v7zD-3ob8A:
undetectable		 1v7zD-3ob8A:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfo PUTATIVE
ACETYLORNITHINE
DEACETYLASE

(Rhodopseudomonas
palustris) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 GLU A 201
HIS A 110
ASP A 143
GLU A 178
 ZN  A 450 (-2.0A)
ZN  A 450 (-3.3A)
ZN  A 450 ( 2.5A)
ZN  A 451 (-2.0A)
 0.89A 1v7zD-3pfoA:
4.4		 1v7zD-3pfoA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qy7 TYROSINE-PROTEIN
PHOSPHATASE YWQE

(Bacillus
subtilis) 		no annotation 5 GLU A  80
HIS A   7
ASP A 194
HIS A 136
HIS A  42
 FE  A 263 (-2.5A)
FE  A 264 ( 3.3A)
FE  A 264 ( 2.6A)
FE  A 263 (-3.4A)
PO4  A 266 ( 3.3A)
 1.16A 1v7zD-3qy7A:
undetectable		 1v7zD-3qy7A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sks PUTATIVE
OLIGOENDOPEPTIDASE F

(Bacillus
anthracis) 		no annotation 4 GLU A 384
HIS A 356
HIS A 360
GLU A 357
 ZN  A 568 ( 2.0A)
ZN  A 568 ( 3.3A)
ZN  A 568 ( 3.3A)
PO4  A 566 (-3.2A)
 0.94A 1v7zD-3sksA:
undetectable		 1v7zD-3sksA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tx8 SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Corynebacterium
glutamicum) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 GLU A 165
HIS A  77
ASP A 103
GLU A 137
 None
 0.77A 1v7zD-3tx8A:
4.4		 1v7zD-3tx8A:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wqo UNCHARACTERIZED
PROTEIN MJ1311

(Methanocaldococcus
jannaschii) 		PF01261
(AP_endonuc_2) 		4 GLU A 260
HIS A 222
ASP A 192
HIS A 231
 MN  A1002 ( 4.9A)
MN  A1001 ( 4.9A)
MN  A1001 ( 4.5A)
MN  A1001 (-3.6A)
 0.93A 1v7zD-3wqoA:
undetectable		 1v7zD-3wqoA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13

(Mycobacterium
tuberculosis) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		4 GLU A 560
HIS A 493
HIS A 497
GLU A 494
 ZN  A1664 ( 2.3A)
ZN  A1664 ( 3.4A)
ZN  A1664 (-3.1A)
RDF  A1665 (-2.5A)
 0.86A 1v7zD-3zukA:
undetectable		 1v7zD-3zukA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23

(Clostridium
botulinum;
Homo sapiens) 		PF01742
(Peptidase_M27)
PF07952
(Toxin_trans) 		4 GLU A 262
HIS A 223
HIS A 227
GLU A 224
 ZN  A1916 (-2.0A)
ZN  A1916 (-3.3A)
ZN  A1916 (-3.3A)
ZN  A1916 ( 4.3A)
 0.90A 1v7zD-3zusA:
undetectable		 1v7zD-3zusA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4are COLLAGENASE G

(Hathewaya
histolytica) 		PF01752
(Peptidase_M9)
PF08453
(Peptidase_M9_N) 		4 GLU A 555
HIS A 523
HIS A 527
GLU A 524
 ZN  A1790 (-2.5A)
ZN  A1790 (-3.3A)
ZN  A1790 (-3.3A)
ZN  A1790 (-3.7A)
 0.98A 1v7zD-4areA:
undetectable		 1v7zD-4areA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b52 BACILLOLYSIN

(Paenibacillus
polymyxa) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		5 GLU A 159
HIS A 135
HIS A 219
HIS A 139
GLU A 136
 ZN  A 401 ( 1.9A)
ZN  A 401 ( 3.2A)
RDF  A 501 (-3.6A)
ZN  A 401 ( 3.3A)
RDF  A 501 (-2.5A)
 1.20A 1v7zD-4b52A:
undetectable		 1v7zD-4b52A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fys AMINOPEPTIDASE N

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 GLU A 411
HIS A 388
HIS A 392
GLU A 389
 None
 0.88A 1v7zD-4fysA:
undetectable		 1v7zD-4fysA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gaa MGC78867 PROTEIN

(Xenopus laevis) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		4 GLU A 315
HIS A 292
HIS A 296
GLU A 293
 ZN  A 701 ( 1.7A)
ZN  A 701 ( 3.2A)
ZN  A 701 ( 3.4A)
BES  A 702 (-2.6A)
 0.93A 1v7zD-4gaaA:
undetectable		 1v7zD-4gaaA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gk8 HISTIDINOL-PHOSPHATA
SE

(Lactococcus
lactis) 		PF02811
(PHP) 		4 GLU A  81
HIS A  11
ASP A 228
HIS A 154
 ZN  A 301 (-2.5A)
ZN  A 303 ( 3.3A)
ZN  A 303 ( 2.6A)
ZN  A 301 ( 3.3A)
 0.96A 1v7zD-4gk8A:
undetectable		 1v7zD-4gk8A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h2k SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Haemophilus
influenzae) 		PF01546
(Peptidase_M20) 		4 GLU A 163
HIS A  67
ASP A 100
GLU A 135
 ZN  A1001 (-2.1A)
ZN  A1001 (-3.3A)
ZN  A1001 ( 2.4A)
ZN  A1002 (-2.0A)
 0.94A 1v7zD-4h2kA:
5.1		 1v7zD-4h2kA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iuw NEUTRAL
ENDOPEPTIDASE

(Lactobacillus
rhamnosus) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		4 GLU A 537
HIS A 477
HIS A 481
GLU A 478
 ZN  A 701 ( 2.2A)
ZN  A 701 ( 3.2A)
ZN  A 701 ( 3.4A)
CIT  A 702 (-2.4A)
 0.81A 1v7zD-4iuwA:
undetectable		 1v7zD-4iuwA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j1l TETANUS TOXIN

(Clostridium
tetani) 		PF01742
(Peptidase_M27) 		4 GLU A 271
HIS A 233
HIS A 237
GLU A 234
 ZN  A 501 (-1.9A)
ZN  A 501 (-3.5A)
ZN  A 501 (-3.3A)
ZN  A 501 ( 4.1A)
 0.84A 1v7zD-4j1lA:
undetectable		 1v7zD-4j1lA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP

(Aspergillus
fumigatus) 		PF02128
(Peptidase_M36) 		5 GLU A 459
HIS A 429
HIS A 520
HIS A 433
GLU A 430
 ZN  A 701 (-2.2A)
ZN  A 701 (-3.2A)
MLA  A 704 (-3.6A)
ZN  A 701 (-3.2A)
MLA  A 704 (-3.7A)
 1.31A 1v7zD-4k90A:
undetectable		 1v7zD-4k90A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ka8 OLIGOPEPTIDASE A

(Arabidopsis
thaliana) 		PF01432
(Peptidase_M3) 		4 GLU A 601
HIS A 571
HIS A 575
GLU A 572
 ZN  A 801 (-2.1A)
ZN  A 801 (-3.3A)
ZN  A 801 (-3.3A)
ZN  A 801 ( 4.6A)
 0.88A 1v7zD-4ka8A:
undetectable		 1v7zD-4ka8A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mmo SSO-CP2
METALLO-CARBOXYPETID
ASE

(Sulfolobus
solfataricus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 GLU A 163
HIS A  71
ASP A 104
GLU A 138
 ZN  A 501 (-1.7A)
ZN  A 501 (-3.2A)
ZN  A 501 (-2.5A)
ZN  A 501 ( 4.5A)
 0.77A 1v7zD-4mmoA:
2.8		 1v7zD-4mmoA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4op4 SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Vibrio cholerae) 		PF01546
(Peptidase_M20) 		4 GLU A 164
HIS A  68
ASP A 101
GLU A 136
 ZN  A 303 ( 2.0A)
ZN  A 303 ( 3.2A)
ZN  A 303 (-2.5A)
ZN  A 302 (-1.7A)
 0.92A 1v7zD-4op4A:
5.1		 1v7zD-4op4A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj6 LEUCYL-CYSTINYL
AMINOPEPTIDASE

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 GLU A 487
HIS A 464
HIS A 468
GLU A 465
 ZN  A1101 ( 1.9A)
ZN  A1101 ( 3.2A)
ZN  A1101 (-3.2A)
LYS  A1102 (-3.4A)
 0.83A 1v7zD-4pj6A:
undetectable		 1v7zD-4pj6A:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ppz SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Neisseria
meningitidis) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 GLU A 164
HIS A  68
ASP A 101
GLU A 136
 ZN  A 601 (-2.1A)
ZN  A 601 (-3.2A)
ZN  A 601 ( 2.3A)
ZN  A 602 ( 1.9A)
 0.91A 1v7zD-4ppzA:
4.8		 1v7zD-4ppzA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q7a N-ACETYL-ORNITHINE/N
-ACETYL-LYSINE
DEACETYLASE

(Sphaerobacter
thermophilus) 		PF01546
(Peptidase_M20) 		4 GLU A 151
HIS A  71
ASP A  95
GLU A 127
 None
 0.82A 1v7zD-4q7aA:
5.4		 1v7zD-4q7aA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xpx BACTERIOHEMERYTHRIN

(Methylococcus
capsulatus) 		PF01814
(Hemerythrin) 		5 GLU A  62
ASP A 122
HIS A  77
TRP A 113
HIS A  58
 FE2  A 201 ( 2.6A)
FE2  A 202 ( 2.6A)
FE2  A 201 (-3.4A)
None
FE2  A 202 (-3.4A)
 1.34A 1v7zD-4xpxA:
undetectable		 1v7zD-4xpxA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xpx BACTERIOHEMERYTHRIN

(Methylococcus
capsulatus) 		PF01814
(Hemerythrin) 		5 GLU A  62
HIS A  22
ASP A 122
TRP A 113
HIS A  58
 FE2  A 201 ( 2.6A)
FE2  A 202 (-3.3A)
FE2  A 202 ( 2.6A)
None
FE2  A 202 (-3.4A)
 1.15A 1v7zD-4xpxA:
undetectable		 1v7zD-4xpxA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zkt BONTOXILYSIN A

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		4 GLU A 251
HIS A 212
HIS A 216
GLU A 213
 ZN  A1301 (-2.3A)
ZN  A1301 (-3.7A)
ZN  A1301 (-3.7A)
ZN  A1301 (-3.3A)
 0.95A 1v7zD-4zktA:
undetectable		 1v7zD-4zktA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr5 NEPRILYSIN

(Oryctolagus
cuniculus) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		4 GLU A 647
HIS A 584
HIS A 588
GLU A 585
 ZN  A 801 ( 2.2A)
ZN  A 801 ( 3.3A)
ZN  A 801 ( 3.2A)
RDF  A 802 (-2.7A)
 0.81A 1v7zD-4zr5A:
undetectable		 1v7zD-4zr5A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2r ANGIOTENSIN-CONVERTI
NG ENZYME

(Drosophila
melanogaster) 		PF01401
(Peptidase_M2) 		4 GLU A 395
HIS A 367
HIS A 371
GLU A 368
 ZN  A1616 (-2.4A)
ZN  A1616 (-3.2A)
ZN  A1616 (-3.3A)
MLT  A1615 (-4.3A)
 0.84A 1v7zD-5a2rA:
undetectable		 1v7zD-5a2rA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3y THERMOLYSIN

(Bacillus
thermoproteolyticus) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		5 GLU A 166
HIS A 142
HIS A 231
HIS A 146
GLU A 143
 ZN  A1317 (-2.3A)
ZN  A1317 (-3.2A)
LYS  A1323 (-3.6A)
ZN  A1317 (-3.2A)
VAL  A1322 (-3.2A)
 1.24A 1v7zD-5a3yA:
undetectable		 1v7zD-5a3yA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dll AMINOPEPTIDASE N

(Francisella
tularensis) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		4 GLU A 329
HIS A 306
HIS A 310
GLU A 307
 ZN  A 901 (-1.6A)
ZN  A 901 (-3.3A)
ZN  A 901 (-3.3A)
ZN  A 901 ( 4.2A)
 0.93A 1v7zD-5dllA:
undetectable		 1v7zD-5dllA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dny DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
MRE11

(Methanocaldococcus
jannaschii) 		PF00149
(Metallophos) 		5 HIS A  10
ASP A  49
HIS A 186
TYR A 202
HIS A 188
 MG  A 401 (-3.5A)
MG  A 402 ( 2.7A)
MG  A 402 (-2.7A)
None
MG  A 401 (-3.4A)
 1.46A 1v7zD-5dnyA:
undetectable		 1v7zD-5dnyA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ds0 PEPTIDASE M42

(Thaumarchaeota
archaeon SCGC
AB-539-E09) 		PF05343
(Peptidase_M42) 		4 GLU A 237
HIS A  66
ASP A 180
GLU A 215
 CO  A 402 (-2.0A)
CO  A 402 (-3.2A)
CO  A 401 ( 2.3A)
CO  A 401 (-2.0A)
 0.88A 1v7zD-5ds0A:
4.6		 1v7zD-5ds0A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fxn THERMOLYSIN

(Bacillus
thermoproteolyticus) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		5 GLU A 166
HIS A 142
HIS A 231
HIS A 146
GLU A 143
 ZN  A1317 (-2.2A)
ZN  A1317 (-3.2A)
LYS  A1319 (-3.5A)
ZN  A1317 (-3.3A)
VAL  A1318 (-3.1A)
 1.21A 1v7zD-5fxnA:
undetectable		 1v7zD-5fxnA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iry DESMOCOLLIN-1

(Homo sapiens) 		PF00028
(Cadherin) 		4 GLU A 402
ASP A 400
TYR A 436
HIS A 439
 CA  A 609 ( 2.1A)
CA  A 609 (-3.0A)
None
None
 0.91A 1v7zD-5iryA:
undetectable		 1v7zD-5iryA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 GLU A 393
HIS A 370
HIS A 374
GLU A 371
 ZN  A1001 ( 1.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
6GA  A1015 (-3.0A)
 0.99A 1v7zD-5j6sA:
2.5		 1v7zD-5j6sA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kd5 METALLOPEPTIDASE

(Bacteroides
thetaiotaomicron) 		PF13402
(Peptidase_M60)
PF17291
(M60-like_N) 		4 GLU A 591
HIS A 574
HIS A 578
GLU A 575
 ZN  A 901 ( 2.3A)
ZN  A 901 ( 3.3A)
ZN  A 901 ( 3.2A)
EDO  A 904 (-2.4A)
 0.85A 1v7zD-5kd5A:
undetectable		 1v7zD-5kd5A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kds F5/8 TYPE C DOMAIN
PROTEIN

(Clostridium
perfringens) 		PF13402
(Peptidase_M60) 		4 GLU A 771
HIS A 756
HIS A 760
GLU A 757
 TLA  A1102 ( 2.5A)
ZN  A1101 (-3.3A)
ZN  A1101 ( 3.3A)
ZN  A1101 ( 4.3A)
 0.81A 1v7zD-5kdsA:
undetectable		 1v7zD-5kdsA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdx METALLOPEPTIDASE

(Pseudomonas
aeruginosa) 		PF13402
(Peptidase_M60) 		4 GLU A 716
HIS A 696
HIS A 700
GLU A 697
 ZN  A1005 (-2.1A)
ZN  A1005 ( 3.3A)
ZN  A1005 (-3.4A)
ZN  A1005 (-4.1A)
 0.96A 1v7zD-5kdxA:
undetectable		 1v7zD-5kdxA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE

(Astrosporangium
hypotensionis) 		PF01432
(Peptidase_M3) 		4 GLU A 492
HIS A 463
HIS A 467
GLU A 464
 ZN  A1001 ( 2.2A)
ZN  A1001 ( 3.3A)
ZN  A1001 ( 3.4A)
K26  A1005 (-2.7A)
 0.89A 1v7zD-5l44A:
undetectable		 1v7zD-5l44A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5syt CAAX PRENYL PROTEASE
1 HOMOLOG

(Homo sapiens) 		PF01435
(Peptidase_M48)
PF16491
(Peptidase_M48_N) 		5 GLU A 415
HIS A 335
HIS A 459
HIS A 339
GLU A 336
 ZN  A 517 (-2.1A)
ZN  A 517 (-3.2A)
DMS  A 523 (-4.3A)
ZN  A 517 (-3.2A)
ZN  A 517 (-3.9A)
 1.26A 1v7zD-5sytA:
undetectable		 1v7zD-5sytA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ux5 BIFUNCTIONAL PROTEIN
PROLINE UTILIZATION
A (PUTA)

(Corynebacterium
freiburgense) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		4 GLU A 404
ASP A 405
HIS A 402
GLU A 157
 None
 0.86A 1v7zD-5ux5A:
undetectable		 1v7zD-5ux5A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xga OSMOLARITY SENSOR
PROTEIN ENVZ

(Escherichia
coli) 		no annotation 4 GLU A  73
HIS A  71
HIS A  77
GLU A  88
 None
 0.90A 1v7zD-5xgaA:
undetectable		 1v7zD-5xgaA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xoy [LYSW]-LYSINE
HYDROLASE

(Thermus
thermophilus) 		PF01546
(Peptidase_M20) 		4 GLU A 148
HIS A  67
ASP A  91
GLU A 125
 None
None
None
LYS  A 401 (-3.7A)
 0.94A 1v7zD-5xoyA:
5.4		 1v7zD-5xoyA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yfb DIPEPTIDYL PEPTIDASE
3

(Armillaria
tabescens) 		no annotation 5 GLU A 501
HIS A 443
HIS A 562
HIS A 448
GLU A 444
 ZN  A 801 (-2.0A)
ZN  A 801 (-3.2A)
None
ZN  A 801 (-3.1A)
GOL  A 804 (-3.9A)
 1.39A 1v7zD-5yfbA:
undetectable		 1v7zD-5yfbA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zb8 PFUENDOQ

(Pyrococcus
furiosus) 		no annotation 4 GLU A  76
HIS A  10
ASP A 193
HIS A 139
 ZN  A 502 ( 2.4A)
ZN  A 502 (-3.3A)
ZN  A 502 (-2.5A)
ZN  A 501 (-3.3A)
 0.91A 1v7zD-5zb8A:
undetectable		 1v7zD-5zb8A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eom MUTT/NUDIX FAMILY
PROTEIN

(Caldithrix
abyssi) 		no annotation 4 GLU A 412
HIS A 379
HIS A 383
GLU A 380
 ZN  A 601 (-1.6A)
ZN  A 601 (-3.2A)
ZN  A 601 (-3.2A)
None
 0.94A 1v7zD-6eomA:
undetectable		 1v7zD-6eomA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6etz BETA-GALACTOSIDASE

(Arthrobacter
sp. 32cB) 		no annotation 4 HIS A 959
ASP A 571
TYR A 108
TRP A 209
 None
 0.90A 1v7zD-6etzA:
undetectable		 1v7zD-6etzA:
17.31