SIMILAR PATTERNS OF AMINO ACIDS FOR 1V55_P_CHDP4271_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a3q PROTEIN (NUCLEAR
FACTOR KAPPA-B P52)

(Homo sapiens) 		PF00554
(RHD_DNA_bind)
PF16179
(RHD_dimer) 		4 LYS A 310
LEU A 309
LEU A 248
PHE A 289
 None
 0.96A 1v55P-1a3qA:
undetectable
1v55W-1a3qA:
0.0		 1v55P-1a3qA:
21.92
1v55W-1a3qA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2i PROTEIN (RESTRICTION
ENDONUCLEASE BGLII)

(Bacillus
subtilis) 		PF09195
(Endonuc-BglII) 		4 LEU A 102
GLN A  95
LEU A 152
PHE A 161
 None
MG  A 601 ( 4.1A)
None
None
 1.02A 1v55P-1d2iA:
undetectable
1v55W-1d2iA:
0.0		 1v55P-1d2iA:
19.62
1v55W-1d2iA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f2r INHIBITOR OF
CASPASE-ACTIVATED
DNASE

(Mus musculus) 		PF02017
(CIDE-N) 		4 LEU I  23
GLN I  31
LEU I  42
PHE I  76
 None
 1.05A 1v55P-1f2rI:
undetectable
1v55W-1f2rI:
0.0		 1v55P-1f2rI:
17.97
1v55W-1f2rI:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f3b GLUTATHIONE
S-TRANSFERASE YA
CHAIN

(Mus musculus) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 LYS A 194
LEU A 197
GLN A 198
LEU A 164
 None
 1.01A 1v55P-1f3bA:
3.5
1v55W-1f3bA:
0.0		 1v55P-1f3bA:
16.67
1v55W-1f3bA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flo FLP RECOMBINASE

(Saccharomyces
cerevisiae) 		PF03930
(Flp_N)
PF05202
(Flp_C) 		4 LYS A 196
LEU A 275
GLN A 273
LEU A 177
 None
 1.05A 1v55P-1floA:
undetectable
1v55W-1floA:
0.0		 1v55P-1floA:
18.74
1v55W-1floA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fq9 FIBROBLAST GROWTH
FACTOR 2

(Homo sapiens) 		PF00167
(FGF) 		4 LEU A  53
GLN A  54
LEU A  32
PHE A 139
 None
 1.03A 1v55P-1fq9A:
undetectable
1v55W-1fq9A:
0.0		 1v55P-1fq9A:
19.75
1v55W-1fq9A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g59 GLUTAMYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00749
(tRNA-synt_1c) 		4 LYS A 149
LEU A 148
LEU A 219
PHE A 223
 None
 0.97A 1v55P-1g59A:
undetectable
1v55W-1g59A:
0.0		 1v55P-1g59A:
18.76
1v55W-1g59A:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gtk PORPHOBILINOGEN
DEAMINASE

(Escherichia
coli) 		PF01379
(Porphobil_deam)
PF03900
(Porphobil_deamC) 		4 LEU A 136
GLN A 133
LEU A 116
PHE A 108
 None
 1.03A 1v55P-1gtkA:
undetectable
1v55W-1gtkA:
0.0		 1v55P-1gtkA:
21.18
1v55W-1gtkA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkk CHITOTRIOSIDASE-1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		4 LEU A  66
GLN A  65
LEU A  94
PHE A 132
 None
 0.97A 1v55P-1hkkA:
0.1
1v55W-1hkkA:
0.0		 1v55P-1hkkA:
21.66
1v55W-1hkkA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jkw CYCLIN H

(Homo sapiens) 		PF00134
(Cyclin_N)
PF16899
(Cyclin_C_2) 		4 ARG A 102
LEU A 106
PHE A 110
LEU A 129
 None
 0.88A 1v55P-1jkwA:
0.7
1v55W-1jkwA:
undetectable		 1v55P-1jkwA:
20.52
1v55W-1jkwA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1juv DIHYDROFOLATE
REDUCTASE

(Escherichia
virus T4) 		PF00186
(DHFR_1) 		4 LEU A  20
GLN A 159
PHE A  22
LEU A 165
 None
None
NDP  A 194 (-3.6A)
None
 0.98A 1v55P-1juvA:
undetectable
1v55W-1juvA:
undetectable		 1v55P-1juvA:
18.99
1v55W-1juvA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfu M-CALPAIN LARGE
SUBUNIT

(Homo sapiens) 		PF00648
(Peptidase_C2)
PF01067
(Calpain_III)
PF13833
(EF-hand_8) 		4 LEU L  45
GLN L  47
PHE L  46
PHE L 131
 None
 1.05A 1v55P-1kfuL:
undetectable
1v55W-1kfuL:
undetectable		 1v55P-1kfuL:
16.26
1v55W-1kfuL:
6.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kkc MANGANESE SUPEROXIDE
DISMUTASE

(Aspergillus
fumigatus) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 LEU A  28
GLN A  29
LEU A  95
PHE A  91
 None
 0.96A 1v55P-1kkcA:
2.2
1v55W-1kkcA:
undetectable		 1v55P-1kkcA:
19.93
1v55W-1kkcA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ko0 DIAMINOPIMELATE
DECARBOXYLASE

(Escherichia
coli) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 ARG A 111
LEU A 115
GLN A 116
LEU A  84
 None
 1.04A 1v55P-1ko0A:
undetectable
1v55W-1ko0A:
undetectable		 1v55P-1ko0A:
16.36
1v55W-1ko0A:
8.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lnl HEMOCYANIN

(Rapana venosa) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 ARG A 217
LEU A 221
GLN A 223
LEU A 287
 None
 0.96A 1v55P-1lnlA:
undetectable
1v55W-1lnlA:
undetectable		 1v55P-1lnlA:
20.98
1v55W-1lnlA:
7.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m33 BIOH PROTEIN

(Escherichia
coli) 		PF00561
(Abhydrolase_1) 		4 LEU A 132
GLN A 131
PHE A 128
LEU A 176
 None
 0.89A 1v55P-1m33A:
undetectable
1v55W-1m33A:
undetectable		 1v55P-1m33A:
20.57
1v55W-1m33A:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oj4 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE

(Escherichia
coli) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 LYS A 271
LEU A  35
PHE A  34
PHE A 245
 None
 0.90A 1v55P-1oj4A:
undetectable
1v55W-1oj4A:
undetectable		 1v55P-1oj4A:
23.79
1v55W-1oj4A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pby QUINOHEMOPROTEIN
AMINE DEHYDROGENASE
60 KDA SUBUNIT

(Paracoccus
denitrificans) 		PF09098
(Dehyd-heme_bind)
PF09099
(Qn_am_d_aIII)
PF09100
(Qn_am_d_aIV)
PF14930
(Qn_am_d_aII) 		4 LYS A 326
LEU A 325
GLN A 293
LEU A 340
 None
 0.86A 1v55P-1pbyA:
undetectable
1v55W-1pbyA:
undetectable		 1v55P-1pbyA:
18.43
1v55W-1pbyA:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgr PROTEIN (G-CSF
RECEPTOR)

(Mus musculus) 		no annotation 4 LEU B 187
GLN B 188
LEU B 176
PHE B 174
 None
 1.03A 1v55P-1pgrB:
undetectable
1v55W-1pgrB:
undetectable		 1v55P-1pgrB:
19.10
1v55W-1pgrB:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rj7 ECTODYSPLASIN A

(Homo sapiens) 		PF00229
(TNF) 		4 LEU A 253
GLN A 254
LEU A 293
PHE A 284
 None
 1.03A 1v55P-1rj7A:
undetectable
1v55W-1rj7A:
undetectable		 1v55P-1rj7A:
19.93
1v55W-1rj7A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rj7 ECTODYSPLASIN A

(Homo sapiens) 		PF00229
(TNF) 		4 LEU A 253
GLN A 254
PHE A 379
PHE A 284
 None
 0.90A 1v55P-1rj7A:
undetectable
1v55W-1rj7A:
undetectable		 1v55P-1rj7A:
19.93
1v55W-1rj7A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1saw HYPOTHETICAL PROTEIN
FLJ36880

(Homo sapiens) 		PF01557
(FAA_hydrolase) 		4 LYS A 151
LEU A 150
LEU A 101
PHE A 217
 None
 0.92A 1v55P-1sawA:
undetectable
1v55W-1sawA:
undetectable		 1v55P-1sawA:
18.53
1v55W-1sawA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sbd SOYBEAN AGGLUTININ

(Glycine max) 		PF00139
(Lectin_legB) 		4 LYS A  31
LEU A  32
GLN A  33
PHE A  74
 None
 1.01A 1v55P-1sbdA:
undetectable
1v55W-1sbdA:
undetectable		 1v55P-1sbdA:
21.99
1v55W-1sbdA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u8v GAMMA-AMINOBUTYRATE
METABOLISM
DEHYDRATASE/ISOMERAS
E

(Clostridium
aminobutyricum) 		PF03241
(HpaB)
PF11794
(HpaB_N) 		4 ARG A 433
LEU A 437
LEU A 391
PHE A 422
 None
 0.85A 1v55P-1u8vA:
3.8
1v55W-1u8vA:
undetectable		 1v55P-1u8vA:
19.70
1v55W-1u8vA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua2 CELL DIVISION
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A 152
LEU A 153
PHE A 156
LEU A 125
 None
 1.02A 1v55P-1ua2A:
2.3
1v55W-1ua2A:
undetectable		 1v55P-1ua2A:
20.17
1v55W-1ua2A:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uus STAT PROTEIN

(Dictyostelium
discoideum) 		PF00017
(SH2)
PF09267
(Dict-STAT-coil) 		4 LYS A 330
LEU A 333
GLN A 334
PHE A 337
 None
 0.95A 1v55P-1uusA:
5.8
1v55W-1uusA:
undetectable		 1v55P-1uusA:
19.58
1v55W-1uusA:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uzg MAJOR ENVELOPE
PROTEIN E

(Dengue virus) 		PF00869
(Flavi_glycoprot)
PF02832
(Flavi_glycop_C) 		4 LYS A  47
LEU A  45
GLN A  46
LEU A 281
 None
 0.82A 1v55P-1uzgA:
undetectable
1v55W-1uzgA:
undetectable		 1v55P-1uzgA:
20.75
1v55W-1uzgA:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v8d HYPOTHETICAL PROTEIN
(TT1679)

(Thermus
thermophilus) 		PF04260
(DUF436) 		4 LEU A  55
GLN A  56
LEU A 100
PHE A  66
 None
 0.99A 1v55P-1v8dA:
undetectable
1v55W-1v8dA:
undetectable		 1v55P-1v8dA:
21.82
1v55W-1v8dA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w61 B-CELL MITOGEN

(Trypanosoma
cruzi) 		PF05544
(Pro_racemase) 		4 LYS A  77
LEU A  80
GLN A  81
LEU A  65
 None
 0.91A 1v55P-1w61A:
undetectable
1v55W-1w61A:
undetectable		 1v55P-1w61A:
20.61
1v55W-1w61A:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wb0 CHITOTRIOSIDASE 1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		4 LEU A  66
GLN A  65
LEU A  94
PHE A 132
 None
 0.90A 1v55P-1wb0A:
undetectable
1v55W-1wb0A:
undetectable		 1v55P-1wb0A:
19.69
1v55W-1wb0A:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y76 PROTEIN ASSOCIATED
TO TIGHT JUNCTIONS

(Rattus
norvegicus) 		PF09045
(L27_2) 		4 LEU A  13
GLN A  14
LEU A  42
PHE A  38
 None
 1.01A 1v55P-1y76A:
undetectable
1v55W-1y76A:
undetectable		 1v55P-1y76A:
13.03
1v55W-1y76A:
33.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli) 		PF04952
(AstE_AspA) 		4 LEU A 184
PHE A 158
LEU A 176
PHE A 172
 None
 0.90A 1v55P-1yw6A:
undetectable
1v55W-1yw6A:
undetectable		 1v55P-1yw6A:
20.54
1v55W-1yw6A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bec CALCINEURIN B
HOMOLOGOUS PROTEIN 2

(Homo sapiens) 		PF13202
(EF-hand_5)
PF13499
(EF-hand_7) 		4 ARG A 112
LEU A 116
PHE A 120
LEU A 181
 None
 1.04A 1v55P-2becA:
undetectable
1v55W-2becA:
undetectable		 1v55P-2becA:
25.67
1v55W-2becA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2brt LEUCOANTHOCYANIDIN
DIOXYGENASE

(Arabidopsis
thaliana) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		4 LEU A 210
GLN A 211
PHE A 304
LEU A 176
 None
None
NAR  A1352 ( 3.5A)
None
 0.94A 1v55P-2brtA:
undetectable
1v55W-2brtA:
undetectable		 1v55P-2brtA:
19.40
1v55W-2brtA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c5q RRAA-LIKE PROTEIN
YER010C

(Saccharomyces
cerevisiae) 		PF03737
(RraA-like) 		4 LYS A 158
LEU A 157
GLN A 156
PHE A  54
 None
None
CME  A 170 ( 4.4A)
None
 1.03A 1v55P-2c5qA:
undetectable
1v55W-2c5qA:
undetectable		 1v55P-2c5qA:
20.79
1v55W-2c5qA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfm THERMOSTABLE DNA
LIGASE

(Pyrococcus
furiosus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 LEU A 522
GLN A 511
PHE A 520
LEU A 428
 None
 1.00A 1v55P-2cfmA:
undetectable
1v55W-2cfmA:
undetectable		 1v55P-2cfmA:
17.30
1v55W-2cfmA:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e8m EPIDERMAL GROWTH
FACTOR RECEPTOR
KINASE SUBSTRATE 8

(Homo sapiens) 		no annotation 4 LYS A  69
LEU A  72
LEU A  64
PHE A  65
 None
 0.90A 1v55P-2e8mA:
undetectable
1v55W-2e8mA:
undetectable		 1v55P-2e8mA:
18.67
1v55W-2e8mA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ehb CALCINEURIN B-LIKE
PROTEIN 4

(Arabidopsis
thaliana) 		PF13202
(EF-hand_5)
PF13499
(EF-hand_7) 		4 LYS A  57
GLN A  61
LEU A  45
PHE A  95
 None
 0.96A 1v55P-2ehbA:
undetectable
1v55W-2ehbA:
undetectable		 1v55P-2ehbA:
21.13
1v55W-2ehbA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fef HYPOTHETICAL PROTEIN
PA2201

(Pseudomonas
aeruginosa) 		PF08929
(DUF1911) 		4 LEU A 173
GLN A 174
PHE A 175
LEU A 153
 None
 1.02A 1v55P-2fefA:
2.3
1v55W-2fefA:
undetectable		 1v55P-2fefA:
23.55
1v55W-2fefA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fgc ACETOLACTATE
SYNTHASE, SMALL
SUBUNIT

(Thermotoga
maritima) 		PF01842
(ACT)
PF10369
(ALS_ss_C) 		4 LEU A 132
GLN A 131
PHE A 130
LEU A 166
 None
 1.04A 1v55P-2fgcA:
undetectable
1v55W-2fgcA:
undetectable		 1v55P-2fgcA:
19.39
1v55W-2fgcA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gnp TRANSCRIPTIONAL
REGULATOR

(Streptococcus
pneumoniae) 		PF04198
(Sugar-bind) 		4 LEU A 258
GLN A 259
LEU A 225
PHE A 230
 None
 1.03A 1v55P-2gnpA:
undetectable
1v55W-2gnpA:
undetectable		 1v55P-2gnpA:
19.19
1v55W-2gnpA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hi3 HOMEODOMAIN-ONLY
PROTEIN

(Mus musculus) 		PF00046
(Homeobox) 		4 ARG A  59
LEU A  55
GLN A  53
PHE A  51
 None
 0.98A 1v55P-2hi3A:
undetectable
1v55W-2hi3A:
undetectable		 1v55P-2hi3A:
13.41
1v55W-2hi3A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2in3 HYPOTHETICAL PROTEIN

(Nitrosomonas
europaea) 		PF01323
(DSBA) 		4 GLN A 117
PHE A 120
LEU A 133
PHE A 151
 None
 0.91A 1v55P-2in3A:
undetectable
1v55W-2in3A:
undetectable		 1v55P-2in3A:
22.22
1v55W-2in3A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2irw CORTICOSTEROID
11-BETA-DEHYDROGENAS
E ISOZYME 1

(Homo sapiens) 		PF00106
(adh_short) 		4 LYS A  68
LEU A  71
GLN A  72
PHE A 102
 None
 0.93A 1v55P-2irwA:
undetectable
1v55W-2irwA:
undetectable		 1v55P-2irwA:
18.75
1v55W-2irwA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix8 ELONGATION FACTOR 3A

(Saccharomyces
cerevisiae) 		PF00005
(ABC_tran) 		4 LYS A1616
LEU A1617
GLN A1449
LEU A1471
 None
 1.00A 1v55P-2ix8A:
undetectable
1v55W-2ix8A:
undetectable		 1v55P-2ix8A:
12.63
1v55W-2ix8A:
5.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nqi CALPAIN-1 CATALYTIC
SUBUNIT

(Rattus
norvegicus) 		PF00648
(Peptidase_C2) 		4 LEU A  55
GLN A  57
PHE A  56
PHE A 141
 None
 1.04A 1v55P-2nqiA:
undetectable
1v55W-2nqiA:
undetectable		 1v55P-2nqiA:
18.98
1v55W-2nqiA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o36 THIMET
OLIGOPEPTIDASE

(Homo sapiens) 		PF01432
(Peptidase_M3) 		4 LEU A 564
GLN A 567
LEU A 601
PHE A 598
 None
 1.01A 1v55P-2o36A:
4.9
1v55W-2o36A:
undetectable		 1v55P-2o36A:
17.45
1v55W-2o36A:
7.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3e NEUROLYSIN

(Rattus
norvegicus) 		PF01432
(Peptidase_M3) 		4 LEU A 257
GLN A 258
LEU A 602
PHE A 599
 None
 0.95A 1v55P-2o3eA:
5.0
1v55W-2o3eA:
undetectable		 1v55P-2o3eA:
17.94
1v55W-2o3eA:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2olt HYPOTHETICAL PROTEIN

(Shewanella
oneidensis) 		PF01865
(PhoU_div) 		4 LEU A 117
GLN A 118
PHE A 121
LEU A 183
 None
 0.86A 1v55P-2oltA:
3.1
1v55W-2oltA:
undetectable		 1v55P-2oltA:
22.38
1v55W-2oltA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2opt ACTII PROTEIN

(Streptomyces
coelicolor) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		4 ARG A  75
LEU A  79
PHE A  83
LEU A  49
 None
 0.68A 1v55P-2optA:
3.1
1v55W-2optA:
undetectable		 1v55P-2optA:
23.19
1v55W-2optA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2otn DIAMINOPIMELATE
EPIMERASE

(Bacillus
anthracis) 		PF01678
(DAP_epimerase) 		4 ARG A  81
LYS A 271
LEU A 258
LEU A  12
 None
 0.72A 1v55P-2otnA:
undetectable
1v55W-2otnA:
undetectable		 1v55P-2otnA:
21.78
1v55W-2otnA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pkg SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
65 KDA REGULATORY
SUBUNIT A ALPHA
ISOFORM

(Homo sapiens) 		PF02985
(HEAT)
PF13646
(HEAT_2) 		4 LYS A 163
LEU A 166
PHE A 170
PHE A 128
 None
 0.88A 1v55P-2pkgA:
undetectable
1v55W-2pkgA:
undetectable		 1v55P-2pkgA:
18.53
1v55W-2pkgA:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q0x UNCHARACTERIZED
PROTEIN

(Trypanosoma
brucei) 		PF08538
(DUF1749) 		4 LEU A 288
GLN A 289
PHE A 290
LEU A  64
 None
 0.90A 1v55P-2q0xA:
undetectable
1v55W-2q0xA:
undetectable		 1v55P-2q0xA:
23.31
1v55W-2q0xA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr6 IMP
DEHYDROGENASE/GMP
REDUCTASE

(Corynebacterium
glutamicum) 		PF00478
(IMPDH) 		4 LEU A 363
GLN A 367
PHE A 366
PHE A  51
 None
 0.94A 1v55P-2qr6A:
undetectable
1v55W-2qr6A:
undetectable		 1v55P-2qr6A:
17.81
1v55W-2qr6A:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4g TELOMERASE REVERSE
TRANSCRIPTASE

(Tetrahymena
thermophila) 		PF12009
(Telomerase_RBD) 		4 GLN A 382
PHE A 379
LEU A 405
PHE A 401
 None
 1.03A 1v55P-2r4gA:
undetectable
1v55W-2r4gA:
undetectable		 1v55P-2r4gA:
19.66
1v55W-2r4gA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uxo HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR

(Pseudomonas
putida) 		PF00440
(TetR_N)
PF08361
(TetR_C_2) 		4 ARG A  90
LYS A  91
LEU A  94
GLN A  95
 None
 0.89A 1v55P-2uxoA:
undetectable
1v55W-2uxoA:
undetectable		 1v55P-2uxoA:
21.16
1v55W-2uxoA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wp0 HOBA
CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA

(Helicobacter
pylori;
Helicobacter
pylori) 		PF12163
(HobA)
no annotation 		4 LEU A  45
GLN C  52
LEU A 170
PHE A 171
 None
 1.05A 1v55P-2wp0A:
undetectable
1v55W-2wp0A:
undetectable		 1v55P-2wp0A:
20.15
1v55W-2wp0A:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2s RPOE, ECF SIGE

(Rhodobacter
sphaeroides) 		PF04542
(Sigma70_r2)
PF04545
(Sigma70_r4) 		4 ARG A  73
LEU A 176
GLN A 178
LEU A 103
 None
 0.99A 1v55P-2z2sA:
undetectable
1v55W-2z2sA:
undetectable		 1v55P-2z2sA:
18.66
1v55W-2z2sA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z63 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 LYS A 349
LEU A 372
PHE A 396
LEU A 356
 None
 1.04A 1v55P-2z63A:
undetectable
1v55W-2z63A:
undetectable		 1v55P-2z63A:
18.51
1v55W-2z63A:
7.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zou SPONDIN-1

(Homo sapiens) 		PF02014
(Reeler) 		5 LEU A 177
GLN A 172
PHE A 171
LEU A  82
PHE A  90
 EDO  A   6 (-3.8A)
EDO  A   6 (-4.9A)
None
None
None
 1.35A 1v55P-2zouA:
undetectable
1v55W-2zouA:
undetectable		 1v55P-2zouA:
15.85
1v55W-2zouA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxx DNA REPLICATION
FACTOR CDT1

(Mus musculus) 		PF08839
(CDT1) 		4 LEU C 199
GLN C 191
LEU C 314
PHE C 310
 None
 0.95A 1v55P-2zxxC:
undetectable
1v55W-2zxxC:
undetectable		 1v55P-2zxxC:
20.21
1v55W-2zxxC:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b86 GENERAL
ODORANT-BINDING
PROTEIN LUSH

(Drosophila
melanogaster) 		PF01395
(PBP_GOBP) 		4 LEU A  44
PHE A  21
LEU A  31
PHE A  36
 None
 1.05A 1v55P-3b86A:
undetectable
1v55W-3b86A:
undetectable		 1v55P-3b86A:
17.60
1v55W-3b86A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ba3 PYRIDOXAMINE
5'-PHOSPHATE
OXIDASE-LIKE PROTEIN

(Lactobacillus
plantarum) 		no annotation 4 LEU A 123
GLN A  87
PHE A 121
LEU A  18
 None
 1.02A 1v55P-3ba3A:
undetectable
1v55W-3ba3A:
undetectable		 1v55P-3ba3A:
21.19
1v55W-3ba3A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bho CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
SUBUNIT 5

(Homo sapiens) 		PF13869
(NUDIX_2) 		5 LYS A 192
LEU A  97
GLN A  98
LEU A 129
PHE A 185
 None
 1.37A 1v55P-3bhoA:
undetectable
1v55W-3bhoA:
undetectable		 1v55P-3bhoA:
19.00
1v55W-3bhoA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cr8 SULFATE
ADENYLYLTRANSFERASE,
ADENYLYLSULFATE
KINASE

(Thiobacillus
denitrificans) 		PF01583
(APS_kinase)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 LEU A  74
GLN A  73
PHE A  79
LEU A  56
 None
 0.94A 1v55P-3cr8A:
undetectable
1v55W-3cr8A:
undetectable		 1v55P-3cr8A:
20.53
1v55W-3cr8A:
6.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1d RNA-INDUCED
TRANSCRIPTIONAL
SILENCING COMPLEX
PROTEIN TAS3

(Schizosaccharomyces
pombe) 		no annotation 4 LEU A 477
GLN A 478
LEU A 443
PHE A 449
 None
 1.04A 1v55P-3d1dA:
undetectable
1v55W-3d1dA:
undetectable		 1v55P-3d1dA:
19.47
1v55W-3d1dA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dqv CULLIN-5

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		4 LEU C1600
GLN C1599
PHE C1598
LEU C1551
 None
 0.91A 1v55P-3dqvC:
undetectable
1v55W-3dqvC:
undetectable		 1v55P-3dqvC:
20.37
1v55W-3dqvC:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e4e CYTOCHROME P450 2E1

(Homo sapiens) 		PF00067
(p450) 		4 LYS A 461
LEU A 460
PHE A 458
LEU A 312
 None
 1.00A 1v55P-3e4eA:
undetectable
1v55W-3e4eA:
undetectable		 1v55P-3e4eA:
19.83
1v55W-3e4eA:
7.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evz METHYLTRANSFERASE

(Pyrococcus
furiosus) 		PF05175
(MTS) 		4 LEU A 202
PHE A 153
LEU A 186
PHE A 182
 None
 1.04A 1v55P-3evzA:
undetectable
1v55W-3evzA:
undetectable		 1v55P-3evzA:
19.78
1v55W-3evzA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3exn PROBABLE
ACETYLTRANSFERASE

(Thermus
thermophilus) 		PF00583
(Acetyltransf_1) 		4 LEU A  63
PHE A  62
LEU A  22
PHE A  26
 None
 0.93A 1v55P-3exnA:
undetectable
1v55W-3exnA:
undetectable		 1v55P-3exnA:
23.02
1v55W-3exnA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eyk HEMAGGLUTININ HA1
CHAIN

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 LEU A 118
GLN A  80
PHE A 120
LEU A 112
 None
 0.97A 1v55P-3eykA:
undetectable
1v55W-3eykA:
undetectable		 1v55P-3eykA:
21.21
1v55W-3eykA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f1v DNA POLYMERASE III
SUBUNIT BETA

(Escherichia
coli) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		4 LYS A 291
LEU A 290
GLN A 289
PHE A 319
 None
 0.98A 1v55P-3f1vA:
undetectable
1v55W-3f1vA:
undetectable		 1v55P-3f1vA:
21.20
1v55W-3f1vA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1z PUTATIVE LYSYL-TRNA
SYNTHETASE

(Salmonella
enterica) 		PF00152
(tRNA-synt_2) 		4 ARG A 188
LEU A 192
GLN A 193
PHE A 196
 None
 0.72A 1v55P-3g1zA:
undetectable
1v55W-3g1zA:
undetectable		 1v55P-3g1zA:
20.94
1v55W-3g1zA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzg MOLYBDATE-BINDING
PERIPLASMIC PROTEIN
PERMEASE

(Xanthomonas
citri) 		PF13531
(SBP_bac_11) 		4 LEU A  80
PHE A 230
LEU A 216
PHE A 212
 None
 0.98A 1v55P-3gzgA:
undetectable
1v55W-3gzgA:
undetectable		 1v55P-3gzgA:
24.09
1v55W-3gzgA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB7

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
PF00575
(S1)
PF03876
(SHS2_Rpb7-N) 		4 LYS G   3
LEU G   5
PHE A1496
LEU G  50
 None
 0.87A 1v55P-3h0gG:
undetectable
1v55W-3h0gG:
undetectable		 1v55P-3h0gG:
22.22
1v55W-3h0gG:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hlm ASPARTATE
AMINOTRANSFERASE,
MITOCHONDRIAL

(Mus musculus) 		PF00155
(Aminotran_1_2) 		4 ARG A 337
LYS A 338
LEU A 341
GLN A 342
 None
 0.89A 1v55P-3hlmA:
undetectable
1v55W-3hlmA:
undetectable		 1v55P-3hlmA:
20.64
1v55W-3hlmA:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrt METALLOREGULATOR
SCAR

(Streptococcus
gordonii) 		PF01325
(Fe_dep_repress)
PF02742
(Fe_dep_repr_C)
PF04023
(FeoA) 		4 ARG A  74
LYS A  75
LEU A  78
PHE A  82
 None
 0.75A 1v55P-3hrtA:
undetectable
1v55W-3hrtA:
undetectable		 1v55P-3hrtA:
18.61
1v55W-3hrtA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb4 VP3

(Parechovirus B) 		PF00073
(Rhv) 		4 LYS C 132
PHE C 129
LEU C 201
PHE C 103
 None
 1.01A 1v55P-3jb4C:
undetectable
1v55W-3jb4C:
undetectable		 1v55P-3jb4C:
19.72
1v55W-3jb4C:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kwp PREDICTED
METHYLTRANSFERASE

(Lactobacillus
brevis) 		PF00590
(TP_methylase) 		4 LYS A 177
LEU A 180
GLN A 181
LEU A 195
 None
 0.96A 1v55P-3kwpA:
undetectable
1v55W-3kwpA:
undetectable		 1v55P-3kwpA:
20.92
1v55W-3kwpA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6c SERINE RACEMASE

(Rattus
norvegicus) 		PF00291
(PALP) 		4 LEU A 171
GLN A 173
LEU A 200
PHE A   9
 None
 1.04A 1v55P-3l6cA:
undetectable
1v55W-3l6cA:
undetectable		 1v55P-3l6cA:
21.73
1v55W-3l6cA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6r SERINE RACEMASE

(Homo sapiens) 		PF00291
(PALP) 		4 LEU A 171
GLN A 173
LEU A 200
PHE A   9
 None
 0.98A 1v55P-3l6rA:
undetectable
1v55W-3l6rA:
undetectable		 1v55P-3l6rA:
21.74
1v55W-3l6rA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mtv PAPAIN-LIKE CYSTEINE
PROTEASE

(Porcine
reproductive
and respiratory
syndrome virus) 		PF05411
(Peptidase_C32) 		4 LYS A 161
LEU A 160
GLN A 148
LEU A  94
 None
 0.93A 1v55P-3mtvA:
undetectable
1v55W-3mtvA:
undetectable		 1v55P-3mtvA:
19.92
1v55W-3mtvA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvu TENA FAMILY
TRANSCRIPTIONAL
REGULATOR

(Ruegeria sp.
TM1040) 		PF03070
(TENA_THI-4) 		4 LEU A 204
PHE A 208
LEU A 187
PHE A 195
 None
None
None
EDO  A 231 (-3.8A)
 0.99A 1v55P-3mvuA:
undetectable
1v55W-3mvuA:
undetectable		 1v55P-3mvuA:
20.30
1v55W-3mvuA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nbu GLUCOSE-6-PHOSPHATE
ISOMERASE

(Escherichia
coli) 		PF00342
(PGI) 		4 LEU A  15
GLN A  16
PHE A  19
LEU A  66
 None
 0.65A 1v55P-3nbuA:
undetectable
1v55W-3nbuA:
undetectable		 1v55P-3nbuA:
18.63
1v55W-3nbuA:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ocj PUTATIVE EXPORTED
PROTEIN

(Bordetella
parapertussis) 		PF13847
(Methyltransf_31) 		4 LEU A 252
GLN A 251
PHE A 254
LEU A  44
 None
None
GOL  A 303 ( 4.4A)
None
 0.99A 1v55P-3ocjA:
undetectable
1v55W-3ocjA:
undetectable		 1v55P-3ocjA:
23.24
1v55W-3ocjA:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3on4 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Legionella
pneumophila) 		PF00440
(TetR_N) 		4 LYS A  82
GLN A  86
PHE A  89
LEU A 135
 None
 0.93A 1v55P-3on4A:
2.4
1v55W-3on4A:
undetectable		 1v55P-3on4A:
19.85
1v55W-3on4A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4

(Saccharomyces
cerevisiae) 		PF11701
(UNC45-central) 		4 LEU A 295
GLN A 294
LEU A 271
PHE A 267
 None
 0.91A 1v55P-3opbA:
undetectable
1v55W-3opbA:
undetectable		 1v55P-3opbA:
14.10
1v55W-3opbA:
5.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3os4 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Yersinia pestis) 		PF04095
(NAPRTase) 		4 LEU A 150
GLN A 149
LEU A 192
PHE A 196
 None
 1.00A 1v55P-3os4A:
undetectable
1v55W-3os4A:
undetectable		 1v55P-3os4A:
20.76
1v55W-3os4A:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pkm CAS6 PROTEIN

(Pyrococcus
furiosus) 		PF01881
(Cas_Cas6) 		4 LYS A 167
LEU A 170
GLN A 171
PHE A 136
 None
 0.96A 1v55P-3pkmA:
undetectable
1v55W-3pkmA:
undetectable		 1v55P-3pkmA:
19.59
1v55W-3pkmA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pl0 UNCHARACTERIZED
PROTEIN

(Methylibium
petroleiphilum) 		PF10014
(2OG-Fe_Oxy_2) 		4 LEU A  15
GLN A  16
LEU A 129
PHE A 130
 None
 0.77A 1v55P-3pl0A:
undetectable
1v55W-3pl0A:
undetectable		 1v55P-3pl0A:
21.36
1v55W-3pl0A:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qc5 PLATELET BINDING
PROTEIN GSPB

(Streptococcus
gordonii) 		no annotation 4 LYS X 466
LEU X 465
GLN X 464
LEU X 434
 None
None
None
NA  X 609 (-4.7A)
 1.05A 1v55P-3qc5X:
undetectable
1v55W-3qc5X:
undetectable		 1v55P-3qc5X:
19.45
1v55W-3qc5X:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qde CELLOBIOSE
PHOSPHORYLASE

(Ruminiclostridium
thermocellum) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 LEU A 134
GLN A 255
LEU A 146
PHE A  72
 None
 1.05A 1v55P-3qdeA:
undetectable
1v55W-3qdeA:
undetectable		 1v55P-3qdeA:
15.31
1v55W-3qdeA:
4.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqz PUTATIVE
UNCHARACTERIZED
PROTEIN YJIK

(Escherichia
coli) 		PF06977
(SdiA-regulated) 		4 LEU A 234
GLN A 235
PHE A 238
LEU A 255
 None
 1.00A 1v55P-3qqzA:
undetectable
1v55W-3qqzA:
undetectable		 1v55P-3qqzA:
22.58
1v55W-3qqzA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rd5 MYPAA.01249.C

(Mycobacterium
avium) 		PF00106
(adh_short) 		4 ARG A 131
LEU A 191
PHE A 246
LEU A 241
 None
 1.01A 1v55P-3rd5A:
undetectable
1v55W-3rd5A:
undetectable		 1v55P-3rd5A:
21.79
1v55W-3rd5A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u58 TETRAHYMENA TEB1 AB

(Tetrahymena
thermophila) 		PF01336
(tRNA_anti-codon) 		4 LYS A 457
LEU A 456
GLN A 455
LEU A 389
 None
 0.88A 1v55P-3u58A:
undetectable
1v55W-3u58A:
undetectable		 1v55P-3u58A:
21.88
1v55W-3u58A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3urz UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF13174
(TPR_6) 		4 LYS A  97
LEU A 100
GLN A 101
LEU A 110
 None
CSX  A 109 ( 4.3A)
None
CSX  A 109 ( 4.4A)
 0.98A 1v55P-3urzA:
4.3
1v55W-3urzA:
undetectable		 1v55P-3urzA:
17.78
1v55W-3urzA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wi3 DNA REPLICATION
REGULATOR SLD3

(Saccharomyces
cerevisiae) 		PF08639
(SLD3) 		4 GLN A 415
PHE A 412
LEU A 398
PHE A 393
 None
 0.97A 1v55P-3wi3A:
2.7
1v55W-3wi3A:
undetectable		 1v55P-3wi3A:
18.93
1v55W-3wi3A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a8e PROBABLE TYROSINE
RECOMBINASE
XERC-LIKE

(Pyrococcus
abyssi) 		PF00589
(Phage_integrase)
PF02899
(Phage_int_SAM_1) 		4 ARG A 184
LEU A 181
LEU A 191
PHE A 192
 None
 0.95A 1v55P-4a8eA:
undetectable
1v55W-4a8eA:
undetectable		 1v55P-4a8eA:
19.68
1v55W-4a8eA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4abn TETRATRICOPEPTIDE
REPEAT PROTEIN 5

(Mus musculus) 		PF16669
(TTC5_OB) 		4 LYS A 281
PHE A 355
LEU A 274
PHE A 405
 None
 0.98A 1v55P-4abnA:
3.3
1v55W-4abnA:
undetectable		 1v55P-4abnA:
19.53
1v55W-4abnA:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aqq L2 PROTEIN III
(PENTON BASE)

(Human
mastadenovirus
B) 		PF01686
(Adeno_Penton_B) 		4 LYS A 124
LEU A 123
GLN A 122
LEU A 414
 None
 0.99A 1v55P-4aqqA:
undetectable
1v55W-4aqqA:
undetectable		 1v55P-4aqqA:
19.73
1v55W-4aqqA:
11.44