SIMILAR PATTERNS OF AMINO ACIDS FOR 1V55_J_CHDJ3060

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flo FLP RECOMBINASE

(Saccharomyces
cerevisiae) 		PF03930
(Flp_N)
PF05202
(Flp_C) 		5 ILE A 350
ARG A 308
MET A 311
THR A 312
LEU A 315
 None
 1.10A 1v55A-1floA:
0.1
1v55J-1floA:
0.0		 1v55A-1floA:
21.78
1v55J-1floA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl6 ATPASE

(Escherichia
coli) 		PF10412
(TrwB_AAD_bind) 		4 ILE A 355
LEU A 358
ARG A 380
LEU A 371
 None
 0.92A 1v55A-1gl6A:
undetectable
1v55J-1gl6A:
undetectable		 1v55A-1gl6A:
21.30
1v55J-1gl6A:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus 1) 		PF00078
(RVT_1) 		4 LEU A 109
MET A 164
THR A 165
LEU A 168
 None
 0.66A 1v55A-1harA:
undetectable
1v55J-1harA:
0.1		 1v55A-1harA:
18.00
1v55J-1harA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hom ANTENNAPEDIA PROTEIN

(Drosophila
melanogaster) 		PF00046
(Homeobox) 		4 LEU A  38
ARG A  29
THR A  27
LEU A  26
 None
 0.94A 1v55A-1homA:
undetectable
1v55J-1homA:
0.0		 1v55A-1homA:
8.24
1v55J-1homA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jed SULFATE
ADENYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		5 ILE A  48
LEU A  49
ARG A  40
THR A  38
LEU A  37
 None
 0.96A 1v55A-1jedA:
0.0
1v55J-1jedA:
undetectable		 1v55A-1jedA:
21.17
1v55J-1jedA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jfi TRANSCRIPTION
REGULATOR NC2 ALPHA
CHAIN
TRANSCRIPTION
REGULATOR NC2 BETA
CHAIN

(Homo sapiens;
Homo sapiens) 		PF00808
(CBFD_NFYB_HMF)
PF00808
(CBFD_NFYB_HMF) 		4 ILE B 122
LEU B 126
THR A  67
LEU A  70
 None
 0.94A 1v55A-1jfiB:
undetectable
1v55J-1jfiB:
1.5		 1v55A-1jfiB:
14.49
1v55J-1jfiB:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01063
(Aminotran_4) 		4 ILE A 332
MET A 293
THR A 292
LEU A 235
 None
 0.78A 1v55A-1kt8A:
undetectable
1v55J-1kt8A:
0.0		 1v55A-1kt8A:
22.71
1v55J-1kt8A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1

(Paracoccus
denitrificans) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		4 ARG A 383
MET A 416
THR A 437
LEU A 436
 None
 0.92A 1v55A-1lrwA:
undetectable
1v55J-1lrwA:
0.0		 1v55A-1lrwA:
21.34
1v55J-1lrwA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qf7 PROTEIN (CATALASE
HPII)

(Escherichia
coli) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 ILE A 666
MET A 736
THR A 734
LEU A 733
 None
 0.92A 1v55A-1qf7A:
0.0
1v55J-1qf7A:
undetectable		 1v55A-1qf7A:
21.37
1v55J-1qf7A:
6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6x ATP:SULFATE
ADENYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		5 ILE A  48
LEU A  49
ARG A  40
THR A  38
LEU A  37
 None
 0.97A 1v55A-1r6xA:
0.0
1v55J-1r6xA:
undetectable		 1v55A-1r6xA:
21.48
1v55J-1r6xA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rt8 FIMBRIN

(Schizosaccharomyces
pombe) 		PF00307
(CH) 		4 ILE A 475
LEU A 486
THR A 392
LEU A 395
 None
 0.93A 1v55A-1rt8A:
0.0
1v55J-1rt8A:
undetectable		 1v55A-1rt8A:
22.05
1v55J-1rt8A:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sr4 CYTOLETHAL
DISTENDING TOXIN
SUBUNIT A

([Haemophilus]
ducreyi) 		PF03498
(CDtoxinA) 		4 LEU A 145
ARG A 114
THR A  79
LEU A  80
 None
 0.94A 1v55A-1sr4A:
undetectable
1v55J-1sr4A:
undetectable		 1v55A-1sr4A:
18.06
1v55J-1sr4A:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vqt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Thermotoga
maritima) 		PF00215
(OMPdecase) 		4 ILE A 143
ARG A 118
MET A 116
LEU A 112
 None
 0.75A 1v55A-1vqtA:
0.0
1v55J-1vqtA:
undetectable		 1v55A-1vqtA:
17.18
1v55J-1vqtA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w1k VANILLYL-ALCOHOL
OXIDASE

(Penicillium
simplicissimum) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		4 ILE A 250
LEU A 253
ARG A 211
LEU A 204
 None
 0.85A 1v55A-1w1kA:
0.0
1v55J-1w1kA:
undetectable		 1v55A-1w1kA:
22.15
1v55J-1w1kA:
6.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ycg NITRIC OXIDE
REDUCTASE

(Moorella
thermoacetica) 		PF00258
(Flavodoxin_1)
PF00753
(Lactamase_B) 		4 ILE A 367
LEU A 340
ARG A 305
LEU A 277
 None
 0.86A 1v55A-1ycgA:
undetectable
1v55J-1ycgA:
undetectable		 1v55A-1ycgA:
22.05
1v55J-1ycgA:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli) 		PF04952
(AstE_AspA) 		4 ILE A  48
LEU A 144
THR A 148
LEU A 211
 None
 0.95A 1v55A-1yw6A:
undetectable
1v55J-1yw6A:
undetectable		 1v55A-1yw6A:
20.62
1v55J-1yw6A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zv4 REGULATOR OF
G-PROTEIN SIGNALING
17

(Homo sapiens) 		PF00615
(RGS) 		4 ILE X 178
LEU X 181
ARG X  95
LEU X 102
 None
 0.93A 1v55A-1zv4X:
undetectable
1v55J-1zv4X:
undetectable		 1v55A-1zv4X:
13.67
1v55J-1zv4X:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zyp ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F

(Salmonella
enterica) 		PF13192
(Thioredoxin_3) 		4 ILE A  67
LEU A  23
THR A  18
LEU A  17
 None
 0.87A 1v55A-1zypA:
undetectable
1v55J-1zypA:
undetectable		 1v55A-1zypA:
16.98
1v55J-1zypA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9b FUSION GLYCOPROTEIN
F0

(Mammalian
rubulavirus 5) 		PF00523
(Fusion_gly) 		4 LEU A 227
TYR A  72
THR A  77
LEU A  80
 None
 0.72A 1v55A-2b9bA:
undetectable
1v55J-2b9bA:
2.3		 1v55A-2b9bA:
21.63
1v55J-2b9bA:
9.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bwg GMP REDUCTASE I

(Homo sapiens) 		PF00478
(IMPDH) 		4 ILE A 154
MET A 113
THR A 114
LEU A 117
 None
 0.89A 1v55A-2bwgA:
undetectable
1v55J-2bwgA:
undetectable		 1v55A-2bwgA:
21.02
1v55J-2bwgA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus) 		PF00496
(SBP_bac_5) 		4 ILE A  36
ARG A  17
THR A 198
LEU A 202
 None
 0.94A 1v55A-2d5wA:
1.6
1v55J-2d5wA:
undetectable		 1v55A-2d5wA:
20.31
1v55J-2d5wA:
7.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e9q 11S GLOBULIN SUBUNIT
BETA

(Cucurbita
maxima) 		PF00190
(Cupin_1) 		4 LEU A 137
ARG A  67
THR A  69
LEU A 155
 None
 0.86A 1v55A-2e9qA:
undetectable
1v55J-2e9qA:
undetectable		 1v55A-2e9qA:
19.40
1v55J-2e9qA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eg5 XANTHOSINE
METHYLTRANSFERASE

(Coffea
canephora) 		PF03492
(Methyltransf_7) 		4 ILE A 287
LEU A 363
THR A 292
LEU A 359
 None
 0.92A 1v55A-2eg5A:
undetectable
1v55J-2eg5A:
undetectable		 1v55A-2eg5A:
22.14
1v55J-2eg5A:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fml MUTT/NUDIX FAMILY
PROTEIN

(Enterococcus
faecalis) 		PF00293
(NUDIX) 		4 ILE A 158
LEU A 151
THR A 181
LEU A 182
 None
 0.94A 1v55A-2fmlA:
undetectable
1v55J-2fmlA:
undetectable		 1v55A-2fmlA:
16.86
1v55J-2fmlA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		4 LEU A 109
MET A 164
THR A 165
LEU A 168
 None
 0.72A 1v55A-2hnzA:
undetectable
1v55J-2hnzA:
undetectable		 1v55A-2hnzA:
19.77
1v55J-2hnzA:
6.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2idc ANTI-SILENCING
PROTEIN 1 AND
HISTONE H3 CHIMERA

(Saccharomyces
cerevisiae) 		PF04729
(ASF1_hist_chap) 		4 ILE A   9
ARG A 108
THR A  43
LEU A  42
 None
 0.84A 1v55A-2idcA:
undetectable
1v55J-2idcA:
undetectable		 1v55A-2idcA:
13.97
1v55J-2idcA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jnu REGULATOR OF
G-PROTEIN SIGNALING
14

(Homo sapiens) 		PF00615
(RGS) 		4 ILE A 109
LEU A 112
THR A  29
LEU A  32
 None
 0.91A 1v55A-2jnuA:
1.3
1v55J-2jnuA:
undetectable		 1v55A-2jnuA:
16.82
1v55J-2jnuA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kbq HARMONIN

(Homo sapiens) 		no annotation 4 ILE A  50
LEU A  58
TYR A  74
LEU A  30
 None
 0.77A 1v55A-2kbqA:
undetectable
1v55J-2kbqA:
undetectable		 1v55A-2kbqA:
8.84
1v55J-2kbqA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2la7 UNCHARACTERIZED
PROTEIN

(Paraburkholderia
xenovorans) 		PF03724
(META) 		4 LEU A 112
ARG A 117
THR A 137
LEU A 138
 None
 0.86A 1v55A-2la7A:
undetectable
1v55J-2la7A:
undetectable		 1v55A-2la7A:
14.14
1v55J-2la7A:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m6k FERRIENTEROBACTIN-BI
NDING PERIPLASMIC
PROTEIN

(Escherichia
coli) 		PF01497
(Peripla_BP_2) 		4 ILE A 142
LEU A 117
THR A  38
LEU A  39
 None
 0.90A 1v55A-2m6kA:
undetectable
1v55J-2m6kA:
undetectable		 1v55A-2m6kA:
18.83
1v55J-2m6kA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ose PROBABLE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Mimivirus) 		PF00160
(Pro_isomerase) 		5 ILE A  33
LEU A  35
TYR A  76
THR A 146
LEU A 131
 None
 1.43A 1v55A-2oseA:
undetectable
1v55J-2oseA:
undetectable		 1v55A-2oseA:
17.28
1v55J-2oseA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0d RHO
GTPASE-ACTIVATING
PROTEIN 9

(Homo sapiens) 		PF00169
(PH) 		4 ILE A 405
LEU A 390
THR A 353
LEU A 352
 None
 0.73A 1v55A-2p0dA:
undetectable
1v55J-2p0dA:
undetectable		 1v55A-2p0dA:
12.67
1v55J-2p0dA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE X 252
MET X 356
THR X 357
LEU X 360
 None
 0.81A 1v55A-2p3gX:
undetectable
1v55J-2p3gX:
undetectable		 1v55A-2p3gX:
19.81
1v55J-2p3gX:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppw CONSERVED DOMAIN
PROTEIN

(Streptococcus
pneumoniae) 		PF02502
(LacAB_rpiB)
PF12408
(DUF3666) 		4 ILE A  58
LEU A  59
THR A  48
LEU A  47
 None
 0.93A 1v55A-2ppwA:
undetectable
1v55J-2ppwA:
undetectable		 1v55A-2ppwA:
16.47
1v55J-2ppwA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjw UNCHARACTERIZED
PROTEIN XCC1541

(Xanthomonas
campestris) 		no annotation 4 ILE A 121
LEU A  99
THR A 106
LEU A 114
 None
 0.93A 1v55A-2qjwA:
undetectable
1v55J-2qjwA:
undetectable		 1v55A-2qjwA:
16.20
1v55J-2qjwA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qv3 VACUOLATING
CYTOTOXIN

(Helicobacter
pylori) 		PF02691
(VacA) 		4 ILE A 590
LEU A 615
THR A 630
LEU A 629
 None
 0.92A 1v55A-2qv3A:
undetectable
1v55J-2qv3A:
undetectable		 1v55A-2qv3A:
22.20
1v55J-2qv3A:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6f EXCINUCLEASE ABC
SUBUNIT A

(Geobacillus
stearothermophilus) 		PF00005
(ABC_tran) 		4 ILE A 689
LEU A 826
THR A 808
LEU A 809
 None
 0.87A 1v55A-2r6fA:
undetectable
1v55J-2r6fA:
undetectable		 1v55A-2r6fA:
19.77
1v55J-2r6fA:
5.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2whk MANNAN
ENDO-1,4-BETA-MANNOS
IDASE

(Bacillus
subtilis) 		PF02156
(Glyco_hydro_26) 		4 ILE A 102
MET A 202
THR A 203
LEU A 208
 None
 0.91A 1v55A-2whkA:
undetectable
1v55J-2whkA:
undetectable		 1v55A-2whkA:
21.47
1v55J-2whkA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wy0 ANGIOTENSINOGEN

(Mus musculus) 		PF00079
(Serpin) 		4 LEU C 309
ARG C 345
THR C 423
LEU C 424
 None
 0.74A 1v55A-2wy0C:
undetectable
1v55J-2wy0C:
undetectable		 1v55A-2wy0C:
21.21
1v55J-2wy0C:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwb COMPLEMENT C3B
ALPHA' CHAIN

(Homo sapiens) 		PF00207
(A2M)
PF01759
(NTR)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		4 ILE B 958
LEU B1276
THR B 924
LEU B 925
 None
 0.92A 1v55A-2xwbB:
2.2
1v55J-2xwbB:
undetectable		 1v55A-2xwbB:
20.77
1v55J-2xwbB:
5.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y24 XYLANASE

(Dickeya
chrysanthemi) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		4 ILE A  75
LEU A  77
THR A  60
LEU A  59
 None
 0.69A 1v55A-2y24A:
undetectable
1v55J-2y24A:
undetectable		 1v55A-2y24A:
22.63
1v55J-2y24A:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y69 CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1

(Bos taurus) 		PF02238
(COX7a) 		5 TYR J  32
ARG J  33
MET J  36
THR J  37
LEU J  40
 None
 0.52A 1v55A-2y69J:
undetectable
1v55J-2y69J:
8.0		 1v55A-2y69J:
10.31
1v55J-2y69J:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yvt HYPOTHETICAL PROTEIN
AQ_1956

(Aquifex
aeolicus) 		PF14582
(Metallophos_3) 		4 ILE A 164
LEU A 165
THR A 144
LEU A 143
 None
 0.93A 1v55A-2yvtA:
undetectable
1v55J-2yvtA:
undetectable		 1v55A-2yvtA:
18.01
1v55J-2yvtA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		4 ILE B 447
LEU B 450
THR B 492
LEU B 491
 None
 0.93A 1v55A-2z7xB:
undetectable
1v55J-2z7xB:
undetectable		 1v55A-2z7xB:
23.01
1v55J-2z7xB:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ziu MUS81 PROTEIN

(Danio rerio) 		PF02732
(ERCC4) 		4 TYR A 471
MET A 475
THR A 476
LEU A 479
 None
 0.75A 1v55A-2ziuA:
undetectable
1v55J-2ziuA:
undetectable		 1v55A-2ziuA:
18.55
1v55J-2ziuA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsg AMINOPEPTIDASE P,
PUTATIVE

(Thermotoga
maritima) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		4 ILE A 230
MET A 177
THR A 176
LEU A 173
 None
 0.89A 1v55A-2zsgA:
undetectable
1v55J-2zsgA:
undetectable		 1v55A-2zsgA:
20.79
1v55J-2zsgA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a24 ALPHA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		4 ILE A  59
ARG A 126
THR A 105
LEU A 106
 None
 0.93A 1v55A-3a24A:
undetectable
1v55J-3a24A:
undetectable		 1v55A-3a24A:
22.34
1v55J-3a24A:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2d CD180 ANTIGEN

(Homo sapiens) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 ILE A 352
LEU A 377
THR A 348
LEU A 372
 None
 0.78A 1v55A-3b2dA:
undetectable
1v55J-3b2dA:
undetectable		 1v55A-3b2dA:
20.65
1v55J-3b2dA:
7.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bn1 PEROSAMINE
SYNTHETASE

(Caulobacter
vibrioides) 		PF01041
(DegT_DnrJ_EryC1) 		4 ILE A 312
TYR A 261
THR A 289
LEU A 346
 None
 0.88A 1v55A-3bn1A:
undetectable
1v55J-3bn1A:
undetectable		 1v55A-3bn1A:
21.12
1v55J-3bn1A:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5y RIBOSE/GALACTOSE
ISOMERASE

(Novosphingobium
aromaticivorans) 		PF02502
(LacAB_rpiB)
PF12408
(DUF3666) 		4 ILE A  58
LEU A  59
THR A  48
LEU A  47
 None
 0.90A 1v55A-3c5yA:
undetectable
1v55J-3c5yA:
undetectable		 1v55A-3c5yA:
17.70
1v55J-3c5yA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c9b VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 75

(Saccharomyces
cerevisiae) 		PF00956
(NAP) 		4 ILE A  80
LEU A  62
ARG A  73
LEU A 200
 None
 0.86A 1v55A-3c9bA:
undetectable
1v55J-3c9bA:
undetectable		 1v55A-3c9bA:
16.41
1v55J-3c9bA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT

(Methanosarcina
barkeri) 		PF03063
(Prismane) 		4 ILE A 129
LEU A 125
THR A 139
LEU A 138
 None
 0.93A 1v55A-3cf4A:
1.4
1v55J-3cf4A:
undetectable		 1v55A-3cf4A:
21.47
1v55J-3cf4A:
7.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3m EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2

(Homo sapiens) 		PF02020
(W2) 		4 ILE A 861
MET A 773
THR A 774
LEU A 777
 None
 0.84A 1v55A-3d3mA:
undetectable
1v55J-3d3mA:
undetectable		 1v55A-3d3mA:
15.54
1v55J-3d3mA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dka DINB-LIKE PROTEIN

(Bacillus
subtilis) 		PF05163
(DinB) 		4 ILE A 105
LEU A 120
THR A  97
LEU A  96
 None
 0.90A 1v55A-3dkaA:
2.7
1v55J-3dkaA:
undetectable		 1v55A-3dkaA:
13.42
1v55J-3dkaA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e4e CYTOCHROME P450 2E1

(Homo sapiens) 		PF00067
(p450) 		4 ILE A 172
LEU A 308
TYR A 485
LEU A 460
 None
 0.89A 1v55A-3e4eA:
0.3
1v55J-3e4eA:
undetectable		 1v55A-3e4eA:
21.62
1v55J-3e4eA:
7.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7f 6-PHOSPHOGLUCONOLACT
ONASE

(Trypanosoma
brucei) 		PF01182
(Glucosamine_iso) 		4 ILE A 230
LEU A 231
THR A 219
LEU A 255
 None
 0.82A 1v55A-3e7fA:
undetectable
1v55J-3e7fA:
undetectable		 1v55A-3e7fA:
19.65
1v55J-3e7fA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehe UDP-GLUCOSE
4-EPIMERASE (GALE-1)

(Archaeoglobus
fulgidus) 		PF01370
(Epimerase) 		4 ILE A 205
ARG A 164
THR A 126
LEU A 271
 None
 0.92A 1v55A-3eheA:
undetectable
1v55J-3eheA:
undetectable		 1v55A-3eheA:
17.73
1v55J-3eheA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE

(Comamonas
testosteroni) 		PF00155
(Aminotran_1_2) 		4 ILE A 475
LEU A 483
ARG A 516
LEU A 423
 None
 0.88A 1v55A-3fddA:
undetectable
1v55J-3fddA:
undetectable		 1v55A-3fddA:
21.01
1v55J-3fddA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 ILE A 462
ARG A 397
THR A 395
LEU A 410
 None
 0.85A 1v55A-3fg4A:
1.9
1v55J-3fg4A:
undetectable		 1v55A-3fg4A:
20.56
1v55J-3fg4A:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fss HISTONE CHAPERONE
RTT106

(Saccharomyces
cerevisiae) 		PF08512
(Rtt106) 		4 ILE A 200
MET A 158
THR A 159
LEU A 160
 None
 0.88A 1v55A-3fssA:
undetectable
1v55J-3fssA:
undetectable		 1v55A-3fssA:
19.04
1v55J-3fssA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gju PUTATIVE
AMINOTRANSFERASE

(Mesorhizobium
japonicum) 		PF00202
(Aminotran_3) 		4 ILE A 131
MET A 159
THR A 160
LEU A 163
 None
 0.88A 1v55A-3gjuA:
undetectable
1v55J-3gjuA:
undetectable		 1v55A-3gjuA:
22.26
1v55J-3gjuA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzy BIPHENYL DIOXYGENASE
SUBUNIT BETA

(Comamonas
testosteroni) 		PF00866
(Ring_hydroxyl_B) 		4 ILE B 165
LEU B  48
ARG B  31
LEU B  36
 None
 0.86A 1v55A-3gzyB:
undetectable
1v55J-3gzyB:
undetectable		 1v55A-3gzyB:
15.34
1v55J-3gzyB:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5t TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Corynebacterium
glutamicum) 		PF00356
(LacI)
PF13377
(Peripla_BP_3) 		4 ILE A 147
LEU A 152
THR A 331
LEU A 332
 None
 0.73A 1v55A-3h5tA:
undetectable
1v55J-3h5tA:
undetectable		 1v55A-3h5tA:
21.02
1v55J-3h5tA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hi8 PROLIFERATING CELL
NUCLEAR ANTIGEN PCNA

(Haloferax
volcanii) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 LEU A  15
ARG A  37
THR A  50
LEU A  51
 None
 0.84A 1v55A-3hi8A:
undetectable
1v55J-3hi8A:
undetectable		 1v55A-3hi8A:
20.53
1v55J-3hi8A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn5 PUTATIVE EXPORTED
PROTEIN BF0290

(Bacteroides
fragilis) 		PF12866
(DUF3823) 		4 ILE A 105
ARG A  36
THR A  34
LEU A  33
 None
 0.78A 1v55A-3hn5A:
undetectable
1v55J-3hn5A:
undetectable		 1v55A-3hn5A:
17.12
1v55J-3hn5A:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4p CAPSID PROTEIN VP1

(Adeno-associated
virus) 		PF00740
(Parvo_coat) 		4 ILE A 374
LEU A 249
ARG A 245
LEU A 317
 None
 0.88A 1v55A-3j4pA:
undetectable
1v55J-3j4pA:
undetectable		 1v55A-3j4pA:
22.36
1v55J-3j4pA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF11

(Schizosaccharomyces
pombe) 		PF13087
(AAA_12)
PF16399
(Aquarius_N) 		4 ILE X 989
MET X 745
THR X 744
LEU X 743
 None
 0.90A 1v55A-3jb9X:
undetectable
1v55J-3jb9X:
undetectable		 1v55A-3jb9X:
16.83
1v55J-3jb9X:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jc7 DNA REPLICATION
COMPLEX GINS PROTEIN
PSF2

(Saccharomyces
cerevisiae) 		PF05916
(Sld5) 		4 ILE B 188
LEU B 192
ARG B 182
LEU B 168
 None
 0.91A 1v55A-3jc7B:
undetectable
1v55J-3jc7B:
undetectable		 1v55A-3jc7B:
16.60
1v55J-3jc7B:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE

(Cupriavidus
pinatubonensis) 		PF00465
(Fe-ADH) 		4 ILE A 343
LEU A 346
ARG A 322
LEU A 248
 None
 0.90A 1v55A-3jzdA:
2.3
1v55J-3jzdA:
undetectable		 1v55A-3jzdA:
22.15
1v55J-3jzdA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k13 5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE

(Bacteroides
thetaiotaomicron) 		PF00809
(Pterin_bind) 		4 ARG A 407
MET A 410
THR A 411
LEU A 414
 None
 0.65A 1v55A-3k13A:
undetectable
1v55J-3k13A:
undetectable		 1v55A-3k13A:
20.20
1v55J-3k13A:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1r HARMONIN

(Homo sapiens) 		PF00595
(PDZ) 		4 ILE A  50
LEU A  58
TYR A  74
LEU A  30
 None
 0.84A 1v55A-3k1rA:
undetectable
1v55J-3k1rA:
undetectable		 1v55A-3k1rA:
14.45
1v55J-3k1rA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl7 PUTATIVE
METAL-DEPENDENT
HYDROLASE

(Parabacteroides
distasonis) 		PF13483
(Lactamase_B_3) 		4 ILE A 101
MET A 128
THR A 157
LEU A 156
 None
None
GOL  A 306 (-4.7A)
None
 0.94A 1v55A-3kl7A:
undetectable
1v55J-3kl7A:
undetectable		 1v55A-3kl7A:
16.47
1v55J-3kl7A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kyj CHEY6 PROTEIN

(Rhodobacter
sphaeroides) 		PF00072
(Response_reg) 		4 ILE B   7
MET B 128
THR B 127
LEU B 124
 None
 0.88A 1v55A-3kyjB:
undetectable
1v55J-3kyjB:
undetectable		 1v55A-3kyjB:
15.09
1v55J-3kyjB:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3muu STRUCTURAL
POLYPROTEIN

(Sindbis virus) 		PF00943
(Alpha_E2_glycop)
PF01589
(Alpha_E1_glycop) 		4 ILE A 283
ARG A 298
THR A 296
LEU A 295
 None
 0.72A 1v55A-3muuA:
undetectable
1v55J-3muuA:
undetectable		 1v55A-3muuA:
21.45
1v55J-3muuA:
6.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nws CELL DIVISION
CONTROL PROTEIN 13

(Saccharomyces
cerevisiae) 		PF16853
(CDC13_N) 		4 ILE A  89
ARG A 116
THR A  42
LEU A  41
 None
 0.92A 1v55A-3nwsA:
undetectable
1v55J-3nwsA:
undetectable		 1v55A-3nwsA:
15.67
1v55J-3nwsA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o6c PYRIDOXINE
5'-PHOSPHATE
SYNTHASE

(Campylobacter
jejuni) 		PF03740
(PdxJ) 		4 ILE A  75
LEU A  78
THR A  39
LEU A  40
 None
 0.93A 1v55A-3o6cA:
undetectable
1v55J-3o6cA:
undetectable		 1v55A-3o6cA:
18.76
1v55J-3o6cA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3om9 LACTATE
DEHYDROGENASE

(Toxoplasma
gondii) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 ILE A 239
TYR A 175
ARG A 174
LEU A 167
 None
None
None
NAD  A 701 (-4.3A)
 0.89A 1v55A-3om9A:
undetectable
1v55J-3om9A:
undetectable		 1v55A-3om9A:
20.12
1v55J-3om9A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8c NCK-ASSOCIATED
PROTEIN 1

(Homo sapiens) 		PF09735
(Nckap1) 		4 LEU B 682
ARG B 705
THR B 709
LEU B 712
 None
 0.87A 1v55A-3p8cB:
1.5
1v55J-3p8cB:
undetectable		 1v55A-3p8cB:
18.35
1v55J-3p8cB:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pf2 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF16569
(GramPos_pilinBB)
PF16570
(GramPos_pilinD3) 		4 ILE A 236
LEU A 240
THR A 270
LEU A 271
 None
 0.74A 1v55A-3pf2A:
undetectable
1v55J-3pf2A:
undetectable		 1v55A-3pf2A:
18.65
1v55J-3pf2A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ra2 CAPSID PROTEIN

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		4 ILE A 375
LEU A 250
ARG A 246
LEU A 318
 None
 0.94A 1v55A-3ra2A:
undetectable
1v55J-3ra2A:
undetectable		 1v55A-3ra2A:
23.22
1v55J-3ra2A:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rr1 PUTATIVE
D-GALACTONATE
DEHYDRATASE

(Ralstonia
pickettii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A  93
LEU A  90
THR A   7
LEU A   6
 None
 0.72A 1v55A-3rr1A:
undetectable
1v55J-3rr1A:
undetectable		 1v55A-3rr1A:
22.10
1v55J-3rr1A:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3se7 VANA

(-) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 TYR A 315
MET A 319
THR A 320
LEU A 324
 None
 0.93A 1v55A-3se7A:
undetectable
1v55J-3se7A:
undetectable		 1v55A-3se7A:
21.97
1v55J-3se7A:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sto SERINE PROTEASE
INHIBITOR

(Schistosoma
haematobium) 		PF00079
(Serpin) 		4 LEU A  47
MET A 392
THR A 391
LEU A 390
 None
 0.95A 1v55A-3stoA:
undetectable
1v55J-3stoA:
undetectable		 1v55A-3stoA:
20.56
1v55J-3stoA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6q CD180 ANTIGEN

(Mus musculus) 		PF13855
(LRR_8) 		4 ILE A 352
LEU A 377
THR A 348
LEU A 372
 None
 0.83A 1v55A-3t6qA:
undetectable
1v55J-3t6qA:
undetectable		 1v55A-3t6qA:
19.07
1v55J-3t6qA:
7.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u15 PROTEIN MDM4

(Homo sapiens) 		PF02201
(SWIB) 		4 ILE A  36
ARG A  87
MET A 101
LEU A 102
 None
 0.86A 1v55A-3u15A:
undetectable
1v55J-3u15A:
undetectable		 1v55A-3u15A:
11.22
1v55J-3u15A:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v85 CYTH-LIKE
PHOSPHATASE

(Arabidopsis
thaliana) 		PF01928
(CYTH) 		4 ILE A 191
LEU A 186
THR A  23
LEU A  22
 None
 0.89A 1v55A-3v85A:
undetectable
1v55J-3v85A:
undetectable		 1v55A-3v85A:
17.05
1v55J-3v85A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vjj P9-1

(Rice black
streaked dwarf
virus) 		PF06043
(Reo_P9) 		4 ILE A  73
LEU A  76
ARG A 341
THR A 178
 None
 0.92A 1v55A-3vjjA:
undetectable
1v55J-3vjjA:
undetectable		 1v55A-3vjjA:
20.11
1v55J-3vjjA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w7b FORMYLTETRAHYDROFOLA
TE DEFORMYLASE

(Thermus
thermophilus) 		PF00551
(Formyl_trans_N)
PF01842
(ACT) 		5 ILE A  93
LEU A 105
ARG A  90
MET A 116
LEU A 270
 None
 1.39A 1v55A-3w7bA:
undetectable
1v55J-3w7bA:
undetectable		 1v55A-3w7bA:
18.86
1v55J-3w7bA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wa8 CRISPR-ASSOCIATED
PROTEIN, CSE2 FAMILY

(Meiothermus
ruber) 		PF09485
(CRISPR_Cse2) 		4 LEU A  68
ARG A 164
THR A 105
LEU A 106
 None
 0.77A 1v55A-3wa8A:
undetectable
1v55J-3wa8A:
undetectable		 1v55A-3wa8A:
13.36
1v55J-3wa8A:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wib HALOALKANE
DEHALOGENASE

(Agrobacterium
fabrum) 		PF00561
(Abhydrolase_1) 		4 ILE A 261
LEU A 264
THR A 250
LEU A 249
 None
 0.78A 1v55A-3wibA:
undetectable
1v55J-3wibA:
undetectable		 1v55A-3wibA:
20.31
1v55J-3wibA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zxs CRYPTOCHROME B

(Rhodobacter
sphaeroides) 		PF04244
(DPRP) 		5 LEU A 455
TYR A 439
ARG A 343
MET A 344
LEU A 347
 None
None
None
SF4  A1510 (-4.5A)
None
 1.33A 1v55A-3zxsA:
undetectable
1v55J-3zxsA:
undetectable		 1v55A-3zxsA:
22.32
1v55J-3zxsA:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2q RETINOIC ACID
INDUCIBLE PROTEIN I

(Anas
platyrhynchos) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF16739
(CARD_2) 		4 ILE A 438
MET A 390
THR A 391
LEU A 394
 None
 0.91A 1v55A-4a2qA:
1.1
1v55J-4a2qA:
undetectable		 1v55A-4a2qA:
18.94
1v55J-4a2qA:
5.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b4o EPIMERASE FAMILY
PROTEIN SDR39U1

(Homo sapiens) 		PF01370
(Epimerase)
PF08338
(DUF1731) 		4 ILE A 193
TYR A 277
THR A 203
LEU A 202
 None
 0.93A 1v55A-4b4oA:
undetectable
1v55J-4b4oA:
undetectable		 1v55A-4b4oA:
22.69
1v55J-4b4oA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8c GLUCOSE-REPRESSIBLE
ALCOHOL
DEHYDROGENASE
TRANSCRIPTIONAL
EFFECTOR

(Saccharomyces
cerevisiae) 		PF03372
(Exo_endo_phos)
PF13855
(LRR_8) 		4 ILE D 376
LEU D 399
THR D 370
LEU D 392
 None
 0.79A 1v55A-4b8cD:
undetectable
1v55J-4b8cD:
undetectable		 1v55A-4b8cD:
21.05
1v55J-4b8cD:
6.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f9l 20.1 ANTI-BTN3A1
ANTIBODY FRAGMENT

(Mus musculus) 		no annotation 4 LEU D 142
ARG D 171
THR D 218
LEU D 217
 None
 0.89A 1v55A-4f9lD:
undetectable
1v55J-4f9lD:
undetectable		 1v55A-4f9lD:
18.81
1v55J-4f9lD:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fho INTERNALIN C2

(Listeria
monocytogenes) 		PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6) 		4 ILE A  78
LEU A  81
THR A 120
LEU A 119
 None
 0.93A 1v55A-4fhoA:
undetectable
1v55J-4fhoA:
undetectable		 1v55A-4fhoA:
18.22
1v55J-4fhoA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmz INTERNALIN

(Listeria
monocytogenes) 		PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13855
(LRR_8) 		4 ILE A 128
LEU A 150
THR A 124
LEU A 145
 None
 0.88A 1v55A-4fmzA:
undetectable
1v55J-4fmzA:
undetectable		 1v55A-4fmzA:
20.75
1v55J-4fmzA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 ILE A 225
LEU A 239
MET A 231
THR A 232
LEU A 234
 None
 1.48A 1v55A-4hq1A:
undetectable
1v55J-4hq1A:
undetectable		 1v55A-4hq1A:
22.32
1v55J-4hq1A:
7.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htf S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE

(Escherichia
coli) 		PF13847
(Methyltransf_31) 		4 ILE B 116
LEU B 135
THR B 111
LEU B 109
 None
 0.87A 1v55A-4htfB:
undetectable
1v55J-4htfB:
undetectable		 1v55A-4htfB:
18.97
1v55J-4htfB:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN

(Lactobacillus
acidophilus) 		PF06100
(MCRA) 		4 ILE A 410
LEU A 438
MET A 458
LEU A 351
 None
 0.88A 1v55A-4ia5A:
undetectable
1v55J-4ia5A:
undetectable		 1v55A-4ia5A:
21.70
1v55J-4ia5A:
8.09